DOK3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1B cell receptor signaling pathway (GO:0050853)6.68814820
2positive regulation of gamma-delta T cell activation (GO:0046645)6.12962939
3positive regulation of B cell differentiation (GO:0045579)5.82976022
4antigen processing and presentation of endogenous antigen (GO:0019883)5.59589241
5regulation of B cell receptor signaling pathway (GO:0050855)5.35955976
6neutrophil activation involved in immune response (GO:0002283)5.34573976
7regulation of B cell differentiation (GO:0045577)5.25786653
8detection of other organism (GO:0098543)5.19256445
9antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.16934865
10antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.16934865
11detection of bacterium (GO:0016045)5.05642345
12negative regulation of phagocytosis (GO:0050765)4.94733765
13respiratory burst (GO:0045730)4.83080311
14cellular response to zinc ion (GO:0071294)4.58336282
15neutrophil activation (GO:0042119)4.57889908
16regulation of gamma-delta T cell differentiation (GO:0045586)4.38233221
17detection of external biotic stimulus (GO:0098581)4.34146271
18leukocyte aggregation (GO:0070486)4.34131792
19positive regulation of mast cell degranulation (GO:0043306)4.26819791
20positive regulation of mast cell activation involved in immune response (GO:0033008)4.26819791
21regulation of gamma-delta T cell activation (GO:0046643)4.19081790
22granulocyte activation (GO:0036230)4.18804884
23positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.15873474
24macrophage activation involved in immune response (GO:0002281)4.14799755
25positive regulation of mast cell activation (GO:0033005)4.14334257
26regulation of interferon-beta biosynthetic process (GO:0045357)4.09682184
27cellular extravasation (GO:0045123)4.07506961
28response to peptidoglycan (GO:0032494)4.06718907
29immunoglobulin mediated immune response (GO:0016064)4.04080402
30detection of molecule of bacterial origin (GO:0032490)4.02657317
31neutrophil mediated immunity (GO:0002446)3.99431339
32negative regulation of lymphocyte mediated immunity (GO:0002707)3.92207497
33response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.92120086
34response to host (GO:0075136)3.92120086
35response to host defenses (GO:0052200)3.92120086
36regulation of mast cell degranulation (GO:0043304)3.91571779
37microglial cell activation (GO:0001774)3.84783410
38positive regulation by symbiont of host defense response (GO:0052509)3.84071641
39modulation by symbiont of host defense response (GO:0052031)3.84071641
40modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.84071641
41modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.84071641
42positive regulation by organism of defense response of other organism involved in symbiotic interact3.84071641
43modulation by symbiont of host immune response (GO:0052553)3.84071641
44detection of biotic stimulus (GO:0009595)3.82228330
45positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.81059294
46defense response to fungus (GO:0050832)3.79162715
47response to fungus (GO:0009620)3.76272864
48negative regulation of erythrocyte differentiation (GO:0045647)3.67957303
49regulation of superoxide anion generation (GO:0032928)3.66761950
50defense response to protozoan (GO:0042832)3.60833885
51macrophage activation (GO:0042116)3.60158946
52regulation of mast cell activation involved in immune response (GO:0033006)3.59724342
53regulation of mast cell activation (GO:0033003)3.58974206
54negative regulation of leukocyte mediated immunity (GO:0002704)3.55887588
55antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.53300743
56response to interleukin-15 (GO:0070672)3.52297301
57negative regulation of cell killing (GO:0031342)3.46158559
58negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.46158559
59Arp2/3 complex-mediated actin nucleation (GO:0034314)3.40285209
60mature B cell differentiation (GO:0002335)3.37985163
61cellular response to type I interferon (GO:0071357)3.36849539
62type I interferon signaling pathway (GO:0060337)3.36849539
63regulation of myeloid leukocyte mediated immunity (GO:0002886)3.35901637
64negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.35720155
65positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.35168548
66response to type I interferon (GO:0034340)3.34933368
67negative regulation of T cell mediated immunity (GO:0002710)3.31880055
68positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.29721006
69regulation of dendritic cell antigen processing and presentation (GO:0002604)3.29659262
70leukotriene biosynthetic process (GO:0019370)3.25340026
71response to protozoan (GO:0001562)3.24432676
72regulation of leukocyte degranulation (GO:0043300)3.23633728
73myeloid cell activation involved in immune response (GO:0002275)3.22037922
74leukocyte degranulation (GO:0043299)3.20775688
75production of molecular mediator involved in inflammatory response (GO:0002532)3.20749776
76adaptation of signaling pathway (GO:0023058)3.17732784
77B cell proliferation (GO:0042100)3.15043995
78cellular response to interleukin-15 (GO:0071350)3.14640373
79negative regulation of B cell proliferation (GO:0030889)3.14397032
80disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.14327033
81killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.14327033
82leukotriene metabolic process (GO:0006691)3.10528270
83lipopolysaccharide-mediated signaling pathway (GO:0031663)3.10205447
84regulation of antigen processing and presentation (GO:0002577)3.09205220
85positive regulation of antigen processing and presentation (GO:0002579)3.08190570
86response to muramyl dipeptide (GO:0032495)3.07159149
87T cell homeostasis (GO:0043029)3.07138200
88regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.05242527
89positive regulation of leukocyte degranulation (GO:0043302)3.04677916
90pentose-phosphate shunt (GO:0006098)3.02798352
91lymphocyte homeostasis (GO:0002260)3.01370153
92antigen receptor-mediated signaling pathway (GO:0050851)3.00184903
93myeloid leukocyte mediated immunity (GO:0002444)2.98316889
94B cell mediated immunity (GO:0019724)2.96691520
95regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.96503879
96negative regulation of interleukin-6 production (GO:0032715)2.96337614
97mannose metabolic process (GO:0006013)2.96220311
98positive regulation of interferon-alpha production (GO:0032727)2.96078779
99regulation of T-helper 2 cell differentiation (GO:0045628)2.95787802
100regulation of regulated secretory pathway (GO:1903305)2.95072348
101negative regulation of innate immune response (GO:0045824)2.93774492
102regulation of B cell apoptotic process (GO:0002902)2.93181255
103B cell homeostasis (GO:0001782)2.92090695
104negative regulation of cytokine production involved in immune response (GO:0002719)2.92071476
105NIK/NF-kappaB signaling (GO:0038061)2.91316457
106regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.91213192
107leukocyte mediated cytotoxicity (GO:0001909)2.90930321
108positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.90528958
109positive regulation of cell adhesion mediated by integrin (GO:0033630)2.90425632
110neutrophil chemotaxis (GO:0030593)2.89589164
111regulation of interleukin-12 biosynthetic process (GO:0045075)2.89543384
112negative regulation of granulocyte differentiation (GO:0030853)2.89511542
113tolerance induction (GO:0002507)2.88252623
114leukocyte cell-cell adhesion (GO:0007159)2.87031505
115germinal center formation (GO:0002467)2.86440002
116myeloid leukocyte activation (GO:0002274)2.85418300
117T cell migration (GO:0072678)2.85176966
118interferon-gamma-mediated signaling pathway (GO:0060333)2.84808444
119T-helper 1 type immune response (GO:0042088)2.83589886
120regulation of B cell proliferation (GO:0030888)2.83524133
121immune response-activating cell surface receptor signaling pathway (GO:0002429)2.82999226
122negative thymic T cell selection (GO:0045060)2.82938185
123negative regulation of T-helper cell differentiation (GO:0045623)2.81978522
124negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.81978522
125regulation of tolerance induction (GO:0002643)2.81871135
126myeloid dendritic cell activation (GO:0001773)2.81699028
127neutrophil migration (GO:1990266)2.81111218
128mature B cell differentiation involved in immune response (GO:0002313)2.80732954
129regulation of interferon-alpha production (GO:0032647)2.79814731
130regulation of phagocytosis (GO:0050764)2.78547645
131positive regulation of B cell activation (GO:0050871)2.77068937
132natural killer cell differentiation (GO:0001779)2.76437426
133leukocyte migration involved in inflammatory response (GO:0002523)2.76029513
134Fc receptor mediated stimulatory signaling pathway (GO:0002431)2.74453775
135negative regulation of interleukin-12 production (GO:0032695)2.73723668
136response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.71247311
137response to host immune response (GO:0052572)2.71247311
138positive thymic T cell selection (GO:0045059)2.71028306
139immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00022.70846920
140Fc-gamma receptor signaling pathway (GO:0038094)2.70846920
141Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)2.70846920
142mast cell activation (GO:0045576)2.69928275
143antigen processing and presentation via MHC class Ib (GO:0002475)2.69526570

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.74759775
2E2F7_22180533_ChIP-Seq_HELA_Human4.61353645
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.13638045
4MYC_22102868_ChIP-Seq_BL_Human3.93061306
5* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.68741762
6* VDR_21846776_ChIP-Seq_THP-1_Human3.66674568
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.40880325
8* SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.37112606
9EGR1_19374776_ChIP-ChIP_THP-1_Human3.10828242
10IRF8_27001747_Chip-Seq_BMDM_Mouse3.02621832
11* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.88221668
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.86328326
13* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.84373245
14SCL_19346495_ChIP-Seq_HPC-7_Human2.76006700
15NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.65363986
16BP1_19119308_ChIP-ChIP_Hs578T_Human2.55731913
17FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.53253861
18FOXM1_23109430_ChIP-Seq_U2OS_Human2.52960893
19* VDR_24763502_ChIP-Seq_THP-1_Human2.51779769
20* SPI1_23547873_ChIP-Seq_NB4_Human2.48744504
21* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.45000609
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.41639648
23* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.41246417
24BRD4_27068464_Chip-Seq_AML-cells_Mouse2.39682476
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.38414807
26MAF_26560356_Chip-Seq_TH1_Human2.34541464
27MYB_26560356_Chip-Seq_TH2_Human2.26425976
28UTX_26944678_Chip-Seq_JUKART_Human2.21743796
29ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.14368135
30TCF7_22412390_ChIP-Seq_EML_Mouse2.13785995
31RUNX1_22412390_ChIP-Seq_EML_Mouse2.12565116
32MYB_26560356_Chip-Seq_TH1_Human2.11157894
33FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.05781276
34RUNX_20019798_ChIP-Seq_JUKART_Human1.97492085
35FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.96912776
36STAT4_19710469_ChIP-ChIP_TH1__Mouse1.91449221
37* SPI1_23127762_ChIP-Seq_K562_Human1.82064539
38NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.81068060
39EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.80210296
40STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.75599920
41MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.74162631
42TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.72036802
43SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.71872310
44IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.67554776
45STAT6_21828071_ChIP-Seq_BEAS2B_Human1.62936404
46VDR_24787735_ChIP-Seq_THP-1_Human1.62807493
47CIITA_25753668_ChIP-Seq_RAJI_Human1.62501398
48* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.60622339
49KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.60198754
50KDM2B_26808549_Chip-Seq_DND41_Human1.55054007
51CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.54124266
52LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.52637328
53GATA1_22025678_ChIP-Seq_K562_Human1.52228804
54MAF_26560356_Chip-Seq_TH2_Human1.51098349
55GATA2_22383799_ChIP-Seq_G1ME_Mouse1.50448872
56* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.50304570
57SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.49666283
58ELK3_25401928_ChIP-Seq_HUVEC_Human1.49054269
59KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.48457581
60TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44883317
61VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.38592179
62CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.38200957
63ELF1_17652178_ChIP-ChIP_JURKAT_Human1.35311645
64PU_27001747_Chip-Seq_BMDM_Mouse1.34659441
65E2F4_17652178_ChIP-ChIP_JURKAT_Human1.33352035
66TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.31689298
67GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.29499888
68ERG_20887958_ChIP-Seq_HPC-7_Mouse1.27758003
69RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.26423985
70GATA3_27048872_Chip-Seq_THYMUS_Human1.25101515
71GATA1_19941826_ChIP-Seq_K562_Human1.23417146
72Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.23077356
73HOXB4_20404135_ChIP-ChIP_EML_Mouse1.21645895
74* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.19479475
75GATA1_19941827_ChIP-Seq_MEL_Mouse1.18293889
76NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.18266692
77SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14761616
78CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14187375
79* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14058106
80VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.12064834
81PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11865099
82FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.11474891
83LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.11468326
84* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11275873
85FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.10878240
86KDM2B_26808549_Chip-Seq_JURKAT_Human1.08998523
87* LXR_22292898_ChIP-Seq_THP-1_Human1.07275147
88ELF1_20517297_ChIP-Seq_JURKAT_Human1.06642029
89GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.06372671
90SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05168293
91STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.01931227
92BCL6_27268052_Chip-Seq_Bcells_Human1.01222029
93CTCF_27219007_Chip-Seq_ERYTHROID_Human0.98832781
94NCOR1_26117541_ChIP-Seq_K562_Human0.96891183
95CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96183480
96PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92972344
97GATA3_26560356_Chip-Seq_TH2_Human0.92887851
98SPI1_20517297_ChIP-Seq_HL60_Human0.91750948
99P68_20966046_ChIP-Seq_HELA_Human0.89642977
100E2F1_21310950_ChIP-Seq_MCF-7_Human0.89302529
101P300_27268052_Chip-Seq_Bcells_Human0.89000073
102SA1_27219007_Chip-Seq_ERYTHROID_Human0.88749328
103GATA2_19941826_ChIP-Seq_K562_Human0.88255350
104CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88248678
105THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.87580346
106* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87334150
107FOXP3_21729870_ChIP-Seq_TREG_Human0.87276400
108BCOR_27268052_Chip-Seq_Bcells_Human0.87081120
109GATA2_21666600_ChIP-Seq_HMVEC_Human0.86816455
110IKZF1_21737484_ChIP-ChIP_HCT116_Human0.86445520
111NOTCH1_21737748_ChIP-Seq_TLL_Human0.85793195
112TFEB_21752829_ChIP-Seq_HELA_Human0.85183271
113VDR_23849224_ChIP-Seq_CD4+_Human0.83860410
114RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82297620
115GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80735732

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.56645928
2MP0003303_peritoneal_inflammation4.25144372
3MP0001800_abnormal_humoral_immune3.76413248
4MP0001790_abnormal_immune_system3.69937391
5MP0005387_immune_system_phenotype3.69937391
6MP0003436_decreased_susceptibility_to3.43531830
7MP0000685_abnormal_immune_system3.29423984
8MP0002452_abnormal_antigen_presenting3.21223827
9MP0005000_abnormal_immune_tolerance3.03740239
10MP0002420_abnormal_adaptive_immunity2.80933423
11MP0009785_altered_susceptibility_to2.78765635
12MP0002419_abnormal_innate_immunity2.78157130
13MP0002723_abnormal_immune_serum2.77586377
14MP0001819_abnormal_immune_cell2.75771581
15MP0005025_abnormal_response_to2.62992160
16MP0002398_abnormal_bone_marrow2.54592717
17MP0005671_abnormal_response_to2.45445073
18MP0002396_abnormal_hematopoietic_system2.40527804
19* MP0000716_abnormal_immune_system2.36250221
20MP0002148_abnormal_hypersensitivity_rea2.33304527
21MP0000689_abnormal_spleen_morphology2.31136700
22MP0009278_abnormal_bone_marrow2.27222969
23MP0005464_abnormal_platelet_physiology2.11777592
24MP0004808_abnormal_hematopoietic_stem2.07603659
25MP0002722_abnormal_immune_system2.04393176
26MP0003300_gastrointestinal_ulcer2.03192942
27* MP0002429_abnormal_blood_cell1.99692553
28MP0002405_respiratory_system_inflammati1.98101681
29MP0003183_abnormal_peptide_metabolism1.94525471
30MP0002166_altered_tumor_susceptibility1.86537724
31MP0000465_gastrointestinal_hemorrhage1.86101322
32MP0001845_abnormal_inflammatory_respons1.84623466
33MP0001853_heart_inflammation1.79881052
34MP0005397_hematopoietic_system_phenotyp1.73819296
35MP0001545_abnormal_hematopoietic_system1.73819296
36MP0001873_stomach_inflammation1.69528001
37MP0004510_myositis1.69360494
38MP0010155_abnormal_intestine_physiology1.69342739
39MP0005058_abnormal_lysosome_morphology1.65935627
40MP0001533_abnormal_skeleton_physiology1.65162910
41MP0004947_skin_inflammation1.57623237
42MP0003763_abnormal_thymus_physiology1.53023541
43MP0009333_abnormal_splenocyte_physiolog1.50248373
44MP0005174_abnormal_tail_pigmentation1.49270637
45MP0003191_abnormal_cellular_cholesterol1.48666359
46MP0003172_abnormal_lysosome_physiology1.47132310
47MP0000703_abnormal_thymus_morphology1.44459412
48MP0005451_abnormal_body_composition1.42507965
49MP0003724_increased_susceptibility_to1.37694918
50MP0002933_joint_inflammation1.37565791
51MP0002006_tumorigenesis1.33143252
52MP0000490_abnormal_crypts_of1.27187968
53MP0008469_abnormal_protein_level1.25898352
54MP0006054_spinal_hemorrhage1.23176979
55MP0006082_CNS_inflammation1.18902961
56MP0009840_abnormal_foam_cell1.17432292
57MP0003866_abnormal_defecation1.16923253
58MP0005310_abnormal_salivary_gland1.14292709
59MP0002138_abnormal_hepatobiliary_system1.09979756
60MP0004883_abnormal_blood_vessel1.09558853
61MP0002277_abnormal_respiratory_mucosa1.09130505
62MP0003806_abnormal_nucleotide_metabolis1.06786472
63* MP0002019_abnormal_tumor_incidence1.06278383
64MP0010307_abnormal_tumor_latency1.03146353
65MP0004381_abnormal_hair_follicle1.01274697
66MP0005076_abnormal_cell_differentiation0.99856660
67MP0003075_altered_response_to0.99226664
68MP0003693_abnormal_embryo_hatching0.98957774
69MP0001851_eye_inflammation0.95988353
70MP0000343_altered_response_to0.93317870
71MP0000015_abnormal_ear_pigmentation0.93042378
72MP0009764_decreased_sensitivity_to0.91750424
73MP0010094_abnormal_chromosome_stability0.91347795
74MP0000858_altered_metastatic_potential0.90905885
75MP0003077_abnormal_cell_cycle0.89764330
76MP0001663_abnormal_digestive_system0.87990743
77MP0003690_abnormal_glial_cell0.87401036
78MP0003448_altered_tumor_morphology0.86333499
79MP0005164_abnormal_response_to0.86254844
80MP0005166_decreased_susceptibility_to0.83984742
81MP0000604_amyloidosis0.83839668
82MP0008004_abnormal_stomach_pH0.83336827
83MP0002095_abnormal_skin_pigmentation0.82780355
84MP0003566_abnormal_cell_adhesion0.82508635
85MP0003656_abnormal_erythrocyte_physiolo0.82054790
86MP0008057_abnormal_DNA_replication0.74587308
87MP0003828_pulmonary_edema0.74565236
88MP0003111_abnormal_nucleus_morphology0.74224757
89MP0010352_gastrointestinal_tract_polyps0.74150195
90MP0000569_abnormal_digit_pigmentation0.73352570
91MP0002136_abnormal_kidney_physiology0.72161390
92MP0000249_abnormal_blood_vessel0.71593417
93MP0009765_abnormal_xenobiotic_induced0.68516822
94MP0001879_abnormal_lymphatic_vessel0.67246999
95MP0003045_fibrosis0.67079895
96MP0009763_increased_sensitivity_to0.66126953
97MP0000313_abnormal_cell_death0.66057503
98MP0003795_abnormal_bone_structure0.65821399
99MP0002132_abnormal_respiratory_system0.65507838
100MP0005075_abnormal_melanosome_morpholog0.63580124
101MP0002998_abnormal_bone_remodeling0.63093314
102MP0005390_skeleton_phenotype0.62644959
103MP0008874_decreased_physiological_sensi0.60204093
104MP0005023_abnormal_wound_healing0.58004494
105MP0005621_abnormal_cell_physiology0.57266910
106MP0008961_abnormal_basal_metabolism0.55998855
107MP0003279_aneurysm0.55962209
108MP0002928_abnormal_bile_duct0.55628440
109MP0001986_abnormal_taste_sensitivity0.55368545
110MP0009931_abnormal_skin_appearance0.55211168
111MP0008873_increased_physiological_sensi0.53350881
112MP0005319_abnormal_enzyme/_coenzyme0.50474547
113MP0000350_abnormal_cell_proliferation0.49723767
114MP0008260_abnormal_autophagy0.49646623
115MP0000609_abnormal_liver_physiology0.48765176
116MP0003091_abnormal_cell_migration0.47611056
117MP0002693_abnormal_pancreas_physiology0.45667627
118MP0005381_digestive/alimentary_phenotyp0.45219249
119MP0003221_abnormal_cardiomyocyte_apopto0.43995311
120MP0005167_abnormal_blood-brain_barrier0.41894045
121MP0009115_abnormal_fat_cell0.38314855

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)6.58218279
2Cellulitis (HP:0100658)6.31104526
3Recurrent abscess formation (HP:0002722)5.76896764
4Recurrent bacterial skin infections (HP:0005406)5.20979144
5Eczematoid dermatitis (HP:0000976)4.99057511
6Verrucae (HP:0200043)4.85768247
7Papilloma (HP:0012740)4.85768247
8Meningitis (HP:0001287)4.85378348
9Orchitis (HP:0100796)4.80567557
10Recurrent viral infections (HP:0004429)4.70708839
11Recurrent bronchitis (HP:0002837)4.63092449
12IgM deficiency (HP:0002850)4.60192912
13Colitis (HP:0002583)4.60024250
14Retrobulbar optic neuritis (HP:0100654)4.44552337
15Optic neuritis (HP:0100653)4.44552337
16Inflammation of the large intestine (HP:0002037)4.32019686
17Gastrointestinal stroma tumor (HP:0100723)4.29306598
18Gastrointestinal inflammation (HP:0004386)4.25181662
19Abnormality of B cell number (HP:0010975)4.18666203
20B lymphocytopenia (HP:0010976)4.18666203
21Recurrent fungal infections (HP:0002841)4.17199975
22Recurrent gram-negative bacterial infections (HP:0005420)4.08723012
23Recurrent sinusitis (HP:0011108)3.98562267
24Osteomyelitis (HP:0002754)3.97350355
25Chronic otitis media (HP:0000389)3.92616425
26Mediastinal lymphadenopathy (HP:0100721)3.89394760
27Panhypogammaglobulinemia (HP:0003139)3.85927759
28Obstructive lung disease (HP:0006536)3.77087690
29Chronic obstructive pulmonary disease (HP:0006510)3.77087690
30Gastrointestinal infarctions (HP:0005244)3.64055656
31Recurrent skin infections (HP:0001581)3.59099457
32Abnormal delayed hypersensitivity skin test (HP:0002963)3.58835142
33Recurrent pneumonia (HP:0006532)3.52278421
34Thyroiditis (HP:0100646)3.48606073
35Sepsis (HP:0100806)3.46975122
36Chronic sinusitis (HP:0011109)3.35372423
37Vasculitis (HP:0002633)3.31932094
38Hypochromic microcytic anemia (HP:0004840)3.31127607
39Lymphopenia (HP:0001888)3.29110650
40Keratoconjunctivitis sicca (HP:0001097)3.26063854
41Abnormality of macrophages (HP:0004311)3.22643610
42Abnormality of cells of the lymphoid lineage (HP:0012140)3.21188219
43Recurrent lower respiratory tract infections (HP:0002783)3.17367967
44Hypochromic anemia (HP:0001931)3.12617552
45Recurrent cutaneous fungal infections (HP:0011370)3.08555834
46Chronic mucocutaneous candidiasis (HP:0002728)3.08555834
47Thrombocytosis (HP:0001894)3.05988194
48Keratoconjunctivitis (HP:0001096)2.98917611
49Emphysema (HP:0002097)2.95137926
50Spontaneous hematomas (HP:0007420)2.92169795
51Restrictive lung disease (HP:0002091)2.89098113
52Small epiphyses (HP:0010585)2.86349688
53Myositis (HP:0100614)2.84080317
54Hemoptysis (HP:0002105)2.82309433
55Elevated erythrocyte sedimentation rate (HP:0003565)2.80979683
56Pustule (HP:0200039)2.76399845
57Episodic fever (HP:0001954)2.70519380
58Interstitial pulmonary disease (HP:0006530)2.63710358
59Gingivitis (HP:0000230)2.62098906
60Prolonged bleeding time (HP:0003010)2.62048210
61Nasal polyposis (HP:0100582)2.56912889
62Petechiae (HP:0000967)2.56247009
63Purpura (HP:0000979)2.56176265
64Abnormality of glycolipid metabolism (HP:0010969)2.55646277
65Abnormality of liposaccharide metabolism (HP:0010968)2.55646277
66Abnormality of glycosphingolipid metabolism (HP:0004343)2.55646277
67Increased cerebral lipofuscin (HP:0011813)2.55061000
68Bronchitis (HP:0012387)2.54997857
69Abnormality of T cell physiology (HP:0011840)2.54789818
70Periodontitis (HP:0000704)2.53963569
71Increased IgM level (HP:0003496)2.53163680
72Pulmonary embolism (HP:0002204)2.49271294
73Anorexia (HP:0002039)2.47884692
74Recurrent otitis media (HP:0000403)2.47573085
75Skin ulcer (HP:0200042)2.47317627
76Vacuolated lymphocytes (HP:0001922)2.44065488
77Amyloidosis (HP:0011034)2.43252669
78Autoimmune thrombocytopenia (HP:0001973)2.42840657
79Eosinophilia (HP:0001880)2.38883756
80Skin rash (HP:0000988)2.38826291
81Abnormality of T cells (HP:0002843)2.38268737
82Urticaria (HP:0001025)2.38264098
83Mitral stenosis (HP:0001718)2.38104573
84Abnormality of the nasal mucosa (HP:0000433)2.37369071
85Hypergammaglobulinemia (HP:0010702)2.33539622
86Abnormality of the pleura (HP:0002103)2.33420114
87Hepatosplenomegaly (HP:0001433)2.31480510
88Microcytic anemia (HP:0001935)2.31210364
89Hypoplasia of the capital femoral epiphysis (HP:0003090)2.27986471
90Chest pain (HP:0100749)2.27226926
91IgA deficiency (HP:0002720)2.25416601
92Hematochezia (HP:0002573)2.25172924
93Abnormality of the fingertips (HP:0001211)2.22952258
94IgG deficiency (HP:0004315)2.22823773
95Increased serum ferritin (HP:0003281)2.21983887
96Leukocytosis (HP:0001974)2.21421013
97Increased IgE level (HP:0003212)2.19790283
98Stomatitis (HP:0010280)2.19529231
99Loss of speech (HP:0002371)2.19496738
100Neutropenia (HP:0001875)2.18594970
101Increased neuronal autofluorescent lipopigment (HP:0002074)2.18299333
102Granulocytopenia (HP:0001913)2.18025625
103Epistaxis (HP:0000421)2.17430390
104Abnormality of the peritoneum (HP:0002585)2.16849260
105Dysostosis multiplex (HP:0000943)2.13733670
106Lymphoma (HP:0002665)2.13623971
107Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.12720961
108Premature loss of primary teeth (HP:0006323)2.10806944
109Gangrene (HP:0100758)2.10076815
110Peritonitis (HP:0002586)2.09989132
111Abnormality of iron homeostasis (HP:0011031)2.08076201
112Viral hepatitis (HP:0006562)2.06362712
113Leukopenia (HP:0001882)2.06053639
114Systemic lupus erythematosus (HP:0002725)2.05670557
115Abnormal platelet volume (HP:0011876)2.05378306
116T lymphocytopenia (HP:0005403)2.03315891
117Pulmonary infiltrates (HP:0002113)2.01654859
118Glomerulopathy (HP:0100820)1.98362349
119Thoracic kyphosis (HP:0002942)1.97467763
120Encephalitis (HP:0002383)1.97324174
121Abnormality of T cell number (HP:0011839)1.96950497
122Impaired platelet aggregation (HP:0003540)1.95783948
123Abnormal platelet function (HP:0011869)1.95783948
124Combined immunodeficiency (HP:0005387)1.95442424
125Abnormality of the heme biosynthetic pathway (HP:0010472)1.94863251
126Hypertensive crisis (HP:0100735)1.94416894
127Papilledema (HP:0001085)1.92828672
128Severe combined immunodeficiency (HP:0004430)1.90878261
129Hypoplasia of the thymus (HP:0000778)1.89753404
130Gingival bleeding (HP:0000225)1.88007899
131Abnormality of eosinophils (HP:0001879)1.87368380
132Abnormality of the thoracic spine (HP:0100711)1.85966720
133Flattened epiphyses (HP:0003071)1.83102949
134Fatigue (HP:0012378)1.81694000
135Ulnar bowing (HP:0003031)1.78972023
136Arterial thrombosis (HP:0004420)1.77765025

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.18843140
2MAP3K104.75409080
3ERN14.04936504
4BLK3.67215278
5GRK63.20677791
6RIPK43.15417818
7BTK2.62039825
8PRPF4B2.57528358
9CSF1R2.38263126
10IRAK42.28678217
11SYK2.28064658
12STK102.11700893
13EEF2K2.07136672
14FES2.04504742
15TYK21.89432894
16LRRK21.82910262
17SIK21.77194612
18TBK11.68572038
19TRIB31.66979018
20PKN21.57854350
21KIT1.56993937
22TEC1.53556343
23MAP3K31.51143428
24LYN1.49860976
25HCK1.49266321
26CSK1.46706429
27MAP3K141.46519958
28MAP3K131.41582400
29CLK11.40819281
30ZAP701.39643345
31TXK1.29630092
32MAP2K31.28570120
33TGFBR21.26024877
34MAP3K11.24030736
35IRAK31.23415349
36PIM11.17260139
37JAK11.14302750
38TAOK21.13145299
39NEK21.11789644
40SMG11.08587259
41EIF2AK31.07370553
42KSR21.06295936
43EPHB11.02844535
44IKBKB1.01803068
45LCK1.01158933
46CDK120.99075261
47CDK40.96357204
48IKBKE0.96221977
49JAK30.96065131
50MATK0.95547253
51MARK30.94760181
52ITK0.91513948
53TAOK30.91282008
54MAPK40.89921183
55YES10.88908999
56MARK20.88668341
57STK40.88600673
58TNK20.87228257
59CDK190.83057537
60BMPR20.81086755
61RPS6KA40.80817458
62IRAK10.77519320
63PDPK10.75451744
64IRAK20.75369671
65FGR0.72982252
66TESK20.70566454
67CDC42BPA0.68902435
68SCYL20.65784772
69SIK30.62920334
70PTK60.61734659
71MAP3K60.60486161
72MAPK70.59554256
73CAMK1D0.56130611
74MAP3K50.55885099
75HIPK20.54899714
76MAP3K110.52071069
77PIK3CG0.51470791
78ABL10.50822156
79CDK90.50644949
80JAK20.50582906
81TLK10.50206341
82MAP3K80.49743001
83ALK0.48553366
84PTK2B0.47734393
85RPS6KA60.47623046
86TRPM70.47243184
87DAPK20.46305224
88MAPK120.45996723
89MAP2K40.45623330
90MAPK110.45127329
91DYRK1B0.44588483
92KDR0.43439690
93PDK10.42705986
94RPS6KB20.42568849
95STK110.41654736
96RPS6KL10.41145606
97RPS6KC10.41145606
98FYN0.41114060
99CHUK0.39796452
100TTN0.39425551
101MAPKAPK20.39230026
102PRKCQ0.38619794
103MAP2K60.38539187
104CAMK1G0.38057250
105MAP3K70.37760837
106PRKCD0.37411105
107RET0.36796548
108PRKG20.36792481
109CDK60.36677938
110PIM20.35055589
111SIK10.34207161
112BRD40.34044842
113PRKCH0.33686129
114DYRK30.33607334
115FLT30.33164017
116FGFR40.32972491
117PRKD20.32172708
118GRK70.32060710
119EGFR0.31570161
120MAPKAPK30.31174061
121FGFR30.30916175
122SGK30.30164840
123PAK40.29791625
124BMX0.28223697
125PRKD10.27564342
126BCKDK0.26385039
127GRK10.26360319
128TAOK10.25939929
129MST40.24034767
130RAF10.23995141

Predicted pathways (KEGG)

RankGene SetZ-score
1B cell receptor signaling pathway_Homo sapiens_hsa046624.58819969
2Primary immunodeficiency_Homo sapiens_hsa053404.09614836
3Leishmaniasis_Homo sapiens_hsa051402.92012850
4Graft-versus-host disease_Homo sapiens_hsa053322.69200758
5Autoimmune thyroid disease_Homo sapiens_hsa053202.55904386
6Osteoclast differentiation_Homo sapiens_hsa043802.54838245
7Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.45980149
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.42785643
9Hematopoietic cell lineage_Homo sapiens_hsa046402.29042718
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.18917555
11Type I diabetes mellitus_Homo sapiens_hsa049402.08010470
12Staphylococcus aureus infection_Homo sapiens_hsa051502.02542130
13Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.98784473
14Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.98694116
15Other glycan degradation_Homo sapiens_hsa005111.90898049
16Tuberculosis_Homo sapiens_hsa051521.83717981
17Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.79791269
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.74660778
19Antigen processing and presentation_Homo sapiens_hsa046121.63325468
20Base excision repair_Homo sapiens_hsa034101.61834448
21DNA replication_Homo sapiens_hsa030301.59260612
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.58285925
23Measles_Homo sapiens_hsa051621.54015953
24Chemokine signaling pathway_Homo sapiens_hsa040621.53568609
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.52078201
26Leukocyte transendothelial migration_Homo sapiens_hsa046701.51108173
27Pertussis_Homo sapiens_hsa051331.49956116
28Herpes simplex infection_Homo sapiens_hsa051681.48502207
29Non-homologous end-joining_Homo sapiens_hsa034501.47752382
30RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.47106684
31Shigellosis_Homo sapiens_hsa051311.43735765
32Legionellosis_Homo sapiens_hsa051341.35739978
33Toxoplasmosis_Homo sapiens_hsa051451.29108654
34Rheumatoid arthritis_Homo sapiens_hsa053231.28179374
35Platelet activation_Homo sapiens_hsa046111.25983428
36Acute myeloid leukemia_Homo sapiens_hsa052211.24934279
37Chronic myeloid leukemia_Homo sapiens_hsa052201.24424996
38Hepatitis B_Homo sapiens_hsa051611.24225409
39Apoptosis_Homo sapiens_hsa042101.22995456
40Influenza A_Homo sapiens_hsa051641.21761126
41Malaria_Homo sapiens_hsa051441.21153727
42Transcriptional misregulation in cancer_Homo sapiens_hsa052021.18864208
43Non-small cell lung cancer_Homo sapiens_hsa052231.18285653
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.17747373
45Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.15777160
46Jak-STAT signaling pathway_Homo sapiens_hsa046301.14341780
47Epstein-Barr virus infection_Homo sapiens_hsa051691.10415941
48Lysosome_Homo sapiens_hsa041421.09871235
49Salmonella infection_Homo sapiens_hsa051321.06080663
50Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.05072676
51Mismatch repair_Homo sapiens_hsa034301.05036329
52Asthma_Homo sapiens_hsa053101.04782291
53Neurotrophin signaling pathway_Homo sapiens_hsa047221.04636707
54T cell receptor signaling pathway_Homo sapiens_hsa046601.04441269
55Pancreatic cancer_Homo sapiens_hsa052121.03388254
56Ribosome_Homo sapiens_hsa030101.01968823
57Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.99358480
58TNF signaling pathway_Homo sapiens_hsa046680.99136254
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.94123860
60Pentose phosphate pathway_Homo sapiens_hsa000300.88285082
61Viral carcinogenesis_Homo sapiens_hsa052030.86830656
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.79945396
63AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.77382184
64VEGF signaling pathway_Homo sapiens_hsa043700.77199018
65Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.76189647
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.76023935
67Systemic lupus erythematosus_Homo sapiens_hsa053220.74818940
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74583497
69Homologous recombination_Homo sapiens_hsa034400.69535921
70Viral myocarditis_Homo sapiens_hsa054160.67670387
71HTLV-I infection_Homo sapiens_hsa051660.66896074
72Renal cell carcinoma_Homo sapiens_hsa052110.66289086
73Phagosome_Homo sapiens_hsa041450.66069979
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.65970610
75N-Glycan biosynthesis_Homo sapiens_hsa005100.64264035
76Hepatitis C_Homo sapiens_hsa051600.64159682
77Small cell lung cancer_Homo sapiens_hsa052220.64157534
78Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.61378646
79African trypanosomiasis_Homo sapiens_hsa051430.59440921
80Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.55992914
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.55482379
82Renin-angiotensin system_Homo sapiens_hsa046140.55180855
83Spliceosome_Homo sapiens_hsa030400.53191483
84Insulin resistance_Homo sapiens_hsa049310.52106872
85Amoebiasis_Homo sapiens_hsa051460.51561108
86p53 signaling pathway_Homo sapiens_hsa041150.49613581
87Caffeine metabolism_Homo sapiens_hsa002320.48559350
88Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46559351
89FoxO signaling pathway_Homo sapiens_hsa040680.45659611
90Choline metabolism in cancer_Homo sapiens_hsa052310.45089379
91GnRH signaling pathway_Homo sapiens_hsa049120.45037047
92Cell cycle_Homo sapiens_hsa041100.44720625
93Colorectal cancer_Homo sapiens_hsa052100.44062751
94HIF-1 signaling pathway_Homo sapiens_hsa040660.43882625
95Endocytosis_Homo sapiens_hsa041440.42858164
96Endometrial cancer_Homo sapiens_hsa052130.41709640
97Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41392311
98Glioma_Homo sapiens_hsa052140.40947690
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40316715
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39294412
101Sphingolipid signaling pathway_Homo sapiens_hsa040710.38633086
102Glycerophospholipid metabolism_Homo sapiens_hsa005640.37856909
103Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.37255071
104Type II diabetes mellitus_Homo sapiens_hsa049300.35942767
105Allograft rejection_Homo sapiens_hsa053300.35685052
106Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.33773955
107Bladder cancer_Homo sapiens_hsa052190.33339848
108Notch signaling pathway_Homo sapiens_hsa043300.32859739
109MicroRNAs in cancer_Homo sapiens_hsa052060.32760356
110Phospholipase D signaling pathway_Homo sapiens_hsa040720.32744670
111MAPK signaling pathway_Homo sapiens_hsa040100.31892755
112Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.31475990
113Inositol phosphate metabolism_Homo sapiens_hsa005620.31318703
114mTOR signaling pathway_Homo sapiens_hsa041500.31182990
115Dorso-ventral axis formation_Homo sapiens_hsa043200.31081447
116Sulfur relay system_Homo sapiens_hsa041220.29825302
117Prolactin signaling pathway_Homo sapiens_hsa049170.29049885
118Regulation of actin cytoskeleton_Homo sapiens_hsa048100.28696306
119Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.28425909
120Lysine degradation_Homo sapiens_hsa003100.27575063
121Rap1 signaling pathway_Homo sapiens_hsa040150.26919158
122ErbB signaling pathway_Homo sapiens_hsa040120.24902178

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