DOK4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cardiac chamber formation (GO:0003207)7.00184113
2cardiac ventricle formation (GO:0003211)6.18754525
3detection of temperature stimulus involved in sensory perception of pain (GO:0050965)5.87812484
4detection of temperature stimulus involved in sensory perception (GO:0050961)5.87812484
5detection of temperature stimulus (GO:0016048)5.63879821
6negative regulation of dendrite morphogenesis (GO:0050774)5.53865175
7neurofilament cytoskeleton organization (GO:0060052)5.49457434
8cell migration in hindbrain (GO:0021535)5.25254428
9sympathetic nervous system development (GO:0048485)5.18544488
10bundle of His cell to Purkinje myocyte communication (GO:0086069)5.08151818
11cartilage morphogenesis (GO:0060536)4.98352628
12regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.67461201
13cell migration involved in heart development (GO:0060973)4.59477214
14cell communication involved in cardiac conduction (GO:0086065)4.47329824
15plasma membrane repair (GO:0001778)4.45371677
16negative regulation of microtubule polymerization (GO:0031115)4.35174531
17regulation of cardioblast differentiation (GO:0051890)4.30048900
18peripheral nervous system neuron development (GO:0048935)4.20487251
19neuronal action potential (GO:0019228)4.15794857
20regulation of secondary heart field cardioblast proliferation (GO:0003266)4.13661589
21regulation of cardioblast proliferation (GO:0003264)4.13661589
22negative regulation of striated muscle cell apoptotic process (GO:0010664)3.96764161
23phenol-containing compound catabolic process (GO:0019336)3.96658025
24endocardial cushion morphogenesis (GO:0003203)3.87427359
25proline transport (GO:0015824)3.81409719
26desmosome organization (GO:0002934)3.76459598
27negative regulation of dendrite development (GO:2000171)3.75467596
28layer formation in cerebral cortex (GO:0021819)3.71288531
29coronary vasculature morphogenesis (GO:0060977)3.71136885
30behavioral response to ethanol (GO:0048149)3.68518690
31membrane budding (GO:0006900)3.65637004
32behavioral response to nicotine (GO:0035095)3.56702727
33cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.53836047
34membrane depolarization during action potential (GO:0086010)3.46957674
35cell communication by electrical coupling (GO:0010644)3.42728280
36synaptic vesicle maturation (GO:0016188)3.41804977
37positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.41022058
38potassium ion export (GO:0071435)3.39660670
39calcium-mediated signaling using intracellular calcium source (GO:0035584)3.39515198
40outflow tract septum morphogenesis (GO:0003148)3.37366125
41intestinal absorption (GO:0050892)3.32231334
42positive regulation of axon extension (GO:0045773)3.30650227
43positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.29595583
44membrane repolarization (GO:0086009)3.28603894
45positive regulation of transcription regulatory region DNA binding (GO:2000679)3.27925755
46mitochondrion transport along microtubule (GO:0047497)3.27387706
47establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.27387706
48neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.26830307
49retinal ganglion cell axon guidance (GO:0031290)3.24207773
50establishment of mitochondrion localization (GO:0051654)3.23612773
51regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.22548627
52intermediate filament organization (GO:0045109)3.19736054
53negative regulation of calcium ion transport into cytosol (GO:0010523)3.19536971
54regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.19126683
55regulation of cardiac muscle cell apoptotic process (GO:0010665)3.17581214
56activation of protein kinase A activity (GO:0034199)3.15707134
57glutamate secretion (GO:0014047)3.14108702
58axon cargo transport (GO:0008088)3.12965076
59positive regulation of potassium ion transmembrane transport (GO:1901381)3.12526046
60enteric nervous system development (GO:0048484)3.12372203
61negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.11820721
62mesenchyme morphogenesis (GO:0072132)3.10590714
63behavioral response to pain (GO:0048266)3.09756133
64response to pain (GO:0048265)3.09389842
65mesenchymal cell proliferation (GO:0010463)3.08639057
66axon extension (GO:0048675)3.08519116
67membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.06877260
68embryonic heart tube development (GO:0035050)3.06121644
69negative regulation of potassium ion transmembrane transport (GO:1901380)3.04970750
70response to water (GO:0009415)3.04024801
71sodium ion export (GO:0071436)3.03115671
72regulation of early endosome to late endosome transport (GO:2000641)3.01175380
73organelle transport along microtubule (GO:0072384)2.95735527
74urinary tract smooth muscle contraction (GO:0014848)2.93558647
75positive regulation of dendritic spine morphogenesis (GO:0061003)2.93144344
76protein retention in ER lumen (GO:0006621)2.90685358
77protein targeting to plasma membrane (GO:0072661)2.90063708
78vitamin transmembrane transport (GO:0035461)2.89898678
79pyrimidine nucleobase catabolic process (GO:0006208)2.88584300
80negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.86953473
81action potential (GO:0001508)2.86296828
82negative regulation of protein polymerization (GO:0032272)2.86209119
83endocardial cushion development (GO:0003197)2.86179218
84synaptic vesicle exocytosis (GO:0016079)2.83838104
85norepinephrine metabolic process (GO:0042415)2.82466657
86adult heart development (GO:0007512)2.81723086
87regulation of synapse structural plasticity (GO:0051823)2.81713311
88regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.81031235
89vesicle transport along microtubule (GO:0047496)2.81007916
90regulation of synaptic vesicle exocytosis (GO:2000300)2.80808538
91neuron projection extension (GO:1990138)2.80794689
92dopamine receptor signaling pathway (GO:0007212)2.80061918
93negative regulation of homotypic cell-cell adhesion (GO:0034111)2.79613935
94regulation of heart morphogenesis (GO:2000826)2.78333717
95adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.77070677
96suckling behavior (GO:0001967)2.76931734
97regulation of short-term neuronal synaptic plasticity (GO:0048172)2.76884248
98skeletal muscle organ development (GO:0060538)2.76817881
99dopaminergic neuron differentiation (GO:0071542)2.76334245
100positive regulation of cardiac muscle hypertrophy (GO:0010613)2.75901769
101positive regulation of muscle hypertrophy (GO:0014742)2.75901769
102atrial septum morphogenesis (GO:0060413)2.75892856
103cytoskeletal anchoring at plasma membrane (GO:0007016)2.74708204
104intermediate filament cytoskeleton organization (GO:0045104)2.74665462
105urea metabolic process (GO:0019627)2.74659512
106negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.73961095
107positive regulation of synaptic transmission, GABAergic (GO:0032230)2.73523079
108positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.73491331
109cell junction maintenance (GO:0034331)2.73090382
110intermediate filament-based process (GO:0045103)2.71706485
111regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.71442373
112regulation of sodium ion transmembrane transporter activity (GO:2000649)2.71440045
113urea cycle (GO:0000050)2.71360460
114regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.70728491
115innervation (GO:0060384)2.70289251
116gap junction assembly (GO:0016264)2.70046135
117membrane repolarization during action potential (GO:0086011)2.69750791
118ventricular cardiac muscle cell action potential (GO:0086005)2.69653962
119actin filament depolymerization (GO:0030042)2.69275241
120cardiac right ventricle morphogenesis (GO:0003215)2.68741429
121actin filament capping (GO:0051693)2.68596822
122lung epithelium development (GO:0060428)2.67864055
123negative regulation of sodium ion transport (GO:0010766)2.67732829
124cellular glucuronidation (GO:0052695)2.67576431
125peptidyl-tyrosine autophosphorylation (GO:0038083)2.65147651
126regulation of potassium ion transmembrane transporter activity (GO:1901016)2.64692318
127auditory behavior (GO:0031223)2.63928807
128dendrite morphogenesis (GO:0048813)2.63591269
129regulation of membrane repolarization (GO:0060306)2.62554183
130very-low-density lipoprotein particle assembly (GO:0034379)2.62065987
131maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.60448975
132regulation of heart rate by cardiac conduction (GO:0086091)2.56000434
133negative regulation of catenin import into nucleus (GO:0035414)2.55504177
134regulation of cell communication by electrical coupling (GO:0010649)2.54987508
135nucleobase catabolic process (GO:0046113)2.54910563
136regulation of potassium ion transmembrane transport (GO:1901379)2.54074411
137regulation of axon extension (GO:0030516)2.53952422
138NADH metabolic process (GO:0006734)2.53849735
139hormone catabolic process (GO:0042447)2.53093104
140neuronal action potential propagation (GO:0019227)2.52849780
141glucuronate metabolic process (GO:0019585)2.52803449
142uronic acid metabolic process (GO:0006063)2.52803449
143cellular component maintenance (GO:0043954)2.51564253
144angiotensin maturation (GO:0002003)2.50716787
145negative regulation of actin filament polymerization (GO:0030837)2.50388830
146cellular response to prostaglandin stimulus (GO:0071379)2.49470003
147epoxygenase P450 pathway (GO:0019373)2.49383869
148regulation of striated muscle cell apoptotic process (GO:0010662)2.48838880
149axon extension involved in axon guidance (GO:0048846)2.48651728
150neuron projection extension involved in neuron projection guidance (GO:1902284)2.48651728
151cellular response to nicotine (GO:0071316)2.48524435
152positive regulation of axonogenesis (GO:0050772)2.48024403
153negative regulation of cation channel activity (GO:2001258)2.47642216
154negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.46790955
155atrioventricular valve morphogenesis (GO:0003181)2.46786909
156regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.46410380
157endocrine process (GO:0050886)2.46410380
158regulation of systemic arterial blood pressure by hormone (GO:0001990)2.46410380
159regulation of bile acid biosynthetic process (GO:0070857)2.46270722
160mesoderm formation (GO:0001707)2.46096556
161catecholamine biosynthetic process (GO:0042423)2.45814499
162catechol-containing compound biosynthetic process (GO:0009713)2.45814499
163polyketide metabolic process (GO:0030638)2.45643258
164doxorubicin metabolic process (GO:0044598)2.45643258
165daunorubicin metabolic process (GO:0044597)2.45643258
166positive regulation of potassium ion transport (GO:0043268)2.44920281
167tongue development (GO:0043586)2.43317889
168plasma lipoprotein particle assembly (GO:0034377)2.38958680
169drinking behavior (GO:0042756)2.38219215
170regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.35829123
171nitrogen cycle metabolic process (GO:0071941)2.35501754
172renal system process involved in regulation of blood volume (GO:0001977)2.34802173
173positive regulation of synapse maturation (GO:0090129)2.32911094
174catecholamine transport (GO:0051937)2.32373348
175lung vasculature development (GO:0060426)2.32127662
176regulation of guanylate cyclase activity (GO:0031282)2.30957733
177epithelial cell-cell adhesion (GO:0090136)2.29737587
178semaphorin-plexin signaling pathway (GO:0071526)2.29007359
179ganglion development (GO:0061548)2.28788280
180heart valve morphogenesis (GO:0003179)2.28413860
181flavonoid metabolic process (GO:0009812)2.27725719
182renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.27718198
183protein carboxylation (GO:0018214)2.27007759
184peptidyl-glutamic acid carboxylation (GO:0017187)2.27007759
185cardiac septum morphogenesis (GO:0060411)2.26251040
186ectodermal placode formation (GO:0060788)2.26098915

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF263_19887448_ChIP-Seq_K562_Human2.80717209
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.64161543
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.60150627
4JARID2_20075857_ChIP-Seq_MESCs_Mouse2.59948071
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.58862147
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.57531143
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.57531143
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.46885925
9EZH2_22144423_ChIP-Seq_EOC_Human2.46492117
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.37013047
11MTF2_20144788_ChIP-Seq_MESCs_Mouse2.29505192
12CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.27522557
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.20533177
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.17347114
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.15337164
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.13222037
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.10660939
18PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.09688350
19ESR1_20079471_ChIP-ChIP_T-47D_Human2.08027897
20ESR2_21235772_ChIP-Seq_MCF-7_Human2.07538549
21PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.98296701
22EZH2_27294783_Chip-Seq_ESCs_Mouse1.95606954
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.92932311
24EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.92294551
25SUZ12_27294783_Chip-Seq_ESCs_Mouse1.90607208
26RNF2_27304074_Chip-Seq_ESCs_Mouse1.83147773
27KDM2B_26808549_Chip-Seq_K562_Human1.77813930
28* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.76089423
29EP300_21415370_ChIP-Seq_HL-1_Mouse1.71370277
30ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.71132037
31ZFP281_18757296_ChIP-ChIP_E14_Mouse1.70830990
32NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.70531419
33NR3C1_23031785_ChIP-Seq_PC12_Mouse1.65963810
34CLOCK_20551151_ChIP-Seq_293T_Human1.62623199
35RBPJ_22232070_ChIP-Seq_NCS_Mouse1.62503109
36SMAD_19615063_ChIP-ChIP_OVARY_Human1.58516631
37REST_21632747_ChIP-Seq_MESCs_Mouse1.54679041
38ERG_21242973_ChIP-ChIP_JURKAT_Human1.53586817
39GBX2_23144817_ChIP-Seq_PC3_Human1.52606729
40WT1_19549856_ChIP-ChIP_CCG9911_Human1.52090510
41TP63_17297297_ChIP-ChIP_HaCaT_Human1.51925168
42BMI1_23680149_ChIP-Seq_NPCS_Mouse1.51839476
43CTCF_27219007_Chip-Seq_Bcells_Human1.49614504
44NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.49210963
45RXR_22158963_ChIP-Seq_LIVER_Mouse1.48214466
46STAT6_21828071_ChIP-Seq_BEAS2B_Human1.47366151
47AHR_22903824_ChIP-Seq_MCF-7_Human1.46968898
48* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.46392575
49CBX2_27304074_Chip-Seq_ESCs_Mouse1.44481089
50PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.44367773
51EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.42958306
52TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.42814755
53TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.41360071
54ISL1_27105846_Chip-Seq_CPCs_Mouse1.41198633
55REST_18959480_ChIP-ChIP_MESCs_Mouse1.37165480
56KDM2B_26808549_Chip-Seq_SUP-B15_Human1.36485683
57RING1B_27294783_Chip-Seq_ESCs_Mouse1.35859548
58DROSHA_22980978_ChIP-Seq_HELA_Human1.34399132
59WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.32414406
60ESR1_15608294_ChIP-ChIP_MCF-7_Human1.27320814
61ZNF274_21170338_ChIP-Seq_K562_Hela1.26882566
62* RARB_27405468_Chip-Seq_BRAIN_Mouse1.25670923
63TET1_21451524_ChIP-Seq_MESCs_Mouse1.23993784
64SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.23640510
65TCF4_18268006_ChIP-ChIP_LS174T_Human1.23329323
66FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.22414523
67ZNF217_24962896_ChIP-Seq_MCF-7_Human1.21715937
68TP53_20018659_ChIP-ChIP_R1E_Mouse1.21281718
69* RACK7_27058665_Chip-Seq_MCF-7_Human1.20398536
70VDR_22108803_ChIP-Seq_LS180_Human1.19407335
71MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.18817183
72* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.18627938
73ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.17285424
74ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.16623856
75TRIM28_21343339_ChIP-Seq_HEK293_Human1.16435098
76POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.16157105
77* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.15852508
78TET1_21490601_ChIP-Seq_MESCs_Mouse1.15314701
79NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.15205083
80PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.13639205
81ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.13329113
82WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13159622
83PPARA_22158963_ChIP-Seq_LIVER_Mouse1.13148494
84SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.12452724
85SRY_22984422_ChIP-ChIP_TESTIS_Rat1.11569546
86HIF1A_21447827_ChIP-Seq_MCF-7_Human1.11406762
87SOX2_20726797_ChIP-Seq_SW620_Human1.09948354
88SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09779100
89KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.08782884
90SMAD4_21741376_ChIP-Seq_HESCs_Human1.08554477
91DNAJC2_21179169_ChIP-ChIP_NT2_Human1.08005278
92PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.07361892
93SMAD4_21799915_ChIP-Seq_A2780_Human1.07227492
94SOX2_27498859_Chip-Seq_STOMACH_Mouse1.06778128
95RING1B_27294783_Chip-Seq_NPCs_Mouse1.06012043
96IKZF1_21737484_ChIP-ChIP_HCT116_Human1.05800606
97ARNT_22903824_ChIP-Seq_MCF-7_Human1.05746992
98TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05546680
99UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.05442278
100NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.03311181
101P300_27058665_Chip-Seq_ZR-75-30cells_Human1.03198281
102ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.03068773
103RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.02645372
104* ELK3_25401928_ChIP-Seq_HUVEC_Human1.02024519
105STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.01946007
106FOXA2_19822575_ChIP-Seq_HepG2_Human1.01425953
107CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.00965592
108EGR1_19032775_ChIP-ChIP_M12_Human1.00244622
109GATA2_21666600_ChIP-Seq_HMVEC_Human1.00224932
110ZFP281_27345836_Chip-Seq_ESCs_Mouse1.00182839
111CDX2_20551321_ChIP-Seq_CACO-2_Human0.99694039
112JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.99516669
113GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.97679089
114SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97195170
115LXR_22292898_ChIP-Seq_THP-1_Human0.96681416
116RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.96229793
117* GATA4_25053715_ChIP-Seq_YYC3_Human0.96188513
118NFIB_24661679_ChIP-Seq_LUNG_Mouse0.96139528
119TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.95956013
120GATA1_26923725_Chip-Seq_HPCs_Mouse0.95798284
121SOX2_21211035_ChIP-Seq_LN229_Gbm0.95316061
122SMAD3_21741376_ChIP-Seq_ESCs_Human0.93592515
123SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.93537782
124CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.93016777
125SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.92673890
126CTBP2_25329375_ChIP-Seq_LNCAP_Human0.92015188
127BCAT_22108803_ChIP-Seq_LS180_Human0.91063260
128TAF15_26573619_Chip-Seq_HEK293_Human0.91038776
129RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.90955061
130ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.90740613
131ESR1_21235772_ChIP-Seq_MCF-7_Human0.89969303
132KLF5_25053715_ChIP-Seq_YYC3_Human0.89930772
133RNF2_27304074_Chip-Seq_NSC_Mouse0.89001357
134AR_21572438_ChIP-Seq_LNCaP_Human0.88465938
135CJUN_26792858_Chip-Seq_BT549_Human0.88325962
136AR_19668381_ChIP-Seq_PC3_Human0.86438914
137SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.86296353

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002735_abnormal_chemical_nociception6.08478796
2MP0001968_abnormal_touch/_nociception5.20705393
3MP0002736_abnormal_nociception_after4.83342751
4MP0004270_analgesia4.22671060
5MP0004858_abnormal_nervous_system4.07044215
6MP0003567_abnormal_fetal_cardiomyocyte3.85502113
7MP0002733_abnormal_thermal_nociception3.62467341
8MP0002734_abnormal_mechanical_nocicepti3.51152099
9MP0004264_abnormal_extraembryonic_tissu3.36591722
10MP0006276_abnormal_autonomic_nervous3.15067007
11MP0001970_abnormal_pain_threshold2.88510009
12MP0005360_urolithiasis2.82075563
13MP0004859_abnormal_synaptic_plasticity2.80735518
14MP0001986_abnormal_taste_sensitivity2.72453539
15MP0002139_abnormal_hepatobiliary_system2.60568781
16MP0005409_darkened_coat_color2.40918243
17MP0002638_abnormal_pupillary_reflex2.28827902
18MP0005085_abnormal_gallbladder_physiolo2.26978237
19MP0010234_abnormal_vibrissa_follicle2.14494395
20MP0005167_abnormal_blood-brain_barrier2.11877702
21MP0002184_abnormal_innervation2.07411503
22MP0000751_myopathy1.87211770
23MP0010368_abnormal_lymphatic_system1.85430870
24MP0003122_maternal_imprinting1.84185839
25MP0004084_abnormal_cardiac_muscle1.83841348
26MP0010386_abnormal_urinary_bladder1.80209981
27MP0001666_abnormal_nutrient_absorption1.76448039
28MP0000537_abnormal_urethra_morphology1.76196617
29MP0003868_abnormal_feces_composition1.67636683
30MP0003635_abnormal_synaptic_transmissio1.66310803
31MP0002751_abnormal_autonomic_nervous1.65253947
32MP0005365_abnormal_bile_salt1.64260174
33MP0000566_synostosis1.62949780
34MP0004147_increased_porphyrin_level1.61789690
35MP0009379_abnormal_foot_pigmentation1.61474130
36MP0008438_abnormal_cutaneous_collagen1.61263999
37MP0001879_abnormal_lymphatic_vessel1.57566636
38MP0002837_dystrophic_cardiac_calcinosis1.56659156
39MP0004215_abnormal_myocardial_fiber1.48422941
40MP0000778_abnormal_nervous_system1.48222286
41MP0003329_amyloid_beta_deposits1.46948239
42MP0004811_abnormal_neuron_physiology1.44337710
43MP0002067_abnormal_sensory_capabilities1.43554401
44MP0003705_abnormal_hypodermis_morpholog1.41606943
45MP0002972_abnormal_cardiac_muscle1.40455036
46MP0004272_abnormal_basement_membrane1.39256550
47MP0002009_preneoplasia1.36543484
48MP0004085_abnormal_heartbeat1.36284266
49MP0003880_abnormal_central_pattern1.36190357
50MP0005257_abnormal_intraocular_pressure1.36160671
51MP0004036_abnormal_muscle_relaxation1.31829528
52MP0002063_abnormal_learning/memory/cond1.29374233
53MP0000955_abnormal_spinal_cord1.28734971
54MP0002272_abnormal_nervous_system1.28515927
55MP0009384_cardiac_valve_regurgitation1.26795988
56MP0004484_altered_response_of1.24126452
57MP0008775_abnormal_heart_ventricle1.23493487
58MP0005187_abnormal_penis_morphology1.21444079
59MP0003937_abnormal_limbs/digits/tail_de1.20817587
60MP0000049_abnormal_middle_ear1.19949937
61MP0000534_abnormal_ureter_morphology1.17987262
62MP0000749_muscle_degeneration1.17157350
63MP0003942_abnormal_urinary_system1.16491595
64MP0001270_distended_abdomen1.15755523
65MP0001529_abnormal_vocalization1.10085377
66MP0000372_irregular_coat_pigmentation1.09634074
67MP0002909_abnormal_adrenal_gland1.09399136
68MP0005423_abnormal_somatic_nervous1.07220950
69MP0003941_abnormal_skin_development1.04618125
70MP0002697_abnormal_eye_size1.03601710
71MP0009780_abnormal_chondrocyte_physiolo1.03568553
72MP0003115_abnormal_respiratory_system1.03156493
73MP0000762_abnormal_tongue_morphology0.98658887
74MP0002249_abnormal_larynx_morphology0.97125068
75MP0005620_abnormal_muscle_contractility0.94459747
76MP0002882_abnormal_neuron_morphology0.94455043
77MP0006138_congestive_heart_failure0.94408009
78MP0001544_abnormal_cardiovascular_syste0.91576441
79MP0005385_cardiovascular_system_phenoty0.91576441
80MP0003315_abnormal_perineum_morphology0.91471287
81MP0009745_abnormal_behavioral_response0.90355858
82MP0005623_abnormal_meninges_morphology0.89800873
83MP0005503_abnormal_tendon_morphology0.89646321
84MP0005275_abnormal_skin_tensile0.89364812
85MP0003119_abnormal_digestive_system0.88501960
86MP0001348_abnormal_lacrimal_gland0.87809656
87MP0004087_abnormal_muscle_fiber0.86533428
88MP0008872_abnormal_physiological_respon0.86420278
89MP0002102_abnormal_ear_morphology0.86163353
90MP0004782_abnormal_surfactant_physiolog0.84924795
91MP0003283_abnormal_digestive_organ0.84212757
92MP0002572_abnormal_emotion/affect_behav0.83892211
93MP0001984_abnormal_olfaction0.83244073
94MP0003935_abnormal_craniofacial_develop0.83221803
95MP0000538_abnormal_urinary_bladder0.81633247
96MP0004145_abnormal_muscle_electrophysio0.80345376
97MP0001440_abnormal_grooming_behavior0.80188870
98MP0002064_seizures0.79859561
99MP0000477_abnormal_intestine_morphology0.78995115
100MP0010030_abnormal_orbit_morphology0.77710515
101MP0001664_abnormal_digestion0.77660074
102MP0003646_muscle_fatigue0.77428825
103MP0010329_abnormal_lipoprotein_level0.76549983
104MP0003137_abnormal_impulse_conducting0.76468529
105MP0009046_muscle_twitch0.75859053
106MP0009840_abnormal_foam_cell0.75727936
107MP0005197_abnormal_uvea_morphology0.74940831
108MP0000747_muscle_weakness0.74859279
109MP0001905_abnormal_dopamine_level0.74792983
110MP0001299_abnormal_eye_distance/0.73935878
111MP0003385_abnormal_body_wall0.71298393
112MP0003861_abnormal_nervous_system0.71113274
113MP0004233_abnormal_muscle_weight0.70502738
114MP0005330_cardiomyopathy0.70173321
115MP0001188_hyperpigmentation0.69690169
116MP0000462_abnormal_digestive_system0.69650335
117MP0010771_integument_phenotype0.69546084
118MP0002557_abnormal_social/conspecific_i0.68176118
119MP0004924_abnormal_behavior0.67928836
120MP0005386_behavior/neurological_phenoty0.67928836
121MP0000013_abnormal_adipose_tissue0.67508279
122MP0002089_abnormal_postnatal_growth/wei0.67191425
123MP0003755_abnormal_palate_morphology0.67046820
124MP0000516_abnormal_urinary_system0.66444009
125MP0005367_renal/urinary_system_phenotyp0.66444009
126MP0002932_abnormal_joint_morphology0.65670080
127MP0010630_abnormal_cardiac_muscle0.65205143
128MP0002127_abnormal_cardiovascular_syste0.64973427
129MP0004510_myositis0.64939459
130MP0002233_abnormal_nose_morphology0.63369606
131MP0000759_abnormal_skeletal_muscle0.63096450
132MP0002066_abnormal_motor_capabilities/c0.62819864
133MP0001756_abnormal_urination0.62142918
134MP0001849_ear_inflammation0.62015009
135MP0002822_catalepsy0.61576732
136MP0002752_abnormal_somatic_nervous0.61497409
137MP0004019_abnormal_vitamin_homeostasis0.60958880
138MP0003633_abnormal_nervous_system0.59373622
139MP0002084_abnormal_developmental_patter0.58774549
140MP0005670_abnormal_white_adipose0.58668336
141MP0003279_aneurysm0.58379814
142MP0004883_abnormal_blood_vessel0.58219120
143MP0001340_abnormal_eyelid_morphology0.57318548
144MP0002069_abnormal_eating/drinking_beha0.57170825
145MP0002796_impaired_skin_barrier0.56776132
146MP0000579_abnormal_nail_morphology0.56645534
147MP0000230_abnormal_systemic_arterial0.54869048
148MP0003221_abnormal_cardiomyocyte_apopto0.54630216
149MP0003828_pulmonary_edema0.51921130
150MP0000767_abnormal_smooth_muscle0.51726447

Predicted human phenotypes

RankGene SetZ-score
1Ulnar claw (HP:0001178)6.57378781
2Hypothermia (HP:0002045)5.13656757
3Myokymia (HP:0002411)4.99263290
4Insidious onset (HP:0003587)4.69794927
5Termporal pattern (HP:0011008)4.69794927
6Neonatal hypoglycemia (HP:0001998)4.40112575
7Action tremor (HP:0002345)3.93184624
8Impaired pain sensation (HP:0007328)3.89422413
9Abnormality of pain sensation (HP:0010832)3.89422413
10Pheochromocytoma (HP:0002666)3.80862991
11Segmental peripheral demyelination/remyelination (HP:0003481)3.62088258
12Neuroendocrine neoplasm (HP:0100634)3.38393492
13Abnormality of glutamine family amino acid metabolism (HP:0010902)3.32536844
14Decreased number of large peripheral myelinated nerve fibers (HP:0003387)3.29224153
15Dysautonomia (HP:0002459)3.27640846
16Myotonia (HP:0002486)3.25452174
17Foot dorsiflexor weakness (HP:0009027)3.24946541
18Facial shape deformation (HP:0011334)3.24572552
19Ankle clonus (HP:0011448)3.18295431
20Steppage gait (HP:0003376)3.17094458
21Hyporeflexia of lower limbs (HP:0002600)3.14753052
22Hammertoe (HP:0001765)3.14313103
23Decreased number of peripheral myelinated nerve fibers (HP:0003380)3.08928305
24Abnormality of the vocal cords (HP:0008777)3.06945450
25Ventricular fibrillation (HP:0001663)3.06202966
26Abnormality of the foot musculature (HP:0001436)3.04658329
27Sudden death (HP:0001699)3.02508483
28Deep venous thrombosis (HP:0002625)2.96578051
29Bicornuate uterus (HP:0000813)2.96181412
30Supranuclear gaze palsy (HP:0000605)2.95601852
31Orthostatic hypotension (HP:0001278)2.92682042
32Atonic seizures (HP:0010819)2.80084171
33Focal seizures (HP:0007359)2.73165602
34Distal arthrogryposis (HP:0005684)2.72710353
35Protrusio acetabuli (HP:0003179)2.70932979
36Abnormality of monocarboxylic acid metabolism (HP:0010996)2.62879545
37Premature rupture of membranes (HP:0001788)2.60341476
38Hypoplasia of the brainstem (HP:0002365)2.58609513
39Aplasia/Hypoplasia of the brainstem (HP:0007362)2.58609513
40Abnormality of the phalanges of the 2nd finger (HP:0009541)2.57406169
41Flat acetabular roof (HP:0003180)2.55405583
42Limb dystonia (HP:0002451)2.55134829
43Hypercortisolism (HP:0001578)2.49301698
44Neoplasm of the peripheral nervous system (HP:0100007)2.48108158
45Shawl scrotum (HP:0000049)2.47459400
46Disproportionate tall stature (HP:0001519)2.47365667
47Turricephaly (HP:0000262)2.42299322
48Abnormality of calcium-phosphate metabolism (HP:0100530)2.41120905
49Failure to thrive in infancy (HP:0001531)2.40913306
50Partial duplication of the phalanx of hand (HP:0009999)2.40348206
51Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.40238166
52Hemorrhage of the eye (HP:0011885)2.37583194
53Palpitations (HP:0001962)2.36297079
54Cerebral hemorrhage (HP:0001342)2.35683041
55Abnormal pancreas size (HP:0012094)2.34879533
56Hypobetalipoproteinemia (HP:0003563)2.34697230
57Right ventricular cardiomyopathy (HP:0011663)2.32672359
58Bundle branch block (HP:0011710)2.32123072
59Hypoventilation (HP:0002791)2.29087063
60Hypotension (HP:0002615)2.28228975
61Abnormal tarsal ossification (HP:0008369)2.27529004
62Asymmetry of the thorax (HP:0001555)2.27416594
63Syncope (HP:0001279)2.24515392
64Decreased motor nerve conduction velocity (HP:0003431)2.23118979
65Distal sensory impairment (HP:0002936)2.22915067
66Thin bony cortex (HP:0002753)2.22558547
67Rapidly progressive (HP:0003678)2.22416199
68Thyroid carcinoma (HP:0002890)2.18789672
69Urinary urgency (HP:0000012)2.15481949
70Aplasia involving bones of the extremities (HP:0009825)2.14757615
71Aplasia involving bones of the upper limbs (HP:0009823)2.14757615
72Aplasia of the phalanges of the hand (HP:0009802)2.14757615
73Coronal craniosynostosis (HP:0004440)2.14535502
74Patent foramen ovale (HP:0001655)2.13304280
75Bradycardia (HP:0001662)2.11731573
76Wrist flexion contracture (HP:0001239)2.09679856
77Abnormality of the phalanges of the hallux (HP:0010057)2.09249929
78Abnormality of the corticospinal tract (HP:0002492)2.09044189
79Curly hair (HP:0002212)2.07145414
80Neonatal short-limb short stature (HP:0008921)2.06344917
81Abnormality of the 2nd finger (HP:0004100)2.05889767
82Areflexia of lower limbs (HP:0002522)2.04847240
83Onion bulb formation (HP:0003383)2.04635169
84Abnormality of the lower motor neuron (HP:0002366)2.04598266
85Wide cranial sutures (HP:0010537)2.04522355
86Bowel diverticulosis (HP:0005222)2.03795548
87Prolonged QT interval (HP:0001657)2.03608069
88Insomnia (HP:0100785)2.03304472
89Ventricular tachycardia (HP:0004756)2.02491650
90Abnormality of carpal bone ossification (HP:0006257)2.02271121
91Mutism (HP:0002300)2.01641029
92Amblyopia (HP:0000646)2.01384175
93Difficulty climbing stairs (HP:0003551)1.99587632
94Apathy (HP:0000741)1.98440019
95Delayed epiphyseal ossification (HP:0002663)1.96368474
96Visual hallucinations (HP:0002367)1.95820986
97Myelomeningocele (HP:0002475)1.93937860
98Progressive cerebellar ataxia (HP:0002073)1.93737069
99Chin dimple (HP:0010751)1.92383166
100Mask-like facies (HP:0000298)1.91807049
101Distal lower limb muscle weakness (HP:0009053)1.91794454
102Cutaneous finger syndactyly (HP:0010554)1.90965218
103Annular pancreas (HP:0001734)1.89398689
104Bladder diverticulum (HP:0000015)1.89199705
105Lymphangioma (HP:0100764)1.86573643
106Arterial tortuosity (HP:0005116)1.86571915
107Abnormality of proline metabolism (HP:0010907)1.86527518
108Hydroxyprolinuria (HP:0003080)1.86527518
109Abnormality of the distal phalanx of the thumb (HP:0009617)1.85876858
110Abnormal autonomic nervous system physiology (HP:0012332)1.85411714
111Truncus arteriosus (HP:0001660)1.84401400
112Primary atrial arrhythmia (HP:0001692)1.84368467
113Thoracolumbar scoliosis (HP:0002944)1.82922842
114Lower limb muscle weakness (HP:0007340)1.82289225
115Osteomalacia (HP:0002749)1.81361198
116Midline defect of the nose (HP:0004122)1.80764330
117Cervical subluxation (HP:0003308)1.80655790
118Supraventricular arrhythmia (HP:0005115)1.80370140
119Partial duplication of thumb phalanx (HP:0009944)1.79796209
120Hyperparathyroidism (HP:0000843)1.78817215
121Hand muscle atrophy (HP:0009130)1.78344701
122Hypercalciuria (HP:0002150)1.77916211
123Widely patent fontanelles and sutures (HP:0004492)1.77368313
124Overlapping toe (HP:0001845)1.76792014
125Difficulty running (HP:0009046)1.75820121
126Shallow orbits (HP:0000586)1.75268840
127Increased connective tissue (HP:0009025)1.74502524
128Supraventricular tachycardia (HP:0004755)1.74447177
129Atrial fibrillation (HP:0005110)1.74265881
130Muscle fiber splitting (HP:0003555)1.74064987
131Enlarged penis (HP:0000040)1.73473597
132Conjunctival hamartoma (HP:0100780)1.73080680
133Bilateral microphthalmos (HP:0007633)1.72910754
134External ophthalmoplegia (HP:0000544)1.72741200
135Febrile seizures (HP:0002373)1.72647317
136Diminished motivation (HP:0000745)1.72406117
137Abnormality of the aortic arch (HP:0012303)1.71729273
138Vascular tortuosity (HP:0004948)1.71329463
139Abnormality of the parathyroid morphology (HP:0011766)1.71192625
140EMG: myopathic abnormalities (HP:0003458)1.71054388
141Visceral angiomatosis (HP:0100761)1.71044770
142Exotropia (HP:0000577)1.70560513
143Neonatal onset (HP:0003623)1.70384695
144Autoamputation (HP:0001218)1.70330998
145Abnormal ossification of hand bones (HP:0005921)1.70087157
146Abnormality of magnesium homeostasis (HP:0004921)1.69851955
147Torticollis (HP:0000473)1.69476141
148Conjugated hyperbilirubinemia (HP:0002908)1.68476152
149Cortical dysplasia (HP:0002539)1.68343208
150Increased variability in muscle fiber diameter (HP:0003557)1.68128315
151Truncal ataxia (HP:0002078)1.68057877
152Overgrowth (HP:0001548)1.67582542
153Muscle stiffness (HP:0003552)1.66834468
154Transposition of the great arteries (HP:0001669)1.66815855
155Abnormal connection of the cardiac segments (HP:0011545)1.66815855
156Abnormal ventriculo-arterial connection (HP:0011563)1.66815855
157Urinary bladder sphincter dysfunction (HP:0002839)1.65797543
158Lower limb asymmetry (HP:0100559)1.65729397
159Absent phalangeal crease (HP:0006109)1.65193335
160Absence seizures (HP:0002121)1.65041320
161Potter facies (HP:0002009)1.64368873
162Complement deficiency (HP:0004431)1.64021183
163Hemangiomatosis (HP:0007461)1.62109600
164Vascular calcification (HP:0004934)1.60240313
165Renovascular hypertension (HP:0100817)1.60071425
166Choanal stenosis (HP:0000452)1.59255043
167Fragile skin (HP:0001030)1.58954731
168Vitreoretinal degeneration (HP:0000655)1.58024838
169Long toe (HP:0010511)1.58009602
170Abnormal hand bone ossification (HP:0010660)1.57781800
171Cardiovascular calcification (HP:0011915)1.56020588
172Hypercalcemia (HP:0003072)1.55794349
173Renal duplication (HP:0000075)1.54936952
174Intrahepatic cholestasis (HP:0001406)1.54503852
175Hyperacusis (HP:0010780)1.54398498
176Focal segmental glomerulosclerosis (HP:0000097)1.53325409
177Absent eyebrow (HP:0002223)1.52733868
178Coarctation of aorta (HP:0001680)1.52033265
179Adducted thumb (HP:0001181)1.51121921
180Gout (HP:0001997)1.50959571
181Proximal tubulopathy (HP:0000114)1.50921591

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK44.95718410
2MAP3K93.78059811
3KSR23.66962006
4LMTK23.59114891
5NTRK13.35810361
6LATS23.21083696
7MARK12.95758576
8FLT32.93546247
9DDR22.84100094
10LIMK12.82405369
11MINK12.75495972
12CASK2.58382053
13EPHA22.53885596
14MAP3K22.44747470
15PHKG22.36484936
16PHKG12.36484936
17NTRK32.21236935
18TIE12.18317222
19RET2.02757323
20EPHB21.83895203
21KDR1.78985858
22MATK1.76604681
23FER1.74802672
24FGFR41.74252423
25ARAF1.71638966
26MAPKAPK31.69076818
27EEF2K1.67315514
28DYRK1B1.64988709
29GRK51.62314909
30ICK1.62236714
31BCR1.62111159
32PAK61.54450309
33PTK2B1.52656558
34PKN21.49634319
35MAP3K121.49174910
36TYRO31.40424587
37MAP2K11.39584250
38MAP3K101.39503212
39MAPK131.36558478
40MAP3K41.32886901
41TESK11.32862334
42SCYL21.32717221
43RIPK11.29205168
44MAP3K11.26870585
45DYRK21.24653575
46TRIB31.24096650
47PRKG21.23953263
48MAP2K21.19291892
49MAP2K41.18720808
50PRKD31.08541619
51MAP3K111.05814557
52RPS6KA21.05792029
53EPHA31.03579409
54KSR11.01856747
55NTRK20.96308163
56NEK10.95605773
57MAP3K60.94997599
58PTK20.94497297
59TAOK10.90505207
60CDK50.89138399
61CDK140.88234756
62PAK30.87893128
63DAPK20.82717584
64SIK10.77393552
65TGFBR10.76741059
66RIPK40.74261015
67CAMKK10.73971048
68FGFR10.73811011
69EPHA40.72889919
70MYLK0.72615503
71ERN10.71645194
72WNK40.71299374
73TESK20.70174380
74MAP2K70.64992770
75MST1R0.64926774
76SIK20.64431095
77MARK30.62845599
78CSNK1G20.62454708
79ROCK10.61515412
80STK390.60205330
81PIK3CA0.59359380
82BRAF0.58335039
83GRK70.56120509
84CDK180.54313343
85ILK0.53873770
86PDGFRA0.52988672
87PDK20.52498319
88CDK150.51919512
89LATS10.51673385
90ACVR1B0.50738094
91PAK40.50615073
92ADRBK10.49809285
93STK38L0.49618000
94PRKCE0.49354450
95STK240.49317477
96MAP2K60.49178028
97FRK0.48773175
98MTOR0.44914897
99SGK4940.44746817
100SGK2230.44746817
101CDC42BPA0.44625658
102FGFR20.44470761
103MET0.43611007
104CDK11A0.43392273
105INSRR0.43387539
106MARK20.43221622
107MAPK120.42745661
108CAMK2A0.42061545
109CAMK40.41336028
110PRKCZ0.40893438
111UHMK10.40788233
112ERBB20.40375796
113PRKACG0.40040552
114PRKAA10.39972363
115NME10.39781755
116CDK190.39079942
117DMPK0.38959220
118PTK60.38895375
119FGFR30.37921016
120PDPK10.37822927
121CSNK1E0.37806778
122PDK40.37711435
123PDK30.37711435
124CSNK1G30.37630763
125CSNK1A1L0.36033337
126SRC0.33917413
127RAF10.33596481
128CAMK2D0.33509617
129LRRK20.32538548
130DAPK30.32201168
131AKT30.32153035
132PRKD10.32056241
133STK380.31751844
134WNK10.31125696
135ROCK20.31099508
136MAP3K50.30941570
137PDGFRB0.30812173
138PRKCG0.30776716
139CSNK1G10.30399637
140CDK80.30006228
141PRKACA0.29501995
142PDK10.26444755
143ERBB40.25087391

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004603.04763859
2Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.98579902
3Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.60213011
4Fat digestion and absorption_Homo sapiens_hsa049752.57517364
5Arginine biosynthesis_Homo sapiens_hsa002202.32903865
6Synaptic vesicle cycle_Homo sapiens_hsa047212.30887502
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.28338759
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.05437494
9Pentose and glucuronate interconversions_Homo sapiens_hsa000401.97867542
10Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.91173481
11Olfactory transduction_Homo sapiens_hsa047401.85107829
12Phenylalanine metabolism_Homo sapiens_hsa003601.82355105
13Tyrosine metabolism_Homo sapiens_hsa003501.81436583
14Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.77001490
15Thyroid cancer_Homo sapiens_hsa052161.76284945
16Sulfur metabolism_Homo sapiens_hsa009201.73738310
17Vitamin digestion and absorption_Homo sapiens_hsa049771.71721748
18Fructose and mannose metabolism_Homo sapiens_hsa000511.69594784
19Starch and sucrose metabolism_Homo sapiens_hsa005001.67758269
20Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.67750852
21Cardiac muscle contraction_Homo sapiens_hsa042601.66696482
22Retinol metabolism_Homo sapiens_hsa008301.59471797
23Histidine metabolism_Homo sapiens_hsa003401.58290657
24Dorso-ventral axis formation_Homo sapiens_hsa043201.57892027
25Galactose metabolism_Homo sapiens_hsa000521.57667107
26Gap junction_Homo sapiens_hsa045401.50417788
27Dopaminergic synapse_Homo sapiens_hsa047281.49988342
28Long-term potentiation_Homo sapiens_hsa047201.48702843
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.46575933
30Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.46462876
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.45574837
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.43707336
33VEGF signaling pathway_Homo sapiens_hsa043701.42806287
34GnRH signaling pathway_Homo sapiens_hsa049121.42415143
35Axon guidance_Homo sapiens_hsa043601.41870881
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.40435249
37Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.40029462
38Chemical carcinogenesis_Homo sapiens_hsa052041.38383020
39Insulin secretion_Homo sapiens_hsa049111.38307037
40Endometrial cancer_Homo sapiens_hsa052131.37507205
41Taste transduction_Homo sapiens_hsa047421.37285586
42Caffeine metabolism_Homo sapiens_hsa002321.36272441
43Circadian entrainment_Homo sapiens_hsa047131.34883023
44Cholinergic synapse_Homo sapiens_hsa047251.32624952
45Glioma_Homo sapiens_hsa052141.32156355
46Sulfur relay system_Homo sapiens_hsa041221.28518020
47Salivary secretion_Homo sapiens_hsa049701.26789767
48Central carbon metabolism in cancer_Homo sapiens_hsa052301.26503500
49Cocaine addiction_Homo sapiens_hsa050301.26031144
50Neurotrophin signaling pathway_Homo sapiens_hsa047221.24269308
51Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.22497417
52Estrogen signaling pathway_Homo sapiens_hsa049151.20663434
53Gastric acid secretion_Homo sapiens_hsa049711.20621425
54Fatty acid degradation_Homo sapiens_hsa000711.20577156
55Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.18177566
56Mineral absorption_Homo sapiens_hsa049781.17689888
57PPAR signaling pathway_Homo sapiens_hsa033201.17298551
58Arginine and proline metabolism_Homo sapiens_hsa003301.16908373
59Melanogenesis_Homo sapiens_hsa049161.15975827
60Biosynthesis of amino acids_Homo sapiens_hsa012301.15387233
61Oocyte meiosis_Homo sapiens_hsa041141.15280602
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.12642528
63Tight junction_Homo sapiens_hsa045301.12583980
64Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.11821782
65Dilated cardiomyopathy_Homo sapiens_hsa054141.09669275
66Complement and coagulation cascades_Homo sapiens_hsa046101.09097387
67Carbohydrate digestion and absorption_Homo sapiens_hsa049731.08607042
68Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.08549550
69Drug metabolism - other enzymes_Homo sapiens_hsa009831.07017829
70Long-term depression_Homo sapiens_hsa047301.06854546
71Oxytocin signaling pathway_Homo sapiens_hsa049211.05506539
72Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.05426713
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.05038089
74Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.04104936
75Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.04025803
76Insulin signaling pathway_Homo sapiens_hsa049101.03646323
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.03630573
78Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.03570552
79Glutamatergic synapse_Homo sapiens_hsa047241.03274699
80Rap1 signaling pathway_Homo sapiens_hsa040151.02232829
81Endocytosis_Homo sapiens_hsa041440.99155322
82Aldosterone synthesis and secretion_Homo sapiens_hsa049250.99034338
83Parkinsons disease_Homo sapiens_hsa050120.98211867
84Salmonella infection_Homo sapiens_hsa051320.96157203
85Renin secretion_Homo sapiens_hsa049240.95837639
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.95275147
87Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.95256945
88cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95050320
89ErbB signaling pathway_Homo sapiens_hsa040120.94388120
90Maturity onset diabetes of the young_Homo sapiens_hsa049500.90145936
91Melanoma_Homo sapiens_hsa052180.89933029
92Carbon metabolism_Homo sapiens_hsa012000.88970099
93Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.88916477
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.87575954
95Type II diabetes mellitus_Homo sapiens_hsa049300.86906525
96Adherens junction_Homo sapiens_hsa045200.86720497
97Serotonergic synapse_Homo sapiens_hsa047260.85761466
98Vibrio cholerae infection_Homo sapiens_hsa051100.85017941
99Renal cell carcinoma_Homo sapiens_hsa052110.84995582
100Hippo signaling pathway_Homo sapiens_hsa043900.84575469
101Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.83647754
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.82625818
103Fatty acid metabolism_Homo sapiens_hsa012120.82492725
104GABAergic synapse_Homo sapiens_hsa047270.82457084
105Pyruvate metabolism_Homo sapiens_hsa006200.80639732
106Sphingolipid signaling pathway_Homo sapiens_hsa040710.80584552
107Morphine addiction_Homo sapiens_hsa050320.80576073
108ECM-receptor interaction_Homo sapiens_hsa045120.80157102
109Alzheimers disease_Homo sapiens_hsa050100.80007054
110Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.79809871
111Phosphatidylinositol signaling system_Homo sapiens_hsa040700.78829446
112Colorectal cancer_Homo sapiens_hsa052100.78694472
113mTOR signaling pathway_Homo sapiens_hsa041500.77993418
114Steroid biosynthesis_Homo sapiens_hsa001000.77599565
115Calcium signaling pathway_Homo sapiens_hsa040200.77517271
116Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.77465321
117Primary bile acid biosynthesis_Homo sapiens_hsa001200.76921052
118Bile secretion_Homo sapiens_hsa049760.76469277
119Tryptophan metabolism_Homo sapiens_hsa003800.76445275
120Choline metabolism in cancer_Homo sapiens_hsa052310.76329428
121Amphetamine addiction_Homo sapiens_hsa050310.75323663
122Hedgehog signaling pathway_Homo sapiens_hsa043400.75155314
123Collecting duct acid secretion_Homo sapiens_hsa049660.74803473
124Bladder cancer_Homo sapiens_hsa052190.73712910
125Renin-angiotensin system_Homo sapiens_hsa046140.73069683
126Oxidative phosphorylation_Homo sapiens_hsa001900.72549878
127Thyroid hormone synthesis_Homo sapiens_hsa049180.72495215
128Focal adhesion_Homo sapiens_hsa045100.71831192
129Butanoate metabolism_Homo sapiens_hsa006500.71662539
130Ras signaling pathway_Homo sapiens_hsa040140.70391600
131Prolactin signaling pathway_Homo sapiens_hsa049170.70278128
132Glycerolipid metabolism_Homo sapiens_hsa005610.70044538
133Pancreatic secretion_Homo sapiens_hsa049720.65103502
134AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64856842
135Protein digestion and absorption_Homo sapiens_hsa049740.64643682
136Nicotine addiction_Homo sapiens_hsa050330.64345847
137cAMP signaling pathway_Homo sapiens_hsa040240.64084474
138Viral myocarditis_Homo sapiens_hsa054160.62804858
139Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62226590
140Amoebiasis_Homo sapiens_hsa051460.61162968
141alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.60375217
142Huntingtons disease_Homo sapiens_hsa050160.60007686
143HIF-1 signaling pathway_Homo sapiens_hsa040660.59093458
144Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58771441
145Non-small cell lung cancer_Homo sapiens_hsa052230.58708209
146Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.57750885
147Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.57637565
148MAPK signaling pathway_Homo sapiens_hsa040100.57292953
149Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.55890367
150Vitamin B6 metabolism_Homo sapiens_hsa007500.55433558
151AMPK signaling pathway_Homo sapiens_hsa041520.55332324
152Linoleic acid metabolism_Homo sapiens_hsa005910.54486494
153Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.53070745
154Basal cell carcinoma_Homo sapiens_hsa052170.51751155
155Peroxisome_Homo sapiens_hsa041460.49383201
156Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.46216419
157Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44791693
158TGF-beta signaling pathway_Homo sapiens_hsa043500.42950273
159Sphingolipid metabolism_Homo sapiens_hsa006000.42741383
160Pentose phosphate pathway_Homo sapiens_hsa000300.42337829

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