DOK5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the DOK family of membrane proteins, which are adapter proteins involved in signal transduction. The encoded protein interacts with phosphorylated receptor tyrosine kinases to mediate neurite outgrowth and activation of the MAP kinase pathway. Unlike other DOK family proteins, this protein does not interact with RASGAP. This protein is up-regulated in patients with systemic sclerosis and is associated with fibrosis induced by insulin-like growth factor binding protein 5. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)5.66024701
2regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.11743542
3vocalization behavior (GO:0071625)5.02766648
4presynaptic membrane assembly (GO:0097105)5.02541550
5presynaptic membrane organization (GO:0097090)4.77161014
6protein localization to synapse (GO:0035418)4.76671066
7synaptic vesicle exocytosis (GO:0016079)4.64362579
8postsynaptic membrane organization (GO:0001941)4.63339411
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.51022079
10regulation of short-term neuronal synaptic plasticity (GO:0048172)4.49833019
11regulation of glutamate receptor signaling pathway (GO:1900449)4.48419791
12neuron recognition (GO:0008038)4.45982054
13ionotropic glutamate receptor signaling pathway (GO:0035235)4.36299761
14regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.31523674
15negative regulation of synaptic transmission, GABAergic (GO:0032229)4.26187204
16glutamate receptor signaling pathway (GO:0007215)4.21157887
17neurotransmitter-gated ion channel clustering (GO:0072578)4.16716619
18glutamate secretion (GO:0014047)4.14411140
19synaptic vesicle docking involved in exocytosis (GO:0016081)4.13847916
20regulation of synaptic vesicle exocytosis (GO:2000300)4.01607241
21axonal fasciculation (GO:0007413)4.00180197
22neuronal action potential propagation (GO:0019227)3.94755913
23synaptic transmission, glutamatergic (GO:0035249)3.93894292
24neuron-neuron synaptic transmission (GO:0007270)3.90707245
25startle response (GO:0001964)3.82534140
26gamma-aminobutyric acid signaling pathway (GO:0007214)3.81717817
27pyrimidine nucleobase catabolic process (GO:0006208)3.77992614
28positive regulation of synapse assembly (GO:0051965)3.74976982
29gamma-aminobutyric acid transport (GO:0015812)3.64406139
30G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.60547848
31cerebral cortex radially oriented cell migration (GO:0021799)3.60485541
32dendritic spine morphogenesis (GO:0060997)3.55335597
33locomotory exploration behavior (GO:0035641)3.51407853
34otic vesicle formation (GO:0030916)3.46761293
35regulation of synaptic vesicle transport (GO:1902803)3.46128837
36cell migration in hindbrain (GO:0021535)3.46081816
37regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.41814996
38membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.40483720
39central nervous system projection neuron axonogenesis (GO:0021952)3.39331846
40positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.38543050
41exploration behavior (GO:0035640)3.37207556
42positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.31828906
43olfactory bulb development (GO:0021772)3.31751975
44long-term synaptic potentiation (GO:0060291)3.31015834
45limb bud formation (GO:0060174)3.29323571
46transmission of nerve impulse (GO:0019226)3.29245399
47regulation of synapse assembly (GO:0051963)3.29019983
48regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.27649075
49regulation of long-term neuronal synaptic plasticity (GO:0048169)3.24020744
50regulation of excitatory postsynaptic membrane potential (GO:0060079)3.23745448
51layer formation in cerebral cortex (GO:0021819)3.22198153
52synapse assembly (GO:0007416)3.20456197
53response to histamine (GO:0034776)3.20215806
54synaptic vesicle maturation (GO:0016188)3.20023095
55regulation of synaptic transmission, glutamatergic (GO:0051966)3.18998971
56neurotransmitter secretion (GO:0007269)3.18841990
57righting reflex (GO:0060013)3.17048692
58regulation of neuronal synaptic plasticity (GO:0048168)3.16508208
59regulation of postsynaptic membrane potential (GO:0060078)3.15933247
60auditory behavior (GO:0031223)3.13758364
61positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.11710737
62positive regulation of membrane potential (GO:0045838)3.11092907
63dendrite development (GO:0016358)3.07641489
64mechanosensory behavior (GO:0007638)3.07391670
65nucleobase catabolic process (GO:0046113)3.07076150
66nonmotile primary cilium assembly (GO:0035058)3.06747641
67regulation of synapse structural plasticity (GO:0051823)3.05890872
68regulation of neurotransmitter secretion (GO:0046928)3.03484596
69cerebellar granule cell differentiation (GO:0021707)3.01012278
70regulation of respiratory system process (GO:0044065)2.99528071
71regulation of vesicle fusion (GO:0031338)2.98980614
72dendrite morphogenesis (GO:0048813)2.97592854
73positive regulation of synapse maturation (GO:0090129)2.97492481
74cochlea development (GO:0090102)2.96264187
75long-term memory (GO:0007616)2.95544511
76regulation of synapse organization (GO:0050807)2.93491323
77regulation of synaptic plasticity (GO:0048167)2.93467054
78positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.91242878
79cerebral cortex cell migration (GO:0021795)2.91084397
80negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.90503244
81regulation of dendritic spine morphogenesis (GO:0061001)2.89622236
82positive regulation of neurotransmitter secretion (GO:0001956)2.88573884
83regulation of synapse maturation (GO:0090128)2.88365096
84central nervous system neuron axonogenesis (GO:0021955)2.85350997
85learning (GO:0007612)2.81910796
86neurotransmitter transport (GO:0006836)2.81627802
87regulation of respiratory gaseous exchange (GO:0043576)2.81018568
88regulation of synaptic transmission, GABAergic (GO:0032228)2.80464079
89negative regulation of astrocyte differentiation (GO:0048712)2.79511865
90establishment of mitochondrion localization (GO:0051654)2.77708424
91innervation (GO:0060384)2.77242267
92regulation of dendritic spine development (GO:0060998)2.76932757
93negative regulation of axon guidance (GO:1902668)2.76280775
94regulation of inositol phosphate biosynthetic process (GO:0010919)2.75535681
95negative regulation of transcription regulatory region DNA binding (GO:2000678)2.75489978
96behavioral defense response (GO:0002209)2.75155029
97behavioral fear response (GO:0001662)2.75155029
98response to auditory stimulus (GO:0010996)2.74774452
99regulation of glutamate secretion (GO:0014048)2.74726157
100regulation of neurotransmitter transport (GO:0051588)2.74115296
101membrane depolarization (GO:0051899)2.73718651
102dermatan sulfate biosynthetic process (GO:0030208)2.73413341
103regulation of axon guidance (GO:1902667)2.72947525
104opioid receptor signaling pathway (GO:0038003)2.72153877
105calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.71595199
106synapse organization (GO:0050808)2.71291879
107regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.69713703
108negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.69373726
109positive regulation of synaptic transmission, GABAergic (GO:0032230)2.69120482
110regulation of timing of cell differentiation (GO:0048505)2.68699443
111cholesterol biosynthetic process (GO:0006695)2.68305886
112cerebellar Purkinje cell differentiation (GO:0021702)2.67809103
113synaptic transmission (GO:0007268)2.67137857
114fear response (GO:0042596)2.66274170
115proline transport (GO:0015824)2.66068119
116C4-dicarboxylate transport (GO:0015740)2.65159981
117retinal ganglion cell axon guidance (GO:0031290)2.64375796
118neuronal ion channel clustering (GO:0045161)2.64367364
119regulation of development, heterochronic (GO:0040034)2.62436807
120eye photoreceptor cell differentiation (GO:0001754)2.55715045
121photoreceptor cell differentiation (GO:0046530)2.55715045
122positive regulation of male gonad development (GO:2000020)2.46210107
123L-serine metabolic process (GO:0006563)2.44935181
124sterol biosynthetic process (GO:0016126)2.42572269
125membrane assembly (GO:0071709)2.41690867
126epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.40954201
127limb development (GO:0060173)2.40623515
128appendage development (GO:0048736)2.40623515
129axon extension (GO:0048675)2.40207748
130cilium morphogenesis (GO:0060271)2.40071002
131retinal rod cell development (GO:0046548)2.38568370
132intraciliary transport (GO:0042073)2.37835857
133protein polyglutamylation (GO:0018095)2.37610183
134dermatan sulfate metabolic process (GO:0030205)2.36537884
135DNA double-strand break processing (GO:0000729)2.36054865
136neuromuscular synaptic transmission (GO:0007274)2.35510124
137positive regulation of dendritic spine morphogenesis (GO:0061003)2.35480079
138negative regulation of protein localization to cell surface (GO:2000009)2.34494427
139cellular response to cholesterol (GO:0071397)2.34457418
140spinal cord development (GO:0021510)2.33418661
141serine family amino acid catabolic process (GO:0009071)2.31768385
142regulation of non-canonical Wnt signaling pathway (GO:2000050)2.31748917
143cell proliferation in forebrain (GO:0021846)2.31051796
144regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.30980847
145positive regulation of amino acid transport (GO:0051957)2.30943266
146neurotransmitter uptake (GO:0001504)2.29392487
147regulation of male gonad development (GO:2000018)2.28619381
148negative regulation of cytosolic calcium ion concentration (GO:0051481)2.28066227
149cellular response to sterol (GO:0036315)2.27362556
150amino acid import (GO:0043090)2.26242142
151ganglion development (GO:0061548)2.25437087
152regulation of axon extension involved in axon guidance (GO:0048841)2.25202756
153inner ear receptor stereocilium organization (GO:0060122)2.25144401
154axon extension involved in axon guidance (GO:0048846)2.24953905
155neuron projection extension involved in neuron projection guidance (GO:1902284)2.24953905
156regulation of cilium movement (GO:0003352)2.23317423
157regulation of cell communication by electrical coupling (GO:0010649)2.22903003
158telencephalon cell migration (GO:0022029)2.22579070
159regulation of cardiac muscle cell contraction (GO:0086004)2.21474469

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.39164367
2GBX2_23144817_ChIP-Seq_PC3_Human4.24035541
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.54446312
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.11219673
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.04077439
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.87677712
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.87580303
8SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.61573118
9EED_16625203_ChIP-ChIP_MESCs_Mouse2.60801645
10* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.58547135
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.55304564
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.54345483
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.54345483
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.52946988
15TAF15_26573619_Chip-Seq_HEK293_Human2.44354687
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.41546727
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.24918716
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.21074599
19* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.17284527
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.16856720
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.15857536
22* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.14644677
23* REST_21632747_ChIP-Seq_MESCs_Mouse2.14248568
24CBX2_27304074_Chip-Seq_ESCs_Mouse2.13571892
25EZH2_27294783_Chip-Seq_ESCs_Mouse2.11728795
26BMI1_23680149_ChIP-Seq_NPCS_Mouse2.10844653
27SUZ12_27294783_Chip-Seq_ESCs_Mouse2.08020110
28* AR_21572438_ChIP-Seq_LNCaP_Human1.99977929
29* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.97643468
30HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.90315591
31* P300_19829295_ChIP-Seq_ESCs_Human1.89734162
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.87505999
33TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.86140630
34PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.83577680
35* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.81341527
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.77816444
37POU3F2_20337985_ChIP-ChIP_501MEL_Human1.75689860
38RNF2_27304074_Chip-Seq_NSC_Mouse1.73462863
39SMAD4_21799915_ChIP-Seq_A2780_Human1.71818021
40RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.69072348
41CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.65059871
42* REST_18959480_ChIP-ChIP_MESCs_Mouse1.62434539
43* SMAD3_21741376_ChIP-Seq_EPCs_Human1.62240872
44FUS_26573619_Chip-Seq_HEK293_Human1.62157397
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61698184
46DROSHA_22980978_ChIP-Seq_HELA_Human1.59881954
47VDR_22108803_ChIP-Seq_LS180_Human1.58660813
48IKZF1_21737484_ChIP-ChIP_HCT116_Human1.55163989
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.54640694
50* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.53066412
51IGF1R_20145208_ChIP-Seq_DFB_Human1.51723226
52OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49600991
53* PIAS1_25552417_ChIP-Seq_VCAP_Human1.46231251
54KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.44520326
55* SOX9_26525672_Chip-Seq_HEART_Mouse1.43182516
56SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39040435
57SMAD_19615063_ChIP-ChIP_OVARY_Human1.37676690
58RARB_27405468_Chip-Seq_BRAIN_Mouse1.36144687
59MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.35326351
60TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.34251049
61ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.33567573
62* ER_23166858_ChIP-Seq_MCF-7_Human1.33562353
63UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32155660
64E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.31232554
65* AR_25329375_ChIP-Seq_VCAP_Human1.30245883
66CDX2_19796622_ChIP-Seq_MESCs_Mouse1.27951384
67TP53_18474530_ChIP-ChIP_U2OS_Human1.26840767
68CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.26523176
69ZNF274_21170338_ChIP-Seq_K562_Hela1.26197183
70TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.24489590
71* NANOG_18555785_Chip-Seq_ESCs_Mouse1.22727176
72* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.21662940
73* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19918351
74* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.19683658
75* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19316411
76POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19106752
77TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19106752
78* SOX2_21211035_ChIP-Seq_LN229_Gbm1.18796392
79NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.18114521
80RING1B_27294783_Chip-Seq_ESCs_Mouse1.17739807
81* STAT3_23295773_ChIP-Seq_U87_Human1.17595334
82AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17189021
83NR3C1_23031785_ChIP-Seq_PC12_Mouse1.16366629
84EZH2_27294783_Chip-Seq_NPCs_Mouse1.16004853
85STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.15868513
86RUNX2_22187159_ChIP-Seq_PCA_Human1.15054723
87HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.13627104
88IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.13552594
89CBP_20019798_ChIP-Seq_JUKART_Human1.13552594
90TP53_16413492_ChIP-PET_HCT116_Human1.13344677
91FLI1_27457419_Chip-Seq_LIVER_Mouse1.13276630
92* TCF4_23295773_ChIP-Seq_U87_Human1.11989632
93PRDM14_20953172_ChIP-Seq_ESCs_Human1.11882146
94* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11594608
95* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11069830
96* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.10729358
97* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.10651433
98* E2F1_18555785_Chip-Seq_ESCs_Mouse1.10575879
99RING1B_27294783_Chip-Seq_NPCs_Mouse1.09870485
100JUN_21703547_ChIP-Seq_K562_Human1.09869863
101KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08647924
102SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.07827045
103PCGF2_27294783_Chip-Seq_ESCs_Mouse1.07787443
104P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06580147
105ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06001223
106* ARNT_22903824_ChIP-Seq_MCF-7_Human1.05896367
107NRF2_20460467_ChIP-Seq_MEFs_Mouse1.05749191
108NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.05749191
109EP300_21415370_ChIP-Seq_HL-1_Mouse1.05316622
110TRIM28_21343339_ChIP-Seq_HEK293_Human1.04323335
111* P53_22387025_ChIP-Seq_ESCs_Mouse1.03865526
112NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03293258
113* CMYC_18555785_Chip-Seq_ESCs_Mouse1.02338541
114YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98030050
115WT1_19549856_ChIP-ChIP_CCG9911_Human0.97330483
116AR_19668381_ChIP-Seq_PC3_Human0.97137888
117ERG_21242973_ChIP-ChIP_JURKAT_Human0.97123824
118EWS_26573619_Chip-Seq_HEK293_Human0.96906876
119* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.96412651
120AHR_22903824_ChIP-Seq_MCF-7_Human0.96004801
121* CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.95907831
122MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95158850
123POU5F1_16153702_ChIP-ChIP_HESCs_Human0.94654188
124SUZ12_27294783_Chip-Seq_NPCs_Mouse0.94566403
125* BCAT_22108803_ChIP-Seq_LS180_Human0.93600977

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.05535016
2MP0004859_abnormal_synaptic_plasticity4.53573428
3MP0003635_abnormal_synaptic_transmissio3.47855046
4MP0004270_analgesia3.15415512
5MP0001968_abnormal_touch/_nociception3.11343981
6MP0009745_abnormal_behavioral_response3.06505527
7MP0002063_abnormal_learning/memory/cond2.92151563
8MP0009046_muscle_twitch2.82410801
9MP0002736_abnormal_nociception_after2.81188523
10MP0002064_seizures2.69649687
11MP0002572_abnormal_emotion/affect_behav2.66899643
12MP0001486_abnormal_startle_reflex2.55679763
13MP0005423_abnormal_somatic_nervous2.52529090
14MP0002734_abnormal_mechanical_nocicepti2.46542471
15MP0000778_abnormal_nervous_system2.42945694
16MP0002735_abnormal_chemical_nociception2.40184520
17MP0006276_abnormal_autonomic_nervous2.19222945
18MP0002272_abnormal_nervous_system2.17357931
19MP0001440_abnormal_grooming_behavior2.16849989
20MP0001188_hyperpigmentation2.12603856
21MP0002102_abnormal_ear_morphology2.03448237
22MP0002067_abnormal_sensory_capabilities1.98859373
23MP0003787_abnormal_imprinting1.96808335
24MP0002733_abnormal_thermal_nociception1.96721269
25MP0003011_delayed_dark_adaptation1.90346031
26MP0002184_abnormal_innervation1.89335016
27MP0005646_abnormal_pituitary_gland1.86798215
28MP0001970_abnormal_pain_threshold1.83118633
29MP0002938_white_spotting1.81747347
30MP0001529_abnormal_vocalization1.79143565
31MP0003646_muscle_fatigue1.79134759
32MP0001501_abnormal_sleep_pattern1.73232013
33MP0002557_abnormal_social/conspecific_i1.73200071
34MP0000372_irregular_coat_pigmentation1.70136962
35MP0006292_abnormal_olfactory_placode1.68089435
36MP0010030_abnormal_orbit_morphology1.66197362
37MP0005645_abnormal_hypothalamus_physiol1.61838519
38MP0001905_abnormal_dopamine_level1.60922745
39MP0001984_abnormal_olfaction1.58948386
40MP0004142_abnormal_muscle_tone1.56346892
41MP0009780_abnormal_chondrocyte_physiolo1.52186135
42MP0003122_maternal_imprinting1.50503742
43MP0005386_behavior/neurological_phenoty1.50354278
44MP0004924_abnormal_behavior1.50354278
45MP0005253_abnormal_eye_physiology1.44776049
46MP0003136_yellow_coat_color1.40662234
47MP0002282_abnormal_trachea_morphology1.39490176
48MP0004742_abnormal_vestibular_system1.37984410
49MP0000955_abnormal_spinal_cord1.37828684
50MP0002638_abnormal_pupillary_reflex1.34761313
51MP0003879_abnormal_hair_cell1.33883784
52MP0002882_abnormal_neuron_morphology1.33529950
53MP0002233_abnormal_nose_morphology1.31033010
54MP0002234_abnormal_pharynx_morphology1.30826214
55MP0004811_abnormal_neuron_physiology1.29485928
56MP0005171_absent_coat_pigmentation1.29233818
57MP0008569_lethality_at_weaning1.28585051
58MP0002066_abnormal_motor_capabilities/c1.27606182
59MP0003755_abnormal_palate_morphology1.27099275
60MP0000631_abnormal_neuroendocrine_gland1.26729294
61MP0002876_abnormal_thyroid_physiology1.26484665
62MP0003937_abnormal_limbs/digits/tail_de1.24727880
63MP0000579_abnormal_nail_morphology1.23544241
64MP0000026_abnormal_inner_ear1.23334575
65MP0004858_abnormal_nervous_system1.22882913
66MP0000749_muscle_degeneration1.21853047
67MP0000534_abnormal_ureter_morphology1.21382918
68MP0001502_abnormal_circadian_rhythm1.20794187
69MP0002653_abnormal_ependyma_morphology1.17813959
70MP0005409_darkened_coat_color1.16801673
71MP0001963_abnormal_hearing_physiology1.16155829
72MP0002152_abnormal_brain_morphology1.09859516
73MP0000516_abnormal_urinary_system1.07639913
74MP0005367_renal/urinary_system_phenotyp1.07639913
75MP0001293_anophthalmia1.07028957
76MP0002751_abnormal_autonomic_nervous1.06230893
77MP0006072_abnormal_retinal_apoptosis1.05952702
78MP0005187_abnormal_penis_morphology1.05834380
79MP0010386_abnormal_urinary_bladder1.04190891
80MP0002822_catalepsy1.03691388
81MP0004885_abnormal_endolymph1.03360843
82MP0001485_abnormal_pinna_reflex1.02331519
83MP0002752_abnormal_somatic_nervous1.01843163
84MP0001299_abnormal_eye_distance/1.01611111
85MP0005391_vision/eye_phenotype1.01486706
86MP0003938_abnormal_ear_development1.00425023
87MP0001324_abnormal_eye_pigmentation0.97752696
88MP0002090_abnormal_vision0.97465530
89MP0005551_abnormal_eye_electrophysiolog0.94879187
90MP0000537_abnormal_urethra_morphology0.94654635
91MP0000569_abnormal_digit_pigmentation0.90890888
92MP0003890_abnormal_embryonic-extraembry0.89917113
93MP0001664_abnormal_digestion0.89653721
94MP0004133_heterotaxia0.88828618
95MP0005195_abnormal_posterior_eye0.88789882
96MP0003942_abnormal_urinary_system0.88346963
97MP0003329_amyloid_beta_deposits0.87570178
98MP0005623_abnormal_meninges_morphology0.86915043
99MP0002095_abnormal_skin_pigmentation0.86824081
100MP0005394_taste/olfaction_phenotype0.85316146
101MP0005499_abnormal_olfactory_system0.85316146
102MP0004145_abnormal_muscle_electrophysio0.85173149
103MP0000751_myopathy0.85092235
104MP0004085_abnormal_heartbeat0.82634477
105MP0000049_abnormal_middle_ear0.80714814
106MP0009250_abnormal_appendicular_skeleto0.80200443
107MP0002069_abnormal_eating/drinking_beha0.79998292
108MP0003119_abnormal_digestive_system0.79039894
109MP0009384_cardiac_valve_regurgitation0.77938341
110MP0002837_dystrophic_cardiac_calcinosis0.77638535
111MP0002697_abnormal_eye_size0.77077440
112MP0000647_abnormal_sebaceous_gland0.76821142
113MP0009053_abnormal_anal_canal0.75818368
114MP0003861_abnormal_nervous_system0.75027567
115MP0002249_abnormal_larynx_morphology0.75013024
116MP0003633_abnormal_nervous_system0.71749885
117MP0003385_abnormal_body_wall0.71698817
118MP0001986_abnormal_taste_sensitivity0.70833193
119MP0008004_abnormal_stomach_pH0.70551961
120MP0005248_abnormal_Harderian_gland0.70436036
121MP0002909_abnormal_adrenal_gland0.70074862
122MP0003631_nervous_system_phenotype0.70026822
123MP0002229_neurodegeneration0.69973482
124MP0001177_atelectasis0.69350089
125MP0004215_abnormal_myocardial_fiber0.68313327
126MP0009379_abnormal_foot_pigmentation0.68271868
127MP0004134_abnormal_chest_morphology0.67226047
128MP0003121_genomic_imprinting0.66282680
129MP0003137_abnormal_impulse_conducting0.64573911
130MP0003634_abnormal_glial_cell0.63506033
131MP0008789_abnormal_olfactory_epithelium0.63335730
132MP0001943_abnormal_respiration0.62888175
133MP0000566_synostosis0.60231467
134MP0003183_abnormal_peptide_metabolism0.59609963
135MP0004484_altered_response_of0.59275176
136MP0000015_abnormal_ear_pigmentation0.57127557
137MP0010770_preweaning_lethality0.56536566

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.39876038
2Epileptic encephalopathy (HP:0200134)5.02233396
3Atonic seizures (HP:0010819)4.79979549
4Focal seizures (HP:0007359)4.66611501
5Myokymia (HP:0002411)4.47875939
6Febrile seizures (HP:0002373)4.42366728
7Hyperventilation (HP:0002883)4.39320253
8Progressive cerebellar ataxia (HP:0002073)3.59394409
9Absence seizures (HP:0002121)3.52999429
10Broad-based gait (HP:0002136)3.47617169
11Generalized tonic-clonic seizures (HP:0002069)3.41194391
12Dialeptic seizures (HP:0011146)3.31582418
13Abnormality of the labia minora (HP:0012880)3.22358319
14Visual hallucinations (HP:0002367)3.13824293
15Absent/shortened dynein arms (HP:0200106)3.13727300
16Dynein arm defect of respiratory motile cilia (HP:0012255)3.13727300
17Limb dystonia (HP:0002451)3.04629415
18Split foot (HP:0001839)3.04546160
19Megalencephaly (HP:0001355)3.01729136
20Gait imbalance (HP:0002141)2.92877039
21True hermaphroditism (HP:0010459)2.90975967
22Amblyopia (HP:0000646)2.87472785
23Drooling (HP:0002307)2.73986884
24Excessive salivation (HP:0003781)2.73986884
25Polyphagia (HP:0002591)2.70997605
26Abnormal ciliary motility (HP:0012262)2.62786955
27Epileptiform EEG discharges (HP:0011182)2.58635370
28Gaze-evoked nystagmus (HP:0000640)2.53075084
29Inability to walk (HP:0002540)2.51751857
30Medial flaring of the eyebrow (HP:0010747)2.51746318
31Absent speech (HP:0001344)2.50650384
32Protruding tongue (HP:0010808)2.46213240
33Exercise-induced muscle cramps (HP:0003710)2.45433660
34Abnormal eating behavior (HP:0100738)2.44608733
35Abnormal respiratory epithelium morphology (HP:0012253)2.43855249
36Abnormal respiratory motile cilium morphology (HP:0005938)2.43855249
37Abnormal hair whorl (HP:0010721)2.43540922
38Diplopia (HP:0000651)2.43124310
39Abnormality of binocular vision (HP:0011514)2.43124310
40Congenital primary aphakia (HP:0007707)2.41232577
41Hemiparesis (HP:0001269)2.41129216
42Hepatoblastoma (HP:0002884)2.38908656
43Pancreatic fibrosis (HP:0100732)2.38537160
44Postaxial hand polydactyly (HP:0001162)2.34761977
45Nephrogenic diabetes insipidus (HP:0009806)2.30675602
46EEG with generalized epileptiform discharges (HP:0011198)2.29587870
47Insidious onset (HP:0003587)2.26963605
48Termporal pattern (HP:0011008)2.26963605
49Cortical dysplasia (HP:0002539)2.26625806
50Renal hypoplasia (HP:0000089)2.26573685
51Aplasia/Hypoplasia of the tongue (HP:0010295)2.25378348
52Poor eye contact (HP:0000817)2.25271254
53Progressive inability to walk (HP:0002505)2.24880092
54Broad foot (HP:0001769)2.22664686
55Abnormality of the corticospinal tract (HP:0002492)2.22065154
56Blue irides (HP:0000635)2.21985740
57Cutaneous finger syndactyly (HP:0010554)2.19230379
58Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.18482458
59Short 4th metacarpal (HP:0010044)2.18482458
60Dysdiadochokinesis (HP:0002075)2.18259728
61Fetal akinesia sequence (HP:0001989)2.17956816
62Narrow nasal bridge (HP:0000446)2.16829000
63Morphological abnormality of the middle ear (HP:0008609)2.16572134
64Acute necrotizing encephalopathy (HP:0006965)2.15559088
65Muscle fiber inclusion bodies (HP:0100299)2.15063974
66Esotropia (HP:0000565)2.14693523
67Abnormality of midbrain morphology (HP:0002418)2.13825862
68Molar tooth sign on MRI (HP:0002419)2.13825862
69Supranuclear gaze palsy (HP:0000605)2.13466325
70Hypsarrhythmia (HP:0002521)2.12818545
71Retinal dysplasia (HP:0007973)2.11346534
72Specific learning disability (HP:0001328)2.11122649
73Impaired vibration sensation in the lower limbs (HP:0002166)2.10309040
74Action tremor (HP:0002345)2.09471023
75Bifid tongue (HP:0010297)2.06354308
76Abnormality of salivation (HP:0100755)2.05934480
77Long clavicles (HP:0000890)2.05591351
78Colon cancer (HP:0003003)2.03937505
79Facial hemangioma (HP:0000329)2.03326938
80Muscle hypertrophy of the lower extremities (HP:0008968)2.02588023
81Genetic anticipation (HP:0003743)2.00681413
82Mutism (HP:0002300)2.00635942
83Pheochromocytoma (HP:0002666)2.00570766
84Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.99681265
85Degeneration of the lateral corticospinal tracts (HP:0002314)1.99681265
86Short tibia (HP:0005736)1.99677049
87Pancreatic cysts (HP:0001737)1.99664490
88Aplasia/Hypoplasia of the tibia (HP:0005772)1.98702383
89Abnormal respiratory motile cilium physiology (HP:0012261)1.98637100
90Aplasia/Hypoplasia of the lens (HP:0008063)1.98504423
91Genital tract atresia (HP:0001827)1.97283312
92Hyperglycinemia (HP:0002154)1.97043316
93Calf muscle hypertrophy (HP:0008981)1.96748285
94Anxiety (HP:0000739)1.96687883
95Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.96564260
96Nemaline bodies (HP:0003798)1.96166422
97Abnormality of the metopic suture (HP:0005556)1.96034307
98Septo-optic dysplasia (HP:0100842)1.95855634
99Vaginal atresia (HP:0000148)1.94544284
100Ankle clonus (HP:0011448)1.93302746
101White forelock (HP:0002211)1.92552932
102Gastroesophageal reflux (HP:0002020)1.92344196
103Pachygyria (HP:0001302)1.90956211
104Dysmetria (HP:0001310)1.90681612
105Aplasia/Hypoplasia of the sternum (HP:0006714)1.90468877
106Narrow forehead (HP:0000341)1.89898270
107Generalized myoclonic seizures (HP:0002123)1.89644109
108Aplasia cutis congenita (HP:0001057)1.89132022
109Progressive macrocephaly (HP:0004481)1.89130901
110Poor coordination (HP:0002370)1.88981807
111Microglossia (HP:0000171)1.88274626
112Cutaneous syndactyly (HP:0012725)1.87774553
113Abnormality of incisor morphology (HP:0011063)1.87263081
114Sleep apnea (HP:0010535)1.86403367
115Akinesia (HP:0002304)1.86371227
116Preaxial foot polydactyly (HP:0001841)1.86286751
117Intestinal atresia (HP:0011100)1.85927169
118Postaxial foot polydactyly (HP:0001830)1.85891103
119Urinary bladder sphincter dysfunction (HP:0002839)1.84999649
120Abnormal lung lobation (HP:0002101)1.84386496
121Abnormality of glycolysis (HP:0004366)1.84371295
122Increased serum pyruvate (HP:0003542)1.84371295
123Increased corneal curvature (HP:0100692)1.84288582
124Keratoconus (HP:0000563)1.84288582
125Exotropia (HP:0000577)1.84156674
126Type II lissencephaly (HP:0007260)1.83729275
127Vitreoretinal degeneration (HP:0000655)1.83291259
128Sensory axonal neuropathy (HP:0003390)1.82124214
129Aplasia involving bones of the upper limbs (HP:0009823)1.81778943
130Aplasia of the phalanges of the hand (HP:0009802)1.81778943
131Aplasia involving bones of the extremities (HP:0009825)1.81778943
132Type 1 muscle fiber predominance (HP:0003803)1.81777407
133Abnormal mitochondria in muscle tissue (HP:0008316)1.81767628
134Hyperthyroidism (HP:0000836)1.81456787
135Hyperglycinuria (HP:0003108)1.81253176
136Abnormal social behavior (HP:0012433)1.79781625
137Impaired social interactions (HP:0000735)1.79781625
138Abnormality of the calf musculature (HP:0001430)1.79577174
139Preaxial hand polydactyly (HP:0001177)1.79327149
140Truncal ataxia (HP:0002078)1.78837790
141Patchy hypopigmentation of hair (HP:0011365)1.78462782
142Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.76437574
143Astigmatism (HP:0000483)1.76119169
144Neuroendocrine neoplasm (HP:0100634)1.74817465
145Fair hair (HP:0002286)1.74637982
146Optic disc pallor (HP:0000543)1.72621925
147Lissencephaly (HP:0001339)1.72318507
148Aplasia/Hypoplasia of the brainstem (HP:0007362)1.71790440
149Hypoplasia of the brainstem (HP:0002365)1.71790440
150Optic nerve hypoplasia (HP:0000609)1.71529570
151Abnormality of glycine metabolism (HP:0010895)1.70865849
152Abnormality of serine family amino acid metabolism (HP:0010894)1.70865849
153Stereotypic behavior (HP:0000733)1.70802362
154Thickened helices (HP:0000391)1.69998699
155Chorioretinal atrophy (HP:0000533)1.69097433
156Hemiplegia (HP:0002301)1.67969725
157Nephronophthisis (HP:0000090)1.66691285
158Oligodactyly (HP:0012165)1.66058390
159Difficulty running (HP:0009046)1.64483556
160Fibular hypoplasia (HP:0003038)1.61718640
161Decreased testicular size (HP:0008734)1.61656864
162Proximal amyotrophy (HP:0007126)1.57246094
163Sclerocornea (HP:0000647)1.55514065
164Micropenis (HP:0000054)1.54351484
165Absent septum pellucidum (HP:0001331)1.53765032

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.94640844
2MARK14.01431447
3NTRK33.48576781
4EPHA43.06258270
5MAP2K72.99899725
6MAP3K42.62239731
7WEE12.54039078
8NEK12.35797230
9MAPK132.34925389
10NTRK22.26114881
11PLK22.04415475
12MAP3K122.01395974
13TNIK2.00706583
14MINK11.93445602
15EPHA31.91517635
16CDK191.88340197
17OBSCN1.87935684
18MAP4K21.83773130
19PRPF4B1.79214929
20MKNK21.74091568
21NUAK11.68230652
22PINK11.67637253
23DAPK21.58205128
24BRSK21.57602434
25MAP2K41.52291695
26SIK31.47308060
27OXSR11.45178218
28PBK1.43905237
29TRIM281.41946923
30AKT31.37671195
31TAF11.36930547
32MAP3K91.33770130
33BCR1.30974264
34KSR11.29477505
35DYRK21.27078154
36CDK51.24838534
37NME11.23084808
38SIK21.20937924
39CSNK1G11.19226744
40GRK51.18471069
41PHKG21.17905350
42PHKG11.17905350
43PNCK1.16518510
44BLK1.16213988
45PAK61.13932630
46GRK71.12849932
47CAMK2A1.12342146
48DYRK1A1.11236329
49CAMK2B1.08985475
50PRKCG1.07257571
51DAPK11.04924367
52PLK31.01658472
53PLK41.01403504
54CCNB11.00693663
55CSNK1A1L1.00337382
56EPHB20.97946136
57FES0.97708705
58PKN10.97512084
59NEK90.96809629
60BMPR20.95574128
61IRAK20.93724957
62UHMK10.93139061
63MAPK150.92420226
64PRKD30.90551152
65INSRR0.89595982
66VRK10.89038172
67ADRBK20.87865189
68PRKCE0.87301281
69IRAK10.86973076
70BRSK10.86112220
71ERBB30.85671555
72MUSK0.85294597
73WNK30.84458644
74RIPK40.83464877
75FGR0.83411629
76CSNK1G20.82531859
77BCKDK0.77621997
78BMPR1B0.77181673
79DMPK0.76768076
80CDK180.76127212
81SGK4940.75895300
82SGK2230.75895300
83TSSK60.75194659
84STK160.74777732
85CDK140.70308556
86NTRK10.68984329
87CDK150.68100942
88LATS10.67868656
89MAPK120.67162731
90MKNK10.66812545
91MARK20.66748777
92CAMKK20.66563573
93FRK0.66557058
94SGK20.64561564
95ZAK0.64323321
96CDK30.63568812
97LMTK20.63529139
98ADRBK10.61786473
99PTK2B0.61436645
100PLK10.61432468
101PAK30.61264201
102NEK60.60490745
103YES10.59978525
104CDK11A0.59651640
105DYRK1B0.59333978
106DYRK30.57003746
107EIF2AK30.56986411
108PIK3CA0.56508323
109SGK10.55780726
110FER0.55100281
111EIF2AK10.54973667
112CAMK10.51898549
113LIMK10.50528076
114CAMK2D0.49100158
115CAMK1G0.47284473
116STK240.46924405
117STK390.46659743
118FGFR20.45833268
119CSNK1A10.45160459
120TNK20.44605349
121PRKACA0.42794708
122CAMK2G0.42106252
123STK110.41762537
124PRKG10.41627428
125EIF2AK20.41563849
126FYN0.40874305
127TGFBR20.38545424
128CDC42BPA0.37301633
129ROCK20.36872609
130LATS20.36527857
131ERBB20.35914524
132CDK80.35412409
133ERBB40.35249271
134VRK20.34179489
135PRKCZ0.34086645
136PDK40.33971839
137PDK30.33971839
138BRAF0.33493833
139ROCK10.32034018
140CSNK1G30.31843860

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.55222284
2Synaptic vesicle cycle_Homo sapiens_hsa047213.31504100
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.92704848
4GABAergic synapse_Homo sapiens_hsa047272.63003706
5Circadian entrainment_Homo sapiens_hsa047132.60775856
6Morphine addiction_Homo sapiens_hsa050322.59680014
7Glutamatergic synapse_Homo sapiens_hsa047242.56052860
8Collecting duct acid secretion_Homo sapiens_hsa049662.51306264
9Olfactory transduction_Homo sapiens_hsa047402.33185344
10Amphetamine addiction_Homo sapiens_hsa050312.23016141
11Taste transduction_Homo sapiens_hsa047422.16282256
12Serotonergic synapse_Homo sapiens_hsa047262.16015876
13Propanoate metabolism_Homo sapiens_hsa006402.15863561
14Long-term potentiation_Homo sapiens_hsa047202.12952463
15Dopaminergic synapse_Homo sapiens_hsa047282.11324796
16Salivary secretion_Homo sapiens_hsa049702.02824990
17Oxidative phosphorylation_Homo sapiens_hsa001901.94610248
18Axon guidance_Homo sapiens_hsa043601.89614777
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.85769249
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.82657176
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.81904951
22Long-term depression_Homo sapiens_hsa047301.76972196
23Insulin secretion_Homo sapiens_hsa049111.74544570
24Calcium signaling pathway_Homo sapiens_hsa040201.64204423
25Cocaine addiction_Homo sapiens_hsa050301.64087244
26Renin secretion_Homo sapiens_hsa049241.62044712
27Vibrio cholerae infection_Homo sapiens_hsa051101.61486429
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.58456972
29Cholinergic synapse_Homo sapiens_hsa047251.58338625
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.52333069
31Gastric acid secretion_Homo sapiens_hsa049711.48341584
32Oxytocin signaling pathway_Homo sapiens_hsa049211.44213589
33Protein export_Homo sapiens_hsa030601.44114263
34Phototransduction_Homo sapiens_hsa047441.43276822
35Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.39383642
36Alzheimers disease_Homo sapiens_hsa050101.38544364
37Cardiac muscle contraction_Homo sapiens_hsa042601.37177598
38Parkinsons disease_Homo sapiens_hsa050121.34881635
39Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.33605041
40Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.33465012
41Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.30938644
42Aldosterone synthesis and secretion_Homo sapiens_hsa049251.27372917
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.25846011
44Fatty acid metabolism_Homo sapiens_hsa012121.24510321
45Butanoate metabolism_Homo sapiens_hsa006501.23449008
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.23225136
47Hippo signaling pathway_Homo sapiens_hsa043901.22985931
48Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.18948535
49Gap junction_Homo sapiens_hsa045401.16523615
502-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.16345776
51Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.13203683
52cAMP signaling pathway_Homo sapiens_hsa040241.12738417
53Non-homologous end-joining_Homo sapiens_hsa034501.10458099
54Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.07300698
55Nitrogen metabolism_Homo sapiens_hsa009101.06612519
56Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.02552361
57Huntingtons disease_Homo sapiens_hsa050160.99104709
58Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.98392300
59Melanogenesis_Homo sapiens_hsa049160.97667347
60Rheumatoid arthritis_Homo sapiens_hsa053230.96820561
61ErbB signaling pathway_Homo sapiens_hsa040120.93117195
62GnRH signaling pathway_Homo sapiens_hsa049120.91994218
63Basal transcription factors_Homo sapiens_hsa030220.89936203
64cGMP-PKG signaling pathway_Homo sapiens_hsa040220.88924467
65TGF-beta signaling pathway_Homo sapiens_hsa043500.86816294
66Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.83010126
67Vascular smooth muscle contraction_Homo sapiens_hsa042700.82919319
68Fanconi anemia pathway_Homo sapiens_hsa034600.82786713
69Homologous recombination_Homo sapiens_hsa034400.76139717
70Dilated cardiomyopathy_Homo sapiens_hsa054140.75634652
71Arginine and proline metabolism_Homo sapiens_hsa003300.75209567
72Ras signaling pathway_Homo sapiens_hsa040140.74829454
73Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.72462944
74Wnt signaling pathway_Homo sapiens_hsa043100.70952090
75Estrogen signaling pathway_Homo sapiens_hsa049150.70722166
76Cysteine and methionine metabolism_Homo sapiens_hsa002700.69690401
77Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69067453
78Phagosome_Homo sapiens_hsa041450.68923185
79Tight junction_Homo sapiens_hsa045300.68701761
80Type II diabetes mellitus_Homo sapiens_hsa049300.68223467
81Fatty acid degradation_Homo sapiens_hsa000710.67527972
82Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.67301276
83MAPK signaling pathway_Homo sapiens_hsa040100.65909896
84Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.65634177
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65475280
86Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65259045
87Circadian rhythm_Homo sapiens_hsa047100.63144900
88Adherens junction_Homo sapiens_hsa045200.62823268
89Pyruvate metabolism_Homo sapiens_hsa006200.60294749
90Pancreatic secretion_Homo sapiens_hsa049720.60255667
91Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59158074
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58477169
93Peroxisome_Homo sapiens_hsa041460.57567702
94beta-Alanine metabolism_Homo sapiens_hsa004100.56362846
95Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.56106166
96Melanoma_Homo sapiens_hsa052180.52306753
97Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.52008525
98Lysine degradation_Homo sapiens_hsa003100.51627118
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50506187
100Rap1 signaling pathway_Homo sapiens_hsa040150.50162802
101Steroid biosynthesis_Homo sapiens_hsa001000.48569123
102Glioma_Homo sapiens_hsa052140.47972363
103Carbon metabolism_Homo sapiens_hsa012000.47860914
104Vitamin B6 metabolism_Homo sapiens_hsa007500.45896840
105AMPK signaling pathway_Homo sapiens_hsa041520.44939306
106Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.44586721
107Phospholipase D signaling pathway_Homo sapiens_hsa040720.44521103
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44148186
109PPAR signaling pathway_Homo sapiens_hsa033200.43665528
110RNA degradation_Homo sapiens_hsa030180.43342740
111African trypanosomiasis_Homo sapiens_hsa051430.41939404
112Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41675255
113Base excision repair_Homo sapiens_hsa034100.41367315
114Choline metabolism in cancer_Homo sapiens_hsa052310.41331701
115Fatty acid biosynthesis_Homo sapiens_hsa000610.41250689
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40100928
117Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.39829272
118Ovarian steroidogenesis_Homo sapiens_hsa049130.39779354
119Biosynthesis of amino acids_Homo sapiens_hsa012300.38594860
120Hedgehog signaling pathway_Homo sapiens_hsa043400.37338182
121Type I diabetes mellitus_Homo sapiens_hsa049400.36822531
122Alcoholism_Homo sapiens_hsa050340.35578368
123Thyroid hormone synthesis_Homo sapiens_hsa049180.34390316
124Sphingolipid signaling pathway_Homo sapiens_hsa040710.33355251
125Fatty acid elongation_Homo sapiens_hsa000620.32492121
126Glucagon signaling pathway_Homo sapiens_hsa049220.32207436
127Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.28634144
128Ether lipid metabolism_Homo sapiens_hsa005650.28473361
129Oocyte meiosis_Homo sapiens_hsa041140.27075729
130Regulation of actin cytoskeleton_Homo sapiens_hsa048100.26902970
131Dorso-ventral axis formation_Homo sapiens_hsa043200.26216705
132Regulation of autophagy_Homo sapiens_hsa041400.25455683
133Renal cell carcinoma_Homo sapiens_hsa052110.24740539
134Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.24476565
135Basal cell carcinoma_Homo sapiens_hsa052170.24187766
136Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.23700279
137Inositol phosphate metabolism_Homo sapiens_hsa005620.22663563
138Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.21060751

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