DOK6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: DOK6 is a member of the DOK (see DOK1; MIM 602919) family of intracellular adaptors that play a role in the RET (MIM 164761) signaling cascade (Crowder et al., 2004 [PubMed 15286081]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ionotropic glutamate receptor signaling pathway (GO:0035235)5.57849439
2auditory behavior (GO:0031223)5.36442690
3regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.22407617
4neuron cell-cell adhesion (GO:0007158)5.16629281
5vocalization behavior (GO:0071625)5.04926049
6regulation of short-term neuronal synaptic plasticity (GO:0048172)5.02076232
7glutamate receptor signaling pathway (GO:0007215)4.94058248
8response to auditory stimulus (GO:0010996)4.76483957
9synaptic transmission, glutamatergic (GO:0035249)4.71575003
10regulation of glutamate receptor signaling pathway (GO:1900449)4.65589526
11startle response (GO:0001964)4.64534649
12positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.53342424
13mechanosensory behavior (GO:0007638)4.38921396
14neuron recognition (GO:0008038)4.13380593
15locomotory exploration behavior (GO:0035641)4.10647207
16protein localization to synapse (GO:0035418)4.04767978
17axonal fasciculation (GO:0007413)4.00646479
18neurotransmitter-gated ion channel clustering (GO:0072578)3.93862122
19neuron-neuron synaptic transmission (GO:0007270)3.91609442
20G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.87875298
21regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.83199571
22postsynaptic membrane organization (GO:0001941)3.82983097
23innervation (GO:0060384)3.82684490
24cellular potassium ion homeostasis (GO:0030007)3.81566231
25central nervous system projection neuron axonogenesis (GO:0021952)3.79087789
26glutamate secretion (GO:0014047)3.67238580
27negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.66996257
28synaptic vesicle endocytosis (GO:0048488)3.64220643
29regulation of synapse structural plasticity (GO:0051823)3.60821633
30regulation of synaptic transmission, glutamatergic (GO:0051966)3.59508469
31G-protein coupled receptor internalization (GO:0002031)3.58248598
32positive regulation of dendritic spine development (GO:0060999)3.57422179
33membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.56383329
34regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.55781675
35exploration behavior (GO:0035640)3.52064667
36L-amino acid import (GO:0043092)3.51364724
37regulation of long-term neuronal synaptic plasticity (GO:0048169)3.50309525
38serotonin receptor signaling pathway (GO:0007210)3.46583751
39negative regulation of synaptic transmission, GABAergic (GO:0032229)3.44282369
40regulation of dendritic spine morphogenesis (GO:0061001)3.43121743
41neurotransmitter transport (GO:0006836)3.40390080
42sodium ion export (GO:0071436)3.39176058
43cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.38102470
44presynaptic membrane assembly (GO:0097105)3.37591877
45gamma-aminobutyric acid signaling pathway (GO:0007214)3.37167839
46regulation of neuronal synaptic plasticity (GO:0048168)3.35732220
47dendritic spine morphogenesis (GO:0060997)3.32429807
48opioid receptor signaling pathway (GO:0038003)3.31336425
49cell migration in hindbrain (GO:0021535)3.28945480
50synapse assembly (GO:0007416)3.28591853
51regulation of dendritic spine development (GO:0060998)3.27305130
52synaptic vesicle docking involved in exocytosis (GO:0016081)3.25996314
53synaptic vesicle exocytosis (GO:0016079)3.25762297
54neuronal action potential propagation (GO:0019227)3.25689976
55pyrimidine nucleobase catabolic process (GO:0006208)3.25539849
56synaptic vesicle maturation (GO:0016188)3.24792768
57regulation of synapse maturation (GO:0090128)3.21415029
58positive regulation of neurotransmitter secretion (GO:0001956)3.21369480
59proline transport (GO:0015824)3.20354093
60righting reflex (GO:0060013)3.19569782
61regulation of neurotransmitter transport (GO:0051588)3.18120077
62cochlea development (GO:0090102)3.16919151
63regulation of excitatory postsynaptic membrane potential (GO:0060079)3.16875010
64gamma-aminobutyric acid transport (GO:0015812)3.14860898
65regulation of neurotransmitter levels (GO:0001505)3.12496577
66regulation of voltage-gated calcium channel activity (GO:1901385)3.12458187
67atrial cardiac muscle cell action potential (GO:0086014)3.12038731
68negative regulation of dendrite development (GO:2000171)3.12008369
69cellular sodium ion homeostasis (GO:0006883)3.11875109
70regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.09313236
71regulation of postsynaptic membrane potential (GO:0060078)3.08716226
72amino acid import (GO:0043090)3.08267387
73neurotransmitter secretion (GO:0007269)3.06532764
74transmission of nerve impulse (GO:0019226)3.05782372
75behavioral fear response (GO:0001662)3.01645542
76behavioral defense response (GO:0002209)3.01645542
77cerebral cortex radially oriented cell migration (GO:0021799)3.01329698
78prepulse inhibition (GO:0060134)3.01027472
79positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.00812504
80potassium ion import (GO:0010107)2.99194408
81positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.97123579
82positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.97113876
83membrane depolarization during action potential (GO:0086010)2.96888317
84positive regulation of dendritic spine morphogenesis (GO:0061003)2.96634127
85regulation of synaptic vesicle transport (GO:1902803)2.95491070
86positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.94503458
87neuronal action potential (GO:0019228)2.94263110
88positive regulation of synaptic transmission, GABAergic (GO:0032230)2.94135791
89adenine nucleotide transport (GO:0051503)2.93788407
90membrane hyperpolarization (GO:0060081)2.93701771
91cerebellar granule cell differentiation (GO:0021707)2.93369986
92presynaptic membrane organization (GO:0097090)2.92971891
93regulation of vesicle fusion (GO:0031338)2.92601779
94dendrite morphogenesis (GO:0048813)2.92501177
95positive regulation of synapse maturation (GO:0090129)2.92179456
96long-term memory (GO:0007616)2.92020498
97serotonin metabolic process (GO:0042428)2.90886116
98reflex (GO:0060004)2.89916700
99cAMP-mediated signaling (GO:0019933)2.89321069
100positive regulation of neurotransmitter transport (GO:0051590)2.89039821
101regulation of synaptic vesicle exocytosis (GO:2000300)2.88069169
102central nervous system neuron axonogenesis (GO:0021955)2.87883106
103negative regulation of cytosolic calcium ion concentration (GO:0051481)2.87593059
104cerebellum development (GO:0021549)2.86776989
105cell communication by electrical coupling (GO:0010644)2.86678635
106neuromuscular synaptic transmission (GO:0007274)2.85177932
107potassium ion homeostasis (GO:0055075)2.85125063
108axon ensheathment in central nervous system (GO:0032291)2.84762563
109central nervous system myelination (GO:0022010)2.84762563
110adult walking behavior (GO:0007628)2.84488808
111synaptic transmission (GO:0007268)2.83907859
112negative regulation of neurotransmitter transport (GO:0051589)2.83875962
113retinal ganglion cell axon guidance (GO:0031290)2.83252112
114regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.83143620
115regulation of synapse assembly (GO:0051963)2.82691100
116positive regulation of synapse assembly (GO:0051965)2.82603374
117regulation of synaptic transmission, GABAergic (GO:0032228)2.81322167
118positive regulation of membrane potential (GO:0045838)2.79468765
119membrane depolarization (GO:0051899)2.77422515
120layer formation in cerebral cortex (GO:0021819)2.76243454
121auditory receptor cell stereocilium organization (GO:0060088)2.73559444
122dendritic spine organization (GO:0097061)2.73499561
123regulation of synapse organization (GO:0050807)2.72692335
124learning (GO:0007612)2.72307602
125cerebellar Purkinje cell differentiation (GO:0021702)2.68713772
126calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.68248087
127regulation of neurotransmitter secretion (GO:0046928)2.68019193
128regulation of synaptic plasticity (GO:0048167)2.67970639
129neuronal ion channel clustering (GO:0045161)2.67362724

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.66627671
2GBX2_23144817_ChIP-Seq_PC3_Human4.49925057
3JARID2_20064375_ChIP-Seq_MESCs_Mouse2.79201303
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.76668810
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.69283491
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.52187133
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.48381451
8SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.44318014
9EED_16625203_ChIP-ChIP_MESCs_Mouse2.33466891
10* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.33412484
11* EZH2_27304074_Chip-Seq_ESCs_Mouse2.30121005
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.24893006
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.24893006
14* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.22954240
15ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.20270891
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.11898016
17REST_21632747_ChIP-Seq_MESCs_Mouse2.06919668
18* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.05391714
19RNF2_27304074_Chip-Seq_ESCs_Mouse2.02143599
20* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.00444256
21DROSHA_22980978_ChIP-Seq_HELA_Human1.98383751
22IGF1R_20145208_ChIP-Seq_DFB_Human1.97639767
23CTBP2_25329375_ChIP-Seq_LNCAP_Human1.97521390
24* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.97248354
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.93724744
26* EZH2_27294783_Chip-Seq_ESCs_Mouse1.91084551
27P300_19829295_ChIP-Seq_ESCs_Human1.89767199
28SUZ12_27294783_Chip-Seq_ESCs_Mouse1.86083947
29CBX2_27304074_Chip-Seq_ESCs_Mouse1.84993955
30TAF15_26573619_Chip-Seq_HEK293_Human1.83475218
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.81908211
32PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.81799751
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.80453768
34CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.78451767
35SMAD4_21799915_ChIP-Seq_A2780_Human1.76181465
36IKZF1_21737484_ChIP-ChIP_HCT116_Human1.75219704
37BMI1_23680149_ChIP-Seq_NPCS_Mouse1.73280298
38AR_21572438_ChIP-Seq_LNCaP_Human1.65196462
39POU3F2_20337985_ChIP-ChIP_501MEL_Human1.62122812
40PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.56802835
41RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.56681606
42VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.55544131
43PIAS1_25552417_ChIP-Seq_VCAP_Human1.53929239
44RNF2_27304074_Chip-Seq_NSC_Mouse1.46936562
45TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.45703075
46CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.45482978
47FUS_26573619_Chip-Seq_HEK293_Human1.45008558
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.43867428
49AR_25329375_ChIP-Seq_VCAP_Human1.42966628
50STAT3_23295773_ChIP-Seq_U87_Human1.41028533
51NANOG_18555785_Chip-Seq_ESCs_Mouse1.39235677
52PCGF2_27294783_Chip-Seq_ESCs_Mouse1.38912076
53HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.38302629
54REST_18959480_ChIP-ChIP_MESCs_Mouse1.36432418
55TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36232254
56POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.36232254
57VDR_22108803_ChIP-Seq_LS180_Human1.35492395
58* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34641372
59TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33817504
60SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33112643
61E2F1_18555785_Chip-Seq_ESCs_Mouse1.32624623
62EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.32117409
63AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.30747558
64NR3C1_23031785_ChIP-Seq_PC12_Mouse1.30622227
65SUZ12_27294783_Chip-Seq_NPCs_Mouse1.30257903
66BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.29368764
67TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28572892
68TP53_18474530_ChIP-ChIP_U2OS_Human1.28289353
69FLI1_27457419_Chip-Seq_LIVER_Mouse1.27023963
70* ARNT_22903824_ChIP-Seq_MCF-7_Human1.26797779
71TCF4_23295773_ChIP-Seq_U87_Human1.25903714
72RARB_27405468_Chip-Seq_BRAIN_Mouse1.24716117
73CMYC_18555785_Chip-Seq_ESCs_Mouse1.24164637
74SOX2_21211035_ChIP-Seq_LN229_Gbm1.23989712
75CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23434363
76P53_22387025_ChIP-Seq_ESCs_Mouse1.23229330
77CDX2_19796622_ChIP-Seq_MESCs_Mouse1.22600003
78ER_23166858_ChIP-Seq_MCF-7_Human1.22223250
79NFE2_27457419_Chip-Seq_LIVER_Mouse1.21456551
80TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21240347
81AHR_22903824_ChIP-Seq_MCF-7_Human1.20727617
82RUNX2_22187159_ChIP-Seq_PCA_Human1.20222623
83SMAD_19615063_ChIP-ChIP_OVARY_Human1.19428145
84UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18622424
85NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17495560
86EWS_26573619_Chip-Seq_HEK293_Human1.17012480
87ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16677042
88SUZ12_18555785_Chip-Seq_ESCs_Mouse1.16165931
89NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.15869197
90LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14875028
91* AR_19668381_ChIP-Seq_PC3_Human1.14579924
92PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.14092276
93TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.13275663
94RING1B_27294783_Chip-Seq_ESCs_Mouse1.13150804
95WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12640790
96JUN_21703547_ChIP-Seq_K562_Human1.12164015
97EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.11327741
98STAT3_18555785_Chip-Seq_ESCs_Mouse1.10413427
99CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.10098897
100PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08533699
101MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08411971
102KDM2B_26808549_Chip-Seq_REH_Human1.08105511
103YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07149280
104RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.06675999
105BCAT_22108803_ChIP-Seq_LS180_Human1.06469365
106PRDM14_20953172_ChIP-Seq_ESCs_Human1.05872882
107KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.05806281
108NMYC_18555785_Chip-Seq_ESCs_Mouse1.05739801
109SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05704309
110EZH2_27294783_Chip-Seq_NPCs_Mouse1.05698209
111TP53_16413492_ChIP-PET_HCT116_Human1.05454127
112RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.05399798
113SOX2_18555785_Chip-Seq_ESCs_Mouse1.05362356
114* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04619455
115FLI1_21867929_ChIP-Seq_TH2_Mouse1.02514807
116RING1B_27294783_Chip-Seq_NPCs_Mouse1.01147766
117P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01033394
118SMAD4_21741376_ChIP-Seq_HESCs_Human0.99828271
119TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.99361509
120SMAD3_21741376_ChIP-Seq_HESCs_Human0.96608128
121* SOX9_26525672_Chip-Seq_HEART_Mouse0.96110302

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.77428980
2MP0003880_abnormal_central_pattern3.61471891
3MP0003635_abnormal_synaptic_transmissio3.55100085
4MP0009745_abnormal_behavioral_response3.23557232
5MP0001968_abnormal_touch/_nociception3.17852301
6MP0002063_abnormal_learning/memory/cond3.14009745
7MP0002736_abnormal_nociception_after3.02432488
8MP0002735_abnormal_chemical_nociception2.94245985
9MP0001486_abnormal_startle_reflex2.82587471
10MP0002572_abnormal_emotion/affect_behav2.80987960
11MP0006292_abnormal_olfactory_placode2.69876108
12MP0002064_seizures2.56710469
13MP0005645_abnormal_hypothalamus_physiol2.53704796
14MP0000778_abnormal_nervous_system2.36908393
15MP0004270_analgesia2.29906053
16MP0002638_abnormal_pupillary_reflex2.18766805
17MP0009046_muscle_twitch2.18194617
18MP0005646_abnormal_pituitary_gland2.17881506
19MP0002272_abnormal_nervous_system2.17810274
20MP0001440_abnormal_grooming_behavior2.17128988
21MP0001188_hyperpigmentation2.10826646
22MP0002102_abnormal_ear_morphology2.09342856
23MP0002734_abnormal_mechanical_nocicepti2.05629784
24MP0001501_abnormal_sleep_pattern2.02616595
25MP0002184_abnormal_innervation1.98342026
26MP0002557_abnormal_social/conspecific_i1.98177548
27MP0000566_synostosis1.97924673
28MP0002067_abnormal_sensory_capabilities1.95877709
29MP0001984_abnormal_olfaction1.93004571
30MP0002822_catalepsy1.88280593
31MP0006276_abnormal_autonomic_nervous1.78971552
32MP0001502_abnormal_circadian_rhythm1.78869593
33MP0005423_abnormal_somatic_nervous1.73721493
34MP0010386_abnormal_urinary_bladder1.66059267
35MP0001970_abnormal_pain_threshold1.65388077
36MP0002733_abnormal_thermal_nociception1.63011294
37MP0003787_abnormal_imprinting1.61144125
38MP0004742_abnormal_vestibular_system1.53271845
39MP0004858_abnormal_nervous_system1.51032757
40MP0001529_abnormal_vocalization1.48173383
41MP0000955_abnormal_spinal_cord1.44711280
42MP0003136_yellow_coat_color1.44239155
43MP0000569_abnormal_digit_pigmentation1.43528708
44MP0004924_abnormal_behavior1.42324939
45MP0005386_behavior/neurological_phenoty1.42324939
46MP0009780_abnormal_chondrocyte_physiolo1.41750975
47MP0004885_abnormal_endolymph1.35199446
48MP0004811_abnormal_neuron_physiology1.35151993
49MP0004142_abnormal_muscle_tone1.34818600
50MP0000631_abnormal_neuroendocrine_gland1.31055588
51MP0001963_abnormal_hearing_physiology1.27673259
52MP0002882_abnormal_neuron_morphology1.25665160
53MP0001177_atelectasis1.25420391
54MP0003329_amyloid_beta_deposits1.25022758
55MP0000026_abnormal_inner_ear1.24913991
56MP0003879_abnormal_hair_cell1.24119065
57MP0001905_abnormal_dopamine_level1.22569272
58MP0003122_maternal_imprinting1.19988119
59MP0002066_abnormal_motor_capabilities/c1.16788256
60MP0005187_abnormal_penis_morphology1.10906081
61MP0005394_taste/olfaction_phenotype1.09074316
62MP0005499_abnormal_olfactory_system1.09074316
63MP0008569_lethality_at_weaning1.08691160
64MP0001485_abnormal_pinna_reflex1.03248062
65MP0002876_abnormal_thyroid_physiology1.02532625
66MP0002152_abnormal_brain_morphology1.02467856
67MP0002229_neurodegeneration1.00525788
68MP0005551_abnormal_eye_electrophysiolog1.00316436
69MP0000920_abnormal_myelination0.98164252
70MP0001986_abnormal_taste_sensitivity0.96717820
71MP0000516_abnormal_urinary_system0.96123738
72MP0005367_renal/urinary_system_phenotyp0.96123738
73MP0003632_abnormal_nervous_system0.96071331
74MP0003690_abnormal_glial_cell0.95979843
75MP0002752_abnormal_somatic_nervous0.95844658
76MP0002938_white_spotting0.95837278
77MP0005171_absent_coat_pigmentation0.95487710
78MP0008872_abnormal_physiological_respon0.93597718
79MP0003938_abnormal_ear_development0.88383109
80MP0000015_abnormal_ear_pigmentation0.87247766
81MP0008789_abnormal_olfactory_epithelium0.87134086
82MP0000579_abnormal_nail_morphology0.86013980
83MP0000538_abnormal_urinary_bladder0.85102490
84MP0004215_abnormal_myocardial_fiber0.82255724
85MP0003137_abnormal_impulse_conducting0.81661264
86MP0003633_abnormal_nervous_system0.81150802
87MP0003283_abnormal_digestive_organ0.80729658
88MP0002751_abnormal_autonomic_nervous0.79312765
89MP0002069_abnormal_eating/drinking_beha0.76286381
90MP0002909_abnormal_adrenal_gland0.74600894
91MP0005409_darkened_coat_color0.74148168
92MP0003941_abnormal_skin_development0.74109196
93MP0000534_abnormal_ureter_morphology0.73569382
94MP0005253_abnormal_eye_physiology0.72673796
95MP0004085_abnormal_heartbeat0.72170401
96MP0005257_abnormal_intraocular_pressure0.71346137
97MP0003861_abnormal_nervous_system0.70549657
98MP0003631_nervous_system_phenotype0.69641744
99MP0003121_genomic_imprinting0.68761631
100MP0005248_abnormal_Harderian_gland0.67220489
101MP0003890_abnormal_embryonic-extraembry0.63904508
102MP0001299_abnormal_eye_distance/0.62764542
103MP0010769_abnormal_survival0.62375592
104MP0001943_abnormal_respiration0.61334272
105MP0002177_abnormal_outer_ear0.60968913
106MP0004147_increased_porphyrin_level0.60539712
107MP0003123_paternal_imprinting0.59815691
108MP0002234_abnormal_pharynx_morphology0.59091123
109MP0010768_mortality/aging0.58680047
110MP0002277_abnormal_respiratory_mucosa0.58395964
111MP0004145_abnormal_muscle_electrophysio0.57386637
112MP0005174_abnormal_tail_pigmentation0.56499948
113MP0004130_abnormal_muscle_cell0.55905338
114MP0002089_abnormal_postnatal_growth/wei0.55732776
115MP0010770_preweaning_lethality0.55318828
116MP0002082_postnatal_lethality0.55318828
117MP0004133_heterotaxia0.54368357
118MP0008874_decreased_physiological_sensi0.54063039
119MP0002081_perinatal_lethality0.53628497
120MP0005167_abnormal_blood-brain_barrier0.52973172
121MP0008877_abnormal_DNA_methylation0.52763920
122MP0001664_abnormal_digestion0.52745971
123MP0003634_abnormal_glial_cell0.51868238
124MP0005670_abnormal_white_adipose0.51856228
125MP0000639_abnormal_adrenal_gland0.50529712

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.58940843
2Febrile seizures (HP:0002373)5.66339903
3Epileptic encephalopathy (HP:0200134)4.13625022
4Focal seizures (HP:0007359)4.02689205
5Myokymia (HP:0002411)3.91246123
6Hyperventilation (HP:0002883)3.65624116
7Diplopia (HP:0000651)3.60952115
8Abnormality of binocular vision (HP:0011514)3.60952115
9Chromosomal breakage induced by crosslinking agents (HP:0003221)3.31177888
10Fair hair (HP:0002286)3.24256655
11Broad-based gait (HP:0002136)3.23339890
12Atonic seizures (HP:0010819)3.20911283
13Papilledema (HP:0001085)3.17997681
14Long nose (HP:0003189)3.15529395
15Generalized tonic-clonic seizures (HP:0002069)3.10214452
16Urinary bladder sphincter dysfunction (HP:0002839)2.99085174
17Spastic gait (HP:0002064)2.96480134
18Megalencephaly (HP:0001355)2.90870144
19Drooling (HP:0002307)2.87465796
20Excessive salivation (HP:0003781)2.87465796
21Abnormality of the corticospinal tract (HP:0002492)2.85673529
22Ankle clonus (HP:0011448)2.84969485
23Septo-optic dysplasia (HP:0100842)2.84149400
24Generalized hypopigmentation of hair (HP:0011358)2.74562744
25Blue irides (HP:0000635)2.74345426
26Absent speech (HP:0001344)2.71565255
27Progressive cerebellar ataxia (HP:0002073)2.69487023
28Urinary urgency (HP:0000012)2.67032849
29Protruding tongue (HP:0010808)2.63925184
30Hypsarrhythmia (HP:0002521)2.63108358
31Hemiplegia (HP:0002301)2.61570849
32Mutism (HP:0002300)2.60955282
33Torticollis (HP:0000473)2.60677882
34Retrobulbar optic neuritis (HP:0100654)2.58121883
35Optic neuritis (HP:0100653)2.58121883
36Akinesia (HP:0002304)2.57378164
37Dynein arm defect of respiratory motile cilia (HP:0012255)2.57305490
38Absent/shortened dynein arms (HP:0200106)2.57305490
39Hemiparesis (HP:0001269)2.54999408
40Chronic hepatic failure (HP:0100626)2.54612373
41Chromsome breakage (HP:0040012)2.49950700
42Absence seizures (HP:0002121)2.49548864
43Neurofibrillary tangles (HP:0002185)2.45403859
44Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.43152259
45Degeneration of the lateral corticospinal tracts (HP:0002314)2.43152259
46Fetal akinesia sequence (HP:0001989)2.40434198
47Status epilepticus (HP:0002133)2.36747251
48Poor eye contact (HP:0000817)2.36138127
49Dialeptic seizures (HP:0011146)2.33730920
50Genetic anticipation (HP:0003743)2.30102315
51Abnormality of salivation (HP:0100755)2.24145065
52Lower limb muscle weakness (HP:0007340)2.23716782
53Tubulointerstitial nephritis (HP:0001970)2.22747094
54Pheochromocytoma (HP:0002666)2.19804488
55Gastroesophageal reflux (HP:0002020)2.18773355
56Abnormal hair whorl (HP:0010721)2.17264016
57Morphological abnormality of the pyramidal tract (HP:0002062)2.12551098
58Aqueductal stenosis (HP:0002410)2.11689197
59Deeply set eye (HP:0000490)2.08848716
60Lissencephaly (HP:0001339)2.06938723
61Dysmetria (HP:0001310)2.06585302
62Gaze-evoked nystagmus (HP:0000640)2.02804186
63Visual hallucinations (HP:0002367)2.02213811
64Delusions (HP:0000746)2.00564316
65Postural instability (HP:0002172)1.98062219
66Shawl scrotum (HP:0000049)1.97820256
67Intention tremor (HP:0002080)1.96526164
68Oligodactyly (hands) (HP:0001180)1.95863456
69Cerebral inclusion bodies (HP:0100314)1.94726275
70Focal dystonia (HP:0004373)1.93991845
71Nephronophthisis (HP:0000090)1.93792967
72Abnormal social behavior (HP:0012433)1.92353673
73Impaired social interactions (HP:0000735)1.92353673
74Anxiety (HP:0000739)1.91924600
75Amyotrophic lateral sclerosis (HP:0007354)1.91720400
76Aplasia cutis congenita (HP:0001057)1.90502529
77Absent septum pellucidum (HP:0001331)1.89270809
78Impaired vibratory sensation (HP:0002495)1.89244084
79Impaired vibration sensation in the lower limbs (HP:0002166)1.89162079
80Neuroendocrine neoplasm (HP:0100634)1.88967390
81Thyroid-stimulating hormone excess (HP:0002925)1.87236736
82Abnormal ciliary motility (HP:0012262)1.86561477
83Abnormality of the renal medulla (HP:0100957)1.85960280
84Autism (HP:0000717)1.85957272
85Dry hair (HP:0011359)1.84330566
86Amblyopia (HP:0000646)1.83855304
87Sleep apnea (HP:0010535)1.83822342
88Volvulus (HP:0002580)1.83236083
89True hermaphroditism (HP:0010459)1.83150019
90Supranuclear gaze palsy (HP:0000605)1.83055348
91Spastic tetraplegia (HP:0002510)1.83048261
92Cerebral hypomyelination (HP:0006808)1.82972628
93Cutaneous finger syndactyly (HP:0010554)1.82885359
94Truncal ataxia (HP:0002078)1.82845460
95Bradykinesia (HP:0002067)1.82800636
96Abnormal EKG (HP:0003115)1.80324723
97Action tremor (HP:0002345)1.80308209
98Epileptiform EEG discharges (HP:0011182)1.79641962
99Scrotal hypoplasia (HP:0000046)1.79437291
100Abnormality of the lower motor neuron (HP:0002366)1.78876957
101Abnormality of the labia minora (HP:0012880)1.78487149
102Prolonged QT interval (HP:0001657)1.78103374
103Cutaneous syndactyly (HP:0012725)1.78024119
104Widely spaced teeth (HP:0000687)1.77996210
105Optic nerve hypoplasia (HP:0000609)1.77763308
106Hip dysplasia (HP:0001385)1.77654225
107Craniofacial dystonia (HP:0012179)1.77596814
108Aplasia involving bones of the upper limbs (HP:0009823)1.77016003
109Aplasia of the phalanges of the hand (HP:0009802)1.77016003
110Aplasia involving bones of the extremities (HP:0009825)1.77016003
111Bile duct proliferation (HP:0001408)1.76692001
112Abnormal biliary tract physiology (HP:0012439)1.76692001
113Decreased central vision (HP:0007663)1.76178785
114Duplication of thumb phalanx (HP:0009942)1.73450880
115Hypoplasia of the corpus callosum (HP:0002079)1.73339054
116Clonus (HP:0002169)1.72924870
117Syncope (HP:0001279)1.72253685
118Abnormality of incisor morphology (HP:0011063)1.72161236
119Decreased circulating renin level (HP:0003351)1.70729697
120Inability to walk (HP:0002540)1.69495375
121Preaxial hand polydactyly (HP:0001177)1.68072719
122Abnormality of the septum pellucidum (HP:0007375)1.67913413
123Pachygyria (HP:0001302)1.67882411
124Abnormality of the columella (HP:0009929)1.67657253
125Scanning speech (HP:0002168)1.67550690
126Intellectual disability, severe (HP:0010864)1.66663320
127Prominent supraorbital ridges (HP:0000336)1.66360789
128Osteomalacia (HP:0002749)1.66030746
129Stereotypic behavior (HP:0000733)1.65305661
130Exotropia (HP:0000577)1.65259523
131Papillary thyroid carcinoma (HP:0002895)1.64752884
132Renal hypoplasia (HP:0000089)1.64255520
133Midline defect of the nose (HP:0004122)1.63523575
134Obstructive sleep apnea (HP:0002870)1.63150783
135Abnormality of the nasal septum (HP:0000419)1.61607231
136Thickened helices (HP:0000391)1.61523843
137Pancreatic fibrosis (HP:0100732)1.61453333
138Agitation (HP:0000713)1.61353037
139Anophthalmia (HP:0000528)1.60404338
140Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.59201051
141Dysdiadochokinesis (HP:0002075)1.58590814
142Incomplete penetrance (HP:0003829)1.58055824
143Limb dystonia (HP:0002451)1.56870614
144Spinal canal stenosis (HP:0003416)1.56828769
145Medial flaring of the eyebrow (HP:0010747)1.56784199
146EEG with generalized epileptiform discharges (HP:0011198)1.56747196
147Abnormal eating behavior (HP:0100738)1.56200188
148Gait imbalance (HP:0002141)1.56023562
149Polyphagia (HP:0002591)1.55863074
150Esotropia (HP:0000565)1.55845076

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.98375613
2EPHA44.09597319
3MARK13.50266100
4CASK3.49561292
5NTRK23.34390098
6TNIK2.77100759
7MAP2K72.76516346
8MAPK132.59497863
9SIK32.38438806
10MAP3K42.31577611
11MAP3K91.83189780
12SIK21.83140815
13RIPK41.80461123
14PRPF4B1.76028173
15ADRBK21.75693384
16PNCK1.72219183
17INSRR1.64328483
18CAMKK21.57296746
19BMPR21.55907914
20EIF2AK21.55415605
21MINK11.54975439
22SGK21.50896756
23KSR11.45908662
24FRK1.38393053
25PRKD31.38226052
26PRKCG1.28640372
27TXK1.25865865
28PLK21.23944298
29DAPK21.17581179
30TYRO31.15176783
31CDK51.09854420
32MAP2K41.07200038
33CDK31.07192828
34SGK4941.02090347
35SGK2231.02090347
36STK161.02031638
37MAP3K120.99736493
38YES10.97845913
39CAMK2A0.95236820
40SGK10.93354734
41STK380.92544360
42SGK30.92125128
43PAK60.90955684
44PINK10.90142226
45PKN10.89748283
46PRKCE0.88266671
47FGFR20.86710020
48TNK20.86559887
49CCNB10.83276494
50NEK60.83185907
51FES0.82521364
52DYRK1A0.81610458
53DAPK10.80782589
54LATS10.79844387
55BCR0.79324780
56CAMK10.76913684
57WNK30.76846155
58LMTK20.75680626
59CAMK40.75241320
60CDK150.73764454
61CAMK2B0.73390726
62IRAK20.73313871
63OXSR10.72287916
64ERBB30.71676046
65GRK70.68228038
66DYRK20.67797634
67CDK140.67325218
68PHKG20.66730707
69PHKG10.66730707
70MAP3K140.63605847
71CDK11A0.62327111
72PAK30.59618807
73PRKCZ0.58410618
74WNK10.57886594
75SRPK10.57021355
76STK38L0.56329160
77NUAK10.55505972
78UHMK10.55100215
79MAPK120.53872804
80CAMKK10.53415978
81CDK190.52604387
82GRK10.52421904
83STK390.52291303
84MARK20.52202881
85GRK50.50294478
86CSNK1G10.49264099
87CAMK1G0.48991992
88ZAK0.47770154
89FGR0.45928514
90RET0.45382071
91CAMK2G0.45007624
92CSNK1G20.44195051
93EPHA30.43942995
94MAPK100.43223770
95KSR20.43105966
96FYN0.43030616
97BLK0.42206961
98RPS6KA30.42201414
99PRKG10.41618719
100IRAK40.41528293
101RPS6KB10.41261294
102CAMK2D0.41038584
103CSNK1A1L0.41002622
104PDK10.40433903
105CSNK1D0.40357817
106RAF10.39401050
107CAMK1D0.39374254
108PRKCH0.38873414
109STK110.38781009
110CSNK1E0.38560998
111PRKCB0.38366186
112NTRK10.38361900
113IRAK30.38184445
114CSNK1G30.37917002
115WNK40.36415937
116PIK3CA0.36304604
117JAK10.36145883
118AKT30.36130619
119MAP4K20.35976185
120GSK3B0.35756724
121ARAF0.35408976
122PRKCA0.35107419
123CDC42BPA0.35061161
124IRAK10.34632330
125PRKACA0.34617730
126ERBB20.34612230
127EPHB20.34602345
128MAPKAPK50.33929855
129CDK180.33323452
130FER0.33125514
131LYN0.32563396
132PRKACB0.32252625
133MAPK80.31841594
134LATS20.30368471

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.89681363
2Glutamatergic synapse_Homo sapiens_hsa047242.93692883
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.83559428
4Circadian entrainment_Homo sapiens_hsa047132.76844041
5Morphine addiction_Homo sapiens_hsa050322.74997961
6Olfactory transduction_Homo sapiens_hsa047402.74526571
7GABAergic synapse_Homo sapiens_hsa047272.52311195
8Amphetamine addiction_Homo sapiens_hsa050312.26379840
9Synaptic vesicle cycle_Homo sapiens_hsa047212.22565300
10Long-term potentiation_Homo sapiens_hsa047202.18835787
11Taste transduction_Homo sapiens_hsa047422.17465513
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.16584250
13Salivary secretion_Homo sapiens_hsa049702.00705715
14Insulin secretion_Homo sapiens_hsa049111.95810759
15Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.95501111
16Calcium signaling pathway_Homo sapiens_hsa040201.84701917
17Serotonergic synapse_Homo sapiens_hsa047261.82348591
18Dopaminergic synapse_Homo sapiens_hsa047281.78703449
19Cholinergic synapse_Homo sapiens_hsa047251.73907139
20Axon guidance_Homo sapiens_hsa043601.73262895
21Cocaine addiction_Homo sapiens_hsa050301.72879109
22Renin secretion_Homo sapiens_hsa049241.58796459
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.52708188
24Long-term depression_Homo sapiens_hsa047301.50352333
25Gastric acid secretion_Homo sapiens_hsa049711.41962224
26cAMP signaling pathway_Homo sapiens_hsa040241.36868467
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.31547469
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.27618781
29Oxytocin signaling pathway_Homo sapiens_hsa049211.21724200
30Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.20004851
31Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.19164210
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.18948015
33Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.13065165
34Nitrogen metabolism_Homo sapiens_hsa009101.07257525
35Melanogenesis_Homo sapiens_hsa049161.06375936
36GnRH signaling pathway_Homo sapiens_hsa049121.04731722
37Type II diabetes mellitus_Homo sapiens_hsa049301.02781483
38Gap junction_Homo sapiens_hsa045400.99666508
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.98631984
40Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.97696669
41Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.94984146
42Type I diabetes mellitus_Homo sapiens_hsa049400.93256471
43ErbB signaling pathway_Homo sapiens_hsa040120.89060113
44Phototransduction_Homo sapiens_hsa047440.87138710
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.86440808
46Phosphatidylinositol signaling system_Homo sapiens_hsa040700.85152238
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.81491415
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.78567160
49African trypanosomiasis_Homo sapiens_hsa051430.78270221
50Collecting duct acid secretion_Homo sapiens_hsa049660.78210784
51cGMP-PKG signaling pathway_Homo sapiens_hsa040220.77763545
52Dilated cardiomyopathy_Homo sapiens_hsa054140.75370670
53Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.74677283
54Bile secretion_Homo sapiens_hsa049760.74122912
55Choline metabolism in cancer_Homo sapiens_hsa052310.69647274
56Vascular smooth muscle contraction_Homo sapiens_hsa042700.68152313
57Wnt signaling pathway_Homo sapiens_hsa043100.68047058
58Pancreatic secretion_Homo sapiens_hsa049720.67615326
59MAPK signaling pathway_Homo sapiens_hsa040100.67298824
60Phospholipase D signaling pathway_Homo sapiens_hsa040720.65616222
61Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64392364
62Ovarian steroidogenesis_Homo sapiens_hsa049130.62691413
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61516619
64Estrogen signaling pathway_Homo sapiens_hsa049150.59411378
65SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58627224
66Rheumatoid arthritis_Homo sapiens_hsa053230.57383441
67Vibrio cholerae infection_Homo sapiens_hsa051100.57383084
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.56901264
69Platelet activation_Homo sapiens_hsa046110.54356680
70Ras signaling pathway_Homo sapiens_hsa040140.53881787
71Butanoate metabolism_Homo sapiens_hsa006500.53749320
72Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.53648555
73Chemokine signaling pathway_Homo sapiens_hsa040620.53225037
74Hippo signaling pathway_Homo sapiens_hsa043900.51487326
75Glioma_Homo sapiens_hsa052140.50274376
76Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49692333
77Graft-versus-host disease_Homo sapiens_hsa053320.48809164
78Rap1 signaling pathway_Homo sapiens_hsa040150.48033241
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47534702
80Circadian rhythm_Homo sapiens_hsa047100.47478477
81Ether lipid metabolism_Homo sapiens_hsa005650.46862468
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45946578
83Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.45898169
84Fatty acid biosynthesis_Homo sapiens_hsa000610.45390063
85Thyroid hormone synthesis_Homo sapiens_hsa049180.44561945
86Glucagon signaling pathway_Homo sapiens_hsa049220.39493774
87Hedgehog signaling pathway_Homo sapiens_hsa043400.38837221
88Mineral absorption_Homo sapiens_hsa049780.37964966
89Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37872188
90TNF signaling pathway_Homo sapiens_hsa046680.36999635
91Basal cell carcinoma_Homo sapiens_hsa052170.36764159
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.35244875
93ABC transporters_Homo sapiens_hsa020100.33397045
94Autoimmune thyroid disease_Homo sapiens_hsa053200.33018415
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.32993639
96Vitamin B6 metabolism_Homo sapiens_hsa007500.32559104
97Endometrial cancer_Homo sapiens_hsa052130.32253986
98Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32035305
99mTOR signaling pathway_Homo sapiens_hsa041500.31534460
100Inositol phosphate metabolism_Homo sapiens_hsa005620.30006332
101VEGF signaling pathway_Homo sapiens_hsa043700.29949489
102Tuberculosis_Homo sapiens_hsa051520.29577473
103Regulation of autophagy_Homo sapiens_hsa041400.29001152
104Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.28520072
105Alcoholism_Homo sapiens_hsa050340.28423453
106Oocyte meiosis_Homo sapiens_hsa041140.28306029
107Tight junction_Homo sapiens_hsa045300.27638929
108Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.27430991
109Dorso-ventral axis formation_Homo sapiens_hsa043200.26971185
110Phagosome_Homo sapiens_hsa041450.26556734
111Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.26506345
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26363061
113Melanoma_Homo sapiens_hsa052180.26180479
114Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.25637626
115Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.25489132
116Fanconi anemia pathway_Homo sapiens_hsa034600.25182970
117Cardiac muscle contraction_Homo sapiens_hsa042600.25133225
118NOD-like receptor signaling pathway_Homo sapiens_hsa046210.24201522
119Glycerolipid metabolism_Homo sapiens_hsa005610.24043788
120Asthma_Homo sapiens_hsa053100.24007553
121Renal cell carcinoma_Homo sapiens_hsa052110.23986669
122Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.23749340

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