DOK7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is essential for neuromuscular synaptogenesis. The protein functions in aneural activation of muscle-specific receptor kinase, which is required for postsynaptic differentiation, and in the subsequent clustering of the acetylcholine receptor in myotubes. This protein can also induce autophosphorylation of muscle-specific receptor kinase. Mutations in this gene are a cause of familial limb-girdle myasthenia autosomal recessive, which is also known as congenital myasthenic syndrome type 1B. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1striated muscle atrophy (GO:0014891)5.98005492
2sarcomere organization (GO:0045214)5.95249331
3cardiac myofibril assembly (GO:0055003)5.44534177
4negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.28895808
5positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.25736439
6plasma membrane repair (GO:0001778)5.19236453
7muscle filament sliding (GO:0030049)5.19223525
8actin-myosin filament sliding (GO:0033275)5.19223525
9regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)5.18213321
10regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO5.16608113
11skeletal muscle adaptation (GO:0043501)5.15889958
12sarcoplasmic reticulum calcium ion transport (GO:0070296)5.14130508
13muscle atrophy (GO:0014889)5.07748317
14response to muscle activity (GO:0014850)5.03305859
15regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.01222313
16myofibril assembly (GO:0030239)5.00316724
17negative regulation of potassium ion transmembrane transport (GO:1901380)4.94098524
18cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.89174142
19muscle cell fate commitment (GO:0042693)4.89089049
20regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.81733000
21cardiac muscle contraction (GO:0060048)4.81628793
22skeletal muscle fiber development (GO:0048741)4.79472426
23striated muscle adaptation (GO:0014888)4.70189811
24cell communication by electrical coupling (GO:0010644)4.66851580
25regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.49298515
26regulation of membrane repolarization (GO:0060306)4.40519972
27regulation of skeletal muscle contraction (GO:0014819)4.33193340
28striated muscle contraction (GO:0006941)4.30692589
29negative regulation of cell size (GO:0045792)4.29328455
30desmosome organization (GO:0002934)4.26786700
31regulation of actin filament-based movement (GO:1903115)4.26698364
32actin-mediated cell contraction (GO:0070252)4.21431231
33membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.20791007
34cell communication involved in cardiac conduction (GO:0086065)4.18551423
35regulation of relaxation of muscle (GO:1901077)4.16414935
36myotube cell development (GO:0014904)4.04806030
37positive regulation of myotube differentiation (GO:0010831)4.01562850
38ventricular cardiac muscle cell action potential (GO:0086005)3.96952718
39actomyosin structure organization (GO:0031032)3.89243857
40regulation of cell communication by electrical coupling (GO:0010649)3.88674719
41atrioventricular valve morphogenesis (GO:0003181)3.88662429
42adult heart development (GO:0007512)3.85404746
43regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.83672675
44focal adhesion assembly (GO:0048041)3.81664932
45cell-substrate adherens junction assembly (GO:0007045)3.81664932
46NADH metabolic process (GO:0006734)3.79339598
47cardiac muscle cell development (GO:0055013)3.75066369
48muscle adaptation (GO:0043500)3.73479916
49tricarboxylic acid cycle (GO:0006099)3.72013027
50skeletal muscle tissue development (GO:0007519)3.71329605
51positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.71123407
52cardiac muscle hypertrophy (GO:0003300)3.67200576
53skeletal muscle contraction (GO:0003009)3.64834371
54positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.64220435
55regulation of striated muscle contraction (GO:0006942)3.63692765
56creatine metabolic process (GO:0006600)3.58455301
57negative regulation of protein localization to cell surface (GO:2000009)3.56392853
58response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.54142455
59regulation of synapse structural plasticity (GO:0051823)3.53910060
60regulation of calcium ion transmembrane transporter activity (GO:1901019)3.53850196
61regulation of calcium ion transmembrane transport (GO:1903169)3.53850196
62striated muscle hypertrophy (GO:0014897)3.53779427
63myoblast fusion (GO:0007520)3.49843655
64cardiac cell development (GO:0055006)3.49426879
65muscle fiber development (GO:0048747)3.48533022
66adherens junction assembly (GO:0034333)3.48385019
67regulation of sarcomere organization (GO:0060297)3.47831214
68detection of calcium ion (GO:0005513)3.40117020
69positive regulation of potassium ion transmembrane transport (GO:1901381)3.37858116
70syncytium formation by plasma membrane fusion (GO:0000768)3.36081624
71cardiac muscle cell action potential (GO:0086001)3.31412345
72muscle organ development (GO:0007517)3.30306663
73regulation of cardiac muscle cell contraction (GO:0086004)3.28759634
74regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.28631256
75cardiac muscle cell action potential involved in contraction (GO:0086002)3.28530555
76glycogen catabolic process (GO:0005980)3.27765025
77cardiac muscle tissue morphogenesis (GO:0055008)3.24651620
78regulation of the force of heart contraction (GO:0002026)3.23363964
79actin filament-based movement (GO:0030048)3.22789084
80muscle structure development (GO:0061061)3.22103546
81epithelial cell-cell adhesion (GO:0090136)3.21815257
82glycogen biosynthetic process (GO:0005978)3.21761315
83glucan biosynthetic process (GO:0009250)3.21761315
84response to inactivity (GO:0014854)3.21689835
85muscle hypertrophy (GO:0014896)3.19149957
86regulation of acyl-CoA biosynthetic process (GO:0050812)3.17662885
87regulation of glucose import in response to insulin stimulus (GO:2001273)3.16341291
88regulation of cardiac muscle contraction (GO:0055117)3.12742717
89cell-substrate junction assembly (GO:0007044)3.11753482
90negative regulation of potassium ion transport (GO:0043267)3.11647646
91regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.10514709
92regulation of cardioblast differentiation (GO:0051890)3.08947864
93striated muscle tissue development (GO:0014706)3.08250069
94potassium ion import (GO:0010107)3.08214358
95negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)3.07382797
96cardiac conduction (GO:0061337)3.06757851
97outflow tract septum morphogenesis (GO:0003148)3.05955986
98positive regulation of cation channel activity (GO:2001259)3.04641864
99regulation of short-term neuronal synaptic plasticity (GO:0048172)3.02728770
100ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.01527422
101negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.01444313
102glucan catabolic process (GO:0009251)3.00700855
103muscle tissue morphogenesis (GO:0060415)3.00515294
104vocalization behavior (GO:0071625)3.00247014
105locomotory exploration behavior (GO:0035641)2.98927136
106sodium ion export (GO:0071436)2.98568214
107myotube differentiation (GO:0014902)2.97798448
108regulation of heart rate (GO:0002027)2.97500531
109muscle contraction (GO:0006936)2.96500316
110positive regulation of myoblast differentiation (GO:0045663)2.94333361
111negative regulation of cytosolic calcium ion concentration (GO:0051481)2.94323178
112regulation of coenzyme metabolic process (GO:0051196)2.94182505
113regulation of cofactor metabolic process (GO:0051193)2.94182505
114cardiac right ventricle morphogenesis (GO:0003215)2.93078613
115carnitine shuttle (GO:0006853)2.92779269
116muscle cell cellular homeostasis (GO:0046716)2.91442319
117regulation of heart rate by cardiac conduction (GO:0086091)2.90697549
118heart trabecula formation (GO:0060347)2.89467056
119regulation of heart contraction (GO:0008016)2.88121110
120regulation of potassium ion transmembrane transport (GO:1901379)2.87770718
121neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.87005536
122synaptic vesicle maturation (GO:0016188)2.85258604
123relaxation of cardiac muscle (GO:0055119)2.84466969
124membrane depolarization during action potential (GO:0086010)2.83778009
125regulation of cation channel activity (GO:2001257)2.83776256
126regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.81710132
127muscle cell development (GO:0055001)2.79309683
128cardiac muscle hypertrophy in response to stress (GO:0014898)2.77304116
129muscle hypertrophy in response to stress (GO:0003299)2.77304116
130cardiac muscle adaptation (GO:0014887)2.77304116
131muscle system process (GO:0003012)2.76617920
132bundle of His cell to Purkinje myocyte communication (GO:0086069)2.76505848
133regulation of fatty acid oxidation (GO:0046320)2.76229646
134regulation of potassium ion transmembrane transporter activity (GO:1901016)2.75623928
135regulation of myoblast differentiation (GO:0045661)2.74058134
136regulation of myotube differentiation (GO:0010830)2.73625128
137cellular polysaccharide catabolic process (GO:0044247)2.73474340
138positive regulation of potassium ion transport (GO:0043268)2.72904181
139neuronal action potential propagation (GO:0019227)2.72727347
140regulation of fatty acid beta-oxidation (GO:0031998)2.72652325
141synaptic vesicle exocytosis (GO:0016079)2.71860994
142regulation of glutamate receptor signaling pathway (GO:1900449)2.71659313
143striated muscle cell development (GO:0055002)2.70691290
144cellular potassium ion homeostasis (GO:0030007)2.68478035
145muscle tissue development (GO:0060537)2.67643879
146activation of protein kinase A activity (GO:0034199)2.67379201
147hemidesmosome assembly (GO:0031581)2.67251746
148positive regulation of sodium ion transport (GO:0010765)2.66312298

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.03232571
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.96392330
3* ESR1_21235772_ChIP-Seq_MCF-7_Human3.72299560
4RACK7_27058665_Chip-Seq_MCF-7_Human3.06362765
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.91750674
6LXR_22292898_ChIP-Seq_THP-1_Human2.81316051
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.66896620
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.48855834
9TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.43552650
10EP300_21415370_ChIP-Seq_HL-1_Mouse2.30531973
11* RUNX1_27514584_Chip-Seq_MCF-7_Human2.28404733
12ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.26881481
13* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.25114524
14DROSHA_22980978_ChIP-Seq_HELA_Human2.24830784
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.20184806
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.20184806
17JARID2_20064375_ChIP-Seq_MESCs_Mouse2.18488287
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.15642576
19GBX2_23144817_ChIP-Seq_PC3_Human2.14418407
20* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.13230049
21RARB_27405468_Chip-Seq_BRAIN_Mouse2.08981111
22VDR_21846776_ChIP-Seq_THP-1_Human2.03144726
23JARID2_20075857_ChIP-Seq_MESCs_Mouse2.00842188
24SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.00108105
25* EZH2_27294783_Chip-Seq_ESCs_Mouse2.00100934
26EZH2_27304074_Chip-Seq_ESCs_Mouse1.97519880
27SUZ12_27294783_Chip-Seq_ESCs_Mouse1.92039482
28ELK3_25401928_ChIP-Seq_HUVEC_Human1.90543039
29P68_20966046_ChIP-Seq_HELA_Human1.89238456
30STAT6_21828071_ChIP-Seq_BEAS2B_Human1.87880719
31SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.87791730
32MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.86535153
33TET1_21451524_ChIP-Seq_MESCs_Mouse1.83217372
34KDM2B_26808549_Chip-Seq_DND41_Human1.82631527
35REST_21632747_ChIP-Seq_MESCs_Mouse1.80802139
36HIF1A_21447827_ChIP-Seq_MCF-7_Human1.79512013
37RNF2_27304074_Chip-Seq_ESCs_Mouse1.79427514
38* TCF7_22412390_ChIP-Seq_EML_Mouse1.79204792
39CDX2_19796622_ChIP-Seq_MESCs_Mouse1.78051906
40KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.76517624
41ESR1_15608294_ChIP-ChIP_MCF-7_Human1.75445367
42TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.72445140
43SMC4_20622854_ChIP-Seq_HELA_Human1.72216149
44ESR1_20079471_ChIP-ChIP_T-47D_Human1.71208180
45* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.70813992
46TBX20_22328084_ChIP-Seq_HEART_Mouse1.66732908
47TBX20_22080862_ChIP-Seq_HEART_Mouse1.66732908
48EED_16625203_ChIP-ChIP_MESCs_Mouse1.62548447
49THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.60122697
50AR_21572438_ChIP-Seq_LNCaP_Human1.59371516
51REST_18959480_ChIP-ChIP_MESCs_Mouse1.57285613
52CTCF_27219007_Chip-Seq_ERYTHROID_Human1.56215767
53SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.55536190
54RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53963365
55RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.49269651
56SA1_27219007_Chip-Seq_ERYTHROID_Human1.48102309
57TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.47025130
58TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43212675
59CREB1_26743006_Chip-Seq_LNCaP_Human1.41790526
60KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.41580070
61EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.39486289
62ATF3_27146783_Chip-Seq_COLON_Human1.36952629
63NR3C1_23031785_ChIP-Seq_PC12_Mouse1.36244375
64MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.36126074
65UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.36063034
66* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.34444733
67ZNF274_21170338_ChIP-Seq_K562_Hela1.34073257
68SMAD4_21799915_ChIP-Seq_A2780_Human1.29523349
69PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.27736704
70TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27012764
71KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.26284115
72P63_26484246_Chip-Seq_KERATINOCYTES_Human1.25649054
73MYC_22102868_ChIP-Seq_BL_Human1.25539188
74SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.25205598
75PPARA_22158963_ChIP-Seq_LIVER_Mouse1.25084363
76NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.24373498
77CTCF_21964334_Chip-Seq_Bcells_Human1.23111713
78DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.22445153
79SOX2_21211035_ChIP-Seq_LN229_Gbm1.22380457
80NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.22039160
81PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.21203711
82* TP63_22573176_ChIP-Seq_HFKS_Human1.21042762
83CTCF_21964334_ChIP-Seq_BJAB-B_Human1.20898467
84SMC3_22415368_ChIP-Seq_MEFs_Mouse1.20638514
85EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.18427221
86BCOR_27268052_Chip-Seq_Bcells_Human1.18372933
87* ESR2_21235772_ChIP-Seq_MCF-7_Human1.17902350
88CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.15641779
89WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15216334
90ERG_21242973_ChIP-ChIP_JURKAT_Human1.14649253
91NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.14603417
92ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.14141889
93RING1B_27294783_Chip-Seq_ESCs_Mouse1.14091852
94SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.13231100
95IKZF1_21737484_ChIP-ChIP_HCT116_Human1.13089597
96CTCF_26484167_Chip-Seq_Bcells_Mouse1.13053706
97DNAJC2_21179169_ChIP-ChIP_NT2_Human1.12534544
98RXR_22158963_ChIP-Seq_LIVER_Mouse1.12200740
99PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.11779727
100BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.11370983
101P300_27058665_Chip-Seq_ZR-75-30cells_Human1.11083512
102ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.11043477
103SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10730526
104CTCF_27219007_Chip-Seq_Bcells_Human1.10676419
105BCL6_27268052_Chip-Seq_Bcells_Human1.09925713
106SA1_27219007_Chip-Seq_Bcells_Human1.09918724
107CTBP1_25329375_ChIP-Seq_LNCAP_Human1.09045023
108RARB_24833708_ChIP-Seq_LIVER_Mouse1.08891894
109CTBP2_25329375_ChIP-Seq_LNCAP_Human1.08842967
110GATA3_24758297_ChIP-Seq_MCF-7_Human1.07892086
111KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.07544746
112SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.07004186
113E2F1_20622854_ChIP-Seq_HELA_Human1.06891491
114MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.06590230
115AR_19668381_ChIP-Seq_PC3_Human1.06362571
116* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.06000907
117STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.05951883
118CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.05320411
119* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04695825
120KDM2B_26808549_Chip-Seq_K562_Human1.04428855
121GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03567753
122SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03340811
123AHR_22903824_ChIP-Seq_MCF-7_Human1.03330431
124RARG_19884340_ChIP-ChIP_MEFs_Mouse1.03039868
125TP53_22127205_ChIP-Seq_IMR90_Human1.02982342
126SMAD3_21741376_ChIP-Seq_EPCs_Human1.02913026
127BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01913050
128ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00661304
129SMAD4_21741376_ChIP-Seq_HESCs_Human0.99891431
130SMAD3_21741376_ChIP-Seq_HESCs_Human0.99778713
131TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99773151
132SRY_22984422_ChIP-ChIP_TESTIS_Rat0.99273893
133BCAT_22108803_ChIP-Seq_LS180_Human0.98967280
134STAT3_1855785_ChIP-Seq_MESCs_Mouse0.98309317
135ARNT_22903824_ChIP-Seq_MCF-7_Human0.98016804
136TRIM28_21343339_ChIP-Seq_HEK293_Human0.97420992
137* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.97119255
138JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.96733183
139NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.95116799
140MAF_26560356_Chip-Seq_TH2_Human0.94911181
141* TDRD3_21172665_ChIP-Seq_MCF-7_Human0.94765962
142ZFP281_18757296_ChIP-ChIP_E14_Mouse0.94587009
143CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.94573890
144* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94471029
145TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94273331
146AR_25329375_ChIP-Seq_VCAP_Human0.93863642
147PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.92724690
148SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.92609865
149FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.92554597
150RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.91900168
151TP53_23651856_ChIP-Seq_MEFs_Mouse0.91678423
152ELF1_20517297_ChIP-Seq_JURKAT_Human0.91426282
153* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91053057
154WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.90806078
155MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90714501
156PIAS1_25552417_ChIP-Seq_VCAP_Human0.90449922
157CBX2_27304074_Chip-Seq_ESCs_Mouse0.90324029
158ZNF263_19887448_ChIP-Seq_K562_Human0.87413239
159TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87110696
160GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86765226
161TOP2B_26459242_ChIP-Seq_MCF-7_Human0.86683466
162KDM2B_26808549_Chip-Seq_SUP-B15_Human0.86602379
163TP53_16413492_ChIP-PET_HCT116_Human0.86487010
164* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.86253477
165BP1_19119308_ChIP-ChIP_Hs578T_Human0.86045300
166YAP1_20516196_ChIP-Seq_MESCs_Mouse0.85145606
167ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.84848575
168STAT3_23295773_ChIP-Seq_U87_Human0.83759450
169TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.83300728
170ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.83221619
171SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.81744341
172CTNNB1_20460455_ChIP-Seq_HCT116_Human0.80152733
173* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.79852645

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.53463362
2MP0000751_myopathy4.88970357
3MP0003646_muscle_fatigue4.77205463
4MP0004084_abnormal_cardiac_muscle3.89334717
5MP0004215_abnormal_myocardial_fiber3.85447540
6MP0000749_muscle_degeneration3.56693609
7MP0004036_abnormal_muscle_relaxation3.26185896
8MP0003705_abnormal_hypodermis_morpholog3.18325313
9MP0004859_abnormal_synaptic_plasticity2.84799497
10MP0005330_cardiomyopathy2.80190600
11MP0004145_abnormal_muscle_electrophysio2.61572454
12MP0004087_abnormal_muscle_fiber2.57193026
13MP0003137_abnormal_impulse_conducting2.53765632
14MP0000750_abnormal_muscle_regeneration2.47334416
15MP0002972_abnormal_cardiac_muscle2.45921511
16MP0005451_abnormal_body_composition2.43018581
17MP0004270_analgesia2.30721388
18MP0002106_abnormal_muscle_physiology2.27477698
19MP0005620_abnormal_muscle_contractility2.26038620
20MP0004130_abnormal_muscle_cell2.15012784
21MP0000747_muscle_weakness2.09421335
22MP0002269_muscular_atrophy1.99408562
23MP0004233_abnormal_muscle_weight1.96718904
24MP0004484_altered_response_of1.95698980
25MP0003635_abnormal_synaptic_transmissio1.92775714
26MP0005369_muscle_phenotype1.88024081
27MP0000759_abnormal_skeletal_muscle1.87048337
28MP0004085_abnormal_heartbeat1.85961332
29MP0009780_abnormal_chondrocyte_physiolo1.81724919
30MP0008775_abnormal_heart_ventricle1.81214557
31MP0003880_abnormal_central_pattern1.77943444
32MP0010234_abnormal_vibrissa_follicle1.76361078
33MP0005385_cardiovascular_system_phenoty1.73602338
34MP0001544_abnormal_cardiovascular_syste1.73602338
35MP0006138_congestive_heart_failure1.73442555
36MP0009046_muscle_twitch1.68671823
37MP0010630_abnormal_cardiac_muscle1.66435087
38MP0000579_abnormal_nail_morphology1.65423268
39MP0009745_abnormal_behavioral_response1.65075296
40MP0004510_myositis1.63204228
41MP0002249_abnormal_larynx_morphology1.58369819
42MP0004381_abnormal_hair_follicle1.56787690
43MP0002064_seizures1.52973616
44MP0002822_catalepsy1.52893604
45MP0002909_abnormal_adrenal_gland1.48595174
46MP0002063_abnormal_learning/memory/cond1.46385701
47MP0005076_abnormal_cell_differentiation1.45283999
48MP0001440_abnormal_grooming_behavior1.36438040
49MP0003329_amyloid_beta_deposits1.35686899
50MP0001661_extended_life_span1.33713498
51MP0008569_lethality_at_weaning1.31873113
52MP0002572_abnormal_emotion/affect_behav1.31341287
53MP0001486_abnormal_startle_reflex1.30278393
54MP0004858_abnormal_nervous_system1.27912134
55MP0009384_cardiac_valve_regurgitation1.26761040
56MP0010030_abnormal_orbit_morphology1.25493918
57MP0000467_abnormal_esophagus_morphology1.24716225
58MP0000003_abnormal_adipose_tissue1.23851465
59MP0002272_abnormal_nervous_system1.23750470
60MP0000013_abnormal_adipose_tissue1.23130884
61MP0003950_abnormal_plasma_membrane1.21161901
62MP0002796_impaired_skin_barrier1.18842102
63MP0001501_abnormal_sleep_pattern1.18391514
64MP0002332_abnormal_exercise_endurance1.16970563
65MP0002734_abnormal_mechanical_nocicepti1.16714522
66MP0004924_abnormal_behavior1.12753924
67MP0005386_behavior/neurological_phenoty1.12753924
68MP0000462_abnormal_digestive_system1.11722203
69MP0005409_darkened_coat_color1.09190784
70MP0003221_abnormal_cardiomyocyte_apopto1.08663551
71MP0002127_abnormal_cardiovascular_syste1.07408396
72MP0003828_pulmonary_edema1.07265829
73MP0002735_abnormal_chemical_nociception1.07081051
74MP0004885_abnormal_endolymph1.05842755
75MP0000762_abnormal_tongue_morphology1.05392177
76MP0001348_abnormal_lacrimal_gland1.05050146
77MP0004185_abnormal_adipocyte_glucose1.04811772
78MP0005623_abnormal_meninges_morphology1.02800471
79MP0002067_abnormal_sensory_capabilities1.00918646
80MP0003878_abnormal_ear_physiology0.98503932
81MP0005377_hearing/vestibular/ear_phenot0.98503932
82MP0002108_abnormal_muscle_morphology0.98476117
83MP0005423_abnormal_somatic_nervous0.97448773
84MP0000383_abnormal_hair_follicle0.96489161
85MP0004264_abnormal_extraembryonic_tissu0.96407893
86MP0001968_abnormal_touch/_nociception0.95276489
87MP0005666_abnormal_adipose_tissue0.94732798
88MP0006036_abnormal_mitochondrial_physio0.94322220
89MP0000767_abnormal_smooth_muscle0.89765419
90MP0003633_abnormal_nervous_system0.89183256
91MP0003566_abnormal_cell_adhesion0.88768005
92MP0005083_abnormal_biliary_tract0.87379327
93MP0005501_abnormal_skin_physiology0.86023088
94MP0002234_abnormal_pharynx_morphology0.84200238
95MP0001849_ear_inflammation0.83800618
96MP0000733_abnormal_muscle_development0.83093916
97MP0001299_abnormal_eye_distance/0.82896103
98MP0001970_abnormal_pain_threshold0.81870301
99MP0008961_abnormal_basal_metabolism0.81673386
100MP0001502_abnormal_circadian_rhythm0.81396019
101MP0002254_reproductive_system_inflammat0.80762598
102MP0003690_abnormal_glial_cell0.79353450
103MP0003453_abnormal_keratinocyte_physiol0.79069339
104MP0002098_abnormal_vibrissa_morphology0.78617074
105* MP0002066_abnormal_motor_capabilities/c0.78262081
106MP0004043_abnormal_pH_regulation0.77778253
107MP0000377_abnormal_hair_follicle0.77476014
108MP0002089_abnormal_postnatal_growth/wei0.76844344
109MP0010678_abnormal_skin_adnexa0.75755412
110MP0000266_abnormal_heart_morphology0.75374890
111MP0005165_increased_susceptibility_to0.74749916
112MP0002736_abnormal_nociception_after0.74154090
113MP0000537_abnormal_urethra_morphology0.73923805
114MP0005375_adipose_tissue_phenotype0.73171307
115MP0005187_abnormal_penis_morphology0.72799468
116MP0003279_aneurysm0.72618505
117MP0002733_abnormal_thermal_nociception0.71999798
118MP0002557_abnormal_social/conspecific_i0.71409506
119MP0001346_abnormal_lacrimal_gland0.70558519
120MP0003634_abnormal_glial_cell0.69970964
121MP0005670_abnormal_white_adipose0.68777772
122MP0000534_abnormal_ureter_morphology0.68705716
123MP0001485_abnormal_pinna_reflex0.68635084
124MP0005646_abnormal_pituitary_gland0.68498366
125MP0005535_abnormal_body_temperature0.67573068
126MP0000678_abnormal_parathyroid_gland0.67500738
127MP0000343_altered_response_to0.66499064
128MP0000955_abnormal_spinal_cord0.65344919
129MP0004811_abnormal_neuron_physiology0.64251935
130MP0003631_nervous_system_phenotype0.63524107
131MP0003879_abnormal_hair_cell0.63257108
132MP0000230_abnormal_systemic_arterial0.62525870
133MP0000538_abnormal_urinary_bladder0.61967925
134MP0002971_abnormal_brown_adipose0.61515952
135MP0004142_abnormal_muscle_tone0.61475006
136MP0001529_abnormal_vocalization0.60896111
137* MP0002184_abnormal_innervation0.60725653
138MP0002877_abnormal_melanocyte_morpholog0.60012011
139MP0005266_abnormal_metabolism0.59346077
140MP0002060_abnormal_skin_morphology0.58102924
141MP0002896_abnormal_bone_mineralization0.58090693
142MP0003942_abnormal_urinary_system0.57567599
143MP0009840_abnormal_foam_cell0.55619355
144MP0002932_abnormal_joint_morphology0.51340902
145MP0000470_abnormal_stomach_morphology0.48557902
146MP0001727_abnormal_embryo_implantation0.47771318
147MP0003123_paternal_imprinting0.47006922
148MP0001542_abnormal_bone_strength0.46367134
149MP0003091_abnormal_cell_migration0.45750631
150MP0002128_abnormal_blood_circulation0.43435314

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)6.59573675
2Exercise-induced myalgia (HP:0003738)5.90618979
3Calf muscle hypertrophy (HP:0008981)5.86626791
4Muscle hypertrophy of the lower extremities (HP:0008968)5.51137784
5Muscle fiber splitting (HP:0003555)5.24537210
6Abnormality of the calf musculature (HP:0001430)5.20437612
7Exercise-induced muscle cramps (HP:0003710)5.18714408
8Atrial fibrillation (HP:0005110)4.77515749
9Hyporeflexia of lower limbs (HP:0002600)4.69217730
10Ventricular tachycardia (HP:0004756)4.63772402
11Primary atrial arrhythmia (HP:0001692)4.52194667
12Supraventricular tachycardia (HP:0004755)4.29663719
13EMG: myopathic abnormalities (HP:0003458)4.24379203
14Difficulty running (HP:0009046)4.22143325
15Bundle branch block (HP:0011710)4.21494568
16Supraventricular arrhythmia (HP:0005115)4.18782112
17Syncope (HP:0001279)4.04720427
18Aplasia of the musculature (HP:0100854)3.91878372
19Prolonged QT interval (HP:0001657)3.91283462
20Abnormality of the left ventricular outflow tract (HP:0011103)3.82397118
21Subaortic stenosis (HP:0001682)3.82397118
22Myoglobinuria (HP:0002913)3.79815937
23Lipoatrophy (HP:0100578)3.72705847
24Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.68374663
25Muscle fiber inclusion bodies (HP:0100299)3.68246310
26Heart block (HP:0012722)3.59074748
27Right ventricular cardiomyopathy (HP:0011663)3.58581901
28Abnormality of placental membranes (HP:0011409)3.51553424
29Amniotic constriction ring (HP:0009775)3.51553424
30Ventricular fibrillation (HP:0001663)3.51486309
31Myotonia (HP:0002486)3.42740814
32Focal motor seizures (HP:0011153)3.42175508
33Abnormal atrioventricular conduction (HP:0005150)3.40593466
34Type 2 muscle fiber atrophy (HP:0003554)3.40250941
35Type 1 muscle fiber predominance (HP:0003803)3.40191725
36Atrioventricular block (HP:0001678)3.39628241
37Muscle fiber atrophy (HP:0100295)3.39568764
38Ventricular arrhythmia (HP:0004308)3.35396355
39Asymmetric septal hypertrophy (HP:0001670)3.32098568
40* Bulbar palsy (HP:0001283)3.26203992
41Difficulty climbing stairs (HP:0003551)3.24920149
42* Easy fatigability (HP:0003388)3.17421612
43Dilated cardiomyopathy (HP:0001644)3.15269043
44Increased connective tissue (HP:0009025)3.09901302
45Fetal akinesia sequence (HP:0001989)3.03998234
46Palpitations (HP:0001962)3.02284894
47Abnormal EKG (HP:0003115)3.00263783
48Nemaline bodies (HP:0003798)2.94623068
49Absent phalangeal crease (HP:0006109)2.81841112
50Progressive muscle weakness (HP:0003323)2.75494613
51Increased variability in muscle fiber diameter (HP:0003557)2.73144541
52* Pterygium (HP:0001059)2.70963145
53Left ventricular hypertrophy (HP:0001712)2.68116867
54Akinesia (HP:0002304)2.65382079
55Abnormality of skeletal muscle fiber size (HP:0012084)2.58975069
56Round ear (HP:0100830)2.56838503
57Pheochromocytoma (HP:0002666)2.56759425
58Neck muscle weakness (HP:0000467)2.55682626
59Myokymia (HP:0002411)2.53417415
60Calcaneovalgus deformity (HP:0001848)2.53020180
61* Gowers sign (HP:0003391)2.52476900
62Muscle stiffness (HP:0003552)2.50661614
63Ragged-red muscle fibers (HP:0003200)2.46767450
64Distal arthrogryposis (HP:0005684)2.39537135
65Abnormal finger flexion creases (HP:0006143)2.36316019
66Lower limb amyotrophy (HP:0007210)2.34329267
67Distal lower limb amyotrophy (HP:0008944)2.34142116
68Limb-girdle muscle atrophy (HP:0003797)2.32635552
69Nonprogressive disorder (HP:0003680)2.32357906
70Hypoplastic heart (HP:0001961)2.30982673
71* Thin ribs (HP:0000883)2.24453192
72Dysmetric saccades (HP:0000641)2.23330682
73Rhabdomyolysis (HP:0003201)2.23329886
74Visual hallucinations (HP:0002367)2.22214588
75Neuroendocrine neoplasm (HP:0100634)2.22127724
76Deformed tarsal bones (HP:0008119)2.16072381
77Distal lower limb muscle weakness (HP:0009053)2.15021248
78Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.14624079
79EMG: neuropathic changes (HP:0003445)2.10987238
80Abnormality of the foot musculature (HP:0001436)2.10443408
81Foot dorsiflexor weakness (HP:0009027)2.09815174
82Testicular atrophy (HP:0000029)2.08498846
83Hypoplastic ischia (HP:0003175)2.08493641
84* Mildly elevated creatine phosphokinase (HP:0008180)2.07650238
85Focal seizures (HP:0007359)2.07456883
86J-shaped sella turcica (HP:0002680)2.05317692
87Areflexia of lower limbs (HP:0002522)2.03872021
88Rapidly progressive (HP:0003678)2.03809825
89Generalized muscle weakness (HP:0003324)2.03156272
90Aplasia/Hypoplasia involving the musculature (HP:0001460)2.02500192
91Centrally nucleated skeletal muscle fibers (HP:0003687)2.00343713
92Myopathic facies (HP:0002058)1.98397628
93Spinal rigidity (HP:0003306)1.96807542
94Scapular winging (HP:0003691)1.96664462
95Muscular dystrophy (HP:0003560)1.96234780
96* Respiratory insufficiency due to muscle weakness (HP:0002747)1.96215811
97Acute necrotizing encephalopathy (HP:0006965)1.95173519
98Abnormal mitochondria in muscle tissue (HP:0008316)1.95065191
99Large for gestational age (HP:0001520)1.91301935
100Palmoplantar keratoderma (HP:0000982)1.90097460
101Epileptic encephalopathy (HP:0200134)1.89602747
102Hip contracture (HP:0003273)1.89150572
103* Generalized amyotrophy (HP:0003700)1.87160987
104* Fatigable weakness (HP:0003473)1.85357027
105* Abnormality of the neuromuscular junction (HP:0003398)1.85357027
106Athetosis (HP:0002305)1.81069174
107Thin bony cortex (HP:0002753)1.80951162
108Hypoplastic left heart (HP:0004383)1.80500795
109Abnormality of the ischium (HP:0003174)1.79311441
110Rimmed vacuoles (HP:0003805)1.77701914
111Malignant hyperthermia (HP:0002047)1.76853864
112Weak cry (HP:0001612)1.76618079
113Ulnar deviation of the wrist (HP:0003049)1.76292894
114Ketoacidosis (HP:0001993)1.74922508
115Generalized tonic-clonic seizures (HP:0002069)1.72864703
116* Waddling gait (HP:0002515)1.71795558
117Facial diplegia (HP:0001349)1.71547100
118Sudden cardiac death (HP:0001645)1.71202801
119Metatarsus adductus (HP:0001840)1.70495906
120Hyperkalemia (HP:0002153)1.70425511
121Bradycardia (HP:0001662)1.69177749
122Hyperacusis (HP:0010780)1.68877198
123Popliteal pterygium (HP:0009756)1.68483103
124Progressive macrocephaly (HP:0004481)1.68389193
125Diaphragmatic weakness (HP:0009113)1.67926570
126Frequent falls (HP:0002359)1.66451334
127Neoplasm of the peripheral nervous system (HP:0100007)1.64620171
128Stridor (HP:0010307)1.58561387
129Abnormality of the shoulder girdle musculature (HP:0001435)1.57196211

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK14.54066347
2* MUSK3.91004121
3OBSCN3.90194679
4PHKG13.88961626
5PHKG23.88961626
6TTN3.61713064
7LMTK23.39733800
8TRIB33.28402329
9MAPKAPK32.88330830
10PDK42.67824090
11PDK32.67824090
12EPHA22.49536118
13EPHA42.39880262
14DMPK2.32429186
15NTRK32.24813811
16PINK12.04667575
17IRAK31.99862564
18PRKD31.89737113
19RPS6KB21.87323087
20MYLK1.84845726
21EEF2K1.79463909
22PDK21.78212022
23MAP2K21.67934740
24MAP3K41.56796598
25MAP3K91.54115724
26TESK11.53176528
27PKN21.51289547
28SMG11.50818848
29PIK3CG1.48833366
30PIK3CA1.41493765
31NTRK21.40449681
32NTRK11.37503100
33STK381.36138923
34PAK61.30987949
35MAPK121.30493607
36GRK61.26480539
37CAMK2D1.24197808
38PAK31.23517030
39NEK11.21937354
40MINK11.19968411
41MARK11.16671390
42LIMK11.16014409
43MST1R1.13146103
44MAP2K41.11146998
45CAMK2A1.08224495
46DAPK21.08219885
47ILK1.07888211
48ERN11.07842581
49TNIK1.07399037
50MAP2K71.06161016
51PRKD11.05812686
52KSR21.05732085
53MAP3K71.05162825
54MAPK151.04017085
55PAK41.03535255
56NME21.03372981
57GRK71.01553947
58STK240.99020677
59NME10.97666623
60MAP3K60.97004264
61PTK2B0.95849466
62RPS6KL10.95394619
63RPS6KC10.95394619
64ROCK10.93566980
65PTK60.92786501
66CDC42BPA0.92212577
67MAP2K30.86586451
68MTOR0.86083173
69CDK50.84607838
70SCYL20.84461792
71VRK20.83223525
72ICK0.81938863
73CAMKK10.81814760
74PRPF4B0.80595351
75RIPK10.79888152
76CASK0.79687281
77ROCK20.79253648
78RPS6KA60.79007098
79PRKCE0.78387726
80MOS0.77106658
81DAPK30.74757830
82WNK10.74579027
83TRPM70.74526700
84PRKCH0.73270701
85PKN10.71327428
86PDPK10.69559016
87WNK40.69262555
88CAMK2G0.68944538
89PRKAA10.68203455
90MAP2K10.66874526
91TNK20.66691715
92INSRR0.66676426
93CAMK10.64920718
94TBK10.63113906
95MAP3K50.61909462
96FGFR40.61519644
97PRKCI0.60165399
98PDK10.59683401
99PRKD20.59602402
100SGK10.58579463
101SGK30.57240131
102BCKDK0.57179051
103FER0.55911362
104MAP3K100.55755748
105SGK2230.55582712
106SGK4940.55582712
107NEK60.55192383
108PTK20.55168404
109TAOK10.55093738
110MAPK110.54803298
111UHMK10.53712089
112TYRO30.53499122
113CHUK0.52840514
114RPS6KA10.51270274
115PRKCG0.50862388
116PRKACB0.50844326
117MAP3K10.50811536
118GRK50.50660207
119RET0.50386161
120MET0.50160046
121TAOK20.49516604
122PRKACA0.48605418
123RPS6KA30.48412770
124LATS20.48195569
125MARK20.47497464
126ARAF0.47460826
127MAPKAPK20.47019237
128STK110.45885900
129MAPK130.45734777
130PIM20.45624956
131KSR10.44937552
132PDGFRA0.44829694
133RIPK40.44707156
134CAMK40.44606091
135TIE10.43497389
136MAPK40.43354245
137PRKACG0.43255536
138CAMK2B0.42954905
139MAPK70.42536268
140CDK150.41921355
141RPS6KA20.41071406
142PLK20.40863995
143DYRK1B0.40670669
144IRAK20.40366801
145MAP3K30.40165193
146PRKAA20.39995834
147AKT20.39924354
148PRKG10.39795242
149CDK180.39166339
150LRRK20.34272458
151EPHB10.31796262
152RPS6KB10.30614376
153TESK20.29868057
154MELK0.26644400
155BRAF0.26597448
156HIPK20.22287392
157BMX0.22188359
158MAPK80.22155771

Predicted pathways (KEGG)

RankGene SetZ-score
1Cardiac muscle contraction_Homo sapiens_hsa042603.54038767
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.33709063
3Dilated cardiomyopathy_Homo sapiens_hsa054143.06360837
4Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.81524228
5Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.20254641
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.15022140
7Sulfur relay system_Homo sapiens_hsa041222.12149484
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.09904520
9Pentose phosphate pathway_Homo sapiens_hsa000302.08238695
10Oxidative phosphorylation_Homo sapiens_hsa001902.06430455
11Parkinsons disease_Homo sapiens_hsa050121.98928964
12Circadian entrainment_Homo sapiens_hsa047131.86518787
13Alzheimers disease_Homo sapiens_hsa050101.73661190
14Nicotine addiction_Homo sapiens_hsa050331.73462888
15GABAergic synapse_Homo sapiens_hsa047271.69435902
16Insulin secretion_Homo sapiens_hsa049111.62271104
17Synaptic vesicle cycle_Homo sapiens_hsa047211.60441876
18Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.60060894
19Calcium signaling pathway_Homo sapiens_hsa040201.54875007
20Olfactory transduction_Homo sapiens_hsa047401.54823254
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.53760873
22Gastric acid secretion_Homo sapiens_hsa049711.51033270
23Long-term potentiation_Homo sapiens_hsa047201.47168538
24Glutamatergic synapse_Homo sapiens_hsa047241.45863760
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.44904696
26Morphine addiction_Homo sapiens_hsa050321.44667445
27Oxytocin signaling pathway_Homo sapiens_hsa049211.43014989
28Arginine biosynthesis_Homo sapiens_hsa002201.36687557
29Salivary secretion_Homo sapiens_hsa049701.34734215
30Amphetamine addiction_Homo sapiens_hsa050311.34108750
31Endometrial cancer_Homo sapiens_hsa052131.33032635
32Propanoate metabolism_Homo sapiens_hsa006401.32376388
33Thyroid cancer_Homo sapiens_hsa052161.31930713
34Notch signaling pathway_Homo sapiens_hsa043301.31107613
35Phenylalanine metabolism_Homo sapiens_hsa003601.30609898
36Fatty acid biosynthesis_Homo sapiens_hsa000611.29705813
37Cholinergic synapse_Homo sapiens_hsa047251.26654434
38Fatty acid metabolism_Homo sapiens_hsa012121.26177345
39Renin secretion_Homo sapiens_hsa049241.25769324
40Arginine and proline metabolism_Homo sapiens_hsa003301.24740664
41cGMP-PKG signaling pathway_Homo sapiens_hsa040221.24606169
42Aldosterone synthesis and secretion_Homo sapiens_hsa049251.22880214
43Fatty acid degradation_Homo sapiens_hsa000711.18851908
44Huntingtons disease_Homo sapiens_hsa050161.17340587
45Dopaminergic synapse_Homo sapiens_hsa047281.15430643
46Taste transduction_Homo sapiens_hsa047421.14901635
47Glucagon signaling pathway_Homo sapiens_hsa049221.12643400
48Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.11822610
49Type II diabetes mellitus_Homo sapiens_hsa049301.07903941
50Carbon metabolism_Homo sapiens_hsa012001.04485105
51Galactose metabolism_Homo sapiens_hsa000521.03227763
52cAMP signaling pathway_Homo sapiens_hsa040241.02866326
53Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.02660680
54Cyanoamino acid metabolism_Homo sapiens_hsa004601.01956905
55Acute myeloid leukemia_Homo sapiens_hsa052210.99834891
56Bladder cancer_Homo sapiens_hsa052190.96400205
57GnRH signaling pathway_Homo sapiens_hsa049120.95351835
58Dorso-ventral axis formation_Homo sapiens_hsa043200.94179981
59Cocaine addiction_Homo sapiens_hsa050300.93945860
60Vascular smooth muscle contraction_Homo sapiens_hsa042700.92251673
61ECM-receptor interaction_Homo sapiens_hsa045120.91123393
62Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.90493880
63Adipocytokine signaling pathway_Homo sapiens_hsa049200.90399933
64Serotonergic synapse_Homo sapiens_hsa047260.88337477
65Gap junction_Homo sapiens_hsa045400.88241938
66Insulin signaling pathway_Homo sapiens_hsa049100.86335451
67Collecting duct acid secretion_Homo sapiens_hsa049660.84964034
68Circadian rhythm_Homo sapiens_hsa047100.84609038
69Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.80214457
70Lysine degradation_Homo sapiens_hsa003100.78318296
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75717989
72Insulin resistance_Homo sapiens_hsa049310.74700785
73Estrogen signaling pathway_Homo sapiens_hsa049150.73349697
74Regulation of actin cytoskeleton_Homo sapiens_hsa048100.73246881
75Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73109225
76Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.72683466
77Viral myocarditis_Homo sapiens_hsa054160.72632217
78Non-small cell lung cancer_Homo sapiens_hsa052230.72434295
79Pancreatic secretion_Homo sapiens_hsa049720.72058300
80Butanoate metabolism_Homo sapiens_hsa006500.71691980
81Proteoglycans in cancer_Homo sapiens_hsa052050.70490802
82Pyruvate metabolism_Homo sapiens_hsa006200.69609084
83Long-term depression_Homo sapiens_hsa047300.69582522
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.69270262
85Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.67701079
86Ovarian steroidogenesis_Homo sapiens_hsa049130.66476471
87Glycosaminoglycan degradation_Homo sapiens_hsa005310.66183145
88Neurotrophin signaling pathway_Homo sapiens_hsa047220.66174446
89Nitrogen metabolism_Homo sapiens_hsa009100.66106421
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64825426
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64754783
92Chronic myeloid leukemia_Homo sapiens_hsa052200.62213547
93Melanogenesis_Homo sapiens_hsa049160.60540088
94Phosphatidylinositol signaling system_Homo sapiens_hsa040700.59761281
95Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.59744390
96Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.59204680
97Glioma_Homo sapiens_hsa052140.58006244
98Small cell lung cancer_Homo sapiens_hsa052220.56862301
99Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.56727452
100Tight junction_Homo sapiens_hsa045300.56674091
101Phospholipase D signaling pathway_Homo sapiens_hsa040720.55463418
102Inositol phosphate metabolism_Homo sapiens_hsa005620.55240915
103Hippo signaling pathway_Homo sapiens_hsa043900.54825532
104Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53329165
105MAPK signaling pathway_Homo sapiens_hsa040100.51886264
106Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.50782938
107Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50250449
108Choline metabolism in cancer_Homo sapiens_hsa052310.49926229
109Focal adhesion_Homo sapiens_hsa045100.49421642
110VEGF signaling pathway_Homo sapiens_hsa043700.49076770
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.48780012
112Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.48531484
113AMPK signaling pathway_Homo sapiens_hsa041520.48383447
114Vibrio cholerae infection_Homo sapiens_hsa051100.46489489
115Axon guidance_Homo sapiens_hsa043600.45988854
116ErbB signaling pathway_Homo sapiens_hsa040120.45651495
117PPAR signaling pathway_Homo sapiens_hsa033200.45635585
118Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45045248
119HIF-1 signaling pathway_Homo sapiens_hsa040660.44592330
120Leukocyte transendothelial migration_Homo sapiens_hsa046700.43668908
121FoxO signaling pathway_Homo sapiens_hsa040680.43106379
122Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.42786396
123Fatty acid elongation_Homo sapiens_hsa000620.42446149
124Melanoma_Homo sapiens_hsa052180.41987834
125Amoebiasis_Homo sapiens_hsa051460.41256473
126Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39809521
127Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39737720
128Starch and sucrose metabolism_Homo sapiens_hsa005000.37824783
129Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.37540297
130Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36917690
131Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.36624591
132Bile secretion_Homo sapiens_hsa049760.36501143
133Biosynthesis of amino acids_Homo sapiens_hsa012300.36049754
134mTOR signaling pathway_Homo sapiens_hsa041500.35638639
135Renal cell carcinoma_Homo sapiens_hsa052110.35259076
136Adherens junction_Homo sapiens_hsa045200.34634835
137Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34452248
138Fructose and mannose metabolism_Homo sapiens_hsa000510.33855699
139Glycerophospholipid metabolism_Homo sapiens_hsa005640.33441378
140Endocytosis_Homo sapiens_hsa041440.33014380
141Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.32892960
142Rap1 signaling pathway_Homo sapiens_hsa040150.31410981
143Tyrosine metabolism_Homo sapiens_hsa003500.30931696
144Basal cell carcinoma_Homo sapiens_hsa052170.27822885

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