DOLK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene catalyzes the CTP-mediated phosphorylation of dolichol, and is involved in the synthesis of Dol-P-Man, which is an essential glycosyl carrier lipid for C- and O-mannosylation, N- and O-linked glycosylation of proteins, and for the biosynthesis of glycosyl phosphatidylinositol anchors in endoplasmic reticulum. Mutations in this gene are associated with dolichol kinase deficiency. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein maturation by protein folding (GO:0022417)5.00993428
2NADH metabolic process (GO:0006734)4.96500265
3low-density lipoprotein particle clearance (GO:0034383)4.71313981
4tricarboxylic acid cycle (GO:0006099)4.65436232
5biotin metabolic process (GO:0006768)4.63314931
6valine metabolic process (GO:0006573)4.52203816
7regulation of sequestering of triglyceride (GO:0010889)4.35719451
8branched-chain amino acid catabolic process (GO:0009083)4.33884330
9fatty acid beta-oxidation (GO:0006635)4.31992119
10alpha-linolenic acid metabolic process (GO:0036109)4.27307119
11thioester biosynthetic process (GO:0035384)4.09575894
12acyl-CoA biosynthetic process (GO:0071616)4.09575894
13succinate metabolic process (GO:0006105)4.03901378
14fatty-acyl-CoA metabolic process (GO:0035337)3.92002294
15fatty acid catabolic process (GO:0009062)3.91269993
16acetyl-CoA metabolic process (GO:0006084)3.89152904
17branched-chain amino acid metabolic process (GO:0009081)3.89034750
18fatty-acyl-CoA biosynthetic process (GO:0046949)3.88533139
19proteasome assembly (GO:0043248)3.86873924
20oxaloacetate metabolic process (GO:0006107)3.86377408
21fatty acid oxidation (GO:0019395)3.85761450
22lipid oxidation (GO:0034440)3.83045674
23fatty acid transmembrane transport (GO:1902001)3.80983827
24long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.78652215
25positive regulation of fatty acid oxidation (GO:0046321)3.75507719
26carnitine shuttle (GO:0006853)3.75274172
27triglyceride catabolic process (GO:0019433)3.74570515
28positive regulation of fatty acid beta-oxidation (GO:0032000)3.71302816
29proline biosynthetic process (GO:0006561)3.64880321
30regulation of fatty acid oxidation (GO:0046320)3.63012866
31long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.61155058
32tricarboxylic acid metabolic process (GO:0072350)3.54099644
33lysine metabolic process (GO:0006553)3.53950019
34lysine catabolic process (GO:0006554)3.53950019
35triglyceride biosynthetic process (GO:0019432)3.53417321
36maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.52093208
37neutral lipid catabolic process (GO:0046461)3.50960216
38acylglycerol catabolic process (GO:0046464)3.50960216
39protein retention in ER lumen (GO:0006621)3.49149267
40lipid particle organization (GO:0034389)3.47929331
41erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.47683211
42L-phenylalanine metabolic process (GO:0006558)3.47683211
43acyl-CoA metabolic process (GO:0006637)3.44321532
44thioester metabolic process (GO:0035383)3.44321532
45erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.42811782
46L-phenylalanine catabolic process (GO:0006559)3.42811782
47neutral lipid biosynthetic process (GO:0046460)3.37403841
48acylglycerol biosynthetic process (GO:0046463)3.37403841
49fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.37268569
50negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.33906306
51fatty acid homeostasis (GO:0055089)3.33337534
52very long-chain fatty acid metabolic process (GO:0000038)3.25860815
53retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.25589015
54monocarboxylic acid catabolic process (GO:0072329)3.24958072
55sulfur amino acid catabolic process (GO:0000098)3.24719756
56negative regulation of ligase activity (GO:0051352)3.23184814
57negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.23184814
58negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.21444589
59serine family amino acid biosynthetic process (GO:0009070)3.20200714
60brown fat cell differentiation (GO:0050873)3.18219031
61establishment of integrated proviral latency (GO:0075713)3.11121785
62regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.10033633
63regulation of fatty acid beta-oxidation (GO:0031998)3.09567524
64plasma lipoprotein particle clearance (GO:0034381)3.07738256
65mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.05558872
66anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.04707634
67positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.03552142
68coenzyme A metabolic process (GO:0015936)3.03462045
69L-serine metabolic process (GO:0006563)2.98047188
702-oxoglutarate metabolic process (GO:0006103)2.96643333
71mitotic nuclear envelope reassembly (GO:0007084)2.94801893
72nuclear envelope reassembly (GO:0031468)2.94801893
73cellular response to leptin stimulus (GO:0044320)2.93936715
74respiratory electron transport chain (GO:0022904)2.93254334
75mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.92486105
76regulation of cellular amino acid metabolic process (GO:0006521)2.91620156
77peptidyl-histidine modification (GO:0018202)2.91127139
78proline metabolic process (GO:0006560)2.90862199
79regulation of triglyceride biosynthetic process (GO:0010866)2.89942468
80coenzyme catabolic process (GO:0009109)2.89870990
81aspartate family amino acid catabolic process (GO:0009068)2.89854935
82negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.88594667
83cysteine metabolic process (GO:0006534)2.88581590
84electron transport chain (GO:0022900)2.88397711
85establishment of viral latency (GO:0019043)2.88050238
86peroxisome fission (GO:0016559)2.87828736
87regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.86236312
88short-chain fatty acid metabolic process (GO:0046459)2.86226939
89tRNA aminoacylation for protein translation (GO:0006418)2.84339480
90response to dietary excess (GO:0002021)2.84225972
91positive regulation of fatty acid metabolic process (GO:0045923)2.83928907
92Golgi transport vesicle coating (GO:0048200)2.83349652
93COPI coating of Golgi vesicle (GO:0048205)2.83349652
94regulation of acyl-CoA biosynthetic process (GO:0050812)2.83076196
95carnitine transmembrane transport (GO:1902603)2.82520579
96GDP-mannose metabolic process (GO:0019673)2.82183329
97acylglycerol homeostasis (GO:0055090)2.81081185
98triglyceride homeostasis (GO:0070328)2.81081185
99COPII vesicle coating (GO:0048208)2.79295729
100mitochondrial fusion (GO:0008053)2.79203524
101response to leptin (GO:0044321)2.78998567
102triglyceride metabolic process (GO:0006641)2.78081117
103nucleobase-containing small molecule interconversion (GO:0015949)2.77905959
104glycerolipid catabolic process (GO:0046503)2.77838398
105NADPH regeneration (GO:0006740)2.77807098
106regulation of mitochondrial translation (GO:0070129)2.77526978
107cholesterol biosynthetic process (GO:0006695)2.76369559
108ventricular cardiac muscle cell development (GO:0055015)2.76359029
109alanine transport (GO:0032328)2.75778204
110triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.75090921
111L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.74262052
112deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.70715375
113coenzyme A biosynthetic process (GO:0015937)2.69962855
114purine ribonucleotide transport (GO:0015868)2.69878649
115tRNA aminoacylation (GO:0043039)2.69409162
116amino acid activation (GO:0043038)2.69409162
117organic acid catabolic process (GO:0016054)2.68134438
118carboxylic acid catabolic process (GO:0046395)2.68134438
119regulation of triglyceride catabolic process (GO:0010896)2.65884422
120regulation of cholesterol metabolic process (GO:0090181)2.65110412
121amino-acid betaine transport (GO:0015838)2.64483316
122carnitine transport (GO:0015879)2.64483316
123regulation of triglyceride metabolic process (GO:0090207)2.63759768
124regulation of coenzyme metabolic process (GO:0051196)2.63646579
125regulation of cofactor metabolic process (GO:0051193)2.63646579
126oxidative phosphorylation (GO:0006119)2.63635853
127cullin deneddylation (GO:0010388)2.62902386
128L-serine transport (GO:0015825)2.62258276
129sterol biosynthetic process (GO:0016126)2.61783781
1304-hydroxyproline metabolic process (GO:0019471)2.61554988
131white fat cell differentiation (GO:0050872)2.61422498
132acylglycerol metabolic process (GO:0006639)2.61218104
133neutral lipid metabolic process (GO:0006638)2.61039622
134positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.61018412
135CDP-diacylglycerol metabolic process (GO:0046341)2.60906945
136amyloid precursor protein catabolic process (GO:0042987)2.59913565
137pantothenate metabolic process (GO:0015939)2.59380675
138protein deneddylation (GO:0000338)2.58016393
139regulation of ubiquitin-protein transferase activity (GO:0051438)2.57536473
140cellular ketone body metabolic process (GO:0046950)2.55904720
141pentose-phosphate shunt (GO:0006098)2.54564945
142positive regulation of triglyceride metabolic process (GO:0090208)2.54315494
143DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.53836364
144positive regulation of lipid catabolic process (GO:0050996)2.53194405
145signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.52857662
146intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.52857662
147quinone biosynthetic process (GO:1901663)2.52095802
148de novo protein folding (GO:0006458)2.49734065
149signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.49066300
150signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.49066300
151signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.49066300
152signal transduction involved in DNA damage checkpoint (GO:0072422)2.48179858
153signal transduction involved in DNA integrity checkpoint (GO:0072401)2.48179858
154positive regulation of ligase activity (GO:0051351)2.47634358
155regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.47237810
156serine transport (GO:0032329)2.46825682
157regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.46808853
158protein targeting to mitochondrion (GO:0006626)2.46333511
159regulation of ligase activity (GO:0051340)2.46316481
160DNA strand elongation (GO:0022616)2.45799019
161negative regulation of mitochondrion organization (GO:0010823)2.45170716
162de novo posttranslational protein folding (GO:0051084)2.45169247
163pseudouridine synthesis (GO:0001522)2.45073745
164* dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.45027777
165DNA strand elongation involved in DNA replication (GO:0006271)2.43520262
166mitotic metaphase plate congression (GO:0007080)2.43201261
167signal transduction involved in cell cycle checkpoint (GO:0072395)2.43030049
168folic acid-containing compound biosynthetic process (GO:0009396)2.42981590
169monosaccharide biosynthetic process (GO:0046364)2.42189445
170telomere maintenance via semi-conservative replication (GO:0032201)2.39939964
171pteridine-containing compound biosynthetic process (GO:0042559)2.39912153
172L-methionine biosynthetic process (GO:0071265)2.39745613
173amino acid salvage (GO:0043102)2.39745613
174L-methionine salvage (GO:0071267)2.39745613
175cell adhesion mediated by integrin (GO:0033627)2.37089439
176regulation of mammary gland epithelial cell proliferation (GO:0033599)2.32246818
177rRNA transcription (GO:0009303)2.32101696
178regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.31811866
179nucleoside transmembrane transport (GO:1901642)2.30812270
180chaperone-mediated protein transport (GO:0072321)2.30635713
181protein complex localization (GO:0031503)2.30448646
182gluconeogenesis (GO:0006094)2.30382619
183glucose catabolic process (GO:0006007)2.29477988
184tetrahydrofolate metabolic process (GO:0046653)2.27816288
185nucleotide-sugar biosynthetic process (GO:0009226)2.27502950
186termination of RNA polymerase III transcription (GO:0006386)2.27052649
187transcription elongation from RNA polymerase III promoter (GO:0006385)2.27052649
188hexose biosynthetic process (GO:0019319)2.26529004
189ribosome assembly (GO:0042255)2.26302045
190glycine metabolic process (GO:0006544)2.26049965
191folic acid-containing compound metabolic process (GO:0006760)2.25865803
192pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.24225997
193pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.24198287

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse8.69241603
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.15905181
3TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.74295828
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.80950673
5RXR_22158963_ChIP-Seq_LIVER_Mouse3.59136722
6CLOCK_20551151_ChIP-Seq_293T_Human3.44646037
7* MYC_18555785_ChIP-Seq_MESCs_Mouse3.19907633
8MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.96684460
9PPARA_22158963_ChIP-Seq_LIVER_Mouse2.90897943
10E2F7_22180533_ChIP-Seq_HELA_Human2.83030311
11CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.81474135
12ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.75187788
13TRIM28_21343339_ChIP-Seq_HEK293_Human2.57917843
14PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.57598337
15LXR_22158963_ChIP-Seq_LIVER_Mouse2.53505995
16TP63_17297297_ChIP-ChIP_HaCaT_Human2.38244715
17* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.34948327
18RARG_19884340_ChIP-ChIP_MEFs_Mouse2.33665856
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.32867851
20FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.31399204
21* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.27755702
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.23072553
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.22596507
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.16933697
25KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.14144395
26XRN2_22483619_ChIP-Seq_HELA_Human2.10276925
27DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.04636262
28FOXM1_23109430_ChIP-Seq_U2OS_Human2.01082739
29CREB1_15753290_ChIP-ChIP_HEK293T_Human1.97856623
30AR_21909140_ChIP-Seq_LNCAP_Human1.96635132
31CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.96567852
32PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.94498871
33MYC_19079543_ChIP-ChIP_MESCs_Mouse1.92556124
34SRF_21415370_ChIP-Seq_HL-1_Mouse1.87457683
35ZNF263_19887448_ChIP-Seq_K562_Human1.83213930
36MYCN_18555785_ChIP-Seq_MESCs_Mouse1.81398565
37ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.79260793
38CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.78871263
39RBPJ_22232070_ChIP-Seq_NCS_Mouse1.75454478
40POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.75190179
41EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.74960048
42NANOG_18555785_ChIP-Seq_MESCs_Mouse1.72511001
43EGR1_23403033_ChIP-Seq_LIVER_Mouse1.66533002
44YY1_21170310_ChIP-Seq_MESCs_Mouse1.62709543
45TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.59005878
46GABP_17652178_ChIP-ChIP_JURKAT_Human1.55943750
47* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.54710216
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.53876763
49KLF4_18555785_ChIP-Seq_MESCs_Mouse1.50547461
50DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.48830059
51ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.47936474
52ELF1_17652178_ChIP-ChIP_JURKAT_Human1.47141175
53ETS1_20019798_ChIP-Seq_JURKAT_Human1.46594473
54PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.45041203
55CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.44983614
56NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.41732264
57KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.41678921
58TTF2_22483619_ChIP-Seq_HELA_Human1.41167159
59* TFEB_21752829_ChIP-Seq_HELA_Human1.41153844
60CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.38141627
61HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.33804060
62SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.28742274
63SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.27495697
64KDM5A_27292631_Chip-Seq_BREAST_Human1.26747164
65EOMES_21245162_ChIP-Seq_HESCs_Human1.25663198
66HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.25014666
67* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.23677207
68CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.22946097
69TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.21837235
70HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.20276976
71PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.19617836
72MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.19540179
73CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.18673390
74* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.18244747
75SOX17_20123909_ChIP-Seq_XEN_Mouse1.17937850
76SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.17762033
77FOXP3_21729870_ChIP-Seq_TREG_Human1.16891288
78ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.16054333
79ELK3_25401928_ChIP-Seq_HUVEC_Human1.15964485
80TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.15438650
81ESR1_15608294_ChIP-ChIP_MCF-7_Human1.14047271
82CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.13827510
83ERG_21242973_ChIP-ChIP_JURKAT_Human1.13710332
84E2F4_17652178_ChIP-ChIP_JURKAT_Human1.11694227
85* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11507451
86SRY_22984422_ChIP-ChIP_TESTIS_Rat1.10769853
87STAT3_1855785_ChIP-Seq_MESCs_Mouse1.10440938
88RACK7_27058665_Chip-Seq_MCF-7_Human1.09893022
89* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.09582990
90E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09567698
91ERG_20887958_ChIP-Seq_HPC-7_Mouse1.07710156
92HIF1A_21447827_ChIP-Seq_MCF-7_Human1.07433047
93TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.06146266
94EED_16625203_ChIP-ChIP_MESCs_Mouse1.04916490
95NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.03858496
96E2F1_21310950_ChIP-Seq_MCF-7_Human1.03842192
97ATF3_27146783_Chip-Seq_COLON_Human1.02325972
98SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.01996644
99ELK1_19687146_ChIP-ChIP_HELA_Human1.01155804
100* VDR_23849224_ChIP-Seq_CD4+_Human1.00778729
101CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.00674113
102POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.00648010
103PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.00574400
104RAD21_21589869_ChIP-Seq_MESCs_Mouse0.99342864
105HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.99330524
106MYC_18358816_ChIP-ChIP_MESCs_Mouse0.96171450
107THAP11_20581084_ChIP-Seq_MESCs_Mouse0.96095155
108BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.95062504
109CTCF_18555785_ChIP-Seq_MESCs_Mouse0.94035336
110TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.93692440
111GABP_19822575_ChIP-Seq_HepG2_Human0.93531324
112SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.93000228
113NR3C1_23031785_ChIP-Seq_PC12_Mouse0.92453428
114SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.91935208
115SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.90547391
116TET1_21451524_ChIP-Seq_MESCs_Mouse0.90394533
117SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.89207373
118TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88995230
119* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.87545033
120MTF2_20144788_ChIP-Seq_MESCs_Mouse0.86117775
121ZNF274_21170338_ChIP-Seq_K562_Hela0.85848086
122TBX5_21415370_ChIP-Seq_HL-1_Mouse0.85302616
123SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.84668825
124GATA4_21415370_ChIP-Seq_HL-1_Mouse0.82716092
125NRF2_20460467_ChIP-Seq_MEFs_Mouse0.82669664
126NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.82669664
127PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82163287
128REST_18959480_ChIP-ChIP_MESCs_Mouse0.81221335
129CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.80957303
130EST1_17652178_ChIP-ChIP_JURKAT_Human0.79483973
131SMC4_20622854_ChIP-Seq_HELA_Human0.79381067
132STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.78218259
133ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.77543977
134EP300_21415370_ChIP-Seq_HL-1_Mouse0.77202260
135HTT_18923047_ChIP-ChIP_STHdh_Human0.76667175
136ELK1_22589737_ChIP-Seq_MCF10A_Human0.76130940
137DCP1A_22483619_ChIP-Seq_HELA_Human0.74161855
138CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.73806529
139THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.73539615
140NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.73376249
141SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.71820117
142SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.71429994
143MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.71351265
144NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.70813938
145FOXH1_21741376_ChIP-Seq_ESCs_Human0.69289104
146CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.68283155
147YY1_22570637_ChIP-Seq_MALME-3M_Human0.68198032
148CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.67812599
149PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.67734245
150GBX2_23144817_ChIP-Seq_PC3_Human0.66827711
151SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.66469390
152SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.65358206
153TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.65120600
154OCT4_20526341_ChIP-Seq_ESCs_Human0.64529960
155GATA2_21666600_ChIP-Seq_HMVEC_Human0.64493286
156RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.64295339
157PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human0.63980437
158MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.63838154

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.79308798
2MP0008438_abnormal_cutaneous_collagen4.41370650
3MP0005670_abnormal_white_adipose3.74145132
4MP0004130_abnormal_muscle_cell3.46541358
5MP0000013_abnormal_adipose_tissue3.18295265
6MP0003195_calcinosis3.12528259
7MP0005257_abnormal_intraocular_pressure3.00918938
8MP0002139_abnormal_hepatobiliary_system3.00436644
9MP0003941_abnormal_skin_development2.96860060
10MP0003806_abnormal_nucleotide_metabolis2.91215750
11MP0005365_abnormal_bile_salt2.84753845
12MP0000003_abnormal_adipose_tissue2.71021863
13MP0005666_abnormal_adipose_tissue2.59768322
14MP0005275_abnormal_skin_tensile2.53476876
15MP0010030_abnormal_orbit_morphology2.52444482
16MP0010329_abnormal_lipoprotein_level2.48161476
17MP0008789_abnormal_olfactory_epithelium2.47979694
18MP0005375_adipose_tissue_phenotype2.44631436
19MP0003693_abnormal_embryo_hatching2.36524931
20MP0004233_abnormal_muscle_weight2.32001826
21MP0005360_urolithiasis2.26502909
22MP0008932_abnormal_embryonic_tissue2.24005769
23MP0004957_abnormal_blastocyst_morpholog2.16957966
24MP0005623_abnormal_meninges_morphology2.09000768
25MP0003111_abnormal_nucleus_morphology2.05241844
26MP0004185_abnormal_adipocyte_glucose2.04804962
27MP0005499_abnormal_olfactory_system2.04194854
28MP0005394_taste/olfaction_phenotype2.04194854
29MP0000751_myopathy1.98133245
30MP0002118_abnormal_lipid_homeostasis1.95748909
31MP0003656_abnormal_erythrocyte_physiolo1.94123221
32MP0006036_abnormal_mitochondrial_physio1.90502207
33MP0009840_abnormal_foam_cell1.90210384
34MP0002971_abnormal_brown_adipose1.79561790
35MP0005503_abnormal_tendon_morphology1.76803425
36MP0003566_abnormal_cell_adhesion1.73986440
37MP0005332_abnormal_amino_acid1.68417818
38MP0000749_muscle_degeneration1.66725963
39MP0010352_gastrointestinal_tract_polyps1.66487682
40MP0002876_abnormal_thyroid_physiology1.65704713
41MP0004147_increased_porphyrin_level1.65197177
42MP0001661_extended_life_span1.62351889
43MP0000537_abnormal_urethra_morphology1.61927018
44MP0003329_amyloid_beta_deposits1.61075374
45MP0009053_abnormal_anal_canal1.60009503
46MP0008260_abnormal_autophagy1.59935358
47MP0003077_abnormal_cell_cycle1.57965114
48MP0005501_abnormal_skin_physiology1.57836785
49MP0000747_muscle_weakness1.53624332
50MP0010094_abnormal_chromosome_stability1.51993705
51MP0009697_abnormal_copulation1.50347792
52MP0002060_abnormal_skin_morphology1.49912202
53MP0004215_abnormal_myocardial_fiber1.47532601
54MP0001730_embryonic_growth_arrest1.47332248
55MP0005085_abnormal_gallbladder_physiolo1.46218217
56MP0002877_abnormal_melanocyte_morpholog1.46195813
57MP0004036_abnormal_muscle_relaxation1.42970324
58MP0009780_abnormal_chondrocyte_physiolo1.41452698
59MP0005535_abnormal_body_temperature1.41282679
60MP0001849_ear_inflammation1.40164862
61MP0005451_abnormal_body_composition1.39686250
62MP0005058_abnormal_lysosome_morphology1.38662029
63MP0002638_abnormal_pupillary_reflex1.35747559
64MP0003191_abnormal_cellular_cholesterol1.34759788
65MP0005334_abnormal_fat_pad1.34671369
66MP0001727_abnormal_embryo_implantation1.33163184
67MP0002078_abnormal_glucose_homeostasis1.32849490
68MP0003646_muscle_fatigue1.31976840
69MP0002796_impaired_skin_barrier1.31740055
70MP0005584_abnormal_enzyme/coenzyme_acti1.30464101
71MP0003718_maternal_effect1.30384246
72MP0002970_abnormal_white_adipose1.27264984
73MP0003705_abnormal_hypodermis_morpholog1.26924898
74MP0010368_abnormal_lymphatic_system1.26742373
75MP0008007_abnormal_cellular_replicative1.24868127
76MP0003786_premature_aging1.22330758
77MP0005448_abnormal_energy_balance1.21353657
78MP0006035_abnormal_mitochondrial_morpho1.20767895
79MP0005319_abnormal_enzyme/_coenzyme1.20192256
80MP0005330_cardiomyopathy1.20186417
81MP0003315_abnormal_perineum_morphology1.19984660
82MP0000609_abnormal_liver_physiology1.19981730
83MP0000750_abnormal_muscle_regeneration1.19678820
84MP0002697_abnormal_eye_size1.19669594
85MP0008058_abnormal_DNA_repair1.19380290
86MP0004272_abnormal_basement_membrane1.18655627
87MP0002233_abnormal_nose_morphology1.17908517
88MP0003942_abnormal_urinary_system1.16831484
89MP0009115_abnormal_fat_cell1.16256538
90MP0001243_abnormal_dermal_layer1.15706845
91MP0002269_muscular_atrophy1.15383627
92MP0003186_abnormal_redox_activity1.15265505
93MP0005367_renal/urinary_system_phenotyp1.15105410
94MP0000516_abnormal_urinary_system1.15105410
95MP0001542_abnormal_bone_strength1.14660969
96MP0001764_abnormal_homeostasis1.13156495
97MP0004084_abnormal_cardiac_muscle1.13041761
98MP0009672_abnormal_birth_weight1.11138215
99MP0000762_abnormal_tongue_morphology1.10481991
100MP0002090_abnormal_vision1.09777342
101MP0003252_abnormal_bile_duct1.08483974
102MP0000049_abnormal_middle_ear1.07444705
103MP0002108_abnormal_muscle_morphology1.06000811
104MP0000759_abnormal_skeletal_muscle1.04247050
105MP0003959_abnormal_lean_body1.03500239
106MP0005197_abnormal_uvea_morphology1.03009546
107MP0003385_abnormal_body_wall1.02813247
108MP0002080_prenatal_lethality1.02691369
109MP0005380_embryogenesis_phenotype1.01077694
110MP0001672_abnormal_embryogenesis/_devel1.01077694
111MP0002909_abnormal_adrenal_gland1.00153665
112MP0003279_aneurysm0.99922067
113MP0001529_abnormal_vocalization0.99701502
114MP0005452_abnormal_adipose_tissue0.98312167
115MP0008775_abnormal_heart_ventricle0.97658983
116MP0003937_abnormal_limbs/digits/tail_de0.97616961
117MP0006138_congestive_heart_failure0.97259439
118MP0000579_abnormal_nail_morphology0.97052146
119MP0002092_abnormal_eye_morphology0.96713071
120MP0000678_abnormal_parathyroid_gland0.95914150
121MP0005508_abnormal_skeleton_morphology0.95521207
122MP0003453_abnormal_keratinocyte_physiol0.95420893
123MP0002085_abnormal_embryonic_tissue0.95040216
124MP0000604_amyloidosis0.94757760
125MP0002254_reproductive_system_inflammat0.93009974
126MP0001915_intracranial_hemorrhage0.91890168
127MP0000350_abnormal_cell_proliferation0.91460324
128MP0008875_abnormal_xenobiotic_pharmacok0.90860922
129MP0009250_abnormal_appendicular_skeleto0.90789408
130MP0003984_embryonic_growth_retardation0.90551062
131MP0003755_abnormal_palate_morphology0.90535902
132MP0005620_abnormal_muscle_contractility0.90140125
133MP0003953_abnormal_hormone_level0.89015219
134MP0003690_abnormal_glial_cell0.88637688
135MP0010771_integument_phenotype0.88623925
136MP0004858_abnormal_nervous_system0.86722450
137MP0000230_abnormal_systemic_arterial0.86632067
138MP0001697_abnormal_embryo_size0.85746327
139MP0002111_abnormal_tail_morphology0.85383687
140MP0005408_hypopigmentation0.84159325
141MP0000467_abnormal_esophagus_morphology0.82862278
142MP0000462_abnormal_digestive_system0.82850570
143MP0001544_abnormal_cardiovascular_syste0.82635826
144MP0005385_cardiovascular_system_phenoty0.82635826
145MP0003011_delayed_dark_adaptation0.82252586
146MP0001216_abnormal_epidermal_layer0.81346738
147MP0005193_abnormal_anterior_eye0.80764779
148MP0003123_paternal_imprinting0.80533975
149MP0000534_abnormal_ureter_morphology0.80262189
150MP0005084_abnormal_gallbladder_morpholo0.80244854
151MP0002088_abnormal_embryonic_growth/wei0.80053461
152MP0001666_abnormal_nutrient_absorption0.79845020
153MP0006054_spinal_hemorrhage0.79496172
154MP0004019_abnormal_vitamin_homeostasis0.78889463
155MP0005636_abnormal_mineral_homeostasis0.77775985
156MP0002084_abnormal_developmental_patter0.77447777
157MP0005369_muscle_phenotype0.77375996
158MP0006276_abnormal_autonomic_nervous0.77338287
159MP0005220_abnormal_exocrine_pancreas0.76845439
160MP0005384_cellular_phenotype0.76844264
161MP0009643_abnormal_urine_homeostasis0.76551198
162MP0001881_abnormal_mammary_gland0.76183690
163MP0004043_abnormal_pH_regulation0.74413553
164MP0002736_abnormal_nociception_after0.72971674
165MP0008961_abnormal_basal_metabolism0.72696263
166MP0004145_abnormal_muscle_electrophysio0.72318569
167MP0009384_cardiac_valve_regurgitation0.71203526
168MP0005083_abnormal_biliary_tract0.69154241
169MP0003137_abnormal_impulse_conducting0.68964163
170MP0004087_abnormal_muscle_fiber0.68668096
171MP0001984_abnormal_olfaction0.68114122
172MP0001299_abnormal_eye_distance/0.65645344
173MP0000358_abnormal_cell_content/0.65572217
174MP0002972_abnormal_cardiac_muscle0.64994147
175MP0004270_analgesia0.63944418

Predicted human phenotypes

RankGene SetZ-score
1Hepatic necrosis (HP:0002605)3.98227469
2Oligomenorrhea (HP:0000876)3.89989182
3Hypoglycemic coma (HP:0001325)3.68502036
4Hyperglycinuria (HP:0003108)3.63562123
5Hepatocellular necrosis (HP:0001404)3.62622858
6Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.47902986
7Hyperlipoproteinemia (HP:0010980)3.44234370
8Abnormality of fatty-acid metabolism (HP:0004359)3.37541519
9Abnormal mitochondria in muscle tissue (HP:0008316)3.37130239
10Abnormality of serine family amino acid metabolism (HP:0010894)3.36772413
11Abnormality of glycine metabolism (HP:0010895)3.36772413
12Short nail (HP:0001799)3.30586605
13Acute encephalopathy (HP:0006846)3.25963265
14Acute necrotizing encephalopathy (HP:0006965)3.21605880
15Myoglobinuria (HP:0002913)3.19156842
16Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.19040058
17Decreased activity of mitochondrial respiratory chain (HP:0008972)3.19040058
18Ketosis (HP:0001946)3.18954548
19Ketoacidosis (HP:0001993)3.17696724
20Hyperammonemia (HP:0001987)3.00113361
21Cerebral edema (HP:0002181)2.99061394
22Hyperglycinemia (HP:0002154)2.99058156
23Mitochondrial inheritance (HP:0001427)2.91305132
24Lactic acidosis (HP:0003128)2.90462155
25Pheochromocytoma (HP:0002666)2.88552249
26Xanthomatosis (HP:0000991)2.88217023
27Dicarboxylic aciduria (HP:0003215)2.87231178
28Abnormality of dicarboxylic acid metabolism (HP:0010995)2.87231178
29Abnormality of glycolysis (HP:0004366)2.86370188
30Increased serum pyruvate (HP:0003542)2.86370188
31Abnormality of glycolipid metabolism (HP:0010969)2.81509383
32Abnormality of liposaccharide metabolism (HP:0010968)2.81509383
33Abnormality of glycosphingolipid metabolism (HP:0004343)2.81509383
34Neuroendocrine neoplasm (HP:0100634)2.74421566
35Microretrognathia (HP:0000308)2.73924934
36Brushfield spots (HP:0001088)2.72880308
37Abnormality of aromatic amino acid family metabolism (HP:0004338)2.72374668
38Progressive macrocephaly (HP:0004481)2.72090661
39Reduced antithrombin III activity (HP:0001976)2.66547923
40Increased CSF lactate (HP:0002490)2.66443928
41Ragged-red muscle fibers (HP:0003200)2.59516950
42Increased muscle lipid content (HP:0009058)2.58836883
43Myocardial infarction (HP:0001658)2.58017581
44Protrusio acetabuli (HP:0003179)2.55702034
45Epiphyseal stippling (HP:0010655)2.54883568
46Intrahepatic cholestasis (HP:0001406)2.49497776
47Type I transferrin isoform profile (HP:0003642)2.47992306
48Cholecystitis (HP:0001082)2.46367679
49Abnormal gallbladder physiology (HP:0012438)2.46367679
50Abnormality of dentin (HP:0010299)2.45273816
51Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.45263760
52Abnormality of alanine metabolism (HP:0010916)2.45263760
53Hyperalaninemia (HP:0003348)2.45263760
54Premature rupture of membranes (HP:0001788)2.44937261
55Hydroureter (HP:0000072)2.44687541
56Abnormality of the distal phalanges of the toes (HP:0010182)2.40720100
57Rhabdomyolysis (HP:0003201)2.39665614
58* Abnormal protein glycosylation (HP:0012346)2.39541107
59* Abnormal glycosylation (HP:0012345)2.39541107
60* Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.39541107
61* Abnormal protein N-linked glycosylation (HP:0012347)2.39541107
62Lethargy (HP:0001254)2.39410253
63Methylmalonic aciduria (HP:0012120)2.36208187
64Rough bone trabeculation (HP:0100670)2.35202243
65Ankle contracture (HP:0006466)2.33139048
66Prolonged neonatal jaundice (HP:0006579)2.32636978
67Hand muscle atrophy (HP:0009130)2.32174042
68Hypokinesia (HP:0002375)2.31477718
69Microvesicular hepatic steatosis (HP:0001414)2.27939880
70Respiratory failure (HP:0002878)2.27460557
71Progressive muscle weakness (HP:0003323)2.25838091
72Acanthosis nigricans (HP:0000956)2.24399958
73Upper limb muscle weakness (HP:0003484)2.22364463
74Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.20862067
75Abnormality of the intrinsic pathway (HP:0010989)2.20335554
76Upper limb amyotrophy (HP:0009129)2.19373476
77Distal upper limb amyotrophy (HP:0007149)2.19373476
78Cortical dysplasia (HP:0002539)2.19159874
79Hypoglycemic seizures (HP:0002173)2.18433198
80Difficulty running (HP:0009046)2.16150288
81Generalized aminoaciduria (HP:0002909)2.15043323
82CNS demyelination (HP:0007305)2.13620058
83Hypoalphalipoproteinemia (HP:0003233)2.11860337
84Insulin-resistant diabetes mellitus (HP:0000831)2.11547148
85Testicular atrophy (HP:0000029)2.10875951
86Nausea (HP:0002018)2.10736999
87Palpitations (HP:0001962)2.10509389
88Trismus (HP:0000211)2.08496840
89Calf muscle hypertrophy (HP:0008981)2.07692987
90Vomiting (HP:0002013)2.07511127
91Myotonia (HP:0002486)2.06941059
92Complement deficiency (HP:0004431)2.06809523
93Abnormality of serum amino acid levels (HP:0003112)2.06427560
94Achilles tendon contracture (HP:0001771)2.06427513
95Biconcave vertebral bodies (HP:0004586)2.06326517
96Hyperinsulinemic hypoglycemia (HP:0000825)2.05286301
97Muscle hypertrophy of the lower extremities (HP:0008968)2.05102287
98Gout (HP:0001997)2.04395214
99Increased serum lactate (HP:0002151)2.04379202
100Spinal rigidity (HP:0003306)2.03234644
101Abnormality of the umbilical cord (HP:0010881)2.02897190
102Multiple enchondromatosis (HP:0005701)2.02615523
103Poor head control (HP:0002421)2.01586839
104Septate vagina (HP:0001153)2.01034360
105Vertebral compression fractures (HP:0002953)2.00205415
106Hypertriglyceridemia (HP:0002155)1.99951777
107Abnormal cartilage morphology (HP:0002763)1.98857362
108Atrophic scars (HP:0001075)1.97436991
109Selective tooth agenesis (HP:0001592)1.97419305
110Abnormality of carpal bone ossification (HP:0006257)1.94461749
111Cervical subluxation (HP:0003308)1.93002042
112Vaginal fistula (HP:0004320)1.92891257
113Abnormality of proline metabolism (HP:0010907)1.92512345
114Hydroxyprolinuria (HP:0003080)1.92512345
115Muscle stiffness (HP:0003552)1.91958408
116Exercise intolerance (HP:0003546)1.91922684
117Aplasia/Hypoplasia of the sacrum (HP:0008517)1.91617843
118Vacuolated lymphocytes (HP:0001922)1.90387512
119Hypolipoproteinemia (HP:0010981)1.89633778
120Muscle fiber splitting (HP:0003555)1.88123428
121Epidermoid cyst (HP:0200040)1.87304218
122Poor suck (HP:0002033)1.87164199
123Hypoplastic left heart (HP:0004383)1.86753049
124Sparse lateral eyebrow (HP:0005338)1.85876185
125Exercise-induced myalgia (HP:0003738)1.85447808
126Insulin resistance (HP:0000855)1.85253961
127Broad distal phalanx of finger (HP:0009836)1.85158365
128Abnormal trabecular bone morphology (HP:0100671)1.85055962
129Abnormalities of placenta or umbilical cord (HP:0001194)1.84188042
130Hyperglycemia (HP:0003074)1.83722661
131Deep venous thrombosis (HP:0002625)1.83169813
132Abnormality of the Achilles tendon (HP:0005109)1.82736963
133Colon cancer (HP:0003003)1.82303753
134Conjunctival hamartoma (HP:0100780)1.80700998
135Metabolic acidosis (HP:0001942)1.79675518
136Type II lissencephaly (HP:0007260)1.78864905
137Congenital glaucoma (HP:0001087)1.78313945
138Abnormal epiphyseal ossification (HP:0010656)1.77475535
139Late onset (HP:0003584)1.76597229
140Ulnar bowing (HP:0003031)1.75748536
141Emotional lability (HP:0000712)1.74887021
142Cerebral hemorrhage (HP:0001342)1.74260896
143Generalized amyotrophy (HP:0003700)1.73892479
144Hypoplasia of the capital femoral epiphysis (HP:0003090)1.72839771
145Increased intramyocellular lipid droplets (HP:0012240)1.72464395
146Spastic diplegia (HP:0001264)1.72194748
147Impaired pain sensation (HP:0007328)1.70986557
148Abnormality of pain sensation (HP:0010832)1.70986557
149Symptomatic seizures (HP:0011145)1.70898127
150Asymmetric septal hypertrophy (HP:0001670)1.70573839
151Abnormality of the phalanges of the hallux (HP:0010057)1.69880048
152Redundant skin (HP:0001582)1.69848724
153Generalized hypotonia (HP:0001290)1.69735838
154Microglossia (HP:0000171)1.69055381
155Retinal dysplasia (HP:0007973)1.68925437
156Methylmalonic acidemia (HP:0002912)1.67970871
157Acute hepatic failure (HP:0006554)1.66438641
158Secondary amenorrhea (HP:0000869)1.66203678
159Opisthotonus (HP:0002179)1.65710376
160Breech presentation (HP:0001623)1.65479771
161Entropion (HP:0000621)1.63521953
162Elbow flexion contracture (HP:0002987)1.60943157
163Hypoplastic pelvis (HP:0008839)1.60247942
164Facial cleft (HP:0002006)1.59571161
165Long toe (HP:0010511)1.58506825
166Abnormal delivery (HP:0001787)1.57733215
167Fasciculations (HP:0002380)1.55780664
168Long palpebral fissure (HP:0000637)1.55408628
169Abnormal gallbladder morphology (HP:0012437)1.54980584
170Abnormality of the gallbladder (HP:0005264)1.53481932

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.69497026
2TRIB34.06077087
3VRK23.63032663
4PBK3.36656112
5SMG13.18016735
6TESK13.16599628
7PHKG23.06458703
8PHKG13.06458703
9EPHA22.60000867
10SIK12.46041246
11LMTK22.38767826
12IRAK32.25343639
13PDK42.17199399
14PDK32.17199399
15MYLK2.15061174
16CASK2.06644641
17PAK41.95096701
18TAF11.94854129
19ERN11.92735510
20NEK11.84986245
21INSRR1.82794650
22TTK1.79100889
23AKT31.68237884
24TTN1.60155434
25BRSK11.59251721
26CAMK1D1.58851378
27FER1.57150217
28ABL21.51739290
29MUSK1.50247368
30LATS21.44390774
31TNK21.42902958
32AURKA1.38955149
33PDK21.38939966
34LIMK11.34574001
35ARAF1.33947198
36MET1.29698755
37TRIM281.28988260
38TSSK61.27587366
39CSNK1A1L1.26145224
40SRPK11.25981338
41ICK1.23978755
42PINK11.23463088
43NME21.22676310
44CDC71.17174313
45CAMKK21.16410347
46MAP2K41.15999633
47SCYL21.14362934
48STK161.10906175
49CAMK2G1.10120308
50CSNK1G11.09143497
51SGK2231.08652707
52SGK4941.08652707
53EIF2AK11.07851763
54PLK11.05523058
55MAP2K11.04888824
56PRKD31.04034424
57DAPK11.03603975
58BRAF1.02009418
59MINK11.01732968
60CDK71.01447796
61NTRK10.98022922
62MAP2K70.96545284
63DDR20.94314549
64FRK0.93475507
65BUB10.93196171
66PAK30.91881921
67TAOK20.89047206
68MAP3K40.88709284
69CAMK2D0.87131655
70MAP3K30.85300311
71AURKB0.83958226
72PLK30.83534152
73EPHA40.82702552
74PIK3CG0.82659464
75MAPKAPK50.81912055
76PIK3CA0.81881588
77PRKCI0.80436401
78GRK50.80316239
79MAP3K80.78913281
80TESK20.77876251
81STK38L0.76815409
82RPS6KA40.76564813
83CDK90.76381010
84PRKAA20.75859819
85CHEK20.75368639
86ILK0.74905116
87PDPK10.73833578
88MAP3K50.71804737
89DYRK20.71754118
90EPHB20.71393785
91MAPK120.71354868
92MAP3K60.70905457
93MST1R0.70669262
94PIM20.70002202
95TIE10.69752332
96ERBB40.69157506
97DAPK30.67996683
98MELK0.67471858
99PRKCE0.67233756
100CAMK1G0.66586295
101PRKCG0.66436892
102OBSCN0.65215115
103NTRK30.65141039
104CAMK2B0.62507467
105MAP3K110.60251733
106PTK2B0.59911217
107PDGFRA0.59911009
108VRK10.59347130
109PRKACG0.59103160
110WEE10.58855833
111MAP3K90.58373069
112CDK80.58117240
113MAP2K30.57558569
114DYRK30.57190172
115MAPK40.56755629
116AKT20.56401684
117EPHB10.53543135
118LATS10.52998522
119CHEK10.52934278
120KDR0.50895186
121PTK20.50827829
122CAMK2A0.50762664
123MAPK110.50413713
124SGK20.49876102
125MAP3K120.49402574
126PAK20.49308673
127CDK140.49243043
128PAK60.49197772
129PRKACA0.49169775
130ACVR1B0.47981344
131STK100.47950180
132PRKD10.46586298
133CLK10.46548168
134PRKAA10.44736086
135RIPK10.43601678
136PRKCZ0.43545572
137CSNK1G30.43385158
138EIF2AK30.43245688
139NME10.42876495
140PAK10.42643811
141CSNK1G20.41703377
142CDK50.39957378
143ROCK20.39081551
144CDK180.38648813
145CCNB10.38425103
146CDK150.38419848
147KSR10.37772167
148BMX0.37366707
149TAOK10.36564563
150CDK11A0.35721293
151DYRK1B0.35647754
152CSNK2A10.34613154
153FLT30.33569460
154GSK3A0.29444629

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.15285036
2Propanoate metabolism_Homo sapiens_hsa006403.49382746
3Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.15544645
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.88198911
5Fatty acid metabolism_Homo sapiens_hsa012122.83713099
6Fatty acid degradation_Homo sapiens_hsa000712.69020867
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.65977304
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.58608336
9PPAR signaling pathway_Homo sapiens_hsa033202.51353959
10Fatty acid elongation_Homo sapiens_hsa000622.43452667
11Pyruvate metabolism_Homo sapiens_hsa006202.29601866
12DNA replication_Homo sapiens_hsa030302.22405738
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.13803804
14Oxidative phosphorylation_Homo sapiens_hsa001902.09822984
15Fatty acid biosynthesis_Homo sapiens_hsa000612.07914311
16Carbon metabolism_Homo sapiens_hsa012002.07728230
17Peroxisome_Homo sapiens_hsa041462.02091238
18Butanoate metabolism_Homo sapiens_hsa006502.02091042
19Base excision repair_Homo sapiens_hsa034101.89812151
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.89678698
21Parkinsons disease_Homo sapiens_hsa050121.85478277
22Primary bile acid biosynthesis_Homo sapiens_hsa001201.76515716
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.73261102
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.72732609
25Vitamin B6 metabolism_Homo sapiens_hsa007501.67640324
26Mismatch repair_Homo sapiens_hsa034301.57073303
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.54976258
28Other glycan degradation_Homo sapiens_hsa005111.50855305
29Sulfur metabolism_Homo sapiens_hsa009201.50035139
30Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.49523043
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.49324583
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.48893365
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.48372405
34RNA polymerase_Homo sapiens_hsa030201.48301471
35Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.48001307
36Pyrimidine metabolism_Homo sapiens_hsa002401.47616392
37One carbon pool by folate_Homo sapiens_hsa006701.47329046
38Glycosaminoglycan degradation_Homo sapiens_hsa005311.44980214
39beta-Alanine metabolism_Homo sapiens_hsa004101.40318536
40Glycerolipid metabolism_Homo sapiens_hsa005611.37984644
41Fat digestion and absorption_Homo sapiens_hsa049751.35148872
42Alzheimers disease_Homo sapiens_hsa050101.34198378
43Biosynthesis of amino acids_Homo sapiens_hsa012301.33079182
44Cyanoamino acid metabolism_Homo sapiens_hsa004601.31401163
45Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.30275323
46Tryptophan metabolism_Homo sapiens_hsa003801.29943137
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.23933280
48Folate biosynthesis_Homo sapiens_hsa007901.23268599
49Nucleotide excision repair_Homo sapiens_hsa034201.17609691
50Sulfur relay system_Homo sapiens_hsa041221.14204703
51Huntingtons disease_Homo sapiens_hsa050161.07479776
52Caffeine metabolism_Homo sapiens_hsa002321.04008092
53Protein export_Homo sapiens_hsa030600.99673558
54Cell cycle_Homo sapiens_hsa041100.97905289
55Drug metabolism - other enzymes_Homo sapiens_hsa009830.94064075
56RNA transport_Homo sapiens_hsa030130.93422159
57Proteasome_Homo sapiens_hsa030500.92057273
58Arginine biosynthesis_Homo sapiens_hsa002200.88354664
59Pentose phosphate pathway_Homo sapiens_hsa000300.88337865
60Cysteine and methionine metabolism_Homo sapiens_hsa002700.87984549
61Vitamin digestion and absorption_Homo sapiens_hsa049770.87128529
62Adipocytokine signaling pathway_Homo sapiens_hsa049200.86318444
63Starch and sucrose metabolism_Homo sapiens_hsa005000.82787315
64Phenylalanine metabolism_Homo sapiens_hsa003600.82468828
65Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.81777842
66Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.79783499
67* Metabolic pathways_Homo sapiens_hsa011000.78567535
68Maturity onset diabetes of the young_Homo sapiens_hsa049500.77904677
69Arginine and proline metabolism_Homo sapiens_hsa003300.77575096
70Steroid biosynthesis_Homo sapiens_hsa001000.76732396
71Spliceosome_Homo sapiens_hsa030400.76604006
72Tyrosine metabolism_Homo sapiens_hsa003500.76167419
73p53 signaling pathway_Homo sapiens_hsa041150.76144506
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.73329094
75Nitrogen metabolism_Homo sapiens_hsa009100.72279961
76Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.72019636
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71913618
78Cardiac muscle contraction_Homo sapiens_hsa042600.70259617
79Selenocompound metabolism_Homo sapiens_hsa004500.69233203
80Glycerophospholipid metabolism_Homo sapiens_hsa005640.68326486
81Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.68288261
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.65479727
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65274379
84Bladder cancer_Homo sapiens_hsa052190.64848542
85Vibrio cholerae infection_Homo sapiens_hsa051100.62965976
86Non-homologous end-joining_Homo sapiens_hsa034500.62838636
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62226095
88Complement and coagulation cascades_Homo sapiens_hsa046100.61621828
89Glucagon signaling pathway_Homo sapiens_hsa049220.61440759
90Central carbon metabolism in cancer_Homo sapiens_hsa052300.60500235
91Fructose and mannose metabolism_Homo sapiens_hsa000510.60493424
92AMPK signaling pathway_Homo sapiens_hsa041520.60476448
93Sphingolipid metabolism_Homo sapiens_hsa006000.60351897
94Glutathione metabolism_Homo sapiens_hsa004800.59326003
95Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.59051962
96Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58678515
97Homologous recombination_Homo sapiens_hsa034400.56615281
98Insulin signaling pathway_Homo sapiens_hsa049100.56167928
99Basal cell carcinoma_Homo sapiens_hsa052170.55322264
100Ribosome_Homo sapiens_hsa030100.53921383
101Histidine metabolism_Homo sapiens_hsa003400.50974327
102Fanconi anemia pathway_Homo sapiens_hsa034600.49930965
103Linoleic acid metabolism_Homo sapiens_hsa005910.47186199
104Basal transcription factors_Homo sapiens_hsa030220.47116880
105Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45693732
106Galactose metabolism_Homo sapiens_hsa000520.45390146
107Hippo signaling pathway_Homo sapiens_hsa043900.45045816
108Insulin resistance_Homo sapiens_hsa049310.44499237
109Purine metabolism_Homo sapiens_hsa002300.44418344
110Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43569334
111Chemical carcinogenesis_Homo sapiens_hsa052040.43290240
112Regulation of autophagy_Homo sapiens_hsa041400.42320135
113Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.40427389
114ABC transporters_Homo sapiens_hsa020100.39920646
115Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.39496416
116Shigellosis_Homo sapiens_hsa051310.39258912
117Collecting duct acid secretion_Homo sapiens_hsa049660.39031646
118Bile secretion_Homo sapiens_hsa049760.38836802
119Steroid hormone biosynthesis_Homo sapiens_hsa001400.37663832
120Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.36530570
121* N-Glycan biosynthesis_Homo sapiens_hsa005100.33881096
122Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.32750392
123Lysosome_Homo sapiens_hsa041420.30711226
124Thyroid cancer_Homo sapiens_hsa052160.30479080
125Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30070993
126Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.29925673
127Prion diseases_Homo sapiens_hsa050200.25681488
128Insulin secretion_Homo sapiens_hsa049110.24833195
129Pentose and glucuronate interconversions_Homo sapiens_hsa000400.22500620
130Arachidonic acid metabolism_Homo sapiens_hsa005900.18207942
131Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.17221553
132Retinol metabolism_Homo sapiens_hsa008300.17219278
133Longevity regulating pathway - mammal_Homo sapiens_hsa042110.16079603
134Renin secretion_Homo sapiens_hsa049240.15355756
135Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.15211181
136Synaptic vesicle cycle_Homo sapiens_hsa047210.14091274

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