DOLPP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: A similar gene has been characterized in mice and encodes dolichyl pyrophosphate (Dol-P-P) phosphatase. This protein dephosphorylates dolichyl pyrophosphate so that it may be re-utilized as a glycosyl carrier lipid by the oligosaccharyltransferase multisubunit complex in the ER. Alternative splicing results in multiple transcript variants and protein isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)4.80590503
2pyrimidine nucleobase catabolic process (GO:0006208)4.77638140
3cullin deneddylation (GO:0010388)4.68678152
4protein deneddylation (GO:0000338)4.49015831
5establishment of integrated proviral latency (GO:0075713)4.37366711
6proteasome assembly (GO:0043248)4.16628609
7formation of translation preinitiation complex (GO:0001731)4.11081563
8proline metabolic process (GO:0006560)4.06400018
9peptidyl-arginine omega-N-methylation (GO:0035247)4.04889520
10Golgi transport vesicle coating (GO:0048200)4.04659857
11COPI coating of Golgi vesicle (GO:0048205)4.04659857
12purine nucleobase biosynthetic process (GO:0009113)4.00252939
13protein insertion into membrane (GO:0051205)3.93769916
14histone arginine methylation (GO:0034969)3.90119708
15nucleobase biosynthetic process (GO:0046112)3.78893113
16folic acid metabolic process (GO:0046655)3.77971114
17deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.74730222
18pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.67609909
19nucleobase catabolic process (GO:0046113)3.67287569
20maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.63741045
21negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.63244654
22glycine metabolic process (GO:0006544)3.59740789
23negative regulation of DNA-templated transcription, elongation (GO:0032785)3.52107437
24protein retention in ER lumen (GO:0006621)3.51447940
25positive regulation of hormone biosynthetic process (GO:0046886)3.46486715
26establishment of viral latency (GO:0019043)3.43584651
27negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.42860219
28spliceosomal snRNP assembly (GO:0000387)3.41599985
29positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.41538045
30anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.41173359
31maturation of SSU-rRNA (GO:0030490)3.40860118
32positive regulation of megakaryocyte differentiation (GO:0045654)3.37815054
33termination of RNA polymerase III transcription (GO:0006386)3.36675629
34transcription elongation from RNA polymerase III promoter (GO:0006385)3.36675629
35mitotic sister chromatid segregation (GO:0000070)3.35355216
36regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.35260667
37regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.34188399
38negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.30825326
39negative regulation of ligase activity (GO:0051352)3.30825326
40DNA replication initiation (GO:0006270)3.29887808
41DNA unwinding involved in DNA replication (GO:0006268)3.24065607
42spliceosomal tri-snRNP complex assembly (GO:0000244)3.22354435
43nuclear envelope reassembly (GO:0031468)3.21842873
44mitotic nuclear envelope reassembly (GO:0007084)3.21842873
45regulation of mammary gland epithelial cell proliferation (GO:0033599)3.17699151
46DNA strand elongation involved in DNA replication (GO:0006271)3.17526618
47chaperone-mediated protein transport (GO:0072321)3.16584256
48mitotic chromosome condensation (GO:0007076)3.16129380
49nucleosome disassembly (GO:0006337)3.14697058
50protein-DNA complex disassembly (GO:0032986)3.14697058
51regulation of cellular amino acid metabolic process (GO:0006521)3.13779093
52protein complex localization (GO:0031503)3.08816647
53DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.08663741
54negative regulation of microtubule polymerization (GO:0031115)3.08421422
55tRNA aminoacylation for protein translation (GO:0006418)3.07629623
56L-serine metabolic process (GO:0006563)3.07564714
57intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.07465478
58signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.07465478
59signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.07046442
60signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.07046442
61signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.07046442
62ribosome assembly (GO:0042255)3.06781869
63pyrimidine nucleotide catabolic process (GO:0006244)3.05568751
64receptor recycling (GO:0001881)3.04872232
65DNA strand elongation (GO:0022616)3.04021262
66base-excision repair (GO:0006284)3.02371037
67RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.02287640
68tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.02287640
69DNA replication checkpoint (GO:0000076)3.01063722
70viral mRNA export from host cell nucleus (GO:0046784)3.00584471
71sister chromatid segregation (GO:0000819)2.98940293
72histone H4-K12 acetylation (GO:0043983)2.96772937
73de novo protein folding (GO:0006458)2.96569384
74signal transduction involved in DNA damage checkpoint (GO:0072422)2.96433294
75signal transduction involved in DNA integrity checkpoint (GO:0072401)2.96433294
76tRNA aminoacylation (GO:0043039)2.96076926
77amino acid activation (GO:0043038)2.96076926
78signal transduction involved in cell cycle checkpoint (GO:0072395)2.95051829
79mitotic metaphase plate congression (GO:0007080)2.94765752
80regulation of translational fidelity (GO:0006450)2.92122307
81protein localization to kinetochore (GO:0034501)2.92027217
82nuclear pore complex assembly (GO:0051292)2.91222180
83pyrimidine nucleobase metabolic process (GO:0006206)2.91060846
84de novo posttranslational protein folding (GO:0051084)2.89906136
85peptidyl-arginine N-methylation (GO:0035246)2.88131878
86peptidyl-arginine methylation (GO:0018216)2.88131878
87serine family amino acid biosynthetic process (GO:0009070)2.88082439
88pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.85500393
89positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.82573177
90positive regulation of hormone metabolic process (GO:0032352)2.80776314
91antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.80359560
92DNA ligation (GO:0006266)2.77413795
93protein maturation by protein folding (GO:0022417)2.77244982
94negative regulation of histone methylation (GO:0031061)2.77055599
95ribosome biogenesis (GO:0042254)2.74900951
96rRNA transcription (GO:0009303)2.74770123
97spliceosomal complex assembly (GO:0000245)2.74057277
98negative regulation of mRNA processing (GO:0050686)2.73944384
99telomere maintenance via semi-conservative replication (GO:0032201)2.72963810
100GDP-mannose metabolic process (GO:0019673)2.71770122
101metaphase plate congression (GO:0051310)2.71155922
102protein localization to chromosome, centromeric region (GO:0071459)2.70678150
103regulation of histone H3-K9 methylation (GO:0051570)2.70078612
104DNA topological change (GO:0006265)2.69272958
105positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.68295346
106iron-sulfur cluster assembly (GO:0016226)2.67476512
107metallo-sulfur cluster assembly (GO:0031163)2.67476512
108mitochondrial fusion (GO:0008053)2.67362688
109kinetochore assembly (GO:0051382)2.67236499
110positive regulation of ligase activity (GO:0051351)2.66643524
111folic acid transport (GO:0015884)2.66139131
112negative regulation of mRNA metabolic process (GO:1903312)2.66127286
113mitochondrial DNA metabolic process (GO:0032042)2.65066665
114regulation of translation in response to stress (GO:0043555)2.63992984
115negative regulation of translational initiation (GO:0045947)2.63857237
116ATP-dependent chromatin remodeling (GO:0043044)2.63748679
117folic acid-containing compound biosynthetic process (GO:0009396)2.63448575
118cholesterol biosynthetic process (GO:0006695)2.63263358
119mitochondrial RNA metabolic process (GO:0000959)2.61525687
1203-UTR-mediated mRNA stabilization (GO:0070935)2.59892785
121nucleoside diphosphate biosynthetic process (GO:0009133)2.59004272
122regulation of protein heterodimerization activity (GO:0043497)2.58994363
123cellular copper ion homeostasis (GO:0006878)2.58756720
124retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.58409897
125pseudouridine synthesis (GO:0001522)2.58406945
126transcription from mitochondrial promoter (GO:0006390)2.58389706
127glutamine family amino acid biosynthetic process (GO:0009084)2.58357503
128antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.58007894
129nuclear pore organization (GO:0006999)2.57313228
130DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.57002375
131nucleoside salvage (GO:0043174)2.56334454
132glucose 6-phosphate metabolic process (GO:0051156)2.55490410
133NADH metabolic process (GO:0006734)2.54939785
134mitotic nuclear envelope disassembly (GO:0007077)2.54649662
135heterochromatin organization (GO:0070828)2.54338095
136pyrimidine-containing compound catabolic process (GO:0072529)2.53777468
137nucleobase-containing small molecule interconversion (GO:0015949)2.52820157
138regulation of cellular amine metabolic process (GO:0033238)2.52572409
139negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.52326859
140histone H4-K5 acetylation (GO:0043981)2.52059798
141histone H4-K8 acetylation (GO:0043982)2.52059798
142nucleobase metabolic process (GO:0009112)2.51788934
143serine family amino acid catabolic process (GO:0009071)2.50236064
144nucleoside transmembrane transport (GO:1901642)2.49689500
145base-excision repair, AP site formation (GO:0006285)2.48895546
146serine family amino acid metabolic process (GO:0009069)2.48122288
147transcription-coupled nucleotide-excision repair (GO:0006283)2.47647453
148proline biosynthetic process (GO:0006561)2.47486824
149regulation of ubiquitin-protein transferase activity (GO:0051438)2.46095505
150CENP-A containing nucleosome assembly (GO:0034080)2.45765667
151telomere maintenance via telomere lengthening (GO:0010833)2.45396387
152activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.45228989
153positive regulation of cell cycle arrest (GO:0071158)2.44892225
154DNA damage response, detection of DNA damage (GO:0042769)2.44863226
1554-hydroxyproline metabolic process (GO:0019471)2.44510497
156translational initiation (GO:0006413)2.44301969
157telomere maintenance via recombination (GO:0000722)2.42247266
158chromatin remodeling at centromere (GO:0031055)2.41311644

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.08911315
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.88815533
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.44669698
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.08139806
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.04990032
6MYC_18358816_ChIP-ChIP_MESCs_Mouse2.90546066
7FOXM1_23109430_ChIP-Seq_U2OS_Human2.84603333
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.79875774
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.72430956
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.51593501
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.50580724
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.50411750
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.44976437
14* XRN2_22483619_ChIP-Seq_HELA_Human2.44876212
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.43317858
16* PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.41467785
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.37027729
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.33990068
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.31904957
20YY1_21170310_ChIP-Seq_MESCs_Mouse2.26669691
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.08027272
22THAP11_20581084_ChIP-Seq_MESCs_Mouse1.99768424
23E2F4_17652178_ChIP-ChIP_JURKAT_Human1.92485754
24E2F1_18555785_ChIP-Seq_MESCs_Mouse1.92337898
25POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.87810227
26POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.87030524
27* GABP_19822575_ChIP-Seq_HepG2_Human1.83234997
28* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.82636412
29DCP1A_22483619_ChIP-Seq_HELA_Human1.80265759
30SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.79420688
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.78364811
32* CIITA_25753668_ChIP-Seq_RAJI_Human1.77468492
33NANOG_18555785_ChIP-Seq_MESCs_Mouse1.76674612
34ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.75338642
35SRY_22984422_ChIP-ChIP_TESTIS_Rat1.74066257
36ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.73967568
37KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.71659227
38CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.68811219
39HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.67500332
40TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.65999101
41CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.63847859
42CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.62622596
43VDR_23849224_ChIP-Seq_CD4+_Human1.61228907
44E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.60473480
45FOXP3_21729870_ChIP-Seq_TREG_Human1.57912512
46TP63_17297297_ChIP-ChIP_HaCaT_Human1.57130615
47* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.56512076
48MYCN_18555785_ChIP-Seq_MESCs_Mouse1.53769805
49ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.48216176
50* TTF2_22483619_ChIP-Seq_HELA_Human1.42912169
51NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.42785780
52ESR1_15608294_ChIP-ChIP_MCF-7_Human1.42582631
53MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.41908744
54MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.41881425
55YY1_22570637_ChIP-Seq_MALME-3M_Human1.41018693
56PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.37944644
57KLF4_18555785_ChIP-Seq_MESCs_Mouse1.34661207
58VDR_21846776_ChIP-Seq_THP-1_Human1.32140950
59MYC_22102868_ChIP-Seq_BL_Human1.32049809
60SRF_21415370_ChIP-Seq_HL-1_Mouse1.31747246
61* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.31597081
62NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.30237751
63SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.26940641
64POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.26835756
65OCT4_18692474_ChIP-Seq_MEFs_Mouse1.26398274
66ZFX_18555785_ChIP-Seq_MESCs_Mouse1.26274436
67KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.24793662
68TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.23579614
69SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.22996911
70RBPJ_22232070_ChIP-Seq_NCS_Mouse1.22630194
71HOXB4_20404135_ChIP-ChIP_EML_Mouse1.21436930
72E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.18924350
73PPARA_22158963_ChIP-Seq_LIVER_Mouse1.18673562
74DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.18478941
75* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.18370262
76AR_21909140_ChIP-Seq_LNCAP_Human1.17535068
77KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.16689500
78NANOG_21062744_ChIP-ChIP_HESCs_Human1.16605665
79SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.15702908
80* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.14570040
81CLOCK_20551151_ChIP-Seq_293T_Human1.14366137
82* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.14330197
83ZNF263_19887448_ChIP-Seq_K562_Human1.13797507
84STAT3_1855785_ChIP-Seq_MESCs_Mouse1.11683355
85FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.11088847
86PHF8_20622854_ChIP-Seq_HELA_Human1.10533753
87ERG_20887958_ChIP-Seq_HPC-7_Mouse1.09724073
88NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.09711836
89PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09628312
90NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.08286772
91TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08142589
92TFEB_21752829_ChIP-Seq_HELA_Human1.07811849
93TET1_21451524_ChIP-Seq_MESCs_Mouse1.07648921
94KDM5A_27292631_Chip-Seq_BREAST_Human1.06925693
95P68_20966046_ChIP-Seq_HELA_Human1.06525815
96YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06339676
97* BCL6_27268052_Chip-Seq_Bcells_Human1.05882728
98CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.05758241
99FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.05323006
100BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04562666
101NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.04560795
102DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.03881463
103TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03040220
104E2F1_21310950_ChIP-Seq_MCF-7_Human1.02911558
105LXR_22292898_ChIP-Seq_THP-1_Human1.02117625
106RACK7_27058665_Chip-Seq_MCF-7_Human1.01903663
107* SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.01521505
108CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.01052725
109* BCOR_27268052_Chip-Seq_Bcells_Human1.00428569
110TBX5_21415370_ChIP-Seq_HL-1_Mouse1.00336263
111POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.99172893
112SOX2_18555785_ChIP-Seq_MESCs_Mouse0.99131693
113ELK1_22589737_ChIP-Seq_MCF10A_Human0.99112342
114* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.98739110
115* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98528368
116TCF3_18692474_ChIP-Seq_MEFs_Mouse0.97697183
117* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.97302780
118HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.97206311
119CTCF_18555785_ChIP-Seq_MESCs_Mouse0.96582444
120FOXP1_21924763_ChIP-Seq_HESCs_Human0.96545067
121ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.96378506
122ELF1_20517297_ChIP-Seq_JURKAT_Human0.96124541
123EGR1_19374776_ChIP-ChIP_THP-1_Human0.94807816
124CHD1_26751641_Chip-Seq_LNCaP_Human0.94102442
125CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.93552950
126SOX17_20123909_ChIP-Seq_XEN_Mouse0.93177980
127* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.91692814
128ZFP281_18757296_ChIP-ChIP_E14_Mouse0.91287204

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.96514295
2MP0003806_abnormal_nucleotide_metabolis3.81844820
3MP0009840_abnormal_foam_cell3.74950559
4MP0005360_urolithiasis3.21212609
5MP0008057_abnormal_DNA_replication3.10111135
6MP0004957_abnormal_blastocyst_morpholog2.95349001
7MP0003111_abnormal_nucleus_morphology2.63021460
8MP0009278_abnormal_bone_marrow2.62461382
9MP0003077_abnormal_cell_cycle2.53445046
10MP0010030_abnormal_orbit_morphology2.47676031
11MP0002653_abnormal_ependyma_morphology2.45803653
12MP0008932_abnormal_embryonic_tissue2.43952373
13MP0001346_abnormal_lacrimal_gland2.34613998
14MP0002796_impaired_skin_barrier2.19860060
15MP0005451_abnormal_body_composition2.18449400
16MP0008058_abnormal_DNA_repair2.14801943
17MP0004233_abnormal_muscle_weight2.12661076
18MP0001529_abnormal_vocalization2.06242037
19MP0002139_abnormal_hepatobiliary_system2.05567951
20MP0003718_maternal_effect2.03570599
21MP0010094_abnormal_chromosome_stability2.02916774
22MP0005365_abnormal_bile_salt1.97317924
23MP0005085_abnormal_gallbladder_physiolo1.95153513
24MP0003329_amyloid_beta_deposits1.87082829
25MP0001666_abnormal_nutrient_absorption1.85940137
26MP0004264_abnormal_extraembryonic_tissu1.85587367
27MP0005501_abnormal_skin_physiology1.82851386
28MP0001730_embryonic_growth_arrest1.80042988
29MP0003186_abnormal_redox_activity1.70732244
30MP0001764_abnormal_homeostasis1.68298815
31MP0001188_hyperpigmentation1.61862885
32MP0000566_synostosis1.61082797
33MP0009697_abnormal_copulation1.59632674
34MP0002638_abnormal_pupillary_reflex1.56214485
35MP0000350_abnormal_cell_proliferation1.53014237
36MP0005083_abnormal_biliary_tract1.49284490
37MP0003221_abnormal_cardiomyocyte_apopto1.48012979
38MP0010329_abnormal_lipoprotein_level1.44398019
39MP0002132_abnormal_respiratory_system1.40014764
40MP0002084_abnormal_developmental_patter1.39546153
41MP0004019_abnormal_vitamin_homeostasis1.34093993
42MP0008260_abnormal_autophagy1.32907644
43MP0003656_abnormal_erythrocyte_physiolo1.31644869
44MP0004133_heterotaxia1.30769381
45MP0006276_abnormal_autonomic_nervous1.30584903
46MP0010234_abnormal_vibrissa_follicle1.30401870
47MP0005266_abnormal_metabolism1.28954079
48MP0003119_abnormal_digestive_system1.27988404
49MP0003890_abnormal_embryonic-extraembry1.27862387
50MP0005623_abnormal_meninges_morphology1.24591079
51MP0000604_amyloidosis1.21874962
52MP0006035_abnormal_mitochondrial_morpho1.20536951
53MP0008007_abnormal_cellular_replicative1.18644410
54MP0005377_hearing/vestibular/ear_phenot1.17393648
55MP0003878_abnormal_ear_physiology1.17393648
56MP0010352_gastrointestinal_tract_polyps1.16643194
57MP0004197_abnormal_fetal_growth/weight/1.16020008
58MP0003191_abnormal_cellular_cholesterol1.15568776
59MP0005397_hematopoietic_system_phenotyp1.12551184
60MP0001545_abnormal_hematopoietic_system1.12551184
61MP0001727_abnormal_embryo_implantation1.11937710
62MP0002086_abnormal_extraembryonic_tissu1.10786777
63MP0001661_extended_life_span1.09293589
64MP0008789_abnormal_olfactory_epithelium1.08996803
65MP0005332_abnormal_amino_acid1.08842284
66MP0000609_abnormal_liver_physiology1.05769919
67MP0002080_prenatal_lethality1.03569113
68MP0000490_abnormal_crypts_of1.03376429
69MP0000647_abnormal_sebaceous_gland1.03190292
70MP0002751_abnormal_autonomic_nervous1.02732218
71MP0002277_abnormal_respiratory_mucosa1.01759213
72MP0000538_abnormal_urinary_bladder1.01289152
73MP0003938_abnormal_ear_development1.00787272
74MP0003436_decreased_susceptibility_to1.00746752
75MP0002254_reproductive_system_inflammat0.99979552
76MP0001697_abnormal_embryo_size0.99289170
77MP0005394_taste/olfaction_phenotype0.99229421
78MP0005499_abnormal_olfactory_system0.99229421
79MP0002877_abnormal_melanocyte_morpholog0.98684595
80MP0004147_increased_porphyrin_level0.98533310
81MP0004185_abnormal_adipocyte_glucose0.98290200
82MP0002697_abnormal_eye_size0.97701998
83MP0003786_premature_aging0.96275417
84MP0005376_homeostasis/metabolism_phenot0.96181736
85MP0000313_abnormal_cell_death0.93783224
86MP0001672_abnormal_embryogenesis/_devel0.93417783
87MP0005380_embryogenesis_phenotype0.93417783
88MP0004272_abnormal_basement_membrane0.93329081
89MP0005319_abnormal_enzyme/_coenzyme0.92720948
90MP0003941_abnormal_skin_development0.92677623
91MP0004782_abnormal_surfactant_physiolog0.92343554
92MP0001216_abnormal_epidermal_layer0.92293072
93MP0003937_abnormal_limbs/digits/tail_de0.91624033
94MP0001984_abnormal_olfaction0.91409471
95MP0000049_abnormal_middle_ear0.91247943
96MP0005187_abnormal_penis_morphology0.90938198
97MP0000358_abnormal_cell_content/0.89911026
98MP0002822_catalepsy0.89850609
99MP0006036_abnormal_mitochondrial_physio0.88504012
100MP0004858_abnormal_nervous_system0.87651968
101MP0001849_ear_inflammation0.86925800
102MP0003567_abnormal_fetal_cardiomyocyte0.86220415
103MP0008961_abnormal_basal_metabolism0.86207516
104MP0001881_abnormal_mammary_gland0.85894871
105MP0002098_abnormal_vibrissa_morphology0.85086490
106MP0005076_abnormal_cell_differentiation0.84975786
107MP0001243_abnormal_dermal_layer0.84742143
108MP0003861_abnormal_nervous_system0.84488495
109MP0003123_paternal_imprinting0.83389352
110MP0002085_abnormal_embryonic_tissue0.83294447
111MP0001919_abnormal_reproductive_system0.81755752
112MP0000467_abnormal_esophagus_morphology0.81685009
113MP0009703_decreased_birth_body0.81024200
114MP0000537_abnormal_urethra_morphology0.80931815
115MP0002249_abnormal_larynx_morphology0.80428343
116MP0003283_abnormal_digestive_organ0.79484188
117MP0005636_abnormal_mineral_homeostasis0.79381944
118MP0002111_abnormal_tail_morphology0.79232196
119MP0002092_abnormal_eye_morphology0.79051002
120MP0002233_abnormal_nose_morphology0.79029039
121MP0003705_abnormal_hypodermis_morpholog0.76057508
122MP0009672_abnormal_birth_weight0.75960299
123MP0005384_cellular_phenotype0.75174398
124MP0000462_abnormal_digestive_system0.75168907
125MP0000678_abnormal_parathyroid_gland0.73876663
126MP0004381_abnormal_hair_follicle0.73874145
127MP0002970_abnormal_white_adipose0.73763914
128MP0002735_abnormal_chemical_nociception0.73760404
129MP0000377_abnormal_hair_follicle0.72583490
130MP0002089_abnormal_postnatal_growth/wei0.71687668
131MP0000579_abnormal_nail_morphology0.71532407
132MP0005448_abnormal_energy_balance0.71174474
133MP0002102_abnormal_ear_morphology0.70837281
134MP0002088_abnormal_embryonic_growth/wei0.70231861
135MP0009931_abnormal_skin_appearance0.69571660
136MP0005058_abnormal_lysosome_morphology0.69178318
137MP0002118_abnormal_lipid_homeostasis0.68935986
138MP0003984_embryonic_growth_retardation0.68776545
139MP0000367_abnormal_coat/_hair0.68558787
140MP0001293_anophthalmia0.67625792
141MP0004947_skin_inflammation0.67133255
142MP0003315_abnormal_perineum_morphology0.66745617

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the anterior horn cell (HP:0006802)4.36847294
2Degeneration of anterior horn cells (HP:0002398)4.36847294
3Hypobetalipoproteinemia (HP:0003563)4.26566154
4Cerebral hypomyelination (HP:0006808)3.82070977
5Back pain (HP:0003418)3.61314574
6Ragged-red muscle fibers (HP:0003200)3.57875829
7Oral leukoplakia (HP:0002745)3.53452735
8Abnormality of glycolysis (HP:0004366)3.43843733
9Increased serum pyruvate (HP:0003542)3.43843733
10Atrophy/Degeneration involving motor neurons (HP:0007373)3.41379469
11Opisthotonus (HP:0002179)3.15954088
12Microretrognathia (HP:0000308)3.13730206
13Ileus (HP:0002595)3.13149298
14Hyperglycinuria (HP:0003108)2.85541063
15Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.85247403
16Multiple enchondromatosis (HP:0005701)2.76618448
17Abnormal neuron morphology (HP:0012757)2.70441664
18Abnormality of the motor neurons (HP:0002450)2.70441664
19Abnormality of serine family amino acid metabolism (HP:0010894)2.69596516
20Abnormality of glycine metabolism (HP:0010895)2.69596516
21Rough bone trabeculation (HP:0100670)2.69056482
22Shoulder girdle muscle weakness (HP:0003547)2.68009662
23Patellar aplasia (HP:0006443)2.61264466
24Hyperglycinemia (HP:0002154)2.53873749
25Insomnia (HP:0100785)2.52788353
26Overriding aorta (HP:0002623)2.50363141
27Aplasia/Hypoplasia of the patella (HP:0006498)2.48556732
28Breast hypoplasia (HP:0003187)2.47515179
29Bilateral microphthalmos (HP:0007633)2.46913534
30Secondary amenorrhea (HP:0000869)2.44302365
31Personality changes (HP:0000751)2.42410146
32Trismus (HP:0000211)2.41908384
33Wide cranial sutures (HP:0010537)2.40873636
34Hypolipoproteinemia (HP:0010981)2.40549739
35Hyperacusis (HP:0010780)2.38113943
36Cholelithiasis (HP:0001081)2.37130683
37Upper limb muscle weakness (HP:0003484)2.35054225
38Spastic diplegia (HP:0001264)2.34422659
39Agnosia (HP:0010524)2.33257796
40Delayed CNS myelination (HP:0002188)2.28603690
41Abnormal protein glycosylation (HP:0012346)2.28328522
42Abnormal glycosylation (HP:0012345)2.28328522
43Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.28328522
44Abnormal protein N-linked glycosylation (HP:0012347)2.28328522
45Sparse eyelashes (HP:0000653)2.26625077
46Abnormality of monocarboxylic acid metabolism (HP:0010996)2.25881599
47Abnormality of the aortic arch (HP:0012303)2.25752646
48Postnatal microcephaly (HP:0005484)2.21729712
49Pseudobulbar signs (HP:0002200)2.21049049
50Increased serum lactate (HP:0002151)2.20405134
51Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.19669987
52Abnormal gallbladder physiology (HP:0012438)2.18478103
53Cholecystitis (HP:0001082)2.18478103
54Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.17260201
55Decreased activity of mitochondrial respiratory chain (HP:0008972)2.17260201
56Hyperammonemia (HP:0001987)2.16908093
57Abnormality of alanine metabolism (HP:0010916)2.15849863
58Hyperalaninemia (HP:0003348)2.15849863
59Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.15849863
60Death in infancy (HP:0001522)2.15545209
61Broad distal phalanx of finger (HP:0009836)2.14765432
62Congenital ichthyosiform erythroderma (HP:0007431)2.14552882
63Cellular immunodeficiency (HP:0005374)2.13312868
64Abnormality of pyrimidine metabolism (HP:0004353)2.11880317
65Xanthomatosis (HP:0000991)2.09997465
66Abnormality of the umbilical cord (HP:0010881)2.09834667
67Reduced antithrombin III activity (HP:0001976)2.08118875
68Selective tooth agenesis (HP:0001592)2.07518564
69Hyperbilirubinemia (HP:0002904)2.07423028
70Proximal placement of thumb (HP:0009623)2.07109573
71Abnormal gallbladder morphology (HP:0012437)2.06135298
72Abnormality of the labia minora (HP:0012880)2.05912672
73Vaginal fistula (HP:0004320)2.05298062
74Ependymoma (HP:0002888)2.05177676
75Abnormality of serum amino acid levels (HP:0003112)2.03571534
76Increased nuchal translucency (HP:0010880)2.02877794
77CNS demyelination (HP:0007305)2.02345913
78Pelvic girdle muscle weakness (HP:0003749)2.01934821
79Birth length less than 3rd percentile (HP:0003561)1.99912667
80Reticulocytosis (HP:0001923)1.98853716
81Amyotrophic lateral sclerosis (HP:0007354)1.98697659
82Microvesicular hepatic steatosis (HP:0001414)1.98590066
83Delusions (HP:0000746)1.97025668
84Abnormality of the gallbladder (HP:0005264)1.94558122
85Poor suck (HP:0002033)1.93977860
86Chromsome breakage (HP:0040012)1.93746260
87Abnormality of reticulocytes (HP:0004312)1.93387448
88Deviation of the thumb (HP:0009603)1.93140661
89Type I transferrin isoform profile (HP:0003642)1.92260607
90Abnormality of the lower motor neuron (HP:0002366)1.92198816
91Facial cleft (HP:0002006)1.92004532
92Hand muscle atrophy (HP:0009130)1.91365987
93Abnormality of the distal phalanges of the toes (HP:0010182)1.91123562
94Achilles tendon contracture (HP:0001771)1.91110859
95Chromosomal breakage induced by crosslinking agents (HP:0003221)1.89375902
96Carpal bone hypoplasia (HP:0001498)1.88126192
97Horseshoe kidney (HP:0000085)1.87824937
98Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.87122778
99Tongue fasciculations (HP:0001308)1.87079400
100Hypokinesia (HP:0002375)1.86915982
101Brushfield spots (HP:0001088)1.86562337
102Dysphonia (HP:0001618)1.86465876
103Abnormal trabecular bone morphology (HP:0100671)1.86250438
104Aplasia/Hypoplasia involving the musculature (HP:0001460)1.84249907
105Emotional lability (HP:0000712)1.83866193
106Delayed myelination (HP:0012448)1.83738130
107Reticulocytopenia (HP:0001896)1.83669640
108Gastrointestinal dysmotility (HP:0002579)1.83592966
109Abnormality of the Achilles tendon (HP:0005109)1.83507968
110Type I diabetes mellitus (HP:0100651)1.83489333
111Premature ovarian failure (HP:0008209)1.82378712
112Long palpebral fissure (HP:0000637)1.81720762
113Progressive muscle weakness (HP:0003323)1.81268924
114Aplasia/Hypoplasia of the sacrum (HP:0008517)1.80993812
115Abnormality of sulfur amino acid metabolism (HP:0004339)1.80236906
116High anterior hairline (HP:0009890)1.80022997
117Progressive external ophthalmoplegia (HP:0000590)1.79721867
118Gout (HP:0001997)1.79179173
119Irritability (HP:0000737)1.79097038
120Abnormality of the hip-girdle musculature (HP:0001445)1.78615105
121Abnormality of the musculature of the pelvis (HP:0001469)1.78615105
122Dysautonomia (HP:0002459)1.77476702
123Cortical dysplasia (HP:0002539)1.77339268
124Insidious onset (HP:0003587)1.77257616
125Termporal pattern (HP:0011008)1.77257616
126Abnormality of liposaccharide metabolism (HP:0010968)1.77223327
127Abnormality of glycosphingolipid metabolism (HP:0004343)1.77223327
128Abnormality of glycolipid metabolism (HP:0010969)1.77223327
129Hepatic necrosis (HP:0002605)1.76548982
130Septate vagina (HP:0001153)1.75898561
131Abnormal lung lobation (HP:0002101)1.75887093
132Cerebellar hypoplasia (HP:0001321)1.75391312
133Abnormalities of placenta or umbilical cord (HP:0001194)1.75057509
134Limb-girdle muscle atrophy (HP:0003797)1.74792300
135Overlapping toe (HP:0001845)1.73428280
136Hypoplasia of the capital femoral epiphysis (HP:0003090)1.73427875
137Seborrheic dermatitis (HP:0001051)1.72831312
138Fasciculations (HP:0002380)1.72610465
139Lethargy (HP:0001254)1.71873336
140Abnormal number of incisors (HP:0011064)1.71584221
141Abnormal umbilical cord blood vessels (HP:0011403)1.71269933
142Single umbilical artery (HP:0001195)1.71269933
143Abnormality of the fetal cardiovascular system (HP:0010948)1.71269933
144Centrally nucleated skeletal muscle fibers (HP:0003687)1.70327659
145Pili torti (HP:0003777)1.70311758
146Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.69129926
147Hepatocellular necrosis (HP:0001404)1.68679392
148Upper limb amyotrophy (HP:0009129)1.68520389
149Distal upper limb amyotrophy (HP:0007149)1.68520389
150Distal lower limb amyotrophy (HP:0008944)1.66523918
151Glossoptosis (HP:0000162)1.66272045
152Peripheral hypomyelination (HP:0007182)1.65124699
153Anophthalmia (HP:0000528)1.64328200
154CNS hypomyelination (HP:0003429)1.63640079
155Generalized hypotonia (HP:0001290)1.62529221
156Angiofibromas (HP:0010615)1.62288509
157Adenoma sebaceum (HP:0009720)1.62288509
158Neoplasm of the adrenal gland (HP:0100631)1.60496828
159Deep venous thrombosis (HP:0002625)1.60450863
160Hypoplastic pelvis (HP:0008839)1.60420505
161Concave nail (HP:0001598)1.59602050
162Aplasia/Hypoplasia of the sternum (HP:0006714)1.59212466
163Choanal stenosis (HP:0000452)1.57097266
164Abnormality of methionine metabolism (HP:0010901)1.57062729
165Hammertoe (HP:0001765)1.57050289
166Down-sloping shoulders (HP:0200021)1.56899503
167Megaloblastic anemia (HP:0001889)1.56757914
1683-Methylglutaconic aciduria (HP:0003535)1.55993861
169Impulsivity (HP:0100710)1.55619000
170Abnormality of alkaline phosphatase activity (HP:0004379)1.53046511
171Intrahepatic cholestasis (HP:0001406)1.51763471

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.37118607
2VRK24.00419566
3BLK3.96021119
4SIK33.68879761
5ERN13.32382210
6TESK23.13332025
7TESK12.62117051
8NEK12.52283388
9SMG12.41608551
10PBK2.36503942
11BCR2.26515377
12STK162.19282270
13DYRK22.11254121
14MAPKAPK32.09005908
15PRPF4B2.05757915
16TLK12.04783109
17WEE12.04435001
18UHMK12.02594860
19CDK121.92792450
20LIMK11.86997302
21NME21.86821465
22TAOK21.80620186
23AURKA1.73496609
24EPHA21.67314577
25TRIM281.64048855
26BCKDK1.53980952
27PASK1.49504656
28MAP3K91.46130622
29PLK11.45062790
30PIM21.44070980
31PAK41.41749014
32CDK71.36330077
33MARK11.34870458
34CDC71.32658927
35PLK41.32184687
36TTK1.28079068
37EEF2K1.27458886
38MAP2K71.22223369
39ACVR1B1.21992363
40KSR11.21763985
41CDK81.20867044
42STK101.18120772
43SRPK11.17170633
44NEK21.16782335
45DYRK31.12748082
46MINK11.10611133
47NTRK11.07364356
48PKN21.06385850
49CDK191.06195366
50TSSK61.05692036
51CCNB11.04488622
52NME11.03183019
53DAPK11.01906325
54ICK0.98479241
55SCYL20.98474764
56FGFR40.97269601
57EIF2AK10.92901194
58MUSK0.91593510
59CDK180.90996483
60AURKB0.89370030
61PAK10.89210178
62MAP3K80.88989517
63IRAK30.88119891
64MAP3K110.87605279
65BRAF0.87224310
66PRKCI0.85976920
67PLK30.85222562
68GRK60.81761657
69BRSK10.80917689
70CSNK1A1L0.79693857
71ERBB30.78731274
72VRK10.76557981
73MST40.76086864
74MAP2K20.75189981
75ATR0.74577144
76RPS6KB20.74443977
77MAP3K100.73847523
78CLK10.71286884
79RPS6KA40.71019065
80IRAK20.69501804
81CDK150.68847657
82CDK140.68080428
83CDK90.66210561
84DYRK1B0.65218822
85RAF10.65114954
86CSNK1G10.64557090
87LMTK20.63987361
88FER0.63596627
89CDK11A0.63422865
90ARAF0.62996986
91CAMK1G0.62834022
92EIF2AK30.62659792
93MST1R0.61897336
94ZAK0.61723855
95IRAK40.61276412
96CSNK1G20.61018634
97CDK40.56837712
98PRKG20.56439308
99ZAP700.56281586
100ATM0.55180171
101ERBB40.54117701
102KDR0.53737349
103MTOR0.52578733
104BMX0.51449002
105CSNK1E0.50412839
106KSR20.50200710
107STK40.49217116
108ILK0.48400591
109MAPKAPK20.46623925
110CHEK20.45620166
111CDK10.45465463
112ALK0.45413752
113MET0.44164235
114BRSK20.44148687
115MAP4K20.43301437
116IRAK10.42175016
117MATK0.41445879
118ABL20.41137403
119CDK60.39935881
120DAPK30.39453068
121MAPK40.39279846
122CSNK2A20.37407666
123MAP2K60.36097361
124TYRO30.35807730
125CSNK2A10.34349286
126CDK20.33626754
127MKNK10.32349550
128FGFR10.32230806
129AKT20.30376789
130CSNK1G30.30083300
131RPS6KA20.29952642
132TRIB30.29143618
133PRKCZ0.28326146
134MAPK90.27605345
135MAPK110.27290804
136PRKCD0.27265811
137SIK10.26352276
138CHEK10.26135480

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.61827523
2DNA replication_Homo sapiens_hsa030303.01766860
3RNA polymerase_Homo sapiens_hsa030202.75691006
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.60107209
5Spliceosome_Homo sapiens_hsa030402.39430409
6Base excision repair_Homo sapiens_hsa034102.30211577
7Sulfur relay system_Homo sapiens_hsa041222.26083770
8Pyrimidine metabolism_Homo sapiens_hsa002402.23523389
9Ribosome_Homo sapiens_hsa030102.21262348
10Mismatch repair_Homo sapiens_hsa034302.21051364
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.13380617
12Cyanoamino acid metabolism_Homo sapiens_hsa004602.08450450
13RNA transport_Homo sapiens_hsa030132.06914751
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.05375271
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.01997947
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.94350741
17Steroid biosynthesis_Homo sapiens_hsa001001.86676429
18Drug metabolism - other enzymes_Homo sapiens_hsa009831.79056782
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.78932865
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.78843595
21Folate biosynthesis_Homo sapiens_hsa007901.74952811
22Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.74159986
23One carbon pool by folate_Homo sapiens_hsa006701.66424241
24Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.53335921
25Biosynthesis of amino acids_Homo sapiens_hsa012301.52049770
26Fat digestion and absorption_Homo sapiens_hsa049751.48451518
27Pentose phosphate pathway_Homo sapiens_hsa000301.47367875
28Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.46190806
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.44646453
30Carbon metabolism_Homo sapiens_hsa012001.44204372
31Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.44139593
32Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.33500439
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.30162884
34Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.27726973
35Nucleotide excision repair_Homo sapiens_hsa034201.27056614
36Fructose and mannose metabolism_Homo sapiens_hsa000511.25351941
37Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.23063017
38Cell cycle_Homo sapiens_hsa041101.19464968
39Pentose and glucuronate interconversions_Homo sapiens_hsa000401.18489165
40Galactose metabolism_Homo sapiens_hsa000521.18471526
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.17745752
42Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.12905176
43Phenylalanine metabolism_Homo sapiens_hsa003601.12313873
44Fatty acid degradation_Homo sapiens_hsa000711.10465728
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.09934097
46Glutathione metabolism_Homo sapiens_hsa004801.05113700
47Peroxisome_Homo sapiens_hsa041461.04813115
48Sulfur metabolism_Homo sapiens_hsa009201.02987374
49Purine metabolism_Homo sapiens_hsa002301.01619214
50Tryptophan metabolism_Homo sapiens_hsa003801.01320042
51Fatty acid metabolism_Homo sapiens_hsa012121.00042490
52Butanoate metabolism_Homo sapiens_hsa006500.99168594
53Vitamin digestion and absorption_Homo sapiens_hsa049770.98888497
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.98884819
55Vitamin B6 metabolism_Homo sapiens_hsa007500.95309813
56Selenocompound metabolism_Homo sapiens_hsa004500.94521832
57Fatty acid elongation_Homo sapiens_hsa000620.94052731
58Primary bile acid biosynthesis_Homo sapiens_hsa001200.90794690
59Histidine metabolism_Homo sapiens_hsa003400.87562182
60Vibrio cholerae infection_Homo sapiens_hsa051100.87141454
61Starch and sucrose metabolism_Homo sapiens_hsa005000.85961453
62Thyroid cancer_Homo sapiens_hsa052160.85537491
63Arginine and proline metabolism_Homo sapiens_hsa003300.85333623
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.83755041
65Pyruvate metabolism_Homo sapiens_hsa006200.80992137
66Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.80836294
67beta-Alanine metabolism_Homo sapiens_hsa004100.80566494
68Oxidative phosphorylation_Homo sapiens_hsa001900.78932781
69Parkinsons disease_Homo sapiens_hsa050120.78478670
70Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.77784053
71Epstein-Barr virus infection_Homo sapiens_hsa051690.76560438
72Metabolic pathways_Homo sapiens_hsa011000.73368337
73Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70479747
74Retinol metabolism_Homo sapiens_hsa008300.65474578
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64728508
76Arginine biosynthesis_Homo sapiens_hsa002200.63264358
77p53 signaling pathway_Homo sapiens_hsa041150.61406696
78Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.60439651
79Tyrosine metabolism_Homo sapiens_hsa003500.59257967
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.58911451
81Homologous recombination_Homo sapiens_hsa034400.57006079
82Huntingtons disease_Homo sapiens_hsa050160.56508720
83mRNA surveillance pathway_Homo sapiens_hsa030150.55764498
84Renin-angiotensin system_Homo sapiens_hsa046140.51675884
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50284434
86Bladder cancer_Homo sapiens_hsa052190.49877835
87Caffeine metabolism_Homo sapiens_hsa002320.48610932
88Protein export_Homo sapiens_hsa030600.48574979
89Adherens junction_Homo sapiens_hsa045200.48123647
90Basal transcription factors_Homo sapiens_hsa030220.47925635
91Chemical carcinogenesis_Homo sapiens_hsa052040.47521313
92Lysine degradation_Homo sapiens_hsa003100.47115701
93PPAR signaling pathway_Homo sapiens_hsa033200.46250065
94Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.45967005
95Shigellosis_Homo sapiens_hsa051310.45674080
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.45375248
97Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.41865730
98Other glycan degradation_Homo sapiens_hsa005110.39183068
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.39130533
100Oocyte meiosis_Homo sapiens_hsa041140.37905712
101Basal cell carcinoma_Homo sapiens_hsa052170.37900579
102RNA degradation_Homo sapiens_hsa030180.37147339
103Glycerolipid metabolism_Homo sapiens_hsa005610.36954373
104* N-Glycan biosynthesis_Homo sapiens_hsa005100.36851018
105AMPK signaling pathway_Homo sapiens_hsa041520.36510489
106Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.35760006
107Steroid hormone biosynthesis_Homo sapiens_hsa001400.35657172
108Non-homologous end-joining_Homo sapiens_hsa034500.34230115
109Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.33857169
110Staphylococcus aureus infection_Homo sapiens_hsa051500.33387046
111Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.33327435
112Regulation of autophagy_Homo sapiens_hsa041400.31789425
113Apoptosis_Homo sapiens_hsa042100.31611092
114Propanoate metabolism_Homo sapiens_hsa006400.31592722
115Viral carcinogenesis_Homo sapiens_hsa052030.31371203
116Fanconi anemia pathway_Homo sapiens_hsa034600.30060267
117Hippo signaling pathway_Homo sapiens_hsa043900.29765359
118Alcoholism_Homo sapiens_hsa050340.29241383
119Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.28709160
120Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.27148320

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