DONSON

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene lies downstream of the SON gene and spans 10 kb on chromosome 21. The function of this gene is unknown. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic sister chromatid cohesion (GO:0007064)4.58153390
2DNA unwinding involved in DNA replication (GO:0006268)4.57659873
3DNA replication initiation (GO:0006270)4.47189950
4nuclear pore organization (GO:0006999)4.44094050
5nuclear pore complex assembly (GO:0051292)4.35755966
6protein localization to chromosome, centromeric region (GO:0071459)4.26814858
7DNA strand elongation involved in DNA replication (GO:0006271)4.23514663
8protein localization to kinetochore (GO:0034501)4.18308704
9DNA strand elongation (GO:0022616)4.00023913
10translesion synthesis (GO:0019985)3.99434344
11regulation of centriole replication (GO:0046599)3.95676469
12heterochromatin organization (GO:0070828)3.94613349
13regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.94499840
14DNA replication-dependent nucleosome organization (GO:0034723)3.93788903
15DNA replication-dependent nucleosome assembly (GO:0006335)3.93788903
16DNA topological change (GO:0006265)3.92664414
17DNA replication checkpoint (GO:0000076)3.91487875
18telomere maintenance via semi-conservative replication (GO:0032201)3.83865946
19regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.76985404
20mitotic chromosome condensation (GO:0007076)3.76336042
21telomere maintenance via recombination (GO:0000722)3.68726355
22mitotic nuclear envelope disassembly (GO:0007077)3.65027877
23mitotic sister chromatid segregation (GO:0000070)3.65020194
24synapsis (GO:0007129)3.62716444
25cilium or flagellum-dependent cell motility (GO:0001539)3.56126295
26mitotic recombination (GO:0006312)3.54466501
27mitotic metaphase plate congression (GO:0007080)3.53225808
28protein localization to chromosome (GO:0034502)3.47216403
29sister chromatid segregation (GO:0000819)3.47215739
30membrane disassembly (GO:0030397)3.43402096
31nuclear envelope disassembly (GO:0051081)3.43402096
32monoubiquitinated protein deubiquitination (GO:0035520)3.38403748
33DNA replication-independent nucleosome assembly (GO:0006336)3.36169456
34DNA replication-independent nucleosome organization (GO:0034724)3.36169456
35postreplication repair (GO:0006301)3.35784619
36chromatin remodeling at centromere (GO:0031055)3.35431093
37kinetochore assembly (GO:0051382)3.33048443
38metaphase plate congression (GO:0051310)3.31892774
39CENP-A containing nucleosome assembly (GO:0034080)3.30998820
40regulation of centrosome cycle (GO:0046605)3.30028194
41histone exchange (GO:0043486)3.27426834
42regulation of histone H3-K9 methylation (GO:0051570)3.23858043
43spindle checkpoint (GO:0031577)3.23711193
44regulation of mitotic spindle organization (GO:0060236)3.20335922
45regulation of translational fidelity (GO:0006450)3.19849401
46DNA strand renaturation (GO:0000733)3.19531599
47establishment of chromosome localization (GO:0051303)3.19491363
48resolution of meiotic recombination intermediates (GO:0000712)3.19419168
49positive regulation of mitotic sister chromatid separation (GO:1901970)3.19259827
50positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.19259827
51positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.19259827
52replication fork processing (GO:0031297)3.18232958
53nucleotide-excision repair, DNA gap filling (GO:0006297)3.18166794
54regulation of DNA endoreduplication (GO:0032875)3.16357583
55regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.15576638
56negative regulation of chromosome segregation (GO:0051985)3.15213202
57meiotic chromosome segregation (GO:0045132)3.15203925
58pore complex assembly (GO:0046931)3.14518199
59intra-S DNA damage checkpoint (GO:0031573)3.13706043
60telomere maintenance via telomere lengthening (GO:0010833)3.13176638
61negative regulation of histone methylation (GO:0031061)3.12506774
62mitotic spindle checkpoint (GO:0071174)3.11698639
63positive regulation of chromosome segregation (GO:0051984)3.10923968
64chromatin assembly or disassembly (GO:0006333)3.10431577
65DNA geometric change (GO:0032392)3.09790505
66chromosome condensation (GO:0030261)3.09779816
67attachment of spindle microtubules to kinetochore (GO:0008608)3.09725625
68formation of translation preinitiation complex (GO:0001731)3.09510749
69DNA ligation (GO:0006266)3.09448677
70DNA duplex unwinding (GO:0032508)3.09294912
71negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.08666348
72purine nucleobase biosynthetic process (GO:0009113)3.08263295
73establishment of integrated proviral latency (GO:0075713)3.08212975
74microtubule depolymerization (GO:0007019)3.07138180
75non-recombinational repair (GO:0000726)3.07098944
76double-strand break repair via nonhomologous end joining (GO:0006303)3.07098944
77sperm-egg recognition (GO:0035036)3.06045489
78mismatch repair (GO:0006298)3.04262315
79DNA packaging (GO:0006323)3.03735595
80negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.02623204
81negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.02623204
82negative regulation of mitotic sister chromatid segregation (GO:0033048)3.02623204
83negative regulation of mitotic sister chromatid separation (GO:2000816)3.02623204
84negative regulation of sister chromatid segregation (GO:0033046)3.02623204
85positive regulation of DNA-dependent DNA replication (GO:2000105)3.01576702
86kinetochore organization (GO:0051383)3.01027696
87mitotic spindle assembly checkpoint (GO:0007094)2.98658167
88binding of sperm to zona pellucida (GO:0007339)2.98590056
89regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.98402965
90regulation of mitotic metaphase/anaphase transition (GO:0030071)2.98402965
91negative regulation of mRNA processing (GO:0050686)2.98010895
92regulation of sister chromatid segregation (GO:0033045)2.97440237
93regulation of mitotic sister chromatid separation (GO:0010965)2.97440237
94regulation of mitotic sister chromatid segregation (GO:0033047)2.97440237
95fusion of sperm to egg plasma membrane (GO:0007342)2.96723386
96DNA conformation change (GO:0071103)2.96452215
97folic acid-containing compound biosynthetic process (GO:0009396)2.94581464
98spindle assembly checkpoint (GO:0071173)2.94491382
99cell-cell recognition (GO:0009988)2.94442673
100mitotic cell cycle (GO:0000278)2.94398265
101sister chromatid cohesion (GO:0007062)2.93853781
102DNA synthesis involved in DNA repair (GO:0000731)2.91475095
103protein K6-linked ubiquitination (GO:0085020)2.91126012
104regulation of DNA-dependent DNA replication (GO:0090329)2.91100291
105pre-miRNA processing (GO:0031054)2.89322970
106regulation of sister chromatid cohesion (GO:0007063)2.87145941
107somatic diversification of immune receptors via somatic mutation (GO:0002566)2.86352993
108somatic hypermutation of immunoglobulin genes (GO:0016446)2.86352993
109regulation of chromosome segregation (GO:0051983)2.83457811
110piRNA metabolic process (GO:0034587)2.81063399
111regulation of double-strand break repair via homologous recombination (GO:0010569)2.80410391
112regulation of centrosome duplication (GO:0010824)2.80406153
113maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.80008555
114ATP-dependent chromatin remodeling (GO:0043044)2.76593520
115regulation of histone H3-K27 methylation (GO:0061085)2.76032824
116meiotic nuclear division (GO:0007126)2.72862862
117gene silencing by RNA (GO:0031047)2.71597425
118dosage compensation (GO:0007549)2.69695590
119chromosome segregation (GO:0007059)2.66108937
120regulation of spindle organization (GO:0090224)2.65882695
121male meiosis (GO:0007140)2.65727280
122chromosome organization (GO:0051276)2.65472991
123motile cilium assembly (GO:0044458)2.64562540
124regulation of helicase activity (GO:0051095)2.63243101
125telomere maintenance (GO:0000723)2.61847492
126histone mRNA catabolic process (GO:0071044)2.61137978
127regulation of chromatin binding (GO:0035561)2.59926852
128telomere organization (GO:0032200)2.59370742
129chromosome organization involved in meiosis (GO:0070192)2.58220678
130male meiosis I (GO:0007141)2.55478392
131histone phosphorylation (GO:0016572)2.55441772
132chromatin assembly (GO:0031497)2.55368659
133histone H2A acetylation (GO:0043968)2.55077001
134IMP biosynthetic process (GO:0006188)2.54173799
135nucleobase biosynthetic process (GO:0046112)2.54014432

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.92601929
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.37022099
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.65564230
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.28733329
5MYC_18555785_ChIP-Seq_MESCs_Mouse2.95865444
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.81276558
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.55382969
8* E2F1_21310950_ChIP-Seq_MCF-7_Human2.41239267
9MYC_22102868_ChIP-Seq_BL_Human2.36812443
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.13658262
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.10024715
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.07887457
13AR_21909140_ChIP-Seq_LNCAP_Human2.04841675
14E2F7_22180533_ChIP-Seq_HELA_Human11.6455691
15* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.97141680
16MYC_18358816_ChIP-ChIP_MESCs_Mouse1.91376485
17VDR_23849224_ChIP-Seq_CD4+_Human1.90551770
18ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.90360492
19RBPJ_22232070_ChIP-Seq_NCS_Mouse1.88045697
20EST1_17652178_ChIP-ChIP_JURKAT_Human1.82300263
21MYCN_18555785_ChIP-Seq_MESCs_Mouse1.80325874
22NELFA_20434984_ChIP-Seq_ESCs_Mouse1.79937764
23XRN2_22483619_ChIP-Seq_HELA_Human1.76441009
24SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.75020284
25FOXP3_21729870_ChIP-Seq_TREG_Human1.71989147
26BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.71884141
27FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.68602017
28CIITA_25753668_ChIP-Seq_RAJI_Human1.67645367
29MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.67445184
30* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.63632499
31NOTCH1_21737748_ChIP-Seq_TLL_Human1.59209531
32TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.56641567
33ESR1_15608294_ChIP-ChIP_MCF-7_Human1.55973791
34PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.55743383
35ETS1_20019798_ChIP-Seq_JURKAT_Human1.53783443
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51614839
37SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.51577088
38GABP_17652178_ChIP-ChIP_JURKAT_Human1.51329604
39CREB1_15753290_ChIP-ChIP_HEK293T_Human1.47424212
40KDM5A_27292631_Chip-Seq_BREAST_Human1.45882753
41KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.45773607
42TTF2_22483619_ChIP-Seq_HELA_Human1.43539147
43E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.43211256
44MYB_26560356_Chip-Seq_TH2_Human1.42869838
45STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.42273916
46JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.41850139
47IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.39654360
48CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.39217886
49DCP1A_22483619_ChIP-Seq_HELA_Human1.35940545
50GABP_19822575_ChIP-Seq_HepG2_Human1.33016437
51MYB_26560356_Chip-Seq_TH1_Human1.31645358
52FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.31205076
53VDR_21846776_ChIP-Seq_THP-1_Human1.29986232
54POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.27959761
55HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.27752599
56HOXB4_20404135_ChIP-ChIP_EML_Mouse1.27405103
57CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.26329607
58YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25533965
59E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.24652173
60ELK1_19687146_ChIP-ChIP_HELA_Human1.23091665
61SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.22591912
62FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.21400413
63STAT4_19710469_ChIP-ChIP_TH1__Mouse1.20408639
64ZFX_18555785_ChIP-Seq_MESCs_Mouse1.19198543
65SALL1_21062744_ChIP-ChIP_HESCs_Human1.17994802
66* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.17573918
67TP63_19390658_ChIP-ChIP_HaCaT_Human1.17050366
68NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.15739027
69SCL_19346495_ChIP-Seq_HPC-7_Human1.12235285
70POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.10958265
71NANOG_18555785_ChIP-Seq_MESCs_Mouse1.10880548
72FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.10793225
73MAF_26560356_Chip-Seq_TH1_Human1.09125989
74YY1_21170310_ChIP-Seq_MESCs_Mouse1.08539291
75ERG_20887958_ChIP-Seq_HPC-7_Mouse1.08140584
76UTX_26944678_Chip-Seq_JUKART_Human1.07619955
77NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.06677775
78* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.05723000
79TCF7_22412390_ChIP-Seq_EML_Mouse1.04666243
80SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.04577977
81E2F1_18555785_ChIP-Seq_MESCs_Mouse1.04564060
82SPI1_23547873_ChIP-Seq_NB4_Human1.04444726
83DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.04433342
84MYB_21317192_ChIP-Seq_ERMYB_Mouse1.04082610
85MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.03960862
86GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.02190384
87STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.98972031
88TFEB_21752829_ChIP-Seq_HELA_Human0.98733200
89THAP11_20581084_ChIP-Seq_MESCs_Mouse0.98657855
90KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.97892594
91EWS_26573619_Chip-Seq_HEK293_Human0.96942094
92SOX17_20123909_ChIP-Seq_XEN_Mouse0.96915695
93HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.96869964
94SOX2_16153702_ChIP-ChIP_HESCs_Human0.96610545
95CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.95440671
96SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.95189085
97PADI4_21655091_ChIP-ChIP_MCF-7_Human0.95000228
98ELF1_17652178_ChIP-ChIP_JURKAT_Human0.94818986
99CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.93896392
100SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.93309265
101NANOG_16153702_ChIP-ChIP_HESCs_Human0.92521187
102TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.92216670
103CHD1_26751641_Chip-Seq_LNCaP_Human0.90714954
104HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.90356343
105CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.90294797
106ZNF263_19887448_ChIP-Seq_K562_Human0.88349916
107RUNX1_22412390_ChIP-Seq_EML_Mouse0.87973410
108FUS_26573619_Chip-Seq_HEK293_Human0.87838312
109PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.87666059
110DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.87342205
111MYC_18940864_ChIP-ChIP_HL60_Human0.87327497
112ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.85336609
113* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.84949402
114KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.84941224
115MAF_26560356_Chip-Seq_TH2_Human0.84932876
116SRF_21415370_ChIP-Seq_HL-1_Mouse0.84134140
117CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.83510894
118PKCTHETA_26484144_Chip-Seq_BREAST_Human0.82423364
119HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.81384631
120FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.80757438
121SOX2_18555785_ChIP-Seq_MESCs_Mouse0.79746360
122GATA3_27048872_Chip-Seq_THYMUS_Human0.78313072
123BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.77680107
124BRD4_27068464_Chip-Seq_AML-cells_Mouse0.76768180
125NANOG_21062744_ChIP-ChIP_HESCs_Human0.76302691
126CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.74634422
127POU5F1_16153702_ChIP-ChIP_HESCs_Human0.74588976
128WT1_19549856_ChIP-ChIP_CCG9911_Human0.63788893
129POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.62853606

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.41852204
2MP0003693_abnormal_embryo_hatching4.07287807
3MP0008057_abnormal_DNA_replication3.96102804
4MP0003111_abnormal_nucleus_morphology3.84726035
5MP0008877_abnormal_DNA_methylation3.67069421
6MP0003077_abnormal_cell_cycle3.40438505
7MP0004957_abnormal_blastocyst_morpholog3.09971208
8MP0008058_abnormal_DNA_repair3.05756890
9MP0002396_abnormal_hematopoietic_system3.01009135
10MP0003763_abnormal_thymus_physiology2.62382542
11MP0005410_abnormal_fertilization2.51451541
12MP0008007_abnormal_cellular_replicative2.42813557
13MP0009697_abnormal_copulation2.40721189
14MP0004808_abnormal_hematopoietic_stem2.33139054
15MP0010307_abnormal_tumor_latency2.23050032
16MP0002398_abnormal_bone_marrow2.05745112
17MP0001929_abnormal_gametogenesis2.02133811
18MP0005671_abnormal_response_to2.01813314
19MP0000350_abnormal_cell_proliferation1.99692530
20MP0000685_abnormal_immune_system1.90999472
21MP0000703_abnormal_thymus_morphology1.90137558
22MP0001730_embryonic_growth_arrest1.83195912
23MP0010030_abnormal_orbit_morphology1.80319341
24MP0003937_abnormal_limbs/digits/tail_de1.78076282
25MP0008932_abnormal_embryonic_tissue1.76532876
26MP0001800_abnormal_humoral_immune1.75837012
27MP0010352_gastrointestinal_tract_polyps1.74137730
28MP0002210_abnormal_sex_determination1.73610471
29MP0002877_abnormal_melanocyte_morpholog1.71683911
30MP0000490_abnormal_crypts_of1.67341046
31MP0000689_abnormal_spleen_morphology1.64089104
32MP0003123_paternal_imprinting1.63392564
33MP0003698_abnormal_male_reproductive1.62194521
34MP0002722_abnormal_immune_system1.61676405
35MP0005397_hematopoietic_system_phenotyp1.58536237
36MP0001545_abnormal_hematopoietic_system1.58536237
37MP0004147_increased_porphyrin_level1.56372706
38MP0009333_abnormal_splenocyte_physiolog1.55764564
39MP0003787_abnormal_imprinting1.54180231
40MP0005076_abnormal_cell_differentiation1.53136802
41MP0000537_abnormal_urethra_morphology1.51434985
42MP0001145_abnormal_male_reproductive1.50136456
43MP0002102_abnormal_ear_morphology1.48123100
44MP0001697_abnormal_embryo_size1.47559663
45MP0002697_abnormal_eye_size1.46687159
46MP0000716_abnormal_immune_system1.45832549
47MP0003718_maternal_effect1.44612065
48MP0001835_abnormal_antigen_presentation1.41859210
49MP0002420_abnormal_adaptive_immunity1.41452874
50MP0001672_abnormal_embryogenesis/_devel1.40936751
51MP0005380_embryogenesis_phenotype1.40936751
52MP0002429_abnormal_blood_cell1.40815195
53MP0002019_abnormal_tumor_incidence1.38869191
54MP0001819_abnormal_immune_cell1.37926042
55MP0002452_abnormal_antigen_presenting1.37494287
56MP0003567_abnormal_fetal_cardiomyocyte1.36816010
57MP0000313_abnormal_cell_death1.35607503
58MP0000569_abnormal_digit_pigmentation1.33729382
59MP0000653_abnormal_sex_gland1.32648866
60MP0003121_genomic_imprinting1.32332025
61MP0002405_respiratory_system_inflammati1.31328830
62MP0003984_embryonic_growth_retardation1.28429175
63MP0002080_prenatal_lethality1.28222394
64MP0002723_abnormal_immune_serum1.27985533
65MP0002938_white_spotting1.26971302
66MP0002088_abnormal_embryonic_growth/wei1.24471265
67MP0003705_abnormal_hypodermis_morpholog1.23703277
68MP0002160_abnormal_reproductive_system1.23103565
69MP0001286_abnormal_eye_development1.21577356
70MP0003656_abnormal_erythrocyte_physiolo1.20916833
71MP0001790_abnormal_immune_system1.20600536
72MP0005387_immune_system_phenotype1.20600536
73MP0002653_abnormal_ependyma_morphology1.20496517
74MP0002086_abnormal_extraembryonic_tissu1.19166312
75MP0003786_premature_aging1.19123874
76MP0001346_abnormal_lacrimal_gland1.17189920
77MP0002085_abnormal_embryonic_tissue1.17099120
78MP0002084_abnormal_developmental_patter1.16001175
79MP0001873_stomach_inflammation1.15595168
80MP0003942_abnormal_urinary_system1.15407372
81MP0003385_abnormal_body_wall1.09749421
82MP0002166_altered_tumor_susceptibility1.09624161
83MP0005187_abnormal_penis_morphology1.09185165
84MP0002092_abnormal_eye_morphology1.07800380
85MP0002161_abnormal_fertility/fecundity1.07271517
86MP0005623_abnormal_meninges_morphology1.06322423
87MP0005000_abnormal_immune_tolerance1.06116157
88MP0003755_abnormal_palate_morphology1.06041755
89MP0009672_abnormal_birth_weight1.04108846
90MP0005171_absent_coat_pigmentation1.02176199
91MP0003861_abnormal_nervous_system1.02114903
92MP0000566_synostosis1.01500844
93MP0001188_hyperpigmentation1.01145137
94MP0000428_abnormal_craniofacial_morphol1.00858890
95MP0000372_irregular_coat_pigmentation0.98953213
96MP0003935_abnormal_craniofacial_develop0.97428952
97MP0008995_early_reproductive_senescence0.97372620
98MP0000049_abnormal_middle_ear0.97023775
99MP0002233_abnormal_nose_morphology0.96439213
100MP0003136_yellow_coat_color0.95344355
101MP0004197_abnormal_fetal_growth/weight/0.94420809
102MP0002111_abnormal_tail_morphology0.94275364
103MP0006292_abnormal_olfactory_placode0.94104384
104MP0002006_tumorigenesis0.94037111
105MP0005389_reproductive_system_phenotype0.92906244
106MP0002234_abnormal_pharynx_morphology0.92419266
107MP0009053_abnormal_anal_canal0.92362593
108MP0006054_spinal_hemorrhage0.89064604
109MP0003303_peritoneal_inflammation0.88813567
110MP0009703_decreased_birth_body0.88678341
111MP0005621_abnormal_cell_physiology0.88365557
112MP0002009_preneoplasia0.87944219
113MP0001119_abnormal_female_reproductive0.87552687
114MP0004185_abnormal_adipocyte_glucose0.87317220
115MP0003950_abnormal_plasma_membrane0.86389839
116MP0004233_abnormal_muscle_weight0.86350376
117MP0006035_abnormal_mitochondrial_morpho0.84024167
118MP0002249_abnormal_larynx_morphology0.82584394
119MP0005384_cellular_phenotype0.82211103
120MP0009379_abnormal_foot_pigmentation0.78651241
121MP0001661_extended_life_span0.78608793
122MP0002132_abnormal_respiratory_system0.78322067
123MP0005408_hypopigmentation0.77412668
124MP0003890_abnormal_embryonic-extraembry0.76946090
125MP0005310_abnormal_salivary_gland0.75828654
126MP0002114_abnormal_axial_skeleton0.75728395
127MP0000432_abnormal_head_morphology0.75436404
128MP0000678_abnormal_parathyroid_gland0.74124624
129MP0009250_abnormal_appendicular_skeleto0.73566559
130MP0005391_vision/eye_phenotype0.73474014
131MP0002081_perinatal_lethality0.73127663
132MP0003300_gastrointestinal_ulcer0.71906453
133MP0003448_altered_tumor_morphology0.71422265
134MP0009278_abnormal_bone_marrow0.71008999
135MP0005025_abnormal_response_to0.70753308
136MP0003119_abnormal_digestive_system0.70530753
137MP0000858_altered_metastatic_potential0.70424003
138MP0002163_abnormal_gland_morphology0.69538308
139MP0002177_abnormal_outer_ear0.69375167
140MP0001299_abnormal_eye_distance/0.67354934
141MP0002095_abnormal_skin_pigmentation0.66630717
142MP0000358_abnormal_cell_content/0.66626262
143MP0001293_anophthalmia0.66263825
144MP0003806_abnormal_nucleotide_metabolis0.65659308
145MP0003091_abnormal_cell_migration0.64959296
146MP0003699_abnormal_female_reproductive0.64389363
147MP0001915_intracranial_hemorrhage0.63891686
148MP0003943_abnormal_hepatobiliary_system0.62411422
149MP0009785_altered_susceptibility_to0.62050382
150MP0003315_abnormal_perineum_morphology0.61507701
151MP0008770_decreased_survivor_rate0.60945085
152MP0010155_abnormal_intestine_physiology0.60137315
153MP0005174_abnormal_tail_pigmentation0.59814884

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.61141993
2Reticulocytopenia (HP:0001896)3.68159283
3Chromsome breakage (HP:0040012)3.64756797
4Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.53496959
5Chromosomal breakage induced by crosslinking agents (HP:0003221)3.35622049
6Nasal polyposis (HP:0100582)3.20394833
7Recurrent bronchitis (HP:0002837)3.17916961
8Abnormality of chromosome stability (HP:0003220)3.12902673
9Dynein arm defect of respiratory motile cilia (HP:0012255)3.00461346
10Absent/shortened dynein arms (HP:0200106)3.00461346
11Volvulus (HP:0002580)2.99802703
12Aplasia/Hypoplasia of the uvula (HP:0010293)2.96785286
13Abnormality of the heme biosynthetic pathway (HP:0010472)2.94772439
14Medulloblastoma (HP:0002885)2.83051665
15Meckel diverticulum (HP:0002245)2.77630380
16Basal cell carcinoma (HP:0002671)2.74790407
17Abnormality of the preputium (HP:0100587)2.74648310
18Abnormality of the fingertips (HP:0001211)2.73842592
19Abnormality of the ileum (HP:0001549)2.67093705
20Myelodysplasia (HP:0002863)2.62897749
21Abnormal lung lobation (HP:0002101)2.62155637
22Breast hypoplasia (HP:0003187)2.62004014
23Bronchitis (HP:0012387)2.60626726
24Ependymoma (HP:0002888)2.59804659
25Duplication of thumb phalanx (HP:0009942)2.56874545
26IgM deficiency (HP:0002850)2.52152228
27Agnosia (HP:0010524)2.47349304
28Triphalangeal thumb (HP:0001199)2.46109548
29Small intestinal stenosis (HP:0012848)2.46038469
30Duodenal stenosis (HP:0100867)2.46038469
31Abnormality of the nasal mucosa (HP:0000433)2.44599769
32Aplasia/Hypoplasia of the sacrum (HP:0008517)2.44402413
33Ectopic kidney (HP:0000086)2.43940920
34Squamous cell carcinoma (HP:0002860)2.43548480
35Overlapping toe (HP:0001845)2.41083414
36Cortical dysplasia (HP:0002539)2.40807599
37Patellar aplasia (HP:0006443)2.38213419
38Impulsivity (HP:0100710)2.37319496
39Abnormality of cochlea (HP:0000375)2.33541937
40Abnormality of DNA repair (HP:0003254)2.32379025
41Aplastic anemia (HP:0001915)2.31470259
42Abnormal respiratory motile cilium physiology (HP:0012261)2.30956225
43Prominent nose (HP:0000448)2.29970102
44Lymphoma (HP:0002665)2.27943049
45Embryonal renal neoplasm (HP:0011794)2.24531504
46Duplicated collecting system (HP:0000081)2.22621383
47Arteriovenous malformation (HP:0100026)2.22392863
48Horseshoe kidney (HP:0000085)2.21841149
49Selective tooth agenesis (HP:0001592)2.21192478
50Cafe-au-lait spot (HP:0000957)2.21034082
51Abnormal respiratory motile cilium morphology (HP:0005938)2.20834686
52Abnormal respiratory epithelium morphology (HP:0012253)2.20834686
53Abnormality of the carotid arteries (HP:0005344)2.20264535
54Abnormal spermatogenesis (HP:0008669)2.19085843
55Abnormality of chromosome segregation (HP:0002916)2.18776895
56Recurrent sinusitis (HP:0011108)2.18673006
57Rhabdomyosarcoma (HP:0002859)2.17914080
58Bronchiectasis (HP:0002110)2.16609578
59Hypoplasia of the capital femoral epiphysis (HP:0003090)2.15675331
60Aplasia/Hypoplasia of the patella (HP:0006498)2.14606381
61Clubbing of toes (HP:0100760)2.14451277
62Short thumb (HP:0009778)2.13743944
63Increased nuchal translucency (HP:0010880)2.13661985
64Bone marrow hypocellularity (HP:0005528)2.13481425
65T lymphocytopenia (HP:0005403)2.13234038
66Sloping forehead (HP:0000340)2.12435060
67Rhinitis (HP:0012384)2.12425910
68Oral leukoplakia (HP:0002745)2.07057993
69High anterior hairline (HP:0009890)2.05080260
70Aplasia/Hypoplasia of the sternum (HP:0006714)2.03588788
71Leukopenia (HP:0001882)2.02445292
72Poikilocytosis (HP:0004447)2.00226509
73Abnormality of T cell number (HP:0011839)2.00216979
74High pitched voice (HP:0001620)1.97761377
75Short middle phalanx of the 5th finger (HP:0004220)1.97492488
76Panhypogammaglobulinemia (HP:0003139)1.97004707
77Cleft eyelid (HP:0000625)1.96810000
78Abnormality of glycolysis (HP:0004366)1.95974519
79Nephronophthisis (HP:0000090)1.95035465
80Absent thumb (HP:0009777)1.94757109
81Facial cleft (HP:0002006)1.94340555
82Morphological abnormality of the inner ear (HP:0011390)1.93105320
83Choanal atresia (HP:0000453)1.93015620
84Abnormality of the duodenum (HP:0002246)1.92758971
85Supernumerary spleens (HP:0009799)1.90605889
8611 pairs of ribs (HP:0000878)1.90071514
87Absent radius (HP:0003974)1.90058417
88Abnormality of the labia minora (HP:0012880)1.89399069
89Abnormality of T cells (HP:0002843)1.88579066
90Acute myeloid leukemia (HP:0004808)1.88502511
91Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.87593584
92Short 4th metacarpal (HP:0010044)1.87593584
93Abnormal number of incisors (HP:0011064)1.87374973
94Abnormality of the phalanges of the hallux (HP:0010057)1.86500172
95Abnormality of the renal collecting system (HP:0004742)1.85921712
96Cellular immunodeficiency (HP:0005374)1.85560718
97Facial hemangioma (HP:0000329)1.85023374
98B lymphocytopenia (HP:0010976)1.84966398
99Abnormality of B cell number (HP:0010975)1.84966398
100Atresia of the external auditory canal (HP:0000413)1.84713023
101IgG deficiency (HP:0004315)1.84590422
102Abnormality of reticulocytes (HP:0004312)1.84277535
103Cutaneous melanoma (HP:0012056)1.84231390
104Abnormality of the astrocytes (HP:0100707)1.83088751
105Astrocytoma (HP:0009592)1.83088751
106Abnormal number of erythroid precursors (HP:0012131)1.82905806
107Macrocytic anemia (HP:0001972)1.82515989
108Amaurosis fugax (HP:0100576)1.82384552
109Neoplasm of striated muscle (HP:0009728)1.80589569
110Small hand (HP:0200055)1.79635523
111Glioma (HP:0009733)1.79495273
112Colon cancer (HP:0003003)1.78853202
113Poikiloderma (HP:0001029)1.78676850
114Progressive muscle weakness (HP:0003323)1.78666194
115Recurrent viral infections (HP:0004429)1.78500143
116Thrombocytosis (HP:0001894)1.77857629
117Proximal placement of thumb (HP:0009623)1.77551608
118Abnormality of the anterior horn cell (HP:0006802)1.76814515
119Degeneration of anterior horn cells (HP:0002398)1.76814515
120Aplasia involving forearm bones (HP:0009822)1.76212487
121Absent forearm bone (HP:0003953)1.76212487
122Skull defect (HP:0001362)1.76101877
123Abnormality of cells of the erythroid lineage (HP:0012130)1.76075690
124Deviation of the thumb (HP:0009603)1.75759227
125Microtia (HP:0008551)1.75233137
126Nephroblastoma (Wilms tumor) (HP:0002667)1.75134680
127Chronic bronchitis (HP:0004469)1.74691373
128Embryonal neoplasm (HP:0002898)1.74126470
129Recurrent otitis media (HP:0000403)1.73886412
130Acute lymphatic leukemia (HP:0006721)1.73614453
131Pulmonary fibrosis (HP:0002206)1.73550177
132Abnormality of midbrain morphology (HP:0002418)1.72039750
133Pallor (HP:0000980)1.72032840
134Microvesicular hepatic steatosis (HP:0001414)1.71515588
135Increased serum pyruvate (HP:0003542)1.69526043
136Obsessive-compulsive behavior (HP:0000722)1.68873977
137Capillary hemangiomas (HP:0005306)1.68193514
138Microglossia (HP:0000171)1.65444402
139Deep philtrum (HP:0002002)1.64804373
140Cerebellar dysplasia (HP:0007033)1.64022365
141Neoplasm of the colon (HP:0100273)1.61150492
142Hypoplasia of the pons (HP:0012110)1.56019300
143Coronal craniosynostosis (HP:0004440)1.54897001
144Diastasis recti (HP:0001540)1.54335642
145Missing ribs (HP:0000921)1.54291008
146Septate vagina (HP:0001153)1.53329224
147Ulnar bowing (HP:0003031)1.50270901
148External ear malformation (HP:0008572)1.47392088
149Long clavicles (HP:0000890)1.46659209
150Facial asymmetry (HP:0000324)1.46047962
151Retinal dysplasia (HP:0007973)1.45781104
152Absent epiphyses (HP:0010577)1.45296209
153Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.45296209
154Ureteral duplication (HP:0000073)1.44744006

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.73353754
2WEE13.94549253
3NEK23.19950208
4MAP4K12.88116376
5ACVR1B2.51490744
6CDK122.42640294
7NEK12.34772759
8BRSK22.23090775
9STK102.20883744
10PLK42.19320947
11PBK2.09072828
12BUB11.94322365
13TAF11.94262432
14PDK31.94107172
15PDK41.94107172
16EIF2AK11.91722016
17MAP3K101.91684169
18RPS6KA41.91083749
19TXK1.83945177
20DYRK31.81389618
21ATR1.79804683
22TTK1.76692600
23VRK11.71098193
24CHEK21.69228787
25SRPK11.67355716
26PLK11.60914175
27CDK41.52304427
28CCNB11.49175521
29GRK61.48922871
30EEF2K1.48754274
31LATS11.45541864
32CHEK11.45418780
33BRD41.43730102
34TSSK61.40970303
35MAP3K131.36449742
36BRSK11.35026606
37AURKB1.33588668
38TESK21.28511185
39PIM11.26428426
40MELK1.23340413
41SCYL21.19695544
42VRK21.17801443
43MAP3K81.15397009
44TRIM281.13156571
45CDK71.12554644
46JAK31.12222942
47ATM1.10211053
48PNCK1.08459628
49PASK1.05236580
50TLK11.04160167
51PLK31.03018706
52SMG11.01863823
53STK30.99267420
54ITK0.97594741
55CAMK1G0.96639703
56EIF2AK30.95172283
57MKNK10.93811326
58MARK30.91056326
59BRAF0.90546278
60MAP3K140.89874827
61ALK0.88833093
62CDK20.87650118
63TEC0.86610977
64ZAP700.84556705
65LATS20.82544513
66STK40.81488283
67BTK0.81251504
68AURKA0.80948758
69RPS6KB20.77952119
70STK160.76135137
71ZAK0.74993907
72TESK10.72793053
73SYK0.72235109
74CLK10.71677341
75CDK80.70516666
76TYK20.69869540
77EIF2AK20.66122596
78ICK0.66065292
79PDK20.64887921
80CDK30.64600768
81TAOK10.64301342
82PLK20.63952930
83CDK60.62005608
84CAMK1D0.61626877
85BCR0.61577185
86RPS6KA50.61559974
87CDK10.61393864
88NUAK10.60812464
89LRRK20.59388741
90STK38L0.58901430
91MAP2K30.58689377
92LCK0.58682464
93KSR10.58381624
94KSR20.58111694
95CSF1R0.57875881
96STK240.57158667
97CDK11A0.55004282
98AKT20.53552874
99CDK180.53465972
100CDK150.53262734
101NME10.52389085
102CDK90.52373527
103DYRK20.50796879
104CSNK1G10.50098750
105CSNK1E0.49106697
106ERBB40.48907276
107MET0.48579210
108CDK140.47185371
109RIPK40.46644312
110FGFR10.46363923
111IKBKB0.46173992
112LYN0.45416943
113SIK20.43900450
114NLK0.43181172
115CSNK1A1L0.42838695
116PINK10.42678708
117CSNK1G30.42530598
118MKNK20.42517662
119CHUK0.41942454
120CSNK2A20.40526659
121RAF10.40183573
122MST1R0.39895405
123NME20.39238674
124PRKDC0.38069876
125TNIK0.37898594
126PTK2B0.37466339
127MTOR0.37389687
128DAPK10.37241313
129STK390.36638951
130PAK40.36190199
131ERBB30.35473674
132MAP3K60.35343210
133MAPK140.35287408
134BMPR20.33342021
135CAMKK20.32736569
136MAP3K90.32584436
137CSNK2A10.31552368
138HCK0.30879201
139MAPK100.30561694
140TGFBR10.30556326
141KIT0.26370675
142PDK10.26192529
143PAK10.25568924

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.45094111
2Mismatch repair_Homo sapiens_hsa034303.66656204
3Cell cycle_Homo sapiens_hsa041102.78045896
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.55262726
5Fanconi anemia pathway_Homo sapiens_hsa034602.48786233
6Homologous recombination_Homo sapiens_hsa034402.47776334
7Base excision repair_Homo sapiens_hsa034102.45161893
8Spliceosome_Homo sapiens_hsa030402.42019286
9RNA transport_Homo sapiens_hsa030132.38467763
10Nucleotide excision repair_Homo sapiens_hsa034202.31471283
11Basal transcription factors_Homo sapiens_hsa030221.99962134
12RNA degradation_Homo sapiens_hsa030181.89907505
13mRNA surveillance pathway_Homo sapiens_hsa030151.77284676
14Primary immunodeficiency_Homo sapiens_hsa053401.75642660
15Non-homologous end-joining_Homo sapiens_hsa034501.74764310
16One carbon pool by folate_Homo sapiens_hsa006701.56848267
17Pyrimidine metabolism_Homo sapiens_hsa002401.55380821
18Antigen processing and presentation_Homo sapiens_hsa046121.53335472
19p53 signaling pathway_Homo sapiens_hsa041151.52702750
20Protein export_Homo sapiens_hsa030601.47331915
21Herpes simplex infection_Homo sapiens_hsa051681.44656743
22Oocyte meiosis_Homo sapiens_hsa041141.37123348
23Systemic lupus erythematosus_Homo sapiens_hsa053221.36521652
24T cell receptor signaling pathway_Homo sapiens_hsa046601.35923362
25RNA polymerase_Homo sapiens_hsa030201.33917743
26Biosynthesis of amino acids_Homo sapiens_hsa012301.32397011
27B cell receptor signaling pathway_Homo sapiens_hsa046621.30949611
28Selenocompound metabolism_Homo sapiens_hsa004501.27499358
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.27108884
30Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.26384167
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.26256586
32Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.24006735
33Epstein-Barr virus infection_Homo sapiens_hsa051691.22602064
34Viral carcinogenesis_Homo sapiens_hsa052031.20517899
35Measles_Homo sapiens_hsa051621.15538130
36Ribosome_Homo sapiens_hsa030101.12728677
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.12589006
38HTLV-I infection_Homo sapiens_hsa051661.10529677
39NF-kappa B signaling pathway_Homo sapiens_hsa040641.08863934
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.05707365
41Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.02848130
42Sulfur relay system_Homo sapiens_hsa041221.02711395
43Proteasome_Homo sapiens_hsa030501.01781832
44Folate biosynthesis_Homo sapiens_hsa007900.99685666
45Pyruvate metabolism_Homo sapiens_hsa006200.99616980
46Lysine degradation_Homo sapiens_hsa003100.99515067
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.98875200
48Intestinal immune network for IgA production_Homo sapiens_hsa046720.96965117
49Hepatitis B_Homo sapiens_hsa051610.95409581
50Chronic myeloid leukemia_Homo sapiens_hsa052200.91782228
51Purine metabolism_Homo sapiens_hsa002300.91738273
52Hematopoietic cell lineage_Homo sapiens_hsa046400.91622137
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.88468170
54Small cell lung cancer_Homo sapiens_hsa052220.86410843
55Carbon metabolism_Homo sapiens_hsa012000.85958523
56Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.85098206
57Basal cell carcinoma_Homo sapiens_hsa052170.84759023
58Hippo signaling pathway_Homo sapiens_hsa043900.84514623
59Colorectal cancer_Homo sapiens_hsa052100.81448353
60Hedgehog signaling pathway_Homo sapiens_hsa043400.81382961
61Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.80856109
62Steroid biosynthesis_Homo sapiens_hsa001000.79947135
63Shigellosis_Homo sapiens_hsa051310.78849832
64Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.78556461
65Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78336614
66MicroRNAs in cancer_Homo sapiens_hsa052060.77481044
67Alcoholism_Homo sapiens_hsa050340.76553104
68Allograft rejection_Homo sapiens_hsa053300.76515261
69Pancreatic cancer_Homo sapiens_hsa052120.76124344
70Osteoclast differentiation_Homo sapiens_hsa043800.73355736
712-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.73061260
72Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.72583770
73Autoimmune thyroid disease_Homo sapiens_hsa053200.72238372
74Apoptosis_Homo sapiens_hsa042100.72166612
75Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.71633276
76Jak-STAT signaling pathway_Homo sapiens_hsa046300.69001067
77Propanoate metabolism_Homo sapiens_hsa006400.66705942
78Non-small cell lung cancer_Homo sapiens_hsa052230.66569616
79Leishmaniasis_Homo sapiens_hsa051400.66267272
80Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.66009991
81VEGF signaling pathway_Homo sapiens_hsa043700.65568713
82Influenza A_Homo sapiens_hsa051640.64944939
83Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.63982009
84NOD-like receptor signaling pathway_Homo sapiens_hsa046210.63155056
85Huntingtons disease_Homo sapiens_hsa050160.63146093
86Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.62718187
87Wnt signaling pathway_Homo sapiens_hsa043100.62573199
88Vitamin B6 metabolism_Homo sapiens_hsa007500.62287033
89Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.62017253
90Acute myeloid leukemia_Homo sapiens_hsa052210.61815166
91Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60254850
92Melanoma_Homo sapiens_hsa052180.58369100
93Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55113279
94Fatty acid elongation_Homo sapiens_hsa000620.54567762
95Legionellosis_Homo sapiens_hsa051340.54504881
96Prolactin signaling pathway_Homo sapiens_hsa049170.53682336
97Bladder cancer_Homo sapiens_hsa052190.53329309
98Parkinsons disease_Homo sapiens_hsa050120.51969918
99mTOR signaling pathway_Homo sapiens_hsa041500.51816138
100FoxO signaling pathway_Homo sapiens_hsa040680.51700110
101TNF signaling pathway_Homo sapiens_hsa046680.50881341
102Toxoplasmosis_Homo sapiens_hsa051450.50784003
103Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49413659
104Prostate cancer_Homo sapiens_hsa052150.49220939
105Adherens junction_Homo sapiens_hsa045200.48514987
106Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.47963342
107MAPK signaling pathway_Homo sapiens_hsa040100.47364135
108Neurotrophin signaling pathway_Homo sapiens_hsa047220.47258607
109N-Glycan biosynthesis_Homo sapiens_hsa005100.46409492
110RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.45699870
111Long-term potentiation_Homo sapiens_hsa047200.45054391
112Dorso-ventral axis formation_Homo sapiens_hsa043200.44454590
113Chemokine signaling pathway_Homo sapiens_hsa040620.43326735
114Asthma_Homo sapiens_hsa053100.43274447
115Inositol phosphate metabolism_Homo sapiens_hsa005620.42608041
116Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41478532
117Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41092133
118Glioma_Homo sapiens_hsa052140.36963795
119Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36876891
120Pentose phosphate pathway_Homo sapiens_hsa000300.36500559
121Viral myocarditis_Homo sapiens_hsa054160.36384361
122Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.36288765
123Circadian rhythm_Homo sapiens_hsa047100.34739587
124TGF-beta signaling pathway_Homo sapiens_hsa043500.34571831
125Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.34534560
126Platelet activation_Homo sapiens_hsa046110.32785703
127Thyroid cancer_Homo sapiens_hsa052160.32232029
128Glutathione metabolism_Homo sapiens_hsa004800.32112942
129Choline metabolism in cancer_Homo sapiens_hsa052310.31495854
130HIF-1 signaling pathway_Homo sapiens_hsa040660.31321656
131Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.31098249
132AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.30617746
133Metabolic pathways_Homo sapiens_hsa011000.29946793
134Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29876017
135Pathways in cancer_Homo sapiens_hsa052000.29784806
136Central carbon metabolism in cancer_Homo sapiens_hsa052300.29252917
137Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.27473176
138Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.26924407
139Fructose and mannose metabolism_Homo sapiens_hsa000510.26293696
140Arginine biosynthesis_Homo sapiens_hsa002200.25059785
141Oxidative phosphorylation_Homo sapiens_hsa001900.23253808
142Fatty acid metabolism_Homo sapiens_hsa012120.22402310
143Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.21964355
144Melanogenesis_Homo sapiens_hsa049160.20505674
145Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.19269149
146Cyanoamino acid metabolism_Homo sapiens_hsa004600.18695900
147Arginine and proline metabolism_Homo sapiens_hsa003300.14948677
148Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.14633646

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