DOPEY2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)4.93688594
2proline transport (GO:0015824)4.17117542
3regulation of short-term neuronal synaptic plasticity (GO:0048172)3.89835288
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.42268502
5response to dietary excess (GO:0002021)3.42207283
6locomotory exploration behavior (GO:0035641)3.42187659
7sodium ion export (GO:0071436)3.32824495
8histone H3-K4 trimethylation (GO:0080182)3.27919813
9iron ion import (GO:0097286)3.26723667
10cellular potassium ion homeostasis (GO:0030007)3.22019309
11positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.22017838
12glutamate secretion (GO:0014047)3.21763076
13vocalization behavior (GO:0071625)3.20734404
14positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.18869724
15intestinal epithelial cell development (GO:0060576)3.13753973
16synaptic vesicle exocytosis (GO:0016079)3.07943765
17cellular response to ethanol (GO:0071361)3.07943406
18hormone catabolic process (GO:0042447)3.04532799
19carnitine shuttle (GO:0006853)3.03764720
20daunorubicin metabolic process (GO:0044597)2.98071441
21polyketide metabolic process (GO:0030638)2.98071441
22doxorubicin metabolic process (GO:0044598)2.98071441
23detection of temperature stimulus (GO:0016048)2.97361752
24layer formation in cerebral cortex (GO:0021819)2.95752127
25negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.93087057
26myeloid leukocyte mediated immunity (GO:0002444)2.91222927
27regulation of synaptic vesicle exocytosis (GO:2000300)2.90575073
28gamma-aminobutyric acid transport (GO:0015812)2.88664468
29carnitine transmembrane transport (GO:1902603)2.85760339
30fatty acid transmembrane transport (GO:1902001)2.84346289
31regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.82054174
32nerve growth factor signaling pathway (GO:0038180)2.79443220
33neurotransmitter secretion (GO:0007269)2.78114501
34protein targeting to Golgi (GO:0000042)2.76948061
35regulation of fatty acid beta-oxidation (GO:0031998)2.76789811
36cerebellar Purkinje cell differentiation (GO:0021702)2.76733512
37branching involved in prostate gland morphogenesis (GO:0060442)2.76329625
38carnitine transport (GO:0015879)2.74840477
39amino-acid betaine transport (GO:0015838)2.74840477
40coenzyme catabolic process (GO:0009109)2.74212733
41ionotropic glutamate receptor signaling pathway (GO:0035235)2.68725414
42positive regulation of macrophage cytokine production (GO:0060907)2.67184341
43regulation of ARF protein signal transduction (GO:0032012)2.66655714
44cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.66311888
45maintenance of protein location in nucleus (GO:0051457)2.66220508
46cellular modified amino acid catabolic process (GO:0042219)2.64385918
47regulation of glutamate receptor signaling pathway (GO:1900449)2.63927074
48glycine transport (GO:0015816)2.62178860
49neurotransmitter-gated ion channel clustering (GO:0072578)2.61784350
50cerebellar granule cell differentiation (GO:0021707)2.59290588
51striated muscle atrophy (GO:0014891)2.58968243
52positive regulation of fatty acid beta-oxidation (GO:0032000)2.58172600
53regulation of synaptic vesicle transport (GO:1902803)2.57132088
54establishment of protein localization to Golgi (GO:0072600)2.56621433
55regulation of neuronal synaptic plasticity (GO:0048168)2.54779909
56biotin metabolic process (GO:0006768)2.54624811
57positive regulation of synapse maturation (GO:0090129)2.53866273
58regulation of synapse structural plasticity (GO:0051823)2.52871058
59opsonization (GO:0008228)2.52465596
60early endosome to late endosome transport (GO:0045022)2.51505303
61glutamate receptor signaling pathway (GO:0007215)2.50872767
62neuronal action potential propagation (GO:0019227)2.50451993
63synaptic vesicle endocytosis (GO:0048488)2.50305428
64alanine transport (GO:0032328)2.49944047
65skeletal muscle adaptation (GO:0043501)2.49894306
66synaptic transmission, glutamatergic (GO:0035249)2.48109454
67synaptic vesicle docking involved in exocytosis (GO:0016081)2.47066524
68auditory receptor cell differentiation (GO:0042491)2.45455426
69membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.45313147
70cytoskeletal anchoring at plasma membrane (GO:0007016)2.44563085
71neuromuscular process controlling balance (GO:0050885)2.41757986
72dendrite morphogenesis (GO:0048813)2.40606562
73L-amino acid import (GO:0043092)2.40226074
74histone H3-K36 demethylation (GO:0070544)2.39773351
75retrograde transport, vesicle recycling within Golgi (GO:0000301)2.39560802
76regulation of gamma-delta T cell activation (GO:0046643)2.39538203
77interkinetic nuclear migration (GO:0022027)2.38958561
78neurotransmitter transport (GO:0006836)2.38680247
79exploration behavior (GO:0035640)2.38662164
80protein localization to synapse (GO:0035418)2.38381481
81cellular sodium ion homeostasis (GO:0006883)2.38370744
82regulation of long-term neuronal synaptic plasticity (GO:0048169)2.37939245
83positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.36255949
84positive regulation of fatty acid oxidation (GO:0046321)2.35478113
85lysosome organization (GO:0007040)2.35367298
86lytic vacuole organization (GO:0080171)2.35367298
87membrane depolarization during action potential (GO:0086010)2.34980000
88lipid translocation (GO:0034204)2.34866571
89phospholipid translocation (GO:0045332)2.34866571
90regulation of macrophage cytokine production (GO:0010935)2.34390958
91detection of temperature stimulus involved in sensory perception (GO:0050961)2.33591591
92detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.33591591
93regulation of gamma-delta T cell differentiation (GO:0045586)2.33227346
94cell communication by electrical coupling (GO:0010644)2.31327745
95defense response to fungus (GO:0050832)2.30929108
96lung epithelial cell differentiation (GO:0060487)2.30877893
97activation of protein kinase A activity (GO:0034199)2.30528344
98somite rostral/caudal axis specification (GO:0032525)2.29181475
99peptidyl-lysine trimethylation (GO:0018023)2.29053806
100import into cell (GO:0098657)2.28879828
101regulation of Rap GTPase activity (GO:0032317)2.28878892
102positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.28402287
103vesicle transport along microtubule (GO:0047496)2.27866909
104positive regulation of Rap GTPase activity (GO:0032854)2.27297184
105potassium ion import (GO:0010107)2.26897476
106long-term memory (GO:0007616)2.26033996
107macroautophagy (GO:0016236)2.25945555
108histone H3-K4 methylation (GO:0051568)2.25525478
109regulation of receptor binding (GO:1900120)2.25416926
110mannose metabolic process (GO:0006013)2.25348946
111neuromuscular process controlling posture (GO:0050884)2.25169222
112positive regulation of gamma-delta T cell activation (GO:0046645)2.24790388
113L-fucose metabolic process (GO:0042354)2.24502114
114L-fucose catabolic process (GO:0042355)2.24502114
115fucose catabolic process (GO:0019317)2.24502114
116mitochondrion distribution (GO:0048311)2.24264485
117epithelial cell maturation (GO:0002070)2.23888730
118positive regulation of steroid hormone secretion (GO:2000833)2.22868621
119sulfur amino acid catabolic process (GO:0000098)2.22419577
120cellular extravasation (GO:0045123)2.22246929
121negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.20772219
122positive regulation of bone remodeling (GO:0046852)2.20693419
123positive regulation of bone resorption (GO:0045780)2.20693419
124response to lipoprotein particle (GO:0055094)2.20600376
125striatum development (GO:0021756)2.20543542
126macrophage activation involved in immune response (GO:0002281)2.20228720
127G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.20061883
128potassium ion homeostasis (GO:0055075)2.20001883
129neutral amino acid transport (GO:0015804)2.19450961
130activated T cell proliferation (GO:0050798)2.18897897
131calcium-mediated signaling using intracellular calcium source (GO:0035584)2.18815532
132regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.18630068
133regulation of fatty acid oxidation (GO:0046320)2.18444343
134peptidyl-tyrosine autophosphorylation (GO:0038083)2.17157444
135neuron-neuron synaptic transmission (GO:0007270)2.17105846
136regulation of beta-amyloid formation (GO:1902003)2.16777869
137regulation of cholesterol homeostasis (GO:2000188)2.16598982
138cell migration in hindbrain (GO:0021535)2.16169855
139lung cell differentiation (GO:0060479)2.15328648
140quaternary ammonium group transport (GO:0015697)2.14598866
141cell communication involved in cardiac conduction (GO:0086065)2.14427907
142dendritic spine morphogenesis (GO:0060997)2.13739347
143phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.13703032
144regulation of dendritic spine morphogenesis (GO:0061001)2.13558655
145insulin-like growth factor receptor signaling pathway (GO:0048009)2.13224117
146response to auditory stimulus (GO:0010996)2.13109998
147regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.12868454
148regulation of response to osmotic stress (GO:0047484)2.12591243
149regulation of neurotransmitter levels (GO:0001505)2.12356806
150transmission of nerve impulse (GO:0019226)2.12072123
151organelle transport along microtubule (GO:0072384)2.12032750
152cell differentiation in hindbrain (GO:0021533)2.10762429
153regulation of synaptic transmission, glutamatergic (GO:0051966)2.10744451
154sulfate transmembrane transport (GO:1902358)2.09995576
155positive regulation of histone deacetylation (GO:0031065)2.09283229
156piRNA metabolic process (GO:0034587)2.08847145
157regulation of ARF GTPase activity (GO:0032312)2.08377540
158nitric oxide biosynthetic process (GO:0006809)2.08337967
159regulation of MHC class I biosynthetic process (GO:0045343)2.07896700
160response to peptidoglycan (GO:0032494)2.06697142
161negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.06580982
162negative regulation of cell killing (GO:0031342)2.06580982
163regulation of protein polyubiquitination (GO:1902914)2.05943222
164protein targeting to lysosome (GO:0006622)2.05940824
165establishment of protein localization to vacuole (GO:0072666)2.05940824
166protein targeting to vacuole (GO:0006623)2.05940824
167regulation of clathrin-mediated endocytosis (GO:2000369)2.03952615
168histone lysine methylation (GO:0034968)2.02781036
169positive regulation of CREB transcription factor activity (GO:0032793)2.00906215
170regulation of interleukin-12 biosynthetic process (GO:0045075)2.00458721
171phospholipid dephosphorylation (GO:0046839)2.00125987
172artery development (GO:0060840)1.98775951
173peptidyl-lysine methylation (GO:0018022)1.98211539
174phosphatidylinositol dephosphorylation (GO:0046856)1.97433723
175positive regulation of mast cell activation (GO:0033005)1.96832429
176neutrophil activation (GO:0042119)1.96276638
177regulation of establishment of cell polarity (GO:2000114)1.94139603
178mitochondrion degradation (GO:0000422)1.93415680
179melanocyte differentiation (GO:0030318)1.92977926
180pharyngeal system development (GO:0060037)1.91561211
181regulation of mast cell activation (GO:0033003)1.90838309
182intracellular lipid transport (GO:0032365)1.90147247
183muscle atrophy (GO:0014889)1.89844497
184positive regulation of macroautophagy (GO:0016239)1.89316089
185detection of molecule of bacterial origin (GO:0032490)1.88412906
186regulation of cilium assembly (GO:1902017)1.88258912
187regulation of hippo signaling (GO:0035330)1.87717564
188negative regulation of macrophage differentiation (GO:0045650)1.87540593
189positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)1.86729460
190oligosaccharide catabolic process (GO:0009313)1.85852989
191production of molecular mediator involved in inflammatory response (GO:0002532)1.85652199
192regulation of establishment or maintenance of cell polarity (GO:0032878)1.85479438
193negative regulation of fatty acid transport (GO:2000192)1.85211800

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human2.50687427
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.47878770
3EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.31620478
4IRF8_22096565_ChIP-ChIP_GC-B_Human2.22665572
5BP1_19119308_ChIP-ChIP_Hs578T_Human2.17526953
6* PIAS1_25552417_ChIP-Seq_VCAP_Human2.06633313
7RARB_27405468_Chip-Seq_BRAIN_Mouse2.05488782
8DROSHA_22980978_ChIP-Seq_HELA_Human2.04462408
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.01611137
10* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.99499926
11IKZF1_21737484_ChIP-ChIP_HCT116_Human1.98695704
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.94997430
13* REST_21632747_ChIP-Seq_MESCs_Mouse1.93010928
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.89682377
15ESR1_21235772_ChIP-Seq_MCF-7_Human1.88608549
16MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.84320650
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.82332736
18THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.78207195
19* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.77727464
20* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.77340290
21* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.77340290
22* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.76947798
23* KDM2B_26808549_Chip-Seq_K562_Human1.69216986
24* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.68383238
25KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.67190644
26KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.67190644
27KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.67190644
28VDR_24787735_ChIP-Seq_THP-1_Human1.65901084
29JARID2_20075857_ChIP-Seq_MESCs_Mouse1.61969752
30REST_18959480_ChIP-ChIP_MESCs_Mouse1.60243734
31JARID2_20064375_ChIP-Seq_MESCs_Mouse1.58893464
32GBX2_23144817_ChIP-Seq_PC3_Human1.54184257
33SCL_19346495_ChIP-Seq_HPC-7_Human1.53962868
34SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.51598758
35SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.50496838
36RNF2_27304074_Chip-Seq_ESCs_Mouse1.49965817
37IRF8_27001747_Chip-Seq_BMDM_Mouse1.49359315
38AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.49181433
39VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.49082145
40EZH2_27294783_Chip-Seq_ESCs_Mouse1.47186245
41* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.46987736
42* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.45645056
43KDM2B_26808549_Chip-Seq_SUP-B15_Human1.42358409
44SUZ12_27294783_Chip-Seq_ESCs_Mouse1.42182426
45AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.39307005
46* ESR2_21235772_ChIP-Seq_MCF-7_Human1.37601220
47* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.36220690
48* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.35314546
49GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.34495602
50ERG_21242973_ChIP-ChIP_JURKAT_Human1.34319623
51* FOXA1_25552417_ChIP-Seq_VCAP_Human1.33519941
52GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32715759
53DNAJC2_21179169_ChIP-ChIP_NT2_Human1.31000630
54AHR_22903824_ChIP-Seq_MCF-7_Human1.30353388
55FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.29685585
56WT1_25993318_ChIP-Seq_PODOCYTE_Human1.29491442
57FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.28000662
58ER_23166858_ChIP-Seq_MCF-7_Human1.27830193
59* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.27612247
60SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.27551287
61* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.25705697
62* LXR_22158963_ChIP-Seq_LIVER_Mouse1.25294806
63RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.23886165
64RUNX_20019798_ChIP-Seq_JUKART_Human1.23472797
65RUNX1_27514584_Chip-Seq_MCF-7_Human1.22654325
66ZFP281_27345836_Chip-Seq_ESCs_Mouse1.22165756
67WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.21812413
68GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17390822
69CDX2_20551321_ChIP-Seq_CACO-2_Human1.16318015
70* RXR_22158963_ChIP-Seq_LIVER_Mouse1.15876467
71EZH2_27304074_Chip-Seq_ESCs_Mouse1.15497142
72ARNT_22903824_ChIP-Seq_MCF-7_Human1.14314995
73IRF8_21731497_ChIP-ChIP_J774_Mouse1.13338462
74ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.12472792
75SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.10614926
76FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.08890613
77* GATA1_19941827_ChIP-Seq_MEL_Mouse1.08725175
78SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08569084
79* LXR_22292898_ChIP-Seq_THP-1_Human1.07724567
80* ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.06806452
81SMAD3_21741376_ChIP-Seq_HESCs_Human1.06724521
82ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06578077
83GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06282213
84VDR_24763502_ChIP-Seq_THP-1_Human1.05571824
85FOXO3_23340844_ChIP-Seq_DLD1_Human1.05264021
86AR_19668381_ChIP-Seq_PC3_Human1.04941358
87* FOXA2_19822575_ChIP-Seq_HepG2_Human1.02485995
88EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.02217266
89IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.00598534
90SMC4_20622854_ChIP-Seq_HELA_Human1.00149939
91SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.99764043
92* SOX2_21211035_ChIP-Seq_LN229_Gbm0.99657885
93TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99654641
94TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98731589
95POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98731589
96* SMAD4_21741376_ChIP-Seq_HESCs_Human0.98692647
97* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.98358521
98PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97797941
99NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.97033331
100RING1B_27294783_Chip-Seq_NPCs_Mouse0.95213776
101TCF7_22412390_ChIP-Seq_EML_Mouse0.94646317
102ZNF274_21170338_ChIP-Seq_K562_Hela0.94641486
103GATA2_21666600_ChIP-Seq_HMVEC_Human0.94519178
104AR_25329375_ChIP-Seq_VCAP_Human0.94129840
105* OCT1_27270436_Chip-Seq_PROSTATE_Human0.94055950
106FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.93909946
107* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.93509233
108ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.93180876
109CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.93165649
110TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.93147763
111CTNNB1_20460455_ChIP-Seq_HCT116_Human0.92946058
112* STAT3_23295773_ChIP-Seq_U87_Human0.92853092
113RING1B_27294783_Chip-Seq_ESCs_Mouse0.92819650
114RXR_22108803_ChIP-Seq_LS180_Human0.92521702
115MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.92220244
116EED_16625203_ChIP-ChIP_MESCs_Mouse0.92171073
117STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.92061633
118TCF4_23295773_ChIP-Seq_U87_Human0.91860162
119* PPARA_22158963_ChIP-Seq_LIVER_Mouse0.90913476
120NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90144671
121E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.89852260
122TET1_21490601_ChIP-Seq_MESCs_Mouse0.89032773
123* KDM2B_26808549_Chip-Seq_DND41_Human0.88647782
124ELK4_26923725_Chip-Seq_MESODERM_Mouse0.88457951
125SOX9_24532713_ChIP-Seq_HFSC_Mouse0.87431928
126CDX2_19796622_ChIP-Seq_MESCs_Mouse0.87394551
127P53_22127205_ChIP-Seq_FIBROBLAST_Human0.86990363
128SMAD4_21799915_ChIP-Seq_A2780_Human0.86921049
129ESR1_20079471_ChIP-ChIP_T-47D_Human0.86624151
130RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.86305250
131GATA2_19941826_ChIP-Seq_K562_Human0.85214752
132STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.84831756
133* SPI1_23127762_ChIP-Seq_K562_Human0.84775875
134STAT6_21828071_ChIP-Seq_BEAS2B_Human0.83619789
135* NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.83433828
136BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.83246291
137TDRD3_21172665_ChIP-Seq_MCF-7_Human0.83166037
138NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.82977996
139SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.82893104
140IGF1R_20145208_ChIP-Seq_DFB_Human0.82828372
141TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.82405340
142MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.81463022
143CTCF_27219007_Chip-Seq_Bcells_Human0.81143766
144GATA1_19941826_ChIP-Seq_K562_Human0.80940925
145SMAD_19615063_ChIP-ChIP_OVARY_Human0.79424536
146OCT4_19829295_ChIP-Seq_ESCs_Human0.78579318
147NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.78490038
148CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.78401760
149AR_21572438_ChIP-Seq_LNCaP_Human0.78307260
150GATA1_19941827_ChIP-Seq_MEL86_Mouse0.77964072
151TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.77811581
152TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.76617058
153SMRT_27268052_Chip-Seq_Bcells_Human0.76592021
154PKCTHETA_26484144_Chip-Seq_BREAST_Human0.76021388
155DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.76013648
156NR3C1_23031785_ChIP-Seq_PC12_Mouse0.75847712
157NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.75565752
158PRDM14_20953172_ChIP-Seq_ESCs_Human0.75417362

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.67100642
2MP0002009_preneoplasia4.27938648
3MP0004858_abnormal_nervous_system3.63185679
4MP0004270_analgesia3.41746925
5MP0002254_reproductive_system_inflammat3.16127641
6MP0002166_altered_tumor_susceptibility3.08869099
7MP0002822_catalepsy2.87720728
8MP0003635_abnormal_synaptic_transmissio2.78474674
9MP0009046_muscle_twitch2.60341452
10MP0000537_abnormal_urethra_morphology2.38229898
11MP0002909_abnormal_adrenal_gland2.37073995
12MP0003329_amyloid_beta_deposits2.33154708
13MP0002064_seizures2.32582604
14MP0003646_muscle_fatigue2.32388247
15MP0002063_abnormal_learning/memory/cond2.25110747
16MP0008961_abnormal_basal_metabolism2.21012260
17MP0003183_abnormal_peptide_metabolism2.20849227
18MP0009745_abnormal_behavioral_response2.18372819
19MP0004264_abnormal_extraembryonic_tissu2.14045898
20MP0003880_abnormal_central_pattern2.11523404
21MP0002734_abnormal_mechanical_nocicepti2.08677901
22MP0005645_abnormal_hypothalamus_physiol2.04680877
23MP0005360_urolithiasis2.04396538
24MP0001486_abnormal_startle_reflex2.03575240
25MP0002572_abnormal_emotion/affect_behav2.03155909
26MP0001501_abnormal_sleep_pattern1.97873893
27MP0001873_stomach_inflammation1.95661122
28MP0003172_abnormal_lysosome_physiology1.85452425
29MP0002733_abnormal_thermal_nociception1.84775415
30MP0005058_abnormal_lysosome_morphology1.83621929
31MP0002272_abnormal_nervous_system1.79922304
32MP0002006_tumorigenesis1.76697968
33MP0005499_abnormal_olfactory_system1.73144434
34MP0005394_taste/olfaction_phenotype1.73144434
35MP0000604_amyloidosis1.71523027
36MP0000538_abnormal_urinary_bladder1.65059252
37MP0009780_abnormal_chondrocyte_physiolo1.64374493
38MP0002139_abnormal_hepatobiliary_system1.60618993
39MP0005085_abnormal_gallbladder_physiolo1.57416412
40MP0001970_abnormal_pain_threshold1.57029500
41MP0002332_abnormal_exercise_endurance1.56764628
42MP0005365_abnormal_bile_salt1.54855509
43MP0000569_abnormal_digit_pigmentation1.54227899
44MP0002876_abnormal_thyroid_physiology1.53397962
45MP0002735_abnormal_chemical_nociception1.51687171
46MP0003690_abnormal_glial_cell1.49919919
47MP0000955_abnormal_spinal_cord1.49427936
48MP0005646_abnormal_pituitary_gland1.49187924
49MP0003724_increased_susceptibility_to1.48273429
50MP0004381_abnormal_hair_follicle1.47689392
51MP0004130_abnormal_muscle_cell1.47047878
52MP0003045_fibrosis1.46590981
53MP0001968_abnormal_touch/_nociception1.45604032
54MP0005451_abnormal_body_composition1.44666087
55MP0001765_abnormal_ion_homeostasis1.42844019
56MP0008569_lethality_at_weaning1.42822941
57MP0004036_abnormal_muscle_relaxation1.40469309
58MP0003075_altered_response_to1.39000659
59MP0010234_abnormal_vibrissa_follicle1.38968227
60MP0008875_abnormal_xenobiotic_pharmacok1.38547312
61MP0003252_abnormal_bile_duct1.38273173
62MP0001440_abnormal_grooming_behavior1.36316990
63MP0003633_abnormal_nervous_system1.35709354
64MP0004043_abnormal_pH_regulation1.35067919
65MP0000015_abnormal_ear_pigmentation1.34342709
66MP0010329_abnormal_lipoprotein_level1.33659237
67MP0000516_abnormal_urinary_system1.32363068
68MP0005367_renal/urinary_system_phenotyp1.32363068
69MP0002184_abnormal_innervation1.29269192
70MP0001664_abnormal_digestion1.25894335
71MP0005423_abnormal_somatic_nervous1.23975277
72MP0005647_abnormal_sex_gland1.23367310
73MP0004811_abnormal_neuron_physiology1.23212554
74MP0008874_decreased_physiological_sensi1.22606871
75MP0002067_abnormal_sensory_capabilities1.21740288
76MP0000778_abnormal_nervous_system1.18408190
77MP0001835_abnormal_antigen_presentation1.17403721
78MP0002090_abnormal_vision1.17347854
79MP0003705_abnormal_hypodermis_morpholog1.16999768
80MP0000920_abnormal_myelination1.16528521
81MP0003866_abnormal_defecation1.16490659
82MP0000470_abnormal_stomach_morphology1.15484696
83MP0000383_abnormal_hair_follicle1.15099966
84MP0003011_delayed_dark_adaptation1.14789889
85MP0000427_abnormal_hair_cycle1.13772370
86MP0003195_calcinosis1.13591636
87MP0008872_abnormal_physiological_respon1.11506520
88MP0010678_abnormal_skin_adnexa1.11120350
89MP0003787_abnormal_imprinting1.10203376
90MP0004185_abnormal_adipocyte_glucose1.09872360
91MP0001919_abnormal_reproductive_system1.08637492
92MP0002229_neurodegeneration1.08255834
93MP0003122_maternal_imprinting1.07503119
94MP0001984_abnormal_olfaction1.07386614
95MP0002419_abnormal_innate_immunity1.06270011
96MP0005174_abnormal_tail_pigmentation1.06232757
97MP0010386_abnormal_urinary_bladder1.05769067
98MP0006082_CNS_inflammation1.05622667
99MP0003283_abnormal_digestive_organ1.05468693
100MP0005409_darkened_coat_color1.05293427
101MP0003315_abnormal_perineum_morphology1.05234105
102MP0004885_abnormal_endolymph1.04848466
103MP0002557_abnormal_social/conspecific_i1.04698933
104MP0003191_abnormal_cellular_cholesterol1.03539612
105MP0003890_abnormal_embryonic-extraembry1.03050467
106MP0005310_abnormal_salivary_gland1.01698048
107MP0003631_nervous_system_phenotype1.01656593
108MP0002882_abnormal_neuron_morphology1.01636554
109MP0000371_diluted_coat_color1.01525146
110MP0003632_abnormal_nervous_system1.01495359
111MP0003634_abnormal_glial_cell1.01307468
112MP0001790_abnormal_immune_system1.00886184
113MP0005387_immune_system_phenotype1.00886184
114MP0004142_abnormal_muscle_tone1.00284367
115MP0005671_abnormal_response_to1.00214342
116MP0009840_abnormal_foam_cell0.99538243
117MP0005248_abnormal_Harderian_gland0.96950695
118MP0002066_abnormal_motor_capabilities/c0.95032417
119MP0004233_abnormal_muscle_weight0.95018870
120MP0003828_pulmonary_edema0.94530844
121MP0005075_abnormal_melanosome_morpholog0.94209876
122MP0004145_abnormal_muscle_electrophysio0.92656642
123MP0005025_abnormal_response_to0.92639880
124MP0002693_abnormal_pancreas_physiology0.89411471
125MP0002118_abnormal_lipid_homeostasis0.89025407
126MP0005386_behavior/neurological_phenoty0.88948975
127MP0004924_abnormal_behavior0.88948975
128MP0005083_abnormal_biliary_tract0.88149474
129MP0005167_abnormal_blood-brain_barrier0.87754017
130MP0002069_abnormal_eating/drinking_beha0.87538840
131MP0005076_abnormal_cell_differentiation0.86871160
132MP0001800_abnormal_humoral_immune0.86836767
133MP0003436_decreased_susceptibility_to0.86786425
134MP0002653_abnormal_ependyma_morphology0.86704589
135MP0004510_myositis0.84836692
136MP0006292_abnormal_olfactory_placode0.84461214
137MP0002736_abnormal_nociception_after0.84308101
138MP0002138_abnormal_hepatobiliary_system0.83791253
139MP0005535_abnormal_body_temperature0.83744605
140MP0000685_abnormal_immune_system0.83474450
141MP0001756_abnormal_urination0.81869786
142MP0004883_abnormal_blood_vessel0.79629624
143MP0002452_abnormal_antigen_presenting0.79202614
144MP0010155_abnormal_intestine_physiology0.78125121
145MP0003137_abnormal_impulse_conducting0.77976296
146MP0006035_abnormal_mitochondrial_morpho0.77773038
147MP0003879_abnormal_hair_cell0.77227457
148MP0002168_other_aberrant_phenotype0.76937290
149MP0003300_gastrointestinal_ulcer0.76691615
150MP0001849_ear_inflammation0.76609885
151MP0005551_abnormal_eye_electrophysiolog0.75899786
152MP0005448_abnormal_energy_balance0.75859628
153MP0001348_abnormal_lacrimal_gland0.75721098
154MP0002971_abnormal_brown_adipose0.75419681
155MP0002078_abnormal_glucose_homeostasis0.75030819
156MP0000609_abnormal_liver_physiology0.74726710
157MP0004085_abnormal_heartbeat0.74642345
158MP0001663_abnormal_digestive_system0.74536087
159MP0001666_abnormal_nutrient_absorption0.74399076
160MP0002148_abnormal_hypersensitivity_rea0.73436215
161MP0002723_abnormal_immune_serum0.71988607
162MP0004947_skin_inflammation0.71675773
163MP0001764_abnormal_homeostasis0.69569599
164MP0001845_abnormal_inflammatory_respons0.68680808
165MP0004484_altered_response_of0.66934675
166MP0001533_abnormal_skeleton_physiology0.66725280
167MP0002896_abnormal_bone_mineralization0.64977922

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the lower motor neuron (HP:0002366)4.85332834
2Hypochromic microcytic anemia (HP:0004840)4.25373800
3Prostate neoplasm (HP:0100787)3.91762247
4Focal seizures (HP:0007359)3.91541014
5Supranuclear gaze palsy (HP:0000605)3.90314596
6Calf muscle hypertrophy (HP:0008981)3.79089047
7Myokymia (HP:0002411)3.71818978
8Hepatoblastoma (HP:0002884)3.54966605
9Testicular atrophy (HP:0000029)3.54786109
10Muscle hypertrophy of the lower extremities (HP:0008968)3.52221805
11Increased cerebral lipofuscin (HP:0011813)3.46622288
12Bilateral microphthalmos (HP:0007633)3.46331576
13Vacuolated lymphocytes (HP:0001922)3.45341030
14Focal motor seizures (HP:0011153)3.42781298
15Increased neuronal autofluorescent lipopigment (HP:0002074)3.37899832
16Epileptic encephalopathy (HP:0200134)3.34492934
17J-shaped sella turcica (HP:0002680)3.32643515
18Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.31125041
19Action tremor (HP:0002345)3.29585976
20Abnormality of the 1st metacarpal (HP:0010009)3.29386297
21Febrile seizures (HP:0002373)3.27920734
22Neurofibrillary tangles (HP:0002185)3.23220480
23Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)3.22484416
24Short 1st metacarpal (HP:0010034)3.22484416
25Abnormality of polysaccharide metabolism (HP:0011012)3.12243327
26Abnormality of glycosaminoglycan metabolism (HP:0004371)3.12243327
27Abnormality of mucopolysaccharide metabolism (HP:0011020)3.12243327
28Abnormality of the corticospinal tract (HP:0002492)3.07945376
29Hemiparesis (HP:0001269)3.07256015
30Urinary glycosaminoglycan excretion (HP:0003541)3.07034751
31Mucopolysacchariduria (HP:0008155)3.07034751
32Hyperventilation (HP:0002883)3.06600028
33Amyotrophic lateral sclerosis (HP:0007354)3.05269472
34Visual hallucinations (HP:0002367)3.02685020
35Tetraplegia (HP:0002445)3.02234909
36Dysostosis multiplex (HP:0000943)3.00875845
37Dialeptic seizures (HP:0011146)2.99451652
38Abnormality of the axillary hair (HP:0100134)2.95579662
39Abnormality of secondary sexual hair (HP:0009888)2.95579662
40Neoplasm of the heart (HP:0100544)2.93069326
41Status epilepticus (HP:0002133)2.88066261
42Broad face (HP:0000283)2.85272446
43Cerebral inclusion bodies (HP:0100314)2.80408517
44Hyperinsulinemic hypoglycemia (HP:0000825)2.79047080
45Flat acetabular roof (HP:0003180)2.77025931
46Absence seizures (HP:0002121)2.68786337
47Spastic tetraparesis (HP:0001285)2.68539808
48Cheilitis (HP:0100825)2.68396339
49Generalized tonic-clonic seizures (HP:0002069)2.66521259
50Neuronal loss in central nervous system (HP:0002529)2.62209355
51Atonic seizures (HP:0010819)2.61026450
52Skin nodule (HP:0200036)2.58527495
53Difficulty running (HP:0009046)2.58301500
54Intention tremor (HP:0002080)2.58024712
55Testicular neoplasm (HP:0010788)2.56132077
56Dysmetric saccades (HP:0000641)2.52303860
57Hand muscle atrophy (HP:0009130)2.51328698
58Abnormality of the fingertips (HP:0001211)2.51088218
59Short phalanx of the thumb (HP:0009660)2.51082196
60Upper limb amyotrophy (HP:0009129)2.50938030
61Distal upper limb amyotrophy (HP:0007149)2.50938030
62Ankle clonus (HP:0011448)2.50198131
63Clumsiness (HP:0002312)2.49533210
64Dysmetria (HP:0001310)2.47965638
65Progressive cerebellar ataxia (HP:0002073)2.45332005
66Decreased circulating renin level (HP:0003351)2.44012144
67Spastic gait (HP:0002064)2.42161497
68Amblyopia (HP:0000646)2.39369671
69Germ cell neoplasia (HP:0100728)2.37125707
70Deformed sella turcica (HP:0002681)2.36710192
71Postural instability (HP:0002172)2.34471876
72Hemiplegia (HP:0002301)2.32034571
73Recurrent bacterial skin infections (HP:0005406)2.31978340
74Dysdiadochokinesis (HP:0002075)2.31172823
75Abnormality of the sella turcica (HP:0002679)2.29425097
76Lip pit (HP:0100267)2.27211943
77Amelogenesis imperfecta (HP:0000705)2.26109021
78Depression (HP:0000716)2.25952853
79Eczematoid dermatitis (HP:0000976)2.24387623
80Drooling (HP:0002307)2.24310160
81Excessive salivation (HP:0003781)2.24310160
82Impaired smooth pursuit (HP:0007772)2.23487270
83Macroorchidism (HP:0000053)2.23124291
84Abnormality of liposaccharide metabolism (HP:0010968)2.22096003
85Abnormality of glycosphingolipid metabolism (HP:0004343)2.22096003
86Abnormality of glycolipid metabolism (HP:0010969)2.22096003
87Recurrent abscess formation (HP:0002722)2.21209560
88Urinary bladder sphincter dysfunction (HP:0002839)2.19181596
89Neonatal hypoglycemia (HP:0001998)2.14429223
90Hyperkalemia (HP:0002153)2.14326827
91Sparse lateral eyebrow (HP:0005338)2.13056179
92Impaired social interactions (HP:0000735)2.10839496
93Abnormal social behavior (HP:0012433)2.10839496
94Open mouth (HP:0000194)2.09422261
95Abnormality of the Achilles tendon (HP:0005109)2.07595180
96Lower limb muscle weakness (HP:0007340)2.07353028
97Resting tremor (HP:0002322)2.07106785
98Generalized hypotonia (HP:0001290)2.05666994
99Upper motor neuron abnormality (HP:0002127)2.04452064
100Achilles tendon contracture (HP:0001771)2.04158955
101Onion bulb formation (HP:0003383)2.03914047
102Abnormality of macrophages (HP:0004311)2.03568984
103Horizontal nystagmus (HP:0000666)2.02739308
104Bulbar palsy (HP:0001283)2.00962892
105Disproportionate short-trunk short stature (HP:0003521)1.99195464
106Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.98949032
107Abnormality of the renal cortex (HP:0011035)1.98482444
108Generalized myoclonic seizures (HP:0002123)1.98448136
109Cone-rod dystrophy (HP:0000548)1.98165452
110Abnormality of the distal phalanx of the thumb (HP:0009617)1.97656551
111Mutism (HP:0002300)1.96883959
112Genetic anticipation (HP:0003743)1.95983573
113Amyloidosis (HP:0011034)1.95539615
114Azoospermia (HP:0000027)1.95401224
115Autoimmune thrombocytopenia (HP:0001973)1.93688783
116Protruding tongue (HP:0010808)1.93662110
117Hypoplasia of the odontoid process (HP:0003311)1.93306505
118Astrocytoma (HP:0009592)1.92064604
119Abnormality of the astrocytes (HP:0100707)1.92064604
120Obstructive sleep apnea (HP:0002870)1.91481854
121Intrahepatic cholestasis (HP:0001406)1.89408738
122Thin bony cortex (HP:0002753)1.89345128
123Truncal obesity (HP:0001956)1.89190713
124Abnormality of the prostate (HP:0008775)1.88460684
125Asymmetric septal hypertrophy (HP:0001670)1.87072524
126Gingivitis (HP:0000230)1.86713629
127Rapidly progressive (HP:0003678)1.85879976
128Apathy (HP:0000741)1.84577594
129Recurrent fungal infections (HP:0002841)1.83186442
130EMG: neuropathic changes (HP:0003445)1.83017832
131Epidermoid cyst (HP:0200040)1.83010117
132Generalized hypopigmentation of hair (HP:0011358)1.82674673
133Xanthomatosis (HP:0000991)1.82613826
134Sensory axonal neuropathy (HP:0003390)1.82141628
135Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.81887558
136Torticollis (HP:0000473)1.81790796
137Pseudobulbar signs (HP:0002200)1.79898816
138Ependymoma (HP:0002888)1.79756358
139Syncope (HP:0001279)1.78679865
140Abnormality of the musculature of the hand (HP:0001421)1.78634541
141Abnormality of ocular smooth pursuit (HP:0000617)1.78577808
142Large earlobe (HP:0009748)1.78137833
143Loss of speech (HP:0002371)1.77853787
144Clonus (HP:0002169)1.77465346
145Gaze-evoked nystagmus (HP:0000640)1.77324204
146Deep venous thrombosis (HP:0002625)1.77051602
147Increased CSF protein (HP:0002922)1.76626887
148Tented upper lip vermilion (HP:0010804)1.76294661
149Abnormality of the periventricular white matter (HP:0002518)1.75951154
150Abnormality of the salivary glands (HP:0010286)1.75723330
151Stomatitis (HP:0010280)1.75624761
152Urinary urgency (HP:0000012)1.74562938
153Protuberant abdomen (HP:0001538)1.73930461
154Diplopia (HP:0000651)1.73472451
155Abnormality of binocular vision (HP:0011514)1.73472451
156Curly hair (HP:0002212)1.73310429
157Scanning speech (HP:0002168)1.72981736
158Widely spaced teeth (HP:0000687)1.72512331
159Impaired vibratory sensation (HP:0002495)1.71852954
160Bradykinesia (HP:0002067)1.71482468
161Septate vagina (HP:0001153)1.68851257
162Malnutrition (HP:0004395)1.68752722
163Recurrent cutaneous fungal infections (HP:0011370)1.66464594
164Chronic mucocutaneous candidiasis (HP:0002728)1.66464594
165Gout (HP:0001997)1.65882429
166Abnormality of the odontoid process (HP:0003310)1.65704995
167Truncal ataxia (HP:0002078)1.65379330
168Poor eye contact (HP:0000817)1.64938844
169Cardiomegaly (HP:0001640)1.63687212
170Morphological abnormality of the pyramidal tract (HP:0002062)1.63327304
171Absent speech (HP:0001344)1.63195318
172Bundle branch block (HP:0011710)1.61894340
173Prolonged QT interval (HP:0001657)1.61438574
174Hamartoma of the eye (HP:0010568)1.61280726
175Abnormality of male internal genitalia (HP:0000022)1.60368686
176Heterotopia (HP:0002282)1.59318017
177Abdominal distention (HP:0003270)1.58605896
178Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.58276981
179Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.58203762
180Macroglossia (HP:0000158)1.56381757
181Agitation (HP:0000713)1.55659633
182Recurrent skin infections (HP:0001581)1.54949271
183Exercise-induced myalgia (HP:0003738)1.54177063
184Tibial bowing (HP:0002982)1.52380469

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.82597956
2MAP3K93.42556126
3TRIB33.18894194
4GRK53.18464532
5ERN12.85607238
6NTRK32.70335567
7EPHA42.52697043
8FRK2.48923938
9NTRK12.35771350
10GRK62.19168010
11EEF2K2.03796788
12TYRO32.00280208
13PAK61.93394755
14MAP2K41.87848604
15WNK11.83648503
16MAPKAPK31.80246215
17DAPK21.74259759
18PKN21.71133246
19FER1.69814764
20KSR21.66406490
21MARK21.62864151
22MARK11.62178041
23MAP3K41.60104206
24RIPK11.57786764
25MAP3K131.51618933
26NTRK21.42111571
27RIPK41.41200953
28ACVR1B1.40076825
29MAP3K71.38747895
30SIK21.36888949
31BLK1.33092214
32MINK11.25344199
33CSF1R1.24168112
34TRPM71.23682186
35MAPK71.22382008
36ADRBK21.18354876
37GRK71.16662039
38TAOK31.12239457
39GRK11.11627373
40MAP3K21.11076086
41TGFBR21.11056538
42RPS6KA21.09893223
43PRKD31.09663349
44CAMK41.08324162
45TAOK11.07892433
46ICK1.05440244
47CAMK1G1.04288428
48MAP2K31.03021971
49PIK3CA1.02882333
50CAMKK11.01583836
51CDK51.01076762
52STK381.00431659
53CAMKK20.98300147
54PHKG10.98299567
55PHKG20.98299567
56MAP3K30.98146116
57FGFR30.97958862
58PRKAA20.97950352
59SIK10.97804743
60MOS0.96919849
61EPHB10.94951546
62PRKCH0.92448729
63PRKCI0.92120326
64MAPK130.91195347
65IRAK20.89428717
66OBSCN0.89415633
67PRKG20.86934416
68PRPF4B0.86913021
69PTK20.86370446
70MATK0.84731904
71HIPK20.84263802
72YES10.82878073
73MAP4K10.79954672
74CAMK1D0.77678798
75CHUK0.77220256
76FGFR40.77160272
77ALK0.76819230
78TYK20.76725441
79TTN0.76575716
80PAK30.74730247
81LMTK20.73848994
82SGK30.72633137
83RPS6KA60.71355484
84RET0.69820767
85INSRR0.69618750
86WNK40.66098996
87PINK10.65386458
88MAPK120.65225452
89JAK10.64753646
90MAP2K60.64146174
91IRAK10.64077517
92RPS6KL10.63875003
93RPS6KC10.63875003
94AKT30.62431117
95SGK4940.61533758
96SGK2230.61533758
97PIK3CG0.61135534
98PDK10.60924201
99TXK0.60638161
100PRKCG0.60305925
101STK110.59880855
102CASK0.58397956
103IKBKE0.58266015
104MAP3K10.57828940
105MAP2K70.57396700
106STK390.57237140
107TNK20.56365299
108DYRK1A0.56119392
109KSR10.54973113
110ADRBK10.54151402
111CAMK10.54115519
112ZAP700.53713244
113PDPK10.53144954
114MAP3K140.52677108
115CSK0.51136131
116ERBB20.50826626
117FYN0.50692310
118JAK20.50637431
119PRKAA10.50459630
120RPS6KA30.50124070
121SGK10.48563112
122BMX0.48461920
123UHMK10.48025790
124DMPK0.47916134
125NEK60.47379325
126MAP3K110.46023124
127HCK0.45030519
128SGK20.44498417
129SYK0.44436793
130PKN10.44302786
131MAPK100.44176185
132PRKD20.44013492
133IRAK40.42876632
134EPHA20.42467720
135FES0.42223346
136IKBKB0.42135453
137PRKCZ0.42129054
138CDC42BPA0.42012353
139PRKACG0.41435104
140KIT0.41011417
141PTK2B0.40391475
142STK100.40277651
143CDK150.39805969
144ITK0.38725150
145PRKCQ0.38360059
146MTOR0.38061434
147PRKD10.37736881

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.57067830
2GABAergic synapse_Homo sapiens_hsa047271.90319985
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.86230766
4Nicotine addiction_Homo sapiens_hsa050331.85424750
5Synaptic vesicle cycle_Homo sapiens_hsa047211.81046290
6Glutamatergic synapse_Homo sapiens_hsa047241.80079820
7Other glycan degradation_Homo sapiens_hsa005111.78578488
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.75149174
9Glycosaminoglycan degradation_Homo sapiens_hsa005311.73039272
10Salivary secretion_Homo sapiens_hsa049701.58740424
11Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.55383328
12Circadian entrainment_Homo sapiens_hsa047131.53808005
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.49273215
14Morphine addiction_Homo sapiens_hsa050321.46909052
15Olfactory transduction_Homo sapiens_hsa047401.46300198
16Long-term potentiation_Homo sapiens_hsa047201.45181506
17Insulin secretion_Homo sapiens_hsa049111.42401079
18Type II diabetes mellitus_Homo sapiens_hsa049301.39721892
19Bile secretion_Homo sapiens_hsa049761.39454270
20Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.37625265
21Arginine biosynthesis_Homo sapiens_hsa002201.28195669
22Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.27270955
23Vitamin B6 metabolism_Homo sapiens_hsa007501.25099742
24Phosphatidylinositol signaling system_Homo sapiens_hsa040701.24430404
25Taste transduction_Homo sapiens_hsa047421.21885668
26Lysine degradation_Homo sapiens_hsa003101.17832455
27Primary bile acid biosynthesis_Homo sapiens_hsa001201.17789037
28Osteoclast differentiation_Homo sapiens_hsa043801.16707348
29Dorso-ventral axis formation_Homo sapiens_hsa043201.16309819
30Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.15920151
31Gastric acid secretion_Homo sapiens_hsa049711.15375802
32Renin secretion_Homo sapiens_hsa049241.14419781
33Renin-angiotensin system_Homo sapiens_hsa046141.14250596
34Cholinergic synapse_Homo sapiens_hsa047251.13287789
35Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.12812273
36Acute myeloid leukemia_Homo sapiens_hsa052211.12807184
37Fructose and mannose metabolism_Homo sapiens_hsa000511.12738352
38Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.10684619
39Aldosterone synthesis and secretion_Homo sapiens_hsa049251.09778279
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.08852481
41Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.07880178
42GnRH signaling pathway_Homo sapiens_hsa049121.07296841
43Platelet activation_Homo sapiens_hsa046111.06589782
44Dopaminergic synapse_Homo sapiens_hsa047281.06517309
45Long-term depression_Homo sapiens_hsa047301.03872576
46Phospholipase D signaling pathway_Homo sapiens_hsa040721.02753569
47B cell receptor signaling pathway_Homo sapiens_hsa046621.02134744
48Oxytocin signaling pathway_Homo sapiens_hsa049211.01479777
49Serotonergic synapse_Homo sapiens_hsa047261.00109651
50Calcium signaling pathway_Homo sapiens_hsa040200.99105808
51Linoleic acid metabolism_Homo sapiens_hsa005910.97960485
52Tuberculosis_Homo sapiens_hsa051520.97260209
53Sphingolipid metabolism_Homo sapiens_hsa006000.96372925
54ABC transporters_Homo sapiens_hsa020100.94803482
55cAMP signaling pathway_Homo sapiens_hsa040240.94246093
56Amphetamine addiction_Homo sapiens_hsa050310.92687336
57Carbohydrate digestion and absorption_Homo sapiens_hsa049730.90621808
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.89323078
59Staphylococcus aureus infection_Homo sapiens_hsa051500.89028813
60Choline metabolism in cancer_Homo sapiens_hsa052310.88257877
61mTOR signaling pathway_Homo sapiens_hsa041500.87512861
62Glucagon signaling pathway_Homo sapiens_hsa049220.85358750
63Notch signaling pathway_Homo sapiens_hsa043300.84595414
64AMPK signaling pathway_Homo sapiens_hsa041520.84554093
65T cell receptor signaling pathway_Homo sapiens_hsa046600.84028926
66Inositol phosphate metabolism_Homo sapiens_hsa005620.83667669
67Ether lipid metabolism_Homo sapiens_hsa005650.82528103
68Cocaine addiction_Homo sapiens_hsa050300.81476126
69Vascular smooth muscle contraction_Homo sapiens_hsa042700.79291902
70Toll-like receptor signaling pathway_Homo sapiens_hsa046200.79275103
71Endometrial cancer_Homo sapiens_hsa052130.77088591
72Insulin signaling pathway_Homo sapiens_hsa049100.76421030
73Prostate cancer_Homo sapiens_hsa052150.75514427
74Renal cell carcinoma_Homo sapiens_hsa052110.75351590
75Glycerophospholipid metabolism_Homo sapiens_hsa005640.74858946
76PPAR signaling pathway_Homo sapiens_hsa033200.74746702
77Prolactin signaling pathway_Homo sapiens_hsa049170.74393902
78ErbB signaling pathway_Homo sapiens_hsa040120.74311274
79Tryptophan metabolism_Homo sapiens_hsa003800.73989276
80Leishmaniasis_Homo sapiens_hsa051400.73567436
81Axon guidance_Homo sapiens_hsa043600.72963565
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72929876
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71765169
84Histidine metabolism_Homo sapiens_hsa003400.71352113
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68986627
86TNF signaling pathway_Homo sapiens_hsa046680.68662211
87Complement and coagulation cascades_Homo sapiens_hsa046100.68449541
88Gap junction_Homo sapiens_hsa045400.67421664
89Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.66585419
90Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66073858
91Estrogen signaling pathway_Homo sapiens_hsa049150.65613168
92Glycerolipid metabolism_Homo sapiens_hsa005610.65474446
93VEGF signaling pathway_Homo sapiens_hsa043700.65037050
94Leukocyte transendothelial migration_Homo sapiens_hsa046700.64966621
95Hepatitis C_Homo sapiens_hsa051600.64541136
96cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64306273
97Vitamin digestion and absorption_Homo sapiens_hsa049770.64078573
98Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.62624780
99Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.61658851
100Galactose metabolism_Homo sapiens_hsa000520.60668805
101Glioma_Homo sapiens_hsa052140.60635909
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.60324301
103FoxO signaling pathway_Homo sapiens_hsa040680.59731896
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59632937
105Insulin resistance_Homo sapiens_hsa049310.58753684
106African trypanosomiasis_Homo sapiens_hsa051430.57173525
107Pancreatic secretion_Homo sapiens_hsa049720.55903210
108Sulfur metabolism_Homo sapiens_hsa009200.55829017
109Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.55606967
110Rap1 signaling pathway_Homo sapiens_hsa040150.55559343
111Fat digestion and absorption_Homo sapiens_hsa049750.55390200
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.55169737
113Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.54874745
114Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54142892
115Mineral absorption_Homo sapiens_hsa049780.53628562
116Neurotrophin signaling pathway_Homo sapiens_hsa047220.53303032
117Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.53226712
118MAPK signaling pathway_Homo sapiens_hsa040100.53121059
119Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52382184
120Ovarian steroidogenesis_Homo sapiens_hsa049130.52363201
121Fatty acid biosynthesis_Homo sapiens_hsa000610.50934949
122Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49607877
123Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49519979
124Collecting duct acid secretion_Homo sapiens_hsa049660.49174164
125Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.47643462
126Butanoate metabolism_Homo sapiens_hsa006500.47555179
127Caffeine metabolism_Homo sapiens_hsa002320.46777840
128Endocytosis_Homo sapiens_hsa041440.46705414
129Dilated cardiomyopathy_Homo sapiens_hsa054140.46032428
130Non-small cell lung cancer_Homo sapiens_hsa052230.42983703
131Ras signaling pathway_Homo sapiens_hsa040140.42555436
132Thyroid hormone synthesis_Homo sapiens_hsa049180.41578163
133Lysosome_Homo sapiens_hsa041420.40732533
134alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.39848126
135Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39834247
136Starch and sucrose metabolism_Homo sapiens_hsa005000.39829472
137Chemokine signaling pathway_Homo sapiens_hsa040620.39336718
138Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.39335995

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