DOT1L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a histone methyltransferase that methylates lysine-79 of histone H3. It is inactive against free core histones, but shows significant histone methyltransferase activity against nucleosomes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of vitamin D biosynthetic process (GO:0060556)4.80810817
2negative regulation of erythrocyte differentiation (GO:0045647)4.54416778
3activation of MAPKKK activity (GO:0000185)4.33449875
4response to peptidoglycan (GO:0032494)4.24659719
5pre-miRNA processing (GO:0031054)4.20645200
6histone H3-K4 trimethylation (GO:0080182)4.13371099
7response to muramyl dipeptide (GO:0032495)4.09068412
8mannose metabolic process (GO:0006013)3.97447298
9regulation of NFAT protein import into nucleus (GO:0051532)3.94327071
10NIK/NF-kappaB signaling (GO:0038061)3.87969471
11nuclear pore complex assembly (GO:0051292)3.77102233
12lipopolysaccharide-mediated signaling pathway (GO:0031663)3.76630993
13regulation of vitamin metabolic process (GO:0030656)3.69937603
14positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.64085703
15positive regulation of heat generation (GO:0031652)3.61800663
16histone H3-K4 methylation (GO:0051568)3.49602808
17cytoplasmic mRNA processing body assembly (GO:0033962)3.43684926
18intracellular estrogen receptor signaling pathway (GO:0030520)3.43334541
19negative regulation of interleukin-12 production (GO:0032695)3.41803641
20CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.41021192
21germinal center formation (GO:0002467)3.40438303
22NLS-bearing protein import into nucleus (GO:0006607)3.38687098
23positive regulation of histone deacetylation (GO:0031065)3.31820525
24positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.29156738
25positive regulation of chemokine biosynthetic process (GO:0045080)3.27018948
26regulation of interleukin-12 biosynthetic process (GO:0045075)3.25837416
27regulation of podosome assembly (GO:0071801)3.23825022
28regulation of type I interferon-mediated signaling pathway (GO:0060338)3.22837534
29mRNA stabilization (GO:0048255)3.20276051
30RNA stabilization (GO:0043489)3.20276051
31regulation of cholesterol storage (GO:0010885)3.18708237
32nuclear pore organization (GO:0006999)3.18052061
33heterochromatin organization (GO:0070828)3.18019010
34low-density lipoprotein particle clearance (GO:0034383)3.17952107
35regulation of gamma-delta T cell differentiation (GO:0045586)3.17665116
36peptidyl-lysine dimethylation (GO:0018027)3.15857054
37myeloid dendritic cell differentiation (GO:0043011)3.11546462
38negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.09965995
39positive thymic T cell selection (GO:0045059)3.09937117
40negative regulation of histone methylation (GO:0031061)3.09810494
41regulation of fever generation (GO:0031620)3.09324332
42positive regulation of gene expression, epigenetic (GO:0045815)3.06378114
43protein localization to endosome (GO:0036010)3.03275964
44regulation of gamma-delta T cell activation (GO:0046643)3.00970171
45positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.00937632
46mitotic sister chromatid cohesion (GO:0007064)2.98547003
47chromatin silencing (GO:0006342)2.97475229
48regulation of monocyte differentiation (GO:0045655)2.95814599
49regulation of interleukin-2 biosynthetic process (GO:0045076)2.94813738
50regulation of chemokine biosynthetic process (GO:0045073)2.94542132
51T-helper 1 type immune response (GO:0042088)2.94120521
52regulation of cytokine secretion involved in immune response (GO:0002739)2.92960246
53macrophage activation involved in immune response (GO:0002281)2.92384644
54peptidyl-lysine trimethylation (GO:0018023)2.89829650
55positive regulation of RNA splicing (GO:0033120)2.88374275
56gene silencing (GO:0016458)2.87010016
57modulation by symbiont of host cellular process (GO:0044068)2.86964960
58positive regulation of gamma-delta T cell activation (GO:0046645)2.85761975
59regulation of RNA export from nucleus (GO:0046831)2.82461904
60modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.81781571
61positive regulation by organism of defense response of other organism involved in symbiotic interact2.81781571
62modulation by symbiont of host immune response (GO:0052553)2.81781571
63positive regulation by symbiont of host defense response (GO:0052509)2.81781571
64modulation by symbiont of host defense response (GO:0052031)2.81781571
65modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.81781571
66regulation of chromatin binding (GO:0035561)2.81561956
67regulation of early endosome to late endosome transport (GO:2000641)2.81439372
68histone H3-K36 demethylation (GO:0070544)2.78856666
69peptidyl-lysine methylation (GO:0018022)2.77981424
70* histone lysine methylation (GO:0034968)2.77960479
71negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.76377121
72negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.75565784
73cytoskeletal anchoring at plasma membrane (GO:0007016)2.75278417
74cellular response to virus (GO:0098586)2.75103537
75negative regulation of cytokine production involved in immune response (GO:0002719)2.74159481
76regulation of integrin activation (GO:0033623)2.73773953
77regulation of nucleobase-containing compound transport (GO:0032239)2.70525978
78T cell lineage commitment (GO:0002360)2.69978267
79protein localization to chromosome, centromeric region (GO:0071459)2.69925225
80regulation of membrane protein ectodomain proteolysis (GO:0051043)2.68825172
81gene silencing by RNA (GO:0031047)2.68542438
82regulation of chronic inflammatory response (GO:0002676)2.66437948
83regulation of interferon-alpha production (GO:0032647)2.66098104
84response to laminar fluid shear stress (GO:0034616)2.65662426
85pore complex assembly (GO:0046931)2.65506319
86glycosphingolipid catabolic process (GO:0046479)2.65139127
87regulation of p38MAPK cascade (GO:1900744)2.65072970
88epithelial cell differentiation involved in prostate gland development (GO:0060742)2.64583987
89histone H4-K16 acetylation (GO:0043984)2.64472878
90positive regulation of transcription factor import into nucleus (GO:0042993)2.63738826
91negative regulation of toll-like receptor signaling pathway (GO:0034122)2.62823597
92negative regulation of myeloid cell apoptotic process (GO:0033033)2.62375629
93regulation of T-helper 1 cell differentiation (GO:0045625)2.61129289
94regulation of cholesterol homeostasis (GO:2000188)2.58616029
95focal adhesion assembly (GO:0048041)2.57624322
96cell-substrate adherens junction assembly (GO:0007045)2.57624322
97regulation of histone H3-K27 methylation (GO:0061085)2.57604783
98modulation by virus of host process (GO:0019054)2.57451230
99response to protozoan (GO:0001562)2.56944244
100negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.56284799
101stress granule assembly (GO:0034063)2.55573933
102negative regulation of gene expression, epigenetic (GO:0045814)2.55359200
103apoptotic process involved in morphogenesis (GO:0060561)2.55296298
104corticosteroid receptor signaling pathway (GO:0031958)2.54299293
105positive T cell selection (GO:0043368)2.53475015
106adherens junction assembly (GO:0034333)2.53230607
107glucocorticoid receptor signaling pathway (GO:0042921)2.52365567
108myeloid dendritic cell activation (GO:0001773)2.50903050
109cardiac myofibril assembly (GO:0055003)2.50757346
110histone H3-K9 methylation (GO:0051567)2.49980243
111negative regulation of translation, ncRNA-mediated (GO:0040033)2.49753268
112regulation of translation, ncRNA-mediated (GO:0045974)2.49753268
113negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.49753268
114regulation of translational fidelity (GO:0006450)2.49395025
115regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.49125805
116histone H4 acetylation (GO:0043967)2.48214290
117protein localization to kinetochore (GO:0034501)2.47192985
118regulation of glucose import in response to insulin stimulus (GO:2001273)2.46289581
119response to type I interferon (GO:0034340)2.46163288
120Peyers patch development (GO:0048541)2.45630391
121mucosal-associated lymphoid tissue development (GO:0048537)2.45630391
122cell-cell junction maintenance (GO:0045217)2.45075620
123semaphorin-plexin signaling pathway (GO:0071526)2.44830611
124negative regulation of potassium ion transmembrane transport (GO:1901380)2.44769837
125* histone methylation (GO:0016571)2.44581723
126histone H4-K8 acetylation (GO:0043982)2.44068749
127histone H4-K5 acetylation (GO:0043981)2.44068749
128regulation of ARF GTPase activity (GO:0032312)2.42161114
129histone H4-K12 acetylation (GO:0043983)2.41715484
130type I interferon signaling pathway (GO:0060337)2.41606040
131cellular response to type I interferon (GO:0071357)2.41606040
132thymic T cell selection (GO:0045061)2.40467403
133adhesion of symbiont to host (GO:0044406)2.40140390
134activation of JUN kinase activity (GO:0007257)2.40024019
135regulation of mRNA stability (GO:0043488)2.40006344
1363-UTR-mediated mRNA stabilization (GO:0070935)2.39676757
137oligosaccharide catabolic process (GO:0009313)2.39356652
138negative regulation of mRNA metabolic process (GO:1903312)2.38785774
139negative regulation of mRNA processing (GO:0050686)2.38699481
140establishment of nucleus localization (GO:0040023)2.38623082
141positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.37021100
142histone H3-K9 modification (GO:0061647)2.36950330
143sodium ion export (GO:0071436)2.36700853
144planar cell polarity pathway involved in neural tube closure (GO:0090179)2.36161690
145mitotic nuclear envelope disassembly (GO:0007077)2.35614401
146histone lysine demethylation (GO:0070076)2.35316187
147nucleosome disassembly (GO:0006337)2.34944348
148protein-DNA complex disassembly (GO:0032986)2.34944348
149dosage compensation (GO:0007549)2.34922210
150endothelial cell chemotaxis (GO:0035767)2.34537288
151regulation of interferon-gamma biosynthetic process (GO:0045072)2.34163970
152positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.33679650
153regulation of histone H3-K9 methylation (GO:0051570)2.33575594
154embryonic process involved in female pregnancy (GO:0060136)2.33270248
155regulation of translational termination (GO:0006449)2.33218229
156mitotic chromosome condensation (GO:0007076)2.33185336
157pinocytosis (GO:0006907)2.32712351
158immunoglobulin mediated immune response (GO:0016064)2.32486143
159cellular response to lipopolysaccharide (GO:0071222)2.31688573
160regulation of heat generation (GO:0031650)2.31652372
161positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.31554736
162positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.31466662
163nuclear envelope disassembly (GO:0051081)2.30011691
164membrane disassembly (GO:0030397)2.30011691
165glycolipid catabolic process (GO:0019377)2.29733493
166regulation of interferon-beta biosynthetic process (GO:0045357)2.29480296
167regulation of RNA stability (GO:0043487)2.29479608
168monocyte chemotaxis (GO:0002548)2.27652676
169positive regulation of interferon-alpha production (GO:0032727)2.27624861
170negative regulation of organelle assembly (GO:1902116)2.27282149
171histone demethylation (GO:0016577)2.27185134
172plasma membrane repair (GO:0001778)2.26903178
173synaptonemal complex assembly (GO:0007130)2.26584231
174positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.25996067
175regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.25996067
176peptidyl-threonine phosphorylation (GO:0018107)2.25452649
177cerebellar Purkinje cell differentiation (GO:0021702)2.25098977
178mRNA splice site selection (GO:0006376)2.24341225
179regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.24240735
180monoubiquitinated protein deubiquitination (GO:0035520)2.23781227
181positive regulation of mRNA catabolic process (GO:0061014)2.22546798
182spliceosomal tri-snRNP complex assembly (GO:0000244)2.22384499

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_22102868_ChIP-Seq_BL_Human3.84755016
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.71641846
3E2F7_22180533_ChIP-Seq_HELA_Human3.68992985
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.58970307
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.28909930
6STAT6_21828071_ChIP-Seq_BEAS2B_Human3.23041627
7KDM2B_26808549_Chip-Seq_DND41_Human3.03151983
8* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.92967573
9TCF7_22412390_ChIP-Seq_EML_Mouse2.87170255
10* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.81073365
11KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.72554552
12KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.66263154
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.65771431
14VDR_21846776_ChIP-Seq_THP-1_Human2.57024086
15NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.56581906
16* KDM2B_26808549_Chip-Seq_K562_Human2.20202068
17* KDM2B_26808549_Chip-Seq_JURKAT_Human2.10683029
18SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.07879759
19ZFP281_27345836_Chip-Seq_ESCs_Mouse2.05846000
20TP63_17297297_ChIP-ChIP_HaCaT_Human1.82275126
21RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.82192076
22* ELK3_25401928_ChIP-Seq_HUVEC_Human1.78943500
23DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.75425674
24* UTX_26944678_Chip-Seq_JUKART_Human1.74863735
25ZFP281_18757296_ChIP-ChIP_E14_Mouse1.74819544
26FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.66087952
27MAF_26560356_Chip-Seq_TH1_Human1.65779333
28* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.64154230
29VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.62458425
30IRF8_22096565_ChIP-ChIP_GC-B_Human1.61176708
31TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.60511059
32CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.58137287
33LXR_22292898_ChIP-Seq_THP-1_Human1.56660947
34VDR_24763502_ChIP-Seq_THP-1_Human1.55910252
35RARG_19884340_ChIP-ChIP_MEFs_Mouse1.55559929
36* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.55547947
37MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.53114378
38GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.50804691
39* RARB_27405468_Chip-Seq_BRAIN_Mouse1.50112548
40TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.47869744
41ERG_21242973_ChIP-ChIP_JURKAT_Human1.47614057
42* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.47359642
43WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.46906728
44* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.46729153
45SCL_19346495_ChIP-Seq_HPC-7_Human1.45899686
46* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.44032374
47FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.42312794
48RACK7_27058665_Chip-Seq_MCF-7_Human1.42251455
49KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.41850025
50BP1_19119308_ChIP-ChIP_Hs578T_Human1.41646969
51RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40484478
52DROSHA_22980978_ChIP-Seq_HELA_Human1.39626341
53TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.39547250
54ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.38164119
55SA1_27219007_Chip-Seq_ERYTHROID_Human1.36982720
56* SPI1_23127762_ChIP-Seq_K562_Human1.36222332
57E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.36079323
58PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.35530895
59RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.35234353
60* NCOR1_26117541_ChIP-Seq_K562_Human1.34552913
61* CREB1_26743006_Chip-Seq_LNCaP_Human1.32278742
62* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.31857746
63THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.31724320
64EZH2_22144423_ChIP-Seq_EOC_Human1.31063990
65KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.31045700
66ELF1_20517297_ChIP-Seq_JURKAT_Human1.29442151
67* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27345083
68MAF_26560356_Chip-Seq_TH2_Human1.27076533
69* MYB_26560356_Chip-Seq_TH1_Human1.26570521
70TET1_21451524_ChIP-Seq_MESCs_Mouse1.25214070
71ESR2_21235772_ChIP-Seq_MCF-7_Human1.25103543
72RUNX1_27514584_Chip-Seq_MCF-7_Human1.23292159
73GATA1_19941827_ChIP-Seq_MEL_Mouse1.22229553
74SRY_22984422_ChIP-ChIP_TESTIS_Rat1.22043739
75MYB_21317192_ChIP-Seq_ERMYB_Mouse1.21825317
76KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.21574941
77PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20485188
78CIITA_25753668_ChIP-Seq_RAJI_Human1.20440640
79ZNF263_19887448_ChIP-Seq_K562_Human1.20391047
80STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.20374609
81IRF8_21731497_ChIP-ChIP_J774_Mouse1.20253431
82* BCOR_27268052_Chip-Seq_Bcells_Human1.19964189
83FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.19814840
84SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.19560843
85HIF1A_21447827_ChIP-Seq_MCF-7_Human1.19083730
86DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.19036004
87TP53_22127205_ChIP-Seq_IMR90_Human1.18949046
88NFIB_24661679_ChIP-Seq_LUNG_Mouse1.17342356
89* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.17117162
90GATA1_19941826_ChIP-Seq_K562_Human1.15866466
91IRF8_27001747_Chip-Seq_BMDM_Mouse1.15767767
92SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15678794
93CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.15080347
94GATA1_22383799_ChIP-Seq_G1ME_Mouse1.13233541
95* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.12410799
96RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.11927224
97TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.11396943
98RUNX_20019798_ChIP-Seq_JUKART_Human1.11164995
99ATF3_27146783_Chip-Seq_COLON_Human1.10786118
100CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.10684651
101SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10412233
102STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.10257718
103PKCTHETA_26484144_Chip-Seq_BREAST_Human1.09712392
104MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.09617228
105* BCL6_27268052_Chip-Seq_Bcells_Human1.09277745
106MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.08304681
107CTCF_27219007_Chip-Seq_ERYTHROID_Human1.06481064
108DNAJC2_21179169_ChIP-ChIP_NT2_Human1.05977782
109* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05669243
110MYB_26560356_Chip-Seq_TH2_Human1.05566180
111CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05488845
112STAT3_1855785_ChIP-Seq_MESCs_Mouse1.04840423
113* TBX20_22328084_ChIP-Seq_HEART_Mouse1.04747574
114* TBX20_22080862_ChIP-Seq_HEART_Mouse1.04747574
115NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.04626597
116ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.03144872
117* P68_20966046_ChIP-Seq_HELA_Human1.02558466
118* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.02312856
119PU.1_20513432_ChIP-Seq_Bcells_Mouse1.02299066
120* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.01659504
121DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01587455
122UBF1/2_26484160_Chip-Seq_HMECs_Human1.01583122
123UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.00077368
124* ISL1_27105846_Chip-Seq_CPCs_Mouse0.99555580
125RUNX1_22412390_ChIP-Seq_EML_Mouse0.99194667
126MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.98981899
127CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.98947967
128EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.98793766
129SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.98598436
130TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.98120299
131KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.97345046
132OCT4_19829295_ChIP-Seq_ESCs_Human0.95956418
133SMC4_20622854_ChIP-Seq_HELA_Human0.94760733
134ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.94386793
135E2F1_21310950_ChIP-Seq_MCF-7_Human0.93863239
136ELK4_26923725_Chip-Seq_MESODERM_Mouse0.92635736
137TP63_19390658_ChIP-ChIP_HaCaT_Human0.91395792
138RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.90789301
139NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.89541386
140FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.89312844

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology3.49699694
2MP0005451_abnormal_body_composition3.38532174
3MP0003436_decreased_susceptibility_to3.25427497
4MP0009840_abnormal_foam_cell2.93290026
5MP0005076_abnormal_cell_differentiation2.78809881
6MP0008961_abnormal_basal_metabolism2.73247766
7MP0003172_abnormal_lysosome_physiology2.69968211
8MP0004510_myositis2.68633031
9MP0009278_abnormal_bone_marrow2.67194734
10MP0000569_abnormal_digit_pigmentation2.53764315
11MP0008877_abnormal_DNA_methylation2.24402885
12MP0004947_skin_inflammation2.21501676
13MP0003303_peritoneal_inflammation2.18894994
14MP0003453_abnormal_keratinocyte_physiol2.18377236
15MP0000751_myopathy2.18322034
16MP0005000_abnormal_immune_tolerance2.11027134
17MP0003705_abnormal_hypodermis_morpholog2.04836165
18MP0003300_gastrointestinal_ulcer2.02953319
19MP0002148_abnormal_hypersensitivity_rea2.00571326
20MP0002653_abnormal_ependyma_morphology1.94931767
21MP0002139_abnormal_hepatobiliary_system1.93055904
22MP0005671_abnormal_response_to1.90968046
23* MP0003111_abnormal_nucleus_morphology1.89979161
24MP0005410_abnormal_fertilization1.86373548
25MP0001835_abnormal_antigen_presentation1.85078257
26MP0005025_abnormal_response_to1.83510881
27MP0002419_abnormal_innate_immunity1.82249678
28MP0009333_abnormal_splenocyte_physiolog1.81980771
29MP0009785_altered_susceptibility_to1.75244098
30MP0008057_abnormal_DNA_replication1.71521758
31MP0001800_abnormal_humoral_immune1.71300832
32MP0002723_abnormal_immune_serum1.65451424
33MP0004859_abnormal_synaptic_plasticity1.65184024
34MP0004233_abnormal_muscle_weight1.64915534
35MP0002452_abnormal_antigen_presenting1.64279731
36MP0004087_abnormal_muscle_fiber1.64015694
37MP0001545_abnormal_hematopoietic_system1.61172682
38MP0005397_hematopoietic_system_phenotyp1.61172682
39MP0000733_abnormal_muscle_development1.60385482
40MP0010630_abnormal_cardiac_muscle1.59960667
41MP0010352_gastrointestinal_tract_polyps1.59885199
42MP0003787_abnormal_imprinting1.59874491
43MP0006082_CNS_inflammation1.59504006
44MP0004808_abnormal_hematopoietic_stem1.58348757
45MP0002254_reproductive_system_inflammat1.58195977
46MP0001849_ear_inflammation1.58108819
47MP0004145_abnormal_muscle_electrophysio1.55681700
48MP0002998_abnormal_bone_remodeling1.52250875
49MP0004185_abnormal_adipocyte_glucose1.51098399
50MP0003646_muscle_fatigue1.49844026
51MP0002877_abnormal_melanocyte_morpholog1.45873225
52MP0005310_abnormal_salivary_gland1.43534193
53MP0004197_abnormal_fetal_growth/weight/1.43417963
54* MP0003984_embryonic_growth_retardation1.43395612
55MP0000858_altered_metastatic_potential1.41579719
56MP0005670_abnormal_white_adipose1.41393179
57* MP0002088_abnormal_embryonic_growth/wei1.40760956
58MP0010155_abnormal_intestine_physiology1.40190739
59MP0003077_abnormal_cell_cycle1.39488259
60MP0002420_abnormal_adaptive_immunity1.38862512
61MP0001819_abnormal_immune_cell1.38622279
62MP0010307_abnormal_tumor_latency1.37923025
63* MP0005380_embryogenesis_phenotype1.37815414
64* MP0001672_abnormal_embryogenesis/_devel1.37815414
65MP0003091_abnormal_cell_migration1.37439694
66MP0002106_abnormal_muscle_physiology1.35592872
67MP0000703_abnormal_thymus_morphology1.34418861
68MP0001533_abnormal_skeleton_physiology1.33115298
69MP0004084_abnormal_cardiac_muscle1.32510831
70MP0010094_abnormal_chromosome_stability1.32105252
71MP0003566_abnormal_cell_adhesion1.31379272
72MP0001853_heart_inflammation1.31271852
73MP0000604_amyloidosis1.30923302
74MP0001730_embryonic_growth_arrest1.28907210
75MP0005167_abnormal_blood-brain_barrier1.27894012
76MP0001873_stomach_inflammation1.27535556
77MP0003763_abnormal_thymus_physiology1.27472841
78MP0002084_abnormal_developmental_patter1.27230426
79MP0002396_abnormal_hematopoietic_system1.26329930
80MP0003075_altered_response_to1.22525374
81MP0001348_abnormal_lacrimal_gland1.22496283
82MP0000716_abnormal_immune_system1.21697648
83MP0003045_fibrosis1.18063597
84MP0003567_abnormal_fetal_cardiomyocyte1.17332318
85* MP0000350_abnormal_cell_proliferation1.16567807
86* MP0002086_abnormal_extraembryonic_tissu1.15630691
87MP0000750_abnormal_muscle_regeneration1.15325115
88MP0003656_abnormal_erythrocyte_physiolo1.14657841
89MP0009764_decreased_sensitivity_to1.14270833
90* MP0002925_abnormal_cardiovascular_devel1.14151511
91MP0001845_abnormal_inflammatory_respons1.12881235
92MP0005623_abnormal_meninges_morphology1.12386407
93MP0002269_muscular_atrophy1.12015773
94MP0002085_abnormal_embryonic_tissue1.11542287
95MP0008995_early_reproductive_senescence1.10636569
96MP0008770_decreased_survivor_rate1.10061142
97MP0002429_abnormal_blood_cell1.09190907
98MP0005666_abnormal_adipose_tissue1.08253603
99MP0003866_abnormal_defecation1.07792697
100MP0000759_abnormal_skeletal_muscle1.07711143
101MP0003115_abnormal_respiratory_system1.07127088
102MP0003828_pulmonary_edema1.06080044
103* MP0000266_abnormal_heart_morphology1.04005217
104MP0005375_adipose_tissue_phenotype1.03906846
105MP0005409_darkened_coat_color1.02834922
106MP0003448_altered_tumor_morphology1.02164203
107MP0008569_lethality_at_weaning1.01099505
108* MP0001697_abnormal_embryo_size1.00631858
109MP0008469_abnormal_protein_level1.00629598
110MP0001929_abnormal_gametogenesis1.00397900
111MP0008260_abnormal_autophagy0.99926762
112MP0002398_abnormal_bone_marrow0.98806801
113MP0000749_muscle_degeneration0.98601834
114MP0000678_abnormal_parathyroid_gland0.98433576
115MP0005369_muscle_phenotype0.97828291
116MP0003698_abnormal_male_reproductive0.97303665
117MP0000003_abnormal_adipose_tissue0.97048434
118MP0000685_abnormal_immune_system0.96962569
119* MP0002080_prenatal_lethality0.95187596
120MP0009672_abnormal_birth_weight0.94464790
121MP0003329_amyloid_beta_deposits0.93716816
122MP0001784_abnormal_fluid_regulation0.93248812
123MP0008004_abnormal_stomach_pH0.90708943
124MP0000689_abnormal_spleen_morphology0.88833228
125MP0009703_decreased_birth_body0.88826684
126MP0003878_abnormal_ear_physiology0.88320233
127MP0005377_hearing/vestibular/ear_phenot0.88320233
128MP0003724_increased_susceptibility_to0.86660707
129MP0009046_muscle_twitch0.86110080
130MP0002405_respiratory_system_inflammati0.85169142
131MP0002089_abnormal_postnatal_growth/wei0.85119928
132MP0000428_abnormal_craniofacial_morphol0.84796979
133MP0005330_cardiomyopathy0.83912836
134MP0003121_genomic_imprinting0.83726613
135MP0001915_intracranial_hemorrhage0.83577029
136MP0000343_altered_response_to0.81856621
137MP0001790_abnormal_immune_system0.81655856
138MP0005387_immune_system_phenotype0.81655856
139MP0005257_abnormal_intraocular_pressure0.80607146
140MP0003950_abnormal_plasma_membrane0.80537645
141MP0000747_muscle_weakness0.79338530
142MP0003861_abnormal_nervous_system0.78666273
143MP0001663_abnormal_digestive_system0.78233322
144MP0004858_abnormal_nervous_system0.78186886
145MP0003935_abnormal_craniofacial_develop0.78106179
146MP0006138_congestive_heart_failure0.77644461
147MP0003690_abnormal_glial_cell0.77010065
148MP0000490_abnormal_crypts_of0.76821519
149MP0004957_abnormal_blastocyst_morpholog0.76561926
150MP0001544_abnormal_cardiovascular_syste0.75365677
151MP0005385_cardiovascular_system_phenoty0.75365677
152MP0002249_abnormal_larynx_morphology0.74935838
153MP0005647_abnormal_sex_gland0.74311931
154MP0003123_paternal_imprinting0.73528564
155MP0002210_abnormal_sex_determination0.73287183
156MP0002933_joint_inflammation0.73099769
157MP0002722_abnormal_immune_system0.72578481
158MP0000609_abnormal_liver_physiology0.71718328
159MP0002138_abnormal_hepatobiliary_system0.71542465
160MP0002332_abnormal_exercise_endurance0.71188130
161MP0005464_abnormal_platelet_physiology0.70600603
162MP0000371_diluted_coat_color0.67768234
163* MP0005621_abnormal_cell_physiology0.65465505
164MP0004381_abnormal_hair_follicle0.64358473
165MP0005390_skeleton_phenotype0.63807852
166MP0009931_abnormal_skin_appearance0.61469521

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)3.56983901
2Increased cerebral lipofuscin (HP:0011813)3.51502049
3Abnormality of liposaccharide metabolism (HP:0010968)3.44882552
4Abnormality of glycosphingolipid metabolism (HP:0004343)3.44882552
5Abnormality of glycolipid metabolism (HP:0010969)3.44882552
6Dysmetric saccades (HP:0000641)3.41318849
7Increased neuronal autofluorescent lipopigment (HP:0002074)3.03610552
8Thin bony cortex (HP:0002753)2.98461811
9Abnormality of the lower motor neuron (HP:0002366)2.86879106
10Loss of speech (HP:0002371)2.80634490
11Hyperacusis (HP:0010780)2.79216878
12Broad face (HP:0000283)2.78458690
13Dysostosis multiplex (HP:0000943)2.77077887
14Autoimmune thrombocytopenia (HP:0001973)2.71861962
15Nuclear cataract (HP:0100018)2.71270188
16Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.69376053
17Genetic anticipation (HP:0003743)2.67612037
18Difficulty running (HP:0009046)2.67251604
19Heterotopia (HP:0002282)2.66670215
20Abnormality of macrophages (HP:0004311)2.56719504
21Abnormality of the thoracic spine (HP:0100711)2.52565265
22Trigonocephaly (HP:0000243)2.51202199
23Long eyelashes (HP:0000527)2.50812534
24Thoracic kyphosis (HP:0002942)2.49891902
25Increased density of long bones (HP:0006392)2.49638695
26Upper limb amyotrophy (HP:0009129)2.49119026
27Distal upper limb amyotrophy (HP:0007149)2.49119026
28Abnormality of the left ventricular outflow tract (HP:0011103)2.48781236
29Subaortic stenosis (HP:0001682)2.48781236
30Mediastinal lymphadenopathy (HP:0100721)2.43169480
31Urethral obstruction (HP:0000796)2.42540139
32Shallow orbits (HP:0000586)2.42061954
33Hemorrhage of the eye (HP:0011885)2.39785754
34Segmental peripheral demyelination/remyelination (HP:0003481)2.39619274
35Macroorchidism (HP:0000053)2.38348992
36Broad palm (HP:0001169)2.37805445
37Hypoplastic ischia (HP:0003175)2.37577949
38Obstructive sleep apnea (HP:0002870)2.33197881
39Cerebral aneurysm (HP:0004944)2.29753959
40Turricephaly (HP:0000262)2.29136728
41Supernumerary ribs (HP:0005815)2.25485379
42Eczematoid dermatitis (HP:0000976)2.25338783
43Neuronal loss in central nervous system (HP:0002529)2.21969622
44Distal lower limb amyotrophy (HP:0008944)2.19414700
45Narrow palate (HP:0000189)2.17986284
46Systemic lupus erythematosus (HP:0002725)2.17265076
47Hyporeflexia of lower limbs (HP:0002600)2.16997079
48Lower limb amyotrophy (HP:0007210)2.16751865
49Recurrent viral infections (HP:0004429)2.15531840
50Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.14205934
51Pointed chin (HP:0000307)2.13881540
52Colitis (HP:0002583)2.13790450
53Absent frontal sinuses (HP:0002688)2.13758011
54Short 4th metacarpal (HP:0010044)2.12575636
55Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.12575636
56Abnormality of mucopolysaccharide metabolism (HP:0011020)2.12085980
57Abnormality of polysaccharide metabolism (HP:0011012)2.12085980
58Abnormality of glycosaminoglycan metabolism (HP:0004371)2.12085980
59Increased connective tissue (HP:0009025)2.11603839
60Increased IgE level (HP:0003212)2.10567451
61Myocardial infarction (HP:0001658)2.08413921
62Difficulty climbing stairs (HP:0003551)2.06687645
63Neurofibrillary tangles (HP:0002185)2.06353166
64Increased serum ferritin (HP:0003281)2.04046374
65Cerebral inclusion bodies (HP:0100314)2.02872716
66Prominent nose (HP:0000448)2.02813000
67Gastrointestinal stroma tumor (HP:0100723)2.02053921
68Persistence of primary teeth (HP:0006335)2.01037957
69Emphysema (HP:0002097)2.00863626
70Hand muscle atrophy (HP:0009130)2.00795452
71Ectopic kidney (HP:0000086)1.99587383
72Mucopolysacchariduria (HP:0008155)1.99554815
73Urinary glycosaminoglycan excretion (HP:0003541)1.99554815
74Vacuolated lymphocytes (HP:0001922)1.99145021
75Ependymoma (HP:0002888)1.98113322
76Flat acetabular roof (HP:0003180)1.96986993
77Supernumerary bones of the axial skeleton (HP:0009144)1.96628265
78Cellulitis (HP:0100658)1.95155325
79Sudden death (HP:0001699)1.94603732
80Recurrent bacterial skin infections (HP:0005406)1.94309647
81Orchitis (HP:0100796)1.92251576
82Impaired smooth pursuit (HP:0007772)1.91420042
83Achilles tendon contracture (HP:0001771)1.90956502
84Hypertensive crisis (HP:0100735)1.90137856
85Increased nuchal translucency (HP:0010880)1.89582929
86Exercise-induced myalgia (HP:0003738)1.89487430
87Deep palmar crease (HP:0006191)1.87512347
88Abnormality of the lumbar spine (HP:0100712)1.87036695
89Apathy (HP:0000741)1.85735363
90Deep venous thrombosis (HP:0002625)1.85428622
91Astrocytoma (HP:0009592)1.85274782
92Abnormality of the astrocytes (HP:0100707)1.85274782
93Ulnar bowing (HP:0003031)1.85218343
94Flat occiput (HP:0005469)1.84922760
95Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.84491494
96Neoplasm of the heart (HP:0100544)1.83499770
97Oligodontia (HP:0000677)1.83281781
98Limited elbow extension (HP:0001377)1.81911835
99Retrobulbar optic neuritis (HP:0100654)1.81177539
100Optic neuritis (HP:0100653)1.81177539
101Personality changes (HP:0000751)1.81160928
102Annular pancreas (HP:0001734)1.80200793
103Metaphyseal cupping (HP:0003021)1.80052631
104Intestinal fistula (HP:0100819)1.80012803
105Abnormality of the ischium (HP:0003174)1.78903748
106Abnormality of ocular smooth pursuit (HP:0000617)1.78857303
107Abnormality of the columella (HP:0009929)1.77504550
108Elfin facies (HP:0004428)1.77328541
109Male infertility (HP:0003251)1.76991894
110Delayed epiphyseal ossification (HP:0002663)1.76742549
111Broad thumb (HP:0011304)1.75526138
112Skin tags (HP:0010609)1.74550356
113Skull defect (HP:0001362)1.74282842
114Anal stenosis (HP:0002025)1.74062998
115Supernumerary nipples (HP:0002558)1.73315065
116Bundle branch block (HP:0011710)1.73221115
117Pseudobulbar signs (HP:0002200)1.72696258
118Vertebral arch anomaly (HP:0008438)1.72016904
119Onion bulb formation (HP:0003383)1.71919216
120EMG: neuropathic changes (HP:0003445)1.71094769
121Abnormality of the distal phalanx of the thumb (HP:0009617)1.70481544
122Renovascular hypertension (HP:0100817)1.70436043
123Diminished motivation (HP:0000745)1.69723804
124Recurrent abscess formation (HP:0002722)1.69625655
125Axonal loss (HP:0003447)1.69280046
126Frequent falls (HP:0002359)1.68239229
127Insomnia (HP:0100785)1.67744864
128High pitched voice (HP:0001620)1.67481464
129Abnormality of the Achilles tendon (HP:0005109)1.67465766
130Renal duplication (HP:0000075)1.66922213
131Atrial fibrillation (HP:0005110)1.66881296
132Truncal obesity (HP:0001956)1.66784800
133Disinhibition (HP:0000734)1.65450226
134Depressed nasal tip (HP:0000437)1.65203724
135Overriding aorta (HP:0002623)1.65103429
136Chronic obstructive pulmonary disease (HP:0006510)1.64561834
137Obstructive lung disease (HP:0006536)1.64561834
138Thin ribs (HP:0000883)1.64070294
139J-shaped sella turcica (HP:0002680)1.63232189
140Patellar dislocation (HP:0002999)1.62065102
141Hemiplegia (HP:0002301)1.61516702
142Selective tooth agenesis (HP:0001592)1.61407707
143Bone pain (HP:0002653)1.60727931
144Myositis (HP:0100614)1.60553219
145Mask-like facies (HP:0000298)1.60474710
146Dislocated radial head (HP:0003083)1.59475192
147Obsessive-compulsive behavior (HP:0000722)1.59386659
148Restrictive lung disease (HP:0002091)1.58329740
149Interstitial pulmonary disease (HP:0006530)1.58032627
150Hip contracture (HP:0003273)1.57427099
151Broad phalanges of the hand (HP:0009768)1.57244689
152Asymmetry of the thorax (HP:0001555)1.56789381
153Neoplasm of the oral cavity (HP:0100649)1.56771335
154Slow saccadic eye movements (HP:0000514)1.56406587
155Recurrent fungal infections (HP:0002841)1.56135213
156Abnormality of chromosome segregation (HP:0002916)1.56010728
157Primary atrial arrhythmia (HP:0001692)1.55935240
158Acrocyanosis (HP:0001063)1.55618136
159Proximal amyotrophy (HP:0007126)1.55197798
160Abnormality of the 4th metacarpal (HP:0010012)1.53177966
161Genu recurvatum (HP:0002816)1.51882847
162Broad metatarsal (HP:0001783)1.51745433
163Reticulocytosis (HP:0001923)1.50957837
164Muscle fiber splitting (HP:0003555)1.50119940
165Short phalanx of the thumb (HP:0009660)1.49991621
166Mildly elevated creatine phosphokinase (HP:0008180)1.48656473
167Volvulus (HP:0002580)1.48365319
168Long palpebral fissure (HP:0000637)1.47860208
169Rib fusion (HP:0000902)1.46098148
170Disproportionate tall stature (HP:0001519)1.45919083
171Abnormality of the radial head (HP:0003995)1.45663228
172Oligodactyly (HP:0012165)1.45212695
173Spinal muscular atrophy (HP:0007269)1.44399972
174Exercise-induced muscle cramps (HP:0003710)1.44196001
175Supraventricular arrhythmia (HP:0005115)1.44089756
176Stomatitis (HP:0010280)1.43322544
177Supraventricular tachycardia (HP:0004755)1.42794620

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.29400042
2IRAK34.32648506
3PRPF4B3.48097069
4MAP3K103.43957393
5ICK3.35997199
6TRIB33.08882529
7EEF2K2.96468154
8SMG12.86300697
9PRKD32.37277071
10BRD42.30207686
11RIPK12.18499862
12TAOK12.15516495
13MAP4K12.11377598
14SIK22.03684317
15NME22.01579987
16CAMK1G1.89310769
17DMPK1.88513544
18FGFR41.85427678
19MARK21.76831003
20PKN21.74103451
21TYRO31.71887362
22TTN1.64252320
23MTOR1.60510792
24NEK21.59428235
25ALK1.59257746
26RIPK41.50139693
27BMX1.48612542
28IRAK41.36983413
29TBK11.31592241
30MAP3K131.31176454
31LATS11.28900249
32MATK1.27865682
33EPHB11.26836857
34MAP3K71.26372714
35CDK41.23516474
36PNCK1.22028276
37PTK61.21391694
38CDC71.20677397
39CAMK1D1.13735121
40WNK11.12582768
41CDC42BPA1.08992916
42BLK1.06056151
43STK381.03130323
44PIM21.03074558
45CHUK0.99758476
46CHEK10.97372949
47IKBKB0.96792012
48CDK60.96470679
49MAPK110.94166313
50FGR0.91931033
51JAK30.89971477
52MAP2K30.89025745
53PDGFRB0.85674146
54TTK0.84949024
55SIK10.83941862
56CDK90.82789475
57RPS6KC10.82402403
58RPS6KL10.82402403
59IRAK20.82366645
60PAK20.81328467
61TYK20.80649373
62RPS6KA20.77012111
63MKNK20.76597567
64STK100.76190120
65PDGFRA0.76171638
66HCK0.75888714
67ERN10.75869733
68PRKCH0.74042229
69PAK60.73760534
70CDK20.73529845
71MAP3K10.73327138
72FGFR30.73029316
73IKBKE0.72584683
74PIM10.68932722
75SIK30.67693952
76RPS6KA60.67419517
77STK30.67416577
78SGK30.67128776
79CAMK40.65923253
80MAP3K30.65394516
81CDK70.63488108
82PDPK10.63459768
83NTRK20.60281035
84PRKD20.59736076
85PTK2B0.59572322
86ATM0.59321984
87MAPK80.58177960
88DDR20.58030722
89MOS0.57682853
90MAPK100.57275477
91LATS20.56762188
92CLK10.56251892
93MARK30.55874928
94GSK3B0.55814423
95GRK70.53706439
96CSNK1D0.53561020
97PTK20.53346681
98RPS6KA10.52835899
99MAP3K110.52435601
100UHMK10.52385790
101ATR0.52229025
102ITK0.51694828
103MAPK140.51601913
104MAP3K140.51542341
105MAPK10.50069080
106PRKDC0.49801858
107TESK20.49747106
108STK110.49622032
109CDK10.49232786
110ZAP700.48037599
111PRKAA20.47670975
112MAP3K80.47502469
113SGK10.47439303
114KSR20.46977709
115FGFR10.45821377
116MAP3K60.45724415
117BTK0.45452534
118CSF1R0.45186292
119CSK0.43946187
120TXK0.43655623
121PDK30.43583708
122PDK40.43583708
123CHEK20.43308210
124DYRK1B0.42842284
125MAP2K20.42395403
126HIPK20.41784167
127TAOK20.41635337
128CAMKK10.41041132
129RPS6KA40.40840766
130RPS6KA30.40468712
131CSNK1E0.39916703
132GRK60.39735782
133PDK10.39398114
134PRKAA10.37125120
135IRAK10.36587527
136MAPK150.36274884
137MAP2K60.36033675
138MAPK70.36007996
139TNK20.35775906
140MAPK40.35277583
141SYK0.34960923
142MAPK120.32255439
143MELK0.29937795
144CDK11A0.29833094
145MAPK30.29427395
146LYN0.28094279

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.96334066
2Toll-like receptor signaling pathway_Homo sapiens_hsa046202.33148906
3Bladder cancer_Homo sapiens_hsa052191.91837039
4Dorso-ventral axis formation_Homo sapiens_hsa043201.70366140
5mRNA surveillance pathway_Homo sapiens_hsa030151.61765497
6Notch signaling pathway_Homo sapiens_hsa043301.60860730
7Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.59184935
8Chronic myeloid leukemia_Homo sapiens_hsa052201.58765458
9Prion diseases_Homo sapiens_hsa050201.58764098
10RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.51211513
11* Lysine degradation_Homo sapiens_hsa003101.49345395
12NOD-like receptor signaling pathway_Homo sapiens_hsa046211.47789379
13Malaria_Homo sapiens_hsa051441.43369334
14Type II diabetes mellitus_Homo sapiens_hsa049301.42943930
15Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.42858618
16T cell receptor signaling pathway_Homo sapiens_hsa046601.42149282
17Lysosome_Homo sapiens_hsa041421.41775960
18Thyroid hormone signaling pathway_Homo sapiens_hsa049191.38177040
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.37961261
20Allograft rejection_Homo sapiens_hsa053301.37120926
21mTOR signaling pathway_Homo sapiens_hsa041501.34598618
22Acute myeloid leukemia_Homo sapiens_hsa052211.34246620
23B cell receptor signaling pathway_Homo sapiens_hsa046621.33929188
24Tuberculosis_Homo sapiens_hsa051521.32642109
25MicroRNAs in cancer_Homo sapiens_hsa052061.31281393
26Dilated cardiomyopathy_Homo sapiens_hsa054141.30945922
27Glycosaminoglycan degradation_Homo sapiens_hsa005311.29298317
28Salmonella infection_Homo sapiens_hsa051321.26139141
29Graft-versus-host disease_Homo sapiens_hsa053321.24244105
30Hepatitis C_Homo sapiens_hsa051601.23777294
31Viral myocarditis_Homo sapiens_hsa054161.23406719
32Pertussis_Homo sapiens_hsa051331.22670035
33NF-kappa B signaling pathway_Homo sapiens_hsa040641.22016363
34Phosphatidylinositol signaling system_Homo sapiens_hsa040701.21796221
35Asthma_Homo sapiens_hsa053101.21580234
36Osteoclast differentiation_Homo sapiens_hsa043801.21144519
37Neurotrophin signaling pathway_Homo sapiens_hsa047221.19419652
38Rheumatoid arthritis_Homo sapiens_hsa053231.17713438
39Small cell lung cancer_Homo sapiens_hsa052221.15742062
40Staphylococcus aureus infection_Homo sapiens_hsa051501.14687088
41Long-term potentiation_Homo sapiens_hsa047201.11871116
42Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.11826638
43Legionellosis_Homo sapiens_hsa051341.10491889
44Adherens junction_Homo sapiens_hsa045201.10322115
45Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.10172832
46Longevity regulating pathway - mammal_Homo sapiens_hsa042111.10086896
47Fructose and mannose metabolism_Homo sapiens_hsa000511.09083721
48Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.08621557
49African trypanosomiasis_Homo sapiens_hsa051431.08547265
50HTLV-I infection_Homo sapiens_hsa051661.07942805
51MAPK signaling pathway_Homo sapiens_hsa040101.07659075
52VEGF signaling pathway_Homo sapiens_hsa043701.07323975
53Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.06637646
54Aldosterone synthesis and secretion_Homo sapiens_hsa049251.02524264
55Central carbon metabolism in cancer_Homo sapiens_hsa052301.02473380
56Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.00792147
57Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.99439318
58Proteoglycans in cancer_Homo sapiens_hsa052050.98286209
59Carbohydrate digestion and absorption_Homo sapiens_hsa049730.98247664
60Primary immunodeficiency_Homo sapiens_hsa053400.96879511
61Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.96188834
62Estrogen signaling pathway_Homo sapiens_hsa049150.95902133
63Glioma_Homo sapiens_hsa052140.94115671
64cGMP-PKG signaling pathway_Homo sapiens_hsa040220.94093145
65Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.93666523
66Insulin resistance_Homo sapiens_hsa049310.93327843
67Phospholipase D signaling pathway_Homo sapiens_hsa040720.93053623
68Oxytocin signaling pathway_Homo sapiens_hsa049210.93031288
69Regulation of actin cytoskeleton_Homo sapiens_hsa048100.92943604
70Renal cell carcinoma_Homo sapiens_hsa052110.92940658
71HIF-1 signaling pathway_Homo sapiens_hsa040660.92374301
72Autoimmune thyroid disease_Homo sapiens_hsa053200.92077826
73Epstein-Barr virus infection_Homo sapiens_hsa051690.91686762
74Toxoplasmosis_Homo sapiens_hsa051450.91487714
75AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.91458664
76Inositol phosphate metabolism_Homo sapiens_hsa005620.91062487
77ErbB signaling pathway_Homo sapiens_hsa040120.90697362
78Non-small cell lung cancer_Homo sapiens_hsa052230.90172684
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.89119838
80RNA transport_Homo sapiens_hsa030130.88921224
81Focal adhesion_Homo sapiens_hsa045100.87441498
82Pancreatic cancer_Homo sapiens_hsa052120.86536540
83cAMP signaling pathway_Homo sapiens_hsa040240.85752036
84Herpes simplex infection_Homo sapiens_hsa051680.85631200
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.85399884
86Measles_Homo sapiens_hsa051620.84777469
87Prolactin signaling pathway_Homo sapiens_hsa049170.83365666
88Hepatitis B_Homo sapiens_hsa051610.81753016
89Circadian entrainment_Homo sapiens_hsa047130.81714613
90Colorectal cancer_Homo sapiens_hsa052100.81029585
91Endometrial cancer_Homo sapiens_hsa052130.80873856
92Prostate cancer_Homo sapiens_hsa052150.78271457
93Glutamatergic synapse_Homo sapiens_hsa047240.78188311
94Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.77881025
95Choline metabolism in cancer_Homo sapiens_hsa052310.77373181
96Oocyte meiosis_Homo sapiens_hsa041140.77178535
97TNF signaling pathway_Homo sapiens_hsa046680.76847045
98Fatty acid biosynthesis_Homo sapiens_hsa000610.76833522
99Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.76489091
100Amoebiasis_Homo sapiens_hsa051460.74796652
101Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.74164354
102Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73965560
103Type I diabetes mellitus_Homo sapiens_hsa049400.73855946
104Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.73496912
105GnRH signaling pathway_Homo sapiens_hsa049120.72841792
106Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.72224797
107Jak-STAT signaling pathway_Homo sapiens_hsa046300.72079248
108Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71178340
109AMPK signaling pathway_Homo sapiens_hsa041520.70361613
110* Transcriptional misregulation in cancer_Homo sapiens_hsa052020.69804475
111Influenza A_Homo sapiens_hsa051640.69463917
112Apoptosis_Homo sapiens_hsa042100.69003601
113Chemokine signaling pathway_Homo sapiens_hsa040620.68337454
114Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.68308343
115Cell cycle_Homo sapiens_hsa041100.68215030
116Insulin signaling pathway_Homo sapiens_hsa049100.68110210
117Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.68001142
118Glucagon signaling pathway_Homo sapiens_hsa049220.67967183
119Long-term depression_Homo sapiens_hsa047300.67711616
120Viral carcinogenesis_Homo sapiens_hsa052030.67475752
121Hippo signaling pathway_Homo sapiens_hsa043900.67315589
122Circadian rhythm_Homo sapiens_hsa047100.67269573
123Basal cell carcinoma_Homo sapiens_hsa052170.67256116
124Cyanoamino acid metabolism_Homo sapiens_hsa004600.67167566
125Antigen processing and presentation_Homo sapiens_hsa046120.66787331
126Leishmaniasis_Homo sapiens_hsa051400.66288711
127Platelet activation_Homo sapiens_hsa046110.65995303
128FoxO signaling pathway_Homo sapiens_hsa040680.65007524
129Rap1 signaling pathway_Homo sapiens_hsa040150.64798202
130Shigellosis_Homo sapiens_hsa051310.64525787
131Hematopoietic cell lineage_Homo sapiens_hsa046400.64125795
132Spliceosome_Homo sapiens_hsa030400.63279924
133Sphingolipid signaling pathway_Homo sapiens_hsa040710.62052383
134Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56197521
135Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55624364
136Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53832327
137Sphingolipid metabolism_Homo sapiens_hsa006000.48069748
138Galactose metabolism_Homo sapiens_hsa000520.46818424

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