DPCD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene in mouse encodes a protein that may be involved in the generation and maintenance of ciliated cells. In mouse, expression of this gene increases during ciliated cell differentiation, and disruption of this gene has been linked to primary ciliary dyskinesia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.36498412
2axonemal dynein complex assembly (GO:0070286)6.17139088
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.73693230
4ATP synthesis coupled proton transport (GO:0015986)5.73693230
5* epithelial cilium movement (GO:0003351)5.43328145
6epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.21407765
7ribosomal small subunit assembly (GO:0000028)5.19927384
8establishment of protein localization to mitochondrial membrane (GO:0090151)5.13638347
9* cilium movement (GO:0003341)5.13271551
10viral transcription (GO:0019083)5.11404809
11mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.09548242
12translational termination (GO:0006415)4.95666769
13protein neddylation (GO:0045116)4.71398406
14intraciliary transport (GO:0042073)4.65375144
15respiratory electron transport chain (GO:0022904)4.63640745
16SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.63216462
17cotranslational protein targeting to membrane (GO:0006613)4.61867081
18chaperone-mediated protein transport (GO:0072321)4.61714597
19electron transport chain (GO:0022900)4.57872326
20protein targeting to ER (GO:0045047)4.52653965
21establishment of protein localization to endoplasmic reticulum (GO:0072599)4.34967531
22protein localization to endoplasmic reticulum (GO:0070972)4.27279803
23translational elongation (GO:0006414)4.19133107
24maturation of SSU-rRNA (GO:0030490)4.04660774
25protein complex biogenesis (GO:0070271)4.01419100
26ribosomal small subunit biogenesis (GO:0042274)4.01281846
27regulation of cilium movement (GO:0003352)3.99568618
28mitochondrial respiratory chain complex I assembly (GO:0032981)3.92390477
29NADH dehydrogenase complex assembly (GO:0010257)3.92390477
30mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.92390477
31cellular protein complex disassembly (GO:0043624)3.89041363
32motile cilium assembly (GO:0044458)3.86560104
33sequestering of actin monomers (GO:0042989)3.85980468
34viral life cycle (GO:0019058)3.83362751
35nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.73803245
36mitochondrial respiratory chain complex assembly (GO:0033108)3.70418943
37GTP biosynthetic process (GO:0006183)3.65285737
38translational initiation (GO:0006413)3.61295857
39cilium or flagellum-dependent cell motility (GO:0001539)3.59761369
40purine nucleoside triphosphate biosynthetic process (GO:0009145)3.46745260
41purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.46226675
42nonmotile primary cilium assembly (GO:0035058)3.40536006
43ATP biosynthetic process (GO:0006754)3.40208024
44protein complex disassembly (GO:0043241)3.30789530
45regulation of mitochondrial translation (GO:0070129)3.29615486
46ribosomal large subunit biogenesis (GO:0042273)3.27941448
47tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.23785744
48RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.23785744
49translation (GO:0006412)3.21836697
50axoneme assembly (GO:0035082)3.21669712
51macromolecular complex disassembly (GO:0032984)3.19076816
52cullin deneddylation (GO:0010388)3.16934703
53cilium morphogenesis (GO:0060271)3.14843059
54UTP biosynthetic process (GO:0006228)3.14753117
55protein targeting to membrane (GO:0006612)3.13343986
56inner mitochondrial membrane organization (GO:0007007)3.12692260
57cilium organization (GO:0044782)3.10139870
58proteasome assembly (GO:0043248)3.09627802
59cilium assembly (GO:0042384)3.07131489
60ribonucleoside triphosphate biosynthetic process (GO:0009201)3.05547327
61nucleoside diphosphate phosphorylation (GO:0006165)3.04860999
62hydrogen ion transmembrane transport (GO:1902600)3.03840892
63chromatin remodeling at centromere (GO:0031055)3.01028876
64pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.00454371
65nucleoside triphosphate biosynthetic process (GO:0009142)2.98690685
66CENP-A containing nucleosome assembly (GO:0034080)2.91068410
67intracellular protein transmembrane import (GO:0044743)2.90799817
68guanosine-containing compound biosynthetic process (GO:1901070)2.88475485
69protein deneddylation (GO:0000338)2.85602870
70UTP metabolic process (GO:0046051)2.85114319
71transcription elongation from RNA polymerase III promoter (GO:0006385)2.84873168
72termination of RNA polymerase III transcription (GO:0006386)2.84873168
73* left/right pattern formation (GO:0060972)2.82711529
74DNA damage response, detection of DNA damage (GO:0042769)2.80339089
75nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.78625409
76nuclear-transcribed mRNA catabolic process (GO:0000956)2.78035627
77oxidative phosphorylation (GO:0006119)2.71368664
78proton transport (GO:0015992)2.70765774
79negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.69778524
80aldehyde catabolic process (GO:0046185)2.68875135
81protein targeting to mitochondrion (GO:0006626)2.65054778
82establishment of protein localization to mitochondrion (GO:0072655)2.64450557
83exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.63886195
84respiratory chain complex IV assembly (GO:0008535)2.63694313
85protein localization to mitochondrion (GO:0070585)2.63636761
86hydrogen transport (GO:0006818)2.63590748
87CTP biosynthetic process (GO:0006241)2.63199043
88CTP metabolic process (GO:0046036)2.63199043
89mRNA catabolic process (GO:0006402)2.61731246
90base-excision repair, AP site formation (GO:0006285)2.61110294
91cellular component biogenesis (GO:0044085)2.59800057
92organelle disassembly (GO:1903008)2.56204352
93protein localization to cilium (GO:0061512)2.53643818
94platelet dense granule organization (GO:0060155)2.50629840
95establishment of integrated proviral latency (GO:0075713)2.49604220
96rRNA modification (GO:0000154)2.48632696
97pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.48560229
98cytochrome complex assembly (GO:0017004)2.48425027
99centriole replication (GO:0007099)2.48111467
100spliceosomal snRNP assembly (GO:0000387)2.47935153

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human4.32556603
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.20311569
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.73859017
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.54296006
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.14383574
6CREB1_15753290_ChIP-ChIP_HEK293T_Human2.97174619
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.94875508
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.73545034
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.73183276
10CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.53146382
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.36502852
12NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.33022764
13ELK1_19687146_ChIP-ChIP_HELA_Human2.32819011
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.22534481
15EZH2_22144423_ChIP-Seq_EOC_Human2.20063298
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.17476949
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.07194583
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.97683675
19XRN2_22483619_ChIP-Seq_HELA_Human1.92073120
20VDR_23849224_ChIP-Seq_CD4+_Human1.89306561
21THAP11_20581084_ChIP-Seq_MESCs_Mouse1.88851241
22MYC_18358816_ChIP-ChIP_MESCs_Mouse1.88717920
23TTF2_22483619_ChIP-Seq_HELA_Human1.85743041
24EWS_26573619_Chip-Seq_HEK293_Human1.80441346
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.79424277
26MYC_18940864_ChIP-ChIP_HL60_Human1.78368409
27PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.75614539
28FUS_26573619_Chip-Seq_HEK293_Human1.75479438
29SRF_21415370_ChIP-Seq_HL-1_Mouse1.68126751
30ZNF274_21170338_ChIP-Seq_K562_Hela1.68064818
31ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.66780921
32E2F1_18555785_ChIP-Seq_MESCs_Mouse1.65593339
33MYC_19030024_ChIP-ChIP_MESCs_Mouse1.65151692
34YY1_21170310_ChIP-Seq_MESCs_Mouse1.63604240
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.62890891
36E2F4_17652178_ChIP-ChIP_JURKAT_Human1.62793094
37GABP_19822575_ChIP-Seq_HepG2_Human1.62221557
38MYC_19079543_ChIP-ChIP_MESCs_Mouse1.61636979
39DCP1A_22483619_ChIP-Seq_HELA_Human1.59559930
40* FOXP3_21729870_ChIP-Seq_TREG_Human1.51957513
41POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.50236929
42EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.46427033
43POU5F1_16153702_ChIP-ChIP_HESCs_Human1.42494512
44VDR_22108803_ChIP-Seq_LS180_Human1.39976201
45CBX2_27304074_Chip-Seq_ESCs_Mouse1.39363284
46SOX2_16153702_ChIP-ChIP_HESCs_Human1.38157077
47PADI4_21655091_ChIP-ChIP_MCF-7_Human1.35897109
48BMI1_23680149_ChIP-Seq_NPCS_Mouse1.31690605
49RNF2_27304074_Chip-Seq_NSC_Mouse1.30819537
50FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.30596504
51RBPJ_22232070_ChIP-Seq_NCS_Mouse1.30478064
52SOX2_18555785_ChIP-Seq_MESCs_Mouse1.29054590
53NANOG_16153702_ChIP-ChIP_HESCs_Human1.28202165
54* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.26553865
55CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.23680744
56PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23208540
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.21679707
58CTBP2_25329375_ChIP-Seq_LNCAP_Human1.20060595
59YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18913769
60FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.18263963
61MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.18193665
62ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.12505212
63NELFA_20434984_ChIP-Seq_ESCs_Mouse1.10393688
64MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.09855679
65ELK1_22589737_ChIP-Seq_MCF10A_Human1.09735579
66* P300_19829295_ChIP-Seq_ESCs_Human1.08959652
67TAF15_26573619_Chip-Seq_HEK293_Human1.06290362
68EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.05376382
69KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.04767052
70GBX2_23144817_ChIP-Seq_PC3_Human1.01311838
71EZH2_27304074_Chip-Seq_ESCs_Mouse0.98087775
72DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.97853240
73TP53_22573176_ChIP-Seq_HFKS_Human0.97576412
74CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.97569201
75GATA1_26923725_Chip-Seq_HPCs_Mouse0.97510850
76CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.96997229
77IRF1_19129219_ChIP-ChIP_H3396_Human0.96769142
78GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96546569
79CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.94249031
80SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.93687599
81TP63_19390658_ChIP-ChIP_HaCaT_Human0.93589175
82POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.93422198
83* ZFP57_27257070_Chip-Seq_ESCs_Mouse0.93184856
84PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.91346961
85CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.89264294
86FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.89012177
87ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.87882507
88HOXB4_20404135_ChIP-ChIP_EML_Mouse0.87429087
89EED_16625203_ChIP-ChIP_MESCs_Mouse0.86097399
90POU3F2_20337985_ChIP-ChIP_501MEL_Human0.85047301
91ELF1_17652178_ChIP-ChIP_JURKAT_Human0.83266763
92GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.82464738
93CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.80143085
94CTCF_18555785_ChIP-Seq_MESCs_Mouse0.78248944
95RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.76467352
96MYCN_18555785_ChIP-Seq_MESCs_Mouse0.76449500
97FLI1_27457419_Chip-Seq_LIVER_Mouse0.76434458
98IGF1R_20145208_ChIP-Seq_DFB_Human0.76408612
99TOP2B_26459242_ChIP-Seq_MCF-7_Human0.75745168
100KDM5A_27292631_Chip-Seq_BREAST_Human0.75566060

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation3.45263764
2MP0010030_abnormal_orbit_morphology3.14144810
3MP0003136_yellow_coat_color3.12223891
4MP0002653_abnormal_ependyma_morphology2.94652877
5MP0006292_abnormal_olfactory_placode2.91355537
6MP0008789_abnormal_olfactory_epithelium2.77578250
7MP0003880_abnormal_central_pattern2.51073967
8MP0005499_abnormal_olfactory_system2.36661040
9MP0005394_taste/olfaction_phenotype2.36661040
10MP0001529_abnormal_vocalization2.36635372
11MP0002938_white_spotting2.29650700
12MP0004133_heterotaxia2.13813590
13MP0000566_synostosis2.06670783
14MP0003122_maternal_imprinting2.06532682
15MP0001984_abnormal_olfaction2.03914089
16MP0001293_anophthalmia2.03655896
17MP0006276_abnormal_autonomic_nervous1.95180199
18MP0005084_abnormal_gallbladder_morpholo1.81787735
19MP0002233_abnormal_nose_morphology1.73596892
20MP0002102_abnormal_ear_morphology1.70587975
21MP0000049_abnormal_middle_ear1.69626113
22MP0008058_abnormal_DNA_repair1.67284276
23MP0002234_abnormal_pharynx_morphology1.66936859
24MP0006072_abnormal_retinal_apoptosis1.63173434
25MP0000778_abnormal_nervous_system1.61463659
26MP0003937_abnormal_limbs/digits/tail_de1.51124603
27MP0008995_early_reproductive_senescence1.45479060
28MP0003186_abnormal_redox_activity1.44096718
29MP0003121_genomic_imprinting1.42440419
30MP0005377_hearing/vestibular/ear_phenot1.33543565
31MP0003878_abnormal_ear_physiology1.33543565
32MP0004142_abnormal_muscle_tone1.33363455
33MP0003011_delayed_dark_adaptation1.32621698
34MP0002282_abnormal_trachea_morphology1.31932074
35MP0002160_abnormal_reproductive_system1.28018798
36MP0002163_abnormal_gland_morphology1.27014666
37MP0003890_abnormal_embryonic-extraembry1.25762348
38MP0008932_abnormal_embryonic_tissue1.25043510
39MP0001286_abnormal_eye_development1.24056709
40MP0002638_abnormal_pupillary_reflex1.23770706
41MP0000631_abnormal_neuroendocrine_gland1.23611377
42MP0000026_abnormal_inner_ear1.22549367
43MP0006035_abnormal_mitochondrial_morpho1.22070522
44MP0003938_abnormal_ear_development1.21902356
45MP0001485_abnormal_pinna_reflex1.19857100
46MP0008877_abnormal_DNA_methylation1.16012970
47MP0003942_abnormal_urinary_system1.15331468
48MP0003315_abnormal_perineum_morphology1.15173846
49MP0002736_abnormal_nociception_after1.14046262
50MP0002697_abnormal_eye_size1.13396672
51MP0005187_abnormal_penis_morphology1.12502941
52MP0000372_irregular_coat_pigmentation1.12076347
53MP0003718_maternal_effect1.11586093
54MP0003123_paternal_imprinting1.10027266
55MP0002751_abnormal_autonomic_nervous1.08737964
56MP0005253_abnormal_eye_physiology1.08016038
57MP0002822_catalepsy1.07702220
58MP0001346_abnormal_lacrimal_gland1.07094881
59MP0005551_abnormal_eye_electrophysiolog1.06130756
60MP0003755_abnormal_palate_morphology1.05626259
61MP0002752_abnormal_somatic_nervous1.04014210
62MP0001299_abnormal_eye_distance/1.03200941
63MP0001188_hyperpigmentation1.00988796
64MP0003119_abnormal_digestive_system0.99771412
65MP0004957_abnormal_blastocyst_morpholog0.99663803
66MP0006036_abnormal_mitochondrial_physio0.98856478
67MP0003861_abnormal_nervous_system0.98475308
68MP0000955_abnormal_spinal_cord0.96800784
69MP0002734_abnormal_mechanical_nocicepti0.96402574
70MP0002557_abnormal_social/conspecific_i0.94112970
71MP0002210_abnormal_sex_determination0.93419862
72MP0005391_vision/eye_phenotype0.93381299
73MP0005195_abnormal_posterior_eye0.93146560
74MP0001905_abnormal_dopamine_level0.92927124
75MP0002277_abnormal_respiratory_mucosa0.90877657
76MP0002090_abnormal_vision0.89764098
77MP0003786_premature_aging0.89642409
78MP0000647_abnormal_sebaceous_gland0.89444460
79MP0002184_abnormal_innervation0.88736089
80MP0001968_abnormal_touch/_nociception0.88533972
81MP0001324_abnormal_eye_pigmentation0.87967415
82MP0008875_abnormal_xenobiotic_pharmacok0.87247949
83MP0009046_muscle_twitch0.84514635
84MP0000537_abnormal_urethra_morphology0.83801949
85MP0003787_abnormal_imprinting0.82836653
86MP0005248_abnormal_Harderian_gland0.82489896
87MP0002928_abnormal_bile_duct0.82147311
88MP0002272_abnormal_nervous_system0.81958361
89MP0002837_dystrophic_cardiac_calcinosis0.80308151
90MP0005646_abnormal_pituitary_gland0.80299113
91MP0005389_reproductive_system_phenotype0.78852958
92MP0001929_abnormal_gametogenesis0.78253418
93MP0005423_abnormal_somatic_nervous0.78117037
94MP0000358_abnormal_cell_content/0.77809098
95MP0001963_abnormal_hearing_physiology0.76788081
96MP0002152_abnormal_brain_morphology0.75874181
97MP0002295_abnormal_pulmonary_circulatio0.75194650
98MP0002111_abnormal_tail_morphology0.74118661
99MP0000653_abnormal_sex_gland0.73755186
100MP0003698_abnormal_male_reproductive0.73649655

Predicted human phenotypes

RankGene SetZ-score
1Abnormal ciliary motility (HP:0012262)5.43315783
2Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.38591950
3Abnormal respiratory motile cilium physiology (HP:0012261)5.27702498
4Abnormal respiratory epithelium morphology (HP:0012253)5.18362409
5Abnormal respiratory motile cilium morphology (HP:0005938)5.18362409
6Absent/shortened dynein arms (HP:0200106)4.58136894
7Dynein arm defect of respiratory motile cilia (HP:0012255)4.58136894
8Rhinitis (HP:0012384)4.46861401
9Acute necrotizing encephalopathy (HP:0006965)4.46212783
10Abnormal mitochondria in muscle tissue (HP:0008316)4.04762477
11Pancreatic fibrosis (HP:0100732)3.89335268
12True hermaphroditism (HP:0010459)3.88948749
13Acute encephalopathy (HP:0006846)3.86563171
14Mitochondrial inheritance (HP:0001427)3.80475571
15Reticulocytopenia (HP:0001896)3.68638332
16Molar tooth sign on MRI (HP:0002419)3.63280119
17Abnormality of midbrain morphology (HP:0002418)3.63280119
18Progressive macrocephaly (HP:0004481)3.57630562
19Medial flaring of the eyebrow (HP:0010747)3.53981847
20Pancreatic cysts (HP:0001737)3.42600122
21Increased hepatocellular lipid droplets (HP:0006565)3.33919671
22Increased CSF lactate (HP:0002490)3.30126229
23Hepatocellular necrosis (HP:0001404)3.23294943
24Gait imbalance (HP:0002141)3.21957448
25Congenital primary aphakia (HP:0007707)3.20311979
26Nephronophthisis (HP:0000090)3.17565805
27Occipital encephalocele (HP:0002085)3.07307141
28Abnormality of cells of the erythroid lineage (HP:0012130)3.06102390
29Chronic bronchitis (HP:0004469)3.04641193
30Renal Fanconi syndrome (HP:0001994)3.01595052
31Abnormal number of erythroid precursors (HP:0012131)2.98281651
32Lipid accumulation in hepatocytes (HP:0006561)2.94255820
33Nephrogenic diabetes insipidus (HP:0009806)2.90831694
34Hepatic necrosis (HP:0002605)2.90337641
353-Methylglutaconic aciduria (HP:0003535)2.84985304
36Sclerocornea (HP:0000647)2.83739473
37Cerebral edema (HP:0002181)2.81694348
38Macrocytic anemia (HP:0001972)2.63547719
39Aplasia/Hypoplasia of the sacrum (HP:0008517)2.58248475
40Vaginal atresia (HP:0000148)2.56532600
41Anencephaly (HP:0002323)2.55827146
42Aplasia/Hypoplasia of the tongue (HP:0010295)2.55535912
43Cystic liver disease (HP:0006706)2.53059301
44Genital tract atresia (HP:0001827)2.50948660
45Bronchiectasis (HP:0002110)2.49475659
46Postaxial foot polydactyly (HP:0001830)2.45884453
47Abnormality of the renal medulla (HP:0100957)2.36213596
48Myokymia (HP:0002411)2.31170900
49Septo-optic dysplasia (HP:0100842)2.28583254
50Colon cancer (HP:0003003)2.25442829
51Decreased activity of mitochondrial respiratory chain (HP:0008972)2.24437164
52Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.24437164
53Male pseudohermaphroditism (HP:0000037)2.22484714
54Exercise intolerance (HP:0003546)2.22375602
55Hyperglycinemia (HP:0002154)2.22077931
56Optic disc pallor (HP:0000543)2.22061323
57Poor coordination (HP:0002370)2.20349862
58Chronic hepatic failure (HP:0100626)2.17657534
59Postaxial hand polydactyly (HP:0001162)2.17003786
60Increased intramyocellular lipid droplets (HP:0012240)2.11809082
61Abnormality of the labia minora (HP:0012880)2.09811857
62Respiratory failure (HP:0002878)2.09701607
63Preaxial hand polydactyly (HP:0001177)2.06629448
64Lactic acidosis (HP:0003128)2.05815544
65Congenital hepatic fibrosis (HP:0002612)2.05319993
66Anophthalmia (HP:0000528)2.04184819
67Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.00996597
68Abnormality of renal resorption (HP:0011038)1.97619257
69Bifid tongue (HP:0010297)1.97195063
70Leukodystrophy (HP:0002415)1.94865817
71Polyphagia (HP:0002591)1.91633879
72Increased serum lactate (HP:0002151)1.90794395
73Exertional dyspnea (HP:0002875)1.90742618
74Tubulointerstitial nephritis (HP:0001970)1.88246312
75Chronic sinusitis (HP:0011109)1.83230352
76Decreased testicular size (HP:0008734)1.79813883
77Infertility (HP:0000789)1.79383079
78Supernumerary spleens (HP:0009799)1.78387813
79Aplasia/Hypoplasia of the lens (HP:0008063)1.76391635
80Stenosis of the external auditory canal (HP:0000402)1.76151323
81Nasal polyposis (HP:0100582)1.75788527
82Abnormality of urine glucose concentration (HP:0011016)1.75776646
83Glycosuria (HP:0003076)1.75776646
84Rib fusion (HP:0000902)1.75684312
85Median cleft lip (HP:0000161)1.74407355
86Aganglionic megacolon (HP:0002251)1.73552001
87Degeneration of anterior horn cells (HP:0002398)1.73359273
88Abnormality of the anterior horn cell (HP:0006802)1.73359273
89Oculomotor apraxia (HP:0000657)1.72950581
90Broad foot (HP:0001769)1.72639880
91X-linked dominant inheritance (HP:0001423)1.71910516
92Respiratory difficulties (HP:0002880)1.70366852
93Absent septum pellucidum (HP:0001331)1.68909242
94Congenital, generalized hypertrichosis (HP:0004540)1.68198370
95Specific learning disability (HP:0001328)1.64861266
96Narrow forehead (HP:0000341)1.64539855
97Depressed nasal ridge (HP:0000457)1.63812708
98Abnormal biliary tract physiology (HP:0012439)1.59361094
99Bile duct proliferation (HP:0001408)1.59361094
100Methylmalonic acidemia (HP:0002912)1.58853189

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.81870382
2STK163.60988398
3WNK32.53647774
4TRIM282.46259899
5BCKDK2.38891312
6MAPK152.27183534
7BUB12.19938651
8DYRK22.14373985
9CDC72.04549469
10VRK12.02810992
11PNCK1.99917284
12NME11.98599778
13MST41.92592785
14DYRK31.83074017
15EPHB21.78010783
16BMPR1B1.75224954
17MAP3K121.73832723
18ZAK1.73058721
19MAP4K21.71249603
20SRPK11.66351730
21BCR1.65903203
22EPHA41.62958332
23MAP2K71.62761998
24PBK1.58154999
25CASK1.58032028
26TLK11.53225500
27WEE11.49529242
28PLK31.48233671
29NEK11.43591092
30MAP3K41.36670552
31CSNK1G21.31160921
32CSNK1G31.28907916
33NUAK11.25640476
34CDK191.22230076
35CSNK1G11.20252658
36NME21.14215644
37PLK21.12618993
38PLK11.12575948
39PLK41.10765301
40TAF11.08859516
41TTK1.03999218
42TNIK1.03301628
43MKNK11.01198536
44CDK81.01067735
45CSNK1A1L1.00866389
46GRK11.00399948
47BRSK20.98958903
48PINK10.98742919
49MARK10.92456817
50AURKA0.90915532
51BRSK10.90847655
52PASK0.90321039
53MINK10.90182965
54ADRBK20.90158328
55EIF2AK10.84912424
56PRKCG0.84109399
57LIMK10.81915219
58TSSK60.79890993
59ARAF0.78676812
60CHEK20.76997066
61MUSK0.76884536
62MKNK20.75561300
63PIM20.74610606
64AURKB0.70460165
65WNK40.68872043
66TGFBR10.68167528
67CCNB10.67029553
68ABL20.64950915
69ILK0.64493503
70ERBB30.61312610
71PAK30.61059733
72INSRR0.60161682
73MAPK130.57991581
74MAP2K40.57460980
75DAPK30.57374873
76CSNK2A20.57223852
77LRRK20.56596357
78MYLK0.56501775
79ATR0.55952198
80STK240.55013000
81CSNK2A10.54992622
82DYRK1A0.51948311
83BRAF0.49622834
84STK38L0.48767286
85PDK20.48382704
86EIF2AK30.47742013
87ADRBK10.47250580
88CSNK1E0.44687194
89RPS6KA50.44032531
90NTRK20.43864938
91PRKCE0.43813570
92EPHA20.42988287
93DYRK1B0.42301289
94OXSR10.42121921
95CSNK1A10.41230581
96CDK140.41153110
97PKN10.39989042
98NEK20.37906367
99PRKCI0.37707184
100CDK180.36767893

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.64598514
2Oxidative phosphorylation_Homo sapiens_hsa001904.63264250
3Parkinsons disease_Homo sapiens_hsa050124.01821939
4Huntingtons disease_Homo sapiens_hsa050163.29815281
5Proteasome_Homo sapiens_hsa030503.05470950
6Protein export_Homo sapiens_hsa030603.02093523
7Alzheimers disease_Homo sapiens_hsa050102.73253218
8RNA polymerase_Homo sapiens_hsa030202.50321304
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.18226713
10Mismatch repair_Homo sapiens_hsa034302.11001126
11Cardiac muscle contraction_Homo sapiens_hsa042602.10742868
12Homologous recombination_Homo sapiens_hsa034401.89312579
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.87616111
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.74004841
15DNA replication_Homo sapiens_hsa030301.64110237
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.61793006
17Steroid biosynthesis_Homo sapiens_hsa001001.52780868
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.46807878
19Glutathione metabolism_Homo sapiens_hsa004801.46783253
20Spliceosome_Homo sapiens_hsa030401.43932248
21Pyrimidine metabolism_Homo sapiens_hsa002401.40003048
22Fanconi anemia pathway_Homo sapiens_hsa034601.39209034
23Sulfur relay system_Homo sapiens_hsa041221.38055321
24Base excision repair_Homo sapiens_hsa034101.36775817
25Nucleotide excision repair_Homo sapiens_hsa034201.36534726
26Folate biosynthesis_Homo sapiens_hsa007901.34342058
27Basal transcription factors_Homo sapiens_hsa030221.30200675
28Fatty acid elongation_Homo sapiens_hsa000621.24111225
29Propanoate metabolism_Homo sapiens_hsa006401.23092431
30Basal cell carcinoma_Homo sapiens_hsa052171.20395705
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.19665070
32Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.17294132
33RNA degradation_Homo sapiens_hsa030181.16341733
34Purine metabolism_Homo sapiens_hsa002301.11321127
35Pyruvate metabolism_Homo sapiens_hsa006201.10638538
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.03508322
37Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.02010470
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.01907260
39RNA transport_Homo sapiens_hsa030131.00455386
40Phototransduction_Homo sapiens_hsa047440.99239019
41Hedgehog signaling pathway_Homo sapiens_hsa043400.98894109
42Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.96933811
43Non-homologous end-joining_Homo sapiens_hsa034500.95437660
44Peroxisome_Homo sapiens_hsa041460.94692778
45Collecting duct acid secretion_Homo sapiens_hsa049660.92596636
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.89895737
47Metabolic pathways_Homo sapiens_hsa011000.88310576
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.87810455
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.84824209
50Chemical carcinogenesis_Homo sapiens_hsa052040.84711509
51Butanoate metabolism_Homo sapiens_hsa006500.84672723
52Nicotine addiction_Homo sapiens_hsa050330.82527917
53Nitrogen metabolism_Homo sapiens_hsa009100.77569558
54One carbon pool by folate_Homo sapiens_hsa006700.75973962
552-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.72081419
56Biosynthesis of amino acids_Homo sapiens_hsa012300.65887216
57Cell cycle_Homo sapiens_hsa041100.62962931
58Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.61593630
59Arginine and proline metabolism_Homo sapiens_hsa003300.59968605
60Carbon metabolism_Homo sapiens_hsa012000.58740021
61Tyrosine metabolism_Homo sapiens_hsa003500.58107509
62Primary bile acid biosynthesis_Homo sapiens_hsa001200.57142646
63Hippo signaling pathway_Homo sapiens_hsa043900.56098861
64beta-Alanine metabolism_Homo sapiens_hsa004100.55624142
65Maturity onset diabetes of the young_Homo sapiens_hsa049500.52098412
66Sulfur metabolism_Homo sapiens_hsa009200.52093877
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49844560
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48800744
69Phenylalanine metabolism_Homo sapiens_hsa003600.47683784
70Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.46321946
71Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.45616202
72Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.45426139
73Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44509999
74p53 signaling pathway_Homo sapiens_hsa041150.43444986
75Alcoholism_Homo sapiens_hsa050340.42592970
76Tryptophan metabolism_Homo sapiens_hsa003800.42510946
77Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.42012896
78Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.41723654
79Wnt signaling pathway_Homo sapiens_hsa043100.40749588
80Caffeine metabolism_Homo sapiens_hsa002320.40685778
81Retinol metabolism_Homo sapiens_hsa008300.40070524
82Selenocompound metabolism_Homo sapiens_hsa004500.39131086
83Axon guidance_Homo sapiens_hsa043600.37450298
84Oocyte meiosis_Homo sapiens_hsa041140.37055944
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36730258
86N-Glycan biosynthesis_Homo sapiens_hsa005100.36222899
87Olfactory transduction_Homo sapiens_hsa047400.35276652
88Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.34704081
89Regulation of autophagy_Homo sapiens_hsa041400.34682801
90Linoleic acid metabolism_Homo sapiens_hsa005910.34626506
91Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.33908164
92Cocaine addiction_Homo sapiens_hsa050300.33592585
93Steroid hormone biosynthesis_Homo sapiens_hsa001400.31126953
94Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.30754231
95TGF-beta signaling pathway_Homo sapiens_hsa043500.29795032
96Taste transduction_Homo sapiens_hsa047420.29569816
97Vibrio cholerae infection_Homo sapiens_hsa051100.27261092
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.27080520
99Synaptic vesicle cycle_Homo sapiens_hsa047210.26362303
100Fatty acid degradation_Homo sapiens_hsa000710.25915216

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