DPCR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fibril organization (GO:0097435)9.54792075
2O-glycan processing (GO:0016266)8.64964982
3glutathione derivative metabolic process (GO:1901685)8.54327452
4glutathione derivative biosynthetic process (GO:1901687)8.54327452
5digestive system process (GO:0022600)8.41395644
6response to iron ion (GO:0010039)8.29748892
7sulfation (GO:0051923)7.98895737
8protein autoprocessing (GO:0016540)7.58703568
9terpenoid biosynthetic process (GO:0016114)7.17952379
10regulation of proton transport (GO:0010155)7.04367199
11intestinal cholesterol absorption (GO:0030299)6.81569115
12bundle of His cell to Purkinje myocyte communication (GO:0086069)6.76249877
13glandular epithelial cell differentiation (GO:0002067)6.65561329
14kidney morphogenesis (GO:0060993)6.59206034
153-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)6.49179622
16purine ribonucleoside bisphosphate metabolic process (GO:0034035)6.49179622
17negative regulation of digestive system process (GO:0060457)6.36010749
18protein O-linked glycosylation (GO:0006493)6.18300476
19hemidesmosome assembly (GO:0031581)6.09907244
20citrulline biosynthetic process (GO:0019240)5.94853583
21semaphorin-plexin signaling pathway (GO:0071526)5.82666618
22production of molecular mediator of immune response (GO:0002440)5.73657645
23negative regulation of transcription by competitive promoter binding (GO:0010944)5.73191501
24fucose catabolic process (GO:0019317)5.60805852
25L-fucose metabolic process (GO:0042354)5.60805852
26L-fucose catabolic process (GO:0042355)5.60805852
27positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003605.57461789
28regulation of phospholipase A2 activity (GO:0032429)5.54424771
29activation of Rac GTPase activity (GO:0032863)5.38635709
30thyroid hormone metabolic process (GO:0042403)5.17726828
31endothelial cell morphogenesis (GO:0001886)5.11495017
32cell-cell junction maintenance (GO:0045217)4.87853312
33thyroid hormone generation (GO:0006590)4.81163221
34phospholipid scrambling (GO:0017121)4.76243270
35phosphatidylserine acyl-chain remodeling (GO:0036150)4.70759497
36citrulline metabolic process (GO:0000052)4.67445639
37negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)4.61853923
38intestinal absorption (GO:0050892)4.61114506
39progesterone metabolic process (GO:0042448)4.46768763
40glutathione metabolic process (GO:0006749)4.35553510
41regulation of pH (GO:0006885)4.32983460
42negative regulation of protein tyrosine kinase activity (GO:0061099)4.23423903
43regulation of hydrogen peroxide metabolic process (GO:0010310)4.22610080
44leukotriene metabolic process (GO:0006691)4.21755367
45positive regulation of Cdc42 GTPase activity (GO:0043089)4.20219841
46cell junction maintenance (GO:0034331)4.12836163
47receptor recycling (GO:0001881)4.07248461
48pH reduction (GO:0045851)4.06303726
49lung secretory cell differentiation (GO:0061140)4.00800786
50germinal center formation (GO:0002467)3.99104366
51ventricular cardiac muscle cell action potential (GO:0086005)3.98362034
52negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.97953486
53phosphatidylserine metabolic process (GO:0006658)3.97712033
54glial cell proliferation (GO:0014009)3.93107132
55endosome organization (GO:0007032)3.92529389
56xenobiotic metabolic process (GO:0006805)3.90730707
57sulfur amino acid catabolic process (GO:0000098)3.90090071
58epithelial cell-cell adhesion (GO:0090136)3.82749822
59retinol metabolic process (GO:0042572)3.82484128
60acrosome reaction (GO:0007340)3.81956505
61thrombin receptor signaling pathway (GO:0070493)3.79743840
62leukotriene biosynthetic process (GO:0019370)3.77431305
63chondroitin sulfate catabolic process (GO:0030207)3.77056708
64regulation of ruffle assembly (GO:1900027)3.73163332
65peptidyl-tyrosine autophosphorylation (GO:0038083)3.70961340
66phosphatidylinositol acyl-chain remodeling (GO:0036149)3.70693352
67cyclooxygenase pathway (GO:0019371)3.69402982
68cellular response to gonadotropin stimulus (GO:0071371)3.65080954
69positive regulation of protein kinase C signaling (GO:0090037)3.64504920
70neutrophil mediated immunity (GO:0002446)3.62266768
71nitric oxide biosynthetic process (GO:0006809)3.60934764
72lung epithelium development (GO:0060428)3.58233752
73positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.54752561
74phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.54311443
75negative regulation of necroptotic process (GO:0060546)3.53093722
76cellular response to oxygen radical (GO:0071450)3.48440068
77removal of superoxide radicals (GO:0019430)3.48440068
78cellular response to superoxide (GO:0071451)3.48440068
79regulation of ARF GTPase activity (GO:0032312)3.45890077
80cell-substrate junction assembly (GO:0007044)3.42787570
81diacylglycerol metabolic process (GO:0046339)3.41996983
82endocytic recycling (GO:0032456)3.41133767
83columnar/cuboidal epithelial cell differentiation (GO:0002065)3.39192088
84phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.35043092
85retinoic acid metabolic process (GO:0042573)3.34919352
86regulation of Rho protein signal transduction (GO:0035023)3.33609675
87negative regulation of receptor activity (GO:2000272)3.31356334
88positive regulation of histone acetylation (GO:0035066)3.30934317
89regulation of heart rate by cardiac conduction (GO:0086091)3.28717497
90negative regulation of chondrocyte differentiation (GO:0032331)3.27677671
91alditol phosphate metabolic process (GO:0052646)3.27308545
92central nervous system myelination (GO:0022010)3.27135464
93axon ensheathment in central nervous system (GO:0032291)3.27135464
94Rho protein signal transduction (GO:0007266)3.27088562
95atrioventricular valve morphogenesis (GO:0003181)3.26537627
96fucose metabolic process (GO:0006004)3.25287301
97acid secretion (GO:0046717)3.24965894
98cell differentiation involved in embryonic placenta development (GO:0060706)3.22863322
99C21-steroid hormone metabolic process (GO:0008207)3.20939058
100cellular response to virus (GO:0098586)3.19918351
101negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.17996256
102cell volume homeostasis (GO:0006884)3.17901977
103sodium-independent organic anion transport (GO:0043252)3.16466741
104cobalamin metabolic process (GO:0009235)3.16356383
105positive regulation of Rac GTPase activity (GO:0032855)3.15566687
106regulation of necroptotic process (GO:0060544)3.14372107
107cholesterol catabolic process (GO:0006707)3.12550598
108sterol catabolic process (GO:0016127)3.12550598
109regulation of lamellipodium assembly (GO:0010591)3.11144829
110histone H4 deacetylation (GO:0070933)3.10459501
111peptidyl-arginine modification (GO:0018195)3.09261926
112branching involved in salivary gland morphogenesis (GO:0060445)3.09175799
113negative regulation of myotube differentiation (GO:0010832)3.08573235
114positive regulation of establishment of protein localization to plasma membrane (GO:0090004)3.07224523
115negative regulation of protein kinase B signaling (GO:0051898)3.06191800
116vascular endothelial growth factor signaling pathway (GO:0038084)3.06152072
117intestinal epithelial cell development (GO:0060576)3.04341738
118response to superoxide (GO:0000303)3.04091875
119fatty acid derivative transport (GO:1901571)3.02329573
120icosanoid transport (GO:0071715)3.02329573
121lung vasculature development (GO:0060426)3.00484209
122regulation of macrophage activation (GO:0043030)3.00210397
123regulation of cardioblast differentiation (GO:0051890)2.99634117
124L-serine transport (GO:0015825)2.98635844
125dermatan sulfate metabolic process (GO:0030205)2.98122077
126regulation of clathrin-mediated endocytosis (GO:2000369)2.97741878
127negative regulation of leukocyte chemotaxis (GO:0002689)2.96659055
128cellular response to arsenic-containing substance (GO:0071243)2.95702807
129bone remodeling (GO:0046849)2.94868302
130cardiac conduction (GO:0061337)2.94242362
131myelination in peripheral nervous system (GO:0022011)2.91667901
132peripheral nervous system axon ensheathment (GO:0032292)2.91667901
133positive regulation of protein localization to plasma membrane (GO:1903078)2.90700578
134arachidonic acid secretion (GO:0050482)2.90555126
135icosanoid secretion (GO:0032309)2.90555126
136myeloid leukocyte mediated immunity (GO:0002444)2.90008792
137protein retention in ER lumen (GO:0006621)2.89172542
138ribonucleoside bisphosphate metabolic process (GO:0033875)2.85853943
139nucleoside bisphosphate metabolic process (GO:0033865)2.85853943
140purine nucleoside bisphosphate metabolic process (GO:0034032)2.85853943
141synaptic transmission, cholinergic (GO:0007271)2.83822063
142renal filtration (GO:0097205)2.83372747
143regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.83267986
144monovalent inorganic cation homeostasis (GO:0055067)2.83067378
145ATP hydrolysis coupled proton transport (GO:0015991)2.82288961
146energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.82288961
147endothelial cell chemotaxis (GO:0035767)2.82121950
148regulation of cytokine production involved in inflammatory response (GO:1900015)2.80906243
149lung morphogenesis (GO:0060425)2.80782164
150mammary gland epithelial cell proliferation (GO:0033598)2.80439222
151response to oxygen radical (GO:0000305)2.79472211
152white fat cell differentiation (GO:0050872)2.78182671
153negative regulation of cell size (GO:0045792)2.77788959
154positive regulation of protein acetylation (GO:1901985)2.77746622
155positive regulation of peptidyl-lysine acetylation (GO:2000758)2.77746622
156negative regulation of osteoblast proliferation (GO:0033689)2.77378165
157regulation of interferon-beta biosynthetic process (GO:0045357)2.76376048
158positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.73882483
159myelin maintenance (GO:0043217)2.73787091
160ethanol oxidation (GO:0006069)2.73779655
161cell communication involved in cardiac conduction (GO:0086065)2.72860063
162nucleotide-sugar biosynthetic process (GO:0009226)2.71423882
163regulation of skeletal muscle contraction (GO:0014819)2.71215694
164negative regulation of necrotic cell death (GO:0060547)2.70969601
165activation of JUN kinase activity (GO:0007257)2.70037723
166morphogenesis of embryonic epithelium (GO:0016331)2.68873643
167filopodium assembly (GO:0046847)2.67896726
168fucosylation (GO:0036065)2.67372644
169maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.67223187
170response to gonadotropin (GO:0034698)2.67041900
171cell-substrate adherens junction assembly (GO:0007045)2.65866643
172focal adhesion assembly (GO:0048041)2.65866643
173hydrogen ion transmembrane transport (GO:1902600)2.65131662
174regulation of transforming growth factor beta1 production (GO:0032908)2.65110937
175desmosome organization (GO:0002934)2.64613759
176histone H3 deacetylation (GO:0070932)2.64458911
177growth hormone secretion (GO:0030252)2.63380032
178sodium ion export (GO:0071436)2.62706607
179ceramide catabolic process (GO:0046514)2.62537873
180cytoskeletal anchoring at plasma membrane (GO:0007016)2.61686810
181positive regulation of Rho GTPase activity (GO:0032321)2.61362768
182vitamin transport (GO:0051180)2.60431197
183serine transport (GO:0032329)2.59358574
184embryonic foregut morphogenesis (GO:0048617)2.57231457
185flavonoid metabolic process (GO:0009812)2.47721051
186maintenance of gastrointestinal epithelium (GO:0030277)19.5801011
187epithelial structure maintenance (GO:0010669)14.4988534
188digestion (GO:0007586)11.5415217
189extracellular fibril organization (GO:0043206)11.2199727
190diterpenoid biosynthetic process (GO:0016102)10.4369808

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_15608294_ChIP-ChIP_MCF-7_Human6.68774375
2* SOX2_27498859_Chip-Seq_STOMACH_Mouse5.23349090
3STAT6_21828071_ChIP-Seq_BEAS2B_Human3.94848677
4ESR1_21235772_ChIP-Seq_MCF-7_Human3.87949626
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.53883435
6ESR2_21235772_ChIP-Seq_MCF-7_Human3.45395714
7ZNF263_19887448_ChIP-Seq_K562_Human3.20419400
8GATA4_25053715_ChIP-Seq_YYC3_Human2.80241713
9ELK3_25401928_ChIP-Seq_HUVEC_Human2.68321409
10IGF1R_20145208_ChIP-Seq_DFB_Human2.67557235
11SOX2_20726797_ChIP-Seq_SW620_Human2.45535588
12THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.43753977
13VDR_22108803_ChIP-Seq_LS180_Human2.42456888
14ESR1_20079471_ChIP-ChIP_T-47D_Human2.33837384
15ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.32617926
16HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.30766853
17* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.24550003
18AHR_22903824_ChIP-Seq_MCF-7_Human2.21650875
19PPAR_26484153_Chip-Seq_NCI-H1993_Human2.18212800
20KDM2B_26808549_Chip-Seq_SUP-B15_Human2.08835131
21* TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.07059668
22EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.06648629
23TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.05140352
24HIF1A_21447827_ChIP-Seq_MCF-7_Human2.01348481
25FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.96253567
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.88080059
27P68_20966046_ChIP-Seq_HELA_Human1.86626276
28* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.84030930
29CDX2_20551321_ChIP-Seq_CACO-2_Human1.81712377
30RARG_19884340_ChIP-ChIP_MEFs_Mouse1.81256846
31CTCF_27219007_Chip-Seq_Bcells_Human1.80693899
32UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.78477775
33KLF5_25053715_ChIP-Seq_YYC3_Human1.75822944
34ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.70354838
35TRIM28_21343339_ChIP-Seq_HEK293_Human1.68946012
36ZNF217_24962896_ChIP-Seq_MCF-7_Human1.66077410
37DNAJC2_21179169_ChIP-ChIP_NT2_Human1.65118805
38SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.64715393
39ATF3_27146783_Chip-Seq_COLON_Human1.63675896
40* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.62784458
41* GATA6_25053715_ChIP-Seq_YYC3_Human1.62500776
42SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.59467525
43FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.59300489
44NR3C1_21868756_ChIP-Seq_MCF10A_Human1.58649267
45CDX2_19796622_ChIP-Seq_MESCs_Mouse1.58564174
46TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.58337055
47EP300_21415370_ChIP-Seq_HL-1_Mouse1.57466266
48* KDM2B_26808549_Chip-Seq_K562_Human1.57295068
49SA1_27219007_Chip-Seq_ERYTHROID_Human1.56917513
50ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.55945071
51EGR1_19032775_ChIP-ChIP_M12_Human1.55451945
52* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.53605237
53ARNT_22903824_ChIP-Seq_MCF-7_Human1.52764166
54PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.52107476
55SRY_22984422_ChIP-ChIP_TESTIS_Rat1.51199712
56TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50244647
57MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.48705208
58SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.47295515
59ERG_21242973_ChIP-ChIP_JURKAT_Human1.46519697
60TCF7_22412390_ChIP-Seq_EML_Mouse1.45232095
61AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.44606302
62CTCF_27219007_Chip-Seq_ERYTHROID_Human1.43761693
63SMC4_20622854_ChIP-Seq_HELA_Human1.41244139
64BCOR_27268052_Chip-Seq_Bcells_Human1.40594548
65KDM2B_26808549_Chip-Seq_DND41_Human1.40310632
66BCAT_22108803_ChIP-Seq_LS180_Human1.33818802
67SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.33603433
68IKZF1_21737484_ChIP-ChIP_HCT116_Human1.33331372
69BCL6_27268052_Chip-Seq_Bcells_Human1.31742511
70TP63_22573176_ChIP-Seq_HFKS_Human1.31344695
71NFIB_24661679_ChIP-Seq_LUNG_Mouse1.30647915
72* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.30462629
73JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.29855917
74VDR_21846776_ChIP-Seq_THP-1_Human1.29816073
75JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.29608068
76IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.29473563
77FOXM1_26456572_ChIP-Seq_MCF-7_Human1.27350663
78CREB1_26743006_Chip-Seq_LNCaP_Human1.26075441
79TET1_21451524_ChIP-Seq_MESCs_Mouse1.24848405
80CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.24202156
81SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.21649484
82SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.21649484
83RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.21164733
84E2F1_20622854_ChIP-Seq_HELA_Human1.19026701
85RXR_22108803_ChIP-Seq_LS180_Human1.18011522
86SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.17997227
87LXR_22158963_ChIP-Seq_LIVER_Mouse1.17745560
88P300_27058665_Chip-Seq_ZR-75-30cells_Human1.16816153
89PPARA_22158963_ChIP-Seq_LIVER_Mouse1.16158781
90ZFP281_18757296_ChIP-ChIP_E14_Mouse1.14185384
91KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.13644734
92SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.13078382
93* GATA3_24758297_ChIP-Seq_MCF-7_Human1.12945356
94ZNF274_21170338_ChIP-Seq_K562_Hela1.12279379
95FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.12238358
96ZFP281_27345836_Chip-Seq_ESCs_Mouse1.11804341
97RUNX1_27514584_Chip-Seq_MCF-7_Human1.11643062
98UBF1/2_26484160_Chip-Seq_HMECs_Human1.10434461
99PHF8_20622854_ChIP-Seq_HELA_Human1.10367566
100STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.09866804
101TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.09230854
102KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.09139520
103LXR_22292898_ChIP-Seq_THP-1_Human1.08137157
104ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07751121
105NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.06193961
106EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.05589043
107CTCF_20526341_ChIP-Seq_ESCs_Human1.05437476
108RARA_24833708_ChIP-Seq_LIVER_Mouse1.04965581
109* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.04944515
110CJUN_26792858_Chip-Seq_BT549_Human1.04765987
111SMC1_22415368_ChIP-Seq_MEFs_Mouse1.04648760
112FOXA2_19822575_ChIP-Seq_HepG2_Human1.03859471
113SMC3_22415368_ChIP-Seq_MEFs_Mouse1.02996035
114Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.02971301
115EZH2_27294783_Chip-Seq_ESCs_Mouse1.02121197
116TP53_22127205_ChIP-Seq_IMR90_Human1.01837744
117AR_21572438_ChIP-Seq_LNCaP_Human1.00861526
118ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.00595155
119EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.99850494
120RARB_24833708_ChIP-Seq_LIVER_Mouse0.99678401
121TCF4_18268006_ChIP-ChIP_LS174T_Human0.99579708
122GBX2_23144817_ChIP-Seq_PC3_Human0.99377321
123RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.99007234
124SMAD3_21741376_ChIP-Seq_EPCs_Human0.98197559
125TET1_21490601_ChIP-Seq_MESCs_Mouse0.97451166
126CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.97167778
127SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.96612279
128JARID2_20075857_ChIP-Seq_MESCs_Mouse0.96545367
129SA1_27219007_Chip-Seq_Bcells_Human0.96462107
130RAD21_21589869_ChIP-Seq_MESCs_Mouse0.96328728
131RXR_22158963_ChIP-Seq_LIVER_Mouse0.96308694
132RACK7_27058665_Chip-Seq_MCF-7_Human0.96156804
133P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.95170789
134RUNX1_22412390_ChIP-Seq_EML_Mouse0.94944465
135FOXO3_23340844_ChIP-Seq_DLD1_Human0.94797950
136JARID2_20064375_ChIP-Seq_MESCs_Mouse0.94779101
137MYC_19829295_ChIP-Seq_ESCs_Human0.94172396
138SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.93849810
139* STAT1_20625510_ChIP-Seq_HELA_Human0.93230415
140TP53_16413492_ChIP-PET_HCT116_Human0.92683427
141SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.90833330
142BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90334671
143NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.89855401
144NRF2_20460467_ChIP-Seq_MEFs_Mouse0.89855401
145MTF2_20144788_ChIP-Seq_MESCs_Mouse0.89592239
146SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.87286816
147GATA2_21666600_ChIP-Seq_HMVEC_Human0.86508691
148TP63_17297297_ChIP-ChIP_HaCaT_Human0.85841391
149HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.85706915
150EZH2_18974828_ChIP-Seq_MESCs_Mouse0.85415209
151RNF2_18974828_ChIP-Seq_MESCs_Mouse0.85415209
152DROSHA_22980978_ChIP-Seq_HELA_Human0.83795780
153CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.83314575
154SUZ12_27294783_Chip-Seq_ESCs_Mouse0.82626309
155BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.81862141
156RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.81531579
157PIAS1_25552417_ChIP-Seq_VCAP_Human0.81490630
158SALL4_18804426_ChIP-ChIP_XEN_Mouse0.81438893
159FOXA1_25552417_ChIP-Seq_VCAP_Human0.81335632
160SOX9_24532713_ChIP-Seq_HFSC_Mouse0.80523758
161KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.80036077
162KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.80036077

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001873_stomach_inflammation6.15066664
2MP0001664_abnormal_digestion5.23016287
3MP0000470_abnormal_stomach_morphology4.03259168
4MP0002933_joint_inflammation3.24575572
5MP0003806_abnormal_nucleotide_metabolis3.24463328
6MP0001663_abnormal_digestive_system2.18460781
7MP0001502_abnormal_circadian_rhythm2.14272480
8MP0001958_emphysema2.08916763
9MP0008004_abnormal_stomach_pH17.9015659
10MP0005023_abnormal_wound_healing1.99619943
11MP0005381_digestive/alimentary_phenotyp1.91053629
12MP0005670_abnormal_white_adipose1.85269750
13MP0004272_abnormal_basement_membrane1.77796054
14MP0002138_abnormal_hepatobiliary_system1.77378539
15MP0005165_increased_susceptibility_to1.69842733
16MP0003172_abnormal_lysosome_physiology1.67023741
17MP0004084_abnormal_cardiac_muscle1.61425942
18MP0001666_abnormal_nutrient_absorption1.59318757
19MP0005076_abnormal_cell_differentiation1.58603867
20MP0010368_abnormal_lymphatic_system1.54874293
21MP0005058_abnormal_lysosome_morphology1.54663331
22MP0005409_darkened_coat_color1.52888051
23MP0000751_myopathy1.51000998
24MP0002932_abnormal_joint_morphology1.50049596
25MP0002089_abnormal_postnatal_growth/wei1.48122193
26MP0004782_abnormal_surfactant_physiolog1.45602298
27MP0004883_abnormal_blood_vessel1.45463549
28MP0006138_congestive_heart_failure1.43514692
29MP0010234_abnormal_vibrissa_follicle1.42029540
30MP0000003_abnormal_adipose_tissue1.39542685
31MP0001348_abnormal_lacrimal_gland1.29981513
32MP0000858_altered_metastatic_potential1.28193893
33MP0005083_abnormal_biliary_tract1.22425462
34MP0005164_abnormal_response_to1.21280845
35MP0000767_abnormal_smooth_muscle1.20715599
36MP0005666_abnormal_adipose_tissue1.20101397
37MP0000477_abnormal_intestine_morphology1.19941775
38MP0002249_abnormal_larynx_morphology1.16223371
39MP0005375_adipose_tissue_phenotype1.12827002
40MP0003279_aneurysm1.12267518
41MP0003011_delayed_dark_adaptation1.11388916
42MP0010030_abnormal_orbit_morphology1.11292754
43MP0004264_abnormal_extraembryonic_tissu1.09585061
44MP0003186_abnormal_redox_activity1.01544771
45MP0005595_abnormal_vascular_smooth0.99838530
46MP0000163_abnormal_cartilage_morphology0.94730153
47MP0002282_abnormal_trachea_morphology0.90908108
48MP0003283_abnormal_digestive_organ0.89872215
49MP0000462_abnormal_digestive_system0.89751287
50MP0002909_abnormal_adrenal_gland0.89105862
51MP0003091_abnormal_cell_migration0.87806556
52MP0001188_hyperpigmentation0.87691646
53MP0005508_abnormal_skeleton_morphology0.86874329
54MP0005085_abnormal_gallbladder_physiolo0.82115052
55MP0006054_spinal_hemorrhage0.81915077
56MP0009384_cardiac_valve_regurgitation0.81091369
57MP0002998_abnormal_bone_remodeling0.78692201
58MP0000490_abnormal_crypts_of0.78176836
59MP0009053_abnormal_anal_canal0.76730472
60MP0009840_abnormal_foam_cell0.75547479
61MP0000249_abnormal_blood_vessel0.73640364
62MP0000678_abnormal_parathyroid_gland0.73427205
63MP0003868_abnormal_feces_composition0.70081922
64MP0002419_abnormal_innate_immunity0.66860912
65MP0002136_abnormal_kidney_physiology0.66740462
66MP0000537_abnormal_urethra_morphology0.66472255
67MP0002925_abnormal_cardiovascular_devel0.65722634
68MP0003828_pulmonary_edema0.64145936
69MP0003959_abnormal_lean_body0.63036268
70MP0000467_abnormal_esophagus_morphology0.62547311
71MP0002113_abnormal_skeleton_development0.62401499
72MP0005636_abnormal_mineral_homeostasis0.62232418
73MP0004484_altered_response_of0.62120297
74MP0005266_abnormal_metabolism0.61715764
75MP0004036_abnormal_muscle_relaxation0.60863626
76MP0008961_abnormal_basal_metabolism0.60440639
77MP0005365_abnormal_bile_salt0.59300216
78MP0001879_abnormal_lymphatic_vessel0.58921464
79MP0003115_abnormal_respiratory_system0.58803636
80MP0001614_abnormal_blood_vessel0.58469666
81MP0003795_abnormal_bone_structure0.57938268
82MP0006072_abnormal_retinal_apoptosis0.57142334
83MP0002896_abnormal_bone_mineralization0.56382611
84MP0004858_abnormal_nervous_system0.56379448
85MP0005390_skeleton_phenotype0.55164021
86MP0002234_abnormal_pharynx_morphology0.54985078
87MP0010155_abnormal_intestine_physiology0.52760605
88MP0008875_abnormal_xenobiotic_pharmacok0.50304887
89MP0003705_abnormal_hypodermis_morpholog0.48746946
90MP0010329_abnormal_lipoprotein_level0.47795914
91MP0002009_preneoplasia0.46903401
92MP0009780_abnormal_chondrocyte_physiolo0.46397593
93MP0003075_altered_response_to0.44790585
94MP0004185_abnormal_adipocyte_glucose0.44481329
95MP0002796_impaired_skin_barrier0.39717880
96MP0001243_abnormal_dermal_layer0.39375485
97MP0003953_abnormal_hormone_level0.38425132
98MP0002693_abnormal_pancreas_physiology0.36379194
99MP0003724_increased_susceptibility_to0.35998497
100MP0002877_abnormal_melanocyte_morpholog0.33303669
101MP0002078_abnormal_glucose_homeostasis0.31597721
102MP0002118_abnormal_lipid_homeostasis0.31464032
103MP0004947_skin_inflammation0.30873762
104MP0010678_abnormal_skin_adnexa0.30871311
105MP0002019_abnormal_tumor_incidence0.30363450
106MP0003866_abnormal_defecation0.30051396
107MP0005166_decreased_susceptibility_to0.29275490
108MP0001216_abnormal_epidermal_layer0.28863814
109MP0003252_abnormal_bile_duct0.28333184
110MP0001845_abnormal_inflammatory_respons0.27689941
111MP0008873_increased_physiological_sensi0.27266279
112MP0003119_abnormal_digestive_system0.27246302
113MP0000566_synostosis0.25788786
114MP0003566_abnormal_cell_adhesion0.25535118
115MP0002060_abnormal_skin_morphology0.24864645
116MP0005310_abnormal_salivary_gland0.24776686
117MP0001440_abnormal_grooming_behavior0.23446665
118MP0000367_abnormal_coat/_hair0.23276443
119MP0005408_hypopigmentation0.22899219
120MP0003638_abnormal_response/metabolism_0.22106902
121MP0009642_abnormal_blood_homeostasis0.21060100
122MP0005584_abnormal_enzyme/coenzyme_acti0.20215088
123MP0005367_renal/urinary_system_phenotyp0.20136606
124MP0000516_abnormal_urinary_system0.20136606
125MP0005376_homeostasis/metabolism_phenot0.19927428
126MP0002970_abnormal_white_adipose0.19861035
127MP0004859_abnormal_synaptic_plasticity0.18631067
128MP0003941_abnormal_skin_development0.17951625
129MP0005501_abnormal_skin_physiology0.17921705
130MP0003690_abnormal_glial_cell0.17772380
131MP0004043_abnormal_pH_regulation0.17467020
132MP0002139_abnormal_hepatobiliary_system0.17330423
133MP0003453_abnormal_keratinocyte_physiol0.16850346
134MP0010771_integument_phenotype0.15883083
135MP0000762_abnormal_tongue_morphology0.15660632
136MP0000465_gastrointestinal_hemorrhage0.14997208
137MP0002733_abnormal_thermal_nociception0.14829357
138MP0005452_abnormal_adipose_tissue0.14363412
139MP0002098_abnormal_vibrissa_morphology0.14071979
140MP0002277_abnormal_respiratory_mucosa0.12830976
141MP0001191_abnormal_skin_condition0.12644664
142MP0000613_abnormal_salivary_gland0.12314970
143MP0000609_abnormal_liver_physiology0.12245787
144MP0000598_abnormal_liver_morphology0.12214788
145MP0001849_ear_inflammation0.12113187
146MP0005319_abnormal_enzyme/_coenzyme0.11879614
147MP0005464_abnormal_platelet_physiology0.11531088
148MP0003329_amyloid_beta_deposits0.11332037
149MP0004019_abnormal_vitamin_homeostasis0.10988704
150MP0009931_abnormal_skin_appearance0.10777928
151MP0003045_fibrosis0.10543463
152MP0003191_abnormal_cellular_cholesterol0.09746818
153MP0005248_abnormal_Harderian_gland0.09154545
154MP0000920_abnormal_myelination0.08922229
155MP0000013_abnormal_adipose_tissue0.08805532
156MP0002736_abnormal_nociception_after0.08526304

Predicted human phenotypes

RankGene SetZ-score
1Thin bony cortex (HP:0002753)7.15349944
2Broad metatarsal (HP:0001783)7.01530107
3Abnormality of the vitamin B12 metabolism (HP:0004341)5.88477500
4Megaloblastic anemia (HP:0001889)5.70449488
5Abnormality of vitamin B metabolism (HP:0004340)5.50192410
6Broad face (HP:0000283)5.49245787
7J-shaped sella turcica (HP:0002680)5.14013616
8Syncope (HP:0001279)4.79678853
9Abnormality of vitamin metabolism (HP:0100508)4.78733669
10Goiter (HP:0000853)4.75085215
11Upper limb amyotrophy (HP:0009129)4.74202503
12Distal upper limb amyotrophy (HP:0007149)4.74202503
13Palpitations (HP:0001962)4.68947373
14Shallow orbits (HP:0000586)4.51910755
15Distal lower limb amyotrophy (HP:0008944)4.42440315
16Cervical subluxation (HP:0003308)4.41478630
17Woolly hair (HP:0002224)4.38733543
18Obstructive sleep apnea (HP:0002870)4.26935385
19Gout (HP:0001997)4.25158476
20Joint stiffness (HP:0001387)4.12941740
21Spinal canal stenosis (HP:0003416)4.09405648
22Severe Myopia (HP:0011003)3.84525455
23Aortic valve stenosis (HP:0001650)3.63082412
24Lymphangioma (HP:0100764)3.58383729
25Abnormality of purine metabolism (HP:0004352)3.53856022
26Ventricular fibrillation (HP:0001663)3.46158390
27Bronchomalacia (HP:0002780)3.44748832
28Lower limb amyotrophy (HP:0007210)3.44252837
29Arterial tortuosity (HP:0005116)3.37036131
30Mitral regurgitation (HP:0001653)3.35251717
31Hyperactive renin-angiotensin system (HP:0000841)3.33187089
32Intrahepatic cholestasis (HP:0001406)3.27016680
33Frequent falls (HP:0002359)3.14812780
34Glomerulosclerosis (HP:0000096)3.12382524
35Tubulointerstitial nephritis (HP:0001970)3.10642601
36Ventricular arrhythmia (HP:0004308)3.09188817
37Conjugated hyperbilirubinemia (HP:0002908)3.03475805
38Cerebral palsy (HP:0100021)3.01178103
39Vascular tortuosity (HP:0004948)2.91963305
40Hemiplegia (HP:0002301)2.83986360
41Ventricular tachycardia (HP:0004756)2.82883844
42Back pain (HP:0003418)2.78007101
43Stridor (HP:0010307)2.75609502
44Diaphragmatic weakness (HP:0009113)2.70320312
45Hyperuricemia (HP:0002149)2.68477238
46Increased purine levels (HP:0004368)2.68477238
47Vascular calcification (HP:0004934)2.67454260
48Wrist flexion contracture (HP:0001239)2.64952831
49Agitation (HP:0000713)2.64622121
50Aplasia/Hypoplasia of the clavicles (HP:0006710)2.62194532
51Curly hair (HP:0002212)2.61683334
52Broad ribs (HP:0000885)2.61511190
53Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)2.59628348
54Aortic dissection (HP:0002647)2.58731041
55Deformed sella turcica (HP:0002681)2.56421539
56Protrusio acetabuli (HP:0003179)2.56323645
57Abnormality of the gastric mucosa (HP:0004295)2.54882265
58Generalized hypopigmentation of hair (HP:0011358)2.53931548
59Mucopolysacchariduria (HP:0008155)2.53522511
60Urinary glycosaminoglycan excretion (HP:0003541)2.53522511
61Broad palm (HP:0001169)2.53090307
62Pterygium (HP:0001059)2.51976394
63Hemorrhage of the eye (HP:0011885)2.50278551
64Abnormality of polysaccharide metabolism (HP:0011012)2.46830698
65Abnormality of glycosaminoglycan metabolism (HP:0004371)2.46830698
66Abnormality of mucopolysaccharide metabolism (HP:0011020)2.46830698
67Flat acetabular roof (HP:0003180)2.44043320
68Cerebral aneurysm (HP:0004944)2.42351231
69Round ear (HP:0100830)2.41764505
70Oligodontia (HP:0000677)2.41576034
71Neonatal death (HP:0003811)2.41046851
72Cardiovascular calcification (HP:0011915)2.40649645
73Micronodular cirrhosis (HP:0001413)2.38628266
74Stage 5 chronic kidney disease (HP:0003774)2.38467842
75Atrophic scars (HP:0001075)2.37485606
76Axonal loss (HP:0003447)2.34829771
77Infantile muscular hypotonia (HP:0008947)2.34706797
78Coxa vara (HP:0002812)2.34169253
79Abnormality of the anterior chamber (HP:0000593)2.31872127
80Down-sloping shoulders (HP:0200021)2.31043142
81Vertebral arch anomaly (HP:0008438)2.29022541
82Renal cortical cysts (HP:0000803)2.24309726
83Onycholysis (HP:0001806)2.22982567
84Thickened helices (HP:0000391)2.22273963
85Renal salt wasting (HP:0000127)2.20029910
86Abnormality of the renal cortex (HP:0011035)2.19651007
87Hand muscle atrophy (HP:0009130)2.15167213
88Sudden cardiac death (HP:0001645)2.14775256
89Abnormal cortical bone morphology (HP:0003103)2.14122322
90Tubulointerstitial fibrosis (HP:0005576)2.13508278
91Sensorimotor neuropathy (HP:0007141)2.12772973
92Interstitial pulmonary disease (HP:0006530)2.12742794
93Selective tooth agenesis (HP:0001592)2.11422632
94Abnormal vertebral ossification (HP:0100569)2.10322798
95Focal segmental glomerulosclerosis (HP:0000097)2.09018178
96Thoracic kyphosis (HP:0002942)2.08788224
97Hypoplasia of dental enamel (HP:0006297)2.07949523
98Premature loss of primary teeth (HP:0006323)2.07691446
99Rectal prolapse (HP:0002035)2.05795703
100Pustule (HP:0200039)2.05590552
101Coronal craniosynostosis (HP:0004440)2.05033121
102Abnormality of monocarboxylic acid metabolism (HP:0010996)2.02491986
103Paresthesia (HP:0003401)2.02336944
104Skull defect (HP:0001362)2.01281762
105Abnormality of the thoracic spine (HP:0100711)2.01089646
106Neurodegeneration (HP:0002180)2.00508106
107Abnormal number of erythroid precursors (HP:0012131)11.5667424
108Right ventricular cardiomyopathy (HP:0011663)10.9519044
109Abnormality of cells of the erythroid lineage (HP:0012130)10.1847816
110Abnormality of nucleobase metabolism (HP:0010932)1.97765099
111Macroglossia (HP:0000158)1.97557574
112Lumbar hyperlordosis (HP:0002938)1.97458272
113Cupped ribs (HP:0000887)1.96941151
114Hypoplastic left heart (HP:0004383)1.94209568
115Onion bulb formation (HP:0003383)1.93903195
116Choroideremia (HP:0001139)1.93498823
117Seborrheic dermatitis (HP:0001051)1.93282740
118Alopecia of scalp (HP:0002293)1.93189039
119Fragile nails (HP:0001808)1.91748458
120Short clavicles (HP:0000894)1.91065001
121Long palpebral fissure (HP:0000637)1.88620933
122Cone-rod dystrophy (HP:0000548)1.87796057
123Milia (HP:0001056)1.87185073
124Congenital, generalized hypertrichosis (HP:0004540)1.86300043
125Tubular atrophy (HP:0000092)1.85373280
126Abnormality of the 1st metacarpal (HP:0010009)1.85221570
127Plantar hyperkeratosis (HP:0007556)1.83734038
128Increased variability in muscle fiber diameter (HP:0003557)1.83486793
129Abnormal cartilage morphology (HP:0002763)1.82947429
130Restlessness (HP:0000711)1.81108931
131Abdominal distention (HP:0003270)1.77380655
132Testicular neoplasm (HP:0010788)1.76419940
133Lethargy (HP:0001254)1.75077883
134Neoplasm of the heart (HP:0100544)1.74780071
135Ketoacidosis (HP:0001993)1.74438498
136Ankyloglossia (HP:0010296)1.73478002
137Esophageal varix (HP:0002040)1.73213442
138Spinal muscular atrophy (HP:0007269)1.73158883
139Aplasia/hypoplasia of the femur (HP:0005613)1.72838912
140Distal lower limb muscle weakness (HP:0009053)1.72277576
141Coxa valga (HP:0002673)1.71814884
142Bone pain (HP:0002653)1.69842955
143Growth hormone excess (HP:0000845)1.67901859
144Nuclear cataract (HP:0100018)1.67635638
145Hyperkalemia (HP:0002153)1.67543081
146Periodontitis (HP:0000704)1.67417532
147Abnormality of renin-angiotensin system (HP:0000847)1.66355509
148Emphysema (HP:0002097)1.65947232
149Aortic aneurysm (HP:0004942)1.65019574
150Prolonged QT interval (HP:0001657)1.64804248
151Symphalangism affecting the phalanges of the hand (HP:0009773)1.64669587
152Deep venous thrombosis (HP:0002625)1.64132325
153Lower limb hyperreflexia (HP:0002395)1.63657514
154Abnormality of skeletal muscle fiber size (HP:0012084)1.62284798
155Pulmonary artery stenosis (HP:0004415)1.62031294
156Pili torti (HP:0003777)1.61886632
157Fragile skin (HP:0001030)1.61269760
158Spastic tetraparesis (HP:0001285)1.60008946
159Macrocytic anemia (HP:0001972)1.59248861
160Abnormal tarsal ossification (HP:0008369)1.58216238
161Spinal rigidity (HP:0003306)1.58065362
162Aneurysm (HP:0002617)1.54110846
163Xerostomia (HP:0000217)1.51609260
164Microretrognathia (HP:0000308)1.51008962
165Ectopia lentis (HP:0001083)1.50296451
166Aortic regurgitation (HP:0001659)1.49763809
167Hyperglycemia (HP:0003074)1.49064144
168Germ cell neoplasia (HP:0100728)1.48965393
169Toxemia of pregnancy (HP:0100603)1.47202231
170Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.47037194
171Vertebral hypoplasia (HP:0008417)1.47037194
172Ketosis (HP:0001946)1.46792391
173Mildly elevated creatine phosphokinase (HP:0008180)1.44463577
174Abnormality of carpal bone ossification (HP:0006257)1.44235058

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA26.33183798
2MST44.77408138
3MST1R4.11478444
4MAP3K62.17319749
5ERBB414.0311423
6SIK11.79859277
7RIPK41.77940740
8MET1.55293725
9MARK21.53811226
10TNK21.53481940
11PIK3CG1.44157027
12MAP3K71.41966650
13PDGFRA1.36038941
14NUAK11.34965856
15PKN21.32150427
16LRRK21.30910647
17TRIB31.27432121
18MAP3K91.22639595
19MAP4K11.21751212
20SIK31.20956597
21KSR21.16545678
22MAP3K21.13253557
23FER1.13243341
24MAP2K11.08816388
25STK101.08730858
26MAP2K21.05021207
27MUSK1.03058180
28MYLK0.99087224
29TBK10.96608157
30PRKD20.95569681
31PTK2B0.89975548
32STK390.88686125
33PAK30.87830459
34PRKG20.87556057
35FYN0.87064753
36PRKCI0.86482748
37BCKDK0.84520182
38LMTK20.83103732
39FLT30.79454134
40PTK60.75081293
41WNK40.73356433
42NTRK10.73096329
43NME10.72806381
44FRK0.70791856
45PDGFRB0.68376865
46CASK0.67468549
47DDR20.67257943
48ROCK20.66473645
49IRAK30.65652699
50KDR0.65486129
51RPS6KC10.61230612
52RPS6KL10.61230612
53TAOK10.56359577
54CDK80.55107812
55RPS6KA60.54254638
56RIPK10.53768049
57TESK10.53160388
58MATK0.50482490
59SRC0.49141496
60PRPF4B0.46487001
61FGFR40.43833913
62ZAP700.42945934
63CHUK0.41823068
64IKBKE0.41570819
65RPS6KA20.41461213
66CAMK2B0.41389358
67PDK40.39963999
68PDK30.39963999
69PTK20.39509899
70ICK0.38395519
71FGR0.38319649
72ROCK10.38150114
73SIK20.36688178
74CSK0.35344543
75PDPK10.35286712
76MAP3K110.34758686
77ERBB20.34581054
78MAP3K80.33950134
79CDK90.33706138
80CAMK2D0.32520548
81BMX0.32074484
82DMPK0.32047424
83PHKG10.31225839
84MAP2K30.31065373
85TGFBR20.30621587
86LATS10.30154533
87NTRK30.29466952
88ERN10.28004070
89OXSR10.27884779
90CAMK2G0.27593125
91JAK30.27374099
92MAP3K30.27174322
93ZAK0.26857068
94NEK10.25946592
95RPS6KA40.25937638
96MAPK70.25693698
97PDK20.25609613
98MAP3K130.25543212
99PIK3CA0.25031677
100CDK190.24816437
101IGF1R0.24309862
102PRKCQ0.24262156
103MTOR0.24196644
104CSF1R0.23545620
105PAK40.23405740
106NEK90.23148288
107PDK10.22967540
108HIPK20.22952986
109DAPK20.22544300
110BRAF0.22423729
111MINK10.22250329
112ABL20.22216151
113RET0.21713580
114EPHA40.21571533
115STK380.21408245
116MAPK80.21319513
117MAP3K10.21296463
118ARAF0.21288861
119EPHB10.20822079
120LIMK10.20775921
121YES10.20617702
122TAOK20.19875833
123PRKAA20.19859284
124IKBKB0.19138461
125BTK0.18454892
126EEF2K0.17585997
127MAP2K60.17315352
128GRK60.16927772
129EGFR0.16612966
130RPS6KB20.16339439
131PRKD10.16126489
132PKN10.15570099
133CAMK2A0.15457821
134ADRBK10.15363143
135MAP3K140.14874796
136CDK50.14510398
137PRKCE0.14319502
138CDC42BPA0.13923733
139GRK10.13503501
140KSR10.13019448
141PRKD30.12523766
142EPHB20.12183704
143PRKCH0.11815863
144CAMKK10.11807297
145WNK10.11713073
146PIM20.11037548
147NME20.11031914
148PHKG20.10910291

Predicted pathways (KEGG)

RankGene SetZ-score
1Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009805.41015115
2Gastric acid secretion_Homo sapiens_hsa049715.00738080
3Sulfur metabolism_Homo sapiens_hsa009204.71684245
4Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005124.52580563
5Collecting duct acid secretion_Homo sapiens_hsa049664.48816471
6Drug metabolism - cytochrome P450_Homo sapiens_hsa009824.31638801
7Chemical carcinogenesis_Homo sapiens_hsa052043.75782705
8Notch signaling pathway_Homo sapiens_hsa043303.41494949
9Glutathione metabolism_Homo sapiens_hsa004803.38333737
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.27620960
11Glycosaminoglycan degradation_Homo sapiens_hsa005313.08987169
12Other glycan degradation_Homo sapiens_hsa005112.77993107
13Cyanoamino acid metabolism_Homo sapiens_hsa004602.73714099
14Fat digestion and absorption_Homo sapiens_hsa049752.24943751
15Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.22330565
16ECM-receptor interaction_Homo sapiens_hsa045122.05213445
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.04894298
18Vitamin digestion and absorption_Homo sapiens_hsa049771.96329833
19Linoleic acid metabolism_Homo sapiens_hsa005911.80577869
20Ether lipid metabolism_Homo sapiens_hsa005651.57907474
21Mineral absorption_Homo sapiens_hsa049781.55059478
22Chronic myeloid leukemia_Homo sapiens_hsa052201.51766427
23VEGF signaling pathway_Homo sapiens_hsa043701.47957532
24Focal adhesion_Homo sapiens_hsa045101.43866169
25Pancreatic secretion_Homo sapiens_hsa049721.41686793
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.39016299
27Phospholipase D signaling pathway_Homo sapiens_hsa040721.29058456
28Dilated cardiomyopathy_Homo sapiens_hsa054141.27960721
29Retinol metabolism_Homo sapiens_hsa008301.25686263
30Circadian rhythm_Homo sapiens_hsa047101.20614084
31Protein digestion and absorption_Homo sapiens_hsa049741.19466445
32Inositol phosphate metabolism_Homo sapiens_hsa005621.07829975
33RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.05179674
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.04289339
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02840714
36Choline metabolism in cancer_Homo sapiens_hsa052311.01045961
37Thyroid hormone synthesis_Homo sapiens_hsa049181.00610925
38AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.98619183
39Small cell lung cancer_Homo sapiens_hsa052220.98203203
40Rap1 signaling pathway_Homo sapiens_hsa040150.97945306
41Fatty acid degradation_Homo sapiens_hsa000710.93818782
42Longevity regulating pathway - mammal_Homo sapiens_hsa042110.91577527
43Steroid hormone biosynthesis_Homo sapiens_hsa001400.90887605
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.89855217
45Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.89143149
46Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.88925831
47Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87932710
48Aldosterone synthesis and secretion_Homo sapiens_hsa049250.87509366
49Complement and coagulation cascades_Homo sapiens_hsa046100.86510514
50Hepatitis C_Homo sapiens_hsa051600.85939500
51Oxidative phosphorylation_Homo sapiens_hsa001900.84679529
52Toxoplasmosis_Homo sapiens_hsa051450.84122198
53Thyroid hormone signaling pathway_Homo sapiens_hsa049190.83946876
54TNF signaling pathway_Homo sapiens_hsa046680.81698595
55Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.80443260
56Propanoate metabolism_Homo sapiens_hsa006400.78154437
572-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.77700744
58Ovarian steroidogenesis_Homo sapiens_hsa049130.77469133
59mTOR signaling pathway_Homo sapiens_hsa041500.77049657
60ErbB signaling pathway_Homo sapiens_hsa040120.76942615
61Prolactin signaling pathway_Homo sapiens_hsa049170.75099831
62Glycerolipid metabolism_Homo sapiens_hsa005610.74746808
63Sulfur relay system_Homo sapiens_hsa041220.72110184
64Galactose metabolism_Homo sapiens_hsa000520.71961679
65beta-Alanine metabolism_Homo sapiens_hsa004100.71359109
66Arachidonic acid metabolism_Homo sapiens_hsa005900.71006857
67Phenylalanine metabolism_Homo sapiens_hsa003600.70039212
68Starch and sucrose metabolism_Homo sapiens_hsa005000.69776254
69Histidine metabolism_Homo sapiens_hsa003400.69528828
70Insulin signaling pathway_Homo sapiens_hsa049100.68407114
71Ras signaling pathway_Homo sapiens_hsa040140.68321426
72Endocytosis_Homo sapiens_hsa041440.67740080
73Pancreatic cancer_Homo sapiens_hsa052120.67731089
74Pyruvate metabolism_Homo sapiens_hsa006200.67690706
75MAPK signaling pathway_Homo sapiens_hsa040100.65306445
76Bile secretion_Homo sapiens_hsa049760.64807443
77Acute myeloid leukemia_Homo sapiens_hsa052210.64672743
78Bladder cancer_Homo sapiens_hsa052190.64665909
79Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64231164
80Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63992445
81Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.62134076
82Insulin resistance_Homo sapiens_hsa049310.61421692
83Vascular smooth muscle contraction_Homo sapiens_hsa042700.60929965
84Amoebiasis_Homo sapiens_hsa051460.59834799
85Nitrogen metabolism_Homo sapiens_hsa009100.59287447
86Butanoate metabolism_Homo sapiens_hsa006500.58641321
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.56620817
88Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55223839
89Tight junction_Homo sapiens_hsa045300.53889876
90Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.53250698
91Maturity onset diabetes of the young_Homo sapiens_hsa049500.53080202
92Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.52959013
93Central carbon metabolism in cancer_Homo sapiens_hsa052300.52797528
94Platelet activation_Homo sapiens_hsa046110.51269274
95Influenza A_Homo sapiens_hsa051640.50782709
96Pertussis_Homo sapiens_hsa051330.50762794
97PI3K-Akt signaling pathway_Homo sapiens_hsa041510.49899284
98Pathways in cancer_Homo sapiens_hsa052000.48268161
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47585796
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46319621
101Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.45023031
102Neurotrophin signaling pathway_Homo sapiens_hsa047220.44267787
103Lysine degradation_Homo sapiens_hsa003100.43533488
104Regulation of autophagy_Homo sapiens_hsa041400.43201827
105Salivary secretion_Homo sapiens_hsa049700.43070016
106Renal cell carcinoma_Homo sapiens_hsa052110.40982370
107Toll-like receptor signaling pathway_Homo sapiens_hsa046200.39343243
108Carbon metabolism_Homo sapiens_hsa012000.39316982
109Fatty acid metabolism_Homo sapiens_hsa012120.38321126
110Lysosome_Homo sapiens_hsa041420.36725341
111Dorso-ventral axis formation_Homo sapiens_hsa043200.36589497
112Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35378355
113Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.35321112
114Tyrosine metabolism_Homo sapiens_hsa003500.31435324
115Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.29239767
116PPAR signaling pathway_Homo sapiens_hsa033200.28555210
117Tryptophan metabolism_Homo sapiens_hsa003800.26260459
118Leukocyte transendothelial migration_Homo sapiens_hsa046700.25776335
119Sphingolipid metabolism_Homo sapiens_hsa006000.25391085
120Insulin secretion_Homo sapiens_hsa049110.24891783
121Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.24088780
122ABC transporters_Homo sapiens_hsa020100.23666081
123Thyroid cancer_Homo sapiens_hsa052160.22290327
124Vibrio cholerae infection_Homo sapiens_hsa051100.22209280
125Fatty acid elongation_Homo sapiens_hsa000620.21231676
126Salmonella infection_Homo sapiens_hsa051320.21159062
127Fructose and mannose metabolism_Homo sapiens_hsa000510.20796726
128Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.20092640
129Taste transduction_Homo sapiens_hsa047420.19552802
130Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.18487042
131Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.18394593
132Adherens junction_Homo sapiens_hsa045200.16452906
133Cardiac muscle contraction_Homo sapiens_hsa042600.16380776
134cGMP-PKG signaling pathway_Homo sapiens_hsa040220.15935803
135Cholinergic synapse_Homo sapiens_hsa047250.15393208
136Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.15074856
137Arginine biosynthesis_Homo sapiens_hsa002200.14668547
138Long-term depression_Homo sapiens_hsa047300.14158748
139Pentose phosphate pathway_Homo sapiens_hsa000300.13975444
140Long-term potentiation_Homo sapiens_hsa047200.13429155
141GnRH signaling pathway_Homo sapiens_hsa049120.13175789
142Renin secretion_Homo sapiens_hsa049240.11338937
143Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.11311910
144Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.10870529
145GABAergic synapse_Homo sapiens_hsa047270.10782349
146Glutamatergic synapse_Homo sapiens_hsa047240.10696137
147Shigellosis_Homo sapiens_hsa051310.10095260
148Metabolic pathways_Homo sapiens_hsa011000.10078727
149Circadian entrainment_Homo sapiens_hsa047130.09900239
150Axon guidance_Homo sapiens_hsa043600.09878363
151Peroxisome_Homo sapiens_hsa041460.09815564
152Regulation of actin cytoskeleton_Homo sapiens_hsa048100.09104115
153Estrogen signaling pathway_Homo sapiens_hsa049150.08726496
154Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.08313941
155Alzheimers disease_Homo sapiens_hsa050100.08152465
156Morphine addiction_Homo sapiens_hsa050320.06917386
157Proteoglycans in cancer_Homo sapiens_hsa052050.06613802
158cAMP signaling pathway_Homo sapiens_hsa040240.05907629
159Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.03774175

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