DPF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the d4 domain family, characterized by a zinc finger-like structural motif. This protein functions as a transcription factor which is necessary for the apoptotic response following deprivation of survival factors. It likely serves a regulatory role in rapid hematopoietic cell growth and turnover. This gene is considered a candidate gene for multiple endocrine neoplasia type I, an inherited cancer syndrome involving multiple parathyroid, enteropancreatic, and pituitary tumors. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)4.45013895
2RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.42880701
3tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.42880701
4DNA strand elongation (GO:0022616)4.26931398
5telomere maintenance via semi-conservative replication (GO:0032201)4.10319627
6ribosomal small subunit assembly (GO:0000028)4.06819731
7DNA unwinding involved in DNA replication (GO:0006268)3.91555528
8DNA replication checkpoint (GO:0000076)3.82772720
9piRNA metabolic process (GO:0034587)3.80189129
10neural tube formation (GO:0001841)3.80014470
11DNA replication initiation (GO:0006270)3.77612544
12protein-cofactor linkage (GO:0018065)3.71458808
13telomere maintenance via recombination (GO:0000722)3.69828377
14nucleobase biosynthetic process (GO:0046112)3.69107662
15somatic hypermutation of immunoglobulin genes (GO:0016446)3.68074975
16somatic diversification of immune receptors via somatic mutation (GO:0002566)3.68074975
17IMP biosynthetic process (GO:0006188)3.66160114
18DNA methylation involved in gamete generation (GO:0043046)3.65044227
19formation of translation preinitiation complex (GO:0001731)3.63427030
20maturation of SSU-rRNA (GO:0030490)3.60393662
21protein localization to kinetochore (GO:0034501)3.56075742
22DNA deamination (GO:0045006)3.52688404
23negative regulation of telomere maintenance (GO:0032205)3.52319294
24mitotic nuclear envelope disassembly (GO:0007077)3.50461454
25purine nucleobase biosynthetic process (GO:0009113)3.48429407
26mitochondrial RNA metabolic process (GO:0000959)3.47232940
27mitotic recombination (GO:0006312)3.46515688
28protein complex biogenesis (GO:0070271)3.40446276
29respiratory chain complex IV assembly (GO:0008535)3.39825518
30cytochrome complex assembly (GO:0017004)3.33305971
31base-excision repair, AP site formation (GO:0006285)3.32660467
32preassembly of GPI anchor in ER membrane (GO:0016254)3.31219160
33mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.29684470
34mitochondrial respiratory chain complex I assembly (GO:0032981)3.29684470
35NADH dehydrogenase complex assembly (GO:0010257)3.29684470
36negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.28480322
37mitotic metaphase plate congression (GO:0007080)3.28331955
38metallo-sulfur cluster assembly (GO:0031163)3.27249941
39iron-sulfur cluster assembly (GO:0016226)3.27249941
40telomere maintenance via telomere lengthening (GO:0010833)3.26622810
41mitochondrial respiratory chain complex assembly (GO:0033108)3.26380168
42regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.24444306
43histone H4-K12 acetylation (GO:0043983)3.24100318
44histone H2A acetylation (GO:0043968)3.22911714
45DNA alkylation (GO:0006305)3.22756936
46DNA methylation (GO:0006306)3.22756936
47nuclear envelope disassembly (GO:0051081)3.20334041
48membrane disassembly (GO:0030397)3.20334041
49DNA modification (GO:0006304)3.18429199
50behavioral response to nicotine (GO:0035095)3.18338987
51DNA methylation or demethylation (GO:0044728)3.17430446
52mannosylation (GO:0097502)3.14941593
53nucleotide-excision repair, DNA gap filling (GO:0006297)3.13882666
54IMP metabolic process (GO:0046040)3.12400338
55histone arginine methylation (GO:0034969)3.12135708
56ubiquinone biosynthetic process (GO:0006744)3.12014214
57spliceosomal snRNP assembly (GO:0000387)3.09566653
58tRNA modification (GO:0006400)3.08187671
59protein localization to chromosome, centromeric region (GO:0071459)3.07644073
60ribosome biogenesis (GO:0042254)3.07622803
61negative regulation of RNA splicing (GO:0033119)3.07511273
62negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.04464970
63RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.02235030
64mRNA splicing, via spliceosome (GO:0000398)3.02235030
65meiotic chromosome segregation (GO:0045132)3.02074099
66RNA splicing, via transesterification reactions (GO:0000375)3.00560381
67viral transcription (GO:0019083)2.99451457
68reciprocal DNA recombination (GO:0035825)2.96035541
69reciprocal meiotic recombination (GO:0007131)2.96035541
70DNA integration (GO:0015074)2.94278878
71L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.93763086
72ribosomal large subunit biogenesis (GO:0042273)2.92600274
73translational termination (GO:0006415)2.92426038
74histone H3-K9 methylation (GO:0051567)2.92370996
75viral mRNA export from host cell nucleus (GO:0046784)2.92167753
76kynurenine metabolic process (GO:0070189)2.92060958
77metaphase plate congression (GO:0051310)2.91767360
78peptidyl-arginine methylation (GO:0018216)2.91423272
79peptidyl-arginine N-methylation (GO:0035246)2.91423272
80tRNA processing (GO:0008033)2.89875434
81ribonucleoprotein complex biogenesis (GO:0022613)2.88280860
82transcription-coupled nucleotide-excision repair (GO:0006283)2.87046181
83ubiquinone metabolic process (GO:0006743)2.86902002
84histone H4-K8 acetylation (GO:0043982)2.85438579
85histone H4-K5 acetylation (GO:0043981)2.85438579
86regulation of spindle organization (GO:0090224)2.85377841
87negative regulation of DNA-dependent DNA replication (GO:2000104)2.84910106
88CENP-A containing nucleosome assembly (GO:0034080)2.84321263
89maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.83244223
90platelet dense granule organization (GO:0060155)2.83080132
91DNA demethylation (GO:0080111)2.83001833
92translational initiation (GO:0006413)2.82918987
93protein polyglutamylation (GO:0018095)2.81665479
94spliceosomal complex assembly (GO:0000245)2.81389069
95translational elongation (GO:0006414)2.81011561
96snRNA processing (GO:0016180)2.80965650
97maturation of 5.8S rRNA (GO:0000460)2.80175473
98deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.80073586
99aggressive behavior (GO:0002118)2.79564741
100rRNA catabolic process (GO:0016075)2.79291994
101regulation of meiosis I (GO:0060631)2.78135522
102indolalkylamine catabolic process (GO:0046218)2.77650044
103tryptophan catabolic process (GO:0006569)2.77650044
104indole-containing compound catabolic process (GO:0042436)2.77650044
105mitotic spindle assembly checkpoint (GO:0007094)2.76992395
106seminiferous tubule development (GO:0072520)2.76767742
107DNA replication-independent nucleosome organization (GO:0034724)2.76492608
108DNA replication-independent nucleosome assembly (GO:0006336)2.76492608
109negative regulation of chromosome segregation (GO:0051985)2.76310196
110pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.75909617
111spindle assembly checkpoint (GO:0071173)2.75626115
112regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.75388431
113negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.74839131
114negative regulation of sister chromatid segregation (GO:0033046)2.74839131
115negative regulation of mitotic sister chromatid separation (GO:2000816)2.74839131
116negative regulation of mitotic sister chromatid segregation (GO:0033048)2.74839131
117DNA duplex unwinding (GO:0032508)2.74627903
118attachment of spindle microtubules to kinetochore (GO:0008608)2.74283348
119proteasome assembly (GO:0043248)2.73843894
120snRNA metabolic process (GO:0016073)2.73797882
121anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.73433669
122kinetochore organization (GO:0051383)2.72767454
123DNA geometric change (GO:0032392)2.72666035
124fucose catabolic process (GO:0019317)2.71907957
125L-fucose metabolic process (GO:0042354)2.71907957
126L-fucose catabolic process (GO:0042355)2.71907957
127GMP metabolic process (GO:0046037)2.71082138
128nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.70382093
129telomere organization (GO:0032200)2.70287012
130regulation of nuclear cell cycle DNA replication (GO:0033262)2.70274070
131mitotic sister chromatid segregation (GO:0000070)2.70097962
132chromatin remodeling at centromere (GO:0031055)2.69548987
133negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.69508094
134telomere maintenance (GO:0000723)2.68996479
135establishment of chromosome localization (GO:0051303)2.68907981
136regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.68590250
137DNA replication-dependent nucleosome assembly (GO:0006335)2.67638870
138DNA replication-dependent nucleosome organization (GO:0034723)2.67638870
139kinetochore assembly (GO:0051382)2.67477526
140termination of RNA polymerase II transcription (GO:0006369)2.67202757
141negative regulation of mRNA processing (GO:0050686)2.65366355
142mismatch repair (GO:0006298)2.64807680
143negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.63936620
144transcription elongation from RNA polymerase III promoter (GO:0006385)2.63711180
145termination of RNA polymerase III transcription (GO:0006386)2.63711180
146rRNA processing (GO:0006364)2.62793477
147nuclear pore organization (GO:0006999)2.62618028
148positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.62581100
149base-excision repair (GO:0006284)2.62206042
150pseudouridine synthesis (GO:0001522)2.62152120
151nuclear envelope organization (GO:0006998)2.61870580
152gene silencing by RNA (GO:0031047)2.61084324
153anterograde synaptic vesicle transport (GO:0048490)2.60943236
154ATP-dependent chromatin remodeling (GO:0043044)2.60168170
155postreplication repair (GO:0006301)2.60162234
156RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.59982267
157positive regulation of chromosome segregation (GO:0051984)2.59960831
158negative regulation of DNA-templated transcription, elongation (GO:0032785)2.59434574
159mitotic spindle checkpoint (GO:0071174)2.58428197
160folic acid-containing compound biosynthetic process (GO:0009396)2.58321600
161SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.57369932
162intra-S DNA damage checkpoint (GO:0031573)2.57368059
163spindle checkpoint (GO:0031577)2.57306733
164regulation of histone H3-K4 methylation (GO:0051569)2.56024591
165cellular biogenic amine catabolic process (GO:0042402)2.55521267
166amine catabolic process (GO:0009310)2.55521267
167DNA-templated transcription, termination (GO:0006353)2.55470738
168GPI anchor metabolic process (GO:0006505)2.55436037
169regulation of mitotic metaphase/anaphase transition (GO:0030071)2.55386767
170peptidyl-arginine omega-N-methylation (GO:0035247)2.54758257
171indolalkylamine metabolic process (GO:0006586)2.54595204
172regulation of double-strand break repair via homologous recombination (GO:0010569)2.54319829
173multicellular organism reproduction (GO:0032504)2.52653084
174tRNA metabolic process (GO:0006399)2.52415174
175DNA catabolic process, exonucleolytic (GO:0000738)2.51499045
176gonadal mesoderm development (GO:0007506)2.51463826
177synapsis (GO:0007129)2.49152446
178positive regulation of histone H3-K4 methylation (GO:0051571)2.48630992
179protein-DNA complex disassembly (GO:0032986)2.48553923
180nucleosome disassembly (GO:0006337)2.48553923
181RNA modification (GO:0009451)2.46647883
182adenosine metabolic process (GO:0046085)2.45583467
183replication fork processing (GO:0031297)2.44021823
184adaptation of signaling pathway (GO:0023058)2.43149764
185negative regulation of B cell apoptotic process (GO:0002903)2.40044663
186recombinational repair (GO:0000725)2.38796280
187nonmotile primary cilium assembly (GO:0035058)2.38299758
188peptidyl-histidine modification (GO:0018202)2.38216729
189cullin deneddylation (GO:0010388)2.37336282
190C-terminal protein amino acid modification (GO:0018410)2.37206148

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.56201098
2ZNF274_21170338_ChIP-Seq_K562_Hela4.17794574
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.60498085
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.47326484
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.42738307
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.05575517
7EZH2_22144423_ChIP-Seq_EOC_Human2.93067063
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.85491096
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.76512931
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.62947212
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.62384578
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.62088612
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.61210419
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.48607494
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.47748352
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.47063763
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.45716281
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.45127788
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.45098727
20CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.43831125
21MYC_19030024_ChIP-ChIP_MESCs_Mouse2.42168468
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.33509509
23XRN2_22483619_ChIP-Seq_HELA_Human2.31427736
24CIITA_25753668_ChIP-Seq_RAJI_Human2.29180803
25MYC_22102868_ChIP-Seq_BL_Human2.26331673
26IRF1_19129219_ChIP-ChIP_H3396_Human2.15464615
27VDR_23849224_ChIP-Seq_CD4+_Human2.13045340
28SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.08371795
29* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.03820697
30FOXP3_21729870_ChIP-Seq_TREG_Human2.00057751
31THAP11_20581084_ChIP-Seq_MESCs_Mouse1.98236486
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.97007303
33MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.93147355
34* GABP_19822575_ChIP-Seq_HepG2_Human1.88995911
35TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.88337231
36* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.84349915
37NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.75769459
38E2F1_21310950_ChIP-Seq_MCF-7_Human1.74882389
39SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.74364139
40DCP1A_22483619_ChIP-Seq_HELA_Human1.73210420
41CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.71888127
42* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.71617625
43* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.71602876
44TTF2_22483619_ChIP-Seq_HELA_Human1.68551780
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68495029
46* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.68236490
47VDR_22108803_ChIP-Seq_LS180_Human1.68143039
48FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.65134316
49CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.63516347
50FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.63264578
51ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.62858440
52* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.62516857
53VDR_21846776_ChIP-Seq_THP-1_Human1.62449881
54SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.62084566
55TP53_22573176_ChIP-Seq_HFKS_Human1.61381242
56TP63_19390658_ChIP-ChIP_HaCaT_Human1.60213863
57SALL1_21062744_ChIP-ChIP_HESCs_Human1.60135178
58SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.59974640
59MYCN_18555785_ChIP-Seq_MESCs_Mouse1.59351852
60POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.59306089
61YY1_21170310_ChIP-Seq_MESCs_Mouse1.58394258
62HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.58283073
63MYC_18940864_ChIP-ChIP_HL60_Human1.56858737
64NANOG_18555785_ChIP-Seq_MESCs_Mouse1.52642855
65CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.51348585
66KDM5A_27292631_Chip-Seq_BREAST_Human1.49350317
67ERG_20887958_ChIP-Seq_HPC-7_Mouse1.44118205
68SRF_21415370_ChIP-Seq_HL-1_Mouse1.41222627
69ZFX_18555785_ChIP-Seq_MESCs_Mouse1.41217160
70AR_21909140_ChIP-Seq_LNCAP_Human1.40307399
71TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.39487430
72* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.39344694
73IGF1R_20145208_ChIP-Seq_DFB_Human1.39119185
74TFEB_21752829_ChIP-Seq_HELA_Human1.34937766
75ELK1_19687146_ChIP-ChIP_HELA_Human1.34293602
76EWS_26573619_Chip-Seq_HEK293_Human1.33269826
77SPI1_23547873_ChIP-Seq_NB4_Human1.32576567
78IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.31437598
79* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.29946647
80CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.29723953
81SCL_19346495_ChIP-Seq_HPC-7_Human1.28795296
82* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.28267919
83GBX2_23144817_ChIP-Seq_PC3_Human1.26773466
84ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.26331407
85NOTCH1_21737748_ChIP-Seq_TLL_Human1.24595672
86CTBP2_25329375_ChIP-Seq_LNCAP_Human1.24593435
87CTBP1_25329375_ChIP-Seq_LNCAP_Human1.21083315
88FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19727060
89RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.17058944
90DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.17034724
91* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.16913286
92GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.15596089
93* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.15145918
94CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.14980011
95PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.12092779
96YY1_22570637_ChIP-Seq_MALME-3M_Human1.11469313
97TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08934086
98KLF4_18555785_ChIP-Seq_MESCs_Mouse1.08380159
99UTX_26944678_Chip-Seq_JUKART_Human1.08209698
100ERA_21632823_ChIP-Seq_H3396_Human1.07968084
101* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.06827135
102MAF_26560356_Chip-Seq_TH1_Human1.06809365
103* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.05993726
104E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.01786989
105ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.01041836
106* PKCTHETA_26484144_Chip-Seq_BREAST_Human1.00836187
107SOX2_16153702_ChIP-ChIP_HESCs_Human0.99940391
108CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.99901251
109HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.99152479
110* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.98299780
111LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.97691503
112CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.97216932
113MYB_26560356_Chip-Seq_TH2_Human0.96549795
114* REST_21632747_ChIP-Seq_MESCs_Mouse0.96020870
115OCT4_20526341_ChIP-Seq_ESCs_Human0.95417929
116KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.94871914
117MYB_26560356_Chip-Seq_TH1_Human0.93459760
118GATA3_21878914_ChIP-Seq_MCF-7_Human0.93126889
119MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.92786793
120SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.92613212
121SOX2_18555785_ChIP-Seq_MESCs_Mouse0.91908958
122E2F1_17053090_ChIP-ChIP_MCF-7_Human0.91830926
123NANOG_21062744_ChIP-ChIP_HESCs_Human0.91809066
124* NANOG_20526341_ChIP-Seq_ESCs_Human0.91717843
125FUS_26573619_Chip-Seq_HEK293_Human0.91471566
126RUNX1_22412390_ChIP-Seq_EML_Mouse0.91318478
127MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.91229648
128* FOXP1_21924763_ChIP-Seq_HESCs_Human0.90620020
129PADI4_21655091_ChIP-ChIP_MCF-7_Human0.90524287
130* P300_27268052_Chip-Seq_Bcells_Human0.90159870
131RAC3_21632823_ChIP-Seq_H3396_Human0.89200990
132POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.89071442
133* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.88922672
134MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.88546736
135* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.88341835
136HOXB7_26014856_ChIP-Seq_BT474_Human0.88209501
137* PHF8_20622854_ChIP-Seq_HELA_Human0.88133765
138SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.87335327
139POU5F1_16153702_ChIP-ChIP_HESCs_Human0.87244673
140IRF8_22096565_ChIP-ChIP_GC-B_Human0.86687268
141MYB_21317192_ChIP-Seq_ERMYB_Mouse0.86239199
142KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.85570336
143MAF_26560356_Chip-Seq_TH2_Human0.85361255
144NCOR_22424771_ChIP-Seq_293T_Human0.84284976
145GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.83696469
146VDR_24763502_ChIP-Seq_THP-1_Human0.83636120

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.64616657
2MP0003111_abnormal_nucleus_morphology3.78729233
3MP0010094_abnormal_chromosome_stability3.77299875
4MP0003077_abnormal_cell_cycle3.44273501
5MP0004957_abnormal_blastocyst_morpholog3.42692653
6MP0008057_abnormal_DNA_replication3.19598229
7MP0002396_abnormal_hematopoietic_system3.06529523
8MP0008058_abnormal_DNA_repair3.00992134
9MP0008007_abnormal_cellular_replicative2.73856735
10MP0003718_maternal_effect2.35587042
11MP0008995_early_reproductive_senescence2.34341262
12MP0004808_abnormal_hematopoietic_stem2.23044543
13MP0008932_abnormal_embryonic_tissue2.21000424
14MP0000566_synostosis2.07495553
15MP0002102_abnormal_ear_morphology2.03200691
16MP0003763_abnormal_thymus_physiology2.02252964
17MP0005645_abnormal_hypothalamus_physiol1.99113834
18MP0006072_abnormal_retinal_apoptosis1.96687738
19MP0003136_yellow_coat_color1.96330135
20MP0000350_abnormal_cell_proliferation1.89886258
21MP0001730_embryonic_growth_arrest1.89041446
22MP0000490_abnormal_crypts_of1.87185303
23MP0009333_abnormal_splenocyte_physiolog1.86686261
24MP0003787_abnormal_imprinting1.86324440
25MP0005551_abnormal_eye_electrophysiolog1.85540597
26MP0004133_heterotaxia1.83768792
27MP0005646_abnormal_pituitary_gland1.83091840
28MP0009046_muscle_twitch1.75098624
29MP0010352_gastrointestinal_tract_polyps1.74820131
30MP0003123_paternal_imprinting1.73012911
31MP0005671_abnormal_response_to1.72999008
32MP0001968_abnormal_touch/_nociception1.72732285
33MP0001986_abnormal_taste_sensitivity1.71277231
34MP0005397_hematopoietic_system_phenotyp1.70938530
35MP0001545_abnormal_hematopoietic_system1.70938530
36MP0002398_abnormal_bone_marrow1.68976259
37MP0006276_abnormal_autonomic_nervous1.67548351
38MP0003786_premature_aging1.66757212
39MP0008877_abnormal_DNA_methylation1.65738040
40MP0002638_abnormal_pupillary_reflex1.63711327
41MP0005253_abnormal_eye_physiology1.61911531
42MP0000703_abnormal_thymus_morphology1.59779866
43MP0003567_abnormal_fetal_cardiomyocyte1.57741840
44MP0002736_abnormal_nociception_after1.55927149
45MP0004147_increased_porphyrin_level1.53726008
46MP0009278_abnormal_bone_marrow1.53224108
47MP0000631_abnormal_neuroendocrine_gland1.51881777
48MP0001697_abnormal_embryo_size1.51880213
49MP0000313_abnormal_cell_death1.50382328
50MP0005394_taste/olfaction_phenotype1.49372865
51MP0005499_abnormal_olfactory_system1.49372865
52MP0002722_abnormal_immune_system1.48040779
53MP0001672_abnormal_embryogenesis/_devel1.47900682
54MP0005380_embryogenesis_phenotype1.47900682
55MP0008872_abnormal_physiological_respon1.47129520
56MP0001835_abnormal_antigen_presentation1.45454509
57MP0002735_abnormal_chemical_nociception1.44993606
58MP0002080_prenatal_lethality1.42915312
59MP0003984_embryonic_growth_retardation1.41587227
60MP0002019_abnormal_tumor_incidence1.41507777
61MP0001529_abnormal_vocalization1.40765918
62MP0006035_abnormal_mitochondrial_morpho1.40572647
63MP0000689_abnormal_spleen_morphology1.39215911
64MP0002088_abnormal_embryonic_growth/wei1.38878944
65MP0005075_abnormal_melanosome_morpholog1.32697414
66MP0000372_irregular_coat_pigmentation1.30142710
67MP0001293_anophthalmia1.28564830
68MP0002429_abnormal_blood_cell1.27796205
69MP0002085_abnormal_embryonic_tissue1.27685370
70MP0010307_abnormal_tumor_latency1.27410173
71MP0003119_abnormal_digestive_system1.26832048
72MP0002234_abnormal_pharynx_morphology1.26245657
73MP0000716_abnormal_immune_system1.25780654
74MP0002653_abnormal_ependyma_morphology1.24357363
75MP0003646_muscle_fatigue1.24038941
76MP0000685_abnormal_immune_system1.23517462
77MP0003880_abnormal_central_pattern1.19299977
78MP0006292_abnormal_olfactory_placode1.17975946
79MP0002733_abnormal_thermal_nociception1.17646082
80MP0006054_spinal_hemorrhage1.17051764
81MP0002420_abnormal_adaptive_immunity1.15610046
82MP0004142_abnormal_muscle_tone1.14653576
83MP0003698_abnormal_male_reproductive1.14650177
84MP0003121_genomic_imprinting1.14589725
85MP0001819_abnormal_immune_cell1.14542696
86MP0001800_abnormal_humoral_immune1.13634344
87MP0002086_abnormal_extraembryonic_tissu1.13633465
88MP0004197_abnormal_fetal_growth/weight/1.13373234
89MP0005367_renal/urinary_system_phenotyp1.13181260
90MP0000516_abnormal_urinary_system1.13181260
91MP0002084_abnormal_developmental_patter1.10036481
92MP0005076_abnormal_cell_differentiation1.09834980
93MP0002452_abnormal_antigen_presenting1.09055750
94MP0005174_abnormal_tail_pigmentation1.08226897
95MP0000653_abnormal_sex_gland1.05749332
96MP0006036_abnormal_mitochondrial_physio1.05624547
97MP0002723_abnormal_immune_serum1.05485314
98MP0002572_abnormal_emotion/affect_behav1.03176475
99MP0000465_gastrointestinal_hemorrhage1.02403325
100MP0009785_altered_susceptibility_to1.02025708
101MP0003221_abnormal_cardiomyocyte_apopto1.01891080
102MP0000858_altered_metastatic_potential1.00268134
103MP0001984_abnormal_olfaction0.99943283
104MP0005083_abnormal_biliary_tract0.98579744
105MP0002751_abnormal_autonomic_nervous0.97022655
106MP0008260_abnormal_autophagy0.96943082
107MP0002557_abnormal_social/conspecific_i0.96780828
108MP0002163_abnormal_gland_morphology0.95473535
109MP0002938_white_spotting0.94819750
110MP0002405_respiratory_system_inflammati0.93647607
111MP0004145_abnormal_muscle_electrophysio0.93160418
112MP0001905_abnormal_dopamine_level0.92627957
113MP0005410_abnormal_fertilization0.92264785
114MP0001970_abnormal_pain_threshold0.91533397
115MP0009745_abnormal_behavioral_response0.91455057
116MP0002210_abnormal_sex_determination0.91365478
117MP0001764_abnormal_homeostasis0.90719901
118MP0002132_abnormal_respiratory_system0.90615089
119MP0002272_abnormal_nervous_system0.90323117
120MP0005000_abnormal_immune_tolerance0.89557934
121MP0005025_abnormal_response_to0.88213304
122MP0004043_abnormal_pH_regulation0.86640065
123MP0003943_abnormal_hepatobiliary_system0.84707913
124MP0002138_abnormal_hepatobiliary_system0.83748952
125MP0005670_abnormal_white_adipose0.83321738
126MP0001873_stomach_inflammation0.83294147
127MP0010155_abnormal_intestine_physiology0.82937758
128MP0001119_abnormal_female_reproductive0.82495451
129MP0004084_abnormal_cardiac_muscle0.81741275
130MP0005464_abnormal_platelet_physiology0.81405482
131MP0003122_maternal_imprinting0.80662501
132MP0002095_abnormal_skin_pigmentation0.79426573
133MP0000428_abnormal_craniofacial_morphol0.78443691
134MP0001502_abnormal_circadian_rhythm0.77625527
135MP0000358_abnormal_cell_content/0.77518748
136MP0002254_reproductive_system_inflammat0.77387229
137MP0001145_abnormal_male_reproductive0.76543734
138MP0001853_heart_inflammation0.76348613
139MP0003315_abnormal_perineum_morphology0.76301070
140MP0003866_abnormal_defecation0.75571163
141MP0005384_cellular_phenotype0.75191221
142MP0009672_abnormal_birth_weight0.74581258
143MP0005391_vision/eye_phenotype0.74578171
144MP0001915_intracranial_hemorrhage0.74180057
145MP0003635_abnormal_synaptic_transmissio0.73684835
146MP0000613_abnormal_salivary_gland0.72973637
147MP0005621_abnormal_cell_physiology0.72472163
148MP0003828_pulmonary_edema0.72152963
149MP0002161_abnormal_fertility/fecundity0.71942658
150MP0001486_abnormal_startle_reflex0.71468248
151MP0010030_abnormal_orbit_morphology0.70819590
152MP0000049_abnormal_middle_ear0.70724818
153MP0005084_abnormal_gallbladder_morpholo0.69955419
154MP0002148_abnormal_hypersensitivity_rea0.69517909
155MP0002064_seizures0.68391364
156MP0002752_abnormal_somatic_nervous0.68311508
157MP0002693_abnormal_pancreas_physiology0.68300540
158MP0009697_abnormal_copulation0.66962388
159MP0009703_decreased_birth_body0.66835809
160MP0005387_immune_system_phenotype0.65806963
161MP0001790_abnormal_immune_system0.65806963
162MP0000015_abnormal_ear_pigmentation0.61819794
163MP0003448_altered_tumor_morphology0.61578087
164MP0008789_abnormal_olfactory_epithelium0.61499767
165MP0001929_abnormal_gametogenesis0.59887595
166MP0002925_abnormal_cardiovascular_devel0.59573146
167MP0000477_abnormal_intestine_morphology0.59403023
168MP0003566_abnormal_cell_adhesion0.59198316

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.10508354
2Aplastic anemia (HP:0001915)4.04382942
3Birth length less than 3rd percentile (HP:0003561)3.98542611
4Pancreatic fibrosis (HP:0100732)3.74181982
5True hermaphroditism (HP:0010459)3.62944128
6Molar tooth sign on MRI (HP:0002419)3.60755526
7Abnormality of midbrain morphology (HP:0002418)3.60755526
8Bile duct proliferation (HP:0001408)3.54170190
9Abnormal biliary tract physiology (HP:0012439)3.54170190
10Degeneration of anterior horn cells (HP:0002398)3.39326544
11Abnormality of the anterior horn cell (HP:0006802)3.39326544
12Reticulocytopenia (HP:0001896)3.30400330
13Nephronophthisis (HP:0000090)3.19860888
14Patellar aplasia (HP:0006443)3.19381277
15Congenital stationary night blindness (HP:0007642)3.04898535
16Cerebral hypomyelination (HP:0006808)3.04762129
17Aplasia/Hypoplasia of the patella (HP:0006498)3.00510590
18Petechiae (HP:0000967)2.97278660
19Chromosomal breakage induced by crosslinking agents (HP:0003221)2.95427344
20Attenuation of retinal blood vessels (HP:0007843)2.93045914
21Chromsome breakage (HP:0040012)2.89509028
22Myelodysplasia (HP:0002863)2.89482347
23Medial flaring of the eyebrow (HP:0010747)2.83320037
24Progressive inability to walk (HP:0002505)2.81888764
25Abnormality of the labia minora (HP:0012880)2.81541793
26Selective tooth agenesis (HP:0001592)2.81338053
27Medulloblastoma (HP:0002885)2.81219671
28Abnormality of the fingertips (HP:0001211)2.77882748
29Thrombocytosis (HP:0001894)2.77801629
30Cystic liver disease (HP:0006706)2.68136080
31Colon cancer (HP:0003003)2.66164682
32Abnormal number of erythroid precursors (HP:0012131)2.65006662
33Meckel diverticulum (HP:0002245)2.62509162
34Abnormality of the ileum (HP:0001549)2.59297014
35Increased nuchal translucency (HP:0010880)2.53672007
36Breast hypoplasia (HP:0003187)2.52426836
37Bone marrow hypocellularity (HP:0005528)2.52315081
38Abnormality of cells of the erythroid lineage (HP:0012130)2.52208686
39Muscle fiber atrophy (HP:0100295)2.51282041
40Nephrogenic diabetes insipidus (HP:0009806)2.50836805
41Rough bone trabeculation (HP:0100670)2.49086691
42Gait imbalance (HP:0002141)2.48626757
43IgM deficiency (HP:0002850)2.46512358
44Oral leukoplakia (HP:0002745)2.45741154
45Abnormality of the renal medulla (HP:0100957)2.43859228
46Congenital primary aphakia (HP:0007707)2.41249835
47Sclerocornea (HP:0000647)2.39595112
48Acute lymphatic leukemia (HP:0006721)2.36666298
49Chronic hepatic failure (HP:0100626)2.34199812
50Amaurosis fugax (HP:0100576)2.34053782
51Methylmalonic aciduria (HP:0012120)2.33409379
52Lissencephaly (HP:0001339)2.32753146
53Type I transferrin isoform profile (HP:0003642)2.32468076
54Abnormality of the preputium (HP:0100587)2.30811768
55Genetic anticipation (HP:0003743)2.28664813
56Abnormality of chromosome stability (HP:0003220)2.27107800
57Aplasia/Hypoplasia of the uvula (HP:0010293)2.26999628
58Premature graying of hair (HP:0002216)2.26267271
59Type 2 muscle fiber atrophy (HP:0003554)2.25457201
60Abnormal protein glycosylation (HP:0012346)2.25227868
61Abnormal glycosylation (HP:0012345)2.25227868
62Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.25227868
63Abnormal protein N-linked glycosylation (HP:0012347)2.25227868
64Optic nerve coloboma (HP:0000588)2.24733307
65Anencephaly (HP:0002323)2.24259424
66Lymphoma (HP:0002665)2.23609904
67Inability to walk (HP:0002540)2.22794657
68Preaxial hand polydactyly (HP:0001177)2.22443351
69Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.22380382
70Abnormality of alanine metabolism (HP:0010916)2.22380382
71Hyperalaninemia (HP:0003348)2.22380382
72Ependymoma (HP:0002888)2.21482599
73Aplasia/Hypoplasia of the tongue (HP:0010295)2.20085135
743-Methylglutaconic aciduria (HP:0003535)2.19867472
75Retinal dysplasia (HP:0007973)2.18661756
76Postaxial foot polydactyly (HP:0001830)2.17003565
77Abolished electroretinogram (ERG) (HP:0000550)2.16467347
78Constricted visual fields (HP:0001133)2.16004919
79Neoplasm of the pancreas (HP:0002894)2.15678088
80Hepatocellular necrosis (HP:0001404)2.13657059
81Abnormal number of incisors (HP:0011064)2.12820160
82Long eyelashes (HP:0000527)2.12812115
83Small intestinal stenosis (HP:0012848)2.11045402
84Duodenal stenosis (HP:0100867)2.11045402
85Methylmalonic acidemia (HP:0002912)2.10722928
86Decreased electroretinogram (ERG) amplitude (HP:0000654)2.07003246
87Duplicated collecting system (HP:0000081)2.06713095
88Chronic otitis media (HP:0000389)2.06153214
89Prominent metopic ridge (HP:0005487)2.05778063
90Abnormality of the renal collecting system (HP:0004742)2.05590145
91Ectopic kidney (HP:0000086)2.05465841
92Slender long bone (HP:0003100)2.05373271
93Hemiparesis (HP:0001269)2.03349051
94Tracheoesophageal fistula (HP:0002575)2.00992752
95Atresia of the external auditory canal (HP:0000413)2.00226330
96Absent thumb (HP:0009777)2.00218743
97Mitochondrial inheritance (HP:0001427)1.99960359
98Microretrognathia (HP:0000308)1.99587392
99Type II lissencephaly (HP:0007260)1.98986528
100Tubulointerstitial nephritis (HP:0001970)1.98661471
101Pallor (HP:0000980)1.97556048
102Proximal placement of thumb (HP:0009623)1.97506437
103Hepatic necrosis (HP:0002605)1.96655961
10411 pairs of ribs (HP:0000878)1.95688933
105Carpal bone hypoplasia (HP:0001498)1.95587969
106Agnosia (HP:0010524)1.95133931
107Aplasia/Hypoplasia of the tibia (HP:0005772)1.95115053
108Pancytopenia (HP:0001876)1.95075811
109Concave nail (HP:0001598)1.93578882
110Cleft eyelid (HP:0000625)1.93578036
111Abnormal lung lobation (HP:0002101)1.92825729
112Large for gestational age (HP:0001520)1.92453196
113Abnormality of the carotid arteries (HP:0005344)1.91894343
114Increased serum lactate (HP:0002151)1.90439739
115Impulsivity (HP:0100710)1.89999178
116Prominent nose (HP:0000448)1.89746170
117Trismus (HP:0000211)1.89469787
118Overlapping toe (HP:0001845)1.88632802
119Congenital hepatic fibrosis (HP:0002612)1.87838754
120Neoplasm of the adrenal cortex (HP:0100641)1.87374816
121Sloping forehead (HP:0000340)1.87071356
122Poor coordination (HP:0002370)1.86796142
123Progressive cerebellar ataxia (HP:0002073)1.86722813
124Recurrent viral infections (HP:0004429)1.85938834
125Poikiloderma (HP:0001029)1.85398441
126Short 4th metacarpal (HP:0010044)1.84675917
127Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.84675917
128Abnormality of the metopic suture (HP:0005556)1.83582084
129Prolonged bleeding time (HP:0003010)1.83155493
130Pendular nystagmus (HP:0012043)1.82759873
131Abnormality of homocysteine metabolism (HP:0010919)1.82723435
132Homocystinuria (HP:0002156)1.82723435
133Cellular immunodeficiency (HP:0005374)1.82322168
134Hyperacusis (HP:0010780)1.81907290
135Deviation of the thumb (HP:0009603)1.81794756
136Panhypogammaglobulinemia (HP:0003139)1.81024066
137Volvulus (HP:0002580)1.80215484
138Abnormal rod and cone electroretinograms (HP:0008323)1.79978060
139Abnormality of T cells (HP:0002843)1.79764118
140Male pseudohermaphroditism (HP:0000037)1.79529717
141Aganglionic megacolon (HP:0002251)1.79473864
142IgG deficiency (HP:0004315)1.79355280
143Increased CSF lactate (HP:0002490)1.79252812
144Aplasia involving forearm bones (HP:0009822)1.78991254
145Absent forearm bone (HP:0003953)1.78991254
146Aplasia/hypoplasia of the uterus (HP:0008684)1.78277653
147Poor head control (HP:0002421)1.77159361
148Abnormality of the calcaneus (HP:0008364)1.76867627
149Atrophy/Degeneration involving motor neurons (HP:0007373)1.76638546
150Broad foot (HP:0001769)1.76634262
151Calcaneovalgus deformity (HP:0001848)1.76574701
152Renal duplication (HP:0000075)1.76099747
153Absent radius (HP:0003974)1.75853797
154Acute myeloid leukemia (HP:0004808)1.75766728
155Severe combined immunodeficiency (HP:0004430)1.74959522
156Abnormal trabecular bone morphology (HP:0100671)1.74879780
157Hypoplasia of the capital femoral epiphysis (HP:0003090)1.74840061
158Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.74484986
159Spinal muscular atrophy (HP:0007269)1.73287004
160Elevated erythrocyte sedimentation rate (HP:0003565)1.73180508
161Abnormality of the renal cortex (HP:0011035)1.72921667
162Severe visual impairment (HP:0001141)1.72224100
163Abnormality of DNA repair (HP:0003254)1.72046390
164Abnormality of the duodenum (HP:0002246)1.71039892
165Postaxial hand polydactyly (HP:0001162)1.70938333
166Absent rod-and cone-mediated responses on ERG (HP:0007688)1.70673607
167Intestinal atresia (HP:0011100)1.69887163
168Retinitis pigmentosa (HP:0000510)1.68475040
169Recurrent bronchitis (HP:0002837)1.68264166
170Genital tract atresia (HP:0001827)1.68061066
171Type II diabetes mellitus (HP:0005978)1.67946534
172Progressive microcephaly (HP:0000253)1.67741276
173Cafe-au-lait spot (HP:0000957)1.67497157
174Macrocytic anemia (HP:0001972)1.65950016
175Bony spicule pigmentary retinopathy (HP:0007737)1.65923288
176Oligodactyly (hands) (HP:0001180)1.65529590
177Optic disc pallor (HP:0000543)1.64733180
178Broad palm (HP:0001169)1.64658611
179Multiple enchondromatosis (HP:0005701)1.64341474
180Dandy-Walker malformation (HP:0001305)1.64306630
181Basal cell carcinoma (HP:0002671)1.64232125
182Clubbing of toes (HP:0100760)1.64166451
183Abnormality of cells of the lymphoid lineage (HP:0012140)1.63657080

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.45566890
2FRK4.12100313
3VRK23.71671104
4WEE13.58970119
5TAOK33.19754796
6CDC73.03372078
7TSSK62.80447174
8NUAK12.79868198
9MAP4K22.78349880
10EIF2AK12.65841953
11MAP4K12.60732314
12BCKDK2.50961480
13STK162.47564540
14ADRBK22.46591236
15NEK22.32748859
16GRK12.31432577
17MAP3K102.25290507
18BMPR1B2.24379583
19BRSK22.22417090
20WNK32.03413014
21MKNK12.01215937
22ACVR1B2.00208319
23SRPK11.89514800
24CDK191.84257638
25TRIM281.80654143
26DYRK21.75981245
27MAP3K41.75364483
28TESK21.71549587
29PASK1.71027490
30ATR1.68314100
31MAPK131.67157233
32CDK71.64871469
33INSRR1.62819294
34STK101.60588633
35RPS6KA41.58634814
36DYRK31.52321540
37CDK121.52173487
38PLK11.49321070
39FLT31.44856120
40EEF2K1.44583291
41NEK11.43260179
42TNK21.43044701
43CSNK1G31.42618666
44PLK41.40455849
45TXK1.38803465
46MKNK21.38761039
47BTK1.36581917
48KIT1.35240390
49CDK41.35080385
50PINK11.34851679
51TLK11.33682719
52CCNB11.33173686
53RPS6KB21.31678121
54BRD41.29856394
55TTK1.27524728
56TGFBR11.26442572
57PIM21.25302998
58BRSK11.23432383
59VRK11.21999851
60MAP2K71.21191177
61AURKB1.19788804
62CASK1.18004170
63SIK21.17338589
64NME21.16763144
65ZAP701.16708597
66DAPK21.16654738
67CSNK1G11.15523461
68PAK41.13689439
69CSNK1A1L1.10410192
70EIF2AK31.05479653
71JAK31.04196918
72STK41.03593175
73MAP3K111.03246065
74PLK31.00365759
75PIM11.00345287
76SIK31.00156001
77IRAK40.91958307
78CSNK1G20.90428281
79CHEK10.90338343
80FES0.90193776
81STK30.90175512
82LRRK20.88436028
83CDK80.88241939
84CSF1R0.87266703
85MAP3K80.86235586
86CHEK20.86095046
87KDR0.85904885
88CLK10.83978034
89ZAK0.83097422
90PTK2B0.82574890
91TRIB30.82494332
92DAPK10.77767856
93MARK10.76163221
94ADRBK10.74881794
95AURKA0.74311099
96TEC0.72820983
97SCYL20.72669300
98ALK0.71560502
99* CDK20.71397419
100WNK40.71186194
101MATK0.68032867
102PRKCQ0.66593678
103CHUK0.66423786
104NLK0.65776169
105CDK90.65524226
106BLK0.63937946
107TBK10.62327036
108PRKCE0.60450886
109GRK60.60350942
110YES10.60081558
111PAK10.59959307
112TYK20.59465655
113ILK0.58679732
114AKT30.58534331
115ATM0.58178253
116MAP2K30.57213896
117NTRK30.56946146
118IKBKB0.56937486
119PRKCZ0.54466109
120DYRK1A0.54160362
121RAF10.54061534
122PRKCG0.52657486
123NME10.52493194
124EPHA30.50478167
125BCR0.49405135
126* CSNK1A10.49236953
127CDK10.48655402
128CSNK2A10.48254858
129SYK0.48209738
130CSNK2A20.47780610
131NTRK20.47536439
132MTOR0.46508028
133MAPKAPK20.46340623
134ITK0.46015639
135IKBKE0.45839729
136PKN20.45808911
137PAK30.45747399
138TESK10.45089674
139PRKD20.44244289
140RPS6KA50.42657677
141CDK30.42493172
142HIPK20.42151579
143CDK60.41542568
144NEK90.41166805
145LCK0.41089532
146EPHA20.40517722
147CSNK1D0.40435740
148LYN0.39323963
149MAPKAPK30.38857118
150PRKCI0.38551443
151RPS6KA60.38407498
152BRAF0.37347380
153FER0.33983794
154MAPK110.33696923
155MAP2K40.32775077
156PRKAA10.32681703
157PDK20.32254528

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.51477038
2Mismatch repair_Homo sapiens_hsa034303.65947250
3Spliceosome_Homo sapiens_hsa030403.20361107
4Base excision repair_Homo sapiens_hsa034103.00710830
5RNA polymerase_Homo sapiens_hsa030202.98513405
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.81615242
7Homologous recombination_Homo sapiens_hsa034402.71794328
8Cell cycle_Homo sapiens_hsa041102.65545035
9RNA transport_Homo sapiens_hsa030132.64538556
10Ribosome_Homo sapiens_hsa030102.60630988
11Proteasome_Homo sapiens_hsa030502.55441860
12Nucleotide excision repair_Homo sapiens_hsa034202.46614461
13Phototransduction_Homo sapiens_hsa047442.40463789
14Pyrimidine metabolism_Homo sapiens_hsa002402.12738427
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.09066449
16One carbon pool by folate_Homo sapiens_hsa006701.96495741
17Fanconi anemia pathway_Homo sapiens_hsa034601.83462418
18Basal transcription factors_Homo sapiens_hsa030221.80795755
19mRNA surveillance pathway_Homo sapiens_hsa030151.75245477
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.70553758
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.69512827
22RNA degradation_Homo sapiens_hsa030181.66377007
23Butanoate metabolism_Homo sapiens_hsa006501.64841503
24Non-homologous end-joining_Homo sapiens_hsa034501.55558290
25p53 signaling pathway_Homo sapiens_hsa041151.52016105
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.47012204
27Epstein-Barr virus infection_Homo sapiens_hsa051691.45448940
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.45063795
29Herpes simplex infection_Homo sapiens_hsa051681.44816877
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.44151733
31Primary immunodeficiency_Homo sapiens_hsa053401.41404100
32Oxidative phosphorylation_Homo sapiens_hsa001901.41128620
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.39814955
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.39481128
35Antigen processing and presentation_Homo sapiens_hsa046121.38464223
36Nicotine addiction_Homo sapiens_hsa050331.35881836
37Maturity onset diabetes of the young_Homo sapiens_hsa049501.34073670
38Parkinsons disease_Homo sapiens_hsa050121.32052047
39Olfactory transduction_Homo sapiens_hsa047401.28540438
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.24791955
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.21864756
42Propanoate metabolism_Homo sapiens_hsa006401.18828261
43Purine metabolism_Homo sapiens_hsa002301.16126079
44Taste transduction_Homo sapiens_hsa047421.15275449
45Measles_Homo sapiens_hsa051621.15100690
46Nitrogen metabolism_Homo sapiens_hsa009101.13933676
47Lysine degradation_Homo sapiens_hsa003101.13652107
48alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.11655997
49Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.10471593
50Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.08913760
51Huntingtons disease_Homo sapiens_hsa050161.07265096
52Legionellosis_Homo sapiens_hsa051341.06895811
53NF-kappa B signaling pathway_Homo sapiens_hsa040641.00821210
54Viral carcinogenesis_Homo sapiens_hsa052031.00624422
55GABAergic synapse_Homo sapiens_hsa047270.96290125
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.94346672
57HTLV-I infection_Homo sapiens_hsa051660.93449832
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.91194630
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.90822368
60Ether lipid metabolism_Homo sapiens_hsa005650.89499716
61Fatty acid elongation_Homo sapiens_hsa000620.87856289
62Notch signaling pathway_Homo sapiens_hsa043300.87422421
63Collecting duct acid secretion_Homo sapiens_hsa049660.86209871
64ABC transporters_Homo sapiens_hsa020100.84232144
65Morphine addiction_Homo sapiens_hsa050320.83934656
66Peroxisome_Homo sapiens_hsa041460.82315153
67Linoleic acid metabolism_Homo sapiens_hsa005910.81452470
68Leishmaniasis_Homo sapiens_hsa051400.81305467
69Transcriptional misregulation in cancer_Homo sapiens_hsa052020.81153644
70Hematopoietic cell lineage_Homo sapiens_hsa046400.80338236
71Thyroid cancer_Homo sapiens_hsa052160.80200653
72Acute myeloid leukemia_Homo sapiens_hsa052210.79757682
73Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.78314222
74Apoptosis_Homo sapiens_hsa042100.78245997
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78110602
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.77191202
77Shigellosis_Homo sapiens_hsa051310.76910303
78Chronic myeloid leukemia_Homo sapiens_hsa052200.75557711
79RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.74685198
80Viral myocarditis_Homo sapiens_hsa054160.72678063
81Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.71247217
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71239160
83Cyanoamino acid metabolism_Homo sapiens_hsa004600.70641916
84Oocyte meiosis_Homo sapiens_hsa041140.70300554
85Steroid biosynthesis_Homo sapiens_hsa001000.70121052
86Intestinal immune network for IgA production_Homo sapiens_hsa046720.69679010
87Small cell lung cancer_Homo sapiens_hsa052220.68889062
88Metabolic pathways_Homo sapiens_hsa011000.68179142
89Influenza A_Homo sapiens_hsa051640.67038046
90Protein export_Homo sapiens_hsa030600.66537310
91N-Glycan biosynthesis_Homo sapiens_hsa005100.66214855
92Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.65247775
93Hepatitis B_Homo sapiens_hsa051610.64734206
94Tryptophan metabolism_Homo sapiens_hsa003800.63320608
95Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.63075895
96Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.62607902
97NOD-like receptor signaling pathway_Homo sapiens_hsa046210.61748130
98Pentose phosphate pathway_Homo sapiens_hsa000300.61408128
99Vitamin B6 metabolism_Homo sapiens_hsa007500.59273040
100B cell receptor signaling pathway_Homo sapiens_hsa046620.58079763
101MicroRNAs in cancer_Homo sapiens_hsa052060.57254571
102Colorectal cancer_Homo sapiens_hsa052100.56355109
103Jak-STAT signaling pathway_Homo sapiens_hsa046300.54783358
104Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53591887
1052-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.51439205
106Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.50788951
107Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.50040679
108Regulation of autophagy_Homo sapiens_hsa041400.49496759
109Allograft rejection_Homo sapiens_hsa053300.46916022
110Graft-versus-host disease_Homo sapiens_hsa053320.45780112
111Folate biosynthesis_Homo sapiens_hsa007900.45346288
112Toxoplasmosis_Homo sapiens_hsa051450.45280505
113Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44852688
114T cell receptor signaling pathway_Homo sapiens_hsa046600.44586075
115Hedgehog signaling pathway_Homo sapiens_hsa043400.44516993
116Circadian entrainment_Homo sapiens_hsa047130.44240163
117Toll-like receptor signaling pathway_Homo sapiens_hsa046200.44022365
118Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.43911945
119Ovarian steroidogenesis_Homo sapiens_hsa049130.42867524
120Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.42759703
121Asthma_Homo sapiens_hsa053100.42226929
122Systemic lupus erythematosus_Homo sapiens_hsa053220.41345309
123Serotonergic synapse_Homo sapiens_hsa047260.41167352
124Hippo signaling pathway_Homo sapiens_hsa043900.40758340
125Glycerolipid metabolism_Homo sapiens_hsa005610.39833214
126Basal cell carcinoma_Homo sapiens_hsa052170.39410672
127Leukocyte transendothelial migration_Homo sapiens_hsa046700.39257296
128Biosynthesis of amino acids_Homo sapiens_hsa012300.39222539
129Pathways in cancer_Homo sapiens_hsa052000.39135074
130Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.38923849
131Neurotrophin signaling pathway_Homo sapiens_hsa047220.38843716
132HIF-1 signaling pathway_Homo sapiens_hsa040660.37288279
133Pancreatic cancer_Homo sapiens_hsa052120.36518749
134Glycerophospholipid metabolism_Homo sapiens_hsa005640.35926488
135Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.35593531
136Fructose and mannose metabolism_Homo sapiens_hsa000510.34880487
137Fatty acid metabolism_Homo sapiens_hsa012120.34799048
138Selenocompound metabolism_Homo sapiens_hsa004500.34082424
139Non-small cell lung cancer_Homo sapiens_hsa052230.33688581
140Autoimmune thyroid disease_Homo sapiens_hsa053200.32219390
141Osteoclast differentiation_Homo sapiens_hsa043800.31702202
142Calcium signaling pathway_Homo sapiens_hsa040200.31370513
143mTOR signaling pathway_Homo sapiens_hsa041500.31229817
144Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.31139859
145Cysteine and methionine metabolism_Homo sapiens_hsa002700.31067709
146Alzheimers disease_Homo sapiens_hsa050100.28396611
147Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.26830388
148Galactose metabolism_Homo sapiens_hsa000520.26378277
149Sulfur relay system_Homo sapiens_hsa041220.26349004
150Platelet activation_Homo sapiens_hsa046110.26344884
151Synaptic vesicle cycle_Homo sapiens_hsa047210.25824391
152FoxO signaling pathway_Homo sapiens_hsa040680.25462537
153Type I diabetes mellitus_Homo sapiens_hsa049400.25107581
154Long-term depression_Homo sapiens_hsa047300.24847906
155SNARE interactions in vesicular transport_Homo sapiens_hsa041300.23757655

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