DPF3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the D4 protein family. The encoded protein is a transcription regulator that binds acetylated histones and is a component of the BAF chromatin remodeling complex. Alternate splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of rhodopsin mediated signaling pathway (GO:0022400)8.57718979
2rhodopsin mediated signaling pathway (GO:0016056)8.44520959
3retinal cone cell development (GO:0046549)6.79015111
4photoreceptor cell maintenance (GO:0045494)6.22115891
5photoreceptor cell development (GO:0042461)6.07492697
6sarcoplasmic reticulum calcium ion transport (GO:0070296)6.06115018
7detection of light stimulus involved in visual perception (GO:0050908)5.89875416
8detection of light stimulus involved in sensory perception (GO:0050962)5.89875416
9eye photoreceptor cell development (GO:0042462)5.74447303
10regulation of actin filament-based movement (GO:1903115)5.53578201
11retinal rod cell development (GO:0046548)5.23131960
12GMP metabolic process (GO:0046037)5.00626082
13positive regulation of guanylate cyclase activity (GO:0031284)4.91285117
14response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.85746385
15regulation of guanylate cyclase activity (GO:0031282)4.65130033
16phototransduction (GO:0007602)4.61246624
17actin filament-based movement (GO:0030048)4.60395081
18detection of light stimulus (GO:0009583)4.58691560
19detection of visible light (GO:0009584)4.49499814
20phototransduction, visible light (GO:0007603)4.48785238
21regulation of cell communication by electrical coupling (GO:0010649)4.45113676
22regulation of the force of heart contraction (GO:0002026)4.35135976
23striated muscle hypertrophy (GO:0014897)4.34893975
24visual perception (GO:0007601)4.29952683
25response to pheromone (GO:0019236)4.28659402
26sensory perception of light stimulus (GO:0050953)4.28569442
27protein-chromophore linkage (GO:0018298)4.27265879
28eye photoreceptor cell differentiation (GO:0001754)4.27004221
29photoreceptor cell differentiation (GO:0046530)4.27004221
30actomyosin structure organization (GO:0031032)4.26837006
31skeletal muscle contraction (GO:0003009)4.21181786
32regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.20624972
33regulation of cardiac muscle cell contraction (GO:0086004)4.07880988
34protein K11-linked deubiquitination (GO:0035871)3.99587320
35response to inactivity (GO:0014854)3.98628904
36negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.91970782
37retina development in camera-type eye (GO:0060041)3.88046070
38cellular response to light stimulus (GO:0071482)3.83718668
39muscle tissue morphogenesis (GO:0060415)3.77466618
40cardiac muscle tissue morphogenesis (GO:0055008)3.77119896
41cardiac myofibril assembly (GO:0055003)3.74997719
42muscle hypertrophy (GO:0014896)3.74012617
43regulation of striated muscle contraction (GO:0006942)3.72743515
44muscle contraction (GO:0006936)3.68573521
45response to muscle activity (GO:0014850)3.56302813
46regulation of sarcomere organization (GO:0060297)3.54880020
47detection of external stimulus (GO:0009581)3.51248234
48detection of abiotic stimulus (GO:0009582)3.46734865
49regulation of cGMP metabolic process (GO:0030823)3.46297104
50cardiac muscle hypertrophy in response to stress (GO:0014898)3.44303815
51muscle hypertrophy in response to stress (GO:0003299)3.44303815
52cardiac muscle adaptation (GO:0014887)3.44303815
53cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.44033355
54relaxation of cardiac muscle (GO:0055119)3.42534902
55muscle system process (GO:0003012)3.41000612
56regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.40132908
57striated muscle adaptation (GO:0014888)3.37341905
58piRNA metabolic process (GO:0034587)3.35765032
59negative regulation of cytosolic calcium ion concentration (GO:0051481)3.35467152
60positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.34293330
61synaptic vesicle endocytosis (GO:0048488)3.32305648
62skeletal muscle fiber development (GO:0048741)3.29728691
63negative regulation of protein localization to cell surface (GO:2000009)3.25964578
64myotube cell development (GO:0014904)3.19506059
65plasma membrane repair (GO:0001778)3.18904283
66receptor guanylyl cyclase signaling pathway (GO:0007168)3.18843308
67positive regulation of sodium ion transmembrane transport (GO:1902307)3.18797598
68positive regulation of cGMP biosynthetic process (GO:0030828)3.18320964
69muscle cell fate commitment (GO:0042693)3.16891247
70nonmotile primary cilium assembly (GO:0035058)3.16801155
71ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.14909073
72muscle fiber development (GO:0048747)3.14592003
73myofibril assembly (GO:0030239)3.14075357
74cardiac muscle cell development (GO:0055013)3.12827182
75regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.11996233
76regulation of cGMP biosynthetic process (GO:0030826)3.11946421
77regulation of membrane repolarization (GO:0060306)3.11618666
78cell communication by electrical coupling (GO:0010644)3.11591127
79peripheral nervous system axon ensheathment (GO:0032292)3.10803124
80myelination in peripheral nervous system (GO:0022011)3.10803124
81positive regulation of cardiac muscle cell differentiation (GO:2000727)3.07794594
82regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.07452697
83positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.05520203
84skeletal muscle adaptation (GO:0043501)3.04132758
85sodium ion export (GO:0071436)3.01943689
86cardiac cell development (GO:0055006)3.00833965
87potassium ion export (GO:0071435)3.00784622
88striated muscle cell development (GO:0055002)2.99282693
89cardiac muscle contraction (GO:0060048)2.99054354
90G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.95983926
91relaxation of muscle (GO:0090075)2.95807015
92positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.92853777
93regulation of cardioblast differentiation (GO:0051890)2.91581128
94positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.88483548
95regulation of heart rate (GO:0002027)2.87348785
96regulation of cardiac muscle contraction (GO:0055117)2.87039905
97neuromuscular synaptic transmission (GO:0007274)2.86330487
98lymphangiogenesis (GO:0001946)2.84007349
99sarcomere organization (GO:0045214)2.83462957
100regulation of calcium ion transmembrane transporter activity (GO:1901019)2.82825846
101regulation of calcium ion transmembrane transport (GO:1903169)2.82825846
102regulation of transforming growth factor beta2 production (GO:0032909)2.81592822
103positive regulation of cation channel activity (GO:2001259)2.81170115
104ventricular cardiac muscle cell action potential (GO:0086005)2.81043889
105response to epinephrine (GO:0071871)2.80413711
106positive regulation of cGMP metabolic process (GO:0030825)2.79246513
107muscle filament sliding (GO:0030049)2.79182750
108actin-myosin filament sliding (GO:0033275)2.79182750
109regulation of sequestering of triglyceride (GO:0010889)2.78499560
110cellular response to epinephrine stimulus (GO:0071872)2.77833762
111mitotic metaphase plate congression (GO:0007080)2.76388669
112regulation of heart contraction (GO:0008016)2.76319827
113skeletal muscle tissue development (GO:0007519)2.74930598
114endocardial cushion development (GO:0003197)2.73139544
115regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.71889562
116cardiac chamber formation (GO:0003207)2.71521219
117regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.71415784
118regulation of muscle contraction (GO:0006937)2.71305131
119regulation of short-term neuronal synaptic plasticity (GO:0048172)2.70454589
120muscle organ development (GO:0007517)2.70330991
121regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.69812467
122regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.69702745
123negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.69308117
124striated muscle atrophy (GO:0014891)2.69277337
125muscle structure development (GO:0061061)2.69079645
126regulation of muscle system process (GO:0090257)2.67660537
127male meiosis (GO:0007140)2.67056224
128positive regulation of potassium ion transmembrane transport (GO:1901381)2.65684553
129negative regulation of hormone biosynthetic process (GO:0032353)2.63210407
130negative regulation of hormone metabolic process (GO:0032351)2.63210407
131cardiac muscle cell action potential (GO:0086001)2.60813647
132behavioral response to ethanol (GO:0048149)2.60141512
133glycogen catabolic process (GO:0005980)2.59548618
134regulation of ATPase activity (GO:0043462)2.59326274
135regulation of ATP catabolic process (GO:1903289)2.59326274
136actin-mediated cell contraction (GO:0070252)2.58838286
137regulation of voltage-gated calcium channel activity (GO:1901385)2.56570129
138coronary vasculature morphogenesis (GO:0060977)2.56249177
139regulation of skeletal muscle contraction (GO:0014819)2.55241820
140muscle adaptation (GO:0043500)2.55094206
141muscle cell development (GO:0055001)2.55025388
142adult heart development (GO:0007512)2.54664111
143positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.54216439
144axoneme assembly (GO:0035082)2.53379063
145membrane depolarization during action potential (GO:0086010)2.52993148
146atrial cardiac muscle cell action potential (GO:0086014)2.52980971
147negative regulation of potassium ion transmembrane transport (GO:1901380)2.52394708
148cellular potassium ion homeostasis (GO:0030007)2.51829724
149striated muscle contraction (GO:0006941)2.46344436
150lactate metabolic process (GO:0006089)2.45736217
151positive regulation of mRNA 3-end processing (GO:0031442)2.44509580
152ventricular cardiac muscle cell development (GO:0055015)2.44302232
153protein polyglutamylation (GO:0018095)2.43640820
154microtubule depolymerization (GO:0007019)2.43527120
155cellular sodium ion homeostasis (GO:0006883)2.43274310
156negative regulation of transcription regulatory region DNA binding (GO:2000678)2.43245917
157positive regulation of synapse maturation (GO:0090129)2.42720677
158potassium ion homeostasis (GO:0055075)2.42231182
159regulation of relaxation of muscle (GO:1901077)2.40549471
160glycolytic process (GO:0006096)2.40278879
161calcium ion import (GO:0070509)2.39686202
162cellular response to radiation (GO:0071478)2.39053133
163cell communication involved in cardiac conduction (GO:0086065)2.39033806
164cardiac muscle cell action potential involved in contraction (GO:0086002)2.38814030
165cardiac muscle hypertrophy (GO:0003300)2.38011599
166positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.34407072
167membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.33251428
168cerebellar Purkinje cell differentiation (GO:0021702)2.32676935
169sperm motility (GO:0030317)2.31880574

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.20938554
2RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.80168505
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.46757918
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.29541518
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.21499468
6SMAD_19615063_ChIP-ChIP_OVARY_Human2.08889692
7CDX2_19796622_ChIP-Seq_MESCs_Mouse2.06995851
8ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.06303060
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.04053298
10GBX2_23144817_ChIP-Seq_PC3_Human1.91902051
11SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.89606651
12CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.88443983
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.82934916
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.82013217
15* EED_16625203_ChIP-ChIP_MESCs_Mouse1.80844478
16CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.80568313
17CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.78952827
18VDR_22108803_ChIP-Seq_LS180_Human1.76748103
19* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.75668327
20EP300_21415370_ChIP-Seq_HL-1_Mouse1.74600766
21AR_21572438_ChIP-Seq_LNCaP_Human1.74354703
22REST_21632747_ChIP-Seq_MESCs_Mouse1.73182894
23RBPJ_22232070_ChIP-Seq_NCS_Mouse1.59536791
24* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.58919700
25TAF15_26573619_Chip-Seq_HEK293_Human1.58859219
26TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.58110435
27* EZH2_27294783_Chip-Seq_ESCs_Mouse1.54211403
28WDR5_24793694_ChIP-Seq_LNCAP_Human1.53130678
29TP53_16413492_ChIP-PET_HCT116_Human1.52144343
30* CBX2_27304074_Chip-Seq_ESCs_Mouse1.45881220
31TP53_18474530_ChIP-ChIP_U2OS_Human1.45832173
32* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.43884223
33MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.43194074
34* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.42302250
35* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.42210714
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40842442
37REST_18959480_ChIP-ChIP_MESCs_Mouse1.40715787
38SMAD3_21741376_ChIP-Seq_EPCs_Human1.40529921
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.40013913
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.39278893
41TBX20_22328084_ChIP-Seq_HEART_Mouse1.38575049
42TBX20_22080862_ChIP-Seq_HEART_Mouse1.38575049
43ESR1_20079471_ChIP-ChIP_T-47D_Human1.36114978
44POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.34345083
45TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34345083
46* TBL1_22424771_ChIP-Seq_293T_Human1.33130462
47* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30925207
48AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.30562134
49* RNF2_27304074_Chip-Seq_ESCs_Mouse1.29698252
50SMAD4_21799915_ChIP-Seq_A2780_Human1.28939913
51* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.28627407
52CJUN_26792858_Chip-Seq_BT549_Human1.28053880
53* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26495745
54TP63_19390658_ChIP-ChIP_HaCaT_Human1.25256436
55POU3F2_20337985_ChIP-ChIP_501MEL_Human1.24854454
56* EZH2_27304074_Chip-Seq_ESCs_Mouse1.23921197
57SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.23881855
58FOXM1_23109430_ChIP-Seq_U2OS_Human1.21456804
59CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.21322321
60KAP1_22055183_ChIP-Seq_ESCs_Mouse1.20726151
61DROSHA_22980978_ChIP-Seq_HELA_Human1.20463085
62NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.19826128
63RNF2_27304074_Chip-Seq_NSC_Mouse1.19731678
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.19059135
65E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.18220148
66SMAD4_21741376_ChIP-Seq_EPCs_Human1.17627897
67AR_19668381_ChIP-Seq_PC3_Human1.17546051
68* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.17514512
69SMAD3_21741376_ChIP-Seq_HESCs_Human1.17510542
70SMAD4_21741376_ChIP-Seq_HESCs_Human1.17437203
71P300_19829295_ChIP-Seq_ESCs_Human1.16794176
72* STAT3_23295773_ChIP-Seq_U87_Human1.15122262
73* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.14861915
74* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.14450280
75* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.14098540
76* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.14098540
77* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.13440854
78NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13242156
79IGF1R_20145208_ChIP-Seq_DFB_Human1.12858605
80NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.12581851
81KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.12432920
82ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11357515
83RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.11342615
84CTNNB1_20460455_ChIP-Seq_HCT116_Human1.11317290
85ZNF274_21170338_ChIP-Seq_K562_Hela1.11052925
86IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.10710051
87* ER_23166858_ChIP-Seq_MCF-7_Human1.10598808
88* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09988881
89EZH2_27294783_Chip-Seq_NPCs_Mouse1.08162652
90FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.07907756
91MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.07517678
92* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.05869651
93TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03361408
94NR3C1_23031785_ChIP-Seq_PC12_Mouse1.02990217
95ZFP57_27257070_Chip-Seq_ESCs_Mouse1.02480533
96FLI1_27457419_Chip-Seq_LIVER_Mouse1.01926901
97ISL1_27105846_Chip-Seq_CPCs_Mouse1.01257012
98ETV1_20927104_ChIP-Seq_GIST48_Human1.00486217
99PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.00223389
100TCF4_23295773_ChIP-Seq_U87_Human0.99652907
101NANOG_18555785_Chip-Seq_ESCs_Mouse0.98750718
102ARNT_22903824_ChIP-Seq_MCF-7_Human0.98684001
103* JARID2_20075857_ChIP-Seq_MESCs_Mouse0.98518079
104BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98355831
105CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98154575
106TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98051449
107* GF1_26923725_Chip-Seq_HPCs_Mouse0.97844431
108SUZ12_27294783_Chip-Seq_NPCs_Mouse0.97665848
109SOX9_26525672_Chip-Seq_HEART_Mouse0.97578160
110KDM2B_26808549_Chip-Seq_REH_Human0.97555397
111* GATA1_26923725_Chip-Seq_HPCs_Mouse0.97451693
112WT1_19549856_ChIP-ChIP_CCG9911_Human0.97211284
113EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.97032741
114NFYA_21822215_ChIP-Seq_K562_Human0.96886306
115* FLI1_21867929_ChIP-Seq_TH2_Mouse0.96840942
116KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.96752199
117* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.96733906
118* RUNX1_26923725_Chip-Seq_HPCs_Mouse0.96520761
119CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95828041
120NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.95670453
121SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.95410064
122* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.95080157
123* AR_25329375_ChIP-Seq_VCAP_Human0.95067287
124PCGF2_27294783_Chip-Seq_NPCs_Mouse0.94670906
125NRF2_20460467_ChIP-Seq_MEFs_Mouse0.94571856
126* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.94432609
127SALL1_21062744_ChIP-ChIP_HESCs_Human0.94411344
128POU5F1_16153702_ChIP-ChIP_HESCs_Human0.93644379
129BMI1_23680149_ChIP-Seq_NPCS_Mouse0.90485958
130P53_22127205_ChIP-Seq_FIBROBLAST_Human0.90030693
131CTBP1_25329375_ChIP-Seq_LNCAP_Human0.89913666
132NFYB_21822215_ChIP-Seq_K562_Human0.89213669
133MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.88722730
134* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.88408116
135KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.88069967
136PHF8_20622853_ChIP-Seq_HELA_Human0.88050049
137* ELK4_26923725_Chip-Seq_MESODERM_Mouse0.87574982
138TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87459339
139LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87368016
140* SOX2_21211035_ChIP-Seq_LN229_Gbm0.87276621
141YAP1_20516196_ChIP-Seq_MESCs_Mouse0.86398198
142STAT1_17558387_ChIP-Seq_HELA_Human0.86213035
143* RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.86031573
144CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.85663356
145EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.84918433
146CBP_20019798_ChIP-Seq_JUKART_Human0.84778458

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005551_abnormal_eye_electrophysiolog5.86457936
2MP0003011_delayed_dark_adaptation4.59323968
3MP0006072_abnormal_retinal_apoptosis4.25334014
4MP0005253_abnormal_eye_physiology3.98695667
5MP0003646_muscle_fatigue3.08889743
6MP0002638_abnormal_pupillary_reflex2.85431459
7MP0003950_abnormal_plasma_membrane2.83943610
8MP0004084_abnormal_cardiac_muscle2.74387673
9MP0004130_abnormal_muscle_cell2.68515317
10MP0004215_abnormal_myocardial_fiber2.56382506
11MP0004145_abnormal_muscle_electrophysio2.40457694
12MP0005195_abnormal_posterior_eye2.37828390
13MP0000747_muscle_weakness2.32048662
14MP0005423_abnormal_somatic_nervous2.09615960
15MP0004510_myositis2.05953413
16MP0004036_abnormal_muscle_relaxation2.05630815
17MP0002653_abnormal_ependyma_morphology1.97672061
18MP0005391_vision/eye_phenotype1.91857500
19MP0000733_abnormal_muscle_development1.84909887
20MP0001324_abnormal_eye_pigmentation1.84151902
21MP0002837_dystrophic_cardiac_calcinosis1.82893780
22MP0001984_abnormal_olfaction1.76998150
23MP0002127_abnormal_cardiovascular_syste1.71502183
24MP0000751_myopathy1.69469439
25MP0006292_abnormal_olfactory_placode1.67887864
26MP0000749_muscle_degeneration1.67484496
27MP0009780_abnormal_chondrocyte_physiolo1.60703079
28MP0002735_abnormal_chemical_nociception1.58068010
29MP0004233_abnormal_muscle_weight1.57849616
30MP0002752_abnormal_somatic_nervous1.54122630
31MP0002229_neurodegeneration1.54060115
32MP0003718_maternal_effect1.53626671
33MP0003137_abnormal_impulse_conducting1.51330666
34MP0001986_abnormal_taste_sensitivity1.47253206
35MP0005620_abnormal_muscle_contractility1.42576681
36MP0003183_abnormal_peptide_metabolism1.40296741
37MP0002108_abnormal_muscle_morphology1.40031583
38MP0008877_abnormal_DNA_methylation1.35894932
39MP0001502_abnormal_circadian_rhythm1.34505313
40MP0002090_abnormal_vision1.34287339
41MP0005451_abnormal_body_composition1.34202088
42MP0008775_abnormal_heart_ventricle1.32934501
43MP0002972_abnormal_cardiac_muscle1.31628031
44MP0005410_abnormal_fertilization1.31272190
45MP0004085_abnormal_heartbeat1.27390823
46MP0002102_abnormal_ear_morphology1.24190626
47MP0001879_abnormal_lymphatic_vessel1.20442687
48MP0001299_abnormal_eye_distance/1.19801980
49MP0005330_cardiomyopathy1.19571692
50MP0002882_abnormal_neuron_morphology1.16828906
51MP0003111_abnormal_nucleus_morphology1.16114515
52MP0002269_muscular_atrophy1.15220875
53MP0004147_increased_porphyrin_level1.15172841
54MP0003698_abnormal_male_reproductive1.14592354
55MP0001929_abnormal_gametogenesis1.12971012
56MP0002106_abnormal_muscle_physiology1.12809470
57MP0004087_abnormal_muscle_fiber1.12450863
58MP0008569_lethality_at_weaning1.11424305
59MP0001486_abnormal_startle_reflex1.10096510
60MP0009384_cardiac_valve_regurgitation1.10053326
61MP0005377_hearing/vestibular/ear_phenot1.09746717
62MP0003878_abnormal_ear_physiology1.09746717
63MP0003221_abnormal_cardiomyocyte_apopto1.09714649
64MP0004885_abnormal_endolymph1.09266284
65MP0008260_abnormal_autophagy1.09034322
66MP0004859_abnormal_synaptic_plasticity1.08524859
67MP0009250_abnormal_appendicular_skeleto1.04908743
68MP0003121_genomic_imprinting1.02412278
69MP0003879_abnormal_hair_cell1.02125884
70MP0001485_abnormal_pinna_reflex1.01768751
71MP0003123_paternal_imprinting1.01103736
72MP0002272_abnormal_nervous_system1.00191950
73MP0010368_abnormal_lymphatic_system0.99826959
74MP0005248_abnormal_Harderian_gland0.99255878
75MP0003693_abnormal_embryo_hatching0.98985344
76MP0005187_abnormal_penis_morphology0.96826557
77MP0002734_abnormal_mechanical_nocicepti0.94955620
78MP0000566_synostosis0.93943830
79MP0009745_abnormal_behavioral_response0.93334561
80MP0001764_abnormal_homeostasis0.93037149
81MP0008789_abnormal_olfactory_epithelium0.92207911
82MP0002184_abnormal_innervation0.91972646
83MP0005670_abnormal_white_adipose0.91327996
84MP0002067_abnormal_sensory_capabilities0.91027332
85MP0004142_abnormal_muscle_tone0.90809767
86MP0002332_abnormal_exercise_endurance0.90310239
87MP0006138_congestive_heart_failure0.90274721
88MP0002210_abnormal_sex_determination0.90116209
89MP0005369_muscle_phenotype0.90110868
90MP0001968_abnormal_touch/_nociception0.89945016
91MP0002971_abnormal_brown_adipose0.89912798
92MP0000534_abnormal_ureter_morphology0.89891016
93MP0003045_fibrosis0.89711188
94MP0003635_abnormal_synaptic_transmissio0.89559600
95MP0002234_abnormal_pharynx_morphology0.88359902
96MP0000230_abnormal_systemic_arterial0.88325955
97MP0002064_seizures0.88299660
98MP0009046_muscle_twitch0.86718297
99MP0005394_taste/olfaction_phenotype0.84490520
100MP0005499_abnormal_olfactory_system0.84490520
101MP0001440_abnormal_grooming_behavior0.84442348
102MP0002161_abnormal_fertility/fecundity0.83473457
103MP0003279_aneurysm0.83116483
104MP0001970_abnormal_pain_threshold0.80565957
105MP0010630_abnormal_cardiac_muscle0.78860725
106MP0005646_abnormal_pituitary_gland0.78212149
107MP0002733_abnormal_thermal_nociception0.77758056
108MP0003828_pulmonary_edema0.77756334
109MP0000653_abnormal_sex_gland0.77623957
110MP0004484_altered_response_of0.77254899
111MP0000631_abnormal_neuroendocrine_gland0.77127813
112MP0000750_abnormal_muscle_regeneration0.77107801
113MP0006276_abnormal_autonomic_nervous0.75745002
114MP0001963_abnormal_hearing_physiology0.75493395
115MP0003699_abnormal_female_reproductive0.74903406
116MP0000266_abnormal_heart_morphology0.74133565
117MP0008058_abnormal_DNA_repair0.73259089
118MP0001544_abnormal_cardiovascular_syste0.73043318
119MP0005385_cardiovascular_system_phenoty0.73043318
120MP0008007_abnormal_cellular_replicative0.72923097
121MP0004134_abnormal_chest_morphology0.72373656
122MP0000013_abnormal_adipose_tissue0.71514245
123MP0001905_abnormal_dopamine_level0.70586268
124MP0000026_abnormal_inner_ear0.70515062
125MP0000778_abnormal_nervous_system0.69824444
126MP0002128_abnormal_blood_circulation0.69000176
127MP0003656_abnormal_erythrocyte_physiolo0.68461584
128MP0002736_abnormal_nociception_after0.68215096
129MP0004270_analgesia0.67686714
130MP0000759_abnormal_skeletal_muscle0.67481895
131MP0003315_abnormal_perineum_morphology0.67034573
132MP0002063_abnormal_learning/memory/cond0.66439575
133MP0003567_abnormal_fetal_cardiomyocyte0.65735102
134MP0003787_abnormal_imprinting0.65642568
135MP0002572_abnormal_emotion/affect_behav0.63807458
136MP0005266_abnormal_metabolism0.63104392
137MP0005666_abnormal_adipose_tissue0.62179542
138MP0003959_abnormal_lean_body0.59177558
139MP0001346_abnormal_lacrimal_gland0.59131353
140MP0006036_abnormal_mitochondrial_physio0.57672624
141MP0004272_abnormal_basement_membrane0.57539516
142MP0005595_abnormal_vascular_smooth0.56623462
143MP0004924_abnormal_behavior0.56092894
144MP0005386_behavior/neurological_phenoty0.56092894
145MP0000003_abnormal_adipose_tissue0.54162666
146MP0005375_adipose_tissue_phenotype0.53628506
147MP0005503_abnormal_tendon_morphology0.52626133
148MP0002876_abnormal_thyroid_physiology0.51133876
149MP0000767_abnormal_smooth_muscle0.51090111
150MP0002066_abnormal_motor_capabilities/c0.49156386

Predicted human phenotypes

RankGene SetZ-score
1Bony spicule pigmentary retinopathy (HP:0007737)8.31638573
2Muscle fiber inclusion bodies (HP:0100299)7.98586115
3Nemaline bodies (HP:0003798)7.92452457
4Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)7.85112299
5Abnormal rod and cone electroretinograms (HP:0008323)7.16146626
6Type 1 muscle fiber predominance (HP:0003803)6.94540451
7Chorioretinal atrophy (HP:0000533)6.69869862
8Absent rod-and cone-mediated responses on ERG (HP:0007688)6.41980377
9Central scotoma (HP:0000603)6.17438990
10Pigmentary retinal degeneration (HP:0001146)6.16764899
11Pendular nystagmus (HP:0012043)5.97537274
12Abnormality of macular pigmentation (HP:0008002)5.71528101
13Attenuation of retinal blood vessels (HP:0007843)5.49793505
14Scotoma (HP:0000575)5.27383028
15Hyporeflexia of lower limbs (HP:0002600)4.82400905
16EMG: myopathic abnormalities (HP:0003458)4.51258142
17Decreased central vision (HP:0007663)4.47352379
18Abolished electroretinogram (ERG) (HP:0000550)4.12667577
19Dyschromatopsia (HP:0007641)4.09831137
20Type II diabetes mellitus (HP:0005978)4.05171373
21Photophobia (HP:0000613)3.73975820
22Centrally nucleated skeletal muscle fibers (HP:0003687)3.67847669
23Neck muscle weakness (HP:0000467)3.64375731
24Asymmetric septal hypertrophy (HP:0001670)3.63126764
25Distal arthrogryposis (HP:0005684)3.60155417
26Abnormality of skeletal muscle fiber size (HP:0012084)3.54355753
27Severe visual impairment (HP:0001141)3.48043699
28Myotonia (HP:0002486)3.43542631
29Myopathic facies (HP:0002058)3.30591204
30Retinitis pigmentosa (HP:0000510)3.27672457
31Increased variability in muscle fiber diameter (HP:0003557)3.26694109
32Rhabdomyolysis (HP:0003201)3.21758274
33Distal lower limb muscle weakness (HP:0009053)3.16162851
34Increased corneal curvature (HP:0100692)3.15309454
35Keratoconus (HP:0000563)3.15309454
36Choroideremia (HP:0001139)3.14701435
37Dilated cardiomyopathy (HP:0001644)3.13946652
38Difficulty running (HP:0009046)3.08993202
39Increased connective tissue (HP:0009025)3.08619897
40Round ear (HP:0100830)3.05768043
41Vitreoretinal degeneration (HP:0000655)3.05113632
42EMG: neuropathic changes (HP:0003445)2.99026485
43Absent phalangeal crease (HP:0006109)2.96942073
44Areflexia of lower limbs (HP:0002522)2.94192545
45Cone-rod dystrophy (HP:0000548)2.92818551
46Posterior subcapsular cataract (HP:0007787)2.91515206
47Exercise-induced myalgia (HP:0003738)2.78914690
48Macular degeneration (HP:0000608)2.76655125
49Constricted visual fields (HP:0001133)2.76222786
50Hip contracture (HP:0003273)2.75905745
51Slender build (HP:0001533)2.69168722
52Ulnar deviation of the wrist (HP:0003049)2.66087841
53Ventricular fibrillation (HP:0001663)2.57515088
54Frequent falls (HP:0002359)2.52133228
55Sudden death (HP:0001699)2.51079174
56Muscle stiffness (HP:0003552)2.48394932
57Atrial fibrillation (HP:0005110)2.48352575
58Gait imbalance (HP:0002141)2.46039910
59Decreased electroretinogram (ERG) amplitude (HP:0000654)2.45826099
60Mildly elevated creatine phosphokinase (HP:0008180)2.45776964
61Calcaneovalgus deformity (HP:0001848)2.45716428
62Bundle branch block (HP:0011710)2.40335376
63Papillary thyroid carcinoma (HP:0002895)2.40060557
64Congenital primary aphakia (HP:0007707)2.38788166
65Pancreatic fibrosis (HP:0100732)2.38177690
66Left ventricular hypertrophy (HP:0001712)2.37116857
67Spinal rigidity (HP:0003306)2.36271965
68Exercise-induced muscle cramps (HP:0003710)2.35467045
69True hermaphroditism (HP:0010459)2.35347814
70Abnormal finger flexion creases (HP:0006143)2.35346803
71Syncope (HP:0001279)2.34208870
72Abnormality of the ischium (HP:0003174)2.34061687
73Generalized muscle weakness (HP:0003324)2.31401975
74Prolonged QT interval (HP:0001657)2.30281959
75Hyperkalemia (HP:0002153)2.28879280
76Hypoplastic ischia (HP:0003175)2.28290937
77Male infertility (HP:0003251)2.28064876
78Primary atrial arrhythmia (HP:0001692)2.27181079
79Medial flaring of the eyebrow (HP:0010747)2.21982204
80Nephrogenic diabetes insipidus (HP:0009806)2.20595764
81Deformed tarsal bones (HP:0008119)2.19420084
82Fetal akinesia sequence (HP:0001989)2.19274428
83Poor coordination (HP:0002370)2.17130762
84Limited hip movement (HP:0008800)2.17088745
85Muscular dystrophy (HP:0003560)2.16650198
86Supraventricular tachycardia (HP:0004755)2.13323808
87Distal lower limb amyotrophy (HP:0008944)2.10311506
88Scapular winging (HP:0003691)2.09863546
89Congenital sensorineural hearing impairment (HP:0008527)2.08184590
90Supraventricular arrhythmia (HP:0005115)2.04421397
91Hypoplasia of the fovea (HP:0007750)2.03680571
92Aplasia/Hypoplasia of the fovea (HP:0008060)2.03680571
93Steppage gait (HP:0003376)2.02408262
94Calf muscle hypertrophy (HP:0008981)2.02009475
95Congenital stationary night blindness (HP:0007642)11.6456167
96Oligodactyly (hands) (HP:0001180)1.99778935
97Progressive cerebellar ataxia (HP:0002073)1.99418727
98Optic disc pallor (HP:0000543)1.97605900
99Bradycardia (HP:0001662)1.97280356
100Abnormality of the fovea (HP:0000493)1.97109025
101Weak cry (HP:0001612)1.94925941
102Malignant hyperthermia (HP:0002047)1.91391954
103Abnormality of the foot musculature (HP:0001436)1.91199890
104Abnormal EKG (HP:0003115)1.91089089
105Abnormality of the calf musculature (HP:0001430)1.89971494
106Gowers sign (HP:0003391)1.88956131
107Subcapsular cataract (HP:0000523)1.88692821
108Genital tract atresia (HP:0001827)1.87823530
109Wide nasal bridge (HP:0000431)1.87475549
110Abnormality of midbrain morphology (HP:0002418)1.86422867
111Molar tooth sign on MRI (HP:0002419)1.86422867
112Vaginal atresia (HP:0000148)1.86166879
113Hypoplastic heart (HP:0001961)1.85147883
114Lower limb amyotrophy (HP:0007210)1.83149987
115Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.80374862
116Abnormality of the shoulder girdle musculature (HP:0001435)1.79494792
117Myoglobinuria (HP:0002913)1.77955353
118Difficulty climbing stairs (HP:0003551)1.77766820
119Muscle hypertrophy of the lower extremities (HP:0008968)1.77186862
120Hypoplastic left heart (HP:0004383)1.76565486
121Oligodactyly (HP:0012165)1.75682180
122Ventricular tachycardia (HP:0004756)1.74152619
123Progressive visual loss (HP:0000529)1.71727282
124Foot dorsiflexor weakness (HP:0009027)1.70337124
125Febrile seizures (HP:0002373)1.70056955
126Bulbar palsy (HP:0001283)1.69553148
127Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.69396041
128Ventricular arrhythmia (HP:0004308)1.68199969
129Heart block (HP:0012722)1.67296289
130Pancreatic cysts (HP:0001737)1.66532565
131Limb-girdle muscle atrophy (HP:0003797)1.65519278
132Limb-girdle muscle weakness (HP:0003325)1.64471076
133Retinal atrophy (HP:0001105)1.63089092
134Genetic anticipation (HP:0003743)1.59845646
135Nephronophthisis (HP:0000090)1.59121827
136Waddling gait (HP:0002515)1.57286438
137Muscle fiber splitting (HP:0003555)1.57046952
138Dysdiadochokinesis (HP:0002075)1.56984207
139Atrioventricular block (HP:0001678)1.56185545
140Tinnitus (HP:0000360)1.55262409
141Lipoatrophy (HP:0100578)1.54064673
142Diaphragmatic weakness (HP:0009113)1.53867974
143Facial diplegia (HP:0001349)1.53324083
144Focal motor seizures (HP:0011153)1.52716630
145Hemiplegia (HP:0002301)1.51129630
146Abnormality of the left ventricular outflow tract (HP:0011103)1.49562194
147Subaortic stenosis (HP:0001682)1.49562194
148Anterior segment dysgenesis (HP:0007700)1.49367710
149Epileptic encephalopathy (HP:0200134)1.49199376
150Right ventricular cardiomyopathy (HP:0011663)1.48911124
151Septo-optic dysplasia (HP:0100842)1.47369626
152Abnormality of the lower motor neuron (HP:0002366)1.47059790
153Palpitations (HP:0001962)1.46955429
154Abnormality of the neuromuscular junction (HP:0003398)1.46829570
155Fatigable weakness (HP:0003473)1.46829570
156Severe Myopia (HP:0011003)1.46823084
157Congenital malformation of the right heart (HP:0011723)1.46108841
158Double outlet right ventricle (HP:0001719)1.46108841
159Proximal amyotrophy (HP:0007126)1.45948990
160Patellar aplasia (HP:0006443)1.45244241
161Dysmetric saccades (HP:0000641)1.44000872
162Abnormal atrioventricular conduction (HP:0005150)1.43275820
163Chorioretinal coloboma (HP:0000567)1.42699586
164Insulin-resistant diabetes mellitus (HP:0000831)1.42262846
165Cystic liver disease (HP:0006706)1.39430685
166Protrusio acetabuli (HP:0003179)1.39243615
167Aplasia/Hypoplasia of the lens (HP:0008063)1.37654236
168Broad foot (HP:0001769)1.36924495
169Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.35861593
170Aplasia/Hypoplasia of the tongue (HP:0010295)1.35019334
171Rimmed vacuoles (HP:0003805)1.33928715
172Aplasia/Hypoplasia of the macula (HP:0008059)1.33428635

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN4.51690219
2STK38L3.92223983
3OBSCN3.62018017
4LATS13.49111908
5PRKD32.99874269
6FRK2.78611156
7GRK12.63169065
8PHKG12.51530924
9PHKG22.51530924
10PINK12.40776888
11LATS22.28541955
12STK382.23212430
13PBK2.04237127
14PLK42.02671209
15PDK41.98062860
16PDK31.98062860
17PIK3CG1.87230508
18STK241.86291645
19MAP3K41.79681137
20NEK11.73715066
21NEK21.68434267
22MAPK131.60474557
23TTK1.58676431
24NEK91.53702906
25PRKAA11.53642731
26MARK11.52509004
27MUSK1.48841968
28CDK31.45890587
29CASK1.45789881
30STK31.42660684
31MAPK121.41610935
32SRPK11.41125922
33IRAK21.40466183
34CCNB11.36212449
35TRPM71.33225254
36SGK21.32657624
37PAK61.32376729
38MAP3K61.27553596
39AKT31.26244539
40PLK31.25151202
41MOS1.24959771
42CHEK21.23921655
43MAP3K71.23887826
44INSRR1.22771800
45ROCK11.19306825
46PKN21.16664540
47LIMK11.15977501
48NTRK31.15181243
49TNIK1.14918784
50MAP2K71.12710410
51DYRK1A1.11933858
52DDR21.11865056
53LMTK21.09420446
54SGK4941.07734043
55SGK2231.07734043
56GRK71.07187992
57CAMK2G1.06365762
58PLK11.05988612
59PDK20.97000183
60WNK30.96870786
61NTRK20.95368938
62ZAK0.94035679
63PTK2B0.92872375
64MAPKAPK30.91413268
65ERBB40.89368098
66NUAK10.86247146
67PRKAA20.85601359
68SGK30.84263417
69BUB10.83143382
70ICK0.83136023
71PKN10.82684349
72BRAF0.82132872
73MKNK20.81712063
74WNK10.80552788
75CAMK40.79294030
76MAP2K10.77273948
77BRSK20.76235384
78ROCK20.76221819
79CAMK2B0.75222362
80MAPK110.73054479
81DMPK0.72841379
82BRSK10.67193028
83PRKD10.65827913
84ADRBK10.64440421
85PRKCG0.64331920
86MAP2K40.63588965
87UHMK10.61777927
88PDGFRA0.61297879
89PRKD20.61110304
90MYLK0.61071729
91CDC42BPA0.60066827
92TAOK10.59379631
93PRKCZ0.59190603
94TAOK30.59171146
95NTRK10.58949453
96CHEK10.58107674
97PNCK0.56869876
98ADRBK20.56026950
99MAPK70.55724505
100CAMK1G0.54137441
101PAK30.53890856
102CDK10.53686061
103CDK80.53435638
104DYRK20.52548491
105RPS6KA30.52313147
106MAPK40.50125362
107CAMK2A0.49208020
108PTK20.48206336
109MAP3K90.47715098
110KSR10.47452457
111GSK3B0.46663366
112CSNK1D0.45262763
113ATM0.45121437
114TIE10.44982089
115CAMK1D0.44686939
116CDC70.44134007
117RIPK10.43853312
118MARK30.43377192
119BLK0.42723248
120MINK10.42718318
121PRKACA0.42706434
122PRKCE0.42561242
123AURKB0.42083196
124DYRK1B0.42070454
125MTOR0.41449780
126PRKG10.41439407
127MAP3K50.40692861
128AURKA0.39709196
129PRKACB0.38946528
130CAMK2D0.38849824
131SGK10.38654418
132PLK20.38387433
133PRPF4B0.37795787
134MAPK100.37446843
135CDK20.37411305
136PRKACG0.37315517
137CDK50.35041504
138STK390.35014966
139BRD40.34677180
140EEF2K0.34293990
141AKT20.34213995
142RPS6KA20.33568208
143EPHA40.33377716
144PIK3CA0.33167946
145PDK10.32464977
146CSNK1E0.32110594
147CAMK10.30472874
148KSR20.30258725
149MET0.29184667
150RPS6KA60.25561206

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007502.35328268
2Circadian rhythm_Homo sapiens_hsa047102.30363347
3Cardiac muscle contraction_Homo sapiens_hsa042602.15850518
4Phototransduction_Homo sapiens_hsa0474410.4440237
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.70396116
6Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.67929638
7Nicotine addiction_Homo sapiens_hsa050331.64865317
8Olfactory transduction_Homo sapiens_hsa047401.63452750
9Dilated cardiomyopathy_Homo sapiens_hsa054141.61014213
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.53292639
11Synaptic vesicle cycle_Homo sapiens_hsa047211.50585596
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.47753203
13GABAergic synapse_Homo sapiens_hsa047271.46999568
14Focal adhesion_Homo sapiens_hsa045101.35512334
15Insulin secretion_Homo sapiens_hsa049111.32810856
16Renin secretion_Homo sapiens_hsa049241.30832853
17Oocyte meiosis_Homo sapiens_hsa041141.29480474
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.28791485
19Circadian entrainment_Homo sapiens_hsa047131.27993187
20Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.26164370
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.25353314
22Glutamatergic synapse_Homo sapiens_hsa047241.24516471
23ECM-receptor interaction_Homo sapiens_hsa045121.23091642
24Basal transcription factors_Homo sapiens_hsa030221.21798408
25Fructose and mannose metabolism_Homo sapiens_hsa000511.20331499
26Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.18557541
27RNA degradation_Homo sapiens_hsa030181.17839503
28Morphine addiction_Homo sapiens_hsa050321.13089929
29Biosynthesis of amino acids_Homo sapiens_hsa012301.08136305
30Butanoate metabolism_Homo sapiens_hsa006501.06551064
31Cell cycle_Homo sapiens_hsa041101.04107765
32Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.04072482
33Glucagon signaling pathway_Homo sapiens_hsa049221.03367803
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.03052537
35Regulation of autophagy_Homo sapiens_hsa041401.02325579
36Regulation of actin cytoskeleton_Homo sapiens_hsa048101.01653847
37Cholinergic synapse_Homo sapiens_hsa047251.01459929
38cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00081582
39Purine metabolism_Homo sapiens_hsa002301.00029303
40Gap junction_Homo sapiens_hsa045400.99433284
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.96455619
42Dopaminergic synapse_Homo sapiens_hsa047280.93965626
43Glycerophospholipid metabolism_Homo sapiens_hsa005640.89142823
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.87049287
45Carbon metabolism_Homo sapiens_hsa012000.86292771
46Fatty acid biosynthesis_Homo sapiens_hsa000610.85936309
47Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.82167322
48Pentose phosphate pathway_Homo sapiens_hsa000300.81852395
49Glioma_Homo sapiens_hsa052140.81086354
50Ovarian steroidogenesis_Homo sapiens_hsa049130.80521932
51mRNA surveillance pathway_Homo sapiens_hsa030150.79643148
52Melanoma_Homo sapiens_hsa052180.79435123
53Aldosterone synthesis and secretion_Homo sapiens_hsa049250.77958823
54Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77603538
55PPAR signaling pathway_Homo sapiens_hsa033200.77135207
56Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.76755804
57Adherens junction_Homo sapiens_hsa045200.76188864
58RNA transport_Homo sapiens_hsa030130.75022697
59Oxytocin signaling pathway_Homo sapiens_hsa049210.74566216
60Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74540013
61RNA polymerase_Homo sapiens_hsa030200.74419688
62Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.74391685
63Longevity regulating pathway - mammal_Homo sapiens_hsa042110.74155463
64Pyruvate metabolism_Homo sapiens_hsa006200.74024102
65Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.72316176
66Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.71617214
67Amphetamine addiction_Homo sapiens_hsa050310.71214431
68Taste transduction_Homo sapiens_hsa047420.70894730
69Serotonergic synapse_Homo sapiens_hsa047260.69787897
70cAMP signaling pathway_Homo sapiens_hsa040240.68911202
71Pancreatic secretion_Homo sapiens_hsa049720.67841304
72Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.67240451
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.67148856
74Long-term potentiation_Homo sapiens_hsa047200.65770251
75Type II diabetes mellitus_Homo sapiens_hsa049300.65442399
76MAPK signaling pathway_Homo sapiens_hsa040100.64760046
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.64724606
78Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64120803
79mTOR signaling pathway_Homo sapiens_hsa041500.63754234
80Fanconi anemia pathway_Homo sapiens_hsa034600.63592850
81Calcium signaling pathway_Homo sapiens_hsa040200.63430773
82Bile secretion_Homo sapiens_hsa049760.62094822
83Central carbon metabolism in cancer_Homo sapiens_hsa052300.59396246
84AMPK signaling pathway_Homo sapiens_hsa041520.59122167
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57936484
86Platelet activation_Homo sapiens_hsa046110.57844308
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.57814599
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55838803
89Linoleic acid metabolism_Homo sapiens_hsa005910.55587878
90Inositol phosphate metabolism_Homo sapiens_hsa005620.55418734
91Cysteine and methionine metabolism_Homo sapiens_hsa002700.54606979
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53713358
93Estrogen signaling pathway_Homo sapiens_hsa049150.53496073
94Dorso-ventral axis formation_Homo sapiens_hsa043200.52867473
95Alzheimers disease_Homo sapiens_hsa050100.52740104
96Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.52302029
97Propanoate metabolism_Homo sapiens_hsa006400.50494901
98Fatty acid metabolism_Homo sapiens_hsa012120.50472843
99Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50413538
100Hedgehog signaling pathway_Homo sapiens_hsa043400.50197401
101Huntingtons disease_Homo sapiens_hsa050160.49309576
102Proteoglycans in cancer_Homo sapiens_hsa052050.49131610
103Nitrogen metabolism_Homo sapiens_hsa009100.48098939
104Hippo signaling pathway_Homo sapiens_hsa043900.47525785
105Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.47135629
106Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.47007590
107Lysine degradation_Homo sapiens_hsa003100.46066384
108Protein digestion and absorption_Homo sapiens_hsa049740.44545312
109Galactose metabolism_Homo sapiens_hsa000520.43807136
110Vascular smooth muscle contraction_Homo sapiens_hsa042700.43769516
111Melanogenesis_Homo sapiens_hsa049160.42661182
112Tight junction_Homo sapiens_hsa045300.42600323
113Tryptophan metabolism_Homo sapiens_hsa003800.42045904
114Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.41022898
115HIF-1 signaling pathway_Homo sapiens_hsa040660.40824020
116Insulin signaling pathway_Homo sapiens_hsa049100.40703714
117Arginine and proline metabolism_Homo sapiens_hsa003300.40381833
118Mineral absorption_Homo sapiens_hsa049780.40120489
119GnRH signaling pathway_Homo sapiens_hsa049120.39905336
120Ras signaling pathway_Homo sapiens_hsa040140.38701440
121Salivary secretion_Homo sapiens_hsa049700.37859311
122Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.37815185
123Arginine biosynthesis_Homo sapiens_hsa002200.37613807
124Starch and sucrose metabolism_Homo sapiens_hsa005000.37459401
125Choline metabolism in cancer_Homo sapiens_hsa052310.36964723
126Endometrial cancer_Homo sapiens_hsa052130.36716244
127Maturity onset diabetes of the young_Homo sapiens_hsa049500.36673956
128Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.35649547
129Insulin resistance_Homo sapiens_hsa049310.35538934
130Cocaine addiction_Homo sapiens_hsa050300.34765732
131Fatty acid degradation_Homo sapiens_hsa000710.34718738
132Long-term depression_Homo sapiens_hsa047300.33855154
133Glycerolipid metabolism_Homo sapiens_hsa005610.33399995
134Gastric acid secretion_Homo sapiens_hsa049710.33094691

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