DPH2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is one of two human genes similar to the yeast gene dph2. The yeast gene was identified by its ability to complement a diphthamide mutant strain, and thus probably functions in diphthamide biosynthesis. Diphthamide is a post-translationally modified histidine residue present in elongation factor 2 (EF2) that is the target of diphtheria toxin ADP-ribosylation. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.29339652
2DNA strand elongation involved in DNA replication (GO:0006271)5.11797251
3DNA strand elongation (GO:0022616)4.87719546
4peptidyl-arginine omega-N-methylation (GO:0035247)4.80671332
5telomere maintenance via semi-conservative replication (GO:0032201)4.73292989
6histone arginine methylation (GO:0034969)4.44489901
7purine nucleobase biosynthetic process (GO:0009113)4.43265951
8telomere maintenance via recombination (GO:0000722)4.42900554
9DNA deamination (GO:0045006)4.37472058
10nucleobase biosynthetic process (GO:0046112)4.32808801
11maturation of SSU-rRNA (GO:0030490)4.28744877
12ribosome assembly (GO:0042255)4.22477951
13proteasome assembly (GO:0043248)4.21926057
14DNA replication initiation (GO:0006270)4.19234425
15formation of translation preinitiation complex (GO:0001731)4.14825169
16transcription from mitochondrial promoter (GO:0006390)4.12627007
17DNA unwinding involved in DNA replication (GO:0006268)4.12412337
18viral transcription (GO:0019083)4.08417473
19mitotic recombination (GO:0006312)4.02316498
20translational termination (GO:0006415)4.01804993
21ribosomal small subunit biogenesis (GO:0042274)4.01324058
22peptidyl-arginine methylation (GO:0018216)3.98602255
23peptidyl-arginine N-methylation (GO:0035246)3.98602255
24ribosome biogenesis (GO:0042254)3.97505255
25telomere maintenance via telomere lengthening (GO:0010833)3.95575452
26ribonucleoprotein complex biogenesis (GO:0022613)3.89444266
27tRNA methylation (GO:0030488)3.80662515
28establishment of integrated proviral latency (GO:0075713)3.80508105
29mitochondrial RNA metabolic process (GO:0000959)3.75241256
30ribosomal large subunit biogenesis (GO:0042273)3.74069609
31regulation of mitochondrial translation (GO:0070129)3.72467531
32regulation of translational termination (GO:0006449)3.67256707
33proline biosynthetic process (GO:0006561)3.66144310
34rRNA processing (GO:0006364)3.65012601
35translational initiation (GO:0006413)3.64747568
36nucleotide-excision repair, DNA gap filling (GO:0006297)3.64098169
37CENP-A containing nucleosome assembly (GO:0034080)3.61488309
38pseudouridine synthesis (GO:0001522)3.60901580
39regulation of translational fidelity (GO:0006450)3.60841953
40rRNA transcription (GO:0009303)3.60600400
41translational elongation (GO:0006414)3.60411500
42regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.55287046
43IMP biosynthetic process (GO:0006188)3.52083028
44rRNA metabolic process (GO:0016072)3.51263304
45spliceosomal tri-snRNP complex assembly (GO:0000244)3.50960511
46oxidative phosphorylation (GO:0006119)3.50893335
47chromatin remodeling at centromere (GO:0031055)3.50732125
48rRNA modification (GO:0000154)3.47976595
49DNA replication checkpoint (GO:0000076)3.47162845
50mitotic metaphase plate congression (GO:0007080)3.43220250
51SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.41004315
52spliceosomal snRNP assembly (GO:0000387)3.40864829
53negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.35235953
54DNA replication-independent nucleosome organization (GO:0034724)3.33033194
55DNA replication-independent nucleosome assembly (GO:0006336)3.33033194
56nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.32703394
57cotranslational protein targeting to membrane (GO:0006613)3.32393145
58maturation of 5.8S rRNA (GO:0000460)3.31358051
59protein targeting to ER (GO:0045047)3.30039283
60L-serine metabolic process (GO:0006563)3.29686355
61protein targeting to mitochondrion (GO:0006626)3.29653970
62tRNA aminoacylation for protein translation (GO:0006418)3.29350281
63transcription-coupled nucleotide-excision repair (GO:0006283)3.29150803
64cellular protein complex disassembly (GO:0043624)3.25020951
65DNA replication-dependent nucleosome organization (GO:0034723)3.23731094
66DNA replication-dependent nucleosome assembly (GO:0006335)3.23731094
67protein complex localization (GO:0031503)3.23203846
68amino acid activation (GO:0043038)3.21127319
69tRNA aminoacylation (GO:0043039)3.21127319
70viral life cycle (GO:0019058)3.19916119
71pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.18216965
72protein localization to kinetochore (GO:0034501)3.16427941
73nucleobase-containing small molecule interconversion (GO:0015949)3.14754504
74telomere maintenance (GO:0000723)3.14705983
75establishment of protein localization to endoplasmic reticulum (GO:0072599)3.11185276
76telomere organization (GO:0032200)3.10815137
77mitotic nuclear envelope disassembly (GO:0007077)3.10721966
78folic acid transport (GO:0015884)3.10327290
79negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.09330385
80establishment of viral latency (GO:0019043)3.08375054
81attachment of spindle microtubules to kinetochore (GO:0008608)3.07485426
82protein maturation by protein folding (GO:0022417)3.07480664
83protein localization to endoplasmic reticulum (GO:0070972)3.07138650
84positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.06594415
85regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.05964809
86cellular component biogenesis (GO:0044085)3.05546590
87nuclear pore complex assembly (GO:0051292)3.03722724
88pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.02618688
89protein localization to chromosome, centromeric region (GO:0071459)3.02538468
90termination of RNA polymerase I transcription (GO:0006363)3.02409049
91base-excision repair (GO:0006284)3.01217065
92anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.00327323
93heterochromatin organization (GO:0070828)2.98616548
94establishment of protein localization to mitochondrion (GO:0072655)2.98384417
95rRNA methylation (GO:0031167)2.98154360
96positive regulation of chromosome segregation (GO:0051984)2.96863632
97deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.96688560
98snRNA processing (GO:0016180)2.96036394
99translation (GO:0006412)2.95109507
100cellular protein complex localization (GO:0034629)2.94330114
101transcription elongation from RNA polymerase I promoter (GO:0006362)2.94179427
102snRNA metabolic process (GO:0016073)2.94028383
103mitotic sister chromatid segregation (GO:0000070)2.93350046
104ncRNA processing (GO:0034470)2.92935589
105protein complex disassembly (GO:0043241)2.92833023
106negative regulation of mRNA processing (GO:0050686)2.89106718
1077-methylguanosine mRNA capping (GO:0006370)2.88316554
108viral mRNA export from host cell nucleus (GO:0046784)2.87722140
109pentose metabolic process (GO:0019321)2.87642993
110mitotic chromosome condensation (GO:0007076)2.87486348
111negative regulation of RNA splicing (GO:0033119)2.86935269
112tRNA modification (GO:0006400)2.86637903
113pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.86520143
114transcription elongation from RNA polymerase III promoter (GO:0006385)2.85647432
115termination of RNA polymerase III transcription (GO:0006386)2.85647432
116protein localization to mitochondrion (GO:0070585)2.85242823
117establishment of protein localization to mitochondrial membrane (GO:0090151)2.85149445
118IMP metabolic process (GO:0046040)2.84483531
1197-methylguanosine RNA capping (GO:0009452)2.84463274
120RNA capping (GO:0036260)2.84463274
121pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.83779295
122negative regulation of ligase activity (GO:0051352)2.82929807
123negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.82929807
124nuclear-transcribed mRNA catabolic process (GO:0000956)2.81600651
125L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.81463979
126folic acid-containing compound biosynthetic process (GO:0009396)2.81369435
127pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.79574002
128guanosine-containing compound biosynthetic process (GO:1901070)2.79222945
129base-excision repair, AP site formation (GO:0006285)2.78950036
130ncRNA metabolic process (GO:0034660)2.77339955
131nuclear pore organization (GO:0006999)2.76702138
132G1/S transition of mitotic cell cycle (GO:0000082)2.76467767
133cell cycle G1/S phase transition (GO:0044843)2.76467767
134macromolecular complex disassembly (GO:0032984)2.76457946
135histone mRNA metabolic process (GO:0008334)2.75871875
136mRNA splicing, via spliceosome (GO:0000398)2.75475631
137RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.75475631
138metaphase plate congression (GO:0051310)2.75463001
139nuclear envelope disassembly (GO:0051081)2.75336545
140membrane disassembly (GO:0030397)2.75336545
141transcription from RNA polymerase I promoter (GO:0006360)2.75072536
142ncRNA 3-end processing (GO:0043628)2.74988901
143mitotic G2 DNA damage checkpoint (GO:0007095)2.74957922
144mismatch repair (GO:0006298)2.74924683
145iron-sulfur cluster assembly (GO:0016226)2.74726380
146metallo-sulfur cluster assembly (GO:0031163)2.74726380
147UTP biosynthetic process (GO:0006228)2.74693523
148negative regulation of mRNA metabolic process (GO:1903312)2.72704464

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.45354057
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.27012821
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.62421450
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.50742804
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.45758794
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.31014921
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.15793191
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.09523884
9* ETS1_20019798_ChIP-Seq_JURKAT_Human3.04455245
10* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.03565126
11* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.91187499
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.85182860
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.76552835
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.72623485
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.71143586
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.65644654
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.56931382
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.45956399
19XRN2_22483619_ChIP-Seq_HELA_Human2.42761909
20VDR_23849224_ChIP-Seq_CD4+_Human2.32100711
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.28293689
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.24103874
23FOXP3_21729870_ChIP-Seq_TREG_Human2.22259138
24* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.11728307
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.08859159
26* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.08691110
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.05832251
28DCP1A_22483619_ChIP-Seq_HELA_Human2.03527772
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.99491360
30THAP11_20581084_ChIP-Seq_MESCs_Mouse1.96453358
31E2F1_18555785_ChIP-Seq_MESCs_Mouse1.94294841
32TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.87546618
33NOTCH1_21737748_ChIP-Seq_TLL_Human1.86760549
34SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.86147635
35AR_21909140_ChIP-Seq_LNCAP_Human1.85081338
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.83770717
37TTF2_22483619_ChIP-Seq_HELA_Human1.83433178
38MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.78908001
39* GABP_19822575_ChIP-Seq_HepG2_Human1.78841955
40E2F1_21310950_ChIP-Seq_MCF-7_Human1.73564918
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73157580
42MYC_22102868_ChIP-Seq_BL_Human1.73153650
43MYCN_18555785_ChIP-Seq_MESCs_Mouse1.72112609
44SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.70420193
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.67916540
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.67639204
47YY1_21170310_ChIP-Seq_MESCs_Mouse1.64443911
48FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.62632275
49PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.58874966
50VDR_21846776_ChIP-Seq_THP-1_Human1.58236799
51ERG_20887958_ChIP-Seq_HPC-7_Mouse1.57872886
52YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.57163854
53EGR1_19374776_ChIP-ChIP_THP-1_Human1.55063261
54ELK1_19687146_ChIP-ChIP_HELA_Human1.54208358
55CIITA_25753668_ChIP-Seq_RAJI_Human1.53823508
56ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.52879881
57SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.51272606
58* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46239832
59ZNF263_19887448_ChIP-Seq_K562_Human1.46071137
60NANOG_18555785_ChIP-Seq_MESCs_Mouse1.44221463
61ZFX_18555785_ChIP-Seq_MESCs_Mouse1.43412008
62SRF_21415370_ChIP-Seq_HL-1_Mouse1.41757928
63* KDM5A_27292631_Chip-Seq_BREAST_Human1.37394317
64IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.36192154
65PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.34112077
66CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.33788138
67MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.30903333
68ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.29995549
69CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.29951293
70SPI1_23547873_ChIP-Seq_NB4_Human1.25899875
71CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.23799931
72KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.22152918
73* TET1_21451524_ChIP-Seq_MESCs_Mouse1.19218085
74KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.14998012
75E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13933939
76GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.10500080
77HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.09322668
78POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08774335
79* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.07855374
80CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.06840716
81TFEB_21752829_ChIP-Seq_HELA_Human1.05758460
82SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.05261494
83DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.03996315
84KLF4_18555785_ChIP-Seq_MESCs_Mouse1.01549283
85* FOXP1_21924763_ChIP-Seq_HESCs_Human1.01537289
86ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.01298633
87MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.00952787
88DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.97899507
89TBX5_21415370_ChIP-Seq_HL-1_Mouse0.96439727
90MYC_18940864_ChIP-ChIP_HL60_Human0.95521397
91CTCF_18555785_ChIP-Seq_MESCs_Mouse0.94644645
92CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.94570423
93ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93069866
94STAT4_19710469_ChIP-ChIP_TH1__Mouse0.92871197
95ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.92388383
96CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.91763383
97POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.90285581
98CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.90184808
99IRF8_22096565_ChIP-ChIP_GC-B_Human0.89481451
100SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.88958448
101TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88841743
102ELF1_20517297_ChIP-Seq_JURKAT_Human0.88154306
103P68_20966046_ChIP-Seq_HELA_Human0.87107497
104STAT3_1855785_ChIP-Seq_MESCs_Mouse0.87039291
105* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86961896
106BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.86834449
107RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.86805110
108SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.86687178
109NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.85958647
110TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.83756054
111CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.82257343
112CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.81193331
113TP63_19390658_ChIP-ChIP_HaCaT_Human0.80762505
114KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.80419163
115MYB_26560356_Chip-Seq_TH2_Human0.79246878
116RUNX1_22412390_ChIP-Seq_EML_Mouse0.78682393
117SRY_22984422_ChIP-ChIP_TESTIS_Rat0.78593925
118HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.78249606
119SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.77978337

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.75848609
2MP0010094_abnormal_chromosome_stability4.31603284
3MP0003693_abnormal_embryo_hatching4.26750298
4MP0003111_abnormal_nucleus_morphology4.20118189
5MP0003077_abnormal_cell_cycle3.83700183
6MP0002396_abnormal_hematopoietic_system3.54811959
7MP0004957_abnormal_blastocyst_morpholog3.42558456
8MP0008007_abnormal_cellular_replicative3.11327688
9MP0008058_abnormal_DNA_repair3.09222517
10MP0003763_abnormal_thymus_physiology2.75925237
11MP0003806_abnormal_nucleotide_metabolis2.52610905
12MP0008932_abnormal_embryonic_tissue2.44754264
13MP0009333_abnormal_splenocyte_physiolog2.39856237
14MP0006035_abnormal_mitochondrial_morpho2.34127210
15MP0005451_abnormal_body_composition2.29374250
16MP0006036_abnormal_mitochondrial_physio2.21586183
17MP0010352_gastrointestinal_tract_polyps2.19026840
18MP0008260_abnormal_autophagy2.10075733
19MP0004233_abnormal_muscle_weight2.08103924
20MP0008877_abnormal_DNA_methylation2.07637022
21MP0003786_premature_aging2.06407607
22MP0004808_abnormal_hematopoietic_stem1.95162887
23MP0001730_embryonic_growth_arrest1.95103207
24MP0000350_abnormal_cell_proliferation1.93528210
25MP0010307_abnormal_tumor_latency1.91576283
26MP0000490_abnormal_crypts_of1.90858201
27MP0002877_abnormal_melanocyte_morpholog1.88135062
28MP0002398_abnormal_bone_marrow1.82790317
29MP0000685_abnormal_immune_system1.72588358
30MP0005671_abnormal_response_to1.71109123
31MP0000566_synostosis1.69713073
32MP0000703_abnormal_thymus_morphology1.68111600
33MP0003186_abnormal_redox_activity1.66118325
34MP0001661_extended_life_span1.64484479
35MP0004185_abnormal_adipocyte_glucose1.62109456
36MP0001800_abnormal_humoral_immune1.61192659
37MP0000313_abnormal_cell_death1.59463432
38MP0001835_abnormal_antigen_presentation1.59346183
39MP0009672_abnormal_birth_weight1.58666490
40MP0001545_abnormal_hematopoietic_system1.56994287
41MP0005397_hematopoietic_system_phenotyp1.56994287
42MP0000678_abnormal_parathyroid_gland1.56881435
43MP0006292_abnormal_olfactory_placode1.55986415
44MP0000689_abnormal_spleen_morphology1.53886470
45MP0009785_altered_susceptibility_to1.53695992
46MP0002132_abnormal_respiratory_system1.53543090
47MP0005501_abnormal_skin_physiology1.52388067
48MP0003718_maternal_effect1.51553332
49MP0002019_abnormal_tumor_incidence1.50451549
50MP0002722_abnormal_immune_system1.49580724
51MP0003123_paternal_imprinting1.48762794
52MP0003436_decreased_susceptibility_to1.44527880
53MP0002796_impaired_skin_barrier1.43910341
54MP0002429_abnormal_blood_cell1.42388377
55MP0000716_abnormal_immune_system1.41437975
56MP0002420_abnormal_adaptive_immunity1.39973787
57MP0001819_abnormal_immune_cell1.37921188
58MP0002452_abnormal_antigen_presenting1.34552377
59MP0003221_abnormal_cardiomyocyte_apopto1.30666559
60MP0002723_abnormal_immune_serum1.28492801
61MP0001672_abnormal_embryogenesis/_devel1.28005644
62MP0005380_embryogenesis_phenotype1.28005644
63MP0002405_respiratory_system_inflammati1.27687013
64MP0002080_prenatal_lethality1.26959818
65MP0010030_abnormal_orbit_morphology1.26344243
66MP0001697_abnormal_embryo_size1.25516865
67MP0005000_abnormal_immune_tolerance1.23960061
68MP0003315_abnormal_perineum_morphology1.20560928
69MP0010155_abnormal_intestine_physiology1.19478132
70MP0001293_anophthalmia1.18416256
71MP0009278_abnormal_bone_marrow1.16333816
72MP0009697_abnormal_copulation1.15768941
73MP0002148_abnormal_hypersensitivity_rea1.13032408
74MP0003984_embryonic_growth_retardation1.10873518
75MP0000858_altered_metastatic_potential1.09608985
76MP0005025_abnormal_response_to1.09479127
77MP0002102_abnormal_ear_morphology1.07772618
78MP0002088_abnormal_embryonic_growth/wei1.05670903
79MP0000537_abnormal_urethra_morphology1.04859063
80MP0002166_altered_tumor_susceptibility1.02933687
81MP0005330_cardiomyopathy0.95989049
82MP0003941_abnormal_skin_development0.95645129
83MP0005076_abnormal_cell_differentiation0.95330501
84MP0001849_ear_inflammation0.95136570
85MP0000465_gastrointestinal_hemorrhage0.92055693
86MP0002085_abnormal_embryonic_tissue0.90958864
87MP0001873_stomach_inflammation0.90741278
88MP0003866_abnormal_defecation0.90288187
89MP0002006_tumorigenesis0.89695796
90MP0001790_abnormal_immune_system0.88697226
91MP0005387_immune_system_phenotype0.88697226
92MP0002086_abnormal_extraembryonic_tissu0.88565362
93MP0009840_abnormal_foam_cell0.88372318
94MP0002419_abnormal_innate_immunity0.86984192
95MP0001188_hyperpigmentation0.85827577
96MP0002269_muscular_atrophy0.85507123
97MP0002084_abnormal_developmental_patter0.83746099
98MP0001764_abnormal_homeostasis0.83714700
99MP0003121_genomic_imprinting0.83192694
100MP0002210_abnormal_sex_determination0.82704065
101MP0005075_abnormal_melanosome_morpholog0.80973352
102MP0009379_abnormal_foot_pigmentation0.80346671
103MP0000358_abnormal_cell_content/0.79512126
104MP0001881_abnormal_mammary_gland0.78381386
105MP0002234_abnormal_pharynx_morphology0.77398416
106MP0002254_reproductive_system_inflammat0.77000486
107MP0001145_abnormal_male_reproductive0.76564192
108MP0005670_abnormal_white_adipose0.76333733
109MP0005257_abnormal_intraocular_pressure0.75868588
110MP0005423_abnormal_somatic_nervous0.74451074
111MP0005408_hypopigmentation0.74192283
112MP0001346_abnormal_lacrimal_gland0.73283811
113MP0003943_abnormal_hepatobiliary_system0.73077427
114MP0001845_abnormal_inflammatory_respons0.72557620
115MP0000372_irregular_coat_pigmentation0.72528850
116MP0002163_abnormal_gland_morphology0.72274013
117MP0002249_abnormal_larynx_morphology0.70861491
118MP0001529_abnormal_vocalization0.69914962
119MP0001853_heart_inflammation0.69265352
120MP0000477_abnormal_intestine_morphology0.68029909
121MP0000049_abnormal_middle_ear0.67753468
122MP0005058_abnormal_lysosome_morphology0.67744539
123MP0000759_abnormal_skeletal_muscle0.66976770
124MP0001929_abnormal_gametogenesis0.66954207
125MP0002751_abnormal_autonomic_nervous0.66790477
126MP0002822_catalepsy0.66597184
127MP0005409_darkened_coat_color0.66387872
128MP0005384_cellular_phenotype0.66361720
129MP0001119_abnormal_female_reproductive0.65443956
130MP0003567_abnormal_fetal_cardiomyocyte0.65229167
131MP0004197_abnormal_fetal_growth/weight/0.64770627
132MP0002111_abnormal_tail_morphology0.63845502
133MP0002160_abnormal_reproductive_system0.63458497
134MP0000750_abnormal_muscle_regeneration0.62855380
135MP0005666_abnormal_adipose_tissue0.61904496
136MP0000653_abnormal_sex_gland0.60279364
137MP0008995_early_reproductive_senescence0.59586518
138MP0005621_abnormal_cell_physiology0.59558424
139MP0005266_abnormal_metabolism0.59288639
140MP0003828_pulmonary_edema0.59181751
141MP0000747_muscle_weakness0.58748520
142MP0001186_pigmentation_phenotype0.58523783
143MP0001216_abnormal_epidermal_layer0.58414698
144MP0001727_abnormal_embryo_implantation0.57890129
145MP0000733_abnormal_muscle_development0.56806909

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.41451621
2Abnormal number of erythroid precursors (HP:0012131)4.76618070
3Abnormality of cells of the erythroid lineage (HP:0012130)4.63220945
4Ragged-red muscle fibers (HP:0003200)3.80571641
5Chromosomal breakage induced by crosslinking agents (HP:0003221)3.64227511
6Birth length less than 3rd percentile (HP:0003561)3.62708060
7Cerebral hypomyelination (HP:0006808)3.45311751
8Chromsome breakage (HP:0040012)3.43949399
911 pairs of ribs (HP:0000878)3.39188759
10IgM deficiency (HP:0002850)3.33918350
11Aplastic anemia (HP:0001915)3.26201354
12Medulloblastoma (HP:0002885)3.15991346
13Oral leukoplakia (HP:0002745)3.12539357
14Abnormal protein glycosylation (HP:0012346)3.10502731
15Abnormal glycosylation (HP:0012345)3.10502731
16Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.10502731
17Abnormal protein N-linked glycosylation (HP:0012347)3.10502731
18Macrocytic anemia (HP:0001972)3.05713676
19Rough bone trabeculation (HP:0100670)3.04459100
20Abnormal mitochondria in muscle tissue (HP:0008316)2.95344508
21Abnormality of glycolysis (HP:0004366)2.92745109
22Absent thumb (HP:0009777)2.84420346
23Abnormality of chromosome stability (HP:0003220)2.82952500
24Impulsivity (HP:0100710)2.81506331
25Pallor (HP:0000980)2.80573086
26Abnormality of the preputium (HP:0100587)2.79468411
27Truncus arteriosus (HP:0001660)2.70829519
28Progressive external ophthalmoplegia (HP:0000590)2.69289288
29Acute encephalopathy (HP:0006846)2.67909585
30Increased serum pyruvate (HP:0003542)2.67828780
31Cholecystitis (HP:0001082)2.67631184
32Abnormal gallbladder physiology (HP:0012438)2.67631184
33Lactic acidosis (HP:0003128)2.67615330
34Duplicated collecting system (HP:0000081)2.63727914
35Thrombocytosis (HP:0001894)2.62489814
36Reduced antithrombin III activity (HP:0001976)2.61951089
37Acute necrotizing encephalopathy (HP:0006965)2.60900323
38Multiple enchondromatosis (HP:0005701)2.59019680
39Bone marrow hypocellularity (HP:0005528)2.57124919
40Carpal bone hypoplasia (HP:0001498)2.55582626
41Amaurosis fugax (HP:0100576)2.55368314
42Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.55263813
43Decreased activity of mitochondrial respiratory chain (HP:0008972)2.55263813
44Exercise intolerance (HP:0003546)2.54448149
45Premature graying of hair (HP:0002216)2.53736359
46Cleft eyelid (HP:0000625)2.53212254
47Increased CSF lactate (HP:0002490)2.50667795
48Hepatocellular necrosis (HP:0001404)2.50651291
49Increased intramyocellular lipid droplets (HP:0012240)2.50455402
50Aplasia/Hypoplasia of the sacrum (HP:0008517)2.49101830
51Lymphoma (HP:0002665)2.46898721
52Patellar aplasia (HP:0006443)2.45802112
53Premature ovarian failure (HP:0008209)2.44768730
54Seborrheic dermatitis (HP:0001051)2.44605024
55Redundant skin (HP:0001582)2.43750331
56Spastic diplegia (HP:0001264)2.39788890
57Myelodysplasia (HP:0002863)2.38337177
58Cerebral edema (HP:0002181)2.38123706
59Meckel diverticulum (HP:0002245)2.36947604
60Colon cancer (HP:0003003)2.36502304
61Abnormal trabecular bone morphology (HP:0100671)2.36367411
62Degeneration of anterior horn cells (HP:0002398)2.36009202
63Abnormality of the anterior horn cell (HP:0006802)2.36009202
64Ureteral duplication (HP:0000073)2.34843251
65Testicular atrophy (HP:0000029)2.33154460
66Breast hypoplasia (HP:0003187)2.32756335
67Hypokinesia (HP:0002375)2.32409440
68Congenital malformation of the right heart (HP:0011723)2.31971848
69Double outlet right ventricle (HP:0001719)2.31971848
70Triphalangeal thumb (HP:0001199)2.30666214
71Cutaneous melanoma (HP:0012056)2.30636373
72Aplasia/Hypoplasia of the uvula (HP:0010293)2.30310153
73Abnormality of the renal collecting system (HP:0004742)2.30287477
74Aplasia/Hypoplasia of the patella (HP:0006498)2.29978963
75Mitochondrial inheritance (HP:0001427)2.29274991
76Absent radius (HP:0003974)2.29096273
77Abnormality of the ileum (HP:0001549)2.28292418
78Agnosia (HP:0010524)2.27695830
79Hypertensive crisis (HP:0100735)2.26039098
80Increased muscle lipid content (HP:0009058)2.22434996
81Elevated erythrocyte sedimentation rate (HP:0003565)2.21427180
82Abnormality of the fetal cardiovascular system (HP:0010948)2.21366597
83Abnormal umbilical cord blood vessels (HP:0011403)2.21366597
84Single umbilical artery (HP:0001195)2.21366597
85Acute lymphatic leukemia (HP:0006721)2.21205280
86Chronic otitis media (HP:0000389)2.18649269
87Pancytopenia (HP:0001876)2.18457633
88Sloping forehead (HP:0000340)2.16793766
89Hepatic necrosis (HP:0002605)2.14037264
90Duodenal stenosis (HP:0100867)2.12734426
91Small intestinal stenosis (HP:0012848)2.12734426
92Secondary amenorrhea (HP:0000869)2.11962343
93Abnormal number of incisors (HP:0011064)2.11955160
94Squamous cell carcinoma (HP:0002860)2.11632856
95Thyroiditis (HP:0100646)2.10569784
96Aplasia involving forearm bones (HP:0009822)2.10382664
97Absent forearm bone (HP:0003953)2.10382664
98Abnormality of DNA repair (HP:0003254)2.10095718
99Basal cell carcinoma (HP:0002671)2.09220490
100Spinal muscular atrophy (HP:0007269)2.08472504
101IgG deficiency (HP:0004315)2.06727793
102Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.06541468
103Duplication of thumb phalanx (HP:0009942)2.05342769
104Asplenia (HP:0001746)2.04546312
105Cellulitis (HP:0100658)2.01764257
106Hypergonadotropic hypogonadism (HP:0000815)2.00750421
107Muscle fiber atrophy (HP:0100295)2.00134061
108Microretrognathia (HP:0000308)1.97771518
109Aplasia/Hypoplasia of the thymus (HP:0010515)1.97040667
110B lymphocytopenia (HP:0010976)1.95811613
111Abnormality of B cell number (HP:0010975)1.95811613
112T lymphocytopenia (HP:0005403)1.93550256
113Abnormal lung lobation (HP:0002101)1.92856640
114Petechiae (HP:0000967)1.92707572
115Aplasia/Hypoplasia of the earlobes (HP:0009906)1.91446546
116Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.91382845
117Ependymoma (HP:0002888)1.91036780
118Flared metaphyses (HP:0003015)1.90984206
119Atresia of the external auditory canal (HP:0000413)1.90818136
120Abnormalities of placenta or umbilical cord (HP:0001194)1.90538637
121Death in infancy (HP:0001522)1.90447601
122Partial duplication of thumb phalanx (HP:0009944)1.90201078
123Type 2 muscle fiber atrophy (HP:0003554)1.88655691
124Horseshoe kidney (HP:0000085)1.88632927
125Abnormality of cells of the lymphoid lineage (HP:0012140)1.87277632
126Myopathic facies (HP:0002058)1.87009904
127Progressive muscle weakness (HP:0003323)1.86944804
128Proximal placement of thumb (HP:0009623)1.86715701
129Selective tooth agenesis (HP:0001592)1.85973111
130Unilateral renal agenesis (HP:0000122)1.85590411
131Deviation of the thumb (HP:0009603)1.85582768
132Abnormality of reticulocytes (HP:0004312)1.85340306
133Gout (HP:0001997)1.85201835
134Spastic paraparesis (HP:0002313)1.84879835
135Increased serum lactate (HP:0002151)1.84660975
136Sensory axonal neuropathy (HP:0003390)1.83635509
137Panhypogammaglobulinemia (HP:0003139)1.83435771
138Increased hepatocellular lipid droplets (HP:0006565)1.83144710
139Abnormality of the prostate (HP:0008775)1.83017500
140Trismus (HP:0000211)1.82594596
141Neoplasm of the pancreas (HP:0002894)1.82325409
142Hyperthyroidism (HP:0000836)1.81671616
143Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.81641656
144Glossoptosis (HP:0000162)1.80572563
145Microvesicular hepatic steatosis (HP:0001414)1.80363582
146Progressive macrocephaly (HP:0004481)1.80338932
147Pustule (HP:0200039)1.80054389
148Aplasia/Hypoplasia of the spleen (HP:0010451)1.79686334
149Opisthotonus (HP:0002179)1.77012179
150Hypoplastic left heart (HP:0004383)1.76977210
151Type I transferrin isoform profile (HP:0003642)1.76513181
152Cholelithiasis (HP:0001081)1.76444578
153Abnormality of the umbilical cord (HP:0010881)1.76325940
154Unsteady gait (HP:0002317)1.76114358
155Abnormality of T cell number (HP:0011839)1.76018381
156CNS hypomyelination (HP:0003429)1.75854904
1573-Methylglutaconic aciduria (HP:0003535)1.75564719
158Respiratory difficulties (HP:0002880)1.75235559
159Sparse eyelashes (HP:0000653)1.73932106
160Shoulder girdle muscle weakness (HP:0003547)1.73611744
161Abnormality of the tricuspid valve (HP:0001702)1.73236096
162Septate vagina (HP:0001153)1.72575613
163Postnatal microcephaly (HP:0005484)1.69616444
164Premature skin wrinkling (HP:0100678)1.69315884
165Abnormality of methionine metabolism (HP:0010901)1.69209226
166Impaired proprioception (HP:0010831)1.68148702
167Lipid accumulation in hepatocytes (HP:0006561)1.65819764

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.93940617
2VRK24.82459284
3SMG14.53738922
4WEE13.36361050
5EIF2AK13.19506194
6TSSK62.58585553
7PBK2.51463167
8TAF12.47733954
9PRPF4B2.46553810
10IRAK32.39510884
11CDC72.39228537
12MAP4K12.17231927
13NEK22.16001195
14STK162.06079140
15SCYL21.92438455
16NME21.91313802
17BTK1.84947684
18NEK11.81174653
19VRK11.72653158
20MKNK11.70290560
21ICK1.70150542
22BCKDK1.69638967
23PIM21.63324813
24TLK11.63114396
25EIF2AK31.60884771
26PLK11.59928797
27PASK1.59845213
28MKNK21.59216419
29YES11.56599713
30SRPK11.56555684
31EEF2K1.55755157
32BLK1.55279279
33CDK191.52500587
34DYRK31.52275755
35BRSK21.52098916
36CDK71.50713089
37RPS6KB21.47501594
38CDK41.43499053
39TXK1.42722423
40TRIB31.42489041
41CCNB11.39428026
42ATR1.39401088
43ACVR1B1.37500363
44TTK1.33094215
45AURKB1.27824519
46PLK31.25439405
47FRK1.23706354
48TEC1.23331080
49CLK11.22708847
50NUAK11.19738961
51DAPK11.17567935
52TESK21.15166893
53CDK81.13063411
54FLT31.12468287
55MAP3K141.10985627
56FGFR31.09134364
57ZAP701.09100599
58PDK21.02586084
59BRSK11.01619600
60MAP3K110.96306782
61CHEK20.94100236
62NME10.92057347
63MAPK110.91607298
64ITK0.91602013
65RPS6KA40.89261363
66IRAK20.87504859
67TESK10.87285972
68CHEK10.86888317
69IRAK40.86400420
70MAP3K100.86002057
71ALK0.82714600
72PIM10.82666938
73IKBKB0.82310726
74EPHA20.82092691
75PLK40.81432203
76BRAF0.78757772
77CDK90.76993914
78CSF1R0.75219980
79AKT20.71789122
80LYN0.69971749
81CDK120.68004072
82GRK60.66690207
83AURKA0.66618884
84LCK0.66528213
85CSNK2A20.65935047
86CSNK2A10.65076179
87CSNK1G30.63831324
88TAOK20.63748237
89ARAF0.62786894
90CSNK1A1L0.62379396
91CDK20.61696373
92MAPKAPK30.58924479
93PAK40.58515198
94MAP3K80.58246695
95PRKCI0.58154808
96MAPKAPK50.55807220
97SYK0.55719248
98STK40.54788339
99TGFBR10.53563811
100STK100.53390614
101MST40.53380723
102EIF2AK20.53333413
103HCK0.53059512
104CSNK1G10.52350744
105ATM0.52345519
106PAK10.52017479
107MAPKAPK20.50416426
108KIT0.48420381
109DAPK30.48131880
110MAP3K60.46605852
111ADRBK20.45898220
112KDR0.44466142
113ABL20.43106616
114IKBKE0.42986586
115CDK60.42984867
116MELK0.42314799
117PRKD30.42061536
118TBK10.41647226
119ZAK0.40677733
120MTOR0.39228342
121CDK10.38909519
122ILK0.38686723
123JAK30.37965318
124NLK0.37939421
125TTN0.37857039
126MAP2K30.36367594
127FGFR40.36066167
128DYRK20.35563224
129RAF10.35260196
130CDK11A0.34835829
131RPS6KA50.34364897
132LRRK20.33934706
133CSNK1G20.31954666
134BMX0.31767307
135SIK10.28605231
136MST1R0.27685048
137ERBB40.25923973
138TRIM280.24452030
139ERN10.23353576

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.41938358
2Mismatch repair_Homo sapiens_hsa034304.20924763
3Ribosome_Homo sapiens_hsa030103.69037150
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.37733422
5Base excision repair_Homo sapiens_hsa034103.23035165
6RNA polymerase_Homo sapiens_hsa030203.21705535
7Spliceosome_Homo sapiens_hsa030403.12429917
8Proteasome_Homo sapiens_hsa030502.95405637
9Nucleotide excision repair_Homo sapiens_hsa034202.88660887
10Homologous recombination_Homo sapiens_hsa034402.79142972
11RNA transport_Homo sapiens_hsa030132.67038022
12Cell cycle_Homo sapiens_hsa041102.47447931
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.37338787
14Pyrimidine metabolism_Homo sapiens_hsa002402.34963586
15Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.29205989
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.28628325
17One carbon pool by folate_Homo sapiens_hsa006702.26564223
18Non-homologous end-joining_Homo sapiens_hsa034502.05650155
19Fanconi anemia pathway_Homo sapiens_hsa034601.75043452
20Basal transcription factors_Homo sapiens_hsa030221.74686141
21RNA degradation_Homo sapiens_hsa030181.74234598
22Carbon metabolism_Homo sapiens_hsa012001.62318145
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.59192397
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.56855556
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.38415506
26p53 signaling pathway_Homo sapiens_hsa041151.36578555
27Primary immunodeficiency_Homo sapiens_hsa053401.36302370
28Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.33116378
29mRNA surveillance pathway_Homo sapiens_hsa030151.32959526
30Purine metabolism_Homo sapiens_hsa002301.29126152
31Fatty acid elongation_Homo sapiens_hsa000621.28481544
32Vitamin B6 metabolism_Homo sapiens_hsa007501.27745009
33Epstein-Barr virus infection_Homo sapiens_hsa051691.26699071
34Pyruvate metabolism_Homo sapiens_hsa006201.23763495
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.19759969
36Antigen processing and presentation_Homo sapiens_hsa046121.04199015
37Galactose metabolism_Homo sapiens_hsa000521.01002891
38Legionellosis_Homo sapiens_hsa051341.00016783
39Herpes simplex infection_Homo sapiens_hsa051680.99915119
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.99872760
41Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.98322637
42Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.97661403
43Pentose phosphate pathway_Homo sapiens_hsa000300.91491914
44Measles_Homo sapiens_hsa051620.88735052
45Allograft rejection_Homo sapiens_hsa053300.86907107
46NF-kappa B signaling pathway_Homo sapiens_hsa040640.83530864
47Sulfur relay system_Homo sapiens_hsa041220.82167233
48Steroid biosynthesis_Homo sapiens_hsa001000.81606671
49Viral carcinogenesis_Homo sapiens_hsa052030.81014378
50Systemic lupus erythematosus_Homo sapiens_hsa053220.79651821
51Arginine and proline metabolism_Homo sapiens_hsa003300.78873894
52Protein export_Homo sapiens_hsa030600.78235936
53Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.77864796
54Folate biosynthesis_Homo sapiens_hsa007900.73574400
55Bladder cancer_Homo sapiens_hsa052190.72692461
56HTLV-I infection_Homo sapiens_hsa051660.71903399
57Oocyte meiosis_Homo sapiens_hsa041140.71154930
58Shigellosis_Homo sapiens_hsa051310.70707438
59Sulfur metabolism_Homo sapiens_hsa009200.66909348
60Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.65759007
61B cell receptor signaling pathway_Homo sapiens_hsa046620.65239697
62Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.64932758
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63535461
64Cysteine and methionine metabolism_Homo sapiens_hsa002700.62954834
65Biosynthesis of amino acids_Homo sapiens_hsa012300.61873537
66Metabolic pathways_Homo sapiens_hsa011000.61281927
67Alzheimers disease_Homo sapiens_hsa050100.61036593
68Intestinal immune network for IgA production_Homo sapiens_hsa046720.59312990
69Apoptosis_Homo sapiens_hsa042100.57494589
70Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57423512
71Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.55181207
72Hepatitis B_Homo sapiens_hsa051610.55145893
73T cell receptor signaling pathway_Homo sapiens_hsa046600.55129462
74RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.53960853
75Cyanoamino acid metabolism_Homo sapiens_hsa004600.53446483
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.53264753
77Leishmaniasis_Homo sapiens_hsa051400.52797398
78Small cell lung cancer_Homo sapiens_hsa052220.51483930
79Hematopoietic cell lineage_Homo sapiens_hsa046400.51289165
80Other glycan degradation_Homo sapiens_hsa005110.50035185
81Type I diabetes mellitus_Homo sapiens_hsa049400.49723805
82Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.49336925
83Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47371242
84Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47145123
85Parkinsons disease_Homo sapiens_hsa050120.46274882
86Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.44977459
87Thyroid cancer_Homo sapiens_hsa052160.44555564
88Graft-versus-host disease_Homo sapiens_hsa053320.44349263
89Chronic myeloid leukemia_Homo sapiens_hsa052200.44244453
90Selenocompound metabolism_Homo sapiens_hsa004500.44015681
91Acute myeloid leukemia_Homo sapiens_hsa052210.43645269
92Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.43112886
93NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43018095
94Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42882035
95Notch signaling pathway_Homo sapiens_hsa043300.40479275
96Viral myocarditis_Homo sapiens_hsa054160.40306327
97Pertussis_Homo sapiens_hsa051330.40216240
98Arginine biosynthesis_Homo sapiens_hsa002200.39916559
99Colorectal cancer_Homo sapiens_hsa052100.39432778
100Influenza A_Homo sapiens_hsa051640.39365838
101Huntingtons disease_Homo sapiens_hsa050160.38053624
102Fatty acid metabolism_Homo sapiens_hsa012120.36653434
103Propanoate metabolism_Homo sapiens_hsa006400.35186476
104Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.34608351
105MicroRNAs in cancer_Homo sapiens_hsa052060.33888406
106Lysine degradation_Homo sapiens_hsa003100.33677639
107Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32644773
108Vibrio cholerae infection_Homo sapiens_hsa051100.31206303
109Non-small cell lung cancer_Homo sapiens_hsa052230.30648975
110Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.30562528
111Pancreatic cancer_Homo sapiens_hsa052120.30484347
112Autoimmune thyroid disease_Homo sapiens_hsa053200.30414685
113N-Glycan biosynthesis_Homo sapiens_hsa005100.29868348
114Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.26410741
115Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.26324453
116Regulation of autophagy_Homo sapiens_hsa041400.25626730
117Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.25365369
118Phenylalanine metabolism_Homo sapiens_hsa003600.25132051
119Toll-like receptor signaling pathway_Homo sapiens_hsa046200.24923687
120Glutathione metabolism_Homo sapiens_hsa004800.24230062
121Jak-STAT signaling pathway_Homo sapiens_hsa046300.23896429
122Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.20902970
123Toxoplasmosis_Homo sapiens_hsa051450.19655682
124Oxidative phosphorylation_Homo sapiens_hsa001900.18327575
125Pentose and glucuronate interconversions_Homo sapiens_hsa000400.18281991
126Peroxisome_Homo sapiens_hsa041460.18138573
127Malaria_Homo sapiens_hsa051440.16991270
128Alcoholism_Homo sapiens_hsa050340.16176168
129Vitamin digestion and absorption_Homo sapiens_hsa049770.15699057
130Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.15552213
131Fructose and mannose metabolism_Homo sapiens_hsa000510.15077318
132Central carbon metabolism in cancer_Homo sapiens_hsa052300.14845288
133Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.14582239
134Longevity regulating pathway - mammal_Homo sapiens_hsa042110.14079568
135HIF-1 signaling pathway_Homo sapiens_hsa040660.12678007
136Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.12197638

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