DPH3P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cullin deneddylation (GO:0010388)6.08902992
2protein deneddylation (GO:0000338)5.49704261
3prenylation (GO:0097354)5.19185465
4protein prenylation (GO:0018342)5.19185465
5respiratory chain complex IV assembly (GO:0008535)5.12334429
6synapsis (GO:0007129)5.12101908
7centriole replication (GO:0007099)4.91618805
8proteasome assembly (GO:0043248)4.83963623
9establishment of protein localization to mitochondrial membrane (GO:0090151)4.79713989
10chaperone-mediated protein transport (GO:0072321)4.76212100
11negative regulation of mast cell activation (GO:0033004)4.58303255
12negative regulation of heart rate (GO:0010459)4.42617665
13DNA replication-dependent nucleosome organization (GO:0034723)4.33748432
14DNA replication-dependent nucleosome assembly (GO:0006335)4.33748432
15positive regulation of fibroblast migration (GO:0010763)4.30426738
16cytochrome complex assembly (GO:0017004)4.28774160
17water-soluble vitamin biosynthetic process (GO:0042364)4.14628006
18CENP-A containing nucleosome assembly (GO:0034080)4.10814821
19chromatin remodeling at centromere (GO:0031055)3.97287623
20deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.77044137
21rRNA modification (GO:0000154)3.72555554
22regulation of urine volume (GO:0035809)3.65069218
23mature B cell differentiation involved in immune response (GO:0002313)3.53893133
24ATP synthesis coupled proton transport (GO:0015986)3.51730313
25energy coupled proton transport, down electrochemical gradient (GO:0015985)3.51730313
26mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.50018115
27regulation of circadian sleep/wake cycle (GO:0042749)3.47222073
28regulation of circadian sleep/wake cycle, sleep (GO:0045187)3.47222073
29negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 3.46117513
30phagocytosis, engulfment (GO:0006911)3.44222716
31negative regulation of membrane potential (GO:0045837)3.41979880
32negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.41851488
33transcription elongation from RNA polymerase III promoter (GO:0006385)3.40096436
34termination of RNA polymerase III transcription (GO:0006386)3.40096436
35DNA replication-independent nucleosome organization (GO:0034724)3.32923555
36DNA replication-independent nucleosome assembly (GO:0006336)3.32923555
37transepithelial transport (GO:0070633)3.32221539
38inositol phosphate dephosphorylation (GO:0046855)3.31401264
39phosphorylated carbohydrate dephosphorylation (GO:0046838)3.31401264
40negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.28469119
41rRNA methylation (GO:0031167)3.27242011
42regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.20703050
43protein neddylation (GO:0045116)3.20575356
44deoxyribose phosphate biosynthetic process (GO:0046385)3.20445855
452-deoxyribonucleotide biosynthetic process (GO:0009265)3.20445855
46histone exchange (GO:0043486)3.19587521
47mature B cell differentiation (GO:0002335)3.18301651
48DNA double-strand break processing (GO:0000729)3.17046766
49mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.16740795
50platelet dense granule organization (GO:0060155)3.16059166
51regulation of glucokinase activity (GO:0033131)3.13542508
52regulation of hexokinase activity (GO:1903299)3.13542508
53regulation of female gonad development (GO:2000194)3.12748373
54centriole assembly (GO:0098534)3.10287910
55regulation of DNA endoreduplication (GO:0032875)3.08950734
56regulation of meiosis I (GO:0060631)3.04169016
57regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.02511681
58vitamin biosynthetic process (GO:0009110)3.00972128
59positive regulation of T cell cytokine production (GO:0002726)3.00699417
60protein K6-linked ubiquitination (GO:0085020)3.00394758
61positive regulation of G1/S transition of mitotic cell cycle (GO:1900087)2.99261019
62positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.97063045
63tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.96714110
64RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.96714110
65positive regulation of cell cycle G1/S phase transition (GO:1902808)2.95618453
66regulation of cellular amino acid metabolic process (GO:0006521)2.95207169
67inositol phosphate catabolic process (GO:0071545)2.89983291
68regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.88772059
69regulation of glomerular filtration (GO:0003093)2.87788263
70mitochondrial respiratory chain complex assembly (GO:0033108)2.85886600
71intra-S DNA damage checkpoint (GO:0031573)2.84108745
72circadian sleep/wake cycle process (GO:0022410)2.83684071
73neutrophil activation involved in immune response (GO:0002283)2.83198427
74pseudouridine synthesis (GO:0001522)2.82979046
75anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.81859099
76response to testosterone (GO:0033574)2.79154519
77intracellular protein transmembrane import (GO:0044743)2.78623280
78negative regulation of ligase activity (GO:0051352)2.77658113
79negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.77658113
80negative regulation of neurotransmitter secretion (GO:0046929)2.75058293
81regulation of mitochondrial translation (GO:0070129)2.73349242
82DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.73331207
83protein complex biogenesis (GO:0070271)2.72679310
84DNA catabolic process, exonucleolytic (GO:0000738)2.72446453
85regulation of RIG-I signaling pathway (GO:0039535)2.72082950
86histone H2A acetylation (GO:0043968)2.71706107
87aldehyde catabolic process (GO:0046185)2.71390094
88nucleosome assembly (GO:0006334)2.71260312
89signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.71173409
90signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.71173409
91signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.71173409
92S-adenosylmethionine metabolic process (GO:0046500)2.70552755
93deoxyribonucleotide biosynthetic process (GO:0009263)2.69655397
94signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.68684415
95intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.68684415
96C4-dicarboxylate transport (GO:0015740)2.66600620
97response to gravity (GO:0009629)2.66121089
98protein-DNA complex assembly (GO:0065004)2.65827113
99regulation of triglyceride catabolic process (GO:0010896)2.65402057
100regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.65401125

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.41127310
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.59512156
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.28724698
4EZH2_22144423_ChIP-Seq_EOC_Human4.24871245
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.76561169
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.70974981
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.15284018
8ELK1_19687146_ChIP-ChIP_HELA_Human2.80303720
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.75021417
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.64314030
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.57655774
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.41713284
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.38450320
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.37979105
15VDR_23849224_ChIP-Seq_CD4+_Human2.19257533
16POU5F1_16153702_ChIP-ChIP_HESCs_Human2.18832514
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.18649979
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.11193596
19FOXP3_21729870_ChIP-Seq_TREG_Human2.03640059
20VDR_22108803_ChIP-Seq_LS180_Human2.01882132
21PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.99623734
22CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.97231076
23CIITA_25753668_ChIP-Seq_RAJI_Human1.87959462
24POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.86466621
25CREB1_15753290_ChIP-ChIP_HEK293T_Human1.81088732
26FUS_26573619_Chip-Seq_HEK293_Human1.80161416
27EWS_26573619_Chip-Seq_HEK293_Human1.77002819
28TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.76652915
29ETS1_20019798_ChIP-Seq_JURKAT_Human1.76295451
30MYC_18940864_ChIP-ChIP_HL60_Human1.75502244
31ZNF274_21170338_ChIP-Seq_K562_Hela1.74132984
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.73931726
33EGR1_23403033_ChIP-Seq_LIVER_Mouse1.71747256
34ELF1_17652178_ChIP-ChIP_JURKAT_Human1.68563830
35SRF_21415370_ChIP-Seq_HL-1_Mouse1.67569026
36E2F7_22180533_ChIP-Seq_HELA_Human1.65748481
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.59046135
38NANOG_16153702_ChIP-ChIP_HESCs_Human1.58986140
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58342588
40FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.56460157
41FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.55686890
42MYC_19030024_ChIP-ChIP_MESCs_Mouse1.53019624
43IRF1_19129219_ChIP-ChIP_H3396_Human1.51647795
44TAF15_26573619_Chip-Seq_HEK293_Human1.50444806
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.49818124
46PADI4_21655091_ChIP-ChIP_MCF-7_Human1.49298740
47P300_19829295_ChIP-Seq_ESCs_Human1.49263313
48HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.45535856
49DCP1A_22483619_ChIP-Seq_HELA_Human1.44444817
50SALL1_21062744_ChIP-ChIP_HESCs_Human1.43814764
51NANOG_19829295_ChIP-Seq_ESCs_Human1.41970724
52SOX2_19829295_ChIP-Seq_ESCs_Human1.41970724
53FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.36948700
54SOX2_16153702_ChIP-ChIP_HESCs_Human1.36564852
55E2F1_21310950_ChIP-Seq_MCF-7_Human1.32794794
56E2F1_18555785_ChIP-Seq_MESCs_Mouse1.30919176
57MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.29629177
58THAP11_20581084_ChIP-Seq_MESCs_Mouse1.29199721
59POU3F2_20337985_ChIP-ChIP_501MEL_Human1.26753013
60IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.25571759
61MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.23916613
62GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16488484
63AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13888982
64FOXA1_27270436_Chip-Seq_PROSTATE_Human1.12685859
65FOXA1_25329375_ChIP-Seq_VCAP_Human1.12685859
66GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11169185
67MYC_18555785_ChIP-Seq_MESCs_Mouse1.10038178
68GBX2_23144817_ChIP-Seq_PC3_Human1.06958299
69CTBP2_25329375_ChIP-Seq_LNCAP_Human1.05526254
70CBP_20019798_ChIP-Seq_JUKART_Human1.03497397
71IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.03497397
72ERG_20517297_ChIP-Seq_VCAP_Human1.00993129
73EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.98627799
74UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97991092
75AUTS2_25519132_ChIP-Seq_293T-REX_Human0.96938090
76MYC_18358816_ChIP-ChIP_MESCs_Mouse0.96446529
77SALL4_22934838_ChIP-ChIP_CD34+_Human0.96136829
78PHF8_20622853_ChIP-Seq_HELA_Human0.95923552
79SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95308016
80AR_21572438_ChIP-Seq_LNCaP_Human0.92639760
81RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.92252979
82ELF5_23300383_ChIP-Seq_T47D_Human0.90716561
83POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.88110555
84NOTCH1_21737748_ChIP-Seq_TLL_Human0.86797729
85YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.86389547
86CTBP1_25329375_ChIP-Seq_LNCAP_Human0.86188485
87NRF2_20460467_ChIP-Seq_MEFs_Mouse0.86026719
88NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.86026719
89NCOR_22424771_ChIP-Seq_293T_Human0.82187739
90RBPJ_21746931_ChIP-Seq_IB4_Human0.81602409
91FOXA1_21572438_ChIP-Seq_LNCaP_Human0.80633740
92EZH2_27294783_Chip-Seq_NPCs_Mouse0.79988957
93EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.78943469
94YY1_21170310_ChIP-Seq_MESCs_Mouse0.78586474
95GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.78484654
96CBP_21632823_ChIP-Seq_H3396_Human0.77108219
97HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.76925717
98AR_25329375_ChIP-Seq_VCAP_Human0.76444647
99CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.76363833
100CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.76126369

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.03795205
2MP0002736_abnormal_nociception_after3.34991161
3MP0003806_abnormal_nucleotide_metabolis3.14820163
4MP0002876_abnormal_thyroid_physiology3.09404645
5MP0006072_abnormal_retinal_apoptosis3.05399184
6MP0003718_maternal_effect2.94461920
7MP0005367_renal/urinary_system_phenotyp2.92604993
8MP0000516_abnormal_urinary_system2.92604993
9MP0003880_abnormal_central_pattern2.64014430
10MP0001188_hyperpigmentation2.57087618
11MP0002837_dystrophic_cardiac_calcinosis2.56413725
12MP0003011_delayed_dark_adaptation2.51191450
13MP0002396_abnormal_hematopoietic_system2.42187984
14MP0003724_increased_susceptibility_to2.34755928
15MP0001968_abnormal_touch/_nociception2.33762998
16MP0002234_abnormal_pharynx_morphology2.12225638
17MP0003890_abnormal_embryonic-extraembry2.00372798
18MP0003646_muscle_fatigue1.98744183
19MP0003123_paternal_imprinting1.91713630
20MP0008875_abnormal_xenobiotic_pharmacok1.89344578
21MP0001835_abnormal_antigen_presentation1.87903481
22MP0005075_abnormal_melanosome_morpholog1.77053163
23MP0003195_calcinosis1.75063347
24MP0009046_muscle_twitch1.72617163
25MP0005645_abnormal_hypothalamus_physiol1.70686309
26MP0003121_genomic_imprinting1.57161062
27MP0005671_abnormal_response_to1.52769838
28MP0003786_premature_aging1.52494228
29MP0001905_abnormal_dopamine_level1.49430521
30MP0005253_abnormal_eye_physiology1.49066239
31MP0005174_abnormal_tail_pigmentation1.47344828
32MP0002138_abnormal_hepatobiliary_system1.45553782
33MP0005408_hypopigmentation1.43174572
34MP0010094_abnormal_chromosome_stability1.41145784
35MP0005389_reproductive_system_phenotype1.39356139
36MP0004957_abnormal_blastocyst_morpholog1.37318434
37MP0010368_abnormal_lymphatic_system1.35906310
38MP0005646_abnormal_pituitary_gland1.34855362
39MP0001545_abnormal_hematopoietic_system1.34350520
40MP0005397_hematopoietic_system_phenotyp1.34350520
41MP0002735_abnormal_chemical_nociception1.25389538
42MP0000372_irregular_coat_pigmentation1.25362242
43MP0008004_abnormal_stomach_pH1.23362215
44MP0003136_yellow_coat_color1.23301344
45MP0008932_abnormal_embryonic_tissue1.23180645
46MP0003122_maternal_imprinting1.22169944
47MP0001919_abnormal_reproductive_system1.21123445
48MP0000613_abnormal_salivary_gland1.17207616
49MP0003787_abnormal_imprinting1.16319053
50MP0000538_abnormal_urinary_bladder1.14073916
51MP0000049_abnormal_middle_ear1.14057424
52MP0004142_abnormal_muscle_tone1.12749711
53MP0002148_abnormal_hypersensitivity_rea1.11150034
54MP0008775_abnormal_heart_ventricle1.10552361
55MP0003119_abnormal_digestive_system1.06770916
56MP0002938_white_spotting1.05619262
57MP0004215_abnormal_myocardial_fiber1.00759977
58MP0001879_abnormal_lymphatic_vessel0.98064364
59MP0003448_altered_tumor_morphology0.97731960
60MP0002160_abnormal_reproductive_system0.97614172
61MP0003755_abnormal_palate_morphology0.95793406
62MP0000749_muscle_degeneration0.92966163
63MP0001177_atelectasis0.92532641
64MP0005332_abnormal_amino_acid0.92098752
65MP0008789_abnormal_olfactory_epithelium0.91417297
66MP0001119_abnormal_female_reproductive0.89549832
67MP0006036_abnormal_mitochondrial_physio0.89191039
68MP0002277_abnormal_respiratory_mucosa0.89137159
69MP0002166_altered_tumor_susceptibility0.88876858
70MP0010155_abnormal_intestine_physiology0.88780846
71MP0003937_abnormal_limbs/digits/tail_de0.87747266
72MP0002102_abnormal_ear_morphology0.86987783
73MP0009785_altered_susceptibility_to0.86721523
74MP0004084_abnormal_cardiac_muscle0.85797235
75MP0002163_abnormal_gland_morphology0.85406586
76MP0002090_abnormal_vision0.85232034
77MP0001756_abnormal_urination0.84993021
78MP0001293_anophthalmia0.83218944
79MP0002095_abnormal_skin_pigmentation0.82167099
80MP0000465_gastrointestinal_hemorrhage0.81625702
81MP0002210_abnormal_sex_determination0.79155444
82MP0001970_abnormal_pain_threshold0.78534074
83MP0005410_abnormal_fertilization0.76775295
84MP0008058_abnormal_DNA_repair0.76100225
85MP0009250_abnormal_appendicular_skeleto0.76037688
86MP0000653_abnormal_sex_gland0.74583117
87MP0000631_abnormal_neuroendocrine_gland0.74161512
88MP0005551_abnormal_eye_electrophysiolog0.74099364
89MP0009745_abnormal_behavioral_response0.71484641
90MP0002019_abnormal_tumor_incidence0.71371255
91MP0001346_abnormal_lacrimal_gland0.69872824
92MP0001501_abnormal_sleep_pattern0.69092997
93MP0001191_abnormal_skin_condition0.67941896
94MP0001764_abnormal_homeostasis0.66746415
95MP0009764_decreased_sensitivity_to0.66054184
96MP0005195_abnormal_posterior_eye0.65244446
97MP0005395_other_phenotype0.65221594
98MP0002928_abnormal_bile_duct0.65009725
99MP0002006_tumorigenesis0.63870121
100MP0001145_abnormal_male_reproductive0.62928709

Predicted human phenotypes

RankGene SetZ-score
1Metaphyseal dysplasia (HP:0100255)4.77742908
2Hepatocellular necrosis (HP:0001404)4.24462006
3Hepatic necrosis (HP:0002605)3.93450850
4Aplastic anemia (HP:0001915)3.72968106
5Increased CSF lactate (HP:0002490)3.61685397
6Aplasia/Hypoplasia of the uvula (HP:0010293)3.59242353
7Lipid accumulation in hepatocytes (HP:0006561)3.53739876
8Mitochondrial inheritance (HP:0001427)3.51566999
9Abnormality of the preputium (HP:0100587)3.41618694
10Limb hypertonia (HP:0002509)3.41014456
11Chromsome breakage (HP:0040012)3.40699397
12Increased hepatocellular lipid droplets (HP:0006565)3.34284111
13Chromosomal breakage induced by crosslinking agents (HP:0003221)3.29617092
14Meckel diverticulum (HP:0002245)3.19544830
15Hyperglycinemia (HP:0002154)3.11316065
16Clubbing of toes (HP:0100760)3.10969450
17Absent frontal sinuses (HP:0002688)3.08232371
18Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.06070201
19Abnormality of the ileum (HP:0001549)3.02952148
20Hypoglycemic seizures (HP:0002173)2.95012038
21Short tibia (HP:0005736)2.91458139
22Glossoptosis (HP:0000162)2.91402485
23Progressive macrocephaly (HP:0004481)2.85462739
24Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.78949592
25Abnormality of the costochondral junction (HP:0000919)2.77487798
26Aplasia/Hypoplasia of the tibia (HP:0005772)2.68591794
27Abnormality of chromosome stability (HP:0003220)2.66266392
28Neonatal respiratory distress (HP:0002643)2.65669081
29Renal Fanconi syndrome (HP:0001994)2.64102937
30Exercise-induced muscle cramps (HP:0003710)2.61032740
31Alveolar cell carcinoma (HP:0006519)2.60062536
32Abnormality of the phalanges of the 2nd finger (HP:0009541)2.57558134
33Acute encephalopathy (HP:0006846)2.56214554
34Exertional dyspnea (HP:0002875)2.54604710
35Congenital, generalized hypertrichosis (HP:0004540)2.54306606
36Abnormal lung lobation (HP:0002101)2.52198788
37Dyschromatopsia (HP:0007641)2.46677636
38Abnormality of the anterior horn cell (HP:0006802)2.44653239
39Degeneration of anterior horn cells (HP:0002398)2.44653239
40Small intestinal stenosis (HP:0012848)2.41784943
41Duodenal stenosis (HP:0100867)2.41784943
42Abnormal sex determination (HP:0012244)2.40765511
43Sex reversal (HP:0012245)2.40765511
44Acute necrotizing encephalopathy (HP:0006965)2.38879168
45Nephroblastoma (Wilms tumor) (HP:0002667)2.38068947
46Hypokinesia (HP:0002375)2.36395623
47Microglossia (HP:0000171)2.28680136
48Decreased electroretinogram (ERG) amplitude (HP:0000654)2.28491082
49Increased serum lactate (HP:0002151)2.25345377
50Embryonal renal neoplasm (HP:0011794)2.25326775
51Abnormality of the frontal sinuses (HP:0002687)2.20090418
52Short middle phalanx of the 5th finger (HP:0004220)2.17956715
53Neoplasm of the tracheobronchial system (HP:0100552)2.15629854
543-Methylglutaconic aciduria (HP:0003535)2.14103865
55Progressive microcephaly (HP:0000253)2.13309950
56Neoplasm of the adrenal cortex (HP:0100641)2.10074505
57Hemiparesis (HP:0001269)2.10002309
58Respiratory failure (HP:0002878)2.09754202
59Lactic acidosis (HP:0003128)2.09344512
60Global brain atrophy (HP:0002283)2.09310605
61Abnormality of the duodenum (HP:0002246)2.09232502
62Hyperglycinuria (HP:0003108)2.06837677
63Abnormality of the axillary hair (HP:0100134)2.06058231
64Abnormality of secondary sexual hair (HP:0009888)2.06058231
65Subcapsular cataract (HP:0000523)2.06004495
66Hypoglycemic coma (HP:0001325)2.05566635
67Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.04300374
68Myoglobinuria (HP:0002913)2.03227436
69Microretrognathia (HP:0000308)2.03006755
70Stenosis of the external auditory canal (HP:0000402)2.02712421
71Poor suck (HP:0002033)1.99736039
72Hyperinsulinemic hypoglycemia (HP:0000825)1.99036076
73Decreased central vision (HP:0007663)1.97536899
74Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.95707547
75Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.95573660
76Testicular neoplasm (HP:0010788)1.95156084
77CNS demyelination (HP:0007305)1.93912874
78Congenital ichthyosiform erythroderma (HP:0007431)1.92766051
79Abolished electroretinogram (ERG) (HP:0000550)1.90794412
80Aplasia/Hypoplasia of the tongue (HP:0010295)1.90447308
81Cerebral edema (HP:0002181)1.89734930
82Abnormal mitochondria in muscle tissue (HP:0008316)1.89329826
83Abnormal epiphyseal ossification (HP:0010656)1.88072337
84Delayed epiphyseal ossification (HP:0002663)1.86511505
85Pancytopenia (HP:0001876)1.86431039
86Cutaneous melanoma (HP:0012056)1.86075369
87Arteriovenous malformation (HP:0100026)1.85385508
88Abnormality of serine family amino acid metabolism (HP:0010894)1.84109416
89Abnormality of glycine metabolism (HP:0010895)1.84109416
90Supernumerary spleens (HP:0009799)1.82201954
91Dry hair (HP:0011359)1.81971647
92Male pseudohermaphroditism (HP:0000037)1.81598651
93Flat capital femoral epiphysis (HP:0003370)1.81403777
94Stomach cancer (HP:0012126)1.80874505
95Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.79385705
96Bundle branch block (HP:0011710)1.78319034
97Colon cancer (HP:0003003)1.78246868
98Increased intramyocellular lipid droplets (HP:0012240)1.78206064
99Irregular epiphyses (HP:0010582)1.77284107
100Abnormality of methionine metabolism (HP:0010901)1.76244227

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NUAK14.48783224
2TIE14.32421694
3CDK193.80110403
4CDC72.84568471
5OXSR12.79023407
6BCKDK2.76129727
7BMPR22.69843674
8BUB12.66428285
9EIF2AK32.63665699
10MST42.62679543
11MAP3K122.62211069
12ACVR1B2.45916875
13FRK2.44474025
14TLK12.34695322
15STK242.31971852
16ZAK2.29223441
17MKNK22.27448950
18TNIK1.96059408
19PRKD31.89872035
20MAP4K21.88541180
21BMPR1B1.87185964
22STK391.63098742
23TAOK31.62574288
24FLT31.62207583
25PLK41.54720100
26GRK11.40421120
27VRK11.38803434
28WNK31.34730371
29SIK31.34242992
30MKNK11.30997550
31WEE11.28852381
32STK161.27277574
33ERBB31.10956622
34TRPM71.01739198
35VRK21.00739785
36EIF2AK10.97872862
37PLK20.96741434
38TEC0.96440479
39AKT30.93746538
40EIF2AK20.91318970
41RPS6KA50.87611040
42WNK10.85446174
43KIT0.84997861
44NEK10.83922931
45CDK80.83587573
46TGFBR10.83269432
47MAPK130.82863754
48PHKG10.82638089
49PHKG20.82638089
50MYLK0.82378496
51CSNK1G20.80452748
52MARK30.79619028
53TRIM280.79046581
54DYRK20.78756793
55STK38L0.78323562
56CSNK1G10.78080384
57CSNK1G30.76816641
58STK30.76663303
59CSF1R0.73845558
60CSNK1A1L0.73034983
61PLK30.71033060
62PAK40.62854785
63NME20.62764801
64AURKA0.62487364
65PLK10.59010146
66MAPKAPK50.57867939
67ADRBK20.56342161
68CDK70.54244614
69MINK10.51941379
70PTK2B0.50460293
71IKBKB0.50030094
72DAPK30.48551822
73WNK40.45335393
74BRSK20.43901163
75MAPKAPK30.43662558
76DDR20.41083063
77CHUK0.40261697
78AURKB0.38901942
79PAK10.38638151
80ABL20.36320438
81ERBB40.34541580
82PNCK0.33307899
83CSNK2A10.31681587
84CSNK1D0.28790587
85OBSCN0.27964054
86CHEK20.27943841
87PIM20.27077441
88INSRR0.26718522
89ROCK10.26489248
90FGFR20.26097922
91BRAF0.25457234
92LATS10.24823550
93LRRK20.23662789
94GRK50.23225569
95ABL10.22592013
96PRKG10.19569490
97CSNK2A20.17834787
98HCK0.17716370
99CAMK2D0.16574013
100ILK0.16571741

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053105.10332159
2Intestinal immune network for IgA production_Homo sapiens_hsa046724.29386344
3Allograft rejection_Homo sapiens_hsa053303.83910015
4Autoimmune thyroid disease_Homo sapiens_hsa053203.54523450
5Systemic lupus erythematosus_Homo sapiens_hsa053223.34150998
6Type I diabetes mellitus_Homo sapiens_hsa049403.33292509
7Graft-versus-host disease_Homo sapiens_hsa053323.32356919
8Proteasome_Homo sapiens_hsa030502.86163700
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.26234662
10Sulfur metabolism_Homo sapiens_hsa009202.24939989
11Viral myocarditis_Homo sapiens_hsa054162.19821571
12RNA polymerase_Homo sapiens_hsa030202.07895040
13Protein export_Homo sapiens_hsa030602.06679838
14Oxidative phosphorylation_Homo sapiens_hsa001902.03939179
15Antigen processing and presentation_Homo sapiens_hsa046121.83816553
16Staphylococcus aureus infection_Homo sapiens_hsa051501.82724193
17Rheumatoid arthritis_Homo sapiens_hsa053231.81941445
18Leishmaniasis_Homo sapiens_hsa051401.80743204
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.73649872
20Steroid biosynthesis_Homo sapiens_hsa001001.59229665
21Propanoate metabolism_Homo sapiens_hsa006401.57906949
22Parkinsons disease_Homo sapiens_hsa050121.57848369
23Alcoholism_Homo sapiens_hsa050341.56503499
24DNA replication_Homo sapiens_hsa030301.56189074
25One carbon pool by folate_Homo sapiens_hsa006701.46413022
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.42911912
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.38171185
28Homologous recombination_Homo sapiens_hsa034401.33523008
29Nitrogen metabolism_Homo sapiens_hsa009101.30756531
30Fanconi anemia pathway_Homo sapiens_hsa034601.23301970
31Mismatch repair_Homo sapiens_hsa034301.18315443
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.07128683
33Fatty acid elongation_Homo sapiens_hsa000621.05647728
34Huntingtons disease_Homo sapiens_hsa050161.05519865
35Ribosome_Homo sapiens_hsa030101.04445629
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.02515353
37Spliceosome_Homo sapiens_hsa030401.01381667
38Alzheimers disease_Homo sapiens_hsa050100.98176217
39Toxoplasmosis_Homo sapiens_hsa051450.94491449
40Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.93407423
41Fatty acid metabolism_Homo sapiens_hsa012120.92426025
42Selenocompound metabolism_Homo sapiens_hsa004500.88327785
43Pyrimidine metabolism_Homo sapiens_hsa002400.86912177
44RNA degradation_Homo sapiens_hsa030180.84922875
45Herpes simplex infection_Homo sapiens_hsa051680.82537210
46Base excision repair_Homo sapiens_hsa034100.82242719
47Hematopoietic cell lineage_Homo sapiens_hsa046400.81974273
48Phototransduction_Homo sapiens_hsa047440.81551588
49Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.76826167
50Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.75782405
51Non-homologous end-joining_Homo sapiens_hsa034500.71024140
52Basal transcription factors_Homo sapiens_hsa030220.68445191
53Purine metabolism_Homo sapiens_hsa002300.68251048
54Butanoate metabolism_Homo sapiens_hsa006500.66312434
55RNA transport_Homo sapiens_hsa030130.65912051
56Epstein-Barr virus infection_Homo sapiens_hsa051690.65332716
57Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.59562382
58Tryptophan metabolism_Homo sapiens_hsa003800.58270310
59Salivary secretion_Homo sapiens_hsa049700.57004154
60Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.55703312
61Maturity onset diabetes of the young_Homo sapiens_hsa049500.55582357
62Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.52245863
63Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.50877284
64Glutathione metabolism_Homo sapiens_hsa004800.49573501
65Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.48084258
66Influenza A_Homo sapiens_hsa051640.45558077
67Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.45302845
68Collecting duct acid secretion_Homo sapiens_hsa049660.43240323
69Nucleotide excision repair_Homo sapiens_hsa034200.40956786
70Cardiac muscle contraction_Homo sapiens_hsa042600.39485794
71Phagosome_Homo sapiens_hsa041450.38678182
72Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37760471
73Oocyte meiosis_Homo sapiens_hsa041140.37264789
74Regulation of autophagy_Homo sapiens_hsa041400.36304781
75Tuberculosis_Homo sapiens_hsa051520.34019280
76Fatty acid degradation_Homo sapiens_hsa000710.33709417
77Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32289666
78mRNA surveillance pathway_Homo sapiens_hsa030150.31820713
79Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.30263158
80Metabolic pathways_Homo sapiens_hsa011000.29521411
81Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.28047808
82Taste transduction_Homo sapiens_hsa047420.27962878
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.27898732
84Folate biosynthesis_Homo sapiens_hsa007900.26266322
85Cell cycle_Homo sapiens_hsa041100.25651953
86Glycerolipid metabolism_Homo sapiens_hsa005610.25331658
87Pyruvate metabolism_Homo sapiens_hsa006200.23751028
88beta-Alanine metabolism_Homo sapiens_hsa004100.23292555
89p53 signaling pathway_Homo sapiens_hsa041150.22859144
90Pentose and glucuronate interconversions_Homo sapiens_hsa000400.19793922
91Retinol metabolism_Homo sapiens_hsa008300.19683971
92Circadian entrainment_Homo sapiens_hsa047130.17994492
93Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.16878462
94Chemical carcinogenesis_Homo sapiens_hsa052040.15812337
95Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.15691134
96Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.14742584
97Morphine addiction_Homo sapiens_hsa050320.13566970
98GABAergic synapse_Homo sapiens_hsa047270.13233930
99Serotonergic synapse_Homo sapiens_hsa047260.11955832
100Starch and sucrose metabolism_Homo sapiens_hsa005000.10229179

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