

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | cullin deneddylation (GO:0010388) | 6.08902992 |
| 2 | protein deneddylation (GO:0000338) | 5.49704261 |
| 3 | prenylation (GO:0097354) | 5.19185465 |
| 4 | protein prenylation (GO:0018342) | 5.19185465 |
| 5 | respiratory chain complex IV assembly (GO:0008535) | 5.12334429 |
| 6 | synapsis (GO:0007129) | 5.12101908 |
| 7 | centriole replication (GO:0007099) | 4.91618805 |
| 8 | proteasome assembly (GO:0043248) | 4.83963623 |
| 9 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.79713989 |
| 10 | chaperone-mediated protein transport (GO:0072321) | 4.76212100 |
| 11 | negative regulation of mast cell activation (GO:0033004) | 4.58303255 |
| 12 | negative regulation of heart rate (GO:0010459) | 4.42617665 |
| 13 | DNA replication-dependent nucleosome organization (GO:0034723) | 4.33748432 |
| 14 | DNA replication-dependent nucleosome assembly (GO:0006335) | 4.33748432 |
| 15 | positive regulation of fibroblast migration (GO:0010763) | 4.30426738 |
| 16 | cytochrome complex assembly (GO:0017004) | 4.28774160 |
| 17 | water-soluble vitamin biosynthetic process (GO:0042364) | 4.14628006 |
| 18 | CENP-A containing nucleosome assembly (GO:0034080) | 4.10814821 |
| 19 | chromatin remodeling at centromere (GO:0031055) | 3.97287623 |
| 20 | deoxyribonucleoside triphosphate metabolic process (GO:0009200) | 3.77044137 |
| 21 | rRNA modification (GO:0000154) | 3.72555554 |
| 22 | regulation of urine volume (GO:0035809) | 3.65069218 |
| 23 | mature B cell differentiation involved in immune response (GO:0002313) | 3.53893133 |
| 24 | ATP synthesis coupled proton transport (GO:0015986) | 3.51730313 |
| 25 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.51730313 |
| 26 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.50018115 |
| 27 | regulation of circadian sleep/wake cycle (GO:0042749) | 3.47222073 |
| 28 | regulation of circadian sleep/wake cycle, sleep (GO:0045187) | 3.47222073 |
| 29 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class | 3.46117513 |
| 30 | phagocytosis, engulfment (GO:0006911) | 3.44222716 |
| 31 | negative regulation of membrane potential (GO:0045837) | 3.41979880 |
| 32 | negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147) | 3.41851488 |
| 33 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.40096436 |
| 34 | termination of RNA polymerase III transcription (GO:0006386) | 3.40096436 |
| 35 | DNA replication-independent nucleosome organization (GO:0034724) | 3.32923555 |
| 36 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.32923555 |
| 37 | transepithelial transport (GO:0070633) | 3.32221539 |
| 38 | inositol phosphate dephosphorylation (GO:0046855) | 3.31401264 |
| 39 | phosphorylated carbohydrate dephosphorylation (GO:0046838) | 3.31401264 |
| 40 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.28469119 |
| 41 | rRNA methylation (GO:0031167) | 3.27242011 |
| 42 | regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768) | 3.20703050 |
| 43 | protein neddylation (GO:0045116) | 3.20575356 |
| 44 | deoxyribose phosphate biosynthetic process (GO:0046385) | 3.20445855 |
| 45 | 2-deoxyribonucleotide biosynthetic process (GO:0009265) | 3.20445855 |
| 46 | histone exchange (GO:0043486) | 3.19587521 |
| 47 | mature B cell differentiation (GO:0002335) | 3.18301651 |
| 48 | DNA double-strand break processing (GO:0000729) | 3.17046766 |
| 49 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.16740795 |
| 50 | platelet dense granule organization (GO:0060155) | 3.16059166 |
| 51 | regulation of glucokinase activity (GO:0033131) | 3.13542508 |
| 52 | regulation of hexokinase activity (GO:1903299) | 3.13542508 |
| 53 | regulation of female gonad development (GO:2000194) | 3.12748373 |
| 54 | centriole assembly (GO:0098534) | 3.10287910 |
| 55 | regulation of DNA endoreduplication (GO:0032875) | 3.08950734 |
| 56 | regulation of meiosis I (GO:0060631) | 3.04169016 |
| 57 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.02511681 |
| 58 | vitamin biosynthetic process (GO:0009110) | 3.00972128 |
| 59 | positive regulation of T cell cytokine production (GO:0002726) | 3.00699417 |
| 60 | protein K6-linked ubiquitination (GO:0085020) | 3.00394758 |
| 61 | positive regulation of G1/S transition of mitotic cell cycle (GO:1900087) | 2.99261019 |
| 62 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 2.97063045 |
| 63 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 2.96714110 |
| 64 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 2.96714110 |
| 65 | positive regulation of cell cycle G1/S phase transition (GO:1902808) | 2.95618453 |
| 66 | regulation of cellular amino acid metabolic process (GO:0006521) | 2.95207169 |
| 67 | inositol phosphate catabolic process (GO:0071545) | 2.89983291 |
| 68 | regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531) | 2.88772059 |
| 69 | regulation of glomerular filtration (GO:0003093) | 2.87788263 |
| 70 | mitochondrial respiratory chain complex assembly (GO:0033108) | 2.85886600 |
| 71 | intra-S DNA damage checkpoint (GO:0031573) | 2.84108745 |
| 72 | circadian sleep/wake cycle process (GO:0022410) | 2.83684071 |
| 73 | neutrophil activation involved in immune response (GO:0002283) | 2.83198427 |
| 74 | pseudouridine synthesis (GO:0001522) | 2.82979046 |
| 75 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 2.81859099 |
| 76 | response to testosterone (GO:0033574) | 2.79154519 |
| 77 | intracellular protein transmembrane import (GO:0044743) | 2.78623280 |
| 78 | negative regulation of ligase activity (GO:0051352) | 2.77658113 |
| 79 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 2.77658113 |
| 80 | negative regulation of neurotransmitter secretion (GO:0046929) | 2.75058293 |
| 81 | regulation of mitochondrial translation (GO:0070129) | 2.73349242 |
| 82 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 2.73331207 |
| 83 | protein complex biogenesis (GO:0070271) | 2.72679310 |
| 84 | DNA catabolic process, exonucleolytic (GO:0000738) | 2.72446453 |
| 85 | regulation of RIG-I signaling pathway (GO:0039535) | 2.72082950 |
| 86 | histone H2A acetylation (GO:0043968) | 2.71706107 |
| 87 | aldehyde catabolic process (GO:0046185) | 2.71390094 |
| 88 | nucleosome assembly (GO:0006334) | 2.71260312 |
| 89 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 2.71173409 |
| 90 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 2.71173409 |
| 91 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 2.71173409 |
| 92 | S-adenosylmethionine metabolic process (GO:0046500) | 2.70552755 |
| 93 | deoxyribonucleotide biosynthetic process (GO:0009263) | 2.69655397 |
| 94 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 2.68684415 |
| 95 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 2.68684415 |
| 96 | C4-dicarboxylate transport (GO:0015740) | 2.66600620 |
| 97 | response to gravity (GO:0009629) | 2.66121089 |
| 98 | protein-DNA complex assembly (GO:0065004) | 2.65827113 |
| 99 | regulation of triglyceride catabolic process (GO:0010896) | 2.65402057 |
| 100 | regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | 2.65401125 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 5.41127310 |
| 2 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 4.59512156 |
| 3 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 4.28724698 |
| 4 | EZH2_22144423_ChIP-Seq_EOC_Human | 4.24871245 |
| 5 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.76561169 |
| 6 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.70974981 |
| 7 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.15284018 |
| 8 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.80303720 |
| 9 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.75021417 |
| 10 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.64314030 |
| 11 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.57655774 |
| 12 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.41713284 |
| 13 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.38450320 |
| 14 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 2.37979105 |
| 15 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.19257533 |
| 16 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 2.18832514 |
| 17 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.18649979 |
| 18 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.11193596 |
| 19 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.03640059 |
| 20 | VDR_22108803_ChIP-Seq_LS180_Human | 2.01882132 |
| 21 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.99623734 |
| 22 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 1.97231076 |
| 23 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.87959462 |
| 24 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.86466621 |
| 25 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.81088732 |
| 26 | FUS_26573619_Chip-Seq_HEK293_Human | 1.80161416 |
| 27 | EWS_26573619_Chip-Seq_HEK293_Human | 1.77002819 |
| 28 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 1.76652915 |
| 29 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 1.76295451 |
| 30 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.75502244 |
| 31 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.74132984 |
| 32 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.73931726 |
| 33 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.71747256 |
| 34 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.68563830 |
| 35 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.67569026 |
| 36 | E2F7_22180533_ChIP-Seq_HELA_Human | 1.65748481 |
| 37 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.59046135 |
| 38 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.58986140 |
| 39 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.58342588 |
| 40 | FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 1.56460157 |
| 41 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.55686890 |
| 42 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.53019624 |
| 43 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.51647795 |
| 44 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.50444806 |
| 45 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.49818124 |
| 46 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.49298740 |
| 47 | P300_19829295_ChIP-Seq_ESCs_Human | 1.49263313 |
| 48 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.45535856 |
| 49 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.44444817 |
| 50 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.43814764 |
| 51 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.41970724 |
| 52 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.41970724 |
| 53 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.36948700 |
| 54 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.36564852 |
| 55 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.32794794 |
| 56 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.30919176 |
| 57 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.29629177 |
| 58 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.29199721 |
| 59 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.26753013 |
| 60 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.25571759 |
| 61 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.23916613 |
| 62 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.16488484 |
| 63 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.13888982 |
| 64 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.12685859 |
| 65 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.12685859 |
| 66 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.11169185 |
| 67 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.10038178 |
| 68 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.06958299 |
| 69 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.05526254 |
| 70 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.03497397 |
| 71 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.03497397 |
| 72 | ERG_20517297_ChIP-Seq_VCAP_Human | 1.00993129 |
| 73 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 0.98627799 |
| 74 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 0.97991092 |
| 75 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.96938090 |
| 76 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 0.96446529 |
| 77 | SALL4_22934838_ChIP-ChIP_CD34+_Human | 0.96136829 |
| 78 | PHF8_20622853_ChIP-Seq_HELA_Human | 0.95923552 |
| 79 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.95308016 |
| 80 | AR_21572438_ChIP-Seq_LNCaP_Human | 0.92639760 |
| 81 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 0.92252979 |
| 82 | ELF5_23300383_ChIP-Seq_T47D_Human | 0.90716561 |
| 83 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 0.88110555 |
| 84 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.86797729 |
| 85 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 0.86389547 |
| 86 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 0.86188485 |
| 87 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 0.86026719 |
| 88 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 0.86026719 |
| 89 | NCOR_22424771_ChIP-Seq_293T_Human | 0.82187739 |
| 90 | RBPJ_21746931_ChIP-Seq_IB4_Human | 0.81602409 |
| 91 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 0.80633740 |
| 92 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.79988957 |
| 93 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 0.78943469 |
| 94 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 0.78586474 |
| 95 | GATA6_21074721_ChIP-Seq_CACO-2_Mouse | 0.78484654 |
| 96 | CBP_21632823_ChIP-Seq_H3396_Human | 0.77108219 |
| 97 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 0.76925717 |
| 98 | AR_25329375_ChIP-Seq_VCAP_Human | 0.76444647 |
| 99 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.76363833 |
| 100 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 0.76126369 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0006292_abnormal_olfactory_placode | 4.03795205 |
| 2 | MP0002736_abnormal_nociception_after | 3.34991161 |
| 3 | MP0003806_abnormal_nucleotide_metabolis | 3.14820163 |
| 4 | MP0002876_abnormal_thyroid_physiology | 3.09404645 |
| 5 | MP0006072_abnormal_retinal_apoptosis | 3.05399184 |
| 6 | MP0003718_maternal_effect | 2.94461920 |
| 7 | MP0005367_renal/urinary_system_phenotyp | 2.92604993 |
| 8 | MP0000516_abnormal_urinary_system | 2.92604993 |
| 9 | MP0003880_abnormal_central_pattern | 2.64014430 |
| 10 | MP0001188_hyperpigmentation | 2.57087618 |
| 11 | MP0002837_dystrophic_cardiac_calcinosis | 2.56413725 |
| 12 | MP0003011_delayed_dark_adaptation | 2.51191450 |
| 13 | MP0002396_abnormal_hematopoietic_system | 2.42187984 |
| 14 | MP0003724_increased_susceptibility_to | 2.34755928 |
| 15 | MP0001968_abnormal_touch/_nociception | 2.33762998 |
| 16 | MP0002234_abnormal_pharynx_morphology | 2.12225638 |
| 17 | MP0003890_abnormal_embryonic-extraembry | 2.00372798 |
| 18 | MP0003646_muscle_fatigue | 1.98744183 |
| 19 | MP0003123_paternal_imprinting | 1.91713630 |
| 20 | MP0008875_abnormal_xenobiotic_pharmacok | 1.89344578 |
| 21 | MP0001835_abnormal_antigen_presentation | 1.87903481 |
| 22 | MP0005075_abnormal_melanosome_morpholog | 1.77053163 |
| 23 | MP0003195_calcinosis | 1.75063347 |
| 24 | MP0009046_muscle_twitch | 1.72617163 |
| 25 | MP0005645_abnormal_hypothalamus_physiol | 1.70686309 |
| 26 | MP0003121_genomic_imprinting | 1.57161062 |
| 27 | MP0005671_abnormal_response_to | 1.52769838 |
| 28 | MP0003786_premature_aging | 1.52494228 |
| 29 | MP0001905_abnormal_dopamine_level | 1.49430521 |
| 30 | MP0005253_abnormal_eye_physiology | 1.49066239 |
| 31 | MP0005174_abnormal_tail_pigmentation | 1.47344828 |
| 32 | MP0002138_abnormal_hepatobiliary_system | 1.45553782 |
| 33 | MP0005408_hypopigmentation | 1.43174572 |
| 34 | MP0010094_abnormal_chromosome_stability | 1.41145784 |
| 35 | MP0005389_reproductive_system_phenotype | 1.39356139 |
| 36 | MP0004957_abnormal_blastocyst_morpholog | 1.37318434 |
| 37 | MP0010368_abnormal_lymphatic_system | 1.35906310 |
| 38 | MP0005646_abnormal_pituitary_gland | 1.34855362 |
| 39 | MP0001545_abnormal_hematopoietic_system | 1.34350520 |
| 40 | MP0005397_hematopoietic_system_phenotyp | 1.34350520 |
| 41 | MP0002735_abnormal_chemical_nociception | 1.25389538 |
| 42 | MP0000372_irregular_coat_pigmentation | 1.25362242 |
| 43 | MP0008004_abnormal_stomach_pH | 1.23362215 |
| 44 | MP0003136_yellow_coat_color | 1.23301344 |
| 45 | MP0008932_abnormal_embryonic_tissue | 1.23180645 |
| 46 | MP0003122_maternal_imprinting | 1.22169944 |
| 47 | MP0001919_abnormal_reproductive_system | 1.21123445 |
| 48 | MP0000613_abnormal_salivary_gland | 1.17207616 |
| 49 | MP0003787_abnormal_imprinting | 1.16319053 |
| 50 | MP0000538_abnormal_urinary_bladder | 1.14073916 |
| 51 | MP0000049_abnormal_middle_ear | 1.14057424 |
| 52 | MP0004142_abnormal_muscle_tone | 1.12749711 |
| 53 | MP0002148_abnormal_hypersensitivity_rea | 1.11150034 |
| 54 | MP0008775_abnormal_heart_ventricle | 1.10552361 |
| 55 | MP0003119_abnormal_digestive_system | 1.06770916 |
| 56 | MP0002938_white_spotting | 1.05619262 |
| 57 | MP0004215_abnormal_myocardial_fiber | 1.00759977 |
| 58 | MP0001879_abnormal_lymphatic_vessel | 0.98064364 |
| 59 | MP0003448_altered_tumor_morphology | 0.97731960 |
| 60 | MP0002160_abnormal_reproductive_system | 0.97614172 |
| 61 | MP0003755_abnormal_palate_morphology | 0.95793406 |
| 62 | MP0000749_muscle_degeneration | 0.92966163 |
| 63 | MP0001177_atelectasis | 0.92532641 |
| 64 | MP0005332_abnormal_amino_acid | 0.92098752 |
| 65 | MP0008789_abnormal_olfactory_epithelium | 0.91417297 |
| 66 | MP0001119_abnormal_female_reproductive | 0.89549832 |
| 67 | MP0006036_abnormal_mitochondrial_physio | 0.89191039 |
| 68 | MP0002277_abnormal_respiratory_mucosa | 0.89137159 |
| 69 | MP0002166_altered_tumor_susceptibility | 0.88876858 |
| 70 | MP0010155_abnormal_intestine_physiology | 0.88780846 |
| 71 | MP0003937_abnormal_limbs/digits/tail_de | 0.87747266 |
| 72 | MP0002102_abnormal_ear_morphology | 0.86987783 |
| 73 | MP0009785_altered_susceptibility_to | 0.86721523 |
| 74 | MP0004084_abnormal_cardiac_muscle | 0.85797235 |
| 75 | MP0002163_abnormal_gland_morphology | 0.85406586 |
| 76 | MP0002090_abnormal_vision | 0.85232034 |
| 77 | MP0001756_abnormal_urination | 0.84993021 |
| 78 | MP0001293_anophthalmia | 0.83218944 |
| 79 | MP0002095_abnormal_skin_pigmentation | 0.82167099 |
| 80 | MP0000465_gastrointestinal_hemorrhage | 0.81625702 |
| 81 | MP0002210_abnormal_sex_determination | 0.79155444 |
| 82 | MP0001970_abnormal_pain_threshold | 0.78534074 |
| 83 | MP0005410_abnormal_fertilization | 0.76775295 |
| 84 | MP0008058_abnormal_DNA_repair | 0.76100225 |
| 85 | MP0009250_abnormal_appendicular_skeleto | 0.76037688 |
| 86 | MP0000653_abnormal_sex_gland | 0.74583117 |
| 87 | MP0000631_abnormal_neuroendocrine_gland | 0.74161512 |
| 88 | MP0005551_abnormal_eye_electrophysiolog | 0.74099364 |
| 89 | MP0009745_abnormal_behavioral_response | 0.71484641 |
| 90 | MP0002019_abnormal_tumor_incidence | 0.71371255 |
| 91 | MP0001346_abnormal_lacrimal_gland | 0.69872824 |
| 92 | MP0001501_abnormal_sleep_pattern | 0.69092997 |
| 93 | MP0001191_abnormal_skin_condition | 0.67941896 |
| 94 | MP0001764_abnormal_homeostasis | 0.66746415 |
| 95 | MP0009764_decreased_sensitivity_to | 0.66054184 |
| 96 | MP0005195_abnormal_posterior_eye | 0.65244446 |
| 97 | MP0005395_other_phenotype | 0.65221594 |
| 98 | MP0002928_abnormal_bile_duct | 0.65009725 |
| 99 | MP0002006_tumorigenesis | 0.63870121 |
| 100 | MP0001145_abnormal_male_reproductive | 0.62928709 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Metaphyseal dysplasia (HP:0100255) | 4.77742908 |
| 2 | Hepatocellular necrosis (HP:0001404) | 4.24462006 |
| 3 | Hepatic necrosis (HP:0002605) | 3.93450850 |
| 4 | Aplastic anemia (HP:0001915) | 3.72968106 |
| 5 | Increased CSF lactate (HP:0002490) | 3.61685397 |
| 6 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 3.59242353 |
| 7 | Lipid accumulation in hepatocytes (HP:0006561) | 3.53739876 |
| 8 | Mitochondrial inheritance (HP:0001427) | 3.51566999 |
| 9 | Abnormality of the preputium (HP:0100587) | 3.41618694 |
| 10 | Limb hypertonia (HP:0002509) | 3.41014456 |
| 11 | Chromsome breakage (HP:0040012) | 3.40699397 |
| 12 | Increased hepatocellular lipid droplets (HP:0006565) | 3.34284111 |
| 13 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 3.29617092 |
| 14 | Meckel diverticulum (HP:0002245) | 3.19544830 |
| 15 | Hyperglycinemia (HP:0002154) | 3.11316065 |
| 16 | Clubbing of toes (HP:0100760) | 3.10969450 |
| 17 | Absent frontal sinuses (HP:0002688) | 3.08232371 |
| 18 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 3.06070201 |
| 19 | Abnormality of the ileum (HP:0001549) | 3.02952148 |
| 20 | Hypoglycemic seizures (HP:0002173) | 2.95012038 |
| 21 | Short tibia (HP:0005736) | 2.91458139 |
| 22 | Glossoptosis (HP:0000162) | 2.91402485 |
| 23 | Progressive macrocephaly (HP:0004481) | 2.85462739 |
| 24 | Aplasia/Hypoplasia of the frontal sinuses (HP:0009119) | 2.78949592 |
| 25 | Abnormality of the costochondral junction (HP:0000919) | 2.77487798 |
| 26 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 2.68591794 |
| 27 | Abnormality of chromosome stability (HP:0003220) | 2.66266392 |
| 28 | Neonatal respiratory distress (HP:0002643) | 2.65669081 |
| 29 | Renal Fanconi syndrome (HP:0001994) | 2.64102937 |
| 30 | Exercise-induced muscle cramps (HP:0003710) | 2.61032740 |
| 31 | Alveolar cell carcinoma (HP:0006519) | 2.60062536 |
| 32 | Abnormality of the phalanges of the 2nd finger (HP:0009541) | 2.57558134 |
| 33 | Acute encephalopathy (HP:0006846) | 2.56214554 |
| 34 | Exertional dyspnea (HP:0002875) | 2.54604710 |
| 35 | Congenital, generalized hypertrichosis (HP:0004540) | 2.54306606 |
| 36 | Abnormal lung lobation (HP:0002101) | 2.52198788 |
| 37 | Dyschromatopsia (HP:0007641) | 2.46677636 |
| 38 | Abnormality of the anterior horn cell (HP:0006802) | 2.44653239 |
| 39 | Degeneration of anterior horn cells (HP:0002398) | 2.44653239 |
| 40 | Small intestinal stenosis (HP:0012848) | 2.41784943 |
| 41 | Duodenal stenosis (HP:0100867) | 2.41784943 |
| 42 | Abnormal sex determination (HP:0012244) | 2.40765511 |
| 43 | Sex reversal (HP:0012245) | 2.40765511 |
| 44 | Acute necrotizing encephalopathy (HP:0006965) | 2.38879168 |
| 45 | Nephroblastoma (Wilms tumor) (HP:0002667) | 2.38068947 |
| 46 | Hypokinesia (HP:0002375) | 2.36395623 |
| 47 | Microglossia (HP:0000171) | 2.28680136 |
| 48 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 2.28491082 |
| 49 | Increased serum lactate (HP:0002151) | 2.25345377 |
| 50 | Embryonal renal neoplasm (HP:0011794) | 2.25326775 |
| 51 | Abnormality of the frontal sinuses (HP:0002687) | 2.20090418 |
| 52 | Short middle phalanx of the 5th finger (HP:0004220) | 2.17956715 |
| 53 | Neoplasm of the tracheobronchial system (HP:0100552) | 2.15629854 |
| 54 | 3-Methylglutaconic aciduria (HP:0003535) | 2.14103865 |
| 55 | Progressive microcephaly (HP:0000253) | 2.13309950 |
| 56 | Neoplasm of the adrenal cortex (HP:0100641) | 2.10074505 |
| 57 | Hemiparesis (HP:0001269) | 2.10002309 |
| 58 | Respiratory failure (HP:0002878) | 2.09754202 |
| 59 | Lactic acidosis (HP:0003128) | 2.09344512 |
| 60 | Global brain atrophy (HP:0002283) | 2.09310605 |
| 61 | Abnormality of the duodenum (HP:0002246) | 2.09232502 |
| 62 | Hyperglycinuria (HP:0003108) | 2.06837677 |
| 63 | Abnormality of the axillary hair (HP:0100134) | 2.06058231 |
| 64 | Abnormality of secondary sexual hair (HP:0009888) | 2.06058231 |
| 65 | Subcapsular cataract (HP:0000523) | 2.06004495 |
| 66 | Hypoglycemic coma (HP:0001325) | 2.05566635 |
| 67 | Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161) | 2.04300374 |
| 68 | Myoglobinuria (HP:0002913) | 2.03227436 |
| 69 | Microretrognathia (HP:0000308) | 2.03006755 |
| 70 | Stenosis of the external auditory canal (HP:0000402) | 2.02712421 |
| 71 | Poor suck (HP:0002033) | 1.99736039 |
| 72 | Hyperinsulinemic hypoglycemia (HP:0000825) | 1.99036076 |
| 73 | Decreased central vision (HP:0007663) | 1.97536899 |
| 74 | Aplasia/Hypoplasia involving the sinuses (HP:0009120) | 1.95707547 |
| 75 | Abnormality of the middle phalanx of the 5th finger (HP:0004219) | 1.95573660 |
| 76 | Testicular neoplasm (HP:0010788) | 1.95156084 |
| 77 | CNS demyelination (HP:0007305) | 1.93912874 |
| 78 | Congenital ichthyosiform erythroderma (HP:0007431) | 1.92766051 |
| 79 | Abolished electroretinogram (ERG) (HP:0000550) | 1.90794412 |
| 80 | Aplasia/Hypoplasia of the tongue (HP:0010295) | 1.90447308 |
| 81 | Cerebral edema (HP:0002181) | 1.89734930 |
| 82 | Abnormal mitochondria in muscle tissue (HP:0008316) | 1.89329826 |
| 83 | Abnormal epiphyseal ossification (HP:0010656) | 1.88072337 |
| 84 | Delayed epiphyseal ossification (HP:0002663) | 1.86511505 |
| 85 | Pancytopenia (HP:0001876) | 1.86431039 |
| 86 | Cutaneous melanoma (HP:0012056) | 1.86075369 |
| 87 | Arteriovenous malformation (HP:0100026) | 1.85385508 |
| 88 | Abnormality of serine family amino acid metabolism (HP:0010894) | 1.84109416 |
| 89 | Abnormality of glycine metabolism (HP:0010895) | 1.84109416 |
| 90 | Supernumerary spleens (HP:0009799) | 1.82201954 |
| 91 | Dry hair (HP:0011359) | 1.81971647 |
| 92 | Male pseudohermaphroditism (HP:0000037) | 1.81598651 |
| 93 | Flat capital femoral epiphysis (HP:0003370) | 1.81403777 |
| 94 | Stomach cancer (HP:0012126) | 1.80874505 |
| 95 | Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376) | 1.79385705 |
| 96 | Bundle branch block (HP:0011710) | 1.78319034 |
| 97 | Colon cancer (HP:0003003) | 1.78246868 |
| 98 | Increased intramyocellular lipid droplets (HP:0012240) | 1.78206064 |
| 99 | Irregular epiphyses (HP:0010582) | 1.77284107 |
| 100 | Abnormality of methionine metabolism (HP:0010901) | 1.76244227 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | NUAK1 | 4.48783224 |
| 2 | TIE1 | 4.32421694 |
| 3 | CDK19 | 3.80110403 |
| 4 | CDC7 | 2.84568471 |
| 5 | OXSR1 | 2.79023407 |
| 6 | BCKDK | 2.76129727 |
| 7 | BMPR2 | 2.69843674 |
| 8 | BUB1 | 2.66428285 |
| 9 | EIF2AK3 | 2.63665699 |
| 10 | MST4 | 2.62679543 |
| 11 | MAP3K12 | 2.62211069 |
| 12 | ACVR1B | 2.45916875 |
| 13 | FRK | 2.44474025 |
| 14 | TLK1 | 2.34695322 |
| 15 | STK24 | 2.31971852 |
| 16 | ZAK | 2.29223441 |
| 17 | MKNK2 | 2.27448950 |
| 18 | TNIK | 1.96059408 |
| 19 | PRKD3 | 1.89872035 |
| 20 | MAP4K2 | 1.88541180 |
| 21 | BMPR1B | 1.87185964 |
| 22 | STK39 | 1.63098742 |
| 23 | TAOK3 | 1.62574288 |
| 24 | FLT3 | 1.62207583 |
| 25 | PLK4 | 1.54720100 |
| 26 | GRK1 | 1.40421120 |
| 27 | VRK1 | 1.38803434 |
| 28 | WNK3 | 1.34730371 |
| 29 | SIK3 | 1.34242992 |
| 30 | MKNK1 | 1.30997550 |
| 31 | WEE1 | 1.28852381 |
| 32 | STK16 | 1.27277574 |
| 33 | ERBB3 | 1.10956622 |
| 34 | TRPM7 | 1.01739198 |
| 35 | VRK2 | 1.00739785 |
| 36 | EIF2AK1 | 0.97872862 |
| 37 | PLK2 | 0.96741434 |
| 38 | TEC | 0.96440479 |
| 39 | AKT3 | 0.93746538 |
| 40 | EIF2AK2 | 0.91318970 |
| 41 | RPS6KA5 | 0.87611040 |
| 42 | WNK1 | 0.85446174 |
| 43 | KIT | 0.84997861 |
| 44 | NEK1 | 0.83922931 |
| 45 | CDK8 | 0.83587573 |
| 46 | TGFBR1 | 0.83269432 |
| 47 | MAPK13 | 0.82863754 |
| 48 | PHKG1 | 0.82638089 |
| 49 | PHKG2 | 0.82638089 |
| 50 | MYLK | 0.82378496 |
| 51 | CSNK1G2 | 0.80452748 |
| 52 | MARK3 | 0.79619028 |
| 53 | TRIM28 | 0.79046581 |
| 54 | DYRK2 | 0.78756793 |
| 55 | STK38L | 0.78323562 |
| 56 | CSNK1G1 | 0.78080384 |
| 57 | CSNK1G3 | 0.76816641 |
| 58 | STK3 | 0.76663303 |
| 59 | CSF1R | 0.73845558 |
| 60 | CSNK1A1L | 0.73034983 |
| 61 | PLK3 | 0.71033060 |
| 62 | PAK4 | 0.62854785 |
| 63 | NME2 | 0.62764801 |
| 64 | AURKA | 0.62487364 |
| 65 | PLK1 | 0.59010146 |
| 66 | MAPKAPK5 | 0.57867939 |
| 67 | ADRBK2 | 0.56342161 |
| 68 | CDK7 | 0.54244614 |
| 69 | MINK1 | 0.51941379 |
| 70 | PTK2B | 0.50460293 |
| 71 | IKBKB | 0.50030094 |
| 72 | DAPK3 | 0.48551822 |
| 73 | WNK4 | 0.45335393 |
| 74 | BRSK2 | 0.43901163 |
| 75 | MAPKAPK3 | 0.43662558 |
| 76 | DDR2 | 0.41083063 |
| 77 | CHUK | 0.40261697 |
| 78 | AURKB | 0.38901942 |
| 79 | PAK1 | 0.38638151 |
| 80 | ABL2 | 0.36320438 |
| 81 | ERBB4 | 0.34541580 |
| 82 | PNCK | 0.33307899 |
| 83 | CSNK2A1 | 0.31681587 |
| 84 | CSNK1D | 0.28790587 |
| 85 | OBSCN | 0.27964054 |
| 86 | CHEK2 | 0.27943841 |
| 87 | PIM2 | 0.27077441 |
| 88 | INSRR | 0.26718522 |
| 89 | ROCK1 | 0.26489248 |
| 90 | FGFR2 | 0.26097922 |
| 91 | BRAF | 0.25457234 |
| 92 | LATS1 | 0.24823550 |
| 93 | LRRK2 | 0.23662789 |
| 94 | GRK5 | 0.23225569 |
| 95 | ABL1 | 0.22592013 |
| 96 | PRKG1 | 0.19569490 |
| 97 | CSNK2A2 | 0.17834787 |
| 98 | HCK | 0.17716370 |
| 99 | CAMK2D | 0.16574013 |
| 100 | ILK | 0.16571741 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Asthma_Homo sapiens_hsa05310 | 5.10332159 |
| 2 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 4.29386344 |
| 3 | Allograft rejection_Homo sapiens_hsa05330 | 3.83910015 |
| 4 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 3.54523450 |
| 5 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 3.34150998 |
| 6 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 3.33292509 |
| 7 | Graft-versus-host disease_Homo sapiens_hsa05332 | 3.32356919 |
| 8 | Proteasome_Homo sapiens_hsa03050 | 2.86163700 |
| 9 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 2.26234662 |
| 10 | Sulfur metabolism_Homo sapiens_hsa00920 | 2.24939989 |
| 11 | Viral myocarditis_Homo sapiens_hsa05416 | 2.19821571 |
| 12 | RNA polymerase_Homo sapiens_hsa03020 | 2.07895040 |
| 13 | Protein export_Homo sapiens_hsa03060 | 2.06679838 |
| 14 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.03939179 |
| 15 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.83816553 |
| 16 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 1.82724193 |
| 17 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.81941445 |
| 18 | Leishmaniasis_Homo sapiens_hsa05140 | 1.80743204 |
| 19 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.73649872 |
| 20 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.59229665 |
| 21 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.57906949 |
| 22 | Parkinsons disease_Homo sapiens_hsa05012 | 1.57848369 |
| 23 | Alcoholism_Homo sapiens_hsa05034 | 1.56503499 |
| 24 | DNA replication_Homo sapiens_hsa03030 | 1.56189074 |
| 25 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.46413022 |
| 26 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.42911912 |
| 27 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.38171185 |
| 28 | Homologous recombination_Homo sapiens_hsa03440 | 1.33523008 |
| 29 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.30756531 |
| 30 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.23301970 |
| 31 | Mismatch repair_Homo sapiens_hsa03430 | 1.18315443 |
| 32 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.07128683 |
| 33 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.05647728 |
| 34 | Huntingtons disease_Homo sapiens_hsa05016 | 1.05519865 |
| 35 | Ribosome_Homo sapiens_hsa03010 | 1.04445629 |
| 36 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.02515353 |
| 37 | Spliceosome_Homo sapiens_hsa03040 | 1.01381667 |
| 38 | Alzheimers disease_Homo sapiens_hsa05010 | 0.98176217 |
| 39 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.94491449 |
| 40 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.93407423 |
| 41 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.92426025 |
| 42 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.88327785 |
| 43 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.86912177 |
| 44 | RNA degradation_Homo sapiens_hsa03018 | 0.84922875 |
| 45 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.82537210 |
| 46 | Base excision repair_Homo sapiens_hsa03410 | 0.82242719 |
| 47 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.81974273 |
| 48 | Phototransduction_Homo sapiens_hsa04744 | 0.81551588 |
| 49 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.76826167 |
| 50 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.75782405 |
| 51 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.71024140 |
| 52 | Basal transcription factors_Homo sapiens_hsa03022 | 0.68445191 |
| 53 | Purine metabolism_Homo sapiens_hsa00230 | 0.68251048 |
| 54 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.66312434 |
| 55 | RNA transport_Homo sapiens_hsa03013 | 0.65912051 |
| 56 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.65332716 |
| 57 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.59562382 |
| 58 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.58270310 |
| 59 | Salivary secretion_Homo sapiens_hsa04970 | 0.57004154 |
| 60 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.55703312 |
| 61 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.55582357 |
| 62 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.52245863 |
| 63 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.50877284 |
| 64 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.49573501 |
| 65 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.48084258 |
| 66 | Influenza A_Homo sapiens_hsa05164 | 0.45558077 |
| 67 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.45302845 |
| 68 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.43240323 |
| 69 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.40956786 |
| 70 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.39485794 |
| 71 | Phagosome_Homo sapiens_hsa04145 | 0.38678182 |
| 72 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.37760471 |
| 73 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.37264789 |
| 74 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.36304781 |
| 75 | Tuberculosis_Homo sapiens_hsa05152 | 0.34019280 |
| 76 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.33709417 |
| 77 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.32289666 |
| 78 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.31820713 |
| 79 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.30263158 |
| 80 | Metabolic pathways_Homo sapiens_hsa01100 | 0.29521411 |
| 81 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.28047808 |
| 82 | Taste transduction_Homo sapiens_hsa04742 | 0.27962878 |
| 83 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.27898732 |
| 84 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.26266322 |
| 85 | Cell cycle_Homo sapiens_hsa04110 | 0.25651953 |
| 86 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.25331658 |
| 87 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.23751028 |
| 88 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.23292555 |
| 89 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.22859144 |
| 90 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.19793922 |
| 91 | Retinol metabolism_Homo sapiens_hsa00830 | 0.19683971 |
| 92 | Circadian entrainment_Homo sapiens_hsa04713 | 0.17994492 |
| 93 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.16878462 |
| 94 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.15812337 |
| 95 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.15691134 |
| 96 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.14742584 |
| 97 | Morphine addiction_Homo sapiens_hsa05032 | 0.13566970 |
| 98 | GABAergic synapse_Homo sapiens_hsa04727 | 0.13233930 |
| 99 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.11955832 |
| 100 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.10229179 |

