DPH5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a component of the diphthamide synthesis pathway. Diphthamide is a post-translationally modified histidine residue found only on translation elongation factor 2. It is conserved from archaebacteria to humans, and is targeted by diphtheria toxin and Pseudomonas exotoxin A to halt cellular protein synthesis. The yeast and Chinese hamster homologs of this protein catalyze the trimethylation of the histidine residue on elongation factor 2, resulting in a diphthine moiety that is subsequently amidated to yield diphthamide. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.64273057
2DNA deamination (GO:0045006)4.93375032
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.51744034
4proteasome assembly (GO:0043248)4.19171873
5DNA double-strand break processing (GO:0000729)3.94829015
6ribosomal small subunit biogenesis (GO:0042274)3.92402203
7maturation of SSU-rRNA (GO:0030490)3.91658237
8establishment of protein localization to mitochondrial membrane (GO:0090151)3.91366113
9ATP synthesis coupled proton transport (GO:0015986)3.77521960
10energy coupled proton transport, down electrochemical gradient (GO:0015985)3.77521960
11transcription elongation from RNA polymerase III promoter (GO:0006385)3.74506595
12termination of RNA polymerase III transcription (GO:0006386)3.74506595
13DNA replication checkpoint (GO:0000076)3.70915003
14histone exchange (GO:0043486)3.69588708
15purine nucleobase biosynthetic process (GO:0009113)3.68261893
16establishment of integrated proviral latency (GO:0075713)3.68067693
17deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.64968942
18viral transcription (GO:0019083)3.55647345
19ribosomal large subunit biogenesis (GO:0042273)3.52907383
20nucleobase biosynthetic process (GO:0046112)3.48113913
21telomere maintenance via semi-conservative replication (GO:0032201)3.47528437
22ribonucleoprotein complex biogenesis (GO:0022613)3.45840551
23translational termination (GO:0006415)3.44406003
24ribosome assembly (GO:0042255)3.41357793
25replication fork processing (GO:0031297)3.41082423
26cullin deneddylation (GO:0010388)3.39833379
27DNA replication-independent nucleosome organization (GO:0034724)3.36404049
28DNA replication-independent nucleosome assembly (GO:0006336)3.36404049
29mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.36285066
30pseudouridine synthesis (GO:0001522)3.34581123
31chaperone-mediated protein transport (GO:0072321)3.30675150
32ribosome biogenesis (GO:0042254)3.28404250
33tRNA methylation (GO:0030488)3.27880709
34SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.25916842
35resolution of meiotic recombination intermediates (GO:0000712)3.22515602
367-methylguanosine mRNA capping (GO:0006370)3.22208336
37iron-sulfur cluster assembly (GO:0016226)3.20665183
38metallo-sulfur cluster assembly (GO:0031163)3.20665183
39respiratory chain complex IV assembly (GO:0008535)3.19901636
40cotranslational protein targeting to membrane (GO:0006613)3.19571647
417-methylguanosine RNA capping (GO:0009452)3.19042526
42RNA capping (GO:0036260)3.19042526
43telomere maintenance via recombination (GO:0000722)3.18848314
44termination of RNA polymerase I transcription (GO:0006363)3.15934948
45CENP-A containing nucleosome assembly (GO:0034080)3.15776167
46regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.15598015
47regulation of mitotic spindle checkpoint (GO:1903504)3.15598015
48rRNA modification (GO:0000154)3.14593040
49protein targeting to ER (GO:0045047)3.13716662
50protein localization to kinetochore (GO:0034501)3.12105263
51DNA strand elongation (GO:0022616)3.11192826
52rRNA processing (GO:0006364)3.10847872
53IMP metabolic process (GO:0046040)3.09866356
54transcription elongation from RNA polymerase I promoter (GO:0006362)3.09720450
55respiratory electron transport chain (GO:0022904)3.08972286
56protein deneddylation (GO:0000338)3.08258864
57regulation of helicase activity (GO:0051095)3.08145369
58protein neddylation (GO:0045116)3.07424777
59cellular component biogenesis (GO:0044085)3.06981436
60DNA strand elongation involved in DNA replication (GO:0006271)3.06756645
61nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.06188736
62DNA ligation (GO:0006266)3.05708908
63negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.05627839
64translational elongation (GO:0006414)3.05624193
65exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.05582998
66protein K6-linked ubiquitination (GO:0085020)3.03761563
67synapsis (GO:0007129)3.02461506
68electron transport chain (GO:0022900)3.01636475
69negative regulation of DNA-dependent DNA replication (GO:2000104)3.01413380
70transcription from RNA polymerase I promoter (GO:0006360)3.01361679
71rRNA metabolic process (GO:0016072)3.00958023
72mitotic metaphase plate congression (GO:0007080)3.00182960
73RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.99386270
74tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.99386270
75protein localization to endoplasmic reticulum (GO:0070972)2.99068568
76telomere maintenance via telomere lengthening (GO:0010833)2.98379126
77viral mRNA export from host cell nucleus (GO:0046784)2.98154125
78oxidative phosphorylation (GO:0006119)2.97958239
79mitochondrial RNA metabolic process (GO:0000959)2.97501289
80antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.97377579
81transcription-coupled nucleotide-excision repair (GO:0006283)2.95007728
82water-soluble vitamin biosynthetic process (GO:0042364)2.94443729
83establishment of protein localization to endoplasmic reticulum (GO:0072599)2.93994311
84chromatin remodeling at centromere (GO:0031055)2.93276264
85signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.92227592
86signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.92227592
87signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.92227592
88spindle checkpoint (GO:0031577)2.92073328
89histone mRNA metabolic process (GO:0008334)2.91087063
90DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.90731815
91protein targeting to mitochondrion (GO:0006626)2.90189750
92inner mitochondrial membrane organization (GO:0007007)2.89882589
93translation (GO:0006412)2.88378631
94mitotic spindle checkpoint (GO:0071174)2.88094934
95DNA replication-dependent nucleosome organization (GO:0034723)2.87948763
96DNA replication-dependent nucleosome assembly (GO:0006335)2.87948763
97positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.87730071
98intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.87724534
99signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.87724534
100rRNA methylation (GO:0031167)2.86765038
101antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.85136698
102deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.84813335
103regulation of mitochondrial translation (GO:0070129)2.84497128
104protein complex biogenesis (GO:0070271)2.84412249
105mitotic recombination (GO:0006312)2.84247149
106cytochrome complex assembly (GO:0017004)2.82953510
107positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.81374572
108mitochondrial respiratory chain complex I assembly (GO:0032981)2.80868843
109NADH dehydrogenase complex assembly (GO:0010257)2.80868843
110mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.80868843
111regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.80705007
112translational initiation (GO:0006413)2.78683503
113RNA-dependent DNA replication (GO:0006278)2.78464141
114signal transduction involved in DNA damage checkpoint (GO:0072422)2.77373770
115signal transduction involved in DNA integrity checkpoint (GO:0072401)2.77373770
116signal transduction involved in cell cycle checkpoint (GO:0072395)2.77369566
117DNA replication initiation (GO:0006270)2.77306227
118tRNA modification (GO:0006400)2.77087636
119DNA damage response, detection of DNA damage (GO:0042769)2.76057962
120negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.74776503
121negative regulation of ligase activity (GO:0051352)2.74776503
122regulation of cellular amino acid metabolic process (GO:0006521)2.73889593
123transcription initiation from RNA polymerase I promoter (GO:0006361)2.72193494
124regulation of nuclear cell cycle DNA replication (GO:0033262)2.70823967
125tRNA processing (GO:0008033)2.69612084
126viral life cycle (GO:0019058)2.69582373
127cellular protein complex disassembly (GO:0043624)2.68344166
128L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.68155866
129anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.66886109
130formation of translation preinitiation complex (GO:0001731)2.66229452
131ncRNA processing (GO:0034470)2.65710029
132nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.64273710
133RNA methylation (GO:0001510)2.62778500
134IMP biosynthetic process (GO:0006188)2.62700733
135antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.62541272
136mitochondrial respiratory chain complex assembly (GO:0033108)2.61187069
137kinetochore organization (GO:0051383)2.60784172
138maturation of 5.8S rRNA (GO:0000460)2.60300535
139regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.60232115
140kinetochore assembly (GO:0051382)2.59557326
141regulation of double-strand break repair via homologous recombination (GO:0010569)2.59018491
142nucleotide-excision repair, DNA gap filling (GO:0006297)2.58874166
143DNA catabolic process, exonucleolytic (GO:0000738)2.58153747
144spliceosomal snRNP assembly (GO:0000387)2.57567497
145platelet dense granule organization (GO:0060155)2.54953409

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.40472232
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.02258026
3ELF1_17652178_ChIP-ChIP_JURKAT_Human3.80362160
4* MYC_18555785_ChIP-Seq_MESCs_Mouse3.56300670
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.55377209
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.54768279
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.53731798
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.37938930
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.90603572
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.78480015
11* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.73528864
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.70368487
13VDR_23849224_ChIP-Seq_CD4+_Human2.69301381
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.66263301
15* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.56790066
16* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.56466155
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.51847783
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.50911916
19SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.48968087
20* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.46821366
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.44801691
22NOTCH1_21737748_ChIP-Seq_TLL_Human2.44216440
23SRF_21415370_ChIP-Seq_HL-1_Mouse2.43161893
24CREB1_15753290_ChIP-ChIP_HEK293T_Human2.39189013
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.37053110
26FOXP3_21729870_ChIP-Seq_TREG_Human2.33821684
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.30677142
28ELK1_19687146_ChIP-ChIP_HELA_Human2.26963731
29FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.20971585
30FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.20326610
31SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.13517949
32* HOXB4_20404135_ChIP-ChIP_EML_Mouse2.08588084
33* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.08505274
34MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.03765988
35SALL1_21062744_ChIP-ChIP_HESCs_Human2.03509296
36* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.00711068
37* DCP1A_22483619_ChIP-Seq_HELA_Human1.96439588
38IRF8_22096565_ChIP-ChIP_GC-B_Human1.93142242
39YY1_21170310_ChIP-Seq_MESCs_Mouse1.92787166
40FUS_26573619_Chip-Seq_HEK293_Human1.89378563
41TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.86214371
42E2F1_18555785_ChIP-Seq_MESCs_Mouse1.84502489
43KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.83548286
44THAP11_20581084_ChIP-Seq_MESCs_Mouse1.83334463
45NELFA_20434984_ChIP-Seq_ESCs_Mouse1.81377697
46XRN2_22483619_ChIP-Seq_HELA_Human1.77383627
47IRF8_21731497_ChIP-ChIP_J774_Mouse1.76999218
48FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.75474767
49ZNF274_21170338_ChIP-Seq_K562_Hela1.75364649
50ERG_20887958_ChIP-Seq_HPC-7_Mouse1.73937113
51TTF2_22483619_ChIP-Seq_HELA_Human1.73587620
52MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.73529802
53PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.68549193
54PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67716059
55YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.67695032
56GABP_19822575_ChIP-Seq_HepG2_Human1.61570218
57SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.59211457
58VDR_22108803_ChIP-Seq_LS180_Human1.53535678
59ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.52836549
60SPI1_23547873_ChIP-Seq_NB4_Human1.51316576
61MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.48209344
62* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.46145959
63IGF1R_20145208_ChIP-Seq_DFB_Human1.45166883
64POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.42821062
65AR_21909140_ChIP-Seq_LNCAP_Human1.42768171
66MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.38773182
67RBPJ_22232070_ChIP-Seq_NCS_Mouse1.33590435
68IRF1_19129219_ChIP-ChIP_H3396_Human1.32605249
69CIITA_25753668_ChIP-Seq_RAJI_Human1.31858280
70POU3F2_20337985_ChIP-ChIP_501MEL_Human1.31413556
71RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.30564182
72GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.30433758
73BP1_19119308_ChIP-ChIP_Hs578T_Human1.27254143
74SCL_19346495_ChIP-Seq_HPC-7_Human1.26577184
75TP63_19390658_ChIP-ChIP_HaCaT_Human1.24876878
76FLI1_27457419_Chip-Seq_LIVER_Mouse1.24229476
77PCGF2_27294783_Chip-Seq_ESCs_Mouse1.23907822
78POU5F1_16153702_ChIP-ChIP_HESCs_Human1.22014137
79MYC_18940864_ChIP-ChIP_HL60_Human1.19186003
80NANOG_16153702_ChIP-ChIP_HESCs_Human1.19037620
81* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.18707512
82LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.17604718
83ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.15911720
84SOX2_16153702_ChIP-ChIP_HESCs_Human1.15475000
85E2F1_21310950_ChIP-Seq_MCF-7_Human1.14541828
86* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.14163752
87CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.12906207
88FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.11181528
89NANOG_18555785_ChIP-Seq_MESCs_Mouse1.10472577
90PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09625007
91ELK1_22589737_ChIP-Seq_MCF10A_Human1.05993734
92MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.05122350
93POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.02630278
94TAF15_26573619_Chip-Seq_HEK293_Human1.01195958
95P300_19829295_ChIP-Seq_ESCs_Human0.99762194
96* HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.98690456
97GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97442154
98MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.94473701
99BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.93928204
100PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.92292338
101ZFP57_27257070_Chip-Seq_ESCs_Mouse0.90418230
102TP53_22573176_ChIP-Seq_HFKS_Human0.89067857
103LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.87484476
104RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.87039392
105FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85572202
106KDM5A_27292631_Chip-Seq_BREAST_Human0.85250256
107IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.85218400
108TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83820549
109MYB_26560356_Chip-Seq_TH1_Human0.83806446
110CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.83577287
111GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.83490192
112EWS_26573619_Chip-Seq_HEK293_Human0.82109137
113FOXM1_23109430_ChIP-Seq_U2OS_Human0.81261744
114SOX17_20123909_ChIP-Seq_XEN_Mouse0.81227969
115EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.80285526
116ZFX_18555785_ChIP-Seq_MESCs_Mouse0.79974079
117* CTBP1_25329375_ChIP-Seq_LNCAP_Human0.79877153
118EZH2_27294783_Chip-Seq_NPCs_Mouse0.79524062
119MYB_26560356_Chip-Seq_TH2_Human0.79331542
120SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.78206039
121CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.77247145
122NFE2_27457419_Chip-Seq_LIVER_Mouse0.76620794
123* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.76614158
124* CTBP2_25329375_ChIP-Seq_LNCAP_Human0.75610073
125CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.75230025
126SOX2_18555785_ChIP-Seq_MESCs_Mouse0.73702650
127STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.73536878
128MYB_21317192_ChIP-Seq_ERMYB_Mouse0.72924513
129KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.72475386

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.41531103
2MP0008058_abnormal_DNA_repair3.37660462
3MP0002396_abnormal_hematopoietic_system3.22646255
4MP0001835_abnormal_antigen_presentation3.18684363
5MP0008057_abnormal_DNA_replication3.04687457
6MP0010094_abnormal_chromosome_stability2.78912593
7MP0005671_abnormal_response_to2.69884613
8MP0003763_abnormal_thymus_physiology2.68645391
9MP0006292_abnormal_olfactory_placode2.64666584
10MP0001986_abnormal_taste_sensitivity2.53441353
11MP0008007_abnormal_cellular_replicative2.45421099
12MP0002132_abnormal_respiratory_system2.44940110
13MP0003111_abnormal_nucleus_morphology2.40630608
14MP0006072_abnormal_retinal_apoptosis2.36304793
15MP0001188_hyperpigmentation2.32887637
16MP0000015_abnormal_ear_pigmentation2.31364739
17MP0009379_abnormal_foot_pigmentation2.27603127
18MP0005075_abnormal_melanosome_morpholog2.26445637
19MP0002148_abnormal_hypersensitivity_rea2.18689473
20MP0009785_altered_susceptibility_to2.14640050
21MP0003077_abnormal_cell_cycle2.10159273
22MP0001293_anophthalmia2.03474657
23MP0003786_premature_aging1.98264374
24MP0000685_abnormal_immune_system1.96665477
25MP0002837_dystrophic_cardiac_calcinosis1.91875621
26MP0001800_abnormal_humoral_immune1.91301574
27MP0009333_abnormal_splenocyte_physiolog1.90547463
28MP0004957_abnormal_blastocyst_morpholog1.90480609
29MP0003567_abnormal_fetal_cardiomyocyte1.88801197
30MP0009697_abnormal_copulation1.82053669
31MP0002398_abnormal_bone_marrow1.80914609
32MP0005000_abnormal_immune_tolerance1.79632674
33MP0002420_abnormal_adaptive_immunity1.75819683
34MP0002452_abnormal_antigen_presenting1.74301337
35MP0005174_abnormal_tail_pigmentation1.74278703
36MP0006035_abnormal_mitochondrial_morpho1.72994682
37MP0001819_abnormal_immune_cell1.72279373
38MP0002723_abnormal_immune_serum1.70109052
39MP0003136_yellow_coat_color1.69169634
40MP0002095_abnormal_skin_pigmentation1.68593514
41MP0000372_irregular_coat_pigmentation1.67367144
42MP0005025_abnormal_response_to1.66386165
43MP0005387_immune_system_phenotype1.60859224
44MP0001790_abnormal_immune_system1.60859224
45MP0003890_abnormal_embryonic-extraembry1.54571795
46MP0003937_abnormal_limbs/digits/tail_de1.54322256
47MP0000689_abnormal_spleen_morphology1.54061248
48MP0000716_abnormal_immune_system1.53032362
49MP0000490_abnormal_crypts_of1.47122866
50MP0002722_abnormal_immune_system1.46936442
51MP0002419_abnormal_innate_immunity1.46225374
52MP0001853_heart_inflammation1.44705474
53MP0005409_darkened_coat_color1.43214507
54MP0005253_abnormal_eye_physiology1.42903791
55MP0008932_abnormal_embryonic_tissue1.42174775
56MP0004381_abnormal_hair_follicle1.42087277
57MP0008789_abnormal_olfactory_epithelium1.39357632
58MP0002429_abnormal_blood_cell1.38268453
59MP0003315_abnormal_perineum_morphology1.37574461
60MP0002163_abnormal_gland_morphology1.35284914
61MP0000631_abnormal_neuroendocrine_gland1.32790162
62MP0003724_increased_susceptibility_to1.31195010
63MP0000703_abnormal_thymus_morphology1.30628582
64MP0004808_abnormal_hematopoietic_stem1.30099526
65MP0002234_abnormal_pharynx_morphology1.28691024
66MP0010030_abnormal_orbit_morphology1.26660981
67MP0002405_respiratory_system_inflammati1.25731076
68MP0008877_abnormal_DNA_methylation1.25301970
69MP0001697_abnormal_embryo_size1.25256506
70MP0001929_abnormal_gametogenesis1.20138127
71MP0003436_decreased_susceptibility_to1.19509988
72MP0001873_stomach_inflammation1.18582407
73MP0005464_abnormal_platelet_physiology1.18349802
74MP0008260_abnormal_autophagy1.18035836
75MP0001984_abnormal_olfaction1.17156138
76MP0002006_tumorigenesis1.16922990
77MP0003186_abnormal_redox_activity1.15081788
78MP0002009_preneoplasia1.15080964
79MP0002233_abnormal_nose_morphology1.14936289
80MP0003806_abnormal_nucleotide_metabolis1.14698150
81MP0001286_abnormal_eye_development1.13742519
82MP0001730_embryonic_growth_arrest1.13084381
83MP0003121_genomic_imprinting1.12931697
84MP0001145_abnormal_male_reproductive1.12569253
85MP0001672_abnormal_embryogenesis/_devel1.11778469
86MP0005380_embryogenesis_phenotype1.11778469
87MP0005171_absent_coat_pigmentation1.11729696
88MP0000653_abnormal_sex_gland1.11412762
89MP0001545_abnormal_hematopoietic_system1.10811175
90MP0005397_hematopoietic_system_phenotyp1.10811175
91MP0002166_altered_tumor_susceptibility1.10528521
92MP0005551_abnormal_eye_electrophysiolog1.09498045
93MP0002084_abnormal_developmental_patter1.09161565
94MP0002751_abnormal_autonomic_nervous1.08857312
95MP0010155_abnormal_intestine_physiology1.08301481
96MP0004147_increased_porphyrin_level1.07323317
97MP0000358_abnormal_cell_content/1.07294567
98MP0000350_abnormal_cell_proliferation1.06785833
99MP0002638_abnormal_pupillary_reflex1.01868686
100MP0002019_abnormal_tumor_incidence1.01757124
101MP0002085_abnormal_embryonic_tissue1.01502820
102MP0003984_embryonic_growth_retardation1.00287838
103MP0002088_abnormal_embryonic_growth/wei0.99198358
104MP0005394_taste/olfaction_phenotype0.98405958
105MP0005499_abnormal_olfactory_system0.98405958
106MP0005391_vision/eye_phenotype0.97727918
107MP0003941_abnormal_skin_development0.96378841
108MP0005408_hypopigmentation0.95319946
109MP0004215_abnormal_myocardial_fiber0.95211580
110MP0000049_abnormal_middle_ear0.94699783
111MP0002697_abnormal_eye_size0.93107261
112MP0000313_abnormal_cell_death0.91680660
113MP0001764_abnormal_homeostasis0.90840058
114MP0001845_abnormal_inflammatory_respons0.89457706
115MP0000858_altered_metastatic_potential0.89270411
116MP0002080_prenatal_lethality0.87606886
117MP0003119_abnormal_digestive_system0.86814700
118MP0000647_abnormal_sebaceous_gland0.85854784
119MP0003880_abnormal_central_pattern0.84918753
120MP0002111_abnormal_tail_morphology0.84408581
121MP0004133_heterotaxia0.83795851
122MP0008995_early_reproductive_senescence0.83773653
123MP0005084_abnormal_gallbladder_morpholo0.83631143
124MP0005645_abnormal_hypothalamus_physiol0.83262152
125MP0002282_abnormal_trachea_morphology0.83189617
126MP0002277_abnormal_respiratory_mucosa0.82869923
127MP0001905_abnormal_dopamine_level0.82692932
128MP0003718_maternal_effect0.82666520
129MP0002876_abnormal_thyroid_physiology0.81880694
130MP0003698_abnormal_male_reproductive0.81364047
131MP0000566_synostosis0.81340658
132MP0000465_gastrointestinal_hemorrhage0.81110170
133MP0001324_abnormal_eye_pigmentation0.80435261
134MP0004197_abnormal_fetal_growth/weight/0.79779599
135MP0002938_white_spotting0.78911262
136MP0002160_abnormal_reproductive_system0.78584290
137MP0002090_abnormal_vision0.78348344
138MP0001119_abnormal_female_reproductive0.78186044
139MP0001661_extended_life_span0.78178828
140MP0003755_abnormal_palate_morphology0.77364360
141MP0001186_pigmentation_phenotype0.76081823
142MP0006036_abnormal_mitochondrial_physio0.75963419
143MP0005310_abnormal_salivary_gland0.75332780
144MP0005389_reproductive_system_phenotype0.74625881
145MP0001919_abnormal_reproductive_system0.73690880
146MP0005646_abnormal_pituitary_gland0.73330824
147MP0003866_abnormal_defecation0.72621269
148MP0005379_endocrine/exocrine_gland_phen0.72605489
149MP0002736_abnormal_nociception_after0.72166832
150MP0004142_abnormal_muscle_tone0.71766902
151MP0002933_joint_inflammation0.69671087
152MP0002102_abnormal_ear_morphology0.69299312
153MP0004782_abnormal_surfactant_physiolog0.68918583
154MP0005195_abnormal_posterior_eye0.67973644
155MP0001529_abnormal_vocalization0.67169885
156MP0002210_abnormal_sex_determination0.66710819
157MP0000613_abnormal_salivary_gland0.65339316
158MP0006276_abnormal_autonomic_nervous0.64448013
159MP0009672_abnormal_birth_weight0.63765485
160MP0008469_abnormal_protein_level0.62599315

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)4.05531046
2Abnormal number of erythroid precursors (HP:0012131)3.98998970
3Reticulocytopenia (HP:0001896)3.66744516
4Acute encephalopathy (HP:0006846)3.58584306
5Type I transferrin isoform profile (HP:0003642)3.53721582
6Chromsome breakage (HP:0040012)3.52667482
7Chromosomal breakage induced by crosslinking agents (HP:0003221)3.36597060
8Progressive macrocephaly (HP:0004481)3.32423576
9Birth length less than 3rd percentile (HP:0003561)3.11935505
10Colon cancer (HP:0003003)3.09857769
11Decreased activity of mitochondrial respiratory chain (HP:0008972)3.07110538
12Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.07110538
13Reduced antithrombin III activity (HP:0001976)3.05602759
14Microvesicular hepatic steatosis (HP:0001414)3.02007238
15Type 2 muscle fiber atrophy (HP:0003554)3.00995522
16Aplastic anemia (HP:0001915)2.98798230
173-Methylglutaconic aciduria (HP:0003535)2.97158651
18Cerebral edema (HP:0002181)2.93689869
19Increased serum pyruvate (HP:0003542)2.91788652
20IgM deficiency (HP:0002850)2.88031501
21Muscle fiber atrophy (HP:0100295)2.82311698
22Abnormality of the labia minora (HP:0012880)2.81231046
23Thrombocytosis (HP:0001894)2.74451185
24Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.71061569
25Hepatocellular necrosis (HP:0001404)2.66320737
26Abnormality of methionine metabolism (HP:0010901)2.62523707
27Abnormality of the prostate (HP:0008775)2.61903596
28Abnormality of glycolysis (HP:0004366)2.57849550
29Abnormal lung lobation (HP:0002101)2.56631609
30Duplicated collecting system (HP:0000081)2.54442178
31Increased hepatocellular lipid droplets (HP:0006565)2.53695555
32IgG deficiency (HP:0004315)2.53079574
33Methylmalonic acidemia (HP:0002912)2.52715814
34Mitochondrial inheritance (HP:0001427)2.52325742
35Abnormality of the preputium (HP:0100587)2.52219720
36Prostate neoplasm (HP:0100787)2.52165870
37Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.50136282
38Pallor (HP:0000980)2.48141513
39Petechiae (HP:0000967)2.47951759
40Abnormality of the renal collecting system (HP:0004742)2.47121360
41Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.40500229
42Abnormal protein N-linked glycosylation (HP:0012347)2.40500229
43Abnormal protein glycosylation (HP:0012346)2.40500229
44Abnormal glycosylation (HP:0012345)2.40500229
45Hypothermia (HP:0002045)2.39753620
46Lactic acidosis (HP:0003128)2.38171365
47Lymphoma (HP:0002665)2.37555141
48Increased serum lactate (HP:0002151)2.35530169
49Panhypogammaglobulinemia (HP:0003139)2.32230183
50Increased CSF lactate (HP:0002490)2.31801525
51Exertional dyspnea (HP:0002875)2.31046472
52Abnormality of the heme biosynthetic pathway (HP:0010472)2.30143702
53Recurrent abscess formation (HP:0002722)2.28039840
54Macrocytic anemia (HP:0001972)2.26556390
55Abnormality of aspartate family amino acid metabolism (HP:0010899)2.26203005
56Abnormality of chromosome stability (HP:0003220)2.25446517
57Triphalangeal thumb (HP:0001199)2.24051987
58Renal Fanconi syndrome (HP:0001994)2.23838430
59Duodenal stenosis (HP:0100867)2.22799044
60Small intestinal stenosis (HP:0012848)2.22799044
61Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.22239494
62Abnormality of alanine metabolism (HP:0010916)2.22239494
63Hyperalaninemia (HP:0003348)2.22239494
64Myelodysplasia (HP:0002863)2.21651838
65Abnormality of serum amino acid levels (HP:0003112)2.21379286
66Abnormality of T cell physiology (HP:0011840)2.21378247
67Asplenia (HP:0001746)2.21372692
68Recurrent cutaneous fungal infections (HP:0011370)2.20776485
69Chronic mucocutaneous candidiasis (HP:0002728)2.20776485
70Hyperglycinemia (HP:0002154)2.20682099
71Hepatic necrosis (HP:0002605)2.20380006
72Bone marrow hypocellularity (HP:0005528)2.19975729
73Acute necrotizing encephalopathy (HP:0006965)2.19175348
74Pancytopenia (HP:0001876)2.18210863
75Clubbing of toes (HP:0100760)2.16911855
76Myositis (HP:0100614)2.16875839
77Meckel diverticulum (HP:0002245)2.16004636
78Medial flaring of the eyebrow (HP:0010747)2.15924442
79True hermaphroditism (HP:0010459)2.15594091
80Agammaglobulinemia (HP:0004432)2.15549171
81Granulocytopenia (HP:0001913)2.15495780
82Nephronophthisis (HP:0000090)2.12785674
83Pancreatic fibrosis (HP:0100732)2.12731916
84Retrobulbar optic neuritis (HP:0100654)2.12418488
85Optic neuritis (HP:0100653)2.12418488
86Abnormality of the columella (HP:0009929)2.12160338
87Septo-optic dysplasia (HP:0100842)2.10971633
88Premature graying of hair (HP:0002216)2.10767235
89Sloping forehead (HP:0000340)2.10763208
90Abnormality of the duodenum (HP:0002246)2.09512159
9111 pairs of ribs (HP:0000878)2.09170805
92Aplasia/Hypoplasia of the uvula (HP:0010293)2.08709203
93Abnormality of the ileum (HP:0001549)2.07724131
94Abnormality of T cells (HP:0002843)2.07511051
95Abnormal delayed hypersensitivity skin test (HP:0002963)2.06162541
96Stenosis of the external auditory canal (HP:0000402)2.05845810
97Methylmalonic aciduria (HP:0012120)2.05692850
98Abnormality of DNA repair (HP:0003254)2.03302169
99Abnormality of midbrain morphology (HP:0002418)2.02067927
100Molar tooth sign on MRI (HP:0002419)2.02067927
101Obstructive lung disease (HP:0006536)2.00710778
102Chronic obstructive pulmonary disease (HP:0006510)2.00710778
103Prolonged bleeding time (HP:0003010)2.00671367
104Patchy hypopigmentation of hair (HP:0011365)1.99682924
105Severe combined immunodeficiency (HP:0004430)1.99323387
106Abnormal mitochondria in muscle tissue (HP:0008316)1.98789795
107Lymphopenia (HP:0001888)1.98269938
108Lipid accumulation in hepatocytes (HP:0006561)1.97826980
109Optic disc pallor (HP:0000543)1.97511217
110Intestinal atresia (HP:0011100)1.97221184
111Encephalitis (HP:0002383)1.96831275
112Aplasia/Hypoplasia of the spleen (HP:0010451)1.96655329
113Abnormal hair whorl (HP:0010721)1.96587424
114Elevated erythrocyte sedimentation rate (HP:0003565)1.95504474
115Hypoplasia of the pons (HP:0012110)1.95249581
116Abnormality of B cell number (HP:0010975)1.94775669
117B lymphocytopenia (HP:0010976)1.94775669
118Volvulus (HP:0002580)1.94767308
119Meningitis (HP:0001287)1.93582492
120Optic nerve coloboma (HP:0000588)1.90911787
121Aplasia/Hypoplasia of the sacrum (HP:0008517)1.90662875
122Respiratory difficulties (HP:0002880)1.90206488
123Neutropenia (HP:0001875)1.90139062
124Absent thumb (HP:0009777)1.88830679
125Abnormality of cells of the lymphoid lineage (HP:0012140)1.88718906
126Recurrent bronchitis (HP:0002837)1.88293490
127Congenital primary aphakia (HP:0007707)1.88018726
128Recurrent bacterial skin infections (HP:0005406)1.87917085
129Abnormality of the pons (HP:0007361)1.87483629
130Horseshoe kidney (HP:0000085)1.86961790
131Lethargy (HP:0001254)1.86115956
132Leukodystrophy (HP:0002415)1.85951796
133Respiratory failure (HP:0002878)1.85386550
134Ectopic kidney (HP:0000086)1.84411426
135Renal cortical cysts (HP:0000803)1.83546710
136Pancreatic cysts (HP:0001737)1.83090608
137Oral leukoplakia (HP:0002745)1.82719980
138Exercise intolerance (HP:0003546)1.80146439
139Short tibia (HP:0005736)1.79430023
140Cerebral hypomyelination (HP:0006808)1.79306653
141Genital tract atresia (HP:0001827)1.79294047
142Recurrent fungal infections (HP:0002841)1.78950066
143Sclerocornea (HP:0000647)1.76417309
144Nephrogenic diabetes insipidus (HP:0009806)1.76027148
145Hypoplastic pelvis (HP:0008839)1.75892229
146Gastrointestinal atresia (HP:0002589)1.74951277
147Aplasia/Hypoplasia of the tongue (HP:0010295)1.73494257
148Neoplasm of the colon (HP:0100273)1.72659413
149Abnormality of homocysteine metabolism (HP:0010919)1.72573561
150Homocystinuria (HP:0002156)1.72573561
151CNS demyelination (HP:0007305)1.71885875
152Anencephaly (HP:0002323)1.71379212
153Vaginal atresia (HP:0000148)1.70737449
154Abnormality of serine family amino acid metabolism (HP:0010894)1.68541512
155Abnormality of glycine metabolism (HP:0010895)1.68541512
156Aplasia/Hypoplasia of the tibia (HP:0005772)1.67656510
157Megaloblastic anemia (HP:0001889)1.67542444
158Preaxial hand polydactyly (HP:0001177)1.67431768

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK163.88832705
2VRK23.22650995
3EIF2AK12.77204127
4TXK2.75250277
5NUAK12.58715960
6EIF2AK32.55832274
7NME22.51932219
8IRAK42.47393907
9SRPK12.45644869
10NEK12.43705443
11TRIM282.31299799
12PIM22.28864303
13TTK2.25062323
14MKNK12.24531180
15MKNK22.23450486
16VRK12.15657753
17BUB12.14471665
18ZAK2.06539595
19TEC1.99338299
20PLK41.91765806
21WNK31.81698933
22MAP4K11.79285433
23TAF11.76523152
24TNIK1.75599745
25CCNB11.70890697
26MAP4K21.66587048
27WEE11.66239163
28MAP3K141.65096400
29IRAK31.64965586
30CDK81.64839389
31ADRBK21.60658525
32TSSK61.56213522
33BLK1.50094043
34PDK21.49733654
35CASK1.49003180
36FRK1.47551404
37BTK1.47317444
38EIF2AK21.45859575
39BCR1.37310704
40KIT1.33250999
41TLK11.31690968
42MUSK1.28808497
43IKBKB1.23136434
44RPS6KA41.22105333
45NLK1.22022654
46SIK31.20433998
47JAK31.20067955
48BMPR1B1.19086289
49BMPR21.14110538
50MST41.13872491
51BCKDK1.12869753
52YES11.11853404
53IKBKE1.07715791
54MAP2K71.05233749
55MAP3K121.03873559
56PASK1.02633462
57PIM11.00475385
58ATR0.95965331
59ZAP700.94806637
60PNCK0.94339727
61PLK20.93892299
62RPS6KB20.93193545
63SYK0.93177298
64CSNK1G10.93141813
65BRSK20.88742795
66PINK10.88629929
67CDK70.87209715
68BRSK10.85123712
69PLK30.85037303
70INSRR0.84548490
71GRK10.83009976
72PLK10.82674839
73TNK20.82528749
74STK38L0.82019093
75LYN0.81201634
76CDC70.80724622
77CSNK1G30.78917345
78ACVR1B0.77376171
79TIE10.75715854
80RPS6KA50.73853608
81AURKB0.73808540
82STK30.73728950
83NEK20.72660408
84STK240.71846246
85WNK40.69863926
86TYK20.69419796
87TGFBR10.68279375
88MAPKAPK50.67813169
89OXSR10.66533088
90NEK60.66460846
91FGFR20.66051542
92LCK0.65683494
93NME10.64981047
94CHEK10.64516380
95MYLK0.63375088
96CLK10.63216817
97ERBB30.62914863
98MAP3K40.62144262
99STK390.61753081
100CSNK1G20.61726263
101AKT30.61677583
102KDR0.61259482
103FLT30.60631236
104STK40.58410845
105CSNK1A1L0.56794917
106CSF1R0.56515398
107CSNK2A10.55658369
108BRAF0.55078158
109CDK30.54653899
110TESK20.54595516
111DYRK30.53740261
112AURKA0.53304948
113LATS10.52270866
114ITK0.50844889
115CHUK0.50645922
116CHEK20.50558281
117STK100.47740457
118IRAK10.47317900
119MAPK130.46936418
120CSNK2A20.46137359
121GRK70.45602699
122DYRK20.45575032
123NEK90.44454109
124FGFR10.40170437
125PBK0.39895821
126PRKCE0.39821808
127ATM0.38986615
128RPS6KA60.38860004
129RPS6KL10.38555616
130RPS6KC10.38555616
131PRPF4B0.38390524
132MAP2K30.36144045
133RPS6KB10.36072448
134CDK10.35948366
135CDK190.35906954
136CSNK1E0.35121329
137CDK20.32238165
138PRKCG0.31041618
139PRKDC0.29864745
140BRD40.28791292
141CSNK1A10.28723705
142OBSCN0.27510575
143ERBB40.23093706

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.97614205
2Proteasome_Homo sapiens_hsa030503.56484919
3RNA polymerase_Homo sapiens_hsa030203.53954878
4DNA replication_Homo sapiens_hsa030303.47816138
5Mismatch repair_Homo sapiens_hsa034303.19971372
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.95768177
7Homologous recombination_Homo sapiens_hsa034402.83203046
8Base excision repair_Homo sapiens_hsa034102.53875879
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.44581000
10Pyrimidine metabolism_Homo sapiens_hsa002402.40782346
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.38696939
12Spliceosome_Homo sapiens_hsa030402.33800728
13Non-homologous end-joining_Homo sapiens_hsa034502.30569420
14Primary immunodeficiency_Homo sapiens_hsa053402.26786542
15Nucleotide excision repair_Homo sapiens_hsa034202.23758733
16Fanconi anemia pathway_Homo sapiens_hsa034602.22505310
17Protein export_Homo sapiens_hsa030602.02694404
18Propanoate metabolism_Homo sapiens_hsa006401.91578993
19Basal transcription factors_Homo sapiens_hsa030221.90357447
20RNA degradation_Homo sapiens_hsa030181.78633453
21RNA transport_Homo sapiens_hsa030131.69185453
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.66856829
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.62772497
24Selenocompound metabolism_Homo sapiens_hsa004501.58675503
25Purine metabolism_Homo sapiens_hsa002301.55969554
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.55391052
27Oxidative phosphorylation_Homo sapiens_hsa001901.55149660
28Allograft rejection_Homo sapiens_hsa053301.48124383
29Cell cycle_Homo sapiens_hsa041101.47779806
30Steroid biosynthesis_Homo sapiens_hsa001001.47105346
31Intestinal immune network for IgA production_Homo sapiens_hsa046721.43322339
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.41694415
33Parkinsons disease_Homo sapiens_hsa050121.40743876
34Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.35654141
35Pyruvate metabolism_Homo sapiens_hsa006201.34888974
36Butanoate metabolism_Homo sapiens_hsa006501.31390024
37One carbon pool by folate_Homo sapiens_hsa006701.29568410
38NF-kappa B signaling pathway_Homo sapiens_hsa040641.26717246
39Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.25968564
40Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.25881521
41Hematopoietic cell lineage_Homo sapiens_hsa046401.24127700
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.19574168
43Huntingtons disease_Homo sapiens_hsa050161.17653372
44Measles_Homo sapiens_hsa051621.17373294
45SNARE interactions in vesicular transport_Homo sapiens_hsa041301.09042802
46Herpes simplex infection_Homo sapiens_hsa051681.08755812
47Autoimmune thyroid disease_Homo sapiens_hsa053201.06589371
48Epstein-Barr virus infection_Homo sapiens_hsa051691.04497515
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.00566616
50Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.99108606
51Antigen processing and presentation_Homo sapiens_hsa046120.98833598
52p53 signaling pathway_Homo sapiens_hsa041150.98230254
53Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.97048233
54RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.96596843
55Graft-versus-host disease_Homo sapiens_hsa053320.93501449
56Carbon metabolism_Homo sapiens_hsa012000.92200307
57Asthma_Homo sapiens_hsa053100.90121096
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.89384912
59Cardiac muscle contraction_Homo sapiens_hsa042600.85428355
60Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.83957531
61Peroxisome_Homo sapiens_hsa041460.81800955
62Biosynthesis of amino acids_Homo sapiens_hsa012300.79832724
63Arachidonic acid metabolism_Homo sapiens_hsa005900.79722304
64Alzheimers disease_Homo sapiens_hsa050100.78553368
65Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.78252472
66Systemic lupus erythematosus_Homo sapiens_hsa053220.76121539
672-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.75769428
68Regulation of autophagy_Homo sapiens_hsa041400.74516537
69Other glycan degradation_Homo sapiens_hsa005110.74298282
70mRNA surveillance pathway_Homo sapiens_hsa030150.73943946
71NOD-like receptor signaling pathway_Homo sapiens_hsa046210.70718044
72Legionellosis_Homo sapiens_hsa051340.70687982
73Oocyte meiosis_Homo sapiens_hsa041140.69865230
74Jak-STAT signaling pathway_Homo sapiens_hsa046300.69573152
75Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.68340391
76Leishmaniasis_Homo sapiens_hsa051400.68309186
77Nitrogen metabolism_Homo sapiens_hsa009100.66958778
78Sphingolipid metabolism_Homo sapiens_hsa006000.63977904
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.63494275
80Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.61961931
81Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59806414
82Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58687047
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57569422
84Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57155484
85Tryptophan metabolism_Homo sapiens_hsa003800.56452572
86Maturity onset diabetes of the young_Homo sapiens_hsa049500.55747733
87Rheumatoid arthritis_Homo sapiens_hsa053230.55511187
88Folate biosynthesis_Homo sapiens_hsa007900.55304923
89Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.53589559
90Fatty acid metabolism_Homo sapiens_hsa012120.52912796
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.52206042
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50640997
93N-Glycan biosynthesis_Homo sapiens_hsa005100.50304800
94Hedgehog signaling pathway_Homo sapiens_hsa043400.49011162
95Influenza A_Homo sapiens_hsa051640.48649900
96Apoptosis_Homo sapiens_hsa042100.47841966
97Type I diabetes mellitus_Homo sapiens_hsa049400.47753301
98Basal cell carcinoma_Homo sapiens_hsa052170.47270877
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46525574
100Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.45917923
101Phototransduction_Homo sapiens_hsa047440.44173042
102Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44123338
103Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.42334111
104Metabolic pathways_Homo sapiens_hsa011000.41716200
105Vitamin B6 metabolism_Homo sapiens_hsa007500.41630752
106beta-Alanine metabolism_Homo sapiens_hsa004100.41592095
107T cell receptor signaling pathway_Homo sapiens_hsa046600.40799275
108Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.40534607
109Fatty acid degradation_Homo sapiens_hsa000710.40472170
110Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.40262439
111HTLV-I infection_Homo sapiens_hsa051660.38084853
112Shigellosis_Homo sapiens_hsa051310.37860751
113Olfactory transduction_Homo sapiens_hsa047400.37569898
114Viral carcinogenesis_Homo sapiens_hsa052030.37303752
115Toll-like receptor signaling pathway_Homo sapiens_hsa046200.37219355
116Pertussis_Homo sapiens_hsa051330.37089499
117Arginine and proline metabolism_Homo sapiens_hsa003300.36980629
118B cell receptor signaling pathway_Homo sapiens_hsa046620.36759783
119Vitamin digestion and absorption_Homo sapiens_hsa049770.36349641
120Chemical carcinogenesis_Homo sapiens_hsa052040.35871550
121Caffeine metabolism_Homo sapiens_hsa002320.35832620
122Primary bile acid biosynthesis_Homo sapiens_hsa001200.35672483
123Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34125929
124Sulfur metabolism_Homo sapiens_hsa009200.34022011
125Malaria_Homo sapiens_hsa051440.33505481
126Sulfur relay system_Homo sapiens_hsa041220.32527276
127Retinol metabolism_Homo sapiens_hsa008300.31316607
128Hepatitis B_Homo sapiens_hsa051610.28092339
129Steroid hormone biosynthesis_Homo sapiens_hsa001400.25272742
130TGF-beta signaling pathway_Homo sapiens_hsa043500.24360027
131Glutathione metabolism_Homo sapiens_hsa004800.24061452
132Ether lipid metabolism_Homo sapiens_hsa005650.23862148
133Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.23578236
134Lysine degradation_Homo sapiens_hsa003100.22526394
135Phagosome_Homo sapiens_hsa041450.22244663
136Linoleic acid metabolism_Homo sapiens_hsa005910.21961971
137Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.21572873
138Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.21572214
139Fatty acid elongation_Homo sapiens_hsa000620.20907194
140Acute myeloid leukemia_Homo sapiens_hsa052210.20864747
141Pentose phosphate pathway_Homo sapiens_hsa000300.20791844
142Tuberculosis_Homo sapiens_hsa051520.20208058
143Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.19297126
144Chemokine signaling pathway_Homo sapiens_hsa040620.17212687
145Wnt signaling pathway_Homo sapiens_hsa043100.16996552
146Alcoholism_Homo sapiens_hsa050340.16122855
147Osteoclast differentiation_Homo sapiens_hsa043800.12887085
148Hippo signaling pathway_Homo sapiens_hsa043900.12456003

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »