DPM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. Human DPM1 lacks a carboxy-terminal transmembrane domain and signal sequence and is regulated by DPM2. Mutations in this gene are associated with congenital disorder of glycosylation type Ie. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.90062155
2respiratory chain complex IV assembly (GO:0008535)5.25143020
3positive regulation of cellular amine metabolic process (GO:0033240)5.02838400
4ribosomal small subunit assembly (GO:0000028)4.70529011
5negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.70384843
6establishment of integrated proviral latency (GO:0075713)4.66983072
7regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.45631382
8CENP-A containing nucleosome assembly (GO:0034080)4.42331765
9positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.38881159
10establishment of protein localization to mitochondrial membrane (GO:0090151)4.38218973
11anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.36081500
12viral transcription (GO:0019083)4.34928302
13SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.34390980
14cotranslational protein targeting to membrane (GO:0006613)4.32129211
15negative regulation of ligase activity (GO:0051352)4.26889459
16negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.26889459
17protein targeting to ER (GO:0045047)4.24342369
18chromatin remodeling at centromere (GO:0031055)4.22943992
19regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033394.19905747
20ribosomal small subunit biogenesis (GO:0042274)4.19441733
21translational termination (GO:0006415)4.17696471
22cytochrome complex assembly (GO:0017004)4.13791909
23protein localization to endoplasmic reticulum (GO:0070972)4.11837465
24negative regulation of metanephros development (GO:0072217)4.05841099
25establishment of protein localization to endoplasmic reticulum (GO:0072599)4.02360147
26proteasome assembly (GO:0043248)3.99760490
27telomere maintenance via semi-conservative replication (GO:0032201)3.99129794
28establishment of viral latency (GO:0019043)3.97168024
29formation of translation preinitiation complex (GO:0001731)3.90878717
30rRNA modification (GO:0000154)3.88975895
31mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.87334756
32mitochondrial respiratory chain complex I assembly (GO:0032981)3.87334756
33NADH dehydrogenase complex assembly (GO:0010257)3.87334756
34lymphoid progenitor cell differentiation (GO:0002320)3.83823920
35positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.77947608
36signal peptide processing (GO:0006465)3.74243373
37platelet dense granule organization (GO:0060155)3.72571587
38DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.72457939
39negative regulation of transcription by competitive promoter binding (GO:0010944)3.71103735
40signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.70907917
41signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.70907917
42signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.70907917
43intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.69346417
44signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.69346417
45nephron tubule formation (GO:0072079)3.67472739
46signal transduction involved in DNA integrity checkpoint (GO:0072401)3.62700132
47signal transduction involved in DNA damage checkpoint (GO:0072422)3.62700132
48mitotic metaphase plate congression (GO:0007080)3.61648637
49positive regulation of ligase activity (GO:0051351)3.61139540
50spliceosomal snRNP assembly (GO:0000387)3.58466964
51histone exchange (GO:0043486)3.58296925
52deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.57614871
53signal transduction involved in cell cycle checkpoint (GO:0072395)3.55640850
54maturation of 5.8S rRNA (GO:0000460)3.50029328
55protein complex biogenesis (GO:0070271)3.49480508
56mesonephros development (GO:0001823)3.48009468
57translational elongation (GO:0006414)3.47745339
58regulation of ubiquitin-protein transferase activity (GO:0051438)3.45881523
59cullin deneddylation (GO:0010388)3.43052307
60DNA replication-independent nucleosome assembly (GO:0006336)3.39807967
61DNA replication-independent nucleosome organization (GO:0034724)3.39807967
62rRNA methylation (GO:0031167)3.39459782
63regulation of mitochondrial translation (GO:0070129)3.37612824
64DNA replication checkpoint (GO:0000076)3.37246880
65ribonucleoprotein complex biogenesis (GO:0022613)3.34411141
66telomere maintenance via recombination (GO:0000722)3.34159659
67regulation of ligase activity (GO:0051340)3.33085226
68purine nucleobase biosynthetic process (GO:0009113)3.33083852
69protein localization to kinetochore (GO:0034501)3.30203538
70pattern specification involved in kidney development (GO:0061004)3.29080155
71DNA ligation (GO:0006266)3.28662362
72regulation of apoptotic process involved in morphogenesis (GO:1902337)3.26975168
73termination of RNA polymerase III transcription (GO:0006386)3.25255579
74transcription elongation from RNA polymerase III promoter (GO:0006385)3.25255579
75metaphase plate congression (GO:0051310)3.24057872
76IMP biosynthetic process (GO:0006188)3.23360069
77regulation of type B pancreatic cell apoptotic process (GO:2000674)3.20324199
78peptidyl-threonine dephosphorylation (GO:0035970)3.18168471
79maturation of SSU-rRNA (GO:0030490)3.17910079
80aerobic respiration (GO:0009060)3.17497384
81rRNA processing (GO:0006364)3.16480502
82histone mRNA metabolic process (GO:0008334)3.16400853
83G1/S transition of mitotic cell cycle (GO:0000082)3.16305243
84cell cycle G1/S phase transition (GO:0044843)3.16305243
85mitotic sister chromatid segregation (GO:0000070)3.16223774
86mitochondrial respiratory chain complex assembly (GO:0033108)3.15069859
87oxidative phosphorylation (GO:0006119)3.14898132
88viral life cycle (GO:0019058)3.14806044
897-methylguanosine mRNA capping (GO:0006370)3.14554873
90mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.14022326
91regulation of cellular amino acid metabolic process (GO:0006521)3.13834659
92transcription from mitochondrial promoter (GO:0006390)3.13760391
93L-fucose catabolic process (GO:0042355)3.12919627
94fucose catabolic process (GO:0019317)3.12919627
95L-fucose metabolic process (GO:0042354)3.12919627
96protein deneddylation (GO:0000338)3.11073110
97negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.09521419
98cellular protein complex disassembly (GO:0043624)3.07983206
99DNA damage response, detection of DNA damage (GO:0042769)3.07276632
100pseudouridine synthesis (GO:0001522)3.06606646
101kinetochore organization (GO:0051383)3.06251673
102RNA capping (GO:0036260)3.05326091
1037-methylguanosine RNA capping (GO:0009452)3.05326091
104translation (GO:0006412)3.04331359
105rRNA metabolic process (GO:0016072)3.02699112
106ribosome biogenesis (GO:0042254)3.01328914
107spindle checkpoint (GO:0031577)3.01321173
108mitotic spindle checkpoint (GO:0071174)3.00986632
109inner mitochondrial membrane organization (GO:0007007)3.00013809
110DNA strand elongation involved in DNA replication (GO:0006271)2.99688992
111negative regulation of mitotic sister chromatid separation (GO:2000816)2.99236583
112negative regulation of sister chromatid segregation (GO:0033046)2.99236583
113negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.99236583
114negative regulation of mitotic sister chromatid segregation (GO:0033048)2.99236583
115translational initiation (GO:0006413)2.95518453
116antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.95345142
117regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.95047227
118ribosomal large subunit biogenesis (GO:0042273)2.93960650
119ribosome assembly (GO:0042255)2.93559035
120DNA strand elongation (GO:0022616)2.90452912
121postsynaptic membrane organization (GO:0001941)2.89561555
122response to interferon-beta (GO:0035456)2.89501533
123GTP biosynthetic process (GO:0006183)2.89500790
124presynaptic membrane assembly (GO:0097105)2.88316338
125DNA replication initiation (GO:0006270)2.88195885
126metallo-sulfur cluster assembly (GO:0031163)2.87375077
127iron-sulfur cluster assembly (GO:0016226)2.87375077
128generation of neurons (GO:0048699)2.86146510
129nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.86031044
130* GPI anchor biosynthetic process (GO:0006506)2.85490637
131urogenital system development (GO:0001655)2.84670140
132regulation of pigment cell differentiation (GO:0050932)2.84192478
133* mannosylation (GO:0097502)2.84074981
134mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.83753721
135mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.82653043
136regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.81726859
137regulation of cellular respiration (GO:0043457)2.81600949
138antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.77866069
139heme biosynthetic process (GO:0006783)2.77506470
140facial nerve structural organization (GO:0021612)2.76325914
141GMP metabolic process (GO:0046037)2.74572709
142positive regulation of glycoprotein biosynthetic process (GO:0010560)2.74379457
143L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.72561961
144pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.71812161
145mitotic recombination (GO:0006312)2.71599830
146energy coupled proton transport, down electrochemical gradient (GO:0015985)2.71071168
147ATP synthesis coupled proton transport (GO:0015986)2.71071168
148* dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.67700456
149positive regulation of protein export from nucleus (GO:0046827)2.67451992
150telomere maintenance via telomere lengthening (GO:0010833)2.67432789
151respiratory electron transport chain (GO:0022904)2.67246825
152protein targeting to membrane (GO:0006612)2.64935622
153guanosine-containing compound biosynthetic process (GO:1901070)2.64375873
154CTP biosynthetic process (GO:0006241)2.63961572
155CTP metabolic process (GO:0046036)2.63961572
156electron transport chain (GO:0022900)2.63452147
157* C-terminal protein lipidation (GO:0006501)2.61183226
158nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.60798079
159exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.59432618
160chaperone-mediated protein transport (GO:0072321)2.58831639
161protein targeting to mitochondrion (GO:0006626)2.58729183
162negative regulation of myotube differentiation (GO:0010832)2.58233796
163cellular component biogenesis (GO:0044085)2.57378604
164mitochondrial DNA replication (GO:0006264)2.55593794

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.11362003
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.92032076
3* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.66545235
4* GABP_17652178_ChIP-ChIP_JURKAT_Human3.52767758
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.42431883
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.38644299
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.27094254
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.21927426
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.16935701
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.95536803
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.89715151
12EZH2_22144423_ChIP-Seq_EOC_Human2.82722128
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.80992647
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.76025118
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.67180088
16SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.66510076
17SRF_21415370_ChIP-Seq_HL-1_Mouse2.55106701
18AR_21909140_ChIP-Seq_LNCAP_Human2.53436942
19FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.50505649
20EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.49626173
21VDR_23849224_ChIP-Seq_CD4+_Human2.38828085
22* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.31139693
23LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.28905131
24ERG_20887958_ChIP-Seq_HPC-7_Mouse2.28061064
25E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.26913084
26GATA1_22025678_ChIP-Seq_K562_Human2.25842702
27* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.21659777
28PADI4_21655091_ChIP-ChIP_MCF-7_Human2.18160769
29IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.17174805
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.16815885
31SCL_19346495_ChIP-Seq_HPC-7_Human2.16782620
32HOXB4_20404135_ChIP-ChIP_EML_Mouse2.07393096
33* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.07290019
34FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.00359114
35NOTCH1_21737748_ChIP-Seq_TLL_Human1.97074386
36MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.93844360
37FOXP3_21729870_ChIP-Seq_TREG_Human1.92626319
38MYCN_18555785_ChIP-Seq_MESCs_Mouse1.84525065
39IRF8_22096565_ChIP-ChIP_GC-B_Human1.81671663
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.81062004
41SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.80262313
42E2F7_22180533_ChIP-Seq_HELA_Human1.79924873
43* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.79784259
44E2F1_21310950_ChIP-Seq_MCF-7_Human1.76676561
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.75072151
46MYC_19030024_ChIP-ChIP_MESCs_Mouse1.73065918
47* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.72989707
48SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.72975140
49ELK1_19687146_ChIP-ChIP_HELA_Human1.68349667
50POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.68014026
51DCP1A_22483619_ChIP-Seq_HELA_Human1.65099912
52SPI1_23547873_ChIP-Seq_NB4_Human1.62602413
53* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.59704289
54HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.56478996
55CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.56385714
56HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.55518080
57MYB_21317192_ChIP-Seq_ERMYB_Mouse1.54982947
58IRF1_19129219_ChIP-ChIP_H3396_Human1.53950277
59PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.53308547
60LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.51023173
61MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.50955625
62MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.44462958
63IGF1R_20145208_ChIP-Seq_DFB_Human1.44203612
64BP1_19119308_ChIP-ChIP_Hs578T_Human1.43900825
65PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.38929399
66POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.37967825
67EGR1_23403033_ChIP-Seq_LIVER_Mouse1.36804349
68* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.36099253
69RBPJ_22232070_ChIP-Seq_NCS_Mouse1.34628301
70NANOG_18555785_ChIP-Seq_MESCs_Mouse1.30112710
71IRF8_21731497_ChIP-ChIP_J774_Mouse1.29965107
72STAT4_19710469_ChIP-ChIP_TH1__Mouse1.26629342
73* GABP_19822575_ChIP-Seq_HepG2_Human1.26472376
74XRN2_22483619_ChIP-Seq_HELA_Human1.20885253
75* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.19136637
76PCGF2_27294783_Chip-Seq_ESCs_Mouse1.17624446
77* TTF2_22483619_ChIP-Seq_HELA_Human1.16402185
78FLI1_27457419_Chip-Seq_LIVER_Mouse1.15937384
79CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.15358688
80SOX17_20123909_ChIP-Seq_XEN_Mouse1.13835084
81* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.13641610
82CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.11576875
83MYC_19079543_ChIP-ChIP_MESCs_Mouse1.11175749
84E2F4_17652178_ChIP-ChIP_JURKAT_Human1.10126026
85* NANOG_16153702_ChIP-ChIP_HESCs_Human1.09208236
86KDM5A_27292631_Chip-Seq_BREAST_Human1.07756666
87* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.07394314
88GATA1_22383799_ChIP-Seq_G1ME_Mouse1.07111619
89MYC_18940864_ChIP-ChIP_HL60_Human1.06128284
90GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05263860
91EWS_26573619_Chip-Seq_HEK293_Human1.03209062
92TFEB_21752829_ChIP-Seq_HELA_Human1.02801022
93PU.1_20513432_ChIP-Seq_Bcells_Mouse1.02012185
94TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01252457
95GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.00928031
96TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.00814562
97E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00639612
98MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.00099808
99PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00093079
100ELK1_22589737_ChIP-Seq_MCF10A_Human0.99910358
101* NELFA_20434984_ChIP-Seq_ESCs_Mouse0.99710506
102MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.99157302
103ELF5_23300383_ChIP-Seq_T47D_Human0.97055870
104IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.95631263
105SALL1_21062744_ChIP-ChIP_HESCs_Human0.95306216
106PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.95252583
107* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.94792067
108FUS_26573619_Chip-Seq_HEK293_Human0.93842106
109ERG_20517297_ChIP-Seq_VCAP_Human0.90516971
110GATA3_21867929_ChIP-Seq_CD8_Mouse0.89961471
111STAT1_20625510_ChIP-Seq_HELA_Human0.89229311
112FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88034318
113CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.87122278
114ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.85403112
115CIITA_25753668_ChIP-Seq_RAJI_Human0.85060639
116SOX2_16153702_ChIP-ChIP_HESCs_Human0.84915200
117POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.82791298
118CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81802502
119PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81285657
120CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.80931066
121KAP1_22055183_ChIP-Seq_ESCs_Mouse0.80714686
122ZFX_18555785_ChIP-Seq_MESCs_Mouse0.80468229
123LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.80437970
124GATA2_22383799_ChIP-Seq_G1ME_Mouse0.79034739
125SOX2_18555785_ChIP-Seq_MESCs_Mouse0.78543634
126NFE2_27457419_Chip-Seq_LIVER_Mouse0.78018108
127ESR1_15608294_ChIP-ChIP_MCF-7_Human0.77843988
128DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.76834943
129POU5F1_16153702_ChIP-ChIP_HESCs_Human0.76483689
130VDR_24763502_ChIP-Seq_THP-1_Human0.76265635
131KLF4_18555785_ChIP-Seq_MESCs_Mouse0.76082827
132YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.75841652
133NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.75719371
134BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.75631907
135HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.74397550
136SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.74385353
137EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.74353199
138ZNF263_19887448_ChIP-Seq_K562_Human0.74040171
139CTCF_18555785_ChIP-Seq_MESCs_Mouse0.73552746
140STAT3_1855785_ChIP-Seq_MESCs_Mouse0.71147963
141NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.71109304
142ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.70168303
143DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.69649514
144* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.69540451

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.96226945
2MP0004957_abnormal_blastocyst_morpholog4.60545645
3MP0005409_darkened_coat_color3.56560133
4MP0001188_hyperpigmentation3.54672043
5MP0003077_abnormal_cell_cycle3.45850268
6MP0003111_abnormal_nucleus_morphology3.33682036
7MP0005174_abnormal_tail_pigmentation3.22541631
8MP0005075_abnormal_melanosome_morpholog3.01078264
9MP0008932_abnormal_embryonic_tissue2.89022945
10MP0006292_abnormal_olfactory_placode2.87204365
11MP0003941_abnormal_skin_development2.76310942
12MP0003724_increased_susceptibility_to2.66809189
13MP0000015_abnormal_ear_pigmentation2.47180645
14MP0003646_muscle_fatigue2.40396243
15MP0001986_abnormal_taste_sensitivity2.32471350
16MP0002396_abnormal_hematopoietic_system2.26807862
17MP0009785_altered_susceptibility_to2.23747057
18MP0001835_abnormal_antigen_presentation2.20760729
19MP0002876_abnormal_thyroid_physiology2.16553852
20MP0004381_abnormal_hair_follicle2.14225343
21MP0004147_increased_porphyrin_level2.13743955
22MP0003879_abnormal_hair_cell2.11129161
23MP0003136_yellow_coat_color2.08549368
24MP0005671_abnormal_response_to2.02217185
25MP0000681_abnormal_thyroid_gland1.96398234
26MP0002148_abnormal_hypersensitivity_rea1.96115673
27MP0008260_abnormal_autophagy1.95492730
28MP0003806_abnormal_nucleotide_metabolis1.94974650
29MP0005408_hypopigmentation1.93687776
30MP0002095_abnormal_skin_pigmentation1.93086074
31MP0000372_irregular_coat_pigmentation1.91264607
32MP0000490_abnormal_crypts_of1.79558159
33MP0003868_abnormal_feces_composition1.72909372
34MP0003880_abnormal_central_pattern1.71793213
35MP0002638_abnormal_pupillary_reflex1.68931970
36MP0005025_abnormal_response_to1.68737839
37MP0001293_anophthalmia1.67969970
38MP0001730_embryonic_growth_arrest1.66410561
39MP0003890_abnormal_embryonic-extraembry1.66261960
40MP0000350_abnormal_cell_proliferation1.60878031
41MP0001853_heart_inflammation1.60838580
42MP0010030_abnormal_orbit_morphology1.59308290
43MP0006036_abnormal_mitochondrial_physio1.58747553
44MP0001697_abnormal_embryo_size1.57431080
45MP0000465_gastrointestinal_hemorrhage1.55286098
46MP0003315_abnormal_perineum_morphology1.50509216
47MP0000685_abnormal_immune_system1.45576374
48MP0003763_abnormal_thymus_physiology1.44903224
49MP0005000_abnormal_immune_tolerance1.42808317
50MP0008058_abnormal_DNA_repair1.42431003
51MP0002419_abnormal_innate_immunity1.41630096
52MP0001672_abnormal_embryogenesis/_devel1.34124888
53MP0005380_embryogenesis_phenotype1.34124888
54MP0003567_abnormal_fetal_cardiomyocyte1.32620512
55MP0002723_abnormal_immune_serum1.31882771
56MP0009333_abnormal_splenocyte_physiolog1.30859406
57MP0000358_abnormal_cell_content/1.28460763
58MP0004142_abnormal_muscle_tone1.28293295
59MP0001529_abnormal_vocalization1.28247051
60MP0009697_abnormal_copulation1.26505193
61MP0002420_abnormal_adaptive_immunity1.26424466
62MP0001905_abnormal_dopamine_level1.25617759
63MP0001929_abnormal_gametogenesis1.25058046
64MP0003436_decreased_susceptibility_to1.24138204
65MP0001819_abnormal_immune_cell1.23820846
66MP0003693_abnormal_embryo_hatching1.22935500
67MP0001764_abnormal_homeostasis1.22837651
68MP0003186_abnormal_redox_activity1.21875889
69MP0002080_prenatal_lethality1.20524321
70MP0003221_abnormal_cardiomyocyte_apopto1.17685983
71MP0004233_abnormal_muscle_weight1.17622324
72MP0001800_abnormal_humoral_immune1.16866768
73MP0002132_abnormal_respiratory_system1.15533267
74MP0005379_endocrine/exocrine_gland_phen1.14963952
75MP0003937_abnormal_limbs/digits/tail_de1.14726626
76MP0002085_abnormal_embryonic_tissue1.12568648
77MP0008875_abnormal_xenobiotic_pharmacok1.11333104
78MP0003984_embryonic_growth_retardation1.10839396
79MP0002452_abnormal_antigen_presenting1.10476223
80MP0002282_abnormal_trachea_morphology1.10406162
81MP0005464_abnormal_platelet_physiology1.10299070
82MP0001286_abnormal_eye_development1.10237838
83MP0000716_abnormal_immune_system1.09574585
84MP0002398_abnormal_bone_marrow1.09439869
85MP0002088_abnormal_embryonic_growth/wei1.07873159
86MP0000313_abnormal_cell_death1.07737811
87MP0003123_paternal_imprinting1.07249351
88MP0002084_abnormal_developmental_patter1.07012659
89MP0000689_abnormal_spleen_morphology1.06559935
90MP0003866_abnormal_defecation1.05623800
91MP0006072_abnormal_retinal_apoptosis1.02747254
92MP0008995_early_reproductive_senescence1.02013556
93MP0008057_abnormal_DNA_replication1.01977548
94MP0001145_abnormal_male_reproductive1.01608390
95MP0002090_abnormal_vision1.01508823
96MP0000647_abnormal_sebaceous_gland1.01327898
97MP0003195_calcinosis1.01207139
98MP0002938_white_spotting0.98636250
99MP0002160_abnormal_reproductive_system0.97944393
100MP0001873_stomach_inflammation0.96503020
101MP0008469_abnormal_protein_level0.96135205
102MP0000653_abnormal_sex_gland0.96128265
103MP0000613_abnormal_salivary_gland0.96117264
104MP0000631_abnormal_neuroendocrine_gland0.95862805
105MP0010155_abnormal_intestine_physiology0.95734414
106MP0001727_abnormal_embryo_implantation0.95152802
107MP0003786_premature_aging0.94002977
108MP0002429_abnormal_blood_cell0.93792928
109MP0001790_abnormal_immune_system0.93729556
110MP0005387_immune_system_phenotype0.93729556
111MP0002722_abnormal_immune_system0.93470540
112MP0002697_abnormal_eye_size0.89098469
113MP0008789_abnormal_olfactory_epithelium0.88235962
114MP0001346_abnormal_lacrimal_gland0.88071075
115MP0001845_abnormal_inflammatory_respons0.87016163
116MP0005397_hematopoietic_system_phenotyp0.86762842
117MP0001545_abnormal_hematopoietic_system0.86762842
118MP0003950_abnormal_plasma_membrane0.86451346
119MP0009672_abnormal_birth_weight0.85610192
120MP0002102_abnormal_ear_morphology0.85560411
121MP0002177_abnormal_outer_ear0.85419216
122MP0002086_abnormal_extraembryonic_tissu0.83743085
123MP0001666_abnormal_nutrient_absorption0.83464174
124MP0005636_abnormal_mineral_homeostasis0.83034306
125MP0003938_abnormal_ear_development0.82869514
126MP0000762_abnormal_tongue_morphology0.80109035
127MP0010307_abnormal_tumor_latency0.80043782
128MP0008877_abnormal_DNA_methylation0.79431059
129MP0003656_abnormal_erythrocyte_physiolo0.79071700
130MP0009764_decreased_sensitivity_to0.78866909
131MP0008007_abnormal_cellular_replicative0.78675933
132MP0006035_abnormal_mitochondrial_morpho0.78516538
133MP0002233_abnormal_nose_morphology0.77565589
134MP0004264_abnormal_extraembryonic_tissu0.76403835
135MP0002166_altered_tumor_susceptibility0.75857888
136MP0002796_impaired_skin_barrier0.74929655
137MP0001502_abnormal_circadian_rhythm0.74776276
138MP0001881_abnormal_mammary_gland0.74701814
139MP0005330_cardiomyopathy0.73589259
140MP0000049_abnormal_middle_ear0.73068501
141MP0002019_abnormal_tumor_incidence0.72967241
142MP0003121_genomic_imprinting0.72828368
143MP0002272_abnormal_nervous_system0.71808192
144MP0002111_abnormal_tail_morphology0.71572902
145MP0001119_abnormal_female_reproductive0.71368764
146MP0005501_abnormal_skin_physiology0.71250544
147MP0005395_other_phenotype0.71104943
148MP0005085_abnormal_gallbladder_physiolo0.70967495
149MP0000749_muscle_degeneration0.70256867
150MP0006276_abnormal_autonomic_nervous0.69622892
151MP0000678_abnormal_parathyroid_gland0.69333180
152MP0000627_abnormal_mammary_gland0.69303384
153MP0005266_abnormal_metabolism0.69186448
154MP0001663_abnormal_digestive_system0.69071961
155MP0005389_reproductive_system_phenotype0.68924075
156MP0005084_abnormal_gallbladder_morpholo0.67956462
157MP0005332_abnormal_amino_acid0.67848264
158MP0004197_abnormal_fetal_growth/weight/0.67720110
159MP0002693_abnormal_pancreas_physiology0.67651364
160MP0010094_abnormal_chromosome_stability0.67182985
161MP0003698_abnormal_male_reproductive0.66497179
162MP0003011_delayed_dark_adaptation0.66409057
163MP0002098_abnormal_vibrissa_morphology0.64748331
164MP0005584_abnormal_enzyme/coenzyme_acti0.64160105
165MP0002405_respiratory_system_inflammati0.63947671
166MP0002006_tumorigenesis0.63719736
167MP0002234_abnormal_pharynx_morphology0.63573598
168MP0002210_abnormal_sex_determination0.63572955
169MP0005410_abnormal_fertilization0.63317633
170MP0002092_abnormal_eye_morphology0.63038023
171MP0003755_abnormal_palate_morphology0.62478989
172MP0005391_vision/eye_phenotype0.60651227
173MP0003718_maternal_effect0.60624022
174MP0000920_abnormal_myelination0.60222760

Predicted human phenotypes

RankGene SetZ-score
1Hypothermia (HP:0002045)5.60449342
2Thyroid-stimulating hormone excess (HP:0002925)5.18520140
3* Type I transferrin isoform profile (HP:0003642)5.00266991
4Abnormal number of erythroid precursors (HP:0012131)4.61701587
5Abnormality of cells of the erythroid lineage (HP:0012130)4.50389244
6Increased hepatocellular lipid droplets (HP:0006565)4.32047957
7Hepatocellular necrosis (HP:0001404)4.30041887
8Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.19314025
9* Reduced antithrombin III activity (HP:0001976)4.16172649
10Renal Fanconi syndrome (HP:0001994)4.08327856
11Hepatic necrosis (HP:0002605)3.97797392
12Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.96378778
13Increased serum pyruvate (HP:0003542)3.93921408
14Lipid accumulation in hepatocytes (HP:0006561)3.91286314
153-Methylglutaconic aciduria (HP:0003535)3.64261383
16Exertional dyspnea (HP:0002875)3.64030927
17* Abnormal protein glycosylation (HP:0012346)3.61277236
18* Abnormal glycosylation (HP:0012345)3.61277236
19* Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.61277236
20* Abnormal protein N-linked glycosylation (HP:0012347)3.61277236
21Abnormality of glycolysis (HP:0004366)3.59249102
22Mitochondrial inheritance (HP:0001427)3.59204890
23Absent rod-and cone-mediated responses on ERG (HP:0007688)3.47851763
24Abnormality of methionine metabolism (HP:0010901)3.40995751
25Increased intramyocellular lipid droplets (HP:0012240)3.40215559
26Increased CSF lactate (HP:0002490)3.18051428
27Acute necrotizing encephalopathy (HP:0006965)3.17090444
28Severe visual impairment (HP:0001141)3.16884641
29Degeneration of anterior horn cells (HP:0002398)3.12414601
30Abnormality of the anterior horn cell (HP:0006802)3.12414601
31Increased muscle lipid content (HP:0009058)2.97315088
32Reticulocytopenia (HP:0001896)2.96155997
33Abnormal mitochondria in muscle tissue (HP:0008316)2.92690628
34Decreased activity of mitochondrial respiratory chain (HP:0008972)2.91766103
35Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.91766103
36Chromosomal breakage induced by crosslinking agents (HP:0003221)2.89860298
37Meckel diverticulum (HP:0002245)2.89832749
38Microvesicular hepatic steatosis (HP:0001414)2.85489612
39Respiratory difficulties (HP:0002880)2.76906026
40Abnormality of the preputium (HP:0100587)2.76213299
41Increased serum lactate (HP:0002151)2.75967763
42Abnormality of the ileum (HP:0001549)2.75811028
43Abnormality of renal resorption (HP:0011038)2.72879891
44Abnormality of the heme biosynthetic pathway (HP:0010472)2.71512508
45Type 2 muscle fiber atrophy (HP:0003554)2.71179179
46Elevated erythrocyte sedimentation rate (HP:0003565)2.71151014
47Macrocytic anemia (HP:0001972)2.68132225
48Chromsome breakage (HP:0040012)2.66735427
49Abnormality of placental membranes (HP:0011409)2.65520297
50Amniotic constriction ring (HP:0009775)2.65520297
51Petechiae (HP:0000967)2.64860264
52Abnormality of serum amino acid levels (HP:0003112)2.64453420
53Acute encephalopathy (HP:0006846)2.63507444
54Abnormality of the axillary hair (HP:0100134)2.61044783
55Abnormality of secondary sexual hair (HP:0009888)2.61044783
56Abnormality of chromosome stability (HP:0003220)2.55718511
57Abnormality of aspartate family amino acid metabolism (HP:0010899)2.53605321
58Abnormal rod and cone electroretinograms (HP:0008323)2.50442835
59Muscle fiber atrophy (HP:0100295)2.49520110
60Thrombocytosis (HP:0001894)2.48581558
61Aplasia/Hypoplasia of the uvula (HP:0010293)2.48211498
62Exercise intolerance (HP:0003546)2.44889297
63IgM deficiency (HP:0002850)2.44872294
64Lactic acidosis (HP:0003128)2.42572617
65Aplastic anemia (HP:0001915)2.40671362
66Leukodystrophy (HP:0002415)2.39221518
67Pallor (HP:0000980)2.37029952
68Progressive macrocephaly (HP:0004481)2.35422744
69Abnormal lung lobation (HP:0002101)2.34778136
70Megaloblastic anemia (HP:0001889)2.34502161
71Multiple enchondromatosis (HP:0005701)2.32034602
72Nonprogressive disorder (HP:0003680)2.27934857
73Abnormality of magnesium homeostasis (HP:0004921)2.27435136
74Methylmalonic acidemia (HP:0002912)2.25942141
75Oral leukoplakia (HP:0002745)2.23451520
76Sparse eyelashes (HP:0000653)2.23226034
77Small intestinal stenosis (HP:0012848)2.20225006
78Duodenal stenosis (HP:0100867)2.20225006
79Attenuation of retinal blood vessels (HP:0007843)2.19168449
80Stenosis of the external auditory canal (HP:0000402)2.18904936
81True hermaphroditism (HP:0010459)2.16350542
82Hyperglycinemia (HP:0002154)2.16101534
83Abnormality of the prostate (HP:0008775)2.15493515
84Chronic otitis media (HP:0000389)2.14213152
85Congenital, generalized hypertrichosis (HP:0004540)2.13129283
86Microcytic anemia (HP:0001935)2.10380612
87Median cleft lip (HP:0000161)2.09349186
88Myositis (HP:0100614)2.09195693
89Optic disc pallor (HP:0000543)2.08933643
90Abnormality of alanine metabolism (HP:0010916)2.07200138
91Hyperalaninemia (HP:0003348)2.07200138
92Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.07200138
93Pancytopenia (HP:0001876)2.04176089
94Generalized aminoaciduria (HP:0002909)2.03807380
95Abnormal spermatogenesis (HP:0008669)2.01187085
96Glycosuria (HP:0003076)2.01023529
97Abnormality of urine glucose concentration (HP:0011016)2.01023529
98Pancreatic fibrosis (HP:0100732)1.99416793
99Birth length less than 3rd percentile (HP:0003561)1.99241651
100Abnormalities of placenta or umbilical cord (HP:0001194)1.98134287
101Split foot (HP:0001839)1.97587011
102Cerebral edema (HP:0002181)1.96683676
103Bifid tongue (HP:0010297)1.93629930
104Abnormality of the duodenum (HP:0002246)1.92268826
105Azoospermia (HP:0000027)1.91600210
106Nephroblastoma (Wilms tumor) (HP:0002667)1.91500738
107Triphalangeal thumb (HP:0001199)1.91343581
108Respiratory failure (HP:0002878)1.91248613
109Myelodysplasia (HP:0002863)1.91189770
110Palpitations (HP:0001962)1.87006364
111Recurrent abscess formation (HP:0002722)1.86972541
112CNS demyelination (HP:0007305)1.86554610
113Vacuolated lymphocytes (HP:0001922)1.85996359
114Embryonal renal neoplasm (HP:0011794)1.82977966
115Hypoglycemic coma (HP:0001325)1.81421500
116Methylmalonic aciduria (HP:0012120)1.81025278
117Rough bone trabeculation (HP:0100670)1.80460996
118Facial cleft (HP:0002006)1.79862481
119Renal tubular dysfunction (HP:0000124)1.79767437
120Hyperbilirubinemia (HP:0002904)1.79408497
121Thoracic kyphosis (HP:0002942)1.78296615
122Abnormality of dicarboxylic acid metabolism (HP:0010995)1.77589115
123Dicarboxylic aciduria (HP:0003215)1.77589115
124Patchy hypopigmentation of hair (HP:0011365)1.76888600
125Meningitis (HP:0001287)1.76870799
126Neutropenia (HP:0001875)1.76807315
127Short tibia (HP:0005736)1.76742312
128Aplasia/Hypoplasia of the sacrum (HP:0008517)1.74987447
129Hypoplasia of the pons (HP:0012110)1.74463688
130Stomatitis (HP:0010280)1.74394664
131Abnormality of sulfur amino acid metabolism (HP:0004339)1.73838053
132Hyperphosphaturia (HP:0003109)1.73570920
133Panhypogammaglobulinemia (HP:0003139)1.72369852
134Sloping forehead (HP:0000340)1.72157089
135B lymphocytopenia (HP:0010976)1.71966966
136Abnormality of B cell number (HP:0010975)1.71966966
137Abnormality of the pons (HP:0007361)1.71765517
138X-linked dominant inheritance (HP:0001423)1.71159890
139Obstructive lung disease (HP:0006536)1.70964663
140Chronic obstructive pulmonary disease (HP:0006510)1.70964663
141Horseshoe kidney (HP:0000085)1.70576413
142Pancreatic cysts (HP:0001737)1.70427406
143Prolonged bleeding time (HP:0003010)1.70183233
144Absent thumb (HP:0009777)1.69911234
145Recurrent bacterial skin infections (HP:0005406)1.67361988
146Progressive muscle weakness (HP:0003323)1.66231108
147Aplasia/hypoplasia of the uterus (HP:0008684)1.65740424
148Abnormality of the columella (HP:0009929)1.65559495
149Lethargy (HP:0001254)1.63683690
150Epistaxis (HP:0000421)1.61642718
151Abnormality of T cell physiology (HP:0011840)1.58917729

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK9.25634748
2EIF2AK34.81492465
3PBK4.03693357
4VRK23.70214727
5STK163.68814576
6NLK3.28460071
7NEK12.90165583
8CAMKK22.64966417
9CDC72.58902722
10TTK2.56714940
11TSSK62.53338606
12MUSK2.50175488
13TAF12.21404831
14TRIM282.18051941
15PLK32.03840055
16KIT2.03319722
17WEE11.99037916
18NME21.97713478
19TEC1.90350530
20IRAK31.89269376
21MKNK21.88349650
22IRAK41.82744286
23VRK11.68388466
24EIF2AK21.68287346
25CDK191.66027462
26FES1.62496338
27PIM21.62317425
28SCYL21.47980154
29PDK21.43712552
30PLK11.40862523
31CASK1.40621803
32MKNK11.40500730
33BUB11.26502306
34NUAK11.24728998
35FLT31.22236109
36MAP2K71.20952751
37BCR1.19103212
38AURKB1.18017556
39MAP3K121.14477592
40ERBB31.11718220
41TLK11.11411212
42RPS6KA41.10814673
43BRSK11.04027127
44PNCK1.03559667
45ACVR1B1.02987819
46CAMK11.01841446
47PAK41.00837277
48CHEK20.99930502
49STK38L0.97342374
50YES10.96965801
51BTK0.96187729
52MAP4K20.95940819
53PASK0.94085964
54ADRBK20.93479501
55BCKDK0.90655678
56TXK0.89003525
57BLK0.88736073
58CSF1R0.86770591
59BRSK20.86675399
60EPHA20.85779243
61SRPK10.85176801
62RIPK40.82800656
63MAPKAPK50.81483698
64ATR0.81077918
65DYRK30.80289597
66EIF2AK10.80248462
67TIE10.79172094
68NEK20.78612268
69ERBB40.74472446
70TESK20.74327699
71AURKA0.73362453
72MST1R0.72078548
73WNK30.71104430
74IRAK20.68952602
75MST40.68603001
76PLK20.68320451
77SYK0.67897034
78CLK10.67024186
79LYN0.65145306
80TESK10.65144043
81IRAK10.63761068
82PINK10.63145222
83LATS20.62438571
84MAPK40.60733214
85GRK70.60490516
86MAP4K10.59122636
87LIMK10.58909439
88TAOK30.58698031
89STK30.58522307
90CHEK10.58111153
91FGFR10.57257903
92IKBKE0.56301703
93ZAK0.54778414
94STK40.54505807
95PRPF4B0.54294404
96MATK0.54136078
97MYLK0.53709166
98CCNB10.53038608
99BMPR1B0.52749135
100CDK60.52578149
101NME10.52297781
102STK390.52090209
103KDR0.52067879
104MAPK150.50751724
105TYK20.50653765
106PLK40.49394719
107ZAP700.48989803
108ARAF0.48121772
109CSNK1G30.47559379
110IKBKB0.47109551
111ATM0.46597550
112CDK80.46194060
113STK240.44756989
114LATS10.42764258
115MAPKAPK30.42368438
116CDK70.42196477
117CDK30.42147569
118OXSR10.42034706
119CSNK1G10.40599070
120LCK0.40271103
121MAP3K80.40196251
122MAPK130.39359006
123DAPK10.38377843
124STK100.37740760
125CDK90.37007825
126PIK3CG0.35297534
127TBK10.35130690
128CSNK1E0.34814770
129TGFBR20.34813581
130ABL20.34777863
131BMPR20.34641840
132ILK0.34332347
133CSNK2A10.33063332
134CSNK2A20.32852275
135GRK10.32568121
136DYRK20.32182886
137MAP3K60.32149977
138ALK0.31419940
139RAF10.31109125
140NEK60.30707137
141TNK20.30696820
142CDK10.30458420
143INSRR0.29559795
144CAMKK10.27964829
145CDK40.27944422
146MET0.27191410
147PRKG20.27034415
148RPS6KA50.26645996
149PIM10.25548327
150RPS6KB20.24140392
151TAOK20.23209346
152TGFBR10.22625784
153MAP2K60.22153170
154MAP3K140.22135922
155MAP2K30.20851254
156CDK20.20638053
157CSNK1G20.20527717
158CSNK1A1L0.19637336

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.64356137
2Protein export_Homo sapiens_hsa030604.19750089
3DNA replication_Homo sapiens_hsa030303.82546112
4Proteasome_Homo sapiens_hsa030502.91507496
5Oxidative phosphorylation_Homo sapiens_hsa001902.82629957
6RNA polymerase_Homo sapiens_hsa030202.80893763
7Pyrimidine metabolism_Homo sapiens_hsa002402.39531135
8Homologous recombination_Homo sapiens_hsa034402.39220456
9Mismatch repair_Homo sapiens_hsa034302.38069659
10Parkinsons disease_Homo sapiens_hsa050122.18147792
11Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.14018038
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.05508415
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.86680410
14Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.86104601
15Base excision repair_Homo sapiens_hsa034101.85075039
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.80459625
17Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.80310960
18Nucleotide excision repair_Homo sapiens_hsa034201.78908478
19Thyroid cancer_Homo sapiens_hsa052161.59768159
20Other glycan degradation_Homo sapiens_hsa005111.59524480
21Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.59276497
22Spliceosome_Homo sapiens_hsa030401.57586123
23Folate biosynthesis_Homo sapiens_hsa007901.56081116
24Alzheimers disease_Homo sapiens_hsa050101.55275267
25Huntingtons disease_Homo sapiens_hsa050161.54594150
26Sulfur relay system_Homo sapiens_hsa041221.53391010
27Purine metabolism_Homo sapiens_hsa002301.51024062
28Fatty acid elongation_Homo sapiens_hsa000621.49782939
29Basal transcription factors_Homo sapiens_hsa030221.46375434
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.45390162
31Pyruvate metabolism_Homo sapiens_hsa006201.43202054
32Propanoate metabolism_Homo sapiens_hsa006401.41225073
33Fanconi anemia pathway_Homo sapiens_hsa034601.38409530
34Steroid biosynthesis_Homo sapiens_hsa001001.37232969
35Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.37154101
36Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.31329599
37Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.31146308
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.29758571
39Primary immunodeficiency_Homo sapiens_hsa053401.28049093
40Non-homologous end-joining_Homo sapiens_hsa034501.22944443
41* N-Glycan biosynthesis_Homo sapiens_hsa005101.19605442
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.13443417
43Biosynthesis of amino acids_Homo sapiens_hsa012301.04792997
44Carbon metabolism_Homo sapiens_hsa012001.04574895
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.04385075
46Regulation of autophagy_Homo sapiens_hsa041400.99703413
47mRNA surveillance pathway_Homo sapiens_hsa030150.99365293
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.94763062
49Pentose phosphate pathway_Homo sapiens_hsa000300.90515016
50Sphingolipid metabolism_Homo sapiens_hsa006000.89688803
51Drug metabolism - other enzymes_Homo sapiens_hsa009830.88914977
52RNA degradation_Homo sapiens_hsa030180.88824484
53RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.87094980
54SNARE interactions in vesicular transport_Homo sapiens_hsa041300.86819993
55Arachidonic acid metabolism_Homo sapiens_hsa005900.86613642
56Steroid hormone biosynthesis_Homo sapiens_hsa001400.85424423
57* Metabolic pathways_Homo sapiens_hsa011000.84892092
58Hematopoietic cell lineage_Homo sapiens_hsa046400.84071200
59Maturity onset diabetes of the young_Homo sapiens_hsa049500.83588217
60Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.82310089
61Selenocompound metabolism_Homo sapiens_hsa004500.81505162
62Pentose and glucuronate interconversions_Homo sapiens_hsa000400.80271995
63Glutathione metabolism_Homo sapiens_hsa004800.80152876
64Cardiac muscle contraction_Homo sapiens_hsa042600.79798412
65Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.79535246
66Sulfur metabolism_Homo sapiens_hsa009200.78737962
67Peroxisome_Homo sapiens_hsa041460.75214446
68Histidine metabolism_Homo sapiens_hsa003400.70625803
69Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.70499747
70Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.70004273
71Intestinal immune network for IgA production_Homo sapiens_hsa046720.69618697
72Oocyte meiosis_Homo sapiens_hsa041140.67389036
73Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64782582
74Systemic lupus erythematosus_Homo sapiens_hsa053220.64556027
75Allograft rejection_Homo sapiens_hsa053300.64296904
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.60834566
77One carbon pool by folate_Homo sapiens_hsa006700.59322043
78Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.58247056
79Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57013048
80Herpes simplex infection_Homo sapiens_hsa051680.56577102
81Asthma_Homo sapiens_hsa053100.55167382
82Phototransduction_Homo sapiens_hsa047440.54913100
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.52984571
84Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52820890
85Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51924791
86ABC transporters_Homo sapiens_hsa020100.51599276
87Epstein-Barr virus infection_Homo sapiens_hsa051690.50941261
88Butanoate metabolism_Homo sapiens_hsa006500.50918365
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50662264
90Measles_Homo sapiens_hsa051620.50643266
91Linoleic acid metabolism_Homo sapiens_hsa005910.50371022
92Fatty acid metabolism_Homo sapiens_hsa012120.49066366
93Caffeine metabolism_Homo sapiens_hsa002320.47015687
94Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.46646953
95Vitamin digestion and absorption_Homo sapiens_hsa049770.46608944
96Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46501072
97Ether lipid metabolism_Homo sapiens_hsa005650.46204993
98Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.46180868
99Retinol metabolism_Homo sapiens_hsa008300.46071906
100Rheumatoid arthritis_Homo sapiens_hsa053230.45842855
101Malaria_Homo sapiens_hsa051440.45656892
102NF-kappa B signaling pathway_Homo sapiens_hsa040640.43678685
103Renin-angiotensin system_Homo sapiens_hsa046140.42257717
104Fatty acid degradation_Homo sapiens_hsa000710.41063436
105Arginine and proline metabolism_Homo sapiens_hsa003300.39973017
106Cyanoamino acid metabolism_Homo sapiens_hsa004600.39945742
107p53 signaling pathway_Homo sapiens_hsa041150.38914242
108Cysteine and methionine metabolism_Homo sapiens_hsa002700.37726090
109Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.37659657
110Chemical carcinogenesis_Homo sapiens_hsa052040.37326248
111Leishmaniasis_Homo sapiens_hsa051400.36833781
112RNA transport_Homo sapiens_hsa030130.36233414
113Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.35996991
114Acute myeloid leukemia_Homo sapiens_hsa052210.35942044
115Cell cycle_Homo sapiens_hsa041100.35006149
116Vitamin B6 metabolism_Homo sapiens_hsa007500.34792898
117Circadian rhythm_Homo sapiens_hsa047100.34179175
118beta-Alanine metabolism_Homo sapiens_hsa004100.31949216
119Primary bile acid biosynthesis_Homo sapiens_hsa001200.31697050
120Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.31157042
121Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.31046681
122alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30471847
123Legionellosis_Homo sapiens_hsa051340.29954888
124Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.29705171
125TGF-beta signaling pathway_Homo sapiens_hsa043500.29609826
126Galactose metabolism_Homo sapiens_hsa000520.29045106
127NOD-like receptor signaling pathway_Homo sapiens_hsa046210.28749564
128Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.27943597
129Tyrosine metabolism_Homo sapiens_hsa003500.27836339
130Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.27801565
131Fructose and mannose metabolism_Homo sapiens_hsa000510.27672706
132Phenylalanine metabolism_Homo sapiens_hsa003600.26247507
133Vibrio cholerae infection_Homo sapiens_hsa051100.22148899
134Starch and sucrose metabolism_Homo sapiens_hsa005000.21137801
135Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.18871723
136Tryptophan metabolism_Homo sapiens_hsa003800.17303981
137Collecting duct acid secretion_Homo sapiens_hsa049660.15517805
138Viral carcinogenesis_Homo sapiens_hsa052030.13291289

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