DPM2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. The protein encoded by this gene is a hydrophobic protein that contains 2 predicted transmembrane domains and a putative ER localization signal near the C terminus. This protein associates with DPM1 in vivo and is required for the ER localization and stable expression of DPM1 and also enhances the binding of dolichol-phosphate to DPM1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.44148224
2proteasome assembly (GO:0043248)5.23616321
3DNA deamination (GO:0045006)4.99672904
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.86148718
5energy coupled proton transport, down electrochemical gradient (GO:0015985)4.67009060
6ATP synthesis coupled proton transport (GO:0015986)4.67009060
7chaperone-mediated protein transport (GO:0072321)4.64560416
8proline biosynthetic process (GO:0006561)4.25154097
9ribosomal small subunit biogenesis (GO:0042274)4.22743841
10protein maturation by protein folding (GO:0022417)4.21016559
11respiratory chain complex IV assembly (GO:0008535)4.17743086
12protein complex biogenesis (GO:0070271)4.17402540
13mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.11984174
14SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.08769852
15cotranslational protein targeting to membrane (GO:0006613)4.07055411
16negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.02100140
17heme biosynthetic process (GO:0006783)4.01333648
18termination of RNA polymerase III transcription (GO:0006386)4.00998866
19transcription elongation from RNA polymerase III promoter (GO:0006385)4.00998866
20protein targeting to ER (GO:0045047)4.00466355
21cytochrome complex assembly (GO:0017004)3.96204010
22viral transcription (GO:0019083)3.94939752
23antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.93162282
24protoporphyrinogen IX metabolic process (GO:0046501)3.88719074
25protein localization to endoplasmic reticulum (GO:0070972)3.86801788
26protoporphyrinogen IX biosynthetic process (GO:0006782)3.81642285
27maturation of SSU-rRNA (GO:0030490)3.79561611
28establishment of protein localization to endoplasmic reticulum (GO:0072599)3.78829105
29antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.78750304
30translational termination (GO:0006415)3.78273975
31mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.74712856
32mitochondrial respiratory chain complex I assembly (GO:0032981)3.74712856
33NADH dehydrogenase complex assembly (GO:0010257)3.74712856
34GDP-mannose metabolic process (GO:0019673)3.72807105
35mitochondrial respiratory chain complex assembly (GO:0033108)3.70944270
36peptidyl-histidine modification (GO:0018202)3.70637592
37respiratory electron transport chain (GO:0022904)3.69433523
38regulation of cellular amino acid metabolic process (GO:0006521)3.69081478
39regulation of mitochondrial translation (GO:0070129)3.68296448
40L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.67498056
41negative regulation of ligase activity (GO:0051352)3.66764795
42negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.66764795
43rRNA modification (GO:0000154)3.66724932
44establishment of protein localization to mitochondrial membrane (GO:0090151)3.65472172
45protein localization to mitochondrion (GO:0070585)3.65197539
46DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.64596913
47viral protein processing (GO:0019082)3.62437214
48pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.62006213
49heme metabolic process (GO:0042168)3.60630132
50electron transport chain (GO:0022900)3.60542010
51signal peptide processing (GO:0006465)3.59693336
52signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.55192507
53intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.55192507
54pseudouridine synthesis (GO:0001522)3.53724631
55protein neddylation (GO:0045116)3.53250672
56signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.53097843
57signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.53097843
58signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.53097843
59positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.52854643
60GTP biosynthetic process (GO:0006183)3.52790903
617-methylguanosine mRNA capping (GO:0006370)3.47949361
627-methylguanosine RNA capping (GO:0009452)3.45648350
63RNA capping (GO:0036260)3.45648350
64regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.42600425
65porphyrin-containing compound biosynthetic process (GO:0006779)3.38970205
66translation (GO:0006412)3.37827827
67regulation of ubiquitin-protein transferase activity (GO:0051438)3.37657478
68deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.36613540
69translational elongation (GO:0006414)3.34714221
70signal transduction involved in DNA damage checkpoint (GO:0072422)3.33587318
71signal transduction involved in DNA integrity checkpoint (GO:0072401)3.33587318
72cullin deneddylation (GO:0010388)3.32610120
73guanosine-containing compound biosynthetic process (GO:1901070)3.31891683
74signal transduction involved in cell cycle checkpoint (GO:0072395)3.31271811
75rRNA methylation (GO:0031167)3.27618940
762-deoxyribonucleotide biosynthetic process (GO:0009265)3.25767581
77deoxyribose phosphate biosynthetic process (GO:0046385)3.25767581
78deoxyribonucleoside diphosphate metabolic process (GO:0009186)3.25367460
79oxidative phosphorylation (GO:0006119)3.24774910
80regulation of ligase activity (GO:0051340)3.24555503
81tetrapyrrole biosynthetic process (GO:0033014)3.23955263
82protein deneddylation (GO:0000338)3.20635280
83anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.20194762
84viral life cycle (GO:0019058)3.19479473
85protein-cofactor linkage (GO:0018065)3.17816825
86GMP metabolic process (GO:0046037)3.16514908
87negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.16153760
88protein targeting to mitochondrion (GO:0006626)3.15483911
89cellular response to oxygen radical (GO:0071450)3.12932258
90removal of superoxide radicals (GO:0019430)3.12932258
91cellular response to superoxide (GO:0071451)3.12932258
92porphyrin-containing compound metabolic process (GO:0006778)3.07368409
93establishment of integrated proviral latency (GO:0075713)3.06472139
94deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.05816363
95antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)3.04739527
96DNA strand elongation involved in DNA replication (GO:0006271)3.03317753
97cellular protein complex disassembly (GO:0043624)3.03233635
98UTP biosynthetic process (GO:0006228)3.01450609
99pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.00422285
100establishment of protein localization to mitochondrion (GO:0072655)2.99370238
101nucleobase-containing small molecule interconversion (GO:0015949)2.98120974
102oxygen transport (GO:0015671)2.96516799
103iron-sulfur cluster assembly (GO:0016226)2.95415950
104metallo-sulfur cluster assembly (GO:0031163)2.95415950
105negative regulation of protein ubiquitination (GO:0031397)2.95025131
106spliceosomal snRNP assembly (GO:0000387)2.94859499
107positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.93726756
108translational initiation (GO:0006413)2.92108082
109maturation of 5.8S rRNA (GO:0000460)2.91582023
110DNA strand elongation (GO:0022616)2.91561412
111pentose metabolic process (GO:0019321)2.90991963
112nucleoside salvage (GO:0043174)2.90543791
113establishment of viral latency (GO:0019043)2.89600439
114positive regulation of ligase activity (GO:0051351)2.88836399
115cellular component biogenesis (GO:0044085)2.88142335
116COPI coating of Golgi vesicle (GO:0048205)2.87497890
117Golgi transport vesicle coating (GO:0048200)2.87497890
118nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.87354197
119ribosomal large subunit biogenesis (GO:0042273)2.87065639
120negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.86071194
121regulation of cellular amine metabolic process (GO:0033238)2.84302290
122pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.84017892
123telomere maintenance via semi-conservative replication (GO:0032201)2.83786972
124exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.78133968
125positive regulation of cell cycle arrest (GO:0071158)2.76984919
126CTP biosynthetic process (GO:0006241)2.74437008
127CTP metabolic process (GO:0046036)2.74437008
128transcription-coupled nucleotide-excision repair (GO:0006283)2.71240768
129DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.71214305
130sequestering of actin monomers (GO:0042989)2.69414858
131deoxyribonucleotide biosynthetic process (GO:0009263)2.69213545
132RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.68534780
133tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.68534780
134ribonucleoprotein complex biogenesis (GO:0022613)2.67824848

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.04381730
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.72248783
3* GABP_17652178_ChIP-ChIP_JURKAT_Human4.60155897
4* JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.14737765
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.11569400
6* EST1_17652178_ChIP-ChIP_JURKAT_Human4.05303251
7ELF1_17652178_ChIP-ChIP_JURKAT_Human3.69028603
8* ETS1_20019798_ChIP-Seq_JURKAT_Human3.40889760
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.37533540
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.30823975
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.17172205
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.11556041
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.09871098
14MYC_18555785_ChIP-Seq_MESCs_Mouse3.06759220
15PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.84683793
16SRF_21415370_ChIP-Seq_HL-1_Mouse2.70609389
17* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.68326782
18VDR_23849224_ChIP-Seq_CD4+_Human2.65630874
19* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.62668686
20* THAP11_20581084_ChIP-Seq_MESCs_Mouse2.51669121
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.40449772
22SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.34035568
23* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.30870104
24DCP1A_22483619_ChIP-Seq_HELA_Human2.23578700
25FOXP3_21729870_ChIP-Seq_TREG_Human2.12342284
26YY1_21170310_ChIP-Seq_MESCs_Mouse2.11143659
27FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.08916113
28CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.06723169
29* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.06464006
30IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.06442699
31* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.06134273
32ELK1_19687146_ChIP-ChIP_HELA_Human2.05113433
33HOXB4_20404135_ChIP-ChIP_EML_Mouse2.03606811
34IRF8_21731497_ChIP-ChIP_J774_Mouse2.01508880
35* GABP_19822575_ChIP-Seq_HepG2_Human1.96951067
36SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.95137962
37XRN2_22483619_ChIP-Seq_HELA_Human1.91970348
38BP1_19119308_ChIP-ChIP_Hs578T_Human1.87948720
39CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.79654584
40TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.76647184
41TTF2_22483619_ChIP-Seq_HELA_Human1.75418971
42* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.72132252
43DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.70588802
44MYC_19079543_ChIP-ChIP_MESCs_Mouse1.67631500
45IRF8_22096565_ChIP-ChIP_GC-B_Human1.60548982
46ELK1_22589737_ChIP-Seq_MCF10A_Human1.57318731
47CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.57207523
48ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.56674696
49TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53320947
50* KDM5A_27292631_Chip-Seq_BREAST_Human1.52730729
51SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.50000341
52TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48231035
53NELFA_20434984_ChIP-Seq_ESCs_Mouse1.48173682
54SPI1_23547873_ChIP-Seq_NB4_Human1.38105175
55PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.37282117
56VDR_21846776_ChIP-Seq_THP-1_Human1.37085124
57LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.36025620
58DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.33805563
59PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29668558
60STAT4_19710469_ChIP-ChIP_TH1__Mouse1.28701527
61SRY_22984422_ChIP-ChIP_TESTIS_Rat1.28430322
62RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.25375066
63IRF1_19129219_ChIP-ChIP_H3396_Human1.25012030
64CTCF_18555785_ChIP-Seq_MESCs_Mouse1.22122141
65MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.21425602
66TET1_21451524_ChIP-Seq_MESCs_Mouse1.21136956
67ZNF263_19887448_ChIP-Seq_K562_Human1.20651983
68ELF1_20517297_ChIP-Seq_JURKAT_Human1.16091585
69FOXP1_21924763_ChIP-Seq_HESCs_Human1.15662681
70E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.15646894
71CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.15219785
72SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.14718020
73GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.14374045
74CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.14020738
75MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.13150090
76P68_20966046_ChIP-Seq_HELA_Human1.11581358
77* BCL6_27268052_Chip-Seq_Bcells_Human1.10274892
78MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.09590796
79FOXM1_23109430_ChIP-Seq_U2OS_Human1.09070967
80MYC_22102868_ChIP-Seq_BL_Human1.07095298
81EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.05645597
82NANOG_18555785_ChIP-Seq_MESCs_Mouse1.04909172
83YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04244955
84* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03979332
85BCOR_27268052_Chip-Seq_Bcells_Human1.03833337
86MYC_18940864_ChIP-ChIP_HL60_Human1.03643614
87MAF_26560356_Chip-Seq_TH2_Human1.03296096
88POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.03266899
89STAT3_1855785_ChIP-Seq_MESCs_Mouse1.03217057
90KLF4_18555785_ChIP-Seq_MESCs_Mouse1.03034917
91TBX5_21415370_ChIP-Seq_HL-1_Mouse1.02011314
92NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.01870172
93MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.01479257
94HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.98140022
95* LXR_22292898_ChIP-Seq_THP-1_Human0.98080941
96CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.98033281
97BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.97595461
98LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.96714470
99* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.96105809
100ELK3_25401928_ChIP-Seq_HUVEC_Human0.95351497
101PU.1_20513432_ChIP-Seq_Bcells_Mouse0.95122351
102TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.93700069
103NOTCH1_21737748_ChIP-Seq_TLL_Human0.92334020
104E2F1_21310950_ChIP-Seq_MCF-7_Human0.92305288
105* ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.92146490
106TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92124391
107E2F4_17652178_ChIP-ChIP_JURKAT_Human0.91960970
108CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.91800512
109* PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.91211113
110FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.90851560
111ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.90775463
112KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.90677371
113MYCN_18555785_ChIP-Seq_MESCs_Mouse0.90495577
114ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.90031292
115* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.86802046
116MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.85931735
117TFEB_21752829_ChIP-Seq_HELA_Human0.85677759
118CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84937159
119PADI4_21655091_ChIP-ChIP_MCF-7_Human0.84383891
120CIITA_25753668_ChIP-Seq_RAJI_Human0.83016127
121CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.81947761
122* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.81908973
123E2F7_22180533_ChIP-Seq_HELA_Human0.81779224
124SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.81196636
125VDR_22108803_ChIP-Seq_LS180_Human0.80239085
126RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.78431281
127SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.77756840
128CTCF_26484167_Chip-Seq_Bcells_Mouse0.74902573
129PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.74329927
130HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.73656073
131YY1_22570637_ChIP-Seq_MALME-3M_Human0.73161512
132CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.72578780
133GATA1_22383799_ChIP-Seq_G1ME_Mouse0.71145169

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis4.63784056
2MP0009379_abnormal_foot_pigmentation3.35526626
3MP0003111_abnormal_nucleus_morphology3.30794701
4MP0005083_abnormal_biliary_tract2.97039749
5MP0001986_abnormal_taste_sensitivity2.95724806
6MP0002148_abnormal_hypersensitivity_rea2.88044721
7MP0009785_altered_susceptibility_to2.74523912
8MP0003656_abnormal_erythrocyte_physiolo2.52724348
9MP0001835_abnormal_antigen_presentation2.48604640
10MP0001529_abnormal_vocalization2.45042898
11MP0005671_abnormal_response_to2.32232408
12MP0003880_abnormal_central_pattern2.31135084
13MP0006292_abnormal_olfactory_placode2.28563830
14MP0002638_abnormal_pupillary_reflex2.11351953
15MP0005058_abnormal_lysosome_morphology2.09948930
16MP0000372_irregular_coat_pigmentation2.08648128
17MP0003724_increased_susceptibility_to2.06734844
18MP0003693_abnormal_embryo_hatching1.99044002
19MP0001905_abnormal_dopamine_level1.98459422
20MP0001188_hyperpigmentation1.94782179
21MP0005000_abnormal_immune_tolerance1.93754774
22MP0003186_abnormal_redox_activity1.91480542
23MP0000015_abnormal_ear_pigmentation1.83981780
24MP0000358_abnormal_cell_content/1.82688936
25MP0005025_abnormal_response_to1.82266249
26MP0005075_abnormal_melanosome_morpholog1.81990156
27MP0003763_abnormal_thymus_physiology1.80178187
28MP0000685_abnormal_immune_system1.77908984
29MP0009333_abnormal_splenocyte_physiolog1.73152265
30MP0008058_abnormal_DNA_repair1.72262474
31MP0002132_abnormal_respiratory_system1.68141843
32MP0005174_abnormal_tail_pigmentation1.66626619
33MP0002163_abnormal_gland_morphology1.65016794
34MP0002420_abnormal_adaptive_immunity1.64124172
35MP0001819_abnormal_immune_cell1.63887693
36MP0002723_abnormal_immune_serum1.63221489
37MP0002419_abnormal_innate_immunity1.60950194
38MP0005451_abnormal_body_composition1.59964639
39MP0002876_abnormal_thyroid_physiology1.59256084
40MP0003191_abnormal_cellular_cholesterol1.57065264
41MP0006082_CNS_inflammation1.55258480
42MP0002452_abnormal_antigen_presenting1.54149067
43MP0001542_abnormal_bone_strength1.53753842
44MP0009840_abnormal_foam_cell1.51352705
45MP0005397_hematopoietic_system_phenotyp1.46552229
46MP0001545_abnormal_hematopoietic_system1.46552229
47MP0004957_abnormal_blastocyst_morpholog1.45485284
48MP0000681_abnormal_thyroid_gland1.45152328
49MP0000313_abnormal_cell_death1.43651931
50MP0008995_early_reproductive_senescence1.42411692
51MP0005645_abnormal_hypothalamus_physiol1.40495552
52MP0004142_abnormal_muscle_tone1.39013703
53MP0005379_endocrine/exocrine_gland_phen1.37182064
54MP0001800_abnormal_humoral_immune1.35316924
55MP0005387_immune_system_phenotype1.34899538
56MP0001790_abnormal_immune_system1.34899538
57MP0002019_abnormal_tumor_incidence1.34559311
58MP0001853_heart_inflammation1.31118592
59MP0002095_abnormal_skin_pigmentation1.28522521
60MP0002933_joint_inflammation1.25517277
61MP0003436_decreased_susceptibility_to1.25373116
62MP0002398_abnormal_bone_marrow1.25077815
63MP0002736_abnormal_nociception_after1.24837500
64MP0005084_abnormal_gallbladder_morpholo1.23924644
65MP0000678_abnormal_parathyroid_gland1.23447272
66MP0005501_abnormal_skin_physiology1.22432945
67MP0003136_yellow_coat_color1.21131316
68MP0004147_increased_porphyrin_level1.21102295
69MP0009278_abnormal_bone_marrow1.20748149
70MP0005171_absent_coat_pigmentation1.20041766
71MP0000716_abnormal_immune_system1.18201263
72MP0008875_abnormal_xenobiotic_pharmacok1.17468641
73MP0001730_embryonic_growth_arrest1.17171475
74MP0008932_abnormal_embryonic_tissue1.16158264
75MP0010386_abnormal_urinary_bladder1.15631908
76MP0002405_respiratory_system_inflammati1.11770808
77MP0003786_premature_aging1.09276638
78MP0001873_stomach_inflammation1.09188098
79MP0006036_abnormal_mitochondrial_physio1.09066887
80MP0005408_hypopigmentation1.08871009
81MP0002877_abnormal_melanocyte_morpholog1.08600153
82MP0005646_abnormal_pituitary_gland1.08130077
83MP0000350_abnormal_cell_proliferation1.06622274
84MP0002429_abnormal_blood_cell1.05507520
85MP0001727_abnormal_embryo_implantation1.04040790
86MP0008260_abnormal_autophagy1.03163425
87MP0005332_abnormal_amino_acid1.02728698
88MP0005410_abnormal_fertilization1.02306018
89MP0002938_white_spotting1.01827080
90MP0004782_abnormal_surfactant_physiolog1.01226839
91MP0000689_abnormal_spleen_morphology1.00741121
92MP0001764_abnormal_homeostasis1.00525518
93MP0002751_abnormal_autonomic_nervous1.00367758
94MP0002080_prenatal_lethality0.99831200
95MP0000703_abnormal_thymus_morphology0.99676077
96MP0003866_abnormal_defecation0.99517924
97MP0005409_darkened_coat_color0.98671420
98MP0008007_abnormal_cellular_replicative0.98144741
99MP0005330_cardiomyopathy0.98075888
100MP0002277_abnormal_respiratory_mucosa0.97073493
101MP0003718_maternal_effect0.96834759
102MP0001845_abnormal_inflammatory_respons0.94217102
103MP0002722_abnormal_immune_system0.94210871
104MP0003123_paternal_imprinting0.94102888
105MP0001881_abnormal_mammary_gland0.94058876
106MP0000343_altered_response_to0.94012559
107MP0002653_abnormal_ependyma_morphology0.93821752
108MP0004381_abnormal_hair_follicle0.93613850
109MP0001984_abnormal_olfaction0.93564872
110MP0003077_abnormal_cell_cycle0.93024616
111MP0002272_abnormal_nervous_system0.92195241
112MP0005310_abnormal_salivary_gland0.88594583
113MP0005584_abnormal_enzyme/coenzyme_acti0.88299200
114MP0005319_abnormal_enzyme/_coenzyme0.87818032
115MP0000490_abnormal_crypts_of0.86765437
116MP0008873_increased_physiological_sensi0.86331642
117MP0003879_abnormal_hair_cell0.85818563
118MP0001661_extended_life_span0.85218983
119MP0006276_abnormal_autonomic_nervous0.84415836
120MP0000858_altered_metastatic_potential0.83269329
121MP0008872_abnormal_physiological_respon0.83200072
122MP0005636_abnormal_mineral_homeostasis0.83081126
123MP0000750_abnormal_muscle_regeneration0.82766828
124MP0000920_abnormal_myelination0.81917550
125MP0002693_abnormal_pancreas_physiology0.81849625
126MP0004233_abnormal_muscle_weight0.81543474
127MP0008789_abnormal_olfactory_epithelium0.81463765
128MP0001968_abnormal_touch/_nociception0.80202512
129MP0008469_abnormal_protein_level0.79995203
130MP0010094_abnormal_chromosome_stability0.79144525
131MP0003172_abnormal_lysosome_physiology0.78721584
132MP0002396_abnormal_hematopoietic_system0.78639380
133MP0009765_abnormal_xenobiotic_induced0.78347187
134MP0003950_abnormal_plasma_membrane0.78228830
135MP0005464_abnormal_platelet_physiology0.75846412
136MP0002210_abnormal_sex_determination0.74744056
137MP0001533_abnormal_skeleton_physiology0.74456793
138MP0001929_abnormal_gametogenesis0.72607495
139MP0001697_abnormal_embryo_size0.72076770
140MP0009763_increased_sensitivity_to0.71053002
141MP0001851_eye_inflammation0.71051961
142MP0005384_cellular_phenotype0.70680380
143MP0009697_abnormal_copulation0.70047378
144MP0006035_abnormal_mitochondrial_morpho0.69754784
145MP0004510_myositis0.69469319
146MP0001970_abnormal_pain_threshold0.69172772

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.94564551
2Mitochondrial inheritance (HP:0001427)4.83895553
3Increased hepatocellular lipid droplets (HP:0006565)4.61120892
4Abnormal mitochondria in muscle tissue (HP:0008316)4.57742879
5Hepatocellular necrosis (HP:0001404)4.19196291
6Renal Fanconi syndrome (HP:0001994)4.12552737
7Increased CSF lactate (HP:0002490)4.08239212
8Acute encephalopathy (HP:0006846)4.06660692
9Testicular atrophy (HP:0000029)4.01690261
10Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.94808024
11Lipid accumulation in hepatocytes (HP:0006561)3.93801192
12Progressive macrocephaly (HP:0004481)3.89917911
13Exertional dyspnea (HP:0002875)3.81250464
143-Methylglutaconic aciduria (HP:0003535)3.77720520
15Abnormality of cells of the erythroid lineage (HP:0012130)3.68541780
16Hepatic necrosis (HP:0002605)3.63620781
17Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.55336485
18Abnormal number of erythroid precursors (HP:0012131)3.54330709
19Cholecystitis (HP:0001082)3.52272205
20Abnormal gallbladder physiology (HP:0012438)3.52272205
21Decreased activity of mitochondrial respiratory chain (HP:0008972)3.49445162
22Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.49445162
23Type I transferrin isoform profile (HP:0003642)3.41619917
24Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.18196999
25Increased intramyocellular lipid droplets (HP:0012240)3.17964135
26Poor head control (HP:0002421)3.15108458
27Reticulocytopenia (HP:0001896)3.07908417
28Increased serum lactate (HP:0002151)3.04046053
29Abnormal hemoglobin (HP:0011902)3.01439655
30Cholelithiasis (HP:0001081)3.00707795
31Aplastic anemia (HP:0001915)3.00700820
32Abnormal gallbladder morphology (HP:0012437)2.78197156
33Exercise intolerance (HP:0003546)2.76578638
34Abnormality of renal resorption (HP:0011038)2.69753730
35Respiratory difficulties (HP:0002880)2.67820372
36Lactic acidosis (HP:0003128)2.61822290
37Respiratory failure (HP:0002878)2.60341447
38Optic disc pallor (HP:0000543)2.56206690
39Elevated erythrocyte sedimentation rate (HP:0003565)2.56167176
40Increased muscle lipid content (HP:0009058)2.53565304
41Petechiae (HP:0000967)2.52643426
42Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.52192318
43Abnormal protein N-linked glycosylation (HP:0012347)2.52192318
44Abnormal protein glycosylation (HP:0012346)2.52192318
45Abnormal glycosylation (HP:0012345)2.52192318
46Hypothermia (HP:0002045)2.50192694
47Abnormal hair whorl (HP:0010721)2.49201886
48Increased serum pyruvate (HP:0003542)2.48311930
49Abnormality of glycolysis (HP:0004366)2.48311930
50Aplasia/Hypoplasia of the sacrum (HP:0008517)2.48022973
51Leukodystrophy (HP:0002415)2.46481964
52Recurrent abscess formation (HP:0002722)2.45480838
53Microretrognathia (HP:0000308)2.41965211
54Ragged-red muscle fibers (HP:0003200)2.39996463
55Degeneration of anterior horn cells (HP:0002398)2.36686901
56Abnormality of the anterior horn cell (HP:0006802)2.36686901
57Pallor (HP:0000980)2.35494878
58Increased IgM level (HP:0003496)2.34708923
59Macrocytic anemia (HP:0001972)2.31371370
60Birth length less than 3rd percentile (HP:0003561)2.30888995
61Progressive microcephaly (HP:0000253)2.29992718
62Reticulocytosis (HP:0001923)2.29688697
63Hypochromic microcytic anemia (HP:0004840)2.26956044
64Severe visual impairment (HP:0001141)2.23913134
65Abnormality of the gallbladder (HP:0005264)2.23795585
66Spastic paraparesis (HP:0002313)2.20856155
67Lethargy (HP:0001254)2.18227890
68Ileus (HP:0002595)2.17781152
69True hermaphroditism (HP:0010459)2.17776474
70Medial flaring of the eyebrow (HP:0010747)2.17598097
71Reduced antithrombin III activity (HP:0001976)2.17228828
72Opisthotonus (HP:0002179)2.15097202
73Stomatitis (HP:0010280)2.12416169
74Upper limb muscle weakness (HP:0003484)2.11524149
75Abnormality of reticulocytes (HP:0004312)2.11419746
76Delusions (HP:0000746)2.11241652
77Abnormality of dicarboxylic acid metabolism (HP:0010995)2.08819297
78Dicarboxylic aciduria (HP:0003215)2.08819297
79Abnormality of the heme biosynthetic pathway (HP:0010472)2.08183133
80Congenital ichthyosiform erythroderma (HP:0007431)2.08155175
81Recurrent bacterial skin infections (HP:0005406)2.07303407
82Oral leukoplakia (HP:0002745)2.02860337
83Generalized aminoaciduria (HP:0002909)2.02673835
84Abnormality of aromatic amino acid family metabolism (HP:0004338)1.99589420
85Irregular epiphyses (HP:0010582)1.98143853
86Hyperphosphaturia (HP:0003109)1.97008621
87Progressive muscle weakness (HP:0003323)1.96328285
88Cerebral palsy (HP:0100021)1.94635530
89Hypertensive crisis (HP:0100735)1.94391773
90Hypokinesia (HP:0002375)1.94246272
91Parakeratosis (HP:0001036)1.94153893
92Secondary amenorrhea (HP:0000869)1.91944396
93Pancytopenia (HP:0001876)1.90161345
94IgG deficiency (HP:0004315)1.89983956
95Squamous cell carcinoma (HP:0002860)1.89033397
96Cerebral edema (HP:0002181)1.87503201
97Decreased electroretinogram (ERG) amplitude (HP:0000654)1.87490072
98Increased serum ferritin (HP:0003281)1.87403662
99Methylmalonic acidemia (HP:0002912)1.86482097
100Paralysis (HP:0003470)1.86480941
101Rough bone trabeculation (HP:0100670)1.86265196
10211 pairs of ribs (HP:0000878)1.85881446
103Vacuolated lymphocytes (HP:0001922)1.85522714
104Myositis (HP:0100614)1.85204381
105Microvesicular hepatic steatosis (HP:0001414)1.84858909
106Acute hepatic failure (HP:0006554)1.83618089
107IgM deficiency (HP:0002850)1.83080439
108Renal tubular dysfunction (HP:0000124)1.83054282
109Dysautonomia (HP:0002459)1.82914894
110Prolonged neonatal jaundice (HP:0006579)1.82505852
111Nausea (HP:0002018)1.82274557
112Abnormality of urine glucose concentration (HP:0011016)1.81243863
113Glycosuria (HP:0003076)1.81243863
114Abnormality of dental color (HP:0011073)1.80964346
115Cerebral hypomyelination (HP:0006808)1.80820149
116Hepatosplenomegaly (HP:0001433)1.80645011
117Hyperbilirubinemia (HP:0002904)1.80029967
118Cleft eyelid (HP:0000625)1.78789655
119Neuroendocrine neoplasm (HP:0100634)1.78696380
120Premature graying of hair (HP:0002216)1.78613866
121Type 2 muscle fiber atrophy (HP:0003554)1.78158087
122Abnormality of macrophages (HP:0004311)1.77531981
123Neutropenia (HP:0001875)1.74848113
124Progressive neurologic deterioration (HP:0002344)1.73345700
125Poor suck (HP:0002033)1.73229336
126Absent rod-and cone-mediated responses on ERG (HP:0007688)1.71236328
127Sparse eyelashes (HP:0000653)1.71184848
128Pancreatic cysts (HP:0001737)1.70137981
129Microcytic anemia (HP:0001935)1.69809643
130Nephrogenic diabetes insipidus (HP:0009806)1.69094213
131Premature ovarian failure (HP:0008209)1.68990591
132Muscle fiber atrophy (HP:0100295)1.63519704
133CNS demyelination (HP:0007305)1.61905249
134Mediastinal lymphadenopathy (HP:0100721)1.59481139
135Eczematoid dermatitis (HP:0000976)1.58655008
136Stenosis of the external auditory canal (HP:0000402)1.58478764
137Pancreatic fibrosis (HP:0100732)1.57908203
138Methylmalonic aciduria (HP:0012120)1.57678688
139Abnormality of magnesium homeostasis (HP:0004921)1.56995607
140Congenital primary aphakia (HP:0007707)1.56305663
141Emotional lability (HP:0000712)1.55810719
142Purpura (HP:0000979)1.55596080
143Abnormal trabecular bone morphology (HP:0100671)1.55577635

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.46296796
2STK164.00827970
3MAP3K123.42311819
4NME23.40546197
5BUB13.21797807
6PIM22.52434352
7SRPK12.50887199
8VRK12.41455291
9ARAF2.28049476
10IRAK42.18808284
11TESK22.12803783
12NME12.11412326
13CDK192.08918118
14EIF2AK12.04972658
15PBK2.04089670
16EIF2AK31.96270885
17TXK1.78581810
18BMPR21.76660558
19BRAF1.60662184
20TNIK1.59769492
21IRAK31.57654138
22TAOK21.55097791
23KIT1.51549270
24MYLK1.51331729
25SCYL21.50504612
26CASK1.49223263
27PDK21.43189623
28TRIM281.39496858
29MAP2K71.36912399
30DYRK21.36614484
31NEK11.35469057
32PAK41.33140519
33EPHA21.26758650
34BMPR1B1.26636138
35TSSK61.22072278
36SMG11.19723725
37SIK31.18394608
38MST41.18045079
39MUSK1.15695124
40TEC1.15611352
41ADRBK21.14757003
42LIMK11.14455123
43ZAP701.13264254
44CDC71.11592300
45WEE11.11165278
46SYK1.10003612
47MKNK11.08954703
48TESK11.08446110
49MAPKAPK31.08371580
50TAOK11.07838939
51BLK1.06342745
52MAP4K21.04149818
53GRK61.03115345
54CLK11.02624609
55PRPF4B1.02247478
56ERN10.98825332
57CCNB10.96854127
58MAP4K10.95698745
59PLK10.91251574
60MAP3K140.90992800
61RIPK40.90344993
62MAP2K30.89807930
63TTK0.87879476
64CSNK1A1L0.86514335
65TBK10.86349758
66ERBB30.83335769
67IRAK20.82875191
68BRSK20.82496861
69EIF2AK20.81430485
70BMX0.80627649
71LMTK20.80205633
72LRRK20.79981095
73TLK10.79976722
74ILK0.77999187
75ACVR1B0.76680909
76MAPKAPK50.75942024
77CDK70.74710687
78BCR0.74604005
79MAP3K30.74369200
80NLK0.74257910
81OXSR10.73679662
82ATR0.72842941
83DAPK10.71997243
84CDK80.70765135
85BTK0.70745787
86CSNK1G10.70112179
87MAP3K80.69932670
88YES10.69891513
89TNK20.69682988
90STK40.69434717
91IKBKB0.68230838
92IKBKE0.68212303
93NUAK10.67805267
94AURKB0.66822682
95LYN0.66056387
96MAP3K110.63933592
97PLK40.63637802
98GRK70.63554200
99KDR0.61529511
100IRAK10.61355527
101AURKA0.61194943
102MKNK20.60258439
103CHEK20.59897930
104MAPK130.59893835
105PLK20.55773317
106CSNK1G20.55692415
107CSNK2A10.55186541
108BCKDK0.53697360
109BRSK10.52057892
110STK100.51581787
111PLK30.51234083
112DYRK30.51072843
113WNK40.51015522
114PRKCI0.49152965
115ABL20.49041077
116ZAK0.48979161
117PASK0.47691090
118GRK50.46371082
119RPS6KA50.45776171
120MST1R0.44086003
121UHMK10.42359692
122DAPK30.42213253
123MAP2K20.40974850
124PRKCD0.40969658
125RPS6KB20.40875502
126CSNK1G30.40119957
127PRKD30.39365548
128MAP2K60.38604024
129CDK140.38283342
130LCK0.38075875
131CAMK2B0.37992807
132PAK10.37377200
133TIE10.37024310
134CSNK2A20.36378523
135PRKD20.36254522
136RPS6KA40.34191656
137CHEK10.33473003
138NEK60.33125885
139RAF10.32912348
140CDK180.32284924
141PRKCE0.31660424
142CDK11A0.31624663
143MOS0.29530367
144MATK0.28166686
145TAF10.28127986
146MAP3K50.27518586

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.45280060
2Ribosome_Homo sapiens_hsa030104.25504118
3Oxidative phosphorylation_Homo sapiens_hsa001903.93797967
4Protein export_Homo sapiens_hsa030603.75389460
5RNA polymerase_Homo sapiens_hsa030203.36640874
6Parkinsons disease_Homo sapiens_hsa050123.29982566
7Sulfur relay system_Homo sapiens_hsa041222.81664392
8DNA replication_Homo sapiens_hsa030302.46748706
9Huntingtons disease_Homo sapiens_hsa050162.34942365
10Alzheimers disease_Homo sapiens_hsa050102.31269219
11Pyrimidine metabolism_Homo sapiens_hsa002402.24569776
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.23090693
13Homologous recombination_Homo sapiens_hsa034402.02872692
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.92132936
15SNARE interactions in vesicular transport_Homo sapiens_hsa041301.86445596
16Mismatch repair_Homo sapiens_hsa034301.81559380
17Base excision repair_Homo sapiens_hsa034101.80281702
18Nucleotide excision repair_Homo sapiens_hsa034201.67526394
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.63143003
20Spliceosome_Homo sapiens_hsa030401.62307929
21Collecting duct acid secretion_Homo sapiens_hsa049661.57720333
22Basal transcription factors_Homo sapiens_hsa030221.56054484
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.54795541
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.50440712
25One carbon pool by folate_Homo sapiens_hsa006701.50071598
26Biosynthesis of amino acids_Homo sapiens_hsa012301.48173747
27Vibrio cholerae infection_Homo sapiens_hsa051101.45066755
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.42407113
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.38713467
30Purine metabolism_Homo sapiens_hsa002301.33869007
31Rheumatoid arthritis_Homo sapiens_hsa053231.31596513
32Allograft rejection_Homo sapiens_hsa053301.24730617
33Graft-versus-host disease_Homo sapiens_hsa053321.23952733
34* Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.19909692
35Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.17448810
36Carbon metabolism_Homo sapiens_hsa012001.15473446
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.06779440
38Asthma_Homo sapiens_hsa053101.06558712
39Pyruvate metabolism_Homo sapiens_hsa006201.05922145
40Primary immunodeficiency_Homo sapiens_hsa053401.03860822
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.03655199
42Vitamin B6 metabolism_Homo sapiens_hsa007501.01327419
43Type I diabetes mellitus_Homo sapiens_hsa049400.99836741
44RNA degradation_Homo sapiens_hsa030180.99681627
45Folate biosynthesis_Homo sapiens_hsa007900.99173447
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.94750461
47Arachidonic acid metabolism_Homo sapiens_hsa005900.90101791
48Cardiac muscle contraction_Homo sapiens_hsa042600.89170171
49Sphingolipid metabolism_Homo sapiens_hsa006000.89050946
50Phagosome_Homo sapiens_hsa041450.88653174
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.88217300
52Hematopoietic cell lineage_Homo sapiens_hsa046400.82822101
53Epstein-Barr virus infection_Homo sapiens_hsa051690.82528259
54Non-homologous end-joining_Homo sapiens_hsa034500.79430015
55Autoimmune thyroid disease_Homo sapiens_hsa053200.78292841
56Fanconi anemia pathway_Homo sapiens_hsa034600.78238389
57RNA transport_Homo sapiens_hsa030130.76905806
58Intestinal immune network for IgA production_Homo sapiens_hsa046720.75635237
59Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.74771915
60Other glycan degradation_Homo sapiens_hsa005110.74385832
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74164623
62Antigen processing and presentation_Homo sapiens_hsa046120.73392159
63Drug metabolism - other enzymes_Homo sapiens_hsa009830.71694601
64Peroxisome_Homo sapiens_hsa041460.71382512
65Fatty acid elongation_Homo sapiens_hsa000620.70422378
66Synaptic vesicle cycle_Homo sapiens_hsa047210.69268462
67Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68246292
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64324811
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63982894
70Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.63348911
71Regulation of autophagy_Homo sapiens_hsa041400.62900403
72* N-Glycan biosynthesis_Homo sapiens_hsa005100.62646078
73Sulfur metabolism_Homo sapiens_hsa009200.61709377
74Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.61564587
75Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60716629
76Ether lipid metabolism_Homo sapiens_hsa005650.58911262
77* Metabolic pathways_Homo sapiens_hsa011000.57717919
78Legionellosis_Homo sapiens_hsa051340.57110704
79Lysosome_Homo sapiens_hsa041420.56283147
80Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.56157598
81Cell cycle_Homo sapiens_hsa041100.55917782
82Phototransduction_Homo sapiens_hsa047440.54717859
83Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54564895
84Cyanoamino acid metabolism_Homo sapiens_hsa004600.54088628
85Maturity onset diabetes of the young_Homo sapiens_hsa049500.53181558
86Shigellosis_Homo sapiens_hsa051310.52597458
87Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.52574962
88Leishmaniasis_Homo sapiens_hsa051400.50829884
89Malaria_Homo sapiens_hsa051440.50352199
90RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.47870973
91NF-kappa B signaling pathway_Homo sapiens_hsa040640.47808886
92Linoleic acid metabolism_Homo sapiens_hsa005910.47609550
93Pertussis_Homo sapiens_hsa051330.46726504
94Measles_Homo sapiens_hsa051620.46523297
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45766089
96Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.44148028
97mRNA surveillance pathway_Homo sapiens_hsa030150.43438595
98Herpes simplex infection_Homo sapiens_hsa051680.42504224
99Fatty acid metabolism_Homo sapiens_hsa012120.42032824
100Glutathione metabolism_Homo sapiens_hsa004800.40872012
101Serotonergic synapse_Homo sapiens_hsa047260.40847363
102NOD-like receptor signaling pathway_Homo sapiens_hsa046210.40495117
103Steroid biosynthesis_Homo sapiens_hsa001000.38801883
104Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.38507593
105p53 signaling pathway_Homo sapiens_hsa041150.37730176
106Fructose and mannose metabolism_Homo sapiens_hsa000510.37236498
107Propanoate metabolism_Homo sapiens_hsa006400.35381131
108Tyrosine metabolism_Homo sapiens_hsa003500.35276588
109Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34498015
110Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.33187602
111Glycosaminoglycan degradation_Homo sapiens_hsa005310.32046835
112Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31619497
113Salmonella infection_Homo sapiens_hsa051320.31450835
114Arginine and proline metabolism_Homo sapiens_hsa003300.31189456
115Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.29894314
116Pentose phosphate pathway_Homo sapiens_hsa000300.29859274
117Toll-like receptor signaling pathway_Homo sapiens_hsa046200.29766041
118Tuberculosis_Homo sapiens_hsa051520.29357302
119alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26386728
120Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.26148154
121Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.25823675
122Galactose metabolism_Homo sapiens_hsa000520.24245126
123Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.20743516
124Nicotine addiction_Homo sapiens_hsa050330.19977051
125Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.18947270
126Apoptosis_Homo sapiens_hsa042100.18838324
127Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.18504471
128Influenza A_Homo sapiens_hsa051640.18429715
129Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.15875488
130Selenocompound metabolism_Homo sapiens_hsa004500.12689349
131Oocyte meiosis_Homo sapiens_hsa041140.12536638
132Phenylalanine metabolism_Homo sapiens_hsa003600.12438887
133Primary bile acid biosynthesis_Homo sapiens_hsa001200.08710585

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