DPP10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Mutations in this gene have been associated with asthma. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.48382864
2neuron cell-cell adhesion (GO:0007158)5.24457591
3vocalization behavior (GO:0071625)5.19023382
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.18356604
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.02461032
6synaptic vesicle exocytosis (GO:0016079)4.83830079
7neuronal action potential propagation (GO:0019227)4.70247487
8ionotropic glutamate receptor signaling pathway (GO:0035235)4.69453524
9glutamate secretion (GO:0014047)4.69188526
10regulation of glutamate receptor signaling pathway (GO:1900449)4.66118201
11regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.59902590
12regulation of synaptic vesicle exocytosis (GO:2000300)4.52746419
13locomotory exploration behavior (GO:0035641)4.50246466
14protein localization to synapse (GO:0035418)4.49576729
15positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.44793743
16positive regulation of dendritic spine morphogenesis (GO:0061003)4.38157095
17C4-dicarboxylate transport (GO:0015740)4.38018949
18glutamate receptor signaling pathway (GO:0007215)4.33553864
19synaptic vesicle maturation (GO:0016188)4.31648270
20presynaptic membrane assembly (GO:0097105)4.30419108
21synaptic vesicle docking involved in exocytosis (GO:0016081)4.19595329
22synaptic transmission, glutamatergic (GO:0035249)4.13297352
23neuron-neuron synaptic transmission (GO:0007270)4.11630261
24gamma-aminobutyric acid signaling pathway (GO:0007214)4.08321549
25negative regulation of synaptic transmission, GABAergic (GO:0032229)4.06138893
26short-term memory (GO:0007614)4.02441108
27presynaptic membrane organization (GO:0097090)3.98141283
28postsynaptic membrane organization (GO:0001941)3.95361407
29neurotransmitter secretion (GO:0007269)3.95322491
30regulation of synaptic vesicle transport (GO:1902803)3.94764431
31neurotransmitter-gated ion channel clustering (GO:0072578)3.90915298
32pyrimidine nucleobase catabolic process (GO:0006208)3.85923761
33regulation of pigment cell differentiation (GO:0050932)3.85503058
34L-amino acid import (GO:0043092)3.84622423
35regulation of cilium movement (GO:0003352)3.77338701
36G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.73553001
37regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.71917248
38cerebellar Purkinje cell differentiation (GO:0021702)3.69318973
39regulation of excitatory postsynaptic membrane potential (GO:0060079)3.69069095
40gamma-aminobutyric acid transport (GO:0015812)3.65269752
41exploration behavior (GO:0035640)3.63068604
42membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.61537883
43regulation of postsynaptic membrane potential (GO:0060078)3.57580838
44startle response (GO:0001964)3.48261526
45regulation of synaptic transmission, glutamatergic (GO:0051966)3.48232596
46neuron recognition (GO:0008038)3.47423703
47proline transport (GO:0015824)3.46677018
48regulation of long-term neuronal synaptic plasticity (GO:0048169)3.43927001
49neurotransmitter transport (GO:0006836)3.41879719
50regulation of neurotransmitter secretion (GO:0046928)3.41783725
51regulation of neuronal synaptic plasticity (GO:0048168)3.40752062
52transmission of nerve impulse (GO:0019226)3.40650026
53dendritic spine morphogenesis (GO:0060997)3.39964804
54long-term memory (GO:0007616)3.35556154
55positive regulation of membrane potential (GO:0045838)3.35235375
56positive regulation of synaptic transmission, GABAergic (GO:0032230)3.31375984
57cerebellar granule cell differentiation (GO:0021707)3.31049517
58establishment of mitochondrion localization (GO:0051654)3.30837083
59nucleobase catabolic process (GO:0046113)3.29800615
60regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.28004878
61regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.26613797
62negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.26557210
63positive regulation of synapse assembly (GO:0051965)3.24770168
64negative regulation of dendrite morphogenesis (GO:0050774)3.24746518
65membrane depolarization (GO:0051899)3.24663573
66membrane depolarization during action potential (GO:0086010)3.24230927
67response to histamine (GO:0034776)3.22527597
68neurofilament cytoskeleton organization (GO:0060052)3.20091504
69membrane hyperpolarization (GO:0060081)3.19887122
70long-term synaptic potentiation (GO:0060291)3.19555954
71negative regulation of cytosolic calcium ion concentration (GO:0051481)3.19377075
72synapse assembly (GO:0007416)3.18404970
73righting reflex (GO:0060013)3.17810451
74synaptic vesicle endocytosis (GO:0048488)3.16177359
75axonal fasciculation (GO:0007413)3.15457497
76positive regulation of neurotransmitter secretion (GO:0001956)3.13332873
77regulation of neurotransmitter transport (GO:0051588)3.13111290
78epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.12672132
79auditory behavior (GO:0031223)3.12570053
80positive regulation of dendritic spine development (GO:0060999)3.12552688
81regulation of vesicle fusion (GO:0031338)3.10878357
82regulation of neurotransmitter levels (GO:0001505)3.07058461
83positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.04520989
84detection of calcium ion (GO:0005513)3.03055107
85layer formation in cerebral cortex (GO:0021819)3.01806234
86regulation of synaptic plasticity (GO:0048167)3.01774493
87glycosphingolipid biosynthetic process (GO:0006688)3.01735968
88behavioral response to nicotine (GO:0035095)3.01271070
89response to auditory stimulus (GO:0010996)3.00304907
90neuron remodeling (GO:0016322)2.99994050
91cellular potassium ion homeostasis (GO:0030007)2.99734876
92mechanosensory behavior (GO:0007638)2.99335188
93positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.98610685
94regulation of synaptic transmission, GABAergic (GO:0032228)2.98181485
95glycine transport (GO:0015816)2.95182970
96positive regulation of neurotransmitter transport (GO:0051590)2.94589519
97synaptic transmission (GO:0007268)2.94439285
98regulation of respiratory system process (GO:0044065)2.94348897
99establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.94003485
100mitochondrion transport along microtubule (GO:0047497)2.94003485
101regulation of synapse assembly (GO:0051963)2.93309752
102regulation of microtubule-based movement (GO:0060632)2.93296696
103central nervous system myelination (GO:0022010)2.92668873
104axon ensheathment in central nervous system (GO:0032291)2.92668873
105negative regulation of dendrite development (GO:2000171)2.91125909
106cerebral cortex radially oriented cell migration (GO:0021799)2.91078264
107calcium ion-dependent exocytosis (GO:0017156)2.91042885
108regulation of synapse structural plasticity (GO:0051823)2.91004939
109adult walking behavior (GO:0007628)2.90865634
110amino acid import (GO:0043090)2.90746244
111acidic amino acid transport (GO:0015800)2.89788645
112G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.87113636
113central nervous system projection neuron axonogenesis (GO:0021952)2.85155007
114learning (GO:0007612)2.83534810
115regulation of voltage-gated calcium channel activity (GO:1901385)2.79965865
116otic vesicle formation (GO:0030916)2.79894284
117regulation of dendritic spine morphogenesis (GO:0061001)2.79211255
118innervation (GO:0060384)2.77921965
119neurotransmitter uptake (GO:0001504)2.77891059
120positive regulation of synaptic transmission (GO:0050806)2.77398909
121prepulse inhibition (GO:0060134)2.76799909
122regulation of synaptic transmission (GO:0050804)2.75459177
123regulation of synapse maturation (GO:0090128)2.75163027
124response to pheromone (GO:0019236)2.74124677
125L-glutamate transport (GO:0015813)2.73679565
126neuronal ion channel clustering (GO:0045161)2.72891972
127negative regulation of neurotransmitter transport (GO:0051589)2.71344307
128positive regulation of synapse maturation (GO:0090129)2.70731287
129regulation of dendritic spine development (GO:0060998)2.70295100
130neuronal action potential (GO:0019228)2.70257088
131detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.68083423
132positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.67941773
133epithelial cell differentiation involved in kidney development (GO:0035850)2.67195809
134dendrite morphogenesis (GO:0048813)2.66678785

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.38939858
2* GBX2_23144817_ChIP-Seq_PC3_Human4.04617867
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.87203640
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.84942534
5* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.74685731
6* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.43070352
7TAF15_26573619_Chip-Seq_HEK293_Human2.42445997
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.41057009
9* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.41036886
10* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.41036886
11* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.36367946
12* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.32965807
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.30324199
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.28685849
15* EED_16625203_ChIP-ChIP_MESCs_Mouse2.28135631
16* REST_21632747_ChIP-Seq_MESCs_Mouse2.25323001
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.24328826
18* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.15498619
19* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.14330877
20DROSHA_22980978_ChIP-Seq_HELA_Human2.02312162
21CTBP2_25329375_ChIP-Seq_LNCAP_Human2.01178310
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.98543161
23* EZH2_27294783_Chip-Seq_ESCs_Mouse1.98511452
24RNF2_27304074_Chip-Seq_ESCs_Mouse1.97610439
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.97102390
26* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.96666448
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.92936821
28SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.87560627
29* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.86109818
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.84995212
31* SMAD4_21799915_ChIP-Seq_A2780_Human1.81652466
32* P300_19829295_ChIP-Seq_ESCs_Human1.75194369
33TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74565152
34CBX2_27304074_Chip-Seq_ESCs_Mouse1.73544100
35* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.71196529
36SMAD_19615063_ChIP-ChIP_OVARY_Human1.69507884
37AR_21572438_ChIP-Seq_LNCaP_Human1.68283076
38IKZF1_21737484_ChIP-ChIP_HCT116_Human1.64969998
39* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.64528397
40* REST_18959480_ChIP-ChIP_MESCs_Mouse1.63536418
41CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.63362224
42BCAT_22108803_ChIP-Seq_LS180_Human1.55810301
43NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.55433899
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.52753247
45RARB_27405468_Chip-Seq_BRAIN_Mouse1.52121768
46IGF1R_20145208_ChIP-Seq_DFB_Human1.52061321
47EWS_26573619_Chip-Seq_HEK293_Human1.51161679
48RNF2_27304074_Chip-Seq_NSC_Mouse1.47790705
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.47459299
50SALL1_21062744_ChIP-ChIP_HESCs_Human1.46575943
51VDR_22108803_ChIP-Seq_LS180_Human1.43705596
52RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.42045626
53* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.41580146
54PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.41199450
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39828079
56FUS_26573619_Chip-Seq_HEK293_Human1.39340632
57* NANOG_18555785_Chip-Seq_ESCs_Mouse1.39064781
58CDX2_19796622_ChIP-Seq_MESCs_Mouse1.38819166
59* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.38799834
60* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38108289
61* STAT3_23295773_ChIP-Seq_U87_Human1.38082366
62FLI1_27457419_Chip-Seq_LIVER_Mouse1.37427357
63* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.37046964
64MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.35294418
65* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34858648
66AR_25329375_ChIP-Seq_VCAP_Human1.33571782
67AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.31144879
68TP53_16413492_ChIP-PET_HCT116_Human1.29808147
69* E2F1_18555785_Chip-Seq_ESCs_Mouse1.26327168
70CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.26069041
71* TCF4_23295773_ChIP-Seq_U87_Human1.25775143
72* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.25659054
73CBP_20019798_ChIP-Seq_JUKART_Human1.25015030
74IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25015030
75* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24670871
76* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24562342
77CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24535028
78FLI1_21867929_ChIP-Seq_TH2_Mouse1.24224995
79ER_23166858_ChIP-Seq_MCF-7_Human1.23311068
80* SOX2_21211035_ChIP-Seq_LN229_Gbm1.23049953
81* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21485471
82* P53_22387025_ChIP-Seq_ESCs_Mouse1.20810953
83* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20622558
84* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.19967001
85* CMYC_18555785_Chip-Seq_ESCs_Mouse1.19815004
86TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19440562
87P53_22127205_ChIP-Seq_FIBROBLAST_Human1.18874085
88TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.17823241
89* RUNX2_22187159_ChIP-Seq_PCA_Human1.17375693
90TCF4_22108803_ChIP-Seq_LS180_Human1.16664356
91ZNF274_21170338_ChIP-Seq_K562_Hela1.14852707
92* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.13531066
93* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.13471465
94CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.13068681
95ARNT_22903824_ChIP-Seq_MCF-7_Human1.11798103
96RBPJ_22232070_ChIP-Seq_NCS_Mouse1.10615786
97* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09752889
98* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09752889
99NR3C1_23031785_ChIP-Seq_PC12_Mouse1.08727081
100* SOX9_26525672_Chip-Seq_HEART_Mouse1.08641405
101* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.08510764
102MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08364120
103TP53_18474530_ChIP-ChIP_U2OS_Human1.08290923
104* NFE2_27457419_Chip-Seq_LIVER_Mouse1.07263941
105KDM2B_26808549_Chip-Seq_REH_Human1.07258123
106* P300_18555785_Chip-Seq_ESCs_Mouse1.07242745
107AHR_22903824_ChIP-Seq_MCF-7_Human1.06397528
108TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.06288792
109* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06283702
110* STAT3_18555785_Chip-Seq_ESCs_Mouse1.06236265
111KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05831138
112* SOX2_18555785_Chip-Seq_ESCs_Mouse1.05554438
113TAL1_26923725_Chip-Seq_HPCs_Mouse1.05422865
114ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05310221
115* NMYC_18555785_Chip-Seq_ESCs_Mouse1.05126443
116PRDM14_20953172_ChIP-Seq_ESCs_Human1.04346674
117* AR_19668381_ChIP-Seq_PC3_Human1.04278252
118MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02806454
119* RING1B_27294783_Chip-Seq_ESCs_Mouse1.02257897
120* EZH2_27294783_Chip-Seq_NPCs_Mouse0.99649966
121JUN_21703547_ChIP-Seq_K562_Human0.99649651

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.98836740
2MP0004859_abnormal_synaptic_plasticity4.95545535
3MP0003635_abnormal_synaptic_transmissio3.68919077
4MP0009046_muscle_twitch3.52359051
5MP0001968_abnormal_touch/_nociception3.46562922
6MP0009745_abnormal_behavioral_response3.25926011
7MP0004270_analgesia3.16807079
8MP0002064_seizures3.00052710
9MP0002063_abnormal_learning/memory/cond2.88667358
10MP0005423_abnormal_somatic_nervous2.85518379
11MP0001486_abnormal_startle_reflex2.79527812
12MP0002736_abnormal_nociception_after2.79138117
13MP0002734_abnormal_mechanical_nocicepti2.76210897
14MP0002572_abnormal_emotion/affect_behav2.71349934
15MP0002735_abnormal_chemical_nociception2.69349439
16MP0002272_abnormal_nervous_system2.69012919
17MP0001188_hyperpigmentation2.41616665
18MP0001501_abnormal_sleep_pattern2.27068496
19MP0002067_abnormal_sensory_capabilities2.26384993
20MP0001440_abnormal_grooming_behavior2.19742182
21MP0006276_abnormal_autonomic_nervous2.18155037
22MP0002653_abnormal_ependyma_morphology2.17075107
23MP0002733_abnormal_thermal_nociception2.12886822
24MP0001970_abnormal_pain_threshold2.06032311
25MP0005645_abnormal_hypothalamus_physiol1.99069947
26MP0005646_abnormal_pituitary_gland1.94360637
27MP0002184_abnormal_innervation1.92605725
28MP0002557_abnormal_social/conspecific_i1.84251305
29MP0009379_abnormal_foot_pigmentation1.83323027
30MP0002822_catalepsy1.76952411
31MP0005386_behavior/neurological_phenoty1.76948513
32MP0004924_abnormal_behavior1.76948513
33MP0003879_abnormal_hair_cell1.75950527
34MP0004742_abnormal_vestibular_system1.74918439
35MP0001984_abnormal_olfaction1.74150831
36MP0008569_lethality_at_weaning1.73722795
37MP0000778_abnormal_nervous_system1.71961160
38MP0008057_abnormal_DNA_replication1.70401030
39MP0003787_abnormal_imprinting1.66762018
40MP0005187_abnormal_penis_morphology1.63419207
41MP0004142_abnormal_muscle_tone1.60815302
42MP0001529_abnormal_vocalization1.57434322
43MP0009780_abnormal_chondrocyte_physiolo1.55251251
44MP0008877_abnormal_DNA_methylation1.49227662
45MP0001502_abnormal_circadian_rhythm1.48280312
46MP0001905_abnormal_dopamine_level1.42449863
47MP0002876_abnormal_thyroid_physiology1.36273020
48MP0000569_abnormal_digit_pigmentation1.35587256
49MP0002066_abnormal_motor_capabilities/c1.32954190
50MP0000955_abnormal_spinal_cord1.32824113
51MP0004811_abnormal_neuron_physiology1.32659060
52MP0002882_abnormal_neuron_morphology1.31906631
53MP0001986_abnormal_taste_sensitivity1.21952752
54MP0005551_abnormal_eye_electrophysiolog1.20422251
55MP0010386_abnormal_urinary_bladder1.19928766
56MP0001963_abnormal_hearing_physiology1.19589519
57MP0005174_abnormal_tail_pigmentation1.19258044
58MP0003121_genomic_imprinting1.16858392
59MP0003122_maternal_imprinting1.14255993
60MP0004858_abnormal_nervous_system1.10900566
61MP0005409_darkened_coat_color1.10661306
62MP0003633_abnormal_nervous_system1.08676645
63MP0005171_absent_coat_pigmentation1.08024165
64MP0002102_abnormal_ear_morphology1.05247547
65MP0002638_abnormal_pupillary_reflex1.04170021
66MP0004885_abnormal_endolymph1.00460996
67MP0001485_abnormal_pinna_reflex0.98295122
68MP0000647_abnormal_sebaceous_gland0.96855149
69MP0000631_abnormal_neuroendocrine_gland0.95721773
70MP0003631_nervous_system_phenotype0.95709423
71MP0002229_neurodegeneration0.95202641
72MP0002909_abnormal_adrenal_gland0.94195148
73MP0003283_abnormal_digestive_organ0.93694587
74MP0002152_abnormal_brain_morphology0.92614474
75MP0003329_amyloid_beta_deposits0.92131588
76MP0008872_abnormal_physiological_respon0.92116418
77MP0004145_abnormal_muscle_electrophysio0.91794731
78MP0002752_abnormal_somatic_nervous0.90460346
79MP0000026_abnormal_inner_ear0.88823782
80MP0003183_abnormal_peptide_metabolism0.88681940
81MP0001664_abnormal_digestion0.85615772
82MP0003119_abnormal_digestive_system0.84591984
83MP0002069_abnormal_eating/drinking_beha0.81653146
84MP0008874_decreased_physiological_sensi0.78844968
85MP0005379_endocrine/exocrine_gland_phen0.78020302
86MP0003890_abnormal_embryonic-extraembry0.77326852
87MP0004133_heterotaxia0.75985970
88MP0006292_abnormal_olfactory_placode0.74852967
89MP0000920_abnormal_myelination0.74771225
90MP0003861_abnormal_nervous_system0.74366467
91MP0002938_white_spotting0.72630428
92MP0000015_abnormal_ear_pigmentation0.72345848
93MP0004085_abnormal_heartbeat0.72335377
94MP0004147_increased_porphyrin_level0.71546928
95MP0000383_abnormal_hair_follicle0.71382859
96MP0005499_abnormal_olfactory_system0.71366851
97MP0005394_taste/olfaction_phenotype0.71366851
98MP0001177_atelectasis0.71256216
99MP0005535_abnormal_body_temperature0.70657422
100MP0008004_abnormal_stomach_pH0.68384198
101MP0003137_abnormal_impulse_conducting0.68106597
102MP0003632_abnormal_nervous_system0.65695861
103MP0002282_abnormal_trachea_morphology0.65362975
104MP0003136_yellow_coat_color0.64567568
105MP0004484_altered_response_of0.63533440
106MP0000538_abnormal_urinary_bladder0.63133733
107MP0003937_abnormal_limbs/digits/tail_de0.62573743
108MP0000639_abnormal_adrenal_gland0.62501905
109MP0003634_abnormal_glial_cell0.62063957
110MP0006072_abnormal_retinal_apoptosis0.62007513
111MP0002234_abnormal_pharynx_morphology0.60002335
112MP0003690_abnormal_glial_cell0.59436492
113MP0002837_dystrophic_cardiac_calcinosis0.58840871
114MP0008260_abnormal_autophagy0.58169926
115MP0002751_abnormal_autonomic_nervous0.58006537
116MP0000751_myopathy0.57991417
117MP0005253_abnormal_eye_physiology0.57564647
118MP0002163_abnormal_gland_morphology0.54729393
119MP0001943_abnormal_respiration0.53231438
120MP0004215_abnormal_myocardial_fiber0.53011155
121MP0001299_abnormal_eye_distance/0.51772106
122MP0005410_abnormal_fertilization0.50172988

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.13537280
2Febrile seizures (HP:0002373)6.13458943
3Focal seizures (HP:0007359)5.59032242
4Epileptic encephalopathy (HP:0200134)5.19856622
5Atonic seizures (HP:0010819)5.09986234
6Myokymia (HP:0002411)5.00219901
7Progressive cerebellar ataxia (HP:0002073)4.70998179
8Absence seizures (HP:0002121)4.18838621
9Visual hallucinations (HP:0002367)4.13267223
10Generalized tonic-clonic seizures (HP:0002069)4.03681583
11Broad-based gait (HP:0002136)3.93184785
12Dialeptic seizures (HP:0011146)3.90153589
13Gaze-evoked nystagmus (HP:0000640)3.84039346
14Hyperventilation (HP:0002883)3.71571709
15True hermaphroditism (HP:0010459)3.60632704
16Pancreatic cysts (HP:0001737)3.48882677
17Action tremor (HP:0002345)3.38206525
18Pancreatic fibrosis (HP:0100732)3.27634020
19Absent/shortened dynein arms (HP:0200106)3.22153388
20Dynein arm defect of respiratory motile cilia (HP:0012255)3.22153388
21Volvulus (HP:0002580)2.98510927
22Abnormality of midbrain morphology (HP:0002418)2.96821350
23Molar tooth sign on MRI (HP:0002419)2.96821350
24Truncal ataxia (HP:0002078)2.91299033
25Dysdiadochokinesis (HP:0002075)2.88238651
26Nephronophthisis (HP:0000090)2.84148496
27Poor eye contact (HP:0000817)2.83173503
28Absent speech (HP:0001344)2.79267211
29Drooling (HP:0002307)2.74867248
30Excessive salivation (HP:0003781)2.74867248
31Dysmetria (HP:0001310)2.67526997
32Scanning speech (HP:0002168)2.67188888
33Limb dystonia (HP:0002451)2.66036809
34Protruding tongue (HP:0010808)2.64150929
35Fetal akinesia sequence (HP:0001989)2.63091588
36Progressive inability to walk (HP:0002505)2.58870803
37Abnormal ciliary motility (HP:0012262)2.56545540
38Inability to walk (HP:0002540)2.55427721
39Impaired vibration sensation in the lower limbs (HP:0002166)2.54810229
40Abnormal eating behavior (HP:0100738)2.53037207
41Urinary bladder sphincter dysfunction (HP:0002839)2.51189915
42Amblyopia (HP:0000646)2.46648647
43Blue irides (HP:0000635)2.46611826
44Abnormal hair whorl (HP:0010721)2.45114653
45Ankle clonus (HP:0011448)2.44572516
46Gait imbalance (HP:0002141)2.40610621
47Genetic anticipation (HP:0003743)2.40423655
48Cystic liver disease (HP:0006706)2.39825930
49Hemiparesis (HP:0001269)2.38834703
50Impaired smooth pursuit (HP:0007772)2.36132033
51Supranuclear gaze palsy (HP:0000605)2.34772283
52Abnormal social behavior (HP:0012433)2.33086560
53Impaired social interactions (HP:0000735)2.33086560
54Abnormality of the astrocytes (HP:0100707)2.31148820
55Astrocytoma (HP:0009592)2.31148820
56Anxiety (HP:0000739)2.29525539
57Abnormality of binocular vision (HP:0011514)2.27963959
58Diplopia (HP:0000651)2.27963959
59Medial flaring of the eyebrow (HP:0010747)2.26408849
60Depression (HP:0000716)2.23140891
61Epileptiform EEG discharges (HP:0011182)2.19292686
62Polyphagia (HP:0002591)2.18096272
63Facial hemangioma (HP:0000329)2.16583265
64Abnormality of the renal medulla (HP:0100957)2.15502246
65Postural instability (HP:0002172)2.15389843
66Abnormal respiratory motile cilium physiology (HP:0012261)2.14986428
67Abnormality of ocular smooth pursuit (HP:0000617)2.14320302
68Esotropia (HP:0000565)2.12958954
69Generalized hypopigmentation of hair (HP:0011358)2.11523256
70Abnormality of the corticospinal tract (HP:0002492)2.11361412
71Mutism (HP:0002300)2.10746181
72Aplasia/Hypoplasia of the tongue (HP:0010295)2.09241072
73Congenital primary aphakia (HP:0007707)2.09209585
74Abnormality of salivation (HP:0100755)2.09133609
75Renal cortical cysts (HP:0000803)2.08188507
76Abnormal respiratory epithelium morphology (HP:0012253)2.07068740
77Abnormal respiratory motile cilium morphology (HP:0005938)2.07068740
78Status epilepticus (HP:0002133)2.05044844
79Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.04487006
80EEG with generalized epileptiform discharges (HP:0011198)2.03401563
81Fair hair (HP:0002286)2.02166867
82Megalencephaly (HP:0001355)2.02051840
83Spastic gait (HP:0002064)2.01526569
84Specific learning disability (HP:0001328)2.01139516
85Nephrogenic diabetes insipidus (HP:0009806)1.99188492
86Choroideremia (HP:0001139)1.99006283
87Genital tract atresia (HP:0001827)1.98359452
88Papillary thyroid carcinoma (HP:0002895)1.98046714
89Abnormality of the renal cortex (HP:0011035)1.97569325
90Poor coordination (HP:0002370)1.97392924
91Intention tremor (HP:0002080)1.96431585
92Colon cancer (HP:0003003)1.95771690
93Papilledema (HP:0001085)1.95199479
94Pheochromocytoma (HP:0002666)1.94024094
95Optic nerve hypoplasia (HP:0000609)1.93471504
96Vaginal atresia (HP:0000148)1.92293830
97Abolished electroretinogram (ERG) (HP:0000550)1.91322462
98Impaired vibratory sensation (HP:0002495)1.90511318
99Insidious onset (HP:0003587)1.89044586
100Termporal pattern (HP:0011008)1.89044586
101Agitation (HP:0000713)1.88911663
102Stereotypic behavior (HP:0000733)1.88839817
103Hepatoblastoma (HP:0002884)1.88476759
104Akinesia (HP:0002304)1.87709381
105Abnormality of calcium-phosphate metabolism (HP:0100530)1.86738661
106Hemiplegia (HP:0002301)1.85940540
107Glioma (HP:0009733)1.85862285
108Medulloblastoma (HP:0002885)1.85742739
109Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.85217968
110Chronic hepatic failure (HP:0100626)1.84950139
111Bradykinesia (HP:0002067)1.84768385
112Hypsarrhythmia (HP:0002521)1.84434107
113Intestinal atresia (HP:0011100)1.83980331
114Sclerocornea (HP:0000647)1.83508288
115Spastic tetraplegia (HP:0002510)1.83441595
116Male pseudohermaphroditism (HP:0000037)1.82520862
117Anencephaly (HP:0002323)1.81491854
118Exotropia (HP:0000577)1.79381093
119Methylmalonic acidemia (HP:0002912)1.78511379
120Urinary urgency (HP:0000012)1.78435081
121Widely spaced teeth (HP:0000687)1.77300965
122Retinal dysplasia (HP:0007973)1.77295848
123Congenital hepatic fibrosis (HP:0002612)1.76930249
124Lower limb amyotrophy (HP:0007210)1.75934212
125Ulnar claw (HP:0001178)1.75631818
126Abnormality of the labia minora (HP:0012880)1.74652000
127Generalized myoclonic seizures (HP:0002123)1.74472120
128Narrow forehead (HP:0000341)1.74356932
129Bony spicule pigmentary retinopathy (HP:0007737)1.74133936
130Rhinitis (HP:0012384)1.73552437
131Degeneration of the lateral corticospinal tracts (HP:0002314)1.73447732
132Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.73447732
133Gait ataxia (HP:0002066)1.73317806
134Absent eyebrow (HP:0002223)1.73117689
135Hyperthyroidism (HP:0000836)1.72326566
136Failure to thrive in infancy (HP:0001531)1.71846103
137Dysmetric saccades (HP:0000641)1.69979718
138Incomplete penetrance (HP:0003829)1.69659260
139Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.69210868

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK16.53238023
2CASK4.46231140
3NTRK34.07884064
4EPHA43.37036637
5MAP2K73.11845686
6MAP3K42.90580715
7MAP3K92.72987310
8DAPK22.49281157
9MARK12.45252058
10MAP3K122.42626957
11TNIK2.19415778
12RIPK42.07791778
13NTRK21.92991172
14NEK21.85700620
15MINK11.82378832
16SIK21.80240153
17MAP2K41.76561792
18PRPF4B1.76206525
19MAPK131.72411326
20PLK21.65048416
21CDK191.63284893
22GRK51.59283782
23PAK61.57981832
24OXSR11.39150441
25PNCK1.37112705
26NTRK11.35617807
27SIK31.35233330
28DAPK11.31416295
29CDK51.29993091
30CSNK1G31.23302696
31SGK21.22246763
32MAP4K21.21969930
33AKT31.21125190
34SGK2231.20726487
35SGK4941.20726487
36NUAK11.18135323
37BMPR21.15971477
38CAMKK21.15486448
39CSNK1G11.15373921
40CCNB11.15070377
41MAP3K131.14401982
42CSNK1A1L1.14281479
43PRKCG1.13819529
44TRIM281.09419341
45CAMK2A1.08553015
46UHMK11.05226994
47MUSK1.02918409
48PLK40.98315117
49KSR10.96666281
50FES0.95544172
51DYRK20.93411323
52CAMKK10.93029111
53TNK20.92398214
54STK380.88873216
55ADRBK20.88418088
56INSRR0.86355096
57CAMK10.86354600
58CAMK2B0.84296919
59KSR20.83622202
60NEK60.82851584
61SGK10.82303009
62TAF10.81622426
63ROCK20.80158413
64STK110.79731216
65PRKCE0.79263934
66PKN10.78247889
67WNK10.77502058
68SGK30.74253361
69PINK10.74012664
70ARAF0.71069021
71GRK70.69732233
72PHKG20.69573234
73PHKG10.69573234
74WNK30.68892483
75MAP3K20.67984573
76DYRK1A0.65032427
77STK390.64603812
78BMPR1B0.64589356
79CDK180.64190555
80CDC70.63357485
81MAPKAPK50.62889198
82ACVR1B0.62785307
83CSNK1A10.61297717
84GRK10.60787197
85CAMK2D0.60497803
86CDK150.60425045
87YES10.59433545
88BCR0.59160739
89CDK30.58518445
90CAMK1G0.58364695
91CDK140.57907613
92CSNK1G20.56767230
93FGR0.56601540
94MARK20.54822756
95CSNK1D0.52465911
96RET0.51950237
97PTK2B0.50835629
98CDK11A0.50081965
99CSNK1E0.49538451
100CAMK2G0.49013914
101PRKD30.48910825
102FGFR20.46876490
103TYRO30.46749406
104PRKG10.45937283
105PRKACB0.45918704
106PRKCH0.45495975
107MKNK20.44745111
108CDC42BPA0.44713373
109PRKCZ0.44694538
110MAP3K60.44518186
111ERBB30.43559477
112WNK40.43335966
113CAMK40.42249037
114ADRBK10.41554607
115PAK30.41305119
116BRAF0.41251350
117MAPK120.40970886
118PRKACA0.40173834
119FRK0.39859440
120PDK10.39245504
121MAPK70.38944706
122LATS20.37708456
123RPS6KA30.37201911
124MAPK100.36642748
125FYN0.36611089
126PRKCB0.36476697
127MAPK80.34576369
128RPS6KB10.32365889
129TAOK30.30199186
130PRKCA0.29805304
131GSK3B0.27394841

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.41198497
2Synaptic vesicle cycle_Homo sapiens_hsa047213.36656506
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.89665908
4Morphine addiction_Homo sapiens_hsa050322.75348906
5GABAergic synapse_Homo sapiens_hsa047272.68092915
6Glutamatergic synapse_Homo sapiens_hsa047242.64048241
7Olfactory transduction_Homo sapiens_hsa047402.57988280
8Circadian entrainment_Homo sapiens_hsa047132.53070477
9Taste transduction_Homo sapiens_hsa047422.43494672
10Amphetamine addiction_Homo sapiens_hsa050312.23856323
11Long-term potentiation_Homo sapiens_hsa047202.23727962
12Salivary secretion_Homo sapiens_hsa049702.07784579
13Serotonergic synapse_Homo sapiens_hsa047262.04152090
14Collecting duct acid secretion_Homo sapiens_hsa049662.00187896
15Insulin secretion_Homo sapiens_hsa049111.97295139
16Dopaminergic synapse_Homo sapiens_hsa047281.95541316
17Long-term depression_Homo sapiens_hsa047301.90993295
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.80980778
19Cholinergic synapse_Homo sapiens_hsa047251.75796007
20Calcium signaling pathway_Homo sapiens_hsa040201.68539371
21Gastric acid secretion_Homo sapiens_hsa049711.62339317
22Renin secretion_Homo sapiens_hsa049241.61924021
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.60124025
24Nitrogen metabolism_Homo sapiens_hsa009101.59194129
25Cocaine addiction_Homo sapiens_hsa050301.57972671
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.55802069
27Oxytocin signaling pathway_Homo sapiens_hsa049211.46468507
28Phototransduction_Homo sapiens_hsa047441.39668173
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.35661348
30Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.32385986
31GnRH signaling pathway_Homo sapiens_hsa049121.30535386
32Phosphatidylinositol signaling system_Homo sapiens_hsa040701.29102458
33cAMP signaling pathway_Homo sapiens_hsa040241.21002342
34Type II diabetes mellitus_Homo sapiens_hsa049301.20871784
35Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.18472811
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.17142408
37Axon guidance_Homo sapiens_hsa043601.16344729
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.14588086
39Gap junction_Homo sapiens_hsa045401.07750551
40Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.07095980
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.06106693
42Butanoate metabolism_Homo sapiens_hsa006501.04009559
43Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.03111996
44Vibrio cholerae infection_Homo sapiens_hsa051101.02308823
45Cardiac muscle contraction_Homo sapiens_hsa042600.98381681
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.95608248
47ErbB signaling pathway_Homo sapiens_hsa040120.93759433
48cGMP-PKG signaling pathway_Homo sapiens_hsa040220.92434949
49Propanoate metabolism_Homo sapiens_hsa006400.92386077
50Dorso-ventral axis formation_Homo sapiens_hsa043200.90145950
51Vascular smooth muscle contraction_Homo sapiens_hsa042700.89428911
52Estrogen signaling pathway_Homo sapiens_hsa049150.87376755
53Melanogenesis_Homo sapiens_hsa049160.86057248
54Pancreatic secretion_Homo sapiens_hsa049720.83886174
55Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.81951625
56Vitamin B6 metabolism_Homo sapiens_hsa007500.80782697
57Ovarian steroidogenesis_Homo sapiens_hsa049130.79411458
58Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.73843813
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.73044809
60MAPK signaling pathway_Homo sapiens_hsa040100.72306686
61Rheumatoid arthritis_Homo sapiens_hsa053230.72239681
62alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.71941424
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71584484
64Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.71370260
65Inositol phosphate metabolism_Homo sapiens_hsa005620.69832569
66Glioma_Homo sapiens_hsa052140.68898976
67Bile secretion_Homo sapiens_hsa049760.68641300
68Type I diabetes mellitus_Homo sapiens_hsa049400.68139436
69Choline metabolism in cancer_Homo sapiens_hsa052310.67935478
70SNARE interactions in vesicular transport_Homo sapiens_hsa041300.67920668
71Oxidative phosphorylation_Homo sapiens_hsa001900.66872645
72Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.65195270
73Circadian rhythm_Homo sapiens_hsa047100.64366696
74Ras signaling pathway_Homo sapiens_hsa040140.64017820
75Dilated cardiomyopathy_Homo sapiens_hsa054140.63322122
76Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62893447
77Thyroid hormone synthesis_Homo sapiens_hsa049180.61679836
78Alzheimers disease_Homo sapiens_hsa050100.59549010
79African trypanosomiasis_Homo sapiens_hsa051430.56888701
80Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55700453
81beta-Alanine metabolism_Homo sapiens_hsa004100.55527536
82Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55301839
83Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54175722
84Ether lipid metabolism_Homo sapiens_hsa005650.53493370
85Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52692902
86Primary bile acid biosynthesis_Homo sapiens_hsa001200.52509706
87Histidine metabolism_Homo sapiens_hsa003400.51248451
88Hedgehog signaling pathway_Homo sapiens_hsa043400.51163532
89Steroid hormone biosynthesis_Homo sapiens_hsa001400.50272378
90Fanconi anemia pathway_Homo sapiens_hsa034600.49342267
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.49273814
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48824668
93Oocyte meiosis_Homo sapiens_hsa041140.47901562
94Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.46677414
95Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46254288
96Wnt signaling pathway_Homo sapiens_hsa043100.44524625
97Rap1 signaling pathway_Homo sapiens_hsa040150.44189209
98Protein export_Homo sapiens_hsa030600.43862085
99Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43780807
100Hippo signaling pathway_Homo sapiens_hsa043900.43540937
101Alcoholism_Homo sapiens_hsa050340.43517228
102ABC transporters_Homo sapiens_hsa020100.42939835
103Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.42325899
104Chemokine signaling pathway_Homo sapiens_hsa040620.40234340
105Phagosome_Homo sapiens_hsa041450.39043215
106Linoleic acid metabolism_Homo sapiens_hsa005910.38269657
107Basal cell carcinoma_Homo sapiens_hsa052170.34585254
108Glycerolipid metabolism_Homo sapiens_hsa005610.33795131
109Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.32946803
110Mineral absorption_Homo sapiens_hsa049780.32868487
111Autoimmune thyroid disease_Homo sapiens_hsa053200.32246953
112Sphingolipid metabolism_Homo sapiens_hsa006000.32190360
113Tryptophan metabolism_Homo sapiens_hsa003800.31442484
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.31281438
115Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31074054
116Melanoma_Homo sapiens_hsa052180.30550384
117Basal transcription factors_Homo sapiens_hsa030220.29148812
118Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.28288418
119Parkinsons disease_Homo sapiens_hsa050120.28257454
120Glucagon signaling pathway_Homo sapiens_hsa049220.27796487
121Neurotrophin signaling pathway_Homo sapiens_hsa047220.26171465
122Huntingtons disease_Homo sapiens_hsa050160.23672615
123Regulation of autophagy_Homo sapiens_hsa041400.23012196
124Endocytosis_Homo sapiens_hsa041440.22628390
125Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.22617027
126Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.21952700
127Thyroid hormone signaling pathway_Homo sapiens_hsa049190.21025398

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