DPP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is a member of the M49 family of metallopeptidases. This cytoplasmic protein binds a single zinc ion with its zinc-binding motif (HELLGH) and has post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Increased activity of this protein is associated with endometrial and ovarian cancers. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)5.61348526
2Golgi transport vesicle coating (GO:0048200)5.61348526
3proline biosynthetic process (GO:0006561)4.92580450
4protein maturation by protein folding (GO:0022417)4.41565412
5peptidyl-arginine omega-N-methylation (GO:0035247)4.29420952
6negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.22541102
7regulation of translational fidelity (GO:0006450)4.12439813
8protein retention in ER lumen (GO:0006621)4.09265478
9maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.98844002
10pentose-phosphate shunt (GO:0006098)3.98385382
11histone arginine methylation (GO:0034969)3.86952535
12establishment of integrated proviral latency (GO:0075713)3.73051732
13DNA unwinding involved in DNA replication (GO:0006268)3.68425163
14NADPH regeneration (GO:0006740)3.67204597
15retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.65802492
16regulation of mitochondrial translation (GO:0070129)3.59457445
17mitotic chromosome condensation (GO:0007076)3.54780642
18glucose catabolic process (GO:0006007)3.52202436
19regulation of mammary gland epithelial cell proliferation (GO:0033599)3.52032672
20negative regulation of cell size (GO:0045792)3.49822731
21spliceosomal tri-snRNP complex assembly (GO:0000244)3.44624375
22peptidyl-arginine N-methylation (GO:0035246)3.42977618
23peptidyl-arginine methylation (GO:0018216)3.42977618
24establishment of viral latency (GO:0019043)3.34573896
25pentose metabolic process (GO:0019321)3.33837965
26ribosomal small subunit biogenesis (GO:0042274)3.28863146
27DNA strand elongation involved in DNA replication (GO:0006271)3.24091409
28DNA strand elongation (GO:0022616)3.22378686
29proline metabolic process (GO:0006560)3.19795709
30mitotic nuclear envelope reassembly (GO:0007084)3.16499474
31nuclear envelope reassembly (GO:0031468)3.16499474
32GDP-mannose metabolic process (GO:0019673)3.13751172
33nucleobase-containing small molecule interconversion (GO:0015949)3.13639069
34glucose 6-phosphate metabolic process (GO:0051156)3.07513848
35formation of translation preinitiation complex (GO:0001731)3.06613710
36maturation of SSU-rRNA (GO:0030490)2.89718336
37biotin metabolic process (GO:0006768)2.89406320
38positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.84622079
39negative regulation of DNA-templated transcription, elongation (GO:0032785)2.84483963
40positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.83547318
41rRNA transcription (GO:0009303)2.81884508
42telomere maintenance via semi-conservative replication (GO:0032201)2.80826284
43nucleosome disassembly (GO:0006337)2.80556550
44protein-DNA complex disassembly (GO:0032986)2.80556550
45regulation of translational termination (GO:0006449)2.79137532
46pinocytosis (GO:0006907)2.76502675
47positive regulation of Cdc42 GTPase activity (GO:0043089)2.74094825
48heterochromatin organization (GO:0070828)2.73921239
49protein localization to endosome (GO:0036010)2.73428927
50tRNA aminoacylation for protein translation (GO:0006418)2.66877805
51L-serine metabolic process (GO:0006563)2.65349608
52protein localization to chromosome, centromeric region (GO:0071459)2.64012688
53regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.61229542
54protein complex localization (GO:0031503)2.60958445
55folic acid-containing compound biosynthetic process (GO:0009396)2.59882869
56mitochondrial fusion (GO:0008053)2.54167772
57amino acid activation (GO:0043038)2.51318385
58tRNA aminoacylation (GO:0043039)2.51318385
59apoptotic process involved in morphogenesis (GO:0060561)2.50577938
60ribonucleoprotein complex biogenesis (GO:0022613)2.50061478
61amyloid precursor protein catabolic process (GO:0042987)2.50035112
62negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.49904632
63barbed-end actin filament capping (GO:0051016)2.47223661
64pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.46746491
65hemidesmosome assembly (GO:0031581)2.45731236
66positive regulation of keratinocyte differentiation (GO:0045618)2.45601122
67ribosome biogenesis (GO:0042254)2.44860792
68pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.44672226
69positive regulation of receptor biosynthetic process (GO:0010870)2.44528334
70negative regulation of ligase activity (GO:0051352)2.44291025
71negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.44291025
72protein insertion into membrane (GO:0051205)2.44219892
73pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.44038501
74endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.43950525
75DNA replication initiation (GO:0006270)2.42984175
76negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.42469004
77epithelial cell-cell adhesion (GO:0090136)2.41475613
78positive regulation of nuclease activity (GO:0032075)2.40413960
79activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.40188440
80negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.38200035
81base-excision repair (GO:0006284)2.37550333
82UTP biosynthetic process (GO:0006228)2.36707585
83tricarboxylic acid metabolic process (GO:0072350)2.36554697
84snRNA metabolic process (GO:0016073)2.35957433
85viral mRNA export from host cell nucleus (GO:0046784)2.35792960
86epithelial cell differentiation involved in prostate gland development (GO:0060742)2.35327579
87adherens junction assembly (GO:0034333)2.33711771
88UV protection (GO:0009650)2.31886120
89deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.31596837
90maternal placenta development (GO:0001893)2.31175387
91regulation of glucose import in response to insulin stimulus (GO:2001273)2.30327101
92planar cell polarity pathway involved in neural tube closure (GO:0090179)2.30021898
93pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.29352533
94negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.29014770
95pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.28554147
96ribosomal small subunit assembly (GO:0000028)2.28284263
97L-alpha-amino acid transmembrane transport (GO:1902475)2.27697598
98anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.27501428
99endoplasmic reticulum unfolded protein response (GO:0030968)2.26692897
100nuclear pore complex assembly (GO:0051292)2.26358375

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human3.93733919
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.50716535
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.30425839
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.01062070
5MYC_18555785_ChIP-Seq_MESCs_Mouse2.88157449
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.75152394
7MYC_18358816_ChIP-ChIP_MESCs_Mouse2.28749700
8MYC_22102868_ChIP-Seq_BL_Human2.17466179
9ZNF263_19887448_ChIP-Seq_K562_Human2.17346221
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.16353677
11MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.14648979
12* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.12173680
13DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.05401927
14* CCND1_20090754_ChIP-ChIP_RETINA_Mouse2.00152933
15FOXM1_23109430_ChIP-Seq_U2OS_Human1.99766694
16TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.97741917
17VDR_21846776_ChIP-Seq_THP-1_Human1.96366355
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.96035975
19MYC_19079543_ChIP-ChIP_MESCs_Mouse1.95891113
20* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.95833369
21XRN2_22483619_ChIP-Seq_HELA_Human1.94305050
22NELFA_20434984_ChIP-Seq_ESCs_Mouse1.89855454
23* ELK3_25401928_ChIP-Seq_HUVEC_Human1.79200314
24LXR_22292898_ChIP-Seq_THP-1_Human1.78293302
25THAP11_20581084_ChIP-Seq_MESCs_Mouse1.77587246
26NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.77051688
27ZFX_18555785_ChIP-Seq_MESCs_Mouse1.74195866
28RACK7_27058665_Chip-Seq_MCF-7_Human1.73648768
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.65572811
30ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.59882769
31ETS1_20019798_ChIP-Seq_JURKAT_Human1.59229078
32E2F1_18555785_ChIP-Seq_MESCs_Mouse1.58295763
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.57902034
34CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.54629658
35RARG_19884340_ChIP-ChIP_MEFs_Mouse1.53520242
36* GABP_19822575_ChIP-Seq_HepG2_Human1.51732679
37CREB1_15753290_ChIP-ChIP_HEK293T_Human1.50729526
38DCP1A_22483619_ChIP-Seq_HELA_Human1.49047439
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.47729526
40POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.46461056
41KLF4_18555785_ChIP-Seq_MESCs_Mouse1.44258104
42* TET1_21451524_ChIP-Seq_MESCs_Mouse1.44099202
43KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.43173110
44NANOG_18555785_ChIP-Seq_MESCs_Mouse1.42080096
45KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.40520082
46MYCN_18555785_ChIP-Seq_MESCs_Mouse1.37165861
47ESR1_15608294_ChIP-ChIP_MCF-7_Human1.35459845
48YY1_21170310_ChIP-Seq_MESCs_Mouse1.34401325
49SRY_22984422_ChIP-ChIP_TESTIS_Rat1.32287187
50TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.30646183
51CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.30433518
52NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.29995190
53* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.28879274
54STAT3_1855785_ChIP-Seq_MESCs_Mouse1.28779798
55HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.28766961
56KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.27810427
57* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.26527497
58AR_21909140_ChIP-Seq_LNCAP_Human1.24744798
59ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.24704005
60* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23950857
61PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.23605585
62ATF3_27146783_Chip-Seq_COLON_Human1.23124866
63* KDM5A_27292631_Chip-Seq_BREAST_Human1.22237197
64CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.21826066
65* P68_20966046_ChIP-Seq_HELA_Human1.17861934
66ERG_20887958_ChIP-Seq_HPC-7_Mouse1.17103273
67TTF2_22483619_ChIP-Seq_HELA_Human1.16585727
68E2F4_17652178_ChIP-ChIP_JURKAT_Human1.15801678
69* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.14667046
70DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.13873321
71E2F1_21310950_ChIP-Seq_MCF-7_Human1.12437176
72* SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.11744432
73MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.11033131
74CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.10750838
75SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.08833606
76HIF1A_21447827_ChIP-Seq_MCF-7_Human1.06981548
77SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.06149994
78CLOCK_20551151_ChIP-Seq_293T_Human1.05651991
79CTCF_18555785_ChIP-Seq_MESCs_Mouse1.04737583
80TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.04315947
81TP53_22127205_ChIP-Seq_IMR90_Human1.04228929
82NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.03520012
83CIITA_25753668_ChIP-Seq_RAJI_Human1.03305395
84KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.02438462
85TFEB_21752829_ChIP-Seq_HELA_Human1.02153033
86ELF1_20517297_ChIP-Seq_JURKAT_Human1.01158392
87ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.00673112
88UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.00668963
89GABP_17652178_ChIP-ChIP_JURKAT_Human0.99894401
90ZFP281_18757296_ChIP-ChIP_E14_Mouse0.99588679
91FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.99277282
92TBX5_21415370_ChIP-Seq_HL-1_Mouse0.98309199
93TCF7_22412390_ChIP-Seq_EML_Mouse0.98263435
94ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.97717269
95TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97413959
96SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.96552540
97* SA1_27219007_Chip-Seq_ERYTHROID_Human0.96512603
98ESR2_21235772_ChIP-Seq_MCF-7_Human0.95332172
99TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.94927998
100FOXP1_21924763_ChIP-Seq_HESCs_Human0.94567163

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle3.89285405
2MP0005451_abnormal_body_composition3.74085923
3MP0003705_abnormal_hypodermis_morpholog3.13995738
4MP0003693_abnormal_embryo_hatching3.11870554
5MP0005058_abnormal_lysosome_morphology2.81191949
6MP0000537_abnormal_urethra_morphology2.73500203
7MP0001849_ear_inflammation2.68039952
8MP0004185_abnormal_adipocyte_glucose2.62979120
9MP0003111_abnormal_nucleus_morphology2.62638174
10MP0004957_abnormal_blastocyst_morpholog2.39559008
11MP0008260_abnormal_autophagy2.23197306
12MP0002796_impaired_skin_barrier2.22274090
13MP0003566_abnormal_cell_adhesion2.21102816
14MP0002877_abnormal_melanocyte_morpholog2.20852729
15MP0005257_abnormal_intraocular_pressure2.13654699
16MP0005501_abnormal_skin_physiology2.13640379
17MP0004233_abnormal_muscle_weight2.07311927
18MP0009840_abnormal_foam_cell2.03975871
19MP0001730_embryonic_growth_arrest1.97606559
20MP0008932_abnormal_embryonic_tissue1.87100515
21MP0010094_abnormal_chromosome_stability1.86742661
22MP0003077_abnormal_cell_cycle1.85634150
23MP0004264_abnormal_extraembryonic_tissu1.85372705
24MP0003123_paternal_imprinting1.70374828
25MP0001727_abnormal_embryo_implantation1.69921280
26MP0005076_abnormal_cell_differentiation1.61363722
27MP0010030_abnormal_orbit_morphology1.61269206
28MP0000490_abnormal_crypts_of1.60204435
29MP0002089_abnormal_postnatal_growth/wei1.59759109
30MP0002254_reproductive_system_inflammat1.59486672
31MP0003941_abnormal_skin_development1.56797063
32MP0003453_abnormal_keratinocyte_physiol1.55717709
33MP0010352_gastrointestinal_tract_polyps1.55352200
34MP0008007_abnormal_cellular_replicative1.45214985
35MP0004858_abnormal_nervous_system1.40549240
36MP0003191_abnormal_cellular_cholesterol1.39710773
37MP0002080_prenatal_lethality1.38169350
38MP0001216_abnormal_epidermal_layer1.36004238
39MP0000350_abnormal_cell_proliferation1.35198226
40MP0009672_abnormal_birth_weight1.33270804
41MP0000678_abnormal_parathyroid_gland1.28538203
42MP0001661_extended_life_span1.28508648
43MP0002060_abnormal_skin_morphology1.27586423
44MP0000858_altered_metastatic_potential1.27241660
45MP0004272_abnormal_basement_membrane1.26972210
46MP0009053_abnormal_anal_canal1.25050538
47MP0002098_abnormal_vibrissa_morphology1.23197257
48MP0003315_abnormal_perineum_morphology1.19649270
49MP0001672_abnormal_embryogenesis/_devel1.18400804
50MP0005380_embryogenesis_phenotype1.18400804
51MP0000313_abnormal_cell_death1.14499076
52MP0000467_abnormal_esophagus_morphology1.12393479
53MP0005666_abnormal_adipose_tissue1.11762567
54MP0003806_abnormal_nucleotide_metabolis1.11188536
55MP0001881_abnormal_mammary_gland1.07108014
56MP0001697_abnormal_embryo_size1.05160585
57MP0003984_embryonic_growth_retardation1.04838786
58MP0008789_abnormal_olfactory_epithelium1.04119989
59MP0002085_abnormal_embryonic_tissue1.01066568
60MP0001853_heart_inflammation1.01065714
61MP0009278_abnormal_bone_marrow0.99647020
62MP0000627_abnormal_mammary_gland0.98324998
63MP0008438_abnormal_cutaneous_collagen0.98224257
64MP0002088_abnormal_embryonic_growth/wei0.97612116
65MP0000377_abnormal_hair_follicle0.97524288
66MP0001348_abnormal_lacrimal_gland0.97112931
67MP0005408_hypopigmentation0.95069363
68MP0002086_abnormal_extraembryonic_tissu0.94052289
69MP0009384_cardiac_valve_regurgitation0.94032461
70MP0000762_abnormal_tongue_morphology0.93316062
71MP0005394_taste/olfaction_phenotype0.92182249
72MP0005499_abnormal_olfactory_system0.92182249
73MP0000358_abnormal_cell_content/0.92039691
74MP0000462_abnormal_digestive_system0.91652313
75MP0009931_abnormal_skin_appearance0.90502751
76MP0003786_premature_aging0.90206765
77MP0004782_abnormal_surfactant_physiolog0.87637312
78MP0005621_abnormal_cell_physiology0.87349404
79MP0010771_integument_phenotype0.85390845
80MP0000003_abnormal_adipose_tissue0.85196583
81MP0000579_abnormal_nail_morphology0.84962995
82MP0005384_cellular_phenotype0.83674251
83MP0005375_adipose_tissue_phenotype0.83293821
84MP0000477_abnormal_intestine_morphology0.82869316
85MP0002111_abnormal_tail_morphology0.82077780
86MP0005023_abnormal_wound_healing0.82033779
87MP0003172_abnormal_lysosome_physiology0.81127964
88MP0008058_abnormal_DNA_repair0.80105790
89MP0002084_abnormal_developmental_patter0.79497643
90MP0003942_abnormal_urinary_system0.77542554
91MP0000747_muscle_weakness0.75796290
92MP0001873_stomach_inflammation0.75763351
93MP0003300_gastrointestinal_ulcer0.75344958
94MP0002019_abnormal_tumor_incidence0.74103062
95MP0002697_abnormal_eye_size0.72995882
96MP0009333_abnormal_splenocyte_physiolog0.68846770
97MP0004947_skin_inflammation0.67380234
98MP0005083_abnormal_biliary_tract0.66800603
99MP0004197_abnormal_fetal_growth/weight/0.64910966
100MP0000566_synostosis0.62334132

Predicted human phenotypes

RankGene SetZ-score
1Cutaneous melanoma (HP:0012056)3.44605838
2Hyperacusis (HP:0010780)3.23683703
3Premature rupture of membranes (HP:0001788)3.14330273
4Vertebral compression fractures (HP:0002953)3.06594264
5Short nail (HP:0001799)3.01137333
6Multiple enchondromatosis (HP:0005701)2.95183425
7Long palpebral fissure (HP:0000637)2.95124626
8Achilles tendon contracture (HP:0001771)2.94122074
9Trismus (HP:0000211)2.92061349
10Back pain (HP:0003418)2.76484852
11Rough bone trabeculation (HP:0100670)2.69164595
12Distal upper limb amyotrophy (HP:0007149)2.68830386
13Upper limb amyotrophy (HP:0009129)2.68830386
14Abnormality of the Achilles tendon (HP:0005109)2.65344960
15Cholecystitis (HP:0001082)2.64054179
16Abnormal gallbladder physiology (HP:0012438)2.64054179
17Asymmetry of the thorax (HP:0001555)2.62898961
18Distal lower limb muscle weakness (HP:0009053)2.54055015
19Hand muscle atrophy (HP:0009130)2.47318660
20Selective tooth agenesis (HP:0001592)2.47225624
21Distal lower limb amyotrophy (HP:0008944)2.43971085
22Micronodular cirrhosis (HP:0001413)2.43883742
23Progressive muscle weakness (HP:0003323)2.41358632
24Centrally nucleated skeletal muscle fibers (HP:0003687)2.37726950
25Abnormality of the distal phalanges of the toes (HP:0010182)2.32669922
26Entropion (HP:0000621)2.31528937
27Ragged-red muscle fibers (HP:0003200)2.28300730
28Microvesicular hepatic steatosis (HP:0001414)2.25709927
29Abnormal trabecular bone morphology (HP:0100671)2.24228978
30Insomnia (HP:0100785)2.23145971
31Reticulocytosis (HP:0001923)2.20988368
32Thin bony cortex (HP:0002753)2.20063209
33Natal tooth (HP:0000695)2.19320220
34Flat acetabular roof (HP:0003180)2.18955731
35Aplasia/Hypoplasia of the sacrum (HP:0008517)2.17768067
36Abnormality of reticulocytes (HP:0004312)2.11965576
37Cervical subluxation (HP:0003308)2.10780508
38Abnormality of the umbilical cord (HP:0010881)2.07093110
39Spastic diplegia (HP:0001264)2.06229170
40Abnormality of glycolysis (HP:0004366)2.03232584
41Deviation of the thumb (HP:0009603)1.95452502
42J-shaped sella turcica (HP:0002680)1.95276106
43Prolonged neonatal jaundice (HP:0006579)1.94594999
44Reticulocytopenia (HP:0001896)1.92917458
45Abdominal distention (HP:0003270)1.90871467
46Fragile nails (HP:0001808)1.90829713
47Insidious onset (HP:0003587)1.90156825
48Termporal pattern (HP:0011008)1.90156825
49Progressive hearing impairment (HP:0001730)1.89292461
50Flattened epiphyses (HP:0003071)1.87662058
51Spinal cord compression (HP:0002176)1.84312852
52Advanced eruption of teeth (HP:0006288)1.83549647
53Proximal placement of thumb (HP:0009623)1.83456982
54Progressive sensorineural hearing impairment (HP:0000408)1.83144333
55Difficulty climbing stairs (HP:0003551)1.80879784
56Squamous cell carcinoma (HP:0002860)1.79790270
57Abnormality of the thoracic spine (HP:0100711)1.79259960
58Fasciculations (HP:0002380)1.79014695
59Poikiloderma (HP:0001029)1.78500925
60Broad distal phalanx of finger (HP:0009836)1.77990491
61Microglossia (HP:0000171)1.77226217
62Abnormality of cells of the erythroid lineage (HP:0012130)1.75290141
63Hypokinesia (HP:0002375)1.75024904
64Shoulder girdle muscle weakness (HP:0003547)1.74666179
65Abnormalities of placenta or umbilical cord (HP:0001194)1.73585803
66Death in infancy (HP:0001522)1.71560916
67Septate vagina (HP:0001153)1.69754281
68Deep venous thrombosis (HP:0002625)1.67831151
69Increased serum pyruvate (HP:0003542)1.67634459
70Microretrognathia (HP:0000308)1.67581885
71Sparse eyelashes (HP:0000653)1.66895464
72Increased connective tissue (HP:0009025)1.66846321
73Pterygium (HP:0001059)1.66046712
74Abnormality of carpal bone ossification (HP:0006257)1.65434866
75Ulnar bowing (HP:0003031)1.64984424
76Overlapping toe (HP:0001845)1.64625952
77Deep palmar crease (HP:0006191)1.63938320
78Protrusio acetabuli (HP:0003179)1.63700389
79Overriding aorta (HP:0002623)1.63614784
80Abnormality of liposaccharide metabolism (HP:0010968)1.61021031
81Abnormality of glycosphingolipid metabolism (HP:0004343)1.61021031
82Abnormality of glycolipid metabolism (HP:0010969)1.61021031
83Upper motor neuron abnormality (HP:0002127)1.60974045
84Generalized amyotrophy (HP:0003700)1.60474362
85Elbow flexion contracture (HP:0002987)1.59955627
86Broad face (HP:0000283)1.59471264
87Patellar dislocation (HP:0002999)1.59298939
88Ridged nail (HP:0001807)1.58599736
89Elevated alkaline phosphatase (HP:0003155)1.57908994
90Osteolytic defects of the phalanges of the hand (HP:0009771)1.57271621
91Osteolytic defects of the hand bones (HP:0009699)1.57271621
92Biconcave vertebral bodies (HP:0004586)1.56629123
93Abnormality of dentin (HP:0010299)1.55315307
94Pelvic girdle muscle weakness (HP:0003749)1.55183973
95Hyperparathyroidism (HP:0000843)1.55065989
96Hyperammonemia (HP:0001987)1.55048392
97Congenital glaucoma (HP:0001087)1.54998916
98Increased cerebral lipofuscin (HP:0011813)1.54205217
99Stridor (HP:0010307)1.52712449
100Upper limb muscle weakness (HP:0003484)1.52669014

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG14.49691209
2TRIB34.34992260
3NME23.89862549
4VRK23.29200727
5IRAK33.00590133
6EPHA22.95613036
7TESK22.71259463
8ICK2.55169273
9SIK12.37627617
10TESK12.24835776
11EEF2K2.19640742
12PAK41.98387507
13SCYL21.90337080
14ERN11.90331435
15ARAF1.82756414
16BUB11.82538359
17PKN21.69652993
18RPS6KB21.60215858
19MST1R1.50543487
20PIM21.46712110
21PRPF4B1.41494846
22FGFR41.39294976
23CDC71.32208452
24MAP3K101.29070807
25CDK71.24014028
26CDK121.22082266
27PBK1.20108303
28LMTK21.18890549
29MAP3K111.18797342
30SRPK11.17490143
31AURKA1.12631689
32LIMK11.07896276
33BCKDK1.07736593
34MAP3K81.06532086
35TAF11.03382905
36EPHB21.03145890
37BRAF1.02352914
38TAOK20.98325914
39MAP3K130.97618610
40TTN0.97470161
41PTK20.97396999
42TTK0.96395770
43PTK60.96279846
44MAPKAPK30.92544348
45KDR0.87207580
46PRKCI0.83054156
47CHEK20.82052860
48ILK0.81897346
49MTOR0.80724753
50LRRK20.80529916
51STK160.76384457
52VRK10.72248223
53NME10.71330261
54MAP3K90.70155277
55AURKB0.68463391
56LATS20.68215008
57TSSK60.68007869
58PDGFRA0.67031307
59BRSK10.65626782
60IRAK20.64564145
61EIF2AK10.63568463
62RPS6KA20.63396830
63DAPK10.62777834
64MAP2K20.62008176
65CDK40.60189478
66MAPK110.59194159
67TBK10.58793023
68DAPK30.57534860
69CDK80.57442239
70NEK10.56951065
71DYRK30.56079994
72CDK90.54310439
73TLK10.54257240
74PAK10.52087146
75ATR0.52045597
76MET0.51635773
77CHEK10.51394981
78AKT20.50453367
79CSNK1G30.48809200
80PLK10.47917111
81ABL20.45912734
82PRKD20.45056253
83TAOK10.44986613
84BMX0.43491894
85RPS6KA40.42982847
86MAP3K140.42158556
87NEK20.41806938
88CDK11A0.40447726
89STK100.40310833
90CDK150.39773420
91ZAK0.39695637
92CAMK1D0.37736507
93MAPKAPK20.37559126
94CDK180.37370736
95SIK30.36807966
96CDK140.36776261
97CSNK1A1L0.36482363
98RIPK10.35728258
99STK40.34988038
100MUSK0.34179352

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.37991602
2Base excision repair_Homo sapiens_hsa034102.70883919
3Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.66902543
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.65456201
5Proteasome_Homo sapiens_hsa030502.61613025
6Pentose phosphate pathway_Homo sapiens_hsa000302.41757760
7Biosynthesis of amino acids_Homo sapiens_hsa012302.36684120
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.34521440
9Sulfur relay system_Homo sapiens_hsa041222.22573570
10Other glycan degradation_Homo sapiens_hsa005112.07262559
11Fructose and mannose metabolism_Homo sapiens_hsa000511.91242326
12Spliceosome_Homo sapiens_hsa030401.86169073
13Carbon metabolism_Homo sapiens_hsa012001.86002074
14Galactose metabolism_Homo sapiens_hsa000521.79447916
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.77453202
16Mismatch repair_Homo sapiens_hsa034301.74712659
17Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.73981782
18Ribosome_Homo sapiens_hsa030101.66065512
19Central carbon metabolism in cancer_Homo sapiens_hsa052301.64401614
20Bladder cancer_Homo sapiens_hsa052191.61105671
21N-Glycan biosynthesis_Homo sapiens_hsa005101.55980442
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.55112484
23Pyrimidine metabolism_Homo sapiens_hsa002401.54661623
24Sulfur metabolism_Homo sapiens_hsa009201.52282310
25Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.47683091
26Thyroid cancer_Homo sapiens_hsa052161.45347660
27Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.39071240
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.38847512
29Nucleotide excision repair_Homo sapiens_hsa034201.36729429
30Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.28261807
31Glutathione metabolism_Homo sapiens_hsa004801.25672404
32Vibrio cholerae infection_Homo sapiens_hsa051101.24932098
33Cell cycle_Homo sapiens_hsa041101.22007835
34Cyanoamino acid metabolism_Homo sapiens_hsa004601.21237548
35Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.19685474
36Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.19148098
37Steroid biosynthesis_Homo sapiens_hsa001001.17006838
38RNA transport_Homo sapiens_hsa030131.14217238
39Pyruvate metabolism_Homo sapiens_hsa006201.12335325
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.12246264
41Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.11454365
42Shigellosis_Homo sapiens_hsa051311.09213871
43Chronic myeloid leukemia_Homo sapiens_hsa052201.08515515
44Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.08421629
45Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.03871995
46Acute myeloid leukemia_Homo sapiens_hsa052211.03320998
47Fatty acid elongation_Homo sapiens_hsa000621.02881063
48Systemic lupus erythematosus_Homo sapiens_hsa053221.00485520
49Endometrial cancer_Homo sapiens_hsa052130.96072078
50Folate biosynthesis_Homo sapiens_hsa007900.95807918
51RNA polymerase_Homo sapiens_hsa030200.94361436
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.94262341
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.92462005
54Viral carcinogenesis_Homo sapiens_hsa052030.91937499
55Lysosome_Homo sapiens_hsa041420.89224944
56Notch signaling pathway_Homo sapiens_hsa043300.86996244
57One carbon pool by folate_Homo sapiens_hsa006700.86311793
58Apoptosis_Homo sapiens_hsa042100.83342510
59Pancreatic cancer_Homo sapiens_hsa052120.77816359
60Epstein-Barr virus infection_Homo sapiens_hsa051690.73225214
61Small cell lung cancer_Homo sapiens_hsa052220.70431041
62mRNA surveillance pathway_Homo sapiens_hsa030150.70093390
63Non-small cell lung cancer_Homo sapiens_hsa052230.69213357
64Vitamin B6 metabolism_Homo sapiens_hsa007500.68884332
65p53 signaling pathway_Homo sapiens_hsa041150.66396135
66Alcoholism_Homo sapiens_hsa050340.64220650
67Phenylalanine metabolism_Homo sapiens_hsa003600.63576586
68Fatty acid metabolism_Homo sapiens_hsa012120.62119033
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61013884
70Hepatitis C_Homo sapiens_hsa051600.57894625
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56459326
72Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55585949
73Non-homologous end-joining_Homo sapiens_hsa034500.54436370
74Hepatitis B_Homo sapiens_hsa051610.50938164
75Homologous recombination_Homo sapiens_hsa034400.49459990
76Fatty acid biosynthesis_Homo sapiens_hsa000610.49083800
77Prion diseases_Homo sapiens_hsa050200.46852205
78Arginine and proline metabolism_Homo sapiens_hsa003300.46169662
79Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44957002
80Insulin signaling pathway_Homo sapiens_hsa049100.44117868
81Colorectal cancer_Homo sapiens_hsa052100.43620419
82Proteoglycans in cancer_Homo sapiens_hsa052050.43199207
83AMPK signaling pathway_Homo sapiens_hsa041520.42098173
84MicroRNAs in cancer_Homo sapiens_hsa052060.41889851
85Metabolic pathways_Homo sapiens_hsa011000.41005706
86HTLV-I infection_Homo sapiens_hsa051660.40802144
87Prostate cancer_Homo sapiens_hsa052150.39514676
88VEGF signaling pathway_Homo sapiens_hsa043700.38108526
89Lysine degradation_Homo sapiens_hsa003100.37437196
90Arginine biosynthesis_Homo sapiens_hsa002200.37089137
91Adherens junction_Homo sapiens_hsa045200.37073832
92Sphingolipid metabolism_Homo sapiens_hsa006000.35658118
93Salmonella infection_Homo sapiens_hsa051320.35400325
94Purine metabolism_Homo sapiens_hsa002300.33690932
95Selenocompound metabolism_Homo sapiens_hsa004500.33642506
96Herpes simplex infection_Homo sapiens_hsa051680.32216530
97Huntingtons disease_Homo sapiens_hsa050160.32044084
98Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.31619233
99Vitamin digestion and absorption_Homo sapiens_hsa049770.30756055
100Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.30100385

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