DPP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. It is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.11910504
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.11910504
3L-phenylalanine metabolic process (GO:0006558)5.85276781
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.85276781
5triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.75545129
6aromatic amino acid family catabolic process (GO:0009074)5.67896742
7tryptophan catabolic process (GO:0006569)5.26634285
8indole-containing compound catabolic process (GO:0042436)5.26634285
9indolalkylamine catabolic process (GO:0046218)5.26634285
10kynurenine metabolic process (GO:0070189)5.10012143
11intestinal cholesterol absorption (GO:0030299)5.09002129
12urea cycle (GO:0000050)4.98816761
13urea metabolic process (GO:0019627)4.98816761
14tryptophan metabolic process (GO:0006568)4.96987159
15alpha-linolenic acid metabolic process (GO:0036109)4.96311470
16high-density lipoprotein particle remodeling (GO:0034375)4.84170499
17cysteine metabolic process (GO:0006534)4.83244137
18bile acid biosynthetic process (GO:0006699)4.75897560
19fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.72956212
20lipoprotein transport (GO:0042953)4.70576846
21regulation of triglyceride catabolic process (GO:0010896)4.63738741
22phospholipid efflux (GO:0033700)4.61673781
23negative regulation of sterol transport (GO:0032372)4.61044286
24negative regulation of cholesterol transport (GO:0032375)4.61044286
25drug catabolic process (GO:0042737)4.60712629
26nitrogen cycle metabolic process (GO:0071941)4.55522448
27regulation of cholesterol esterification (GO:0010872)4.54398199
28sulfur amino acid catabolic process (GO:0000098)4.54298791
29epoxygenase P450 pathway (GO:0019373)4.53550149
30glyoxylate metabolic process (GO:0046487)4.52550029
31homocysteine metabolic process (GO:0050667)4.48371932
32bile acid metabolic process (GO:0008206)4.34900388
33intestinal absorption (GO:0050892)4.33090021
34reverse cholesterol transport (GO:0043691)4.32128073
35bile acid and bile salt transport (GO:0015721)4.30141389
36negative regulation of fibrinolysis (GO:0051918)4.28623632
37complement activation, alternative pathway (GO:0006957)4.27370918
38regulation of protein activation cascade (GO:2000257)4.21761897
39peptidyl-glutamic acid carboxylation (GO:0017187)4.16696397
40protein carboxylation (GO:0018214)4.16696397
41plasma lipoprotein particle remodeling (GO:0034369)4.14617123
42protein-lipid complex remodeling (GO:0034368)4.14617123
43macromolecular complex remodeling (GO:0034367)4.14617123
44lysine metabolic process (GO:0006553)4.14433785
45lysine catabolic process (GO:0006554)4.14433785
46serine family amino acid catabolic process (GO:0009071)4.07168765
47cholesterol efflux (GO:0033344)4.06899478
48regulation of fibrinolysis (GO:0051917)4.05945190
49plasma lipoprotein particle assembly (GO:0034377)4.03668767
50aromatic amino acid family metabolic process (GO:0009072)4.01842096
51fat-soluble vitamin biosynthetic process (GO:0042362)4.00968371
52regulation of bile acid biosynthetic process (GO:0070857)3.96966863
53regulation of complement activation (GO:0030449)3.96414037
54angiotensin maturation (GO:0002003)3.95927436
55acylglycerol homeostasis (GO:0055090)3.95792699
56triglyceride homeostasis (GO:0070328)3.95792699
57amino-acid betaine metabolic process (GO:0006577)3.92867071
58regulation of cholesterol homeostasis (GO:2000188)3.89030023
59positive regulation of triglyceride lipase activity (GO:0061365)3.88964724
60positive regulation of lipoprotein lipase activity (GO:0051006)3.88964724
61antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.86595555
62antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.86595555
63glucuronate metabolic process (GO:0019585)3.83992468
64uronic acid metabolic process (GO:0006063)3.83992468
65adhesion of symbiont to host cell (GO:0044650)3.81069296
66virion attachment to host cell (GO:0019062)3.81069296
67drug transmembrane transport (GO:0006855)3.72156864
68tyrosine metabolic process (GO:0006570)3.70812472
69protein-lipid complex assembly (GO:0065005)3.69183195
70cholesterol homeostasis (GO:0042632)3.66731627
71indolalkylamine metabolic process (GO:0006586)3.66559018
72alpha-amino acid catabolic process (GO:1901606)3.65727253
73lipoprotein metabolic process (GO:0042157)3.65477782
74adhesion of symbiont to host (GO:0044406)3.63475170
75flavonoid metabolic process (GO:0009812)3.62357440
76sterol homeostasis (GO:0055092)3.61051136
77phospholipid homeostasis (GO:0055091)3.59941114
78ethanol oxidation (GO:0006069)3.58299654
79cellular glucuronidation (GO:0052695)3.57345367
80very-low-density lipoprotein particle assembly (GO:0034379)3.51013340
81benzene-containing compound metabolic process (GO:0042537)3.50580005
82antigen processing and presentation of endogenous antigen (GO:0019883)3.49498393
83plasma lipoprotein particle clearance (GO:0034381)3.49295404
84diacylglycerol metabolic process (GO:0046339)3.48533851
85glycine metabolic process (GO:0006544)3.47466204
86urate metabolic process (GO:0046415)3.43184861
87valine metabolic process (GO:0006573)3.43159565
88drug metabolic process (GO:0017144)3.42439788
89peptide hormone processing (GO:0016486)3.42024723
90regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.41623177
91serine family amino acid metabolic process (GO:0009069)3.40246226
92cellular modified amino acid catabolic process (GO:0042219)3.39820041
93amine catabolic process (GO:0009310)3.39657395
94cellular biogenic amine catabolic process (GO:0042402)3.39657395
95cellular amino acid catabolic process (GO:0009063)3.38163367
96positive regulation of lipid catabolic process (GO:0050996)3.36380361
97glomerular visceral epithelial cell development (GO:0072015)3.33491456
98exogenous drug catabolic process (GO:0042738)3.33125206
99glutamate metabolic process (GO:0006536)3.32020880
100plasma lipoprotein particle organization (GO:0071827)3.30160916
101serine family amino acid biosynthetic process (GO:0009070)3.28176388
102cellular ketone body metabolic process (GO:0046950)3.27662758
103COPII vesicle coating (GO:0048208)3.26315928
104dicarboxylic acid biosynthetic process (GO:0043650)3.26019884
105negative regulation of protein activation cascade (GO:2000258)3.24974005
106hormone catabolic process (GO:0042447)3.24392291
107imidazole-containing compound metabolic process (GO:0052803)3.23222383
108regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.21101106
109endocrine process (GO:0050886)3.21101106
110regulation of systemic arterial blood pressure by hormone (GO:0001990)3.21101106
111NADH metabolic process (GO:0006734)3.19381619
112drug transport (GO:0015893)3.17476438
113regulation of guanylate cyclase activity (GO:0031282)3.17425204
114short-chain fatty acid metabolic process (GO:0046459)3.17316569
115protein-lipid complex subunit organization (GO:0071825)3.14879478
116regulation of plasminogen activation (GO:0010755)3.14324673
117arginine metabolic process (GO:0006525)3.12554003
118low-density lipoprotein particle remodeling (GO:0034374)3.11864369
119sphingomyelin metabolic process (GO:0006684)3.10219642
120oligosaccharide catabolic process (GO:0009313)3.08486939
121peptide catabolic process (GO:0043171)3.06717383
122negative regulation of complement activation (GO:0045916)2.99218291
123glycosphingolipid catabolic process (GO:0046479)2.90257583
124fructose metabolic process (GO:0006000)2.86681749
125negative regulation of hemostasis (GO:1900047)2.81209156
126negative regulation of blood coagulation (GO:0030195)2.81209156
127negative regulation of fatty acid transport (GO:2000192)2.80030464
128glycolipid catabolic process (GO:0019377)2.78019413
129negative regulation of coagulation (GO:0050819)2.77476403
130* regulation of extracellular matrix disassembly (GO:0010715)2.76968365
131regulation of transforming growth factor beta1 production (GO:0032908)2.76853196
132cellular zinc ion homeostasis (GO:0006882)2.73320232
133positive regulation of extracellular matrix organization (GO:1903055)2.71215796
134macroautophagy (GO:0016236)2.69006657
135negative regulation of wound healing (GO:0061045)2.66472665
136glutamine family amino acid biosynthetic process (GO:0009084)2.65322181
137regulation of systemic arterial blood pressure (GO:0003073)2.65002536
138fibrinolysis (GO:0042730)2.62477490
139skin morphogenesis (GO:0043589)2.60285993
140positive regulation of fatty acid biosynthetic process (GO:0045723)2.59388034
141sequestering of extracellular ligand from receptor (GO:0035581)2.57349259
142regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.56752125
143regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.55545353
144cell adhesion mediated by integrin (GO:0033627)2.52063921
145regulation of cholesterol metabolic process (GO:0090181)2.46885918
146positive regulation of guanylate cyclase activity (GO:0031284)2.46609327

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.20827135
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.61692984
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.04321878
4EGR1_23403033_ChIP-Seq_LIVER_Mouse5.61921296
5LXR_22158963_ChIP-Seq_LIVER_Mouse5.27558178
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.14573814
7TRIM28_21343339_ChIP-Seq_HEK293_Human3.89256131
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.73678602
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.71812164
10IRF8_22096565_ChIP-ChIP_GC-B_Human3.28918455
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.25849504
12CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.06082113
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.82978961
14GATA1_22025678_ChIP-Seq_K562_Human2.60388246
15PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.41510943
16SMAD_19615063_ChIP-ChIP_OVARY_Human2.33692167
17HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.29697518
18CDX2_19796622_ChIP-Seq_MESCs_Mouse2.26596324
19RARG_19884340_ChIP-ChIP_MEFs_Mouse2.19754734
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.13884809
21CLOCK_20551151_ChIP-Seq_293T_Human1.97117990
22IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.87439029
23* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.84093135
24FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.81741464
25STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.81173898
26TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.80047673
27SOX2_27498859_Chip-Seq_STOMACH_Mouse1.71883739
28* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.65147384
29* CJUN_26792858_Chip-Seq_BT549_Human1.64945062
30TP63_17297297_ChIP-ChIP_HaCaT_Human1.62001639
31TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57920717
32STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.56783389
33FOXA2_19822575_ChIP-Seq_HepG2_Human1.54425067
34BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.51910407
35ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.47272241
36* GATA4_25053715_ChIP-Seq_YYC3_Human1.45294220
37ZNF217_24962896_ChIP-Seq_MCF-7_Human1.36702126
38HIF1A_21447827_ChIP-Seq_MCF-7_Human1.35695489
39* CDX2_20551321_ChIP-Seq_CACO-2_Human1.35385034
40NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.34145361
41SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.33511669
42* HNF4A_19822575_ChIP-Seq_HepG2_Human1.32451365
43MYC_22102868_ChIP-Seq_BL_Human1.31889915
44TP53_18474530_ChIP-ChIP_U2OS_Human1.30093376
45* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.28638289
46CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.25530982
47RUNX_20019798_ChIP-Seq_JUKART_Human1.22377528
48NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.20263577
49TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.20237765
50* TCF4_18268006_ChIP-ChIP_LS174T_Human1.19355083
51IRF8_27001747_Chip-Seq_BMDM_Mouse1.19158068
52EP300_21415370_ChIP-Seq_HL-1_Mouse1.18703367
53NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.17181256
54MYB_26560356_Chip-Seq_TH1_Human1.16861371
55E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.15758725
56GATA6_25053715_ChIP-Seq_YYC3_Human1.15709397
57ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.14640680
58MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.13868418
59MAF_26560356_Chip-Seq_TH1_Human1.13827343
60MYB_26560356_Chip-Seq_TH2_Human1.13563133
61TP53_16413492_ChIP-PET_HCT116_Human1.13348750
62CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.12500774
63FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.12210831
64RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.11915557
65SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.11879759
66NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.10648340
67NRF2_20460467_ChIP-Seq_MEFs_Mouse1.10648340
68CDX2_22108803_ChIP-Seq_LS180_Human1.10469905
69BRD4_27068464_Chip-Seq_AML-cells_Mouse1.10438319
70THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.08421434
71ESR1_21235772_ChIP-Seq_MCF-7_Human1.08320807
72JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08289131
73* BRD4_25478319_ChIP-Seq_HGPS_Human1.07925272
74* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07494908
75* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.03677262
76PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02111474
77* TP63_23658742_ChIP-Seq_EP156T_Human1.01466626
78UTX_26944678_Chip-Seq_JUKART_Human1.01203108
79P63_26484246_Chip-Seq_KERATINOCYTES_Human1.01071087
80ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01027651
81PCGF2_27294783_Chip-Seq_ESCs_Mouse1.01006994
82SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.00308080
83SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.00308080
84FOXO3_23340844_ChIP-Seq_DLD1_Human1.00170853
85IRF8_21731497_ChIP-ChIP_J774_Mouse0.98334773
86MYB_21317192_ChIP-Seq_ERMYB_Mouse0.98222092
87VDR_24787735_ChIP-Seq_THP-1_Human0.97204777
88BP1_19119308_ChIP-ChIP_Hs578T_Human0.96401419
89RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.95410412
90* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.93146355
91SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.91642646
92SCL_19346495_ChIP-Seq_HPC-7_Human0.91251859
93SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.89592392
94SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.88465084
95GATA2_22383799_ChIP-Seq_G1ME_Mouse0.88459268
96EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.88337017
97RXRA_24833708_ChIP-Seq_LIVER_Mouse0.88103446
98ESR2_21235772_ChIP-Seq_MCF-7_Human0.87810009
99GATA2_19941826_ChIP-Seq_K562_Human0.87059946
100STAT4_19710469_ChIP-ChIP_TH1__Mouse0.86042760
101KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.85683787
102* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.84461715
103CTNNB1_20460455_ChIP-Seq_HCT116_Human0.84226919
104VDR_21846776_ChIP-Seq_THP-1_Human0.84045660
105NFIB_24661679_ChIP-Seq_LUNG_Mouse0.83283229
106PIAS1_25552417_ChIP-Seq_VCAP_Human0.83271469
107* TCF7_22412390_ChIP-Seq_EML_Mouse0.81897888
108GATA3_24758297_ChIP-Seq_MCF-7_Human0.81759507
109PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.80967319
110LXR_22292898_ChIP-Seq_THP-1_Human0.80496159
111AHR_22903824_ChIP-Seq_MCF-7_Human0.79359731
112KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.79211979
113* SOX2_20726797_ChIP-Seq_SW620_Human0.78980330
114GATA1_22383799_ChIP-Seq_G1ME_Mouse0.78839306
115GATA1_19941827_ChIP-Seq_MEL_Mouse0.78735836
116FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.78234135
117GATA1_19941826_ChIP-Seq_K562_Human0.77666863
118PPAR_26484153_Chip-Seq_NCI-H1993_Human0.77593715
119GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.77548189
120ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.76695282
121* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.76639997
122FOXA1_25552417_ChIP-Seq_VCAP_Human0.75465190
123ELF1_17652178_ChIP-ChIP_JURKAT_Human0.75455557
124Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.75439222
125GATA3_27048872_Chip-Seq_THYMUS_Human0.73653506
126RARA_24833708_ChIP-Seq_LIVER_Mouse0.72386901
127TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.71284931
128* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.70647465
129RUNX1_22412390_ChIP-Seq_EML_Mouse0.70344828
130* GATA2_21666600_ChIP-Seq_HMVEC_Human0.69758264
131* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.69503884
132LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.69252618
133VDR_24763502_ChIP-Seq_THP-1_Human0.68327009
134KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.67142482
135FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.67138766
136PU_27001747_Chip-Seq_BMDM_Mouse0.66893670
137STAT3_1855785_ChIP-Seq_MESCs_Mouse0.66780529
138CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.65608492
139RARB_24833708_ChIP-Seq_LIVER_Mouse0.64144926
140CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.63905318
141TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.63838531
142SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.62534224

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.52851076
2MP0002139_abnormal_hepatobiliary_system6.65358357
3MP0005085_abnormal_gallbladder_physiolo5.18535250
4MP0005365_abnormal_bile_salt4.95606340
5MP0008438_abnormal_cutaneous_collagen4.15509208
6MP0008875_abnormal_xenobiotic_pharmacok4.11242910
7MP0003252_abnormal_bile_duct3.75156260
8MP0001666_abnormal_nutrient_absorption3.26194288
9MP0003806_abnormal_nucleotide_metabolis3.05279436
10MP0010329_abnormal_lipoprotein_level3.03358728
11MP0009840_abnormal_foam_cell2.98981822
12MP0002138_abnormal_hepatobiliary_system2.54793256
13MP0005332_abnormal_amino_acid2.49379854
14MP0004272_abnormal_basement_membrane2.28266171
15MP0003191_abnormal_cellular_cholesterol2.07299714
16MP0003195_calcinosis2.00466322
17MP0000609_abnormal_liver_physiology1.99718853
18MP0004019_abnormal_vitamin_homeostasis1.99507526
19MP0005083_abnormal_biliary_tract1.94986719
20MP0009643_abnormal_urine_homeostasis1.81690691
21MP0001958_emphysema1.79179894
22MP0005275_abnormal_skin_tensile1.77677357
23MP0002118_abnormal_lipid_homeostasis1.72165724
24MP0005503_abnormal_tendon_morphology1.69115257
25MP0005058_abnormal_lysosome_morphology1.62647990
26MP0009384_cardiac_valve_regurgitation1.62038532
27MP0005257_abnormal_intraocular_pressure1.60185292
28MP0005319_abnormal_enzyme/_coenzyme1.58874069
29MP0003868_abnormal_feces_composition1.51795985
30MP0003300_gastrointestinal_ulcer1.50223977
31MP0005023_abnormal_wound_healing1.44345984
32MP0009780_abnormal_chondrocyte_physiolo1.39755903
33MP0001764_abnormal_homeostasis1.37638155
34MP0003950_abnormal_plasma_membrane1.35748865
35MP0010234_abnormal_vibrissa_follicle1.34306683
36MP0002166_altered_tumor_susceptibility1.33011874
37MP0005584_abnormal_enzyme/coenzyme_acti1.29643975
38MP0004264_abnormal_extraembryonic_tissu1.29593319
39MP0002933_joint_inflammation1.28538429
40MP0001835_abnormal_antigen_presentation1.25399570
41MP0003279_aneurysm1.25084219
42MP0003183_abnormal_peptide_metabolism1.22546407
43MP0005409_darkened_coat_color1.21186576
44MP0002896_abnormal_bone_mineralization1.21021813
45MP0000685_abnormal_immune_system1.20014881
46MP0002998_abnormal_bone_remodeling1.18452499
47MP0002136_abnormal_kidney_physiology1.17220001
48MP0008469_abnormal_protein_level1.14336876
49MP0010368_abnormal_lymphatic_system1.13554522
50MP0000598_abnormal_liver_morphology1.13496866
51MP0001533_abnormal_skeleton_physiology1.13250304
52MP0009697_abnormal_copulation1.12244209
53MP0005164_abnormal_response_to1.10385431
54MP0003172_abnormal_lysosome_physiology1.08115711
55MP0005084_abnormal_gallbladder_morpholo1.07495254
56MP0005451_abnormal_body_composition1.07383058
57MP0009764_decreased_sensitivity_to1.06796742
58MP0001664_abnormal_digestion1.05794517
59MP0005636_abnormal_mineral_homeostasis1.05498294
60MP0003436_decreased_susceptibility_to1.05284860
61MP0000538_abnormal_urinary_bladder1.03777283
62MP0010155_abnormal_intestine_physiology1.03053921
63MP0001542_abnormal_bone_strength1.01546365
64MP0005464_abnormal_platelet_physiology1.00054022
65MP0004147_increased_porphyrin_level0.99536123
66MP0000013_abnormal_adipose_tissue0.99007605
67MP0001800_abnormal_humoral_immune0.98575844
68MP0001873_stomach_inflammation0.97431260
69MP0004947_skin_inflammation0.97220585
70MP0001756_abnormal_urination0.96908905
71MP0005220_abnormal_exocrine_pancreas0.94364379
72MP0003705_abnormal_hypodermis_morpholog0.94287229
73MP0002876_abnormal_thyroid_physiology0.92362414
74MP0001790_abnormal_immune_system0.91179508
75MP0005387_immune_system_phenotype0.91179508
76* MP0009642_abnormal_blood_homeostasis0.90373345
77MP0003091_abnormal_cell_migration0.89626213
78MP0002254_reproductive_system_inflammat0.89259645
79MP0001661_extended_life_span0.89017356
80MP0001845_abnormal_inflammatory_respons0.88383661
81MP0009785_altered_susceptibility_to0.87872482
82MP0010386_abnormal_urinary_bladder0.87182776
83MP0003866_abnormal_defecation0.86416919
84MP0009763_increased_sensitivity_to0.86330123
85MP0003566_abnormal_cell_adhesion0.84194120
86MP0003186_abnormal_redox_activity0.83021317
87MP0003879_abnormal_hair_cell0.82991046
88MP0005671_abnormal_response_to0.82371386
89MP0002089_abnormal_postnatal_growth/wei0.80198970
90MP0009765_abnormal_xenobiotic_induced0.79431177
91MP0003724_increased_susceptibility_to0.79105942
92MP0003763_abnormal_thymus_physiology0.79053688
93MP0003656_abnormal_erythrocyte_physiolo0.78189397
94MP0002006_tumorigenesis0.77998519
95MP0005025_abnormal_response_to0.77328896
96* MP0002078_abnormal_glucose_homeostasis0.76980713
97MP0004043_abnormal_pH_regulation0.76507939
98MP0005408_hypopigmentation0.76253714
99MP0004858_abnormal_nervous_system0.74954183
100MP0004782_abnormal_surfactant_physiolog0.74446458
101MP0002168_other_aberrant_phenotype0.73975096
102MP0005647_abnormal_sex_gland0.73549330
103MP0002295_abnormal_pulmonary_circulatio0.73365916
104MP0000249_abnormal_blood_vessel0.73078025
105MP0002723_abnormal_immune_serum0.72108917
106MP0002060_abnormal_skin_morphology0.70585016
107MP0003045_fibrosis0.69952062
108MP0001765_abnormal_ion_homeostasis0.69027044
109MP0003941_abnormal_skin_development0.68894369
110MP0002971_abnormal_brown_adipose0.68751157
111MP0000604_amyloidosis0.68219825
112MP0002928_abnormal_bile_duct0.68104955
113MP0002452_abnormal_antigen_presenting0.68033644
114MP0005165_increased_susceptibility_to0.66028049
115MP0005390_skeleton_phenotype0.65779445
116MP0004883_abnormal_blood_vessel0.65664386
117MP0000858_altered_metastatic_potential0.65012675
118MP0008004_abnormal_stomach_pH0.64789302
119MP0009333_abnormal_splenocyte_physiolog0.64719686
120MP0002135_abnormal_kidney_morphology0.63118647
121MP0010352_gastrointestinal_tract_polyps0.62752011
122MP0005334_abnormal_fat_pad0.61938720
123MP0000689_abnormal_spleen_morphology0.61418805
124MP0006054_spinal_hemorrhage0.61209932
125MP0000716_abnormal_immune_system0.60937620
126MP0001819_abnormal_immune_cell0.59106579
127MP0002420_abnormal_adaptive_immunity0.59076116
128MP0000477_abnormal_intestine_morphology0.58906125
129MP0005448_abnormal_energy_balance0.57855094
130MP0002419_abnormal_innate_immunity0.57551210
131MP0005000_abnormal_immune_tolerance0.57459667
132MP0001944_abnormal_pancreas_morphology0.57231285
133MP0008961_abnormal_basal_metabolism0.55760278
134MP0002398_abnormal_bone_marrow0.54255300
135MP0002722_abnormal_immune_system0.53901531
136MP0005376_homeostasis/metabolism_phenot0.53833490
137MP0000230_abnormal_systemic_arterial0.52419066
138MP0006082_CNS_inflammation0.51686407
139MP0001879_abnormal_lymphatic_vessel0.51667895
140MP0003638_abnormal_response/metabolism_0.51438598
141MP0002429_abnormal_blood_cell0.51274829
142MP0001853_heart_inflammation0.51041490
143MP0005166_decreased_susceptibility_to0.50889930

Predicted human phenotypes

RankGene SetZ-score
1Hypobetalipoproteinemia (HP:0003563)5.86662567
2Intrahepatic cholestasis (HP:0001406)5.84366049
3Deep venous thrombosis (HP:0002625)5.80208480
4Abnormality of aromatic amino acid family metabolism (HP:0004338)5.77653164
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.52426998
6Xanthomatosis (HP:0000991)4.99687053
7Prolonged partial thromboplastin time (HP:0003645)4.76284911
8Abnormality of glutamine family amino acid metabolism (HP:0010902)4.68206100
9Protrusio acetabuli (HP:0003179)4.21065120
10Conjugated hyperbilirubinemia (HP:0002908)4.14206170
11Fat malabsorption (HP:0002630)3.97937880
12Hypolipoproteinemia (HP:0010981)3.86966399
13Hyperlipoproteinemia (HP:0010980)3.83513221
14Complement deficiency (HP:0004431)3.82097352
15Hypoglycemic coma (HP:0001325)3.80884640
16Hyperglycinuria (HP:0003108)3.68060532
17Abnormality of the common coagulation pathway (HP:0010990)3.67899794
18Abnormality of sulfur amino acid metabolism (HP:0004339)3.64160178
19Epidermoid cyst (HP:0200040)3.60594139
20Hyperammonemia (HP:0001987)3.60203951
21Joint hemorrhage (HP:0005261)3.51885200
22Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.50329901
23Ketosis (HP:0001946)3.49826578
24Abnormality of aspartate family amino acid metabolism (HP:0010899)3.39536525
25Premature rupture of membranes (HP:0001788)3.34988361
26Abnormality of serine family amino acid metabolism (HP:0010894)3.32242938
27Abnormality of glycine metabolism (HP:0010895)3.32242938
28Abnormality of the intrinsic pathway (HP:0010989)3.25085215
29Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.23411966
30Acanthocytosis (HP:0001927)3.23293338
31Aortic dissection (HP:0002647)3.21679324
32Hyperglycinemia (HP:0002154)3.16005587
33Aortic aneurysm (HP:0004942)3.09691846
34Hypercholesterolemia (HP:0003124)3.03305922
35Abnormality of pyrimidine metabolism (HP:0004353)2.95673538
36Abnormality of nucleobase metabolism (HP:0010932)2.95507270
37Abnormality of purine metabolism (HP:0004352)2.95424136
38Hyperbilirubinemia (HP:0002904)2.94555777
39Abnormality of fatty-acid metabolism (HP:0004359)2.94058265
40Thin bony cortex (HP:0002753)2.90662602
41Vertebral compression fractures (HP:0002953)2.90642857
42Ketoacidosis (HP:0001993)2.90130980
43Autoimmune thrombocytopenia (HP:0001973)2.87975107
44Abnormality of complement system (HP:0005339)2.82134782
45Glomerulonephritis (HP:0000099)2.79141187
46Vascular tortuosity (HP:0004948)2.79011062
47Abnormality of methionine metabolism (HP:0010901)2.77263667
48Hypophosphatemic rickets (HP:0004912)2.76756257
49Abnormality of proline metabolism (HP:0010907)2.73916517
50Hydroxyprolinuria (HP:0003080)2.73916517
51Focal segmental glomerulosclerosis (HP:0000097)2.72518854
52Hypoalphalipoproteinemia (HP:0003233)2.70922008
53Mucopolysacchariduria (HP:0008155)2.70345467
54Urinary glycosaminoglycan excretion (HP:0003541)2.70345467
55Hypoglycemic seizures (HP:0002173)2.68989265
56Mesangial abnormality (HP:0001966)2.68477030
57Widely patent fontanelles and sutures (HP:0004492)2.67796747
58Peritonitis (HP:0002586)2.64623501
59Malnutrition (HP:0004395)2.60051650
60Nephritis (HP:0000123)2.59839789
61Cervical subluxation (HP:0003308)2.59103303
62Myocardial infarction (HP:0001658)2.57424781
63Steatorrhea (HP:0002570)2.55267013
64Abnormality of mucopolysaccharide metabolism (HP:0011020)2.54956007
65Abnormality of polysaccharide metabolism (HP:0011012)2.54956007
66Abnormality of glycosaminoglycan metabolism (HP:0004371)2.54956007
67Gout (HP:0001997)2.54237731
68Late onset (HP:0003584)2.53837783
69Proximal tubulopathy (HP:0000114)2.52781259
70Wormian bones (HP:0002645)2.46154187
71Arterial tortuosity (HP:0005116)2.45841670
72Dysostosis multiplex (HP:0000943)2.45549758
73Hypophosphatemia (HP:0002148)2.41855692
74Glomerulosclerosis (HP:0000096)2.41789949
75Metabolic acidosis (HP:0001942)2.39719158
76Abnormality of carpal bone ossification (HP:0006257)2.39286755
77Hepatocellular carcinoma (HP:0001402)2.38886060
78Vacuolated lymphocytes (HP:0001922)2.38663382
79Abnormality of vitamin metabolism (HP:0100508)2.37551845
80Ovoid vertebral bodies (HP:0003300)2.36002509
81Pigmentary retinal degeneration (HP:0001146)2.34211381
82Delayed CNS myelination (HP:0002188)2.34159212
83Esophageal varix (HP:0002040)2.34044113
84Rickets (HP:0002748)2.32798894
85Mitral stenosis (HP:0001718)2.32388528
86Potter facies (HP:0002009)2.30617851
87Facial shape deformation (HP:0011334)2.30617851
88Hypoplasia of the thymus (HP:0000778)2.29463530
89Flat acetabular roof (HP:0003180)2.26856625
90Abnormality of vitamin B metabolism (HP:0004340)2.25556017
91Ileus (HP:0002595)2.23877071
92Polycythemia (HP:0001901)2.20157298
93Hyperinsulinemic hypoglycemia (HP:0000825)2.19017962
94Generalized aminoaciduria (HP:0002909)2.15935308
95Neonatal short-limb short stature (HP:0008921)2.15766966
96Vascular calcification (HP:0004934)2.14961626
97Metaphyseal irregularity (HP:0003025)2.14089443
98Gingival bleeding (HP:0000225)2.13053780
99Abnormality of urine glucose concentration (HP:0011016)2.12979815
100Skin nodule (HP:0200036)2.12909324
101Follicular hyperkeratosis (HP:0007502)2.12062517
102Protuberant abdomen (HP:0001538)2.11953035
103Hypochromic microcytic anemia (HP:0004840)2.11170875
104Femoral bowing (HP:0002980)2.09805506
105Pancreatitis (HP:0001733)2.08924395
106Spondylolisthesis (HP:0003302)2.08575310
107Abnormality of glycosphingolipid metabolism (HP:0004343)2.08425745
108Abnormality of glycolipid metabolism (HP:0010969)2.08425745
109Abnormality of liposaccharide metabolism (HP:0010968)2.08425745
110Thrombophlebitis (HP:0004418)2.07582075
111Flared iliac wings (HP:0002869)2.07496140
112T lymphocytopenia (HP:0005403)2.07322330
113Poikilocytosis (HP:0004447)2.07238685
114Symptomatic seizures (HP:0011145)2.06765133
115Osteolytic defects of the phalanges of the hand (HP:0009771)2.04794157
116Osteolytic defects of the hand bones (HP:0009699)2.04794157
117Abnormality of the vitamin B12 metabolism (HP:0004341)2.04364756
118Wide cranial sutures (HP:0010537)2.02990355
119Enlarged epiphyses (HP:0010580)2.02270124
120Abnormality of T cell number (HP:0011839)2.00640763
121Recurrent viral infections (HP:0004429)2.00188732
122Dicarboxylic aciduria (HP:0003215)2.00039962
123Abnormality of dicarboxylic acid metabolism (HP:0010995)2.00039962
124Soft skin (HP:0000977)1.99485193
125Abnormality of the acetabulum (HP:0003170)1.99364742
126Spastic diplegia (HP:0001264)1.98754811
127Osteomalacia (HP:0002749)1.97440247
128Cupped ribs (HP:0000887)1.97205637
129Spontaneous abortion (HP:0005268)1.96785891
130Abnormality of serum amino acid levels (HP:0003112)1.96725928
131Ankle contracture (HP:0006466)1.95926670
132Abdominal distention (HP:0003270)1.94759777
133Abnormality of endocrine pancreas physiology (HP:0012093)1.93406309
134Abnormality of the pancreatic islet cells (HP:0006476)1.93406309
135Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.93172519
136Sensorimotor neuropathy (HP:0007141)1.93163736
137Systemic lupus erythematosus (HP:0002725)1.92687646
138Irritability (HP:0000737)1.92401292
139Alkalosis (HP:0001948)1.91478677
140Recurrent gram-negative bacterial infections (HP:0005420)1.91157127
141Abnormal tarsal ossification (HP:0008369)1.90272650
142Chronic diarrhea (HP:0002028)1.90042255
143Abnormality of B cell number (HP:0010975)1.89707444
144B lymphocytopenia (HP:0010976)1.89707444
145Abnormal enzyme/coenzyme activity (HP:0012379)1.89622469
146Hypoalbuminemia (HP:0003073)1.88223566
147Abnormal albumin level (HP:0012116)1.88223566
148Spontaneous hematomas (HP:0007420)1.88064232
149Joint swelling (HP:0001386)1.87252231
150Delayed closure of the anterior fontanelle (HP:0001476)1.86895464
151Abnormal hand bone ossification (HP:0010660)1.86444454
152Aneurysm (HP:0002617)1.86254783
153Abnormal ossification of hand bones (HP:0005921)1.85160833
154Increased mean platelet volume (HP:0011877)1.85127100
155Cardiovascular calcification (HP:0011915)1.84946647
156Autoimmune hemolytic anemia (HP:0001890)1.84890945
157Abnormal platelet volume (HP:0011876)1.83994224
158Abnormal glucose tolerance (HP:0001952)1.83969857
159Nephrolithiasis (HP:0000787)1.83728038
160Hemorrhage of the eye (HP:0011885)1.83478568
161Glycosuria (HP:0003076)1.81902765
162Hypotension (HP:0002615)1.81354959
163Dilatation of the ascending aorta (HP:0005111)1.81295011
164Osteoarthritis (HP:0002758)1.80296641

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN13.85704625
2FGFR43.72022019
3MAP3K103.33650009
4FRK3.30005356
5ACVR1B3.26854373
6BCKDK3.03343714
7TAOK32.92158498
8MAP4K12.88827345
9PDGFRA2.60342359
10GRK62.59064934
11MST42.55178934
12TYK22.51171628
13SIK12.47222529
14DDR22.40506317
15FLT32.12502776
16MAP3K122.09581264
17PKN22.06931221
18PTK61.78278255
19EEF2K1.71173617
20STK101.67629392
21INSRR1.61563852
22MAPK111.60017149
23JAK31.58934844
24JAK11.58532251
25MAP3K141.54198360
26TBK11.51590475
27ZAP701.48393469
28MST1R1.43610847
29LRRK21.42177808
30KDR1.41383068
31TRIB31.41054831
32FGFR31.39361213
33CDC42BPA1.39259541
34PIK3CA1.36997149
35MAP3K71.33167893
36MET1.30881425
37IKBKE1.28967407
38ITK1.28765727
39NLK1.27702150
40CSK1.25293302
41EPHB11.20842907
42BTK1.17260712
43AKT31.16726066
44TGFBR21.15292913
45CSF1R1.14808400
46FGFR21.14084330
47JAK21.12085420
48STK391.11732445
49TRPM71.11555713
50STK381.09662153
51PDGFRB1.09416650
52PTK21.08216565
53MAP3K131.07767183
54PIK3CG1.02024017
55WNK40.99980431
56WNK10.94871079
57ICK0.91468595
58PDPK10.90541006
59NEK90.89496087
60DYRK1B0.86869458
61IRAK30.86047469
62RIPK10.85603643
63PRKAA20.83968212
64SYK0.81914420
65TXK0.81539350
66NUAK10.81428835
67TIE10.79752273
68CHUK0.76905681
69TGFBR10.76772221
70MAP2K30.76061649
71MYLK0.75929040
72TESK10.72699706
73MAPK150.71888530
74PRKD20.70931464
75TEC0.70622140
76BLK0.68786434
77LATS10.68779421
78PRPF4B0.68098411
79FGFR10.67833516
80MAP3K10.67365430
81PAK20.67329737
82RET0.67263901
83MAPK40.65846480
84CDK60.65278073
85KIT0.65135660
86PAK40.64900557
87MAP3K30.63123998
88PRKCQ0.63121610
89IKBKB0.62921388
90PRKG20.62804348
91EPHA30.61119453
92CDK40.60270225
93STK240.60095314
94MELK0.57516273
95LCK0.57387465
96PIM10.57258720
97MAP3K20.55871801
98SCYL20.55718194
99SGK30.54829006
100ERBB40.54067708
101FER0.54032080
102HIPK20.51737333
103WNK30.51092724
104ADRBK20.50835276
105EPHA20.50226817
106STK40.49964793
107PASK0.49780184
108MAPK70.49618811
109SRC0.49558234
110TESK20.47018896
111BCR0.46449721
112MAP3K80.45797103
113MATK0.45455342
114PDK10.45133140
115IGF1R0.44932420
116PRKACG0.44467822
117TYRO30.43877076
118NTRK10.42805397
119CAMKK20.42106775
120MAP2K20.41655853
121MAPKAPK20.41593806
122GRK70.41480327
123LYN0.41124372
124BMPR20.39469735
125PRKAA10.38366807
126PDK20.38075910
127RPS6KA40.36982812
128GSK3A0.36817038
129MAP2K60.36719745
130PRKCH0.35760128
131GRK10.35728875
132ERBB20.35682736
133RPS6KB20.35387690
134LMTK20.33486006
135MAPKAPK30.32267964
136CDK120.32071403
137CAMK1D0.31904902
138MAPK120.31238634
139MTOR0.29738360
140STK30.28758375

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.00074893
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.50939298
3Nitrogen metabolism_Homo sapiens_hsa009103.21229150
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.84154147
5Tryptophan metabolism_Homo sapiens_hsa003802.82071099
6Arginine biosynthesis_Homo sapiens_hsa002202.75709617
7Fatty acid degradation_Homo sapiens_hsa000712.47191892
8Caffeine metabolism_Homo sapiens_hsa002322.39074167
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.31620832
10Complement and coagulation cascades_Homo sapiens_hsa046102.29174280
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.24921077
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.21403045
13Fat digestion and absorption_Homo sapiens_hsa049752.13187246
14Maturity onset diabetes of the young_Homo sapiens_hsa049502.12522033
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.06891794
16Histidine metabolism_Homo sapiens_hsa003402.02536264
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.01095044
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.98756476
19Other glycan degradation_Homo sapiens_hsa005111.97453606
20Peroxisome_Homo sapiens_hsa041461.90917417
21Drug metabolism - other enzymes_Homo sapiens_hsa009831.87424531
22PPAR signaling pathway_Homo sapiens_hsa033201.86037517
23Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.77512490
24Selenocompound metabolism_Homo sapiens_hsa004501.71745921
25Folate biosynthesis_Homo sapiens_hsa007901.71416990
26Sulfur metabolism_Homo sapiens_hsa009201.69645532
27Bile secretion_Homo sapiens_hsa049761.65936602
28Chemical carcinogenesis_Homo sapiens_hsa052041.65789058
29Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.65657426
30Propanoate metabolism_Homo sapiens_hsa006401.63738425
31Starch and sucrose metabolism_Homo sapiens_hsa005001.62839651
32Butanoate metabolism_Homo sapiens_hsa006501.62420146
33beta-Alanine metabolism_Homo sapiens_hsa004101.59890920
34Steroid hormone biosynthesis_Homo sapiens_hsa001401.54695896
35ABC transporters_Homo sapiens_hsa020101.53363766
36Fatty acid metabolism_Homo sapiens_hsa012121.53170243
37Vitamin digestion and absorption_Homo sapiens_hsa049771.51628744
38Retinol metabolism_Homo sapiens_hsa008301.47011762
39Glycosaminoglycan degradation_Homo sapiens_hsa005311.45151238
40Renin-angiotensin system_Homo sapiens_hsa046141.42515002
41Staphylococcus aureus infection_Homo sapiens_hsa051501.38846640
42Cyanoamino acid metabolism_Homo sapiens_hsa004601.29414112
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.25226951
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.24869861
45Sphingolipid metabolism_Homo sapiens_hsa006001.24666337
46Phenylalanine metabolism_Homo sapiens_hsa003601.24102392
47Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.18761058
48Pyruvate metabolism_Homo sapiens_hsa006201.15403297
49Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.10452416
50Lysine degradation_Homo sapiens_hsa003101.05868790
51Arachidonic acid metabolism_Homo sapiens_hsa005901.02557527
52Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.02145438
53Tyrosine metabolism_Homo sapiens_hsa003501.01743803
54Primary immunodeficiency_Homo sapiens_hsa053400.95183425
55Carbon metabolism_Homo sapiens_hsa012000.93624437
56Cysteine and methionine metabolism_Homo sapiens_hsa002700.90204676
57Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.89859738
58Biosynthesis of amino acids_Homo sapiens_hsa012300.88263564
59Glycerolipid metabolism_Homo sapiens_hsa005610.81835367
60Arginine and proline metabolism_Homo sapiens_hsa003300.81762565
61Fatty acid elongation_Homo sapiens_hsa000620.81263222
62ECM-receptor interaction_Homo sapiens_hsa045120.78367771
63Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.78165871
64Sulfur relay system_Homo sapiens_hsa041220.74345492
65Pertussis_Homo sapiens_hsa051330.72593296
66Pentose phosphate pathway_Homo sapiens_hsa000300.70934235
67Galactose metabolism_Homo sapiens_hsa000520.69968053
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68360072
69Glutathione metabolism_Homo sapiens_hsa004800.66694096
70Lysosome_Homo sapiens_hsa041420.65164543
71One carbon pool by folate_Homo sapiens_hsa006700.64452951
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63272824
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56438980
74Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52581984
75African trypanosomiasis_Homo sapiens_hsa051430.51072691
76Steroid biosynthesis_Homo sapiens_hsa001000.50880346
77TNF signaling pathway_Homo sapiens_hsa046680.48489521
78Insulin resistance_Homo sapiens_hsa049310.48152462
79Focal adhesion_Homo sapiens_hsa045100.44656858
80Graft-versus-host disease_Homo sapiens_hsa053320.44374745
81Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.43936339
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43863927
83Amoebiasis_Homo sapiens_hsa051460.43172013
84Ether lipid metabolism_Homo sapiens_hsa005650.42690456
85Mineral absorption_Homo sapiens_hsa049780.41309141
86Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40488593
87Fructose and mannose metabolism_Homo sapiens_hsa000510.38577185
88AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.36963643
89Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.35766194
90Allograft rejection_Homo sapiens_hsa053300.35061590
91Autoimmune thyroid disease_Homo sapiens_hsa053200.33420566
92Metabolic pathways_Homo sapiens_hsa011000.32208640
93Intestinal immune network for IgA production_Homo sapiens_hsa046720.30976062
94* Protein digestion and absorption_Homo sapiens_hsa049740.30159764
95Fatty acid biosynthesis_Homo sapiens_hsa000610.28389387
96Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.28378862
97Proteoglycans in cancer_Homo sapiens_hsa052050.24799228
98Type I diabetes mellitus_Homo sapiens_hsa049400.24628082
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.24376961
100Malaria_Homo sapiens_hsa051440.22136756
101NF-kappa B signaling pathway_Homo sapiens_hsa040640.21703356
102Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.21010490
103Rheumatoid arthritis_Homo sapiens_hsa053230.20683318
104alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.20592841
105Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.19389895
106Jak-STAT signaling pathway_Homo sapiens_hsa046300.17982898
107Toxoplasmosis_Homo sapiens_hsa051450.17021616
108B cell receptor signaling pathway_Homo sapiens_hsa046620.16798808
109Antigen processing and presentation_Homo sapiens_hsa046120.16176247
110Hepatitis C_Homo sapiens_hsa051600.16095836
111Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.13372264
112Vitamin B6 metabolism_Homo sapiens_hsa007500.12973182
113RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.12291632
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.12058728
115Linoleic acid metabolism_Homo sapiens_hsa005910.08607048
116Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.06638221
117Measles_Homo sapiens_hsa051620.06278324
118Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.04437246
119Thyroid hormone synthesis_Homo sapiens_hsa049180.04413047
120AMPK signaling pathway_Homo sapiens_hsa041520.03534809
121Acute myeloid leukemia_Homo sapiens_hsa052210.02806461
122Leukocyte transendothelial migration_Homo sapiens_hsa046700.02228260
123Prion diseases_Homo sapiens_hsa050200.00959459
124N-Glycan biosynthesis_Homo sapiens_hsa005100.00670343
125Hematopoietic cell lineage_Homo sapiens_hsa046400.00589579
126Small cell lung cancer_Homo sapiens_hsa052220.00159927
127Glucagon signaling pathway_Homo sapiens_hsa04922-0.0002741

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