DPP6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a single-pass type II membrane protein that is a member of the peptidase S9B family of serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Variations in this gene may be associated with susceptibility to amyotrophic lateral sclerosis and with idiopathic ventricular fibrillation. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.23407367
2synaptic vesicle maturation (GO:0016188)6.01791572
3locomotory exploration behavior (GO:0035641)5.77207454
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.54158643
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.49940058
6vocalization behavior (GO:0071625)5.45270070
7synaptic vesicle exocytosis (GO:0016079)5.33362236
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.11439117
9glutamate secretion (GO:0014047)5.05721845
10regulation of synaptic vesicle exocytosis (GO:2000300)5.01254988
11ionotropic glutamate receptor signaling pathway (GO:0035235)4.89720506
12regulation of glutamate receptor signaling pathway (GO:1900449)4.82300528
13neuronal action potential propagation (GO:0019227)4.68820310
14synaptic vesicle docking involved in exocytosis (GO:0016081)4.64707318
15neurotransmitter secretion (GO:0007269)4.63994359
16protein localization to synapse (GO:0035418)4.58891964
17regulation of synaptic vesicle transport (GO:1902803)4.53256248
18exploration behavior (GO:0035640)4.52170826
19neuron cell-cell adhesion (GO:0007158)4.49659160
20gamma-aminobutyric acid transport (GO:0015812)4.41923849
21regulation of neuronal synaptic plasticity (GO:0048168)4.37667210
22regulation of synapse structural plasticity (GO:0051823)4.35963793
23presynaptic membrane assembly (GO:0097105)4.34347341
24synaptic transmission, glutamatergic (GO:0035249)4.31795850
25regulation of long-term neuronal synaptic plasticity (GO:0048169)4.31377930
26glutamate receptor signaling pathway (GO:0007215)4.28683479
27cellular potassium ion homeostasis (GO:0030007)4.25086453
28layer formation in cerebral cortex (GO:0021819)4.16226172
29presynaptic membrane organization (GO:0097090)4.10614181
30proline transport (GO:0015824)4.10509728
31regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.07567537
32neuron-neuron synaptic transmission (GO:0007270)4.07068766
33sodium ion export (GO:0071436)4.03707461
34membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.02812233
35serotonin metabolic process (GO:0042428)4.00942880
36neurotransmitter-gated ion channel clustering (GO:0072578)3.98996489
37long-term memory (GO:0007616)3.95755088
38neurotransmitter transport (GO:0006836)3.79783755
39regulation of excitatory postsynaptic membrane potential (GO:0060079)3.71923189
40positive regulation of synaptic transmission, GABAergic (GO:0032230)3.71872082
41dendritic spine morphogenesis (GO:0060997)3.71085645
42neuromuscular process controlling posture (GO:0050884)3.68826457
43positive regulation of membrane potential (GO:0045838)3.68027211
44positive regulation of synapse maturation (GO:0090129)3.67417864
45primary amino compound metabolic process (GO:1901160)3.67387861
46behavioral response to nicotine (GO:0035095)3.65893739
47cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.63945788
48regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.62536079
49cerebellar Purkinje cell differentiation (GO:0021702)3.60678527
50transmission of nerve impulse (GO:0019226)3.58017754
51regulation of postsynaptic membrane potential (GO:0060078)3.55450309
52neuromuscular process controlling balance (GO:0050885)3.54049994
53activation of protein kinase A activity (GO:0034199)3.52705830
54membrane depolarization during action potential (GO:0086010)3.52177771
55positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.51884901
56regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.51743013
57regulation of neurotransmitter levels (GO:0001505)3.51724521
58glycine transport (GO:0015816)3.51657677
59potassium ion import (GO:0010107)3.50353244
60axon ensheathment in central nervous system (GO:0032291)3.49796372
61central nervous system myelination (GO:0022010)3.49796372
62synaptic vesicle endocytosis (GO:0048488)3.47159409
63gamma-aminobutyric acid signaling pathway (GO:0007214)3.46738707
64regulation of synaptic plasticity (GO:0048167)3.46347723
65cell communication by electrical coupling (GO:0010644)3.43060454
66negative regulation of synaptic transmission, GABAergic (GO:0032229)3.41826439
67neuron recognition (GO:0008038)3.41637212
68prepulse inhibition (GO:0060134)3.40672409
69regulation of neurotransmitter secretion (GO:0046928)3.38989338
70positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.38808592
71startle response (GO:0001964)3.38439435
72regulation of synaptic transmission, glutamatergic (GO:0051966)3.37223908
73positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.33748854
74regulation of vesicle fusion (GO:0031338)3.31947817
75mechanosensory behavior (GO:0007638)3.31158617
76potassium ion homeostasis (GO:0055075)3.29850292
77G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.29155370
78long-term synaptic potentiation (GO:0060291)3.27995081
79dendrite morphogenesis (GO:0048813)3.27715376
80innervation (GO:0060384)3.27091351
81membrane depolarization (GO:0051899)3.25615716
82regulation of dendritic spine morphogenesis (GO:0061001)3.22674446
83response to auditory stimulus (GO:0010996)3.22013288
84regulation of synapse maturation (GO:0090128)3.20821426
85auditory behavior (GO:0031223)3.20216074
86neuromuscular synaptic transmission (GO:0007274)3.19980836
87regulation of neurotransmitter transport (GO:0051588)3.18401807
88membrane hyperpolarization (GO:0060081)3.18318062
89postsynaptic membrane organization (GO:0001941)3.14418214
90negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.14111482
91axonal fasciculation (GO:0007413)3.13972405
92vesicle transport along microtubule (GO:0047496)3.13044086
93neuronal ion channel clustering (GO:0045161)3.11538792
94mating behavior (GO:0007617)3.10841501
95cellular sodium ion homeostasis (GO:0006883)3.09112748
96cell migration in hindbrain (GO:0021535)3.07702271
97synapse assembly (GO:0007416)3.07340346
98learning (GO:0007612)3.07222045
99regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.05945520
100response to pheromone (GO:0019236)3.05480162
101synaptic transmission (GO:0007268)3.05389864
102regulation of calcium ion-dependent exocytosis (GO:0017158)3.05381747
103neuromuscular process (GO:0050905)3.04557075
104regulation of neurotransmitter uptake (GO:0051580)3.04145313
105negative regulation of cytosolic calcium ion concentration (GO:0051481)3.01810117
106L-amino acid import (GO:0043092)3.01149628
107behavioral defense response (GO:0002209)3.00603705
108behavioral fear response (GO:0001662)3.00603705
109intraspecies interaction between organisms (GO:0051703)3.00218640
110social behavior (GO:0035176)3.00218640
111regulation of synaptic transmission (GO:0050804)2.99931568
112positive regulation of synaptic transmission (GO:0050806)2.98606862
113regulation of synaptic transmission, GABAergic (GO:0032228)2.96383482
114positive regulation of neurotransmitter transport (GO:0051590)2.95651959
115cerebellar granule cell differentiation (GO:0021707)2.95454569
116adult walking behavior (GO:0007628)2.95218239
117negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.94112369
118neurotransmitter uptake (GO:0001504)2.92267880
119cell differentiation in hindbrain (GO:0021533)2.90769349
120regulation of female receptivity (GO:0045924)2.89691374
121detection of calcium ion (GO:0005513)2.87689985
122regulation of voltage-gated calcium channel activity (GO:1901385)2.86541385
123positive regulation of dendritic spine development (GO:0060999)2.85717984
124* neuronal action potential (GO:0019228)2.82440656
125response to amphetamine (GO:0001975)2.78359711
126cellular potassium ion transport (GO:0071804)2.77400076
127potassium ion transmembrane transport (GO:0071805)2.77400076
128fear response (GO:0042596)2.74757858
129adult behavior (GO:0030534)2.74325954
130multicellular organismal signaling (GO:0035637)2.73996428
131calcium ion-dependent exocytosis (GO:0017156)2.73583196
132positive regulation of neurotransmitter secretion (GO:0001956)2.69196487

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.10168390
2GBX2_23144817_ChIP-Seq_PC3_Human3.44605236
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.13445525
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.11612262
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.07682196
6* REST_21632747_ChIP-Seq_MESCs_Mouse2.80207906
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.78210263
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.78210263
9* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.67913084
10* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.58919742
11DROSHA_22980978_ChIP-Seq_HELA_Human2.57199666
12RARB_27405468_Chip-Seq_BRAIN_Mouse2.56450285
13* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.55590697
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.55309046
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.54768169
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.47917429
17* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.46316820
18* REST_18959480_ChIP-ChIP_MESCs_Mouse2.30694850
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.30055995
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.29159548
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.27667625
22IKZF1_21737484_ChIP-ChIP_HCT116_Human2.26108027
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.20649835
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.16776767
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.06828273
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.04221501
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.01022624
28EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.98218090
29* NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.88898997
30AR_21572438_ChIP-Seq_LNCaP_Human1.86611714
31* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.66557513
32ERG_21242973_ChIP-ChIP_JURKAT_Human1.63457980
33* SMAD4_21799915_ChIP-Seq_A2780_Human1.63070641
34* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.62979750
35POU3F2_20337985_ChIP-ChIP_501MEL_Human1.52634408
36TAF15_26573619_Chip-Seq_HEK293_Human1.50449039
37* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46768571
38VDR_22108803_ChIP-Seq_LS180_Human1.40627622
39* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.38923974
40ZNF274_21170338_ChIP-Seq_K562_Hela1.36903191
41CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.35965373
42* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.34376578
43RING1B_27294783_Chip-Seq_ESCs_Mouse1.33712479
44HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.32484973
45PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.31748597
46SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29912387
47* SOX2_21211035_ChIP-Seq_LN229_Gbm1.29766323
48FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.27925544
49FUS_26573619_Chip-Seq_HEK293_Human1.27665017
50DNAJC2_21179169_ChIP-ChIP_NT2_Human1.26507561
51SMAD_19615063_ChIP-ChIP_OVARY_Human1.26190594
52NR3C1_23031785_ChIP-Seq_PC12_Mouse1.25360504
53* AR_19668381_ChIP-Seq_PC3_Human1.24402058
54ZFP57_27257070_Chip-Seq_ESCs_Mouse1.24128955
55RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.23410371
56* P300_19829295_ChIP-Seq_ESCs_Human1.22790541
57* STAT3_23295773_ChIP-Seq_U87_Human1.22521263
58* AR_25329375_ChIP-Seq_VCAP_Human1.21114094
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.19752411
60* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19141150
61CBX2_27304074_Chip-Seq_ESCs_Mouse1.16548527
62RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16141754
63BMI1_23680149_ChIP-Seq_NPCS_Mouse1.15127276
64* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.14862304
65KDM2B_26808549_Chip-Seq_K562_Human1.11642339
66* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10280251
67BCAT_22108803_ChIP-Seq_LS180_Human1.10177539
68RING1B_27294783_Chip-Seq_NPCs_Mouse1.09636792
69GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07841068
70IGF1R_20145208_ChIP-Seq_DFB_Human1.07244662
71* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07052878
72RNF2_27304074_Chip-Seq_NSC_Mouse1.07020032
73* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06086656
74* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.05473232
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.05052736
76TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04904919
77* TCF4_23295773_ChIP-Seq_U87_Human1.04848515
78CDX2_19796622_ChIP-Seq_MESCs_Mouse1.04803963
79P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04773254
80ZFP281_18757296_ChIP-ChIP_E14_Mouse1.04516505
81NANOG_18555785_Chip-Seq_ESCs_Mouse1.03620833
82* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03487738
83ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.02881361
84MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02770940
85* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02316775
86* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02135233
87RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02089863
88MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.01167570
89ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01029464
90ARNT_22903824_ChIP-Seq_MCF-7_Human1.00809145
91TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00294004
92AHR_22903824_ChIP-Seq_MCF-7_Human0.99784022
93ER_23166858_ChIP-Seq_MCF-7_Human0.99564702
94IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98602027
95CBP_20019798_ChIP-Seq_JUKART_Human0.98602027
96WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.97164489
97CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.96959055
98KDM2B_26808549_Chip-Seq_REH_Human0.96634118
99SMAD3_21741376_ChIP-Seq_ESCs_Human0.96316623
100* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95307525
101AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.95074840
102SMAD4_21741376_ChIP-Seq_EPCs_Human0.94894412
103FLI1_21867929_ChIP-Seq_TH2_Mouse0.94347632
104SMAD4_21741376_ChIP-Seq_HESCs_Human0.94331045
105* EWS_26573619_Chip-Seq_HEK293_Human0.93583565
106NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93090455
107P53_22387025_ChIP-Seq_ESCs_Mouse0.93010454
108KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.91832304
109RUNX2_22187159_ChIP-Seq_PCA_Human0.91739612
110JUN_21703547_ChIP-Seq_K562_Human0.91589001
111* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90846990
112TAL1_26923725_Chip-Seq_HPCs_Mouse0.90655908
113CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90071228
114SMAD3_21741376_ChIP-Seq_HESCs_Human0.90051685
115FLI1_27457419_Chip-Seq_LIVER_Mouse0.89495114
116TP53_16413492_ChIP-PET_HCT116_Human0.88046909
117* PRDM14_20953172_ChIP-Seq_ESCs_Human0.86905126
118TET1_21490601_ChIP-Seq_MESCs_Mouse0.86082454
119CTCF_27219007_Chip-Seq_Bcells_Human0.85799428
120TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.84677412
121* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84623484
122TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.83912174
123TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83892710
124POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.83892710
125UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.81373873

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.39395398
2MP0003880_abnormal_central_pattern4.64128832
3MP0003635_abnormal_synaptic_transmissio4.15455355
4MP0004270_analgesia3.59930093
5MP0009745_abnormal_behavioral_response3.40439669
6MP0001968_abnormal_touch/_nociception3.34901376
7MP0009046_muscle_twitch3.33163514
8MP0002063_abnormal_learning/memory/cond3.27089059
9MP0002064_seizures3.17127245
10MP0005423_abnormal_somatic_nervous2.95591329
11MP0002734_abnormal_mechanical_nocicepti2.81196217
12MP0002735_abnormal_chemical_nociception2.80980604
13MP0002572_abnormal_emotion/affect_behav2.75737102
14MP0002822_catalepsy2.73381492
15MP0002272_abnormal_nervous_system2.72156943
16MP0002736_abnormal_nociception_after2.63458560
17MP0001486_abnormal_startle_reflex2.53460221
18MP0001501_abnormal_sleep_pattern2.35261333
19MP0002733_abnormal_thermal_nociception2.26411823
20MP0001970_abnormal_pain_threshold2.16615570
21MP0001440_abnormal_grooming_behavior2.13800352
22MP0002067_abnormal_sensory_capabilities2.09709614
23MP0004858_abnormal_nervous_system2.06025200
24MP0008569_lethality_at_weaning2.04566475
25MP0006276_abnormal_autonomic_nervous2.01546053
26MP0002184_abnormal_innervation1.95824861
27MP0008877_abnormal_DNA_methylation1.92714917
28MP0002909_abnormal_adrenal_gland1.82565645
29MP0004811_abnormal_neuron_physiology1.77940800
30MP0002557_abnormal_social/conspecific_i1.76131957
31MP0005646_abnormal_pituitary_gland1.71315320
32MP0003329_amyloid_beta_deposits1.70914250
33MP0004924_abnormal_behavior1.70910000
34MP0005386_behavior/neurological_phenoty1.70910000
35MP0000778_abnormal_nervous_system1.68970666
36MP0009780_abnormal_chondrocyte_physiolo1.62381653
37MP0000955_abnormal_spinal_cord1.61893732
38MP0001984_abnormal_olfaction1.57900273
39MP0005645_abnormal_hypothalamus_physiol1.54014633
40MP0003787_abnormal_imprinting1.48842517
41MP0003879_abnormal_hair_cell1.46602382
42MP0002066_abnormal_motor_capabilities/c1.43931624
43MP0002882_abnormal_neuron_morphology1.43884549
44MP0003122_maternal_imprinting1.40280886
45MP0004885_abnormal_endolymph1.39567926
46MP0001502_abnormal_circadian_rhythm1.36855219
47MP0004142_abnormal_muscle_tone1.34532764
48MP0003633_abnormal_nervous_system1.31386173
49MP0001986_abnormal_taste_sensitivity1.26429761
50MP0002876_abnormal_thyroid_physiology1.21681162
51MP0001529_abnormal_vocalization1.20966750
52MP0001905_abnormal_dopamine_level1.20300123
53MP0002837_dystrophic_cardiac_calcinosis1.18309230
54MP0003631_nervous_system_phenotype1.11624052
55MP0002152_abnormal_brain_morphology1.07988244
56MP0001188_hyperpigmentation1.05400580
57MP0000569_abnormal_digit_pigmentation1.04039726
58MP0006292_abnormal_olfactory_placode1.03972207
59MP0002229_neurodegeneration1.03802055
60MP0010386_abnormal_urinary_bladder1.03189627
61MP0008872_abnormal_physiological_respon1.01661436
62MP0003123_paternal_imprinting1.01587795
63MP0003121_genomic_imprinting1.01472420
64MP0000751_myopathy1.00081590
65MP0004145_abnormal_muscle_electrophysio0.99757936
66MP0005551_abnormal_eye_electrophysiolog0.98021631
67MP0001177_atelectasis0.97063915
68MP0004133_heterotaxia0.94845058
69MP0002069_abnormal_eating/drinking_beha0.94798841
70MP0005253_abnormal_eye_physiology0.93620915
71MP0003195_calcinosis0.92475147
72MP0000026_abnormal_inner_ear0.90672821
73MP0003690_abnormal_glial_cell0.89995818
74MP0004742_abnormal_vestibular_system0.88695067
75MP0003136_yellow_coat_color0.88046988
76MP0003634_abnormal_glial_cell0.86181449
77MP0002653_abnormal_ependyma_morphology0.85332623
78MP0008874_decreased_physiological_sensi0.84975560
79MP0003283_abnormal_digestive_organ0.84662525
80MP0008961_abnormal_basal_metabolism0.83885180
81MP0003632_abnormal_nervous_system0.83173446
82MP0004085_abnormal_heartbeat0.81641970
83MP0005394_taste/olfaction_phenotype0.80932037
84MP0005499_abnormal_olfactory_system0.80932037
85MP0005535_abnormal_body_temperature0.80135213
86MP0002160_abnormal_reproductive_system0.80070574
87MP0002638_abnormal_pupillary_reflex0.79046937
88MP0002102_abnormal_ear_morphology0.78094070
89MP0003075_altered_response_to0.78064374
90MP0002752_abnormal_somatic_nervous0.78010609
91MP0001963_abnormal_hearing_physiology0.77814793
92MP0000920_abnormal_myelination0.77604819
93MP0000013_abnormal_adipose_tissue0.77346575
94MP0002928_abnormal_bile_duct0.75703450
95MP0000631_abnormal_neuroendocrine_gland0.74578871
96MP0002090_abnormal_vision0.74067349
97MP0003938_abnormal_ear_development0.73127399
98MP0004130_abnormal_muscle_cell0.72365183
99MP0001299_abnormal_eye_distance/0.72317242
100MP0000604_amyloidosis0.72115565
101MP0003137_abnormal_impulse_conducting0.70621541
102MP0003011_delayed_dark_adaptation0.68323954
103MP0003119_abnormal_digestive_system0.67516472
104MP0004147_increased_porphyrin_level0.66347778
105MP0004215_abnormal_myocardial_fiber0.66126475
106MP0005389_reproductive_system_phenotype0.61572604
107MP0000639_abnormal_adrenal_gland0.60850812
108MP0001944_abnormal_pancreas_morphology0.60566336
109MP0005167_abnormal_blood-brain_barrier0.60047158
110MP0001664_abnormal_digestion0.59712292
111MP0003172_abnormal_lysosome_physiology0.57429483
112MP0004233_abnormal_muscle_weight0.56897383
113MP0005623_abnormal_meninges_morphology0.56710785
114MP0001485_abnormal_pinna_reflex0.56543699
115MP0001943_abnormal_respiration0.55778357
116MP0010769_abnormal_survival0.54863271
117MP0004484_altered_response_of0.53291561
118MP0003861_abnormal_nervous_system0.53278272
119MP0002082_postnatal_lethality0.52814763
120MP0010770_preweaning_lethality0.52814763
121MP0004043_abnormal_pH_regulation0.52638866
122MP0006072_abnormal_retinal_apoptosis0.51950445
123MP0005409_darkened_coat_color0.51497519
124MP0010768_mortality/aging0.51452399

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.44932971
2Myokymia (HP:0002411)7.16192212
3Focal seizures (HP:0007359)5.74292600
4Visual hallucinations (HP:0002367)5.25192687
5Progressive cerebellar ataxia (HP:0002073)4.89580426
6Action tremor (HP:0002345)4.66443441
7Febrile seizures (HP:0002373)4.62149977
8Atonic seizures (HP:0010819)4.60307594
9Epileptic encephalopathy (HP:0200134)4.51451985
10Absence seizures (HP:0002121)4.16323968
11Supranuclear gaze palsy (HP:0000605)3.86170176
12Generalized tonic-clonic seizures (HP:0002069)3.83540801
13Dialeptic seizures (HP:0011146)3.81914439
14Ankle clonus (HP:0011448)3.64310844
15Gaze-evoked nystagmus (HP:0000640)3.40543682
16Depression (HP:0000716)3.39808075
17Dysdiadochokinesis (HP:0002075)3.32602449
18Impaired vibration sensation in the lower limbs (HP:0002166)3.31955839
19Broad-based gait (HP:0002136)3.26551534
20Abnormal eating behavior (HP:0100738)3.19037451
21Mutism (HP:0002300)3.18919281
22Abnormality of the lower motor neuron (HP:0002366)3.18046956
23Truncal ataxia (HP:0002078)3.16920859
24Poor eye contact (HP:0000817)3.16726748
25Dysmetria (HP:0001310)3.16159529
26Postural instability (HP:0002172)3.13279148
27Urinary bladder sphincter dysfunction (HP:0002839)3.09885395
28Anxiety (HP:0000739)3.02404282
29Scanning speech (HP:0002168)3.01819654
30Papilledema (HP:0001085)2.96962859
31Impaired social interactions (HP:0000735)2.95246874
32Abnormal social behavior (HP:0012433)2.95246874
33Genetic anticipation (HP:0003743)2.93003309
34Impaired smooth pursuit (HP:0007772)2.84217698
35Urinary urgency (HP:0000012)2.78927794
36Spastic gait (HP:0002064)2.72266723
37Hemiplegia (HP:0002301)2.70942095
38Progressive inability to walk (HP:0002505)2.70872856
39Torticollis (HP:0000473)2.69259297
40Increased circulating renin level (HP:0000848)2.67814507
41Amblyopia (HP:0000646)2.66917383
42Limb dystonia (HP:0002451)2.65204333
43Hemiparesis (HP:0001269)2.63669532
44Intention tremor (HP:0002080)2.61155709
45Pheochromocytoma (HP:0002666)2.60869569
46Hyperventilation (HP:0002883)2.55868945
47Abnormality of ocular smooth pursuit (HP:0000617)2.55790501
48Bradykinesia (HP:0002067)2.54336105
49Drooling (HP:0002307)2.50099456
50Excessive salivation (HP:0003781)2.50099456
51Focal dystonia (HP:0004373)2.48199114
52Pancreatic fibrosis (HP:0100732)2.48009955
53Insidious onset (HP:0003587)2.45287449
54Termporal pattern (HP:0011008)2.45287449
55Diplopia (HP:0000651)2.43852946
56Abnormality of binocular vision (HP:0011514)2.43852946
57Congenital stationary night blindness (HP:0007642)2.41202811
58True hermaphroditism (HP:0010459)2.39156904
59Fetal akinesia sequence (HP:0001989)2.38766954
60Pancreatic cysts (HP:0001737)2.36148908
61Status epilepticus (HP:0002133)2.33365874
62Dysmetric saccades (HP:0000641)2.32140597
63Stereotypic behavior (HP:0000733)2.29383339
64Gait imbalance (HP:0002141)2.28540907
65Polyphagia (HP:0002591)2.28225483
66Neuroendocrine neoplasm (HP:0100634)2.25457825
67Epileptiform EEG discharges (HP:0011182)2.24071795
68Abnormality of the corticospinal tract (HP:0002492)2.24026175
69Annular pancreas (HP:0001734)2.23799145
70Lower limb muscle weakness (HP:0007340)2.21371895
71Failure to thrive in infancy (HP:0001531)2.21341345
72Craniofacial dystonia (HP:0012179)2.20846999
73Neurofibrillary tangles (HP:0002185)2.20608358
74Impaired vibratory sensation (HP:0002495)2.18511033
75Agitation (HP:0000713)2.17919540
76Medial flaring of the eyebrow (HP:0010747)2.16089705
77Nephronophthisis (HP:0000090)2.15924282
78EEG with generalized epileptiform discharges (HP:0011198)2.14935574
79Insomnia (HP:0100785)2.14327859
80Pointed chin (HP:0000307)2.12695212
81Molar tooth sign on MRI (HP:0002419)2.12291879
82Abnormality of midbrain morphology (HP:0002418)2.12291879
83Abolished electroretinogram (ERG) (HP:0000550)2.11257460
84Decreased central vision (HP:0007663)2.10998984
85Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.10398634
86Degeneration of the lateral corticospinal tracts (HP:0002314)2.10398634
87Megalencephaly (HP:0001355)2.08575061
88Polydipsia (HP:0001959)2.07351000
89Abnormal drinking behavior (HP:0030082)2.07351000
90Cerebral inclusion bodies (HP:0100314)2.06212177
91Abnormality of saccadic eye movements (HP:0000570)2.04709606
92Akinesia (HP:0002304)2.04252872
93Hypsarrhythmia (HP:0002521)2.03425534
94Gait ataxia (HP:0002066)2.03242326
95Clonus (HP:0002169)2.02697151
96Absent speech (HP:0001344)2.00965063
97Neuronal loss in central nervous system (HP:0002529)2.00889548
98Incomplete penetrance (HP:0003829)2.00373662
99Congenital sensorineural hearing impairment (HP:0008527)1.97783039
100Confusion (HP:0001289)1.96670213
101Type II lissencephaly (HP:0007260)1.96491701
102Abnormal EKG (HP:0003115)1.96045349
103Morphological abnormality of the pyramidal tract (HP:0002062)1.96028090
104Optic nerve hypoplasia (HP:0000609)1.95139571
105Hypomagnesemia (HP:0002917)1.92574805
106Postural tremor (HP:0002174)1.91446089
107Sleep apnea (HP:0010535)1.90182938
108Inability to walk (HP:0002540)1.89843275
109Oligodactyly (hands) (HP:0001180)1.89364606
110Rigidity (HP:0002063)1.88913208
111Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.88776185
112Generalized myoclonic seizures (HP:0002123)1.88156992
113Hyperinsulinemic hypoglycemia (HP:0000825)1.87290747
114Hypoventilation (HP:0002791)1.87128586
115Bundle branch block (HP:0011710)1.86991482
116Psychosis (HP:0000709)1.86178863
117Blue irides (HP:0000635)1.84257868
118Cerebral hypomyelination (HP:0006808)1.83910870
119Amyotrophic lateral sclerosis (HP:0007354)1.82773864
120Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.82391752
121Tetraplegia (HP:0002445)1.80354174
122Neoplasm of the peripheral nervous system (HP:0100007)1.80230303
123Pendular nystagmus (HP:0012043)1.77492303
124Hypoglycemic seizures (HP:0002173)1.77113057
125Lower limb asymmetry (HP:0100559)1.77099684
126Protruding tongue (HP:0010808)1.76980535
127Goiter (HP:0000853)1.76893349
128Cystic liver disease (HP:0006706)1.75971314
129Congenital primary aphakia (HP:0007707)1.75415420
130Dyskinesia (HP:0100660)1.73602821
131Specific learning disability (HP:0001328)1.73351228
132Genital tract atresia (HP:0001827)1.72875232
133Retinal dysplasia (HP:0007973)1.72036641
134Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.71818716
135Abnormality of the renal medulla (HP:0100957)1.71341261
136Prolonged QT interval (HP:0001657)1.69507882
137Vaginal atresia (HP:0000148)1.66605279
138Metabolic alkalosis (HP:0200114)1.65469606

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.80598539
2MAP3K93.84836931
3EPHA43.67069285
4MARK13.24898974
5FRK3.18015620
6MAP3K43.00271497
7MINK12.89262479
8MAP2K72.44577076
9PAK62.30975227
10NTRK22.28643527
11KSR22.19700965
12DAPK22.19620518
13MAP3K122.07368454
14NTRK11.97348931
15PRKD31.93952933
16CAMKK11.93090097
17MAP2K41.92872809
18ADRBK21.73974938
19RIPK41.68268505
20STK381.60392205
21GRK11.59487864
22TNIK1.58257608
23CDK51.55698732
24KSR11.51121211
25CASK1.49734899
26MAPK131.39011376
27ARAF1.37982094
28GRK51.37682641
29PRPF4B1.30821358
30CAMKK21.28632342
31PRKCG1.26093484
32DAPK11.25791655
33MAP3K21.25457577
34FGFR21.21816332
35FES1.21764561
36SIK21.21443510
37INSRR1.19756430
38UHMK11.18164780
39PHKG11.17214312
40PHKG21.17214312
41LMTK21.17080228
42SGK4941.16395296
43SGK2231.16395296
44PLK21.13809958
45CDK191.12160440
46MAP3K131.09314968
47SGK21.07550187
48BMPR1B1.06016067
49PNCK1.04048481
50TYRO31.03143529
51PKN11.02500319
52CAMK11.01784914
53PINK11.01065334
54LATS21.00038842
55CAMK2A0.97766287
56MAP4K20.97396968
57PRKCH0.96712239
58RET0.95916876
59SGK30.92700689
60CDK180.91411213
61CDK150.90097730
62CDK140.88065587
63DYRK20.83427078
64CAMK2B0.80874081
65MARK20.79398723
66STK110.79281820
67ALK0.79187837
68TAOK10.78628971
69CDK11A0.77664194
70WNK40.75908007
71TAOK30.73968262
72TNK20.73393761
73WNK10.72492608
74STK390.72184832
75PAK30.70491437
76RAF10.69002546
77DYRK1A0.67826271
78MAPK150.67382316
79SGK10.67361448
80CSNK1G30.67256782
81MAP3K10.64470299
82CSNK1G20.63593952
83PTK2B0.62602614
84CSNK1G10.62042180
85CDC42BPA0.61555791
86PDK10.60830564
87SCYL20.60736890
88RIPK10.60327881
89MAP2K60.60200508
90CAMK2G0.57398596
91TLK10.57386522
92PRKACA0.56898406
93NEK60.53839569
94CAMK2D0.53755636
95NEK10.53207374
96PDPK10.52838237
97OXSR10.52795583
98RPS6KA30.52413796
99BMPR20.52184810
100FER0.51905307
101ADRBK10.51898333
102CAMK1G0.51637053
103CSNK1A10.51501844
104PRKCZ0.50830439
105ERBB20.50763873
106PRKG10.49532314
107PRKCA0.49395247
108ACVR1B0.49193799
109MAPK100.47979493
110CAMK40.47938671
111RPS6KA20.46646365
112PRKCE0.46065360
113FYN0.44565167
114BRSK10.43787020
115MAP3K70.43567319
116CDK30.43542988
117CSNK1D0.43502150
118WNK30.42093418
119LIMK10.40891462
120MAP2K10.40619669
121AKT30.40262567
122ZAK0.40205682
123BRAF0.39037930
124MAPK120.38116451
125CSNK1A1L0.36789038
126NUAK10.35724853
127ROCK20.35672476
128PRKCB0.33583929
129MAPKAPK50.32324477
130SIK30.30688884
131ERBB30.30665553
132PRKACG0.28467107
133ROCK10.27811682
134PRKD20.27646105
135CSNK1E0.26744773

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.91567712
2Synaptic vesicle cycle_Homo sapiens_hsa047213.41164041
3GABAergic synapse_Homo sapiens_hsa047272.83406181
4Olfactory transduction_Homo sapiens_hsa047402.73460074
5Circadian entrainment_Homo sapiens_hsa047132.70214155
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.67724364
7Glutamatergic synapse_Homo sapiens_hsa047242.59602873
8Long-term potentiation_Homo sapiens_hsa047202.57995580
9Morphine addiction_Homo sapiens_hsa050322.51553794
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.37284870
11Amphetamine addiction_Homo sapiens_hsa050312.36671589
12Maturity onset diabetes of the young_Homo sapiens_hsa049502.19314446
13Dopaminergic synapse_Homo sapiens_hsa047282.13812388
14Salivary secretion_Homo sapiens_hsa049702.13055138
15Insulin secretion_Homo sapiens_hsa049112.04273410
16Taste transduction_Homo sapiens_hsa047421.90552387
17Cholinergic synapse_Homo sapiens_hsa047251.90454272
18Gastric acid secretion_Homo sapiens_hsa049711.85419531
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.80465065
20Long-term depression_Homo sapiens_hsa047301.73362422
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.66247616
22Cocaine addiction_Homo sapiens_hsa050301.65919109
23Serotonergic synapse_Homo sapiens_hsa047261.64608710
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.62388848
25Oxytocin signaling pathway_Homo sapiens_hsa049211.59077957
26Calcium signaling pathway_Homo sapiens_hsa040201.57715219
27Renin secretion_Homo sapiens_hsa049241.55485479
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.52191602
29Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.45680127
30GnRH signaling pathway_Homo sapiens_hsa049121.45012252
31Collecting duct acid secretion_Homo sapiens_hsa049661.33671093
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.33523225
33Gap junction_Homo sapiens_hsa045401.31617696
34cAMP signaling pathway_Homo sapiens_hsa040241.28029194
35Type II diabetes mellitus_Homo sapiens_hsa049301.23444335
36Phosphatidylinositol signaling system_Homo sapiens_hsa040701.19852794
37Oxidative phosphorylation_Homo sapiens_hsa001901.14026517
38Estrogen signaling pathway_Homo sapiens_hsa049151.11617814
39Butanoate metabolism_Homo sapiens_hsa006501.10278131
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08666950
41Glioma_Homo sapiens_hsa052141.05016032
42Axon guidance_Homo sapiens_hsa043601.04250759
43Nitrogen metabolism_Homo sapiens_hsa009101.02764397
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.01870723
45Cardiac muscle contraction_Homo sapiens_hsa042600.98786363
46ErbB signaling pathway_Homo sapiens_hsa040120.97065843
47Melanogenesis_Homo sapiens_hsa049160.96620657
48cGMP-PKG signaling pathway_Homo sapiens_hsa040220.94796171
49Alzheimers disease_Homo sapiens_hsa050100.89612218
50Pancreatic secretion_Homo sapiens_hsa049720.88941308
51Vascular smooth muscle contraction_Homo sapiens_hsa042700.87566047
52Phospholipase D signaling pathway_Homo sapiens_hsa040720.86554944
53Vibrio cholerae infection_Homo sapiens_hsa051100.86320233
54Oocyte meiosis_Homo sapiens_hsa041140.84698649
55Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.84115750
56Dorso-ventral axis formation_Homo sapiens_hsa043200.83411113
57Thyroid hormone synthesis_Homo sapiens_hsa049180.82234097
58Parkinsons disease_Homo sapiens_hsa050120.81541921
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81435070
60Linoleic acid metabolism_Homo sapiens_hsa005910.80692692
61Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.80202097
62Phototransduction_Homo sapiens_hsa047440.77591181
63alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.72927535
64Choline metabolism in cancer_Homo sapiens_hsa052310.71701590
65Dilated cardiomyopathy_Homo sapiens_hsa054140.71610115
66Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.70670657
67Ether lipid metabolism_Homo sapiens_hsa005650.70050338
68MAPK signaling pathway_Homo sapiens_hsa040100.69846347
69Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67893555
70Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67468434
71Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.66647763
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64660323
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.64182435
74Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61298466
75Type I diabetes mellitus_Homo sapiens_hsa049400.60520955
76Bile secretion_Homo sapiens_hsa049760.57756056
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57535821
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55612454
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55508209
80Inositol phosphate metabolism_Homo sapiens_hsa005620.54599371
81Mineral absorption_Homo sapiens_hsa049780.54537382
82VEGF signaling pathway_Homo sapiens_hsa043700.54525257
83beta-Alanine metabolism_Homo sapiens_hsa004100.54203903
84Rap1 signaling pathway_Homo sapiens_hsa040150.53988051
85Tryptophan metabolism_Homo sapiens_hsa003800.53384057
86Ras signaling pathway_Homo sapiens_hsa040140.53234674
87Alcoholism_Homo sapiens_hsa050340.51870112
88Endocytosis_Homo sapiens_hsa041440.51734669
89mTOR signaling pathway_Homo sapiens_hsa041500.51625989
90Glucagon signaling pathway_Homo sapiens_hsa049220.50637054
91Vitamin B6 metabolism_Homo sapiens_hsa007500.50137692
92Regulation of autophagy_Homo sapiens_hsa041400.49967303
93Circadian rhythm_Homo sapiens_hsa047100.48662814
94Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48501376
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.47883240
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47589175
97Histidine metabolism_Homo sapiens_hsa003400.47174720
98Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46023596
99Endometrial cancer_Homo sapiens_hsa052130.45780914
100ABC transporters_Homo sapiens_hsa020100.43102920
101Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.42752939
102Prion diseases_Homo sapiens_hsa050200.41461806
103Non-small cell lung cancer_Homo sapiens_hsa052230.39513264
104SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39255935
105Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38862203
106Insulin signaling pathway_Homo sapiens_hsa049100.38544602
107Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37975991
108Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37791379
109Ovarian steroidogenesis_Homo sapiens_hsa049130.36775582
110Huntingtons disease_Homo sapiens_hsa050160.35606624
111Wnt signaling pathway_Homo sapiens_hsa043100.35203208
112Renal cell carcinoma_Homo sapiens_hsa052110.33370520
113Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33134371
114Chemokine signaling pathway_Homo sapiens_hsa040620.31696555
115Glycerophospholipid metabolism_Homo sapiens_hsa005640.31596687
116Protein export_Homo sapiens_hsa030600.31290030
117Hedgehog signaling pathway_Homo sapiens_hsa043400.30891260
118Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.30093424
119Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.28963653
120Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.27834086
121Glycerolipid metabolism_Homo sapiens_hsa005610.27403132
122African trypanosomiasis_Homo sapiens_hsa051430.26260801
123Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.26199031
124Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.25709765
125Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.24835095
126Chemical carcinogenesis_Homo sapiens_hsa052040.23449619
127Prolactin signaling pathway_Homo sapiens_hsa049170.23129085
128Fatty acid biosynthesis_Homo sapiens_hsa000610.23042864

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