DPP8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the peptidase S9B family, a small family of dipeptidyl peptidases that are able to cleave peptide substrates at a prolyl bond. The encoded protein shares similarity with dipeptidyl peptidase IV in that it is ubiquitously expressed, and hydrolyzes the same substrates. These similarities suggest that, like dipeptidyl peptidase IV, this protein may play a role in T-cell activation and immune function. Alternatively spliced transcript variants encoding different isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1imidazole-containing compound metabolic process (GO:0052803)7.01587176
2regulation of T cell tolerance induction (GO:0002664)6.16350312
3regulation of tolerance induction (GO:0002643)5.26291563
4positive regulation of mast cell activation involved in immune response (GO:0033008)4.85037933
5positive regulation of mast cell degranulation (GO:0043306)4.85037933
6positive regulation of mast cell activation (GO:0033005)4.38068065
7synaptic vesicle maturation (GO:0016188)4.34090164
8locomotory exploration behavior (GO:0035641)4.27535465
9regulation of T cell cytokine production (GO:0002724)4.08130233
10interleukin-6-mediated signaling pathway (GO:0070102)3.89940790
11sodium ion export (GO:0071436)3.86100027
12positive regulation of leukocyte degranulation (GO:0043302)3.84012232
13regulation of relaxation of muscle (GO:1901077)3.74539357
14catecholamine biosynthetic process (GO:0042423)3.70294990
15catechol-containing compound biosynthetic process (GO:0009713)3.70294990
16cellular response to ethanol (GO:0071361)3.64626942
17phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.64509018
18positive regulation of granulocyte differentiation (GO:0030854)3.63526636
19regulation of mast cell activation involved in immune response (GO:0033006)3.62950389
20regulation of short-term neuronal synaptic plasticity (GO:0048172)3.57724379
21regulation of ARF protein signal transduction (GO:0032012)3.55452102
22positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.54906375
23activation of protein kinase A activity (GO:0034199)3.43106278
24tachykinin receptor signaling pathway (GO:0007217)3.38212770
25cytoskeletal anchoring at plasma membrane (GO:0007016)3.35556022
26synaptic vesicle docking involved in exocytosis (GO:0016081)3.30509758
27relaxation of cardiac muscle (GO:0055119)3.29815818
28positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.28072286
29layer formation in cerebral cortex (GO:0021819)3.27036741
30cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.26205921
31cellular potassium ion homeostasis (GO:0030007)3.24143245
32establishment of nucleus localization (GO:0040023)3.24006651
33negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.18814191
34negative regulation of T-helper cell differentiation (GO:0045623)3.18814191
35regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.17331722
36positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.11768853
37angiotensin maturation (GO:0002003)3.06974578
38regulation of mast cell activation (GO:0033003)3.06773970
39regulation of synapse structural plasticity (GO:0051823)3.03694616
40plasma membrane repair (GO:0001778)3.02691045
41glutamate secretion (GO:0014047)3.00456428
42cell communication by electrical coupling (GO:0010644)2.99691390
43positive regulation of regulated secretory pathway (GO:1903307)2.98908628
44potassium ion import (GO:0010107)2.96934816
45regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.95625047
46positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.95213917
47negative regulation of neurotransmitter transport (GO:0051589)2.92516268
48regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.90718697
49protein localization to endosome (GO:0036010)2.87515435
50definitive hemopoiesis (GO:0060216)2.86693100
51protein targeting to Golgi (GO:0000042)2.86392539
52relaxation of muscle (GO:0090075)2.84940779
53retrograde transport, vesicle recycling within Golgi (GO:0000301)2.84900404
54establishment of protein localization to Golgi (GO:0072600)2.84133754
55monoubiquitinated protein deubiquitination (GO:0035520)2.83921423
56regulation of synaptic vesicle exocytosis (GO:2000300)2.80435652
57negative regulation of cytosolic calcium ion concentration (GO:0051481)2.79492740
58regulation of mast cell degranulation (GO:0043304)2.79106009
59nerve growth factor signaling pathway (GO:0038180)2.79039640
60regulation of clathrin-mediated endocytosis (GO:2000369)2.77886560
61vesicle transport along microtubule (GO:0047496)2.75230667
62regulation of B cell receptor signaling pathway (GO:0050855)2.74215880
63regulation of cell communication by electrical coupling (GO:0010649)2.74014535
64proline transport (GO:0015824)2.73877448
65peptidyl-lysine dimethylation (GO:0018027)2.73256865
66cellular sodium ion homeostasis (GO:0006883)2.72899560
67positive regulation of histone deacetylation (GO:0031065)2.71273236
68negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.68989023
69negative regulation of neurotransmitter secretion (GO:0046929)2.67421159
70negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.67040932
71dendrite morphogenesis (GO:0048813)2.65805721
72phospholipid translocation (GO:0045332)2.64571612
73lipid translocation (GO:0034204)2.64571612
74exploration behavior (GO:0035640)2.64469333
75regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.63975458
76dicarboxylic acid biosynthetic process (GO:0043650)2.63050428
77positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.62408780
78negative regulation of cell size (GO:0045792)2.62362822
79insulin-like growth factor receptor signaling pathway (GO:0048009)2.62229104
80Golgi transport vesicle coating (GO:0048200)2.62211225
81COPI coating of Golgi vesicle (GO:0048205)2.62211225
82pericardium development (GO:0060039)2.59545100
83sarcoplasmic reticulum calcium ion transport (GO:0070296)2.58905663
84regulation of skeletal muscle contraction (GO:0014819)2.57950803
85muscle filament sliding (GO:0030049)2.57172417
86actin-myosin filament sliding (GO:0033275)2.57172417
87regulation of ARF GTPase activity (GO:0032312)2.55500276
88neuromuscular process controlling balance (GO:0050885)2.52701590
89glycogen catabolic process (GO:0005980)2.52643200
90regulation of fatty acid beta-oxidation (GO:0031998)2.52174280
91neurotransmitter secretion (GO:0007269)2.52070075
92regulation of acyl-CoA biosynthetic process (GO:0050812)2.51354158
93synaptic vesicle exocytosis (GO:0016079)2.50389805
94membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.49800411
95alanine transport (GO:0032328)2.49327958
96stress fiber assembly (GO:0043149)2.49263357
97cytoplasmic mRNA processing body assembly (GO:0033962)2.48840847
98regulation of synaptic vesicle transport (GO:1902803)2.48163566
99clathrin coat assembly (GO:0048268)2.47862915
100glucan catabolic process (GO:0009251)2.47180353
101macroautophagy (GO:0016236)2.46833181
102regulation of establishment of cell polarity (GO:2000114)2.46415493
103hepatocyte apoptotic process (GO:0097284)2.46034579
104regulation of isotype switching to IgG isotypes (GO:0048302)2.45807574
105negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.45698446
106cellular biogenic amine biosynthetic process (GO:0042401)2.44159695
107regulation of glutamate receptor signaling pathway (GO:1900449)2.42754691
108regulation of skeletal muscle cell differentiation (GO:2001014)2.42334339
109retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.41500760
110cell communication involved in cardiac conduction (GO:0086065)2.40629177
111detection of calcium ion (GO:0005513)2.40446127
112cellular polysaccharide catabolic process (GO:0044247)2.38706758
113negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.36681989
114positive regulation of fatty acid beta-oxidation (GO:0032000)2.36114400
115negative regulation of cell killing (GO:0031342)2.36016951
116negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.36016951
117positive regulation of gamma-delta T cell activation (GO:0046645)2.35312675
118vocalization behavior (GO:0071625)2.34956218
119cerebellar Purkinje cell differentiation (GO:0021702)2.34824353
120B cell receptor signaling pathway (GO:0050853)2.34737940
121regulation of neuronal synaptic plasticity (GO:0048168)2.34587499
122mRNA transcription (GO:0009299)2.34339725
123T cell apoptotic process (GO:0070231)2.33537327
124carnitine shuttle (GO:0006853)2.33096995
125positive regulation of glycogen biosynthetic process (GO:0045725)2.33008776
126actin-mediated cell contraction (GO:0070252)2.32996473
127negative regulation of adaptive immune response (GO:0002820)2.32886334
128CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.32225867
129skeletal muscle adaptation (GO:0043501)2.31750622
130regulation of release of sequestered calcium ion into cytosol (GO:0051279)2.30330605
131negative regulation of potassium ion transmembrane transport (GO:1901380)2.30116065
132regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.30105254
133neurotransmitter uptake (GO:0001504)2.29992498
134protein targeting to vacuole (GO:0006623)2.29086944
135protein targeting to lysosome (GO:0006622)2.29086944
136establishment of protein localization to vacuole (GO:0072666)2.29086944
137dendritic spine morphogenesis (GO:0060997)2.27772138
138regulation of long-term neuronal synaptic plasticity (GO:0048169)2.26852654
139regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.26472971
140regulation of Rap GTPase activity (GO:0032317)2.26264930
141membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.26200265
142tyrosine phosphorylation of STAT protein (GO:0007260)2.25756534
143negative regulation of heart contraction (GO:0045822)2.25752128
144negative regulation of sodium ion transport (GO:0010766)2.25111509
145cerebellar Purkinje cell layer development (GO:0021680)2.23523330
146regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.23006512
147gamma-aminobutyric acid transport (GO:0015812)2.21865363
148alpha-linolenic acid metabolic process (GO:0036109)2.21608047
149interkinetic nuclear migration (GO:0022027)2.20915671
150regulation of calcium ion transmembrane transport (GO:1903169)2.20558398
151regulation of calcium ion transmembrane transporter activity (GO:1901019)2.20558398
152fatty acid transmembrane transport (GO:1902001)2.20380031
153positive regulation of Rap GTPase activity (GO:0032854)2.20268935
154growth hormone receptor signaling pathway (GO:0060396)2.19497273
155peptidyl-threonine phosphorylation (GO:0018107)2.18877102
156peptidyl-threonine modification (GO:0018210)2.18378808
157regulation of coenzyme metabolic process (GO:0051196)2.18364241
158regulation of cofactor metabolic process (GO:0051193)2.18364241
159membrane repolarization (GO:0086009)2.17639857
160prepulse inhibition (GO:0060134)2.17199996
161phosphatidylinositol dephosphorylation (GO:0046856)2.16781567
162negative regulation of vascular permeability (GO:0043116)2.16263395
163membrane depolarization during action potential (GO:0086010)2.14911761
164endoplasmic reticulum organization (GO:0007029)2.14700333
165phospholipid dephosphorylation (GO:0046839)2.14670502
166activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.14310451
167regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.14238736
168NLS-bearing protein import into nucleus (GO:0006607)2.13838405
169protein targeting to plasma membrane (GO:0072661)2.13169337
170organelle transport along microtubule (GO:0072384)2.12982105
171regulation of dendritic spine morphogenesis (GO:0061001)2.12320026
172G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.11363750
173glycine transport (GO:0015816)2.11321428
174positive regulation of fibroblast migration (GO:0010763)2.11024266
175regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.08317408
176positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.07806878
177vesicle coating (GO:0006901)2.07537063
178nucleus localization (GO:0051647)2.07286690
179potassium ion homeostasis (GO:0055075)2.06557464
180negative regulation of fatty acid transport (GO:2000192)2.05420065
181regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.03746341

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.63200115
2EZH2_22144423_ChIP-Seq_EOC_Human2.80052749
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.73709217
4POU3F2_20337985_ChIP-ChIP_501MEL_Human2.53137629
5CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.51559622
6GBX2_23144817_ChIP-Seq_PC3_Human2.22700762
7DROSHA_22980978_ChIP-Seq_HELA_Human2.21175458
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.18020612
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.18001618
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.15703916
11EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.95306820
12RARB_27405468_Chip-Seq_BRAIN_Mouse1.94917622
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.89674845
14RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.89438589
15MYB_21317192_ChIP-Seq_ERMYB_Mouse1.82594053
16IGF1R_20145208_ChIP-Seq_DFB_Human1.78855338
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.72179888
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70755141
19TAF15_26573619_Chip-Seq_HEK293_Human1.68600507
20KDM2B_26808549_Chip-Seq_SUP-B15_Human1.67764328
21* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.64697435
22KDM2B_26808549_Chip-Seq_DND41_Human1.62737804
23TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.61902908
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.60732292
25Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.60224830
26KDM2B_26808549_Chip-Seq_K562_Human1.59982036
27SMAD4_21799915_ChIP-Seq_A2780_Human1.59840369
28WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.59197209
29SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.57094311
30OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.56755099
31STAT3_23295773_ChIP-Seq_U87_Human1.56036566
32PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.55113882
33BP1_19119308_ChIP-ChIP_Hs578T_Human1.54655769
34ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.53474549
35TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.51811383
36DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.51353870
37TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.50896997
38SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.50682752
39ER_23166858_ChIP-Seq_MCF-7_Human1.50010100
40MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.49903328
41ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.49738932
42ZNF217_24962896_ChIP-Seq_MCF-7_Human1.48846211
43EGR1_19374776_ChIP-ChIP_THP-1_Human1.47991117
44NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.47867725
45MTF2_20144788_ChIP-Seq_MESCs_Mouse1.47641932
46FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.47121669
47FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.47025126
48WT1_19549856_ChIP-ChIP_CCG9911_Human1.44765815
49* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.44534394
50ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.44522017
51NANOG_18555785_Chip-Seq_ESCs_Mouse1.43980217
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.43464715
53FOXA2_19822575_ChIP-Seq_HepG2_Human1.41875153
54GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.39672576
55* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.39385307
56EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.39364825
57SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.39163130
58E2F1_18555785_Chip-Seq_ESCs_Mouse1.39149428
59BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.38791428
60SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.37518569
61WT1_25993318_ChIP-Seq_PODOCYTE_Human1.35353016
62EZH2_27294783_Chip-Seq_NPCs_Mouse1.35317041
63TCF7_22412390_ChIP-Seq_EML_Mouse1.34537996
64CLOCK_20551151_ChIP-Seq_293T_Human1.34313814
65KDM2B_26808549_Chip-Seq_JURKAT_Human1.34098224
66LXR_22158963_ChIP-Seq_LIVER_Mouse1.33667562
67CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.32387131
68MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32073191
69EZH2_18974828_ChIP-Seq_MESCs_Mouse1.31820268
70RNF2_18974828_ChIP-Seq_MESCs_Mouse1.31820268
71CDX2_19796622_ChIP-Seq_MESCs_Mouse1.31392997
72SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.31214054
73GATA1_22025678_ChIP-Seq_K562_Human1.30847257
74VDR_24787735_ChIP-Seq_THP-1_Human1.30724438
75KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.30723516
76SCL_19346495_ChIP-Seq_HPC-7_Human1.30075558
77ESR1_20079471_ChIP-ChIP_T-47D_Human1.29959971
78* TCF4_23295773_ChIP-Seq_U87_Human1.29479544
79SUZ12_27294783_Chip-Seq_NPCs_Mouse1.29427311
80BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.28461290
81AR_21572438_ChIP-Seq_LNCaP_Human1.28212726
82NRF2_20460467_ChIP-Seq_MEFs_Mouse1.28031508
83NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.28031508
84FUS_26573619_Chip-Seq_HEK293_Human1.27278956
85CTNNB1_20460455_ChIP-Seq_HCT116_Human1.26568886
86PCGF2_27294783_Chip-Seq_ESCs_Mouse1.25973475
87FOXO3_23340844_ChIP-Seq_DLD1_Human1.25626823
88SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.25347213
89SUZ12_18555785_Chip-Seq_ESCs_Mouse1.25019313
90P53_22387025_ChIP-Seq_ESCs_Mouse1.24661970
91ESR2_21235772_ChIP-Seq_MCF-7_Human1.22604911
92P300_27058665_Chip-Seq_ZR-75-30cells_Human1.22518232
93EP300_21415370_ChIP-Seq_HL-1_Mouse1.22479206
94MYB_26560356_Chip-Seq_TH2_Human1.22151426
95RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.22015096
96FLI1_21867929_ChIP-Seq_TH2_Mouse1.20627239
97ZFP281_18757296_ChIP-ChIP_E14_Mouse1.20227885
98STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.20104337
99EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.19881176
100FOXM1_26456572_ChIP-Seq_MCF-7_Human1.19642611
101THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.19213189
102ZFP281_27345836_Chip-Seq_ESCs_Mouse1.18960345
103P300_19829295_ChIP-Seq_ESCs_Human1.17392088
104SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.16816391
105RXR_22158963_ChIP-Seq_LIVER_Mouse1.16775748
106TP53_16413492_ChIP-PET_HCT116_Human1.16227706
107NR3C1_23031785_ChIP-Seq_PC12_Mouse1.15998668
108PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.15845661
109ZNF263_19887448_ChIP-Seq_K562_Human1.15536592
110SOX2_18555785_Chip-Seq_ESCs_Mouse1.15418038
111TBX20_22080862_ChIP-Seq_HEART_Mouse1.14995030
112TBX20_22328084_ChIP-Seq_HEART_Mouse1.14995030
113STAT3_18555785_Chip-Seq_ESCs_Mouse1.14971449
114CRX_20693478_ChIP-Seq_RETINA_Mouse1.14956063
115GATA1_19941826_ChIP-Seq_K562_Human1.14722060
116CMYC_18555785_Chip-Seq_ESCs_Mouse1.14592237
117IRF8_27001747_Chip-Seq_BMDM_Mouse1.14575893
118OCT4_18555785_Chip-Seq_ESCs_Mouse1.13405565
119SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.12212980
120AR_19668381_ChIP-Seq_PC3_Human1.12150868
121PCGF2_27294783_Chip-Seq_NPCs_Mouse1.11738971
122EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.11542639
123NMYC_18555785_Chip-Seq_ESCs_Mouse1.11476103
124OCT4_21477851_ChIP-Seq_ESCs_Mouse1.10767455
125LXR_22292898_ChIP-Seq_THP-1_Human1.10755196
126PRDM14_20953172_ChIP-Seq_ESCs_Human1.10634018
127VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.10323191
128REST_21632747_ChIP-Seq_MESCs_Mouse1.10180764
129SOX2_21211035_ChIP-Seq_LN229_Gbm1.09970552
130NFE2_27457419_Chip-Seq_LIVER_Mouse1.09932354
131SMAD_19615063_ChIP-ChIP_OVARY_Human1.09073393
132SPI1_23127762_ChIP-Seq_K562_Human1.08943449
133DNAJC2_21179169_ChIP-ChIP_NT2_Human1.08827336
134SMAD1_18555785_Chip-Seq_ESCs_Mouse1.08743136
135CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.08665647
136PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08106398
137P300_18555785_Chip-Seq_ESCs_Mouse1.08069675
138* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.07736434
139RXR_22108803_ChIP-Seq_LS180_Human1.07594760
140CTCF_18555785_Chip-Seq_ESCs_Mouse1.07199731
141CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.06244054
142SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.06074880
143EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.05451623
144ZNF274_21170338_ChIP-Seq_K562_Hela1.04573400
145IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04563891
146CBP_20019798_ChIP-Seq_JUKART_Human1.04563891
147TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04045642
148AHR_22903824_ChIP-Seq_MCF-7_Human1.03802585
149JARID2_20064375_ChIP-Seq_MESCs_Mouse1.03404551
150KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02989193
151ARNT_22903824_ChIP-Seq_MCF-7_Human1.02693631
152PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.01586251
153PPARA_22158963_ChIP-Seq_LIVER_Mouse1.00320980
154JARID2_20075857_ChIP-Seq_MESCs_Mouse0.99868663
155ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99014073
156TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.98865246
157BRD4_25478319_ChIP-Seq_HGPS_Human0.98742363
158SUZ12_27294783_Chip-Seq_ESCs_Mouse0.98689337
159ZFX_18555785_Chip-Seq_ESCs_Mouse0.98620403
160RNF2_27304074_Chip-Seq_ESCs_Mouse0.98201876
161AR_25329375_ChIP-Seq_VCAP_Human0.97860176
162SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.95962567
163EZH2_27294783_Chip-Seq_ESCs_Mouse0.95258589
164REST_18959480_ChIP-ChIP_MESCs_Mouse0.94998684
165TRIM28_21343339_ChIP-Seq_HEK293_Human0.94869938
166MYC_22102868_ChIP-Seq_BL_Human0.94032036
167SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.93233735
168RUNX_20019798_ChIP-Seq_JUKART_Human0.92889918
169ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.92441174
170GATA2_21666600_ChIP-Seq_HMVEC_Human0.92070789
171FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.92020549
172NFIB_24661679_ChIP-Seq_LUNG_Mouse0.91068871
173CREB1_26743006_Chip-Seq_LNCaP_Human0.90364339
174GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90048126
175AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.90028860
176AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90018699
177PPAR_26484153_Chip-Seq_NCI-H1993_Human0.89911712

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.89816527
2MP0008057_abnormal_DNA_replication3.61957858
3MP0002735_abnormal_chemical_nociception3.34560028
4MP0003300_gastrointestinal_ulcer3.17506179
5MP0009780_abnormal_chondrocyte_physiolo3.16721137
6MP0000569_abnormal_digit_pigmentation3.12931118
7MP0010234_abnormal_vibrissa_follicle2.85564687
8MP0003705_abnormal_hypodermis_morpholog2.81778589
9MP0004130_abnormal_muscle_cell2.67328777
10MP0005171_absent_coat_pigmentation2.66416327
11MP0002909_abnormal_adrenal_gland2.60628540
12MP0002009_preneoplasia2.50995428
13MP0008961_abnormal_basal_metabolism2.37899403
14MP0002638_abnormal_pupillary_reflex2.30707776
15MP0003635_abnormal_synaptic_transmissio2.27899311
16MP0003950_abnormal_plasma_membrane2.27500323
17MP0004270_analgesia2.26660434
18MP0005075_abnormal_melanosome_morpholog2.15317009
19MP0000372_irregular_coat_pigmentation2.09733147
20MP0000013_abnormal_adipose_tissue2.08099535
21MP0000015_abnormal_ear_pigmentation2.01185855
22MP0003252_abnormal_bile_duct1.96238940
23MP0000751_myopathy1.94058918
24MP0003787_abnormal_imprinting1.80735593
25MP0003045_fibrosis1.79100437
26MP0004858_abnormal_nervous_system1.73045944
27MP0005174_abnormal_tail_pigmentation1.71742340
28MP0008877_abnormal_DNA_methylation1.70493423
29MP0003303_peritoneal_inflammation1.70270257
30MP0003763_abnormal_thymus_physiology1.69837083
31MP0002063_abnormal_learning/memory/cond1.62766776
32MP0001835_abnormal_antigen_presentation1.62651073
33MP0009115_abnormal_fat_cell1.58713332
34MP0003329_amyloid_beta_deposits1.57653330
35MP0003172_abnormal_lysosome_physiology1.54505010
36MP0002877_abnormal_melanocyte_morpholog1.53543054
37MP0000747_muscle_weakness1.53306632
38MP0004233_abnormal_muscle_weight1.52254524
39MP0008569_lethality_at_weaning1.46241494
40MP0003221_abnormal_cardiomyocyte_apopto1.45884458
41MP0000003_abnormal_adipose_tissue1.43297709
42MP0004087_abnormal_muscle_fiber1.43004039
43MP0004185_abnormal_adipocyte_glucose1.41595200
44MP0003283_abnormal_digestive_organ1.41408270
45MP0005076_abnormal_cell_differentiation1.40853932
46MP0003656_abnormal_erythrocyte_physiolo1.37136136
47MP0002837_dystrophic_cardiac_calcinosis1.36120494
48MP0003633_abnormal_nervous_system1.35502172
49MP0004084_abnormal_cardiac_muscle1.35226124
50MP0003075_altered_response_to1.35038980
51MP0004036_abnormal_muscle_relaxation1.32074210
52MP0009745_abnormal_behavioral_response1.31712743
53MP0004811_abnormal_neuron_physiology1.31686475
54MP0005187_abnormal_penis_morphology1.31530044
55MP0000604_amyloidosis1.30232045
56MP0002332_abnormal_exercise_endurance1.30147430
57MP0002064_seizures1.29628693
58MP0003690_abnormal_glial_cell1.28148807
59MP0000371_diluted_coat_color1.26798979
60MP0009046_muscle_twitch1.26003999
61MP0001299_abnormal_eye_distance/1.25503123
62MP0004145_abnormal_muscle_electrophysio1.25481003
63MP0005167_abnormal_blood-brain_barrier1.25424949
64MP0005666_abnormal_adipose_tissue1.24299158
65MP0003828_pulmonary_edema1.23336887
66MP0003183_abnormal_peptide_metabolism1.23216464
67MP0010352_gastrointestinal_tract_polyps1.21783885
68MP0005375_adipose_tissue_phenotype1.21372274
69MP0002396_abnormal_hematopoietic_system1.20175790
70MP0001800_abnormal_humoral_immune1.16002658
71MP0004510_myositis1.12789466
72MP0003091_abnormal_cell_migration1.12415599
73MP0002928_abnormal_bile_duct1.12286069
74MP0005464_abnormal_platelet_physiology1.12202021
75MP0002269_muscular_atrophy1.11960086
76MP0001984_abnormal_olfaction1.11195103
77MP0010329_abnormal_lipoprotein_level1.10520561
78MP0005310_abnormal_salivary_gland1.09248945
79MP0002822_catalepsy1.08864551
80MP0005623_abnormal_meninges_morphology1.07657103
81MP0000733_abnormal_muscle_development1.05758513
82MP0002139_abnormal_hepatobiliary_system1.04177401
83MP0002896_abnormal_bone_mineralization1.03385821
84MP0002138_abnormal_hepatobiliary_system1.02518484
85MP0005360_urolithiasis1.01164293
86MP0004215_abnormal_myocardial_fiber1.00151202
87MP0004885_abnormal_endolymph0.99287674
88MP0002095_abnormal_skin_pigmentation0.98918192
89MP0001958_emphysema0.97795150
90MP0002398_abnormal_bone_marrow0.97094982
91MP0001873_stomach_inflammation0.96774000
92MP0000465_gastrointestinal_hemorrhage0.96141509
93MP0002006_tumorigenesis0.94165589
94MP0004381_abnormal_hair_follicle0.93325222
95MP0002572_abnormal_emotion/affect_behav0.93063947
96MP0003566_abnormal_cell_adhesion0.92790937
97MP0010630_abnormal_cardiac_muscle0.92328989
98MP0002734_abnormal_mechanical_nocicepti0.92060750
99MP0005365_abnormal_bile_salt0.91970237
100MP0005620_abnormal_muscle_contractility0.91435883
101MP0010386_abnormal_urinary_bladder0.91332807
102MP0000759_abnormal_skeletal_muscle0.90305631
103MP0000703_abnormal_thymus_morphology0.90202708
104MP0008438_abnormal_cutaneous_collagen0.90150902
105MP0003631_nervous_system_phenotype0.89227102
106MP0002067_abnormal_sensory_capabilities0.89195590
107MP0001968_abnormal_touch/_nociception0.88416794
108MP0008874_decreased_physiological_sensi0.88146450
109MP0002089_abnormal_postnatal_growth/wei0.88046441
110MP0002078_abnormal_glucose_homeostasis0.87729516
111MP0002127_abnormal_cardiovascular_syste0.87153713
112MP0002272_abnormal_nervous_system0.86579006
113MP0002971_abnormal_brown_adipose0.86105091
114MP0000749_muscle_degeneration0.85105366
115MP0001348_abnormal_lacrimal_gland0.84502249
116MP0006276_abnormal_autonomic_nervous0.84034719
117MP0002166_altered_tumor_susceptibility0.83921584
118MP0005334_abnormal_fat_pad0.83862766
119MP0001486_abnormal_startle_reflex0.82746541
120MP0001849_ear_inflammation0.82560463
121MP0005058_abnormal_lysosome_morphology0.79828338
122MP0001765_abnormal_ion_homeostasis0.79422118
123MP0005369_muscle_phenotype0.79377510
124MP0001790_abnormal_immune_system0.79264019
125MP0005387_immune_system_phenotype0.79264019
126MP0006054_spinal_hemorrhage0.79020467
127MP0006138_congestive_heart_failure0.79000461
128MP0005535_abnormal_body_temperature0.78610051
129MP0004147_increased_porphyrin_level0.77341336
130MP0002405_respiratory_system_inflammati0.77096836
131MP0002118_abnormal_lipid_homeostasis0.77028039
132MP0002168_other_aberrant_phenotype0.76241597
133MP0002420_abnormal_adaptive_immunity0.75775355
134MP0004808_abnormal_hematopoietic_stem0.75518687
135MP0004085_abnormal_heartbeat0.74745100
136MP0002148_abnormal_hypersensitivity_rea0.74338438
137MP0004484_altered_response_of0.74297767
138MP0003646_muscle_fatigue0.73554097
139MP0000920_abnormal_myelination0.73549579
140MP0000716_abnormal_immune_system0.73376077
141MP0001819_abnormal_immune_cell0.73138149
142MP0002972_abnormal_cardiac_muscle0.72649556
143MP0002733_abnormal_thermal_nociception0.72354336
144MP0005166_decreased_susceptibility_to0.71987662
145MP0002723_abnormal_immune_serum0.71766719
146MP0001501_abnormal_sleep_pattern0.71636807
147MP0001970_abnormal_pain_threshold0.71054891
148MP0005083_abnormal_biliary_tract0.71036174
149MP0004043_abnormal_pH_regulation0.70947995
150MP0002106_abnormal_muscle_physiology0.70862220
151MP0006082_CNS_inflammation0.69315202
152MP0002090_abnormal_vision0.68917736
153MP0000955_abnormal_spinal_cord0.68221378
154MP0002722_abnormal_immune_system0.67737782
155MP0009697_abnormal_copulation0.67338109

Predicted human phenotypes

RankGene SetZ-score
1Nemaline bodies (HP:0003798)4.91032984
2Muscle fiber inclusion bodies (HP:0100299)4.72638613
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.58227120
4T lymphocytopenia (HP:0005403)3.82062195
5Abnormality of T cell number (HP:0011839)3.42567652
6Papilledema (HP:0001085)3.28326800
7Papillary thyroid carcinoma (HP:0002895)3.21925790
8Abnormal delayed hypersensitivity skin test (HP:0002963)3.20226470
9Subaortic stenosis (HP:0001682)3.14299804
10Abnormality of the left ventricular outflow tract (HP:0011103)3.14299804
11Chronic mucocutaneous candidiasis (HP:0002728)3.07049534
12Recurrent cutaneous fungal infections (HP:0011370)3.07049534
13Febrile seizures (HP:0002373)3.00942609
14Action tremor (HP:0002345)3.00810975
15Macroorchidism (HP:0000053)2.98257579
16Hyperkalemia (HP:0002153)2.87100520
17Autoimmune hemolytic anemia (HP:0001890)2.84785184
18Cerebral aneurysm (HP:0004944)2.80984203
19Panhypogammaglobulinemia (HP:0003139)2.80272926
20Dysmetric saccades (HP:0000641)2.78904275
21Distal arthrogryposis (HP:0005684)2.76693157
22Atonic seizures (HP:0010819)2.74027177
23Failure to thrive in infancy (HP:0001531)2.73812745
24Thyroiditis (HP:0100646)2.73398260
25Spontaneous hematomas (HP:0007420)2.71169518
26Recurrent viral infections (HP:0004429)2.66616862
27Visual hallucinations (HP:0002367)2.65834308
28Difficulty running (HP:0009046)2.61604420
29Increased circulating renin level (HP:0000848)2.59012596
30Blue irides (HP:0000635)2.58081538
31EMG: myopathic abnormalities (HP:0003458)2.57977364
32Exercise-induced myalgia (HP:0003738)2.54370724
33Bundle branch block (HP:0011710)2.47048908
34Abnormality of T cells (HP:0002843)2.43150357
35Recurrent fungal infections (HP:0002841)2.42166359
36Muscle hypertrophy of the lower extremities (HP:0008968)2.39575761
37Hyperacusis (HP:0010780)2.39107450
38Abnormality of the lower motor neuron (HP:0002366)2.37840884
39Severe combined immunodeficiency (HP:0004430)2.37679093
40Myokymia (HP:0002411)2.36446010
41Hyporeflexia of lower limbs (HP:0002600)2.34521018
42Albinism (HP:0001022)2.30663056
43Focal seizures (HP:0007359)2.28532303
44Impaired vibration sensation in the lower limbs (HP:0002166)2.28354239
45Calf muscle hypertrophy (HP:0008981)2.28099316
46Male infertility (HP:0003251)2.24758591
47Postural instability (HP:0002172)2.24304068
48Exercise-induced muscle cramps (HP:0003710)2.23983535
49Hemiplegia (HP:0002301)2.23884434
50Subacute progressive viral hepatitis (HP:0006572)2.23803565
51Resting tremor (HP:0002322)2.23444073
52Urinary bladder sphincter dysfunction (HP:0002839)2.22677172
53Gaze-evoked nystagmus (HP:0000640)2.20971395
54Neoplasm of the tracheobronchial system (HP:0100552)2.20752506
55Supranuclear gaze palsy (HP:0000605)2.20445232
56Broad metatarsal (HP:0001783)2.19359408
57Fair hair (HP:0002286)2.18896034
58Thyroid carcinoma (HP:0002890)2.18257801
59Aortic aneurysm (HP:0004942)2.18185513
60Urinary urgency (HP:0000012)2.17891612
61Ankle clonus (HP:0011448)2.17045963
62Lymphangioma (HP:0100764)2.16035729
63Generalized hypopigmentation of hair (HP:0011358)2.15621303
64Impaired social interactions (HP:0000735)2.15506183
65Abnormal social behavior (HP:0012433)2.15506183
66Abnormality of T cell physiology (HP:0011840)2.14823622
67Insomnia (HP:0100785)2.14567426
68Depression (HP:0000716)2.14549314
69Termporal pattern (HP:0011008)2.13783928
70Insidious onset (HP:0003587)2.13783928
71Enlarged penis (HP:0000040)2.12148632
72Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.12033372
73Long toe (HP:0010511)2.12002872
74Cutaneous melanoma (HP:0012056)2.10286819
75Steppage gait (HP:0003376)2.09880391
76Ankyloglossia (HP:0010296)2.09270692
77EMG: neuropathic changes (HP:0003445)2.07709882
78Distal upper limb amyotrophy (HP:0007149)2.07454208
79Upper limb amyotrophy (HP:0009129)2.07454208
80Alveolar cell carcinoma (HP:0006519)2.06760070
81Abnormality of skeletal muscle fiber size (HP:0012084)2.06632854
82Long clavicles (HP:0000890)2.05509228
83Striae distensae (HP:0001065)2.05020133
84Elfin facies (HP:0004428)2.04627391
85Frequent falls (HP:0002359)2.04560731
86Intention tremor (HP:0002080)2.01720451
87Viral hepatitis (HP:0006562)2.01528570
88Mitral valve prolapse (HP:0001634)2.00938461
89Autoimmune thrombocytopenia (HP:0001973)2.00620405
90Absence seizures (HP:0002121)2.00049830
91Aneurysm (HP:0002617)1.99054686
92IgG deficiency (HP:0004315)1.98927646
93Acute hepatic failure (HP:0006554)1.98099423
94Shallow orbits (HP:0000586)1.96629039
95Pointed chin (HP:0000307)1.96349445
96Focal motor seizures (HP:0011153)1.96207131
97Impaired proprioception (HP:0010831)1.95754460
98Episodic fever (HP:0001954)1.93965656
99Hypokalemic alkalosis (HP:0001949)1.93260629
100Muscle fiber splitting (HP:0003555)1.93058774
101Ventricular fibrillation (HP:0001663)1.93054331
102Rimmed vacuoles (HP:0003805)1.92952406
103Poor eye contact (HP:0000817)1.92455598
104Diplopia (HP:0000651)1.91998702
105Abnormality of binocular vision (HP:0011514)1.91998702
106Colitis (HP:0002583)1.91530673
107Truncal ataxia (HP:0002078)1.90416138
108Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.88929237
109Atrioventricular block (HP:0001678)1.88618193
110Areflexia of lower limbs (HP:0002522)1.88009224
111Genetic anticipation (HP:0003743)1.86965952
112Ketoacidosis (HP:0001993)1.85711137
113Hematochezia (HP:0002573)1.84293610
114Dialeptic seizures (HP:0011146)1.83249089
115Increased CSF protein (HP:0002922)1.82820686
116Impaired smooth pursuit (HP:0007772)1.82685770
117Abnormality of oral frenula (HP:0000190)1.82173120
118Premature graying of hair (HP:0002216)1.82134020
119Chest pain (HP:0100749)1.81516605
120Rhabdomyolysis (HP:0003201)1.80926991
121Dilatation of the ascending aorta (HP:0005111)1.80857574
122Bowel diverticulosis (HP:0005222)1.80420673
123B lymphocytopenia (HP:0010976)1.80317674
124Hand muscle atrophy (HP:0009130)1.79788871
125Myoglobinuria (HP:0002913)1.79281121
126Abnormality of B cell number (HP:0010975)1.78810125
127Hypoplasia of the thymus (HP:0000778)1.78749081
128Facial diplegia (HP:0001349)1.78562343
129Type 1 muscle fiber predominance (HP:0003803)1.78104073
130Recurrent skin infections (HP:0001581)1.78060996
131Heart block (HP:0012722)1.77129931
132Vertebral arch anomaly (HP:0008438)1.76954788
133Lower limb amyotrophy (HP:0007210)1.76760167
134Abnormality of the calf musculature (HP:0001430)1.76682784
135Agammaglobulinemia (HP:0004432)1.76127360
136Pheochromocytoma (HP:0002666)1.74760049
137Bilateral sensorineural hearing impairment (HP:0008619)1.74642091
138Short chin (HP:0000331)1.74598040
139Increased variability in muscle fiber diameter (HP:0003557)1.74267127
140Deep venous thrombosis (HP:0002625)1.73477848
141Asymmetric septal hypertrophy (HP:0001670)1.72872646
142Neoplasm of the heart (HP:0100544)1.72262564
143Achilles tendon contracture (HP:0001771)1.70983509
144Global brain atrophy (HP:0002283)1.70851180
145Renovascular hypertension (HP:0100817)1.69415960
146Abnormality of the Achilles tendon (HP:0005109)1.69300079
147Abnormality of ocular smooth pursuit (HP:0000617)1.67996084
148Hamartoma of the eye (HP:0010568)1.67336817
149Narrow palate (HP:0000189)1.66151967
150Rapidly progressive (HP:0003678)1.65050144
151Megalencephaly (HP:0001355)1.63710738
152Dysdiadochokinesis (HP:0002075)1.63286975
153Increased connective tissue (HP:0009025)1.63198089
154Mitral stenosis (HP:0001718)1.62928867
155Difficulty climbing stairs (HP:0003551)1.62682980
156Buphthalmos (HP:0000557)1.61317627
157Progressive cerebellar ataxia (HP:0002073)1.59982954
158Sudden death (HP:0001699)1.59757999
159Cerebral inclusion bodies (HP:0100314)1.58787759
160Turricephaly (HP:0000262)1.57502730
161Increased density of long bones (HP:0006392)1.56816298
162Mildly elevated creatine phosphokinase (HP:0008180)1.56009548
163Heterotopia (HP:0002282)1.55940812
164Obsessive-compulsive behavior (HP:0000722)1.55137976
165Impaired vibratory sensation (HP:0002495)1.55021203
166Hypercortisolism (HP:0001578)1.54840053
167Spastic gait (HP:0002064)1.54068091
168Hammertoe (HP:0001765)1.53785554
169Lower limb muscle weakness (HP:0007340)1.53477709
170Arterial tortuosity (HP:0005116)1.53189738
171Dysmetria (HP:0001310)1.51363701
172Protrusio acetabuli (HP:0003179)1.51360008
173Exostoses (HP:0100777)1.51359978
174Scapular winging (HP:0003691)1.51058402

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM284.47917560
2TRIB33.81777080
3OBSCN3.58238157
4PKN22.62226296
5AKT32.58141502
6RIPK12.50636087
7PRKD32.43500255
8MAP3K92.42450491
9PIK3CG2.22372211
10BMPR22.19984708
11KSR22.16029016
12NTRK32.08566020
13PRPF4B2.05699618
14CAMKK12.00268164
15TTN1.95476702
16SCYL21.91409511
17CAMK1G1.83449752
18PAK61.76324816
19EEF2K1.75435273
20DMPK1.75231626
21DAPK21.69069662
22LMTK21.67625325
23PDGFRA1.64463811
24MAP3K21.61240760
25RET1.58012342
26TRPM71.57242381
27CAMK1D1.55731481
28SIK11.52981228
29PTK61.52116798
30EPHA41.49055156
31PNCK1.48036986
32FRK1.46261178
33NEK91.44113595
34NTRK11.43832235
35PRKCH1.36271056
36MAP3K41.34112578
37MAP3K71.33378855
38SGK31.28093445
39TAOK11.26565682
40MINK11.26290814
41TEC1.25676021
42FGFR21.23644100
43STK381.23347972
44MAP2K41.22309674
45TXK1.20833538
46KSR11.13943152
47MARK11.13927958
48MAP3K101.12992557
49PHKG21.12801819
50PHKG11.12801819
51MAPK131.12200001
52PDK31.11245672
53PDK41.11245672
54FGFR31.08575922
55ERN11.08268208
56SIK21.08129523
57CAMKK21.07366337
58JAK11.05877978
59ALK1.05023275
60MAPK121.02964835
61PDK11.01403743
62TYK21.01285188
63TYRO31.01196283
64BRSK21.00273131
65MARK31.00196269
66PIK3CA0.99833671
67MAP3K120.99785873
68NTRK20.97795248
69TNIK0.97369070
70SIK30.94814879
71LATS10.90659901
72WNK10.90468289
73PLK20.89821741
74PAK30.89108207
75SYK0.88544305
76PDK20.87870026
77PDPK10.87350647
78CSF1R0.86551083
79CDK50.86215501
80MAP3K10.86053353
81LRRK20.83845746
82PDGFRB0.83253939
83STK240.81019882
84NEK10.79933245
85BLK0.79627844
86DDR20.79526989
87FGFR40.78249290
88ICK0.77975574
89IKBKE0.77907274
90CSK0.77388794
91SGK20.76928812
92BMX0.75218272
93NEK60.74928327
94JAK20.73937906
95STK110.73714975
96MAP3K60.73194825
97EIF2AK30.72331993
98RIPK40.71999688
99STK38L0.70125794
100FGR0.68000797
101CCNB10.67671048
102MAP3K130.67306837
103PTK20.66426964
104YES10.66297961
105MUSK0.66177918
106BTK0.64766453
107MAPK100.64128167
108MTOR0.63775865
109MAP4K20.62921052
110NLK0.62707295
111MAP3K140.61709268
112CDK60.61648787
113ITK0.61209286
114PRKAA10.60303541
115CDC42BPA0.59793689
116SGK10.58753307
117PRKD10.58103644
118MARK20.57672580
119HIPK20.57479132
120PTK2B0.56777524
121SGK4940.56371540
122SGK2230.56371540
123FER0.56019783
124CAMK2B0.55777617
125MAPK110.54781748
126FGFR10.52528039
127INSRR0.52266805
128RPS6KB10.51061878
129RPS6KA30.48547272
130RPS6KA20.48423688
131BRD40.48063785
132PRKAA20.47866959
133EPHB10.47565187
134JAK30.47551048
135CAMK10.47448466
136FES0.47423497
137MELK0.47154230
138FYN0.46870882
139LYN0.46272270
140RAF10.45673067
141MOS0.45566976
142MAPK70.45362204
143CDK120.45281628
144DAPK10.42041011
145PAK20.41662139
146MAP2K10.41148585
147CAMK40.41004863
148TAOK30.40666531
149LATS20.39956377
150ROCK10.38401252
151DYRK1B0.37346371
152ERBB30.37230070
153ERBB20.35762700

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.43692339
2Renin-angiotensin system_Homo sapiens_hsa046142.12975267
3Histidine metabolism_Homo sapiens_hsa003401.91220714
4Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.81714485
5Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.72413942
6Asthma_Homo sapiens_hsa053101.69911287
7Type II diabetes mellitus_Homo sapiens_hsa049301.66355274
8Long-term potentiation_Homo sapiens_hsa047201.59292950
9Circadian rhythm_Homo sapiens_hsa047101.54629265
10Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.52916466
11Insulin secretion_Homo sapiens_hsa049111.42137793
12Gastric acid secretion_Homo sapiens_hsa049711.40968979
13Aldosterone synthesis and secretion_Homo sapiens_hsa049251.39416507
14Circadian entrainment_Homo sapiens_hsa047131.39292454
15Sphingolipid signaling pathway_Homo sapiens_hsa040711.38218837
16Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.35399671
17Carbohydrate digestion and absorption_Homo sapiens_hsa049731.33830488
18Olfactory transduction_Homo sapiens_hsa047401.33183745
19Glioma_Homo sapiens_hsa052141.31375004
20Dorso-ventral axis formation_Homo sapiens_hsa043201.28032762
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.27972704
22FoxO signaling pathway_Homo sapiens_hsa040681.27264954
23mTOR signaling pathway_Homo sapiens_hsa041501.24728307
24Salivary secretion_Homo sapiens_hsa049701.23998158
25Renin secretion_Homo sapiens_hsa049241.20793935
26Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.20560923
27T cell receptor signaling pathway_Homo sapiens_hsa046601.19914677
28Glutamatergic synapse_Homo sapiens_hsa047241.16137669
29Amphetamine addiction_Homo sapiens_hsa050311.15534966
30Insulin resistance_Homo sapiens_hsa049311.15271531
31Estrogen signaling pathway_Homo sapiens_hsa049151.15127698
32Oxytocin signaling pathway_Homo sapiens_hsa049211.15105547
33Phosphatidylinositol signaling system_Homo sapiens_hsa040701.14754539
34Primary immunodeficiency_Homo sapiens_hsa053401.14366229
35Cholinergic synapse_Homo sapiens_hsa047251.14071316
36Jak-STAT signaling pathway_Homo sapiens_hsa046301.13581926
37Synaptic vesicle cycle_Homo sapiens_hsa047211.11315813
38Dopaminergic synapse_Homo sapiens_hsa047281.10793737
39Bile secretion_Homo sapiens_hsa049761.10523246
40GABAergic synapse_Homo sapiens_hsa047271.09895737
41Glucagon signaling pathway_Homo sapiens_hsa049221.09338649
42GnRH signaling pathway_Homo sapiens_hsa049121.06663907
43Arginine biosynthesis_Homo sapiens_hsa002201.04706005
44Dilated cardiomyopathy_Homo sapiens_hsa054141.02750190
45Insulin signaling pathway_Homo sapiens_hsa049101.02502008
46Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.02044608
47Neurotrophin signaling pathway_Homo sapiens_hsa047221.01350545
48Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.00467137
49Morphine addiction_Homo sapiens_hsa050320.99624207
50cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98449886
51Endometrial cancer_Homo sapiens_hsa052130.95489985
52VEGF signaling pathway_Homo sapiens_hsa043700.94993588
53Glycerophospholipid metabolism_Homo sapiens_hsa005640.93441824
54Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.92812468
55Thyroid hormone signaling pathway_Homo sapiens_hsa049190.92229913
56Adipocytokine signaling pathway_Homo sapiens_hsa049200.92183159
57Non-small cell lung cancer_Homo sapiens_hsa052230.91901351
58Chronic myeloid leukemia_Homo sapiens_hsa052200.91873574
59Measles_Homo sapiens_hsa051620.91567927
60Hematopoietic cell lineage_Homo sapiens_hsa046400.91112029
61SNARE interactions in vesicular transport_Homo sapiens_hsa041300.89404611
62Oocyte meiosis_Homo sapiens_hsa041140.88984612
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.88873043
64Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.88760227
65cAMP signaling pathway_Homo sapiens_hsa040240.86492849
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.85925110
67Gap junction_Homo sapiens_hsa045400.85853873
68Longevity regulating pathway - mammal_Homo sapiens_hsa042110.85819139
69Thyroid hormone synthesis_Homo sapiens_hsa049180.85146957
70Focal adhesion_Homo sapiens_hsa045100.84848248
71Proteoglycans in cancer_Homo sapiens_hsa052050.83678875
72Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.82515504
73Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.81102893
74Cocaine addiction_Homo sapiens_hsa050300.80577870
75AMPK signaling pathway_Homo sapiens_hsa041520.80572138
76ErbB signaling pathway_Homo sapiens_hsa040120.80338474
77Central carbon metabolism in cancer_Homo sapiens_hsa052300.78964556
78Platelet activation_Homo sapiens_hsa046110.78639854
79Pancreatic secretion_Homo sapiens_hsa049720.78490767
80Fatty acid biosynthesis_Homo sapiens_hsa000610.78358251
81Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77953454
82Hepatitis B_Homo sapiens_hsa051610.77894255
83Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.75437647
84Lysine degradation_Homo sapiens_hsa003100.75287509
85Long-term depression_Homo sapiens_hsa047300.74942069
86Leukocyte transendothelial migration_Homo sapiens_hsa046700.74289274
87Fatty acid degradation_Homo sapiens_hsa000710.74254103
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.73433577
89Regulation of autophagy_Homo sapiens_hsa041400.72937877
90Calcium signaling pathway_Homo sapiens_hsa040200.72465602
91Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.71793801
92Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.71246311
93Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.70623377
94Leishmaniasis_Homo sapiens_hsa051400.70442891
952-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.70213859
96Choline metabolism in cancer_Homo sapiens_hsa052310.69946067
97Hepatitis C_Homo sapiens_hsa051600.68850695
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.68825564
99Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.68134109
100Endocytosis_Homo sapiens_hsa041440.68113425
101Taste transduction_Homo sapiens_hsa047420.68078283
102Renal cell carcinoma_Homo sapiens_hsa052110.68021732
103RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.66917909
104Pancreatic cancer_Homo sapiens_hsa052120.66832086
105Nicotine addiction_Homo sapiens_hsa050330.66300304
106Vascular smooth muscle contraction_Homo sapiens_hsa042700.66176352
107PPAR signaling pathway_Homo sapiens_hsa033200.65996182
108Prolactin signaling pathway_Homo sapiens_hsa049170.65680438
109B cell receptor signaling pathway_Homo sapiens_hsa046620.65201990
110Inositol phosphate metabolism_Homo sapiens_hsa005620.63706711
111Melanogenesis_Homo sapiens_hsa049160.63313530
112Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63122126
113Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.61416128
114Fatty acid metabolism_Homo sapiens_hsa012120.60163199
115Toll-like receptor signaling pathway_Homo sapiens_hsa046200.60004270
116Amoebiasis_Homo sapiens_hsa051460.59695944
117AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59598647
118ABC transporters_Homo sapiens_hsa020100.58608041
119MAPK signaling pathway_Homo sapiens_hsa040100.57862436
120Tuberculosis_Homo sapiens_hsa051520.56305756
121Ras signaling pathway_Homo sapiens_hsa040140.55429757
122Adherens junction_Homo sapiens_hsa045200.54528951
123Rap1 signaling pathway_Homo sapiens_hsa040150.54025541
124Osteoclast differentiation_Homo sapiens_hsa043800.53844187
125Colorectal cancer_Homo sapiens_hsa052100.51414611
126Butanoate metabolism_Homo sapiens_hsa006500.49059414
127Glycerolipid metabolism_Homo sapiens_hsa005610.47685697
128Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.46678388
129Chemokine signaling pathway_Homo sapiens_hsa040620.46386434

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