DPPA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of retinoic acid receptor signaling pathway (GO:0048387)7.65352363
2purine nucleobase biosynthetic process (GO:0009113)6.69738279
3regulation of retinoic acid receptor signaling pathway (GO:0048385)6.61559176
4piRNA metabolic process (GO:0034587)6.41730376
5nucleobase biosynthetic process (GO:0046112)6.02054355
6ribosome assembly (GO:0042255)5.85724760
7mitotic metaphase plate congression (GO:0007080)5.65666269
8regulation of spindle organization (GO:0090224)4.99481501
9ribosome biogenesis (GO:0042254)4.95864840
10regulation of meiosis I (GO:0060631)4.93339573
11vitamin transmembrane transport (GO:0035461)4.81670148
12folic acid metabolic process (GO:0046655)4.81209756
13DNA replication checkpoint (GO:0000076)4.74083934
14regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.71601921
15male meiosis I (GO:0007141)4.49422159
16metaphase plate congression (GO:0051310)4.39254744
17rRNA modification (GO:0000154)4.38242075
18DNA methylation involved in gamete generation (GO:0043046)4.36931588
19proteasome assembly (GO:0043248)4.31960041
20regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.24899408
21regulation of mitotic spindle organization (GO:0060236)4.14118329
22transcription elongation from RNA polymerase III promoter (GO:0006385)4.05637077
23termination of RNA polymerase III transcription (GO:0006386)4.05637077
24positive regulation of chromosome segregation (GO:0051984)4.04670630
25transcription elongation from RNA polymerase I promoter (GO:0006362)4.04363729
26formation of translation preinitiation complex (GO:0001731)4.03628147
27folic acid transport (GO:0015884)4.00615766
28termination of RNA polymerase I transcription (GO:0006363)4.00615360
29anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.98834395
30transcription from mitochondrial promoter (GO:0006390)3.96527538
31blastocyst development (GO:0001824)3.95947424
32regulation of posttranscriptional gene silencing (GO:0060147)3.95738726
33regulation of gene silencing by miRNA (GO:0060964)3.95738726
34regulation of gene silencing by RNA (GO:0060966)3.95738726
35transcription from RNA polymerase I promoter (GO:0006360)3.95212035
36maturation of SSU-rRNA (GO:0030490)3.92178752
37chaperone-mediated protein transport (GO:0072321)3.91938517
38ribonucleoprotein complex biogenesis (GO:0022613)3.86570210
39male meiosis (GO:0007140)3.85347398
40meiosis I (GO:0007127)3.85080594
41histone exchange (GO:0043486)3.83230146
42positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.82591190
43regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.81725768
447-methylguanosine mRNA capping (GO:0006370)3.81005340
45protein localization to kinetochore (GO:0034501)3.79271475
46somatic hypermutation of immunoglobulin genes (GO:0016446)3.73146653
47somatic diversification of immune receptors via somatic mutation (GO:0002566)3.73146653
48DNA replication initiation (GO:0006270)3.71487220
49mitochondrial RNA metabolic process (GO:0000959)3.70496143
50synapsis (GO:0007129)3.69607797
517-methylguanosine RNA capping (GO:0009452)3.69302074
52RNA capping (GO:0036260)3.69302074
53spindle checkpoint (GO:0031577)3.69229362
54transcription initiation from RNA polymerase I promoter (GO:0006361)3.68177635
55maturation of 5.8S rRNA (GO:0000460)3.66422470
56mitotic nuclear envelope disassembly (GO:0007077)3.65738223
57establishment of integrated proviral latency (GO:0075713)3.64720680
58DNA deamination (GO:0045006)3.62028647
59negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.61667302
60rRNA processing (GO:0006364)3.60654654
61cell fate commitment involved in formation of primary germ layer (GO:0060795)3.60176911
62regulation of translation in response to stress (GO:0043555)3.58243532
63mitotic spindle checkpoint (GO:0071174)3.56374172
64spliceosomal snRNP assembly (GO:0000387)3.53588807
65GMP metabolic process (GO:0046037)3.53212503
66meiotic chromosome segregation (GO:0045132)3.53117836
67establishment of chromosome localization (GO:0051303)3.52738547
68regulation of chromosome segregation (GO:0051983)3.50698594
69positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.50372014
70rRNA metabolic process (GO:0016072)3.50234313
71intestinal epithelial cell development (GO:0060576)3.48133536
72negative regulation of chromosome segregation (GO:0051985)3.47396780
73resolution of meiotic recombination intermediates (GO:0000712)3.46312022
74negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.42711846
75negative regulation of sister chromatid segregation (GO:0033046)3.42711846
76negative regulation of mitotic sister chromatid separation (GO:2000816)3.42711846
77negative regulation of mitotic sister chromatid segregation (GO:0033048)3.42711846
78ribosomal small subunit assembly (GO:0000028)3.40684638
79membrane disassembly (GO:0030397)3.39935332
80nuclear envelope disassembly (GO:0051081)3.39935332
81rRNA methylation (GO:0031167)3.39079849
82mitotic spindle assembly checkpoint (GO:0007094)3.38960677
83protein K6-linked ubiquitination (GO:0085020)3.38342029
84protein localization to chromosome, centromeric region (GO:0071459)3.34396360
85negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.33892967
86L-methionine salvage (GO:0071267)3.33884001
87L-methionine biosynthetic process (GO:0071265)3.33884001
88amino acid salvage (GO:0043102)3.33884001
89spindle assembly checkpoint (GO:0071173)3.33001179
90pantothenate metabolic process (GO:0015939)3.32757278
91pseudouridine synthesis (GO:0001522)3.31901274
92regulation of nuclear cell cycle DNA replication (GO:0033262)3.31678882
93regulation of mitotic metaphase/anaphase transition (GO:0030071)3.31332713
94regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.30864971
95regulation of mitotic spindle checkpoint (GO:1903504)3.30864971
96mitotic sister chromatid segregation (GO:0000070)3.30812223
97CENP-A containing nucleosome assembly (GO:0034080)3.27429165
98positive regulation of ligase activity (GO:0051351)3.26801166
99attachment of spindle microtubules to kinetochore (GO:0008608)3.26142855
100DNA replication-dependent nucleosome assembly (GO:0006335)3.25040637
101DNA replication-dependent nucleosome organization (GO:0034723)3.25040637
102negative regulation of ligase activity (GO:0051352)3.24991963
103negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.24991963
104regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.24776742
105DNA strand elongation involved in DNA replication (GO:0006271)3.22408474
106ribosomal large subunit biogenesis (GO:0042273)3.22217877
107establishment of protein localization to mitochondrial membrane (GO:0090151)3.22108234
108glycine metabolic process (GO:0006544)3.18082729
109regulation of centriole replication (GO:0046599)3.16648111
110chromatin remodeling at centromere (GO:0031055)3.15907507
111regulation of centrosome cycle (GO:0046605)3.15408647
112IMP metabolic process (GO:0046040)3.14914725
113kinetochore assembly (GO:0051382)3.14357309
114IMP biosynthetic process (GO:0006188)3.14286570
115spindle assembly involved in mitosis (GO:0090307)3.14240249
116gonadal mesoderm development (GO:0007506)3.13237048
117DNA replication-independent nucleosome organization (GO:0034724)3.12495932
118DNA replication-independent nucleosome assembly (GO:0006336)3.12495932
119regulation of helicase activity (GO:0051095)3.12042672
120G1/S transition of mitotic cell cycle (GO:0000082)3.11810491
121cell cycle G1/S phase transition (GO:0044843)3.11810491
122regulation of ubiquitin-protein transferase activity (GO:0051438)3.11655972
123DNA-templated transcription, elongation (GO:0006354)3.11477159
124regulation of mitochondrial translation (GO:0070129)3.09760917
125regulation of mitotic sister chromatid separation (GO:0010965)3.09412738
126regulation of mitotic sister chromatid segregation (GO:0033047)3.09412738
127regulation of sister chromatid segregation (GO:0033045)3.09412738
128transcription-coupled nucleotide-excision repair (GO:0006283)3.09315420
129transcription elongation from RNA polymerase II promoter (GO:0006368)3.09073639
130nuclear pore organization (GO:0006999)3.08293175
131regulation of double-strand break repair via homologous recombination (GO:0010569)3.07863440
132histone-serine phosphorylation (GO:0035404)3.07854727
133negative regulation of meiosis (GO:0045835)3.05902281
134protein-cofactor linkage (GO:0018065)3.03297893
135meiotic nuclear division (GO:0007126)3.02483099
136regulation of DNA methylation (GO:0044030)3.01032697
137DNA catabolic process, exonucleolytic (GO:0000738)2.93706762
138gene silencing by RNA (GO:0031047)2.93430851
139positive regulation of SMAD protein import into nucleus (GO:0060391)2.91616876
140DNA strand elongation (GO:0022616)2.89066460
141protein complex localization (GO:0031503)2.88529019
142respiratory chain complex IV assembly (GO:0008535)2.87873048
143exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.86470971
144chromosome organization involved in meiosis (GO:0070192)2.86181919
145negative regulation of DNA-dependent DNA replication (GO:2000104)2.86155526
146telomere maintenance via semi-conservative replication (GO:0032201)2.81848940
147reciprocal DNA recombination (GO:0035825)2.80918429
148reciprocal meiotic recombination (GO:0007131)2.80918429
149meiotic cell cycle process (GO:1903046)2.80395252
150meiotic cell cycle (GO:0051321)2.76689169
151DNA double-strand break processing (GO:0000729)2.74887412
152nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.73979614
153DNA alkylation (GO:0006305)2.73874499
154DNA methylation (GO:0006306)2.73874499
155DNA damage response, detection of DNA damage (GO:0042769)2.72502693
156RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.71364000
157tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.71364000
158ventricular cardiac muscle cell development (GO:0055015)2.71176086
159establishment of viral latency (GO:0019043)2.70829029

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.39212830
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.85013020
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.01365501
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.86663726
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.48519364
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.37530839
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.33422852
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.22335075
9MYC_19079543_ChIP-ChIP_MESCs_Mouse3.17087981
10E2F4_17652178_ChIP-ChIP_JURKAT_Human3.06359262
11EST1_17652178_ChIP-ChIP_JURKAT_Human3.05873543
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.99452376
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.94602940
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.85800761
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.83348430
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.81445000
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.73363202
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.55035632
19AR_21909140_ChIP-Seq_LNCAP_Human2.43747604
20ZNF274_21170338_ChIP-Seq_K562_Hela2.43373690
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.41989635
22* NANOG_18555785_ChIP-Seq_MESCs_Mouse2.37945342
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.31824439
24VDR_23849224_ChIP-Seq_CD4+_Human2.31381958
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.22708537
26POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.17223299
27NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.15393904
28XRN2_22483619_ChIP-Seq_HELA_Human2.11251963
29POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.02878874
30* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.00302904
31KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.99105703
32MYCN_18555785_ChIP-Seq_MESCs_Mouse1.97220574
33HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.90343236
34GABP_19822575_ChIP-Seq_HepG2_Human1.90301088
35HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.88098050
36SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.88031852
37* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.85828975
38YY1_21170310_ChIP-Seq_MESCs_Mouse1.84816988
39VDR_22108803_ChIP-Seq_LS180_Human1.80904996
40DCP1A_22483619_ChIP-Seq_HELA_Human1.77879750
41FOXP3_21729870_ChIP-Seq_TREG_Human1.77763330
42NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.77145521
43THAP11_20581084_ChIP-Seq_MESCs_Mouse1.72350273
44SALL1_21062744_ChIP-ChIP_HESCs_Human1.65380022
45POU5F1_16153702_ChIP-ChIP_HESCs_Human1.64488920
46ZNF263_19887448_ChIP-Seq_K562_Human1.64472800
47MYC_18940864_ChIP-ChIP_HL60_Human1.62396993
48NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.61643929
49TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.61523995
50E2F1_21310950_ChIP-Seq_MCF-7_Human1.60129385
51YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.58957738
52* SOX2_16153702_ChIP-ChIP_HESCs_Human1.58830946
53TTF2_22483619_ChIP-Seq_HELA_Human1.58108645
54STAT3_1855785_ChIP-Seq_MESCs_Mouse1.57252699
55PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55658547
56GATA1_26923725_Chip-Seq_HPCs_Mouse1.53172718
57KDM5A_27292631_Chip-Seq_BREAST_Human1.52689287
58* NANOG_16153702_ChIP-ChIP_HESCs_Human1.52029684
59IGF1R_20145208_ChIP-Seq_DFB_Human1.51133516
60POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.49086308
61KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.46624149
62KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.46624149
63KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.46624149
64IRF1_19129219_ChIP-ChIP_H3396_Human1.42867448
65KLF4_18555785_ChIP-Seq_MESCs_Mouse1.40715234
66HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.39379998
67ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.39113806
68FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.37209440
69MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.35455903
70SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.33076167
71NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.32421905
72FLI1_27457419_Chip-Seq_LIVER_Mouse1.32360235
73KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.31054003
74SRF_21415370_ChIP-Seq_HL-1_Mouse1.30241646
75TCF3_18692474_ChIP-Seq_MEFs_Mouse1.29104275
76ELK1_19687146_ChIP-ChIP_HELA_Human1.27761106
77CIITA_25753668_ChIP-Seq_RAJI_Human1.26589932
78ZFX_18555785_ChIP-Seq_MESCs_Mouse1.24968049
79CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.22466646
80NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.18777599
81RBPJ_22232070_ChIP-Seq_NCS_Mouse1.18123881
82PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.17994471
83* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.16565019
84SOX2_18555785_ChIP-Seq_MESCs_Mouse1.14486043
85NANOG_21062744_ChIP-ChIP_HESCs_Human1.14271240
86PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13687439
87ELK1_22589737_ChIP-Seq_MCF10A_Human1.12159019
88GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11171007
89TP63_19390658_ChIP-ChIP_HaCaT_Human1.10376063
90ELF1_17652178_ChIP-ChIP_JURKAT_Human1.08766379
91SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.08753661
92* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.08139007
93KAP1_22055183_ChIP-Seq_ESCs_Mouse1.07240113
94EGR1_19374776_ChIP-ChIP_THP-1_Human1.07171422
95CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.06044910
96KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.04394151
97EWS_26573619_Chip-Seq_HEK293_Human1.04027241
98OCT4_18692474_ChIP-Seq_MEFs_Mouse1.03862657
99CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.02492325
100DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.02462916
101SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.01046764
102BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.00229495
103* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.00225139
104HOXB4_20404135_ChIP-ChIP_EML_Mouse0.98885994
105* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.98161828
106* TCF3_18692474_ChIP-Seq_MESCs_Mouse0.97062216
107TP53_22573176_ChIP-Seq_HFKS_Human0.96003604
108KAP1_27257070_Chip-Seq_ESCs_Mouse0.93831585
109NOTCH1_21737748_ChIP-Seq_TLL_Human0.92882706
110SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.92784872
111TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.91957312
112PCGF2_27294783_Chip-Seq_ESCs_Mouse0.91881112
113* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.91762507
114E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.91487266
115CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.90840151
116SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.88675484
117TFEB_21752829_ChIP-Seq_HELA_Human0.88375774
118CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.85448014
119* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.84301211
120CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.83603642
121HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.82521110
122P300_19829295_ChIP-Seq_ESCs_Human0.79428544
123EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.77906315
124FUS_26573619_Chip-Seq_HEK293_Human0.76844020
125HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.74941273
126SOX17_20123909_ChIP-Seq_XEN_Mouse0.71856684
127GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.71728470
128ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.70883377
129ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.69644973

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.87381227
2MP0003111_abnormal_nucleus_morphology5.34585678
3MP0003718_maternal_effect4.69116784
4MP0004957_abnormal_blastocyst_morpholog4.60784992
5MP0010094_abnormal_chromosome_stability4.20149225
6MP0003077_abnormal_cell_cycle3.88626945
7MP0008260_abnormal_autophagy3.25640676
8MP0008057_abnormal_DNA_replication3.21898199
9MP0008058_abnormal_DNA_repair3.20213921
10MP0002254_reproductive_system_inflammat2.86894535
11MP0008932_abnormal_embryonic_tissue2.64894018
12MP0003786_premature_aging2.64302073
13MP0001730_embryonic_growth_arrest2.57098739
14MP0009840_abnormal_foam_cell2.57017936
15MP0003123_paternal_imprinting2.51980444
16MP0003890_abnormal_embryonic-extraembry2.37664482
17MP0003878_abnormal_ear_physiology2.24351564
18MP0005377_hearing/vestibular/ear_phenot2.24351564
19MP0008007_abnormal_cellular_replicative2.21655012
20MP0000350_abnormal_cell_proliferation2.15197623
21MP0008877_abnormal_DNA_methylation2.13334335
22MP0005380_embryogenesis_phenotype1.98238430
23MP0001672_abnormal_embryogenesis/_devel1.98238430
24MP0003806_abnormal_nucleotide_metabolis1.85634803
25MP0001986_abnormal_taste_sensitivity1.79449662
26MP0005395_other_phenotype1.77084838
27MP0010307_abnormal_tumor_latency1.76604801
28MP0003315_abnormal_perineum_morphology1.68070546
29MP0003984_embryonic_growth_retardation1.66647845
30MP0001697_abnormal_embryo_size1.63303483
31MP0002088_abnormal_embryonic_growth/wei1.63141364
32MP0002080_prenatal_lethality1.62260525
33MP0003567_abnormal_fetal_cardiomyocyte1.62249237
34MP0001661_extended_life_span1.58167526
35MP0004133_heterotaxia1.53783833
36MP0002210_abnormal_sex_determination1.49651771
37MP0002085_abnormal_embryonic_tissue1.46648801
38MP0003941_abnormal_skin_development1.41064148
39MP0001542_abnormal_bone_strength1.38679326
40MP0005451_abnormal_body_composition1.37233914
41MP0002796_impaired_skin_barrier1.34827544
42MP0001145_abnormal_male_reproductive1.31003896
43MP0002653_abnormal_ependyma_morphology1.30273938
44MP0002086_abnormal_extraembryonic_tissu1.30067220
45MP0002084_abnormal_developmental_patter1.27095872
46MP0005410_abnormal_fertilization1.26570237
47MP0001929_abnormal_gametogenesis1.23390328
48MP0009379_abnormal_foot_pigmentation1.22699088
49MP0003221_abnormal_cardiomyocyte_apopto1.22107401
50MP0000750_abnormal_muscle_regeneration1.18366901
51MP0002736_abnormal_nociception_after1.18308855
52MP0003938_abnormal_ear_development1.17144925
53MP0003787_abnormal_imprinting1.16670325
54MP0000313_abnormal_cell_death1.16667137
55MP0000653_abnormal_sex_gland1.16554814
56MP0006292_abnormal_olfactory_placode1.16448946
57MP0009333_abnormal_splenocyte_physiolog1.13634939
58MP0002396_abnormal_hematopoietic_system1.08209833
59MP0001177_atelectasis1.05433710
60MP0004215_abnormal_myocardial_fiber1.03873787
61MP0009672_abnormal_birth_weight1.02711930
62MP0005389_reproductive_system_phenotype1.02331426
63MP0005423_abnormal_somatic_nervous1.02098840
64MP0002160_abnormal_reproductive_system1.02016458
65MP0000358_abnormal_cell_content/1.00643532
66MP0001293_anophthalmia0.99255229
67MP0003136_yellow_coat_color0.97682195
68MP0004233_abnormal_muscle_weight0.96702360
69MP0010352_gastrointestinal_tract_polyps0.96660260
70MP0004019_abnormal_vitamin_homeostasis0.95299351
71MP0003119_abnormal_digestive_system0.94369880
72MP0005621_abnormal_cell_physiology0.93884591
73MP0002277_abnormal_respiratory_mucosa0.92755726
74MP0005384_cellular_phenotype0.91207050
75MP0004197_abnormal_fetal_growth/weight/0.90918263
76MP0003699_abnormal_female_reproductive0.90768648
77MP0002697_abnormal_eye_size0.90673978
78MP0003937_abnormal_limbs/digits/tail_de0.90563443
79MP0002019_abnormal_tumor_incidence0.87581229
80MP0002163_abnormal_gland_morphology0.87462965
81MP0005551_abnormal_eye_electrophysiolog0.87077149
82MP0006035_abnormal_mitochondrial_morpho0.86375429
83MP0009697_abnormal_copulation0.85798414
84MP0001119_abnormal_female_reproductive0.83709365
85MP0001485_abnormal_pinna_reflex0.83008130
86MP0001188_hyperpigmentation0.82611458
87MP0000627_abnormal_mammary_gland0.80994746
88MP0005647_abnormal_sex_gland0.79631034
89MP0005501_abnormal_skin_physiology0.79477776
90MP0000015_abnormal_ear_pigmentation0.79399251
91MP0003950_abnormal_plasma_membrane0.79071208
92MP0000490_abnormal_crypts_of0.78531141
93MP0002132_abnormal_respiratory_system0.78000603
94MP0001756_abnormal_urination0.77751421
95MP0000428_abnormal_craniofacial_morphol0.76795684
96MP0002161_abnormal_fertility/fecundity0.76164337
97MP0008872_abnormal_physiological_respon0.75692119
98MP0004084_abnormal_cardiac_muscle0.73386185
99MP0003186_abnormal_redox_activity0.73358461
100MP0010030_abnormal_orbit_morphology0.73318320
101MP0004885_abnormal_endolymph0.73242812
102MP0001919_abnormal_reproductive_system0.72920084
103MP0006276_abnormal_autonomic_nervous0.72438938
104MP0001324_abnormal_eye_pigmentation0.72309708
105MP0000579_abnormal_nail_morphology0.71835664
106MP0009703_decreased_birth_body0.71791130
107MP0003646_muscle_fatigue0.71609242
108MP0003936_abnormal_reproductive_system0.70757651
109MP0002090_abnormal_vision0.70586740
110MP0005379_endocrine/exocrine_gland_phen0.70306433
111MP0003698_abnormal_male_reproductive0.69599349
112MP0000372_irregular_coat_pigmentation0.68688920
113MP0001545_abnormal_hematopoietic_system0.68456844
114MP0005397_hematopoietic_system_phenotyp0.68456844
115MP0002102_abnormal_ear_morphology0.68453733
116MP0005075_abnormal_melanosome_morpholog0.68267882
117MP0010368_abnormal_lymphatic_system0.67540501
118MP0001346_abnormal_lacrimal_gland0.67339887
119MP0002111_abnormal_tail_morphology0.66507261
120MP0002269_muscular_atrophy0.64463901
121MP0001764_abnormal_homeostasis0.63256668
122MP0005076_abnormal_cell_differentiation0.62162220
123MP0005332_abnormal_amino_acid0.61847528
124MP0004264_abnormal_extraembryonic_tissu0.60665778
125MP0000647_abnormal_sebaceous_gland0.60396354
126MP0000747_muscle_weakness0.59303444
127MP0002127_abnormal_cardiovascular_syste0.58017039
128MP0002092_abnormal_eye_morphology0.57997563
129MP0006036_abnormal_mitochondrial_physio0.55493002
130MP0001727_abnormal_embryo_implantation0.55423939
131MP0008995_early_reproductive_senescence0.49473851
132MP0003121_genomic_imprinting0.47299124
133MP0000516_abnormal_urinary_system0.45745294
134MP0005367_renal/urinary_system_phenotyp0.45745294
135MP0001286_abnormal_eye_development0.44813951

Predicted human phenotypes

RankGene SetZ-score
1Breast hypoplasia (HP:0003187)6.07107240
2Birth length less than 3rd percentile (HP:0003561)6.06424685
3Carpal bone hypoplasia (HP:0001498)5.10933658
4Cerebral hypomyelination (HP:0006808)4.67373601
5Hyperglycinemia (HP:0002154)4.53224774
6Impulsivity (HP:0100710)4.52722472
7Rough bone trabeculation (HP:0100670)4.25108421
8Patellar aplasia (HP:0006443)3.88329120
9Aplasia/Hypoplasia of the patella (HP:0006498)3.85915262
10Hyperglycinuria (HP:0003108)3.78862749
11Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.72314023
12Abnormality of the labia minora (HP:0012880)3.64513715
13Absent radius (HP:0003974)3.46610833
14Abnormality of the anterior horn cell (HP:0006802)3.37033605
15Degeneration of anterior horn cells (HP:0002398)3.37033605
16Ureteral duplication (HP:0000073)3.36329599
17Progressive muscle weakness (HP:0003323)3.29271460
18Gout (HP:0001997)3.27910564
19Aplasia involving forearm bones (HP:0009822)3.25733796
20Absent forearm bone (HP:0003953)3.25733796
21Premature ovarian failure (HP:0008209)3.14694649
22Bilateral microphthalmos (HP:0007633)3.13945138
23Abnormal trabecular bone morphology (HP:0100671)3.13190243
24Abnormality of the umbilical cord (HP:0010881)3.12578490
25Abnormality of serine family amino acid metabolism (HP:0010894)3.09089675
26Abnormality of glycine metabolism (HP:0010895)3.09089675
27Fused cervical vertebrae (HP:0002949)3.01678016
28Colon cancer (HP:0003003)3.00061381
29Aplasia/Hypoplasia involving the musculature (HP:0001460)2.99557208
30Reticulocytopenia (HP:0001896)2.98366243
31Secondary amenorrhea (HP:0000869)2.96886065
32CNS hypomyelination (HP:0003429)2.90084091
33Stenosis of the external auditory canal (HP:0000402)2.86503052
34Entropion (HP:0000621)2.86403684
35Oral leukoplakia (HP:0002745)2.84381807
36Aplasia/Hypoplasia of the fovea (HP:0008060)2.73301605
37Hypoplasia of the fovea (HP:0007750)2.73301605
38Abnormality of serum amino acid levels (HP:0003112)2.73284709
39Areflexia of lower limbs (HP:0002522)2.72663668
40Hypoplasia of the capital femoral epiphysis (HP:0003090)2.67614417
41Multiple enchondromatosis (HP:0005701)2.65162486
42Meckel diverticulum (HP:0002245)2.63483878
43Microvesicular hepatic steatosis (HP:0001414)2.63246305
44Abnormality of the preputium (HP:0100587)2.57178948
45Sparse lateral eyebrow (HP:0005338)2.57008014
46Septo-optic dysplasia (HP:0100842)2.56211885
47Death in infancy (HP:0001522)2.55039238
48Tetraplegia (HP:0002445)2.54567032
49Chromosomal breakage induced by crosslinking agents (HP:0003221)2.52886256
50Megaloblastic anemia (HP:0001889)2.46339685
51Abnormality of alanine metabolism (HP:0010916)2.46238297
52Hyperalaninemia (HP:0003348)2.46238297
53Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.46238297
54Abnormality of the ileum (HP:0001549)2.41815086
55Breast aplasia (HP:0100783)2.40852979
56Irregular epiphyses (HP:0010582)2.40255860
57Absent hand (HP:0004050)2.39857168
58Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.39022303
59Personality changes (HP:0000751)2.38682553
60Oligodactyly (hands) (HP:0001180)2.38469178
61Aplasia/hypoplasia of the humerus (HP:0006507)2.38269517
62Atrioventricular block (HP:0001678)2.37609678
63Ependymoma (HP:0002888)2.35599028
64Sparse eyelashes (HP:0000653)2.35446784
65Acute necrotizing encephalopathy (HP:0006965)2.34522942
66Pendular nystagmus (HP:0012043)2.34451955
67Chromsome breakage (HP:0040012)2.33834161
68Pustule (HP:0200039)2.33094136
69Horseshoe kidney (HP:0000085)2.30756010
70Microretrognathia (HP:0000308)2.28690918
71Spinal muscular atrophy (HP:0007269)2.27773406
72Aplasia/Hypoplasia of the breasts (HP:0010311)2.26884819
73Delusions (HP:0000746)2.25981742
74Abnormal spermatogenesis (HP:0008669)2.25203570
75Increased CSF lactate (HP:0002490)2.24948809
76Chronic bronchitis (HP:0004469)2.24388095
77Muscle fiber splitting (HP:0003555)2.23652893
78Acute encephalopathy (HP:0006846)2.23184948
79Abnormality of the fovea (HP:0000493)2.22309683
80Abnormal lung lobation (HP:0002101)2.20886930
81Reduced antithrombin III activity (HP:0001976)2.19996509
82Abnormality of chromosome stability (HP:0003220)2.19571667
83Abnormality of cells of the erythroid lineage (HP:0012130)2.19382926
84Bone marrow hypocellularity (HP:0005528)2.18778395
85Atrophy/Degeneration involving motor neurons (HP:0007373)2.17682712
86Shawl scrotum (HP:0000049)2.17614258
87Neoplasm of the pancreas (HP:0002894)2.17608232
88Oligodactyly (HP:0012165)2.16330232
89Abnormal number of erythroid precursors (HP:0012131)2.15351496
90Agnosia (HP:0010524)2.14815721
91Triphalangeal thumb (HP:0001199)2.12537787
92Selective tooth agenesis (HP:0001592)2.12283263
93Ectopic kidney (HP:0000086)2.11573620
94Abnormality of the septum pellucidum (HP:0007375)2.09310753
95Aplasia/Hypoplasia of the uvula (HP:0010293)2.09207155
96Pelvic girdle muscle weakness (HP:0003749)2.07717937
97Stillbirth (HP:0003826)2.05962329
98Congenital, generalized hypertrichosis (HP:0004540)2.05681724
99Pancreatic fibrosis (HP:0100732)2.05180168
100Aplasia/Hypoplasia of the earlobes (HP:0009906)2.05168505
101Absent epiphyses (HP:0010577)2.04244934
102Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.04244934
103Aplasia/hypoplasia of the uterus (HP:0008684)2.03849471
104Abnormality of the distal phalanges of the toes (HP:0010182)2.03783928
105Biliary tract neoplasm (HP:0100574)2.03633786
106Facial hemangioma (HP:0000329)2.02830108
107Premature graying of hair (HP:0002216)2.02497438
108Increased serum lactate (HP:0002151)2.02429121
109Trismus (HP:0000211)2.01449024
110Prolonged neonatal jaundice (HP:0006579)2.01115995
111Abdominal situs inversus (HP:0003363)2.00653955
112Abnormality of abdominal situs (HP:0011620)2.00653955
113Shoulder girdle muscle weakness (HP:0003547)2.00430954
114Abnormalities of placenta or umbilical cord (HP:0001194)2.00068795
115Absent thumb (HP:0009777)1.99286714
116Small epiphyses (HP:0010585)1.99248123
117Macrocytic anemia (HP:0001972)1.97479351
118Bundle branch block (HP:0011710)1.97405067
119Dysautonomia (HP:0002459)1.96601668
120Patent foramen ovale (HP:0001655)1.95540088
121Small intestinal stenosis (HP:0012848)1.95518994
122Duodenal stenosis (HP:0100867)1.95518994
123Abnormality of the proximal phalanges of the hand (HP:0009834)1.94688367
124Hypomagnesemia (HP:0002917)1.94445207
125Abnormal mitochondria in muscle tissue (HP:0008316)1.94264134
126Astrocytoma (HP:0009592)1.94192069
127Abnormality of the astrocytes (HP:0100707)1.94192069
128Segmental peripheral demyelination/remyelination (HP:0003481)1.93831191
129Abnormality of the renal collecting system (HP:0004742)1.93614173
130Postnatal microcephaly (HP:0005484)1.91847260
131Absent septum pellucidum (HP:0001331)1.91546577
132Supernumerary spleens (HP:0009799)1.88980449
133Facial cleft (HP:0002006)1.88608500
134Sloping forehead (HP:0000340)1.87909808
135Duplicated collecting system (HP:0000081)1.87868370
136Abnormality of the duodenum (HP:0002246)1.87568116
137Ventricular fibrillation (HP:0001663)1.86576506
138Rhabdomyosarcoma (HP:0002859)1.84850623
139Progressive macrocephaly (HP:0004481)1.84089408
140Methylmalonic acidemia (HP:0002912)1.83996593
141Cellular immunodeficiency (HP:0005374)1.83818587
142Hypoglycemic seizures (HP:0002173)1.83575737
143Cerebral edema (HP:0002181)1.83500546
144Increased hepatocellular lipid droplets (HP:0006565)1.83410248
145Glioma (HP:0009733)1.82213935
146Hyperinsulinemic hypoglycemia (HP:0000825)1.82144673
147Mitochondrial inheritance (HP:0001427)1.82097811
148Neoplasm of the colon (HP:0100273)1.81633994
149Split foot (HP:0001839)1.81617819
150Lipid accumulation in hepatocytes (HP:0006561)1.80688768
151Small hand (HP:0200055)1.79727485
152Methylmalonic aciduria (HP:0012120)1.79213920
153Aplasia/Hypoplasia of the macula (HP:0008059)1.78281355
154Asplenia (HP:0001746)1.77363526
155Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.77224923
156Cerebellar dysplasia (HP:0007033)1.74026198
157Abnormality of aspartate family amino acid metabolism (HP:0010899)1.73716537
158Pancreatic cysts (HP:0001737)1.72611353
159Aplasia/Hypoplasia of the spleen (HP:0010451)1.72464973
160Clubbing of toes (HP:0100760)1.71940069
161Abnormal glycosylation (HP:0012345)1.71569213
162Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.71569213
163Abnormal protein N-linked glycosylation (HP:0012347)1.71569213
164Abnormal protein glycosylation (HP:0012346)1.71569213

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB16.58186762
2WEE15.20533554
3PBK4.69708560
4AKT33.60090815
5PLK43.26862319
6EIF2AK13.17022911
7TSSK63.06778604
8CDK192.88405491
9PNCK2.76097675
10NEK22.68828302
11EPHA22.67031968
12VRK22.64001108
13STK162.61460549
14NEK12.42093165
15TTK2.40612377
16TAF12.37367511
17SRPK12.34472652
18MST42.31315559
19BRSK22.26578220
20PLK12.08926228
21PLK32.07661098
22ZAK1.89252946
23MKNK21.87799112
24EIF2AK31.82829153
25ACVR1B1.81324582
26CDC71.80119339
27TRIM281.72128322
28MKNK11.67264893
29INSRR1.58963875
30BRSK11.52956471
31DYRK31.50112739
32CHEK21.40657883
33NME21.39616394
34PDK31.34928879
35PDK41.34928879
36IRAK31.34921388
37OXSR11.33498352
38ARAF1.32437798
39STK38L1.28781675
40BRAF1.28154560
41AURKB1.27323041
42CCNB11.26406695
43PDK21.25539801
44AURKA1.25432716
45PINK11.24856430
46MUSK1.24700663
47LATS21.22456328
48TNIK1.21079092
49STK391.17070072
50TESK21.14973158
51CDK71.02508842
52STK30.98816076
53ALK0.94998703
54CHEK10.94009593
55VRK10.93126201
56MAP3K80.92672476
57GRK10.92175210
58PRKCI0.89692983
59ERBB40.86269962
60ATR0.85825001
61CDK40.84976395
62WNK40.83684054
63BMPR1B0.82055406
64EIF2AK20.79008963
65RPS6KA40.78911045
66PAK10.70801318
67CDK20.69969576
68PIM20.67156717
69RPS6KB20.65734881
70NME10.63548848
71PLK20.57981589
72MAP4K20.56431112
73CSNK1E0.54454658
74STK40.53761981
75CSNK2A10.53481663
76CSNK2A20.52708938
77CDK10.51883113
78TIE10.50734873
79DYRK20.49477929
80CSNK1G30.49346439
81ATM0.47488870
82MELK0.47372335
83PIM10.46915858
84FRK0.46011319
85STK240.44860240
86MAP3K90.44493944
87BCKDK0.44217449
88TLK10.41592247
89RAF10.41257842
90FGFR10.38616272
91CDK30.36895469
92BMX0.35606565
93CSNK1G10.35112673
94ADRBK20.34953652
95RPS6KA50.34291067
96WNK30.33392561
97STK100.31365609
98PAK40.31258395
99CSNK1A1L0.30165131
100MTOR0.29229136
101RPS6KB10.28953925
102PRKAA10.28765407
103ABL20.28599242
104RPS6KA10.28529356
105STK380.28500236
106KDR0.25942285
107TGFBR10.25053767
108PRKCG0.24018781
109MARK10.23829887
110FGFR20.23625987
111PRKCE0.23037340
112CDK120.22903910
113CSNK1A10.21432089
114CSNK1G20.20761058
115PASK0.19654507
116AKT20.19553534
117MAPK100.17673524
118NUAK10.16605077
119MAP2K20.15866672
120NEK60.15761953
121PRKDC0.14192961
122GSK3B0.13936092
123LATS10.13845186
124CSNK1D0.11897463
125BRD40.11216401
126MAPK90.10391526
127MAPK140.10179104
128MARK30.09837570

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.35622521
2RNA polymerase_Homo sapiens_hsa030204.59959633
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.59347238
4Proteasome_Homo sapiens_hsa030503.99415064
5RNA transport_Homo sapiens_hsa030133.43237865
6DNA replication_Homo sapiens_hsa030303.13839041
7Mismatch repair_Homo sapiens_hsa034302.79516267
8Spliceosome_Homo sapiens_hsa030402.71262514
9Pyrimidine metabolism_Homo sapiens_hsa002402.60631022
10Cell cycle_Homo sapiens_hsa041102.59829096
11Folate biosynthesis_Homo sapiens_hsa007902.42321579
12Regulation of autophagy_Homo sapiens_hsa041402.30628443
13Homologous recombination_Homo sapiens_hsa034402.25403957
14Nucleotide excision repair_Homo sapiens_hsa034202.23958460
15Basal transcription factors_Homo sapiens_hsa030222.21777729
16Base excision repair_Homo sapiens_hsa034102.08348494
17Ribosome_Homo sapiens_hsa030102.01495838
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.86941783
19Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.83310355
20Fanconi anemia pathway_Homo sapiens_hsa034601.83062260
21Propanoate metabolism_Homo sapiens_hsa006401.75130809
22Oxidative phosphorylation_Homo sapiens_hsa001901.74980132
23p53 signaling pathway_Homo sapiens_hsa041151.74905163
24Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.72387107
25Pentose phosphate pathway_Homo sapiens_hsa000301.71368425
26Purine metabolism_Homo sapiens_hsa002301.69053722
27One carbon pool by folate_Homo sapiens_hsa006701.66927662
28Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.66708533
29Parkinsons disease_Homo sapiens_hsa050121.64583747
30Protein export_Homo sapiens_hsa030601.49106645
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.45879189
32Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.45375036
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.41092218
34Pyruvate metabolism_Homo sapiens_hsa006201.40062842
35Glycerophospholipid metabolism_Homo sapiens_hsa005641.38758980
36Oocyte meiosis_Homo sapiens_hsa041141.38315053
37Vitamin digestion and absorption_Homo sapiens_hsa049771.34146588
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.33178318
39RNA degradation_Homo sapiens_hsa030181.28711519
40Epstein-Barr virus infection_Homo sapiens_hsa051691.26097106
41Fatty acid elongation_Homo sapiens_hsa000621.19319740
42mRNA surveillance pathway_Homo sapiens_hsa030151.19193736
43Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.16672412
44Biosynthesis of amino acids_Homo sapiens_hsa012301.16035999
45Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.14798944
46Fructose and mannose metabolism_Homo sapiens_hsa000511.04880169
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.01518838
48Non-homologous end-joining_Homo sapiens_hsa034500.97411500
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.88407350
50Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.87826506
512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.85037426
52Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.80392286
53Steroid biosynthesis_Homo sapiens_hsa001000.75967229
54Selenocompound metabolism_Homo sapiens_hsa004500.74747845
55Phototransduction_Homo sapiens_hsa047440.74325203
56Alzheimers disease_Homo sapiens_hsa050100.70655570
57Carbon metabolism_Homo sapiens_hsa012000.70535824
58Maturity onset diabetes of the young_Homo sapiens_hsa049500.65487936
59Sulfur relay system_Homo sapiens_hsa041220.64702930
60Nitrogen metabolism_Homo sapiens_hsa009100.63900683
61Glutathione metabolism_Homo sapiens_hsa004800.63339196
62Fatty acid degradation_Homo sapiens_hsa000710.60922898
63Cyanoamino acid metabolism_Homo sapiens_hsa004600.60068315
64Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.59604713
65Collecting duct acid secretion_Homo sapiens_hsa049660.56911117
66Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55270490
67Dorso-ventral axis formation_Homo sapiens_hsa043200.54108789
68Circadian rhythm_Homo sapiens_hsa047100.52508677
69Taste transduction_Homo sapiens_hsa047420.52257858
70Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51956026
71Tryptophan metabolism_Homo sapiens_hsa003800.50972722
72Antigen processing and presentation_Homo sapiens_hsa046120.49491387
73Cardiac muscle contraction_Homo sapiens_hsa042600.49444065
74Metabolic pathways_Homo sapiens_hsa011000.49014025
75Arginine and proline metabolism_Homo sapiens_hsa003300.48405555
76Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.47311433
77Viral carcinogenesis_Homo sapiens_hsa052030.44319166
78Peroxisome_Homo sapiens_hsa041460.42596636
79Fatty acid metabolism_Homo sapiens_hsa012120.41370458
80Wnt signaling pathway_Homo sapiens_hsa043100.38401813
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37832521
82mTOR signaling pathway_Homo sapiens_hsa041500.33834795
83Linoleic acid metabolism_Homo sapiens_hsa005910.33575690
84Caffeine metabolism_Homo sapiens_hsa002320.32964938
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.32948415
86Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.32733334
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.31951161
88Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.31259823
89Arachidonic acid metabolism_Homo sapiens_hsa005900.30148273
90Basal cell carcinoma_Homo sapiens_hsa052170.30043949
91Herpes simplex infection_Homo sapiens_hsa051680.29243398
92Renin-angiotensin system_Homo sapiens_hsa046140.29207669
93Huntingtons disease_Homo sapiens_hsa050160.29117797
94Hippo signaling pathway_Homo sapiens_hsa043900.26483349
95Galactose metabolism_Homo sapiens_hsa000520.25553994
96Glycerolipid metabolism_Homo sapiens_hsa005610.25104099
97Starch and sucrose metabolism_Homo sapiens_hsa005000.24204216
98Lysine degradation_Homo sapiens_hsa003100.23815266
99Nicotine addiction_Homo sapiens_hsa050330.21634331
100Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.21413934
101FoxO signaling pathway_Homo sapiens_hsa040680.20933694
102HTLV-I infection_Homo sapiens_hsa051660.20594455
103Longevity regulating pathway - mammal_Homo sapiens_hsa042110.17642564
104Sphingolipid metabolism_Homo sapiens_hsa006000.17195980
105alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.17125865
106Systemic lupus erythematosus_Homo sapiens_hsa053220.16018539
107Mineral absorption_Homo sapiens_hsa049780.14883697
108Lysosome_Homo sapiens_hsa041420.13904488
109MicroRNAs in cancer_Homo sapiens_hsa052060.12604617
110beta-Alanine metabolism_Homo sapiens_hsa004100.12400760
111Hedgehog signaling pathway_Homo sapiens_hsa043400.11439081
112Tight junction_Homo sapiens_hsa045300.09569647
113Inositol phosphate metabolism_Homo sapiens_hsa005620.07873524
114Small cell lung cancer_Homo sapiens_hsa052220.07461258
115HIF-1 signaling pathway_Homo sapiens_hsa040660.07405097
116Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.06998455
117Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.05961874
118Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.05559595
119Retinol metabolism_Homo sapiens_hsa008300.05218458
120Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.04161851
121Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.03524462
122Butanoate metabolism_Homo sapiens_hsa006500.03315517
123Thyroid cancer_Homo sapiens_hsa052160.02275108
124NOD-like receptor signaling pathway_Homo sapiens_hsa04621-0.0632898
125Prostate cancer_Homo sapiens_hsa05215-0.0616688
126Legionellosis_Homo sapiens_hsa05134-0.0560704
127Renal cell carcinoma_Homo sapiens_hsa05211-0.0511181
128Fat digestion and absorption_Homo sapiens_hsa04975-0.0504591
129Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280-0.0379936
130AMPK signaling pathway_Homo sapiens_hsa04152-0.0354938
131TGF-beta signaling pathway_Homo sapiens_hsa04350-0.0310586
132Ether lipid metabolism_Homo sapiens_hsa00565-0.0231625
133Prion diseases_Homo sapiens_hsa05020-0.0033103
134Apoptosis_Homo sapiens_hsa04210-0.0010941

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