DPPA2P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)8.82316356
2sequestering of actin monomers (GO:0042989)5.23748500
3chaperone-mediated protein transport (GO:0072321)5.14119065
4metallo-sulfur cluster assembly (GO:0031163)4.99998087
5iron-sulfur cluster assembly (GO:0016226)4.99998087
6negative regulation of alpha-beta T cell differentiation (GO:0046639)4.91791889
7negative T cell selection (GO:0043383)4.78273294
8proteasome assembly (GO:0043248)4.71363199
9establishment of protein localization to mitochondrial membrane (GO:0090151)4.69993262
10negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)4.49726266
11negative regulation of T-helper cell differentiation (GO:0045623)4.49726266
12platelet dense granule organization (GO:0060155)4.45838660
13histone mRNA catabolic process (GO:0071044)4.38925983
14negative thymic T cell selection (GO:0045060)4.04381054
15axoneme assembly (GO:0035082)4.03176526
16response to UV-C (GO:0010225)3.95737189
17cellular ketone body metabolic process (GO:0046950)3.95717123
18negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.92799800
19L-fucose metabolic process (GO:0042354)3.84747840
20L-fucose catabolic process (GO:0042355)3.84747840
21fucose catabolic process (GO:0019317)3.84747840
22serine family amino acid catabolic process (GO:0009071)3.82201135
23base-excision repair, AP site formation (GO:0006285)3.68686772
24tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.68424066
25RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.68424066
26mitochondrial calcium ion transport (GO:0006851)3.58378528
27ketone body metabolic process (GO:1902224)3.52063134
28branched-chain amino acid metabolic process (GO:0009081)3.47375676
29regulation of male gonad development (GO:2000018)3.40348780
30branched-chain amino acid catabolic process (GO:0009083)3.38641215
31negative regulation of glial cell proliferation (GO:0060253)3.33437241
32inner mitochondrial membrane organization (GO:0007007)3.30521513
33protein K11-linked deubiquitination (GO:0035871)3.29287615
34positive T cell selection (GO:0043368)3.20811568
35negative regulation of alpha-beta T cell activation (GO:0046636)3.20543476
36deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.16673782
37protein complex biogenesis (GO:0070271)3.16596851
38epithelial cilium movement (GO:0003351)3.14999258
39replication fork processing (GO:0031297)3.10542563
40purine deoxyribonucleotide metabolic process (GO:0009151)3.10101853
41seminiferous tubule development (GO:0072520)3.08380889
42DNA demethylation (GO:0080111)3.03981011
43DNA dealkylation (GO:0035510)3.03618990
44CD4-positive, alpha-beta T cell activation (GO:0035710)3.03452029
45mitochondrial respiratory chain complex I assembly (GO:0032981)3.02929191
46NADH dehydrogenase complex assembly (GO:0010257)3.02929191
47mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.02929191
48negative regulation of systemic arterial blood pressure (GO:0003085)3.02296892
49purine deoxyribonucleotide catabolic process (GO:0009155)2.99588427
50regulation of glutamate secretion (GO:0014048)2.98482983
51positive regulation of megakaryocyte differentiation (GO:0045654)2.94137687
52lipopolysaccharide biosynthetic process (GO:0009103)2.91265605
53maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.89082249
54centriole replication (GO:0007099)2.88930515
55mitochondrial respiratory chain complex assembly (GO:0033108)2.87950831
56limb bud formation (GO:0060174)2.87630969
57lipopolysaccharide metabolic process (GO:0008653)2.85606129
58regulation of megakaryocyte differentiation (GO:0045652)2.85415305
59mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.85378547
60regulation of glial cell proliferation (GO:0060251)2.84537400
61cytoplasmic mRNA processing body assembly (GO:0033962)2.84286556
62epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.81817420
63valine metabolic process (GO:0006573)2.80498767
64intraciliary transport (GO:0042073)2.78861821
65resolution of meiotic recombination intermediates (GO:0000712)2.78240378
66purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.76738943
67mannosylation (GO:0097502)2.76280465
68adaptation of signaling pathway (GO:0023058)2.76163977
69ribosome biogenesis (GO:0042254)2.74972313
70estrogen biosynthetic process (GO:0006703)2.74544280
71ATP synthesis coupled proton transport (GO:0015986)2.73616732
72energy coupled proton transport, down electrochemical gradient (GO:0015985)2.73616732
73cytochrome complex assembly (GO:0017004)2.73161708
74negative regulation of synaptic transmission, GABAergic (GO:0032229)2.73017407
75mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.71622851
76positive regulation of amino acid transport (GO:0051957)2.71381534
77regulation of regulatory T cell differentiation (GO:0045589)2.69775185
78negative regulation of T cell differentiation (GO:0045581)2.69692825
79chondrocyte proliferation (GO:0035988)2.69056738
80respiratory chain complex IV assembly (GO:0008535)2.68778229
812-deoxyribonucleotide metabolic process (GO:0009394)2.66883350
82male meiosis I (GO:0007141)2.66860200
83adenosine metabolic process (GO:0046085)2.66114120
84nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.64694143
85DNA replication-dependent nucleosome organization (GO:0034723)2.63346204
86DNA replication-dependent nucleosome assembly (GO:0006335)2.63346204
87pseudouridine synthesis (GO:0001522)2.62760858
88endosome to melanosome transport (GO:0035646)2.58025384
89endosome to pigment granule transport (GO:0043485)2.58025384
90artery development (GO:0060840)2.56949403
91nucleobase biosynthetic process (GO:0046112)2.55626796
92negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.55062291
93regulation of rhodopsin mediated signaling pathway (GO:0022400)2.54542142
94neural tube formation (GO:0001841)2.54345087
95negative regulation of amino acid transport (GO:0051956)2.53843533
96rhodopsin mediated signaling pathway (GO:0016056)2.53731595
97type B pancreatic cell proliferation (GO:0044342)2.53256281
98glyoxylate metabolic process (GO:0046487)2.52715841
99deoxyribonucleotide catabolic process (GO:0009264)2.51821078
100regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.50728165

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.53888259
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.30361978
3MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.28474771
4ELF1_17652178_ChIP-ChIP_JURKAT_Human3.02833714
5GABP_17652178_ChIP-ChIP_JURKAT_Human2.86846628
6RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.78721268
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.75721914
8IGF1R_20145208_ChIP-Seq_DFB_Human2.63365648
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.63141541
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.62960259
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.33176578
12EZH2_22144423_ChIP-Seq_EOC_Human2.32805263
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.32108009
14GBX2_23144817_ChIP-Seq_PC3_Human2.15119643
15AR_21572438_ChIP-Seq_LNCaP_Human2.15076653
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.13258895
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.10973496
18CTBP2_25329375_ChIP-Seq_LNCAP_Human1.98722900
19POU3F2_20337985_ChIP-ChIP_501MEL_Human1.94380544
20BCAT_22108803_ChIP-Seq_LS180_Human1.89660679
21CTBP1_25329375_ChIP-Seq_LNCAP_Human1.87423209
22P300_19829295_ChIP-Seq_ESCs_Human1.84690655
23CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.83386742
24PCGF2_27294783_Chip-Seq_ESCs_Mouse1.80760592
25POU5F1_16153702_ChIP-ChIP_HESCs_Human1.75581904
26VDR_23849224_ChIP-Seq_CD4+_Human1.71711755
27NOTCH1_21737748_ChIP-Seq_TLL_Human1.66111205
28FUS_26573619_Chip-Seq_HEK293_Human1.65310761
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.64062114
30VDR_22108803_ChIP-Seq_LS180_Human1.62970926
31MYC_18940864_ChIP-ChIP_HL60_Human1.62125201
32IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.54897455
33SRF_21415370_ChIP-Seq_HL-1_Mouse1.51039076
34AR_20517297_ChIP-Seq_VCAP_Human1.50443888
35AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.49455327
36TAF15_26573619_Chip-Seq_HEK293_Human1.47163845
37EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.41572901
38FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.40204181
39CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.39365443
40JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.37478009
41STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.35858415
42GATA3_26560356_Chip-Seq_TH2_Human1.35809009
43TCF4_22108803_ChIP-Seq_LS180_Human1.32791682
44EZH2_27294783_Chip-Seq_NPCs_Mouse1.32776573
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32283227
46MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.30987439
47ELK1_19687146_ChIP-ChIP_HELA_Human1.30666575
48EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.28839031
49AR_25329375_ChIP-Seq_VCAP_Human1.28495915
50ER_23166858_ChIP-Seq_MCF-7_Human1.28444971
51EWS_26573619_Chip-Seq_HEK293_Human1.28293424
52FOXP3_21729870_ChIP-Seq_TREG_Human1.28001763
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.27680555
54IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.26609366
55ETS1_20019798_ChIP-Seq_JURKAT_Human1.24685788
56SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.24017838
57NANOG_19829295_ChIP-Seq_ESCs_Human1.23397088
58SOX2_19829295_ChIP-Seq_ESCs_Human1.23397088
59SOX2_16153702_ChIP-ChIP_HESCs_Human1.23341787
60PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.22693726
61TP53_22573176_ChIP-Seq_HFKS_Human1.22021749
62CRX_20693478_ChIP-Seq_RETINA_Mouse1.20949573
63FOXA1_25329375_ChIP-Seq_VCAP_Human1.20179391
64FOXA1_27270436_Chip-Seq_PROSTATE_Human1.20179391
65EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.19796068
66AUTS2_25519132_ChIP-Seq_293T-REX_Human1.19189879
67MYC_19829295_ChIP-Seq_ESCs_Human1.16253816
68SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14601149
69PIAS1_25552417_ChIP-Seq_VCAP_Human1.13556804
70TCF4_23295773_ChIP-Seq_U87_Human1.12012154
71RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.11951324
72RUNX2_22187159_ChIP-Seq_PCA_Human1.11705586
73RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.11624107
74SMAD4_21799915_ChIP-Seq_A2780_Human1.11620181
75EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.09355112
76CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.09063453
77CBP_20019798_ChIP-Seq_JUKART_Human1.08041557
78IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.08041557
79E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.07673664
80PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.06770266
81NANOG_20526341_ChIP-Seq_ESCs_Human1.05170023
82OCT4_21477851_ChIP-Seq_ESCs_Mouse1.03213579
83CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01937717
84NCOR_22424771_ChIP-Seq_293T_Human1.00147207
85GATA1_26923725_Chip-Seq_HPCs_Mouse0.99974488
86FOXH1_21741376_ChIP-Seq_EPCs_Human0.99967252
87KDM2B_26808549_Chip-Seq_REH_Human0.99028219
88FOXA1_21572438_ChIP-Seq_LNCaP_Human0.98821214
89SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.98336949
90NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96951034
91YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96690280
92HOXB7_26014856_ChIP-Seq_BT474_Human0.96404025
93E2F1_17053090_ChIP-ChIP_MCF-7_Human0.96028630
94RNF2_27304074_Chip-Seq_NSC_Mouse0.95976309
95GATA3_21878914_ChIP-Seq_MCF-7_Human0.94095210
96CIITA_25753668_ChIP-Seq_RAJI_Human0.93680670
97CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.93622492
98EGR1_23403033_ChIP-Seq_LIVER_Mouse0.93488965
99MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92939657
100SMAD4_21741376_ChIP-Seq_EPCs_Human0.92250635

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting4.66924565
2MP0003123_paternal_imprinting3.98130131
3MP0002138_abnormal_hepatobiliary_system3.97029999
4MP0008875_abnormal_xenobiotic_pharmacok3.27498662
5MP0000372_irregular_coat_pigmentation2.87350037
6MP0002102_abnormal_ear_morphology2.45985122
7MP0008877_abnormal_DNA_methylation2.44901225
8MP0000566_synostosis2.42021932
9MP0005671_abnormal_response_to2.32422152
10MP0010030_abnormal_orbit_morphology2.28749039
11MP0003121_genomic_imprinting2.24304938
12MP0008058_abnormal_DNA_repair2.20352209
13MP0001986_abnormal_taste_sensitivity2.12800271
14MP0001764_abnormal_homeostasis2.10475138
15MP0001346_abnormal_lacrimal_gland2.02805932
16MP0002234_abnormal_pharynx_morphology1.99978943
17MP0005647_abnormal_sex_gland1.84378055
18MP0004145_abnormal_muscle_electrophysio1.82329294
19MP0008872_abnormal_physiological_respon1.72185972
20MP0003195_calcinosis1.71575079
21MP0003878_abnormal_ear_physiology1.70082522
22MP0005377_hearing/vestibular/ear_phenot1.70082522
23MP0003880_abnormal_central_pattern1.69786580
24MP0005075_abnormal_melanosome_morpholog1.67733047
25MP0001529_abnormal_vocalization1.63363702
26MP0005310_abnormal_salivary_gland1.50419426
27MP0002735_abnormal_chemical_nociception1.50263643
28MP0002938_white_spotting1.49796619
29MP0001485_abnormal_pinna_reflex1.47768114
30MP0001968_abnormal_touch/_nociception1.46494115
31MP0003283_abnormal_digestive_organ1.30977377
32MP0005645_abnormal_hypothalamus_physiol1.27257417
33MP0000516_abnormal_urinary_system1.26833820
34MP0005367_renal/urinary_system_phenotyp1.26833820
35MP0003724_increased_susceptibility_to1.25185750
36MP0002837_dystrophic_cardiac_calcinosis1.23355467
37MP0002736_abnormal_nociception_after1.23336696
38MP0005551_abnormal_eye_electrophysiolog1.18970875
39MP0002163_abnormal_gland_morphology1.13889909
40MP0003866_abnormal_defecation1.13608696
41MP0009046_muscle_twitch1.12626039
42MP0002132_abnormal_respiratory_system1.11367347
43MP0003763_abnormal_thymus_physiology1.10964603
44MP0003137_abnormal_impulse_conducting1.10921935
45MP0004147_increased_porphyrin_level1.09626937
46MP0002751_abnormal_autonomic_nervous1.09310429
47MP0002933_joint_inflammation1.08536009
48MP0009764_decreased_sensitivity_to1.07243292
49MP0001119_abnormal_female_reproductive1.04833989
50MP0005084_abnormal_gallbladder_morpholo1.04163416
51MP0001501_abnormal_sleep_pattern1.02638774
52MP0005646_abnormal_pituitary_gland1.01767889
53MP0005248_abnormal_Harderian_gland1.00573486
54MP0003252_abnormal_bile_duct0.99693714
55MP0005253_abnormal_eye_physiology0.99622036
56MP0002282_abnormal_trachea_morphology0.99433390
57MP0003638_abnormal_response/metabolism_0.99179367
58MP0002127_abnormal_cardiovascular_syste0.98283705
59MP0006036_abnormal_mitochondrial_physio0.98185384
60MP0010368_abnormal_lymphatic_system0.96016902
61MP0003718_maternal_effect0.95886867
62MP0003011_delayed_dark_adaptation0.95176266
63MP0005085_abnormal_gallbladder_physiolo0.93478002
64MP0002733_abnormal_thermal_nociception0.93388603
65MP0009765_abnormal_xenobiotic_induced0.92154795
66MP0004742_abnormal_vestibular_system0.90734716
67MP0005379_endocrine/exocrine_gland_phen0.90146741
68MP0003567_abnormal_fetal_cardiomyocyte0.90134892
69MP0009785_altered_susceptibility_to0.89582576
70MP0002139_abnormal_hepatobiliary_system0.89443436
71MP0003122_maternal_imprinting0.89114645
72MP0005000_abnormal_immune_tolerance0.88766688
73MP0001348_abnormal_lacrimal_gland0.88747545
74MP0002932_abnormal_joint_morphology0.88340835
75MP0001486_abnormal_startle_reflex0.86674651
76MP0009053_abnormal_anal_canal0.86533308
77MP0001800_abnormal_humoral_immune0.84010955
78MP0001879_abnormal_lymphatic_vessel0.82936334
79MP0002909_abnormal_adrenal_gland0.82789908
80MP0003186_abnormal_redox_activity0.82256277
81MP0001929_abnormal_gametogenesis0.81756482
82MP0002928_abnormal_bile_duct0.81082676
83MP0002210_abnormal_sex_determination0.80560643
84MP0000467_abnormal_esophagus_morphology0.79562766
85MP0006292_abnormal_olfactory_placode0.78793581
86MP0002693_abnormal_pancreas_physiology0.75898804
87MP0000383_abnormal_hair_follicle0.75267281
88MP0003938_abnormal_ear_development0.74863634
89MP0001970_abnormal_pain_threshold0.73577556
90MP0005167_abnormal_blood-brain_barrier0.73179341
91MP0003698_abnormal_male_reproductive0.72894008
92MP0001293_anophthalmia0.71230497
93MP0002638_abnormal_pupillary_reflex0.69615038
94MP0002396_abnormal_hematopoietic_system0.69530454
95MP0002420_abnormal_adaptive_immunity0.69285449
96MP0006072_abnormal_retinal_apoptosis0.67229412
97MP0000653_abnormal_sex_gland0.67183477
98MP0000639_abnormal_adrenal_gland0.67119668
99MP0001819_abnormal_immune_cell0.66756455
100MP0003937_abnormal_limbs/digits/tail_de0.65318566

Predicted human phenotypes

RankGene SetZ-score
1Cerebellar dysplasia (HP:0007033)4.60624992
2Acute necrotizing encephalopathy (HP:0006965)4.29077545
3Severe combined immunodeficiency (HP:0004430)4.07142832
4Type II lissencephaly (HP:0007260)3.86273594
5Mitochondrial inheritance (HP:0001427)3.81181662
6Abnormal mitochondria in muscle tissue (HP:0008316)3.62859560
7Retinal dysplasia (HP:0007973)3.58328029
8Acute encephalopathy (HP:0006846)3.47905737
9Progressive macrocephaly (HP:0004481)3.46071228
10Aplastic anemia (HP:0001915)3.37735189
11Increased CSF lactate (HP:0002490)3.34353808
12Pancreatic cysts (HP:0001737)3.23703105
13High anterior hairline (HP:0009890)3.13619754
14Congenital stationary night blindness (HP:0007642)3.08647932
15Prostate neoplasm (HP:0100787)3.04187104
16True hermaphroditism (HP:0010459)3.02269713
17Hyperglycinuria (HP:0003108)2.99579119
18Combined immunodeficiency (HP:0005387)2.99422718
19Absent rod-and cone-mediated responses on ERG (HP:0007688)2.95912801
20Occipital encephalocele (HP:0002085)2.95180133
21Chromsome breakage (HP:0040012)2.94583486
22Short tibia (HP:0005736)2.91987138
23Aplasia/Hypoplasia of the uvula (HP:0010293)2.87101353
24Aplasia/Hypoplasia of the tibia (HP:0005772)2.83036916
25Cerebral edema (HP:0002181)2.75359538
26Stenosis of the external auditory canal (HP:0000402)2.69387714
27Hepatocellular necrosis (HP:0001404)2.69074984
28Hypoproteinemia (HP:0003075)2.60015234
29Decreased central vision (HP:0007663)2.51669609
30Increased hepatocellular lipid droplets (HP:0006565)2.50477313
31Flat capital femoral epiphysis (HP:0003370)2.49363767
32Restlessness (HP:0000711)2.46169828
33Abnormality of the labia minora (HP:0012880)2.41230770
34Chromosomal breakage induced by crosslinking agents (HP:0003221)2.39991915
35Hepatic necrosis (HP:0002605)2.37127408
36Abnormality of glycine metabolism (HP:0010895)2.36540189
37Abnormality of serine family amino acid metabolism (HP:0010894)2.36540189
38Optic disc pallor (HP:0000543)2.35047647
39Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.33086958
40Renal cortical cysts (HP:0000803)2.26411305
41Anencephaly (HP:0002323)2.22533803
42Pancreatic fibrosis (HP:0100732)2.21478809
43Tinnitus (HP:0000360)2.20476079
44Abnormality of the ileum (HP:0001549)2.17033315
45Retinal atrophy (HP:0001105)2.16802923
46Oral leukoplakia (HP:0002745)2.15922244
47Neonatal respiratory distress (HP:0002643)2.15772406
48Agammaglobulinemia (HP:0004432)2.15278029
49Hypothermia (HP:0002045)2.13583602
50Abnormality of T cell physiology (HP:0011840)2.13415215
51Type 2 muscle fiber atrophy (HP:0003554)2.13172190
52Intestinal atresia (HP:0011100)2.12856954
53Progressive cerebellar ataxia (HP:0002073)2.11342803
54Abnormality of T cells (HP:0002843)2.07708760
55Lipid accumulation in hepatocytes (HP:0006561)2.07451530
56Abnormal albumin level (HP:0012116)2.06281796
57Hypoalbuminemia (HP:0003073)2.06281796
58Hyperphosphaturia (HP:0003109)2.05842642
59Hypoplastic pelvis (HP:0008839)2.05055737
60Dyskinesia (HP:0100660)2.03940663
61Abnormality of the renal cortex (HP:0011035)1.99928566
62Exertional dyspnea (HP:0002875)1.98831656
63Rib fusion (HP:0000902)1.97094214
64Thyroid-stimulating hormone excess (HP:0002925)1.94129503
65Meckel diverticulum (HP:0002245)1.93384833
66Type I transferrin isoform profile (HP:0003642)1.92448696
67Irregular epiphyses (HP:0010582)1.92209239
68Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.91659502
69Absent epiphyses (HP:0010577)1.91659502
70Respiratory failure (HP:0002878)1.91140332
71Elevated erythrocyte sedimentation rate (HP:0003565)1.90262283
72Fibular hypoplasia (HP:0003038)1.89063799
73Diaphragmatic weakness (HP:0009113)1.88913124
74Abnormality of midbrain morphology (HP:0002418)1.88454111
75Molar tooth sign on MRI (HP:0002419)1.88454111
76Mesangial abnormality (HP:0001966)1.88174232
77Cystic liver disease (HP:0006706)1.87740467
78Volvulus (HP:0002580)1.84364656
79Renal hypoplasia (HP:0000089)1.83857417
80Attenuation of retinal blood vessels (HP:0007843)1.82434907
81Sclerocornea (HP:0000647)1.80208444
82Leukocytosis (HP:0001974)1.80042843
83Triphalangeal thumb (HP:0001199)1.79810347
84Amyotrophic lateral sclerosis (HP:0007354)1.79304685
85Hyperglycinemia (HP:0002154)1.79143938
86Abnormal rod and cone electroretinograms (HP:0008323)1.78277704
87Exotropia (HP:0000577)1.78241120
88Leukodystrophy (HP:0002415)1.77587706
89Decreased lacrimation (HP:0000633)1.77553155
90Lactic acidosis (HP:0003128)1.77205936
91Preaxial hand polydactyly (HP:0001177)1.76640626
92Abnormal number of erythroid precursors (HP:0012131)1.76399681
93Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.75912710
94Progressive microcephaly (HP:0000253)1.75430715
95Weak cry (HP:0001612)1.75233172
96Choroideremia (HP:0001139)1.73404430
97Thyroiditis (HP:0100646)1.72629139
98Lethargy (HP:0001254)1.72272023
99Absent/shortened dynein arms (HP:0200106)1.71768503
100Dynein arm defect of respiratory motile cilia (HP:0012255)1.71768503

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K29.40968307
2KDR4.59783090
3NUAK13.53725155
4TESK23.45012701
5PLK42.88535334
6CDK192.64133338
7VRK22.43757764
8SCYL22.28163987
9MUSK2.24607271
10BCKDK2.15076558
11ADRBK22.12551652
12IRAK12.10642388
13ZAK2.09648091
14LIMK12.01700343
15TXK2.00612516
16TGFBR21.83107978
17TAOK31.69483206
18OXSR11.68095944
19TESK11.66129229
20IRAK21.64262447
21MAPK131.52456258
22RIPK41.41242522
23EPHA41.24412911
24GRK71.16111539
25VRK11.14010725
26YES11.11077875
27GRK61.07468216
28FRK1.05546869
29DYRK20.98644123
30TIE10.93321180
31MST40.93249652
32IRAK40.91757537
33TAF10.90351356
34TLK10.89903076
35TEC0.88064156
36WNK30.83394223
37INSRR0.82442002
38GRK10.82338068
39PRKCQ0.77651905
40ERBB30.72130599
41SRPK10.70381952
42EIF2AK30.69540653
43MKNK10.66701083
44LRRK20.65650884
45TNIK0.63981472
46KIT0.61863499
47MAPKAPK50.61807988
48EIF2AK20.61511211
49ITK0.58148648
50BMX0.56832751
51CAMKK20.50669594
52ADRBK10.50160185
53MAP3K40.49686003
54PIM20.47297378
55BMPR1B0.45783631
56ROCK10.42198411
57EPHA30.41398718
58STK390.39771176
59NEK10.39342568
60EPHB10.37551220
61IKBKE0.35628297
62PLK20.34544380
63CSNK1G20.34053830
64TGFBR10.34016062
65LYN0.31022513
66SYK0.30829771
67MAPK150.30478270
68SIK30.27871786
69STK38L0.26485194
70OBSCN0.26170489
71ROCK20.26125413
72ALK0.24653437
73CSNK1G30.24646403
74ABL10.23827832
75INSR0.23655424
76GRK50.23642563
77BCR0.23615679
78RAF10.23597327
79SIK20.22707684
80CAMK1D0.22602828
81BRSK10.21993580
82PBK0.21711154
83DMPK0.21616656
84TAOK20.21603421
85RPS6KA50.21091554
86TRIM280.21079647
87PRKCE0.20982109
88CDK30.20359215
89LCK0.19765386
90CDC70.18647891
91MKNK20.18508319
92MARK30.15817232
93PDK20.15709131
94HCK0.15512586
95CSNK1G10.15107053
96ATR0.15057280
97PDK10.14634055
98CSNK1D0.14598121
99PLK10.13212351
100ATM0.12488093

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.08167036
2Sulfur metabolism_Homo sapiens_hsa009203.94394474
3Caffeine metabolism_Homo sapiens_hsa002323.78867180
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.97983088
5Oxidative phosphorylation_Homo sapiens_hsa001902.72853849
6Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.55459661
7Parkinsons disease_Homo sapiens_hsa050122.36382135
8SNARE interactions in vesicular transport_Homo sapiens_hsa041302.28324032
9Phototransduction_Homo sapiens_hsa047442.19244266
10Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.08596743
11Homologous recombination_Homo sapiens_hsa034402.07773475
12Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.06456746
13Proteasome_Homo sapiens_hsa030502.02318044
14Fatty acid biosynthesis_Homo sapiens_hsa000611.95330633
15Sulfur relay system_Homo sapiens_hsa041221.93239010
16Butanoate metabolism_Homo sapiens_hsa006501.84063336
17Huntingtons disease_Homo sapiens_hsa050161.78612807
18Cyanoamino acid metabolism_Homo sapiens_hsa004601.74105240
19Phenylalanine metabolism_Homo sapiens_hsa003601.73388932
20Ribosome_Homo sapiens_hsa030101.68431563
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.62839349
22Propanoate metabolism_Homo sapiens_hsa006401.53344646
23Linoleic acid metabolism_Homo sapiens_hsa005911.49817993
24Alzheimers disease_Homo sapiens_hsa050101.46993653
25RNA degradation_Homo sapiens_hsa030181.45154297
26Basal transcription factors_Homo sapiens_hsa030221.44700753
27Protein export_Homo sapiens_hsa030601.43607809
28Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.42389945
29Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.41913849
30RNA polymerase_Homo sapiens_hsa030201.41024193
31Tyrosine metabolism_Homo sapiens_hsa003501.38782127
32Malaria_Homo sapiens_hsa051441.35682803
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.34081027
34Cardiac muscle contraction_Homo sapiens_hsa042601.31052118
35Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.30411791
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.18911183
37Olfactory transduction_Homo sapiens_hsa047401.15395341
38Tryptophan metabolism_Homo sapiens_hsa003801.13753924
39Nitrogen metabolism_Homo sapiens_hsa009101.12821194
40Steroid hormone biosynthesis_Homo sapiens_hsa001401.12184359
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.08995269
42Fanconi anemia pathway_Homo sapiens_hsa034601.06797808
43beta-Alanine metabolism_Homo sapiens_hsa004101.06031947
44Base excision repair_Homo sapiens_hsa034100.98190712
45Pyrimidine metabolism_Homo sapiens_hsa002400.97749890
46Chemical carcinogenesis_Homo sapiens_hsa052040.97537688
47Purine metabolism_Homo sapiens_hsa002300.94520726
48alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.93674374
49Glutathione metabolism_Homo sapiens_hsa004800.93384310
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.91889660
51Non-homologous end-joining_Homo sapiens_hsa034500.90760999
52Collecting duct acid secretion_Homo sapiens_hsa049660.88970541
53Taste transduction_Homo sapiens_hsa047420.88370872
54Maturity onset diabetes of the young_Homo sapiens_hsa049500.87849311
55Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.84204921
56One carbon pool by folate_Homo sapiens_hsa006700.83488883
57Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.83145671
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.80937930
59Drug metabolism - other enzymes_Homo sapiens_hsa009830.78879648
60Retinol metabolism_Homo sapiens_hsa008300.77226209
61T cell receptor signaling pathway_Homo sapiens_hsa046600.76597494
62Histidine metabolism_Homo sapiens_hsa003400.75941255
63ABC transporters_Homo sapiens_hsa020100.74549743
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.67405126
65Fat digestion and absorption_Homo sapiens_hsa049750.66928023
66Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.65648987
67Cysteine and methionine metabolism_Homo sapiens_hsa002700.61449897
68RNA transport_Homo sapiens_hsa030130.61004027
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59616947
70Metabolic pathways_Homo sapiens_hsa011000.57703858
71Arachidonic acid metabolism_Homo sapiens_hsa005900.57655232
72Peroxisome_Homo sapiens_hsa041460.55585625
73Graft-versus-host disease_Homo sapiens_hsa053320.52481450
74Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.50475433
75mRNA surveillance pathway_Homo sapiens_hsa030150.50220157
76Fatty acid degradation_Homo sapiens_hsa000710.48372706
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47863390
78Systemic lupus erythematosus_Homo sapiens_hsa053220.44771471
79Axon guidance_Homo sapiens_hsa043600.43283766
80Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.43001449
81Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.42569766
82Hematopoietic cell lineage_Homo sapiens_hsa046400.40381632
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40280728
84Antigen processing and presentation_Homo sapiens_hsa046120.39242586
85Salivary secretion_Homo sapiens_hsa049700.37797521
86Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.36995001
87Ether lipid metabolism_Homo sapiens_hsa005650.35492913
88Regulation of autophagy_Homo sapiens_hsa041400.35003712
892-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.33808207
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32366049
91Fatty acid metabolism_Homo sapiens_hsa012120.31877720
92Allograft rejection_Homo sapiens_hsa053300.30289867
93Circadian rhythm_Homo sapiens_hsa047100.30062131
94Pyruvate metabolism_Homo sapiens_hsa006200.28713691
95Morphine addiction_Homo sapiens_hsa050320.27639035
96Alcoholism_Homo sapiens_hsa050340.27000392
97Glycerolipid metabolism_Homo sapiens_hsa005610.25934070
98Thyroid hormone synthesis_Homo sapiens_hsa049180.20408244
99Autoimmune thyroid disease_Homo sapiens_hsa053200.20028759
100Renin-angiotensin system_Homo sapiens_hsa046140.19316224

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