DPPA3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that in mice may function as a maternal factor during the preimplantation stage of development. In mice, this gene may play a role in transcriptional repression, cell division, and maintenance of cell pluripotentiality. In humans, related intronless loci are located on chromosomes 14 and X. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of retinoic acid receptor signaling pathway (GO:0048387)9.32505478
2regulation of meiosis I (GO:0060631)8.27626438
3regulation of retinoic acid receptor signaling pathway (GO:0048385)8.08580500
4regulation of female gonad development (GO:2000194)7.92346691
5piRNA metabolic process (GO:0034587)7.85018379
6meiotic cell cycle (GO:0051321)7.46972942
7* regulation of DNA methylation (GO:0044030)6.78920470
8mitotic metaphase plate congression (GO:0007080)6.53112134
9retinal cone cell development (GO:0046549)6.06372850
10DNA methylation involved in gamete generation (GO:0043046)5.98379123
11purine nucleobase biosynthetic process (GO:0009113)5.90256938
12female gamete generation (GO:0007292)5.82243153
13positive regulation of histone H3-K4 methylation (GO:0051571)5.64534178
14ribosome assembly (GO:0042255)5.62461415
15positive regulation of mitotic metaphase/anaphase transition (GO:0045842)5.46701319
16positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)5.46701319
17positive regulation of mitotic sister chromatid separation (GO:1901970)5.46701319
18regulation of histone H3-K9 methylation (GO:0051570)5.41043743
19regulation of acrosome reaction (GO:0060046)5.37931404
20rRNA modification (GO:0000154)5.23726402
21nucleobase biosynthetic process (GO:0046112)5.21761061
22glycine transport (GO:0015816)5.13828564
23regulation of spindle organization (GO:0090224)5.09236766
24DNA replication checkpoint (GO:0000076)5.09116355
25male meiosis I (GO:0007141)5.08053697
26oocyte development (GO:0048599)5.07494073
27metaphase plate congression (GO:0051310)5.04971708
28regulation of cell maturation (GO:1903429)4.94001358
29synapsis (GO:0007129)4.93450549
30regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.91849528
31gene silencing by RNA (GO:0031047)4.86762059
32ribosome biogenesis (GO:0042254)4.83516232
33primitive streak formation (GO:0090009)4.83289048
34protein localization to kinetochore (GO:0034501)4.80868769
35regulation of steroid hormone secretion (GO:2000831)4.79572152
36positive regulation of gastrulation (GO:2000543)4.78101648
37multicellular organism reproduction (GO:0032504)4.70494350
38centriole replication (GO:0007099)4.62492605
39negative regulation of histone methylation (GO:0031061)4.42706033
40attachment of spindle microtubules to kinetochore (GO:0008608)4.40639552
41termination of RNA polymerase III transcription (GO:0006386)4.40458506
42transcription elongation from RNA polymerase III promoter (GO:0006385)4.40458506
43male meiosis (GO:0007140)4.37746039
44folic acid metabolic process (GO:0046655)4.35451415
45negative regulation of reproductive process (GO:2000242)4.34562633
46positive regulation of chromosome segregation (GO:0051984)4.33236203
47intestinal epithelial cell development (GO:0060576)4.29808970
48regulation of mitotic spindle organization (GO:0060236)4.25749557
49proteasome assembly (GO:0043248)4.20949583
50rRNA methylation (GO:0031167)4.11557106
517-methylguanosine mRNA capping (GO:0006370)4.10984742
52chromosome organization involved in meiosis (GO:0070192)4.10517291
53protein localization to chromosome, centromeric region (GO:0071459)4.09447934
54establishment of chromosome localization (GO:0051303)4.08629211
55regulation of meiosis (GO:0040020)4.08521648
56maturation of 5.8S rRNA (GO:0000460)4.06995649
57pyrimidine-containing compound transmembrane transport (GO:0072531)4.05312103
58transcription from RNA polymerase I promoter (GO:0006360)4.05116314
59regulation of translation in response to stress (GO:0043555)3.99709705
60RNA capping (GO:0036260)3.99386965
617-methylguanosine RNA capping (GO:0009452)3.99386965
62folic acid transport (GO:0015884)3.98649720
63spindle checkpoint (GO:0031577)3.96161220
64transcription elongation from RNA polymerase I promoter (GO:0006362)3.94274919
65meiotic nuclear division (GO:0007126)3.93857864
66termination of RNA polymerase I transcription (GO:0006363)3.93307221
67anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.89559932
68regulation of exit from mitosis (GO:0007096)3.88145230
69regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.87448413
70nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.84391695
71vitamin transmembrane transport (GO:0035461)3.82844370
72CENP-A containing nucleosome assembly (GO:0034080)3.78030642
73meiotic cell cycle process (GO:1903046)3.77623239
74somite rostral/caudal axis specification (GO:0032525)3.74951644
75mitotic sister chromatid segregation (GO:0000070)3.71616178
76labyrinthine layer development (GO:0060711)3.71180989
77oogenesis (GO:0048477)3.70247474
78protein K6-linked ubiquitination (GO:0085020)3.67771297
79synaptonemal complex organization (GO:0070193)3.67457129
80regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.64827448
81lung-associated mesenchyme development (GO:0060484)3.64169543
82regulation of chromosome segregation (GO:0051983)3.63500595
83mitotic spindle checkpoint (GO:0071174)3.61589698
84positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)3.61324210
85mitotic nuclear envelope disassembly (GO:0007077)3.60070122
86positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.56918043
87ribonucleoprotein complex biogenesis (GO:0022613)3.56799700
88blastocyst development (GO:0001824)3.56769011
89meiosis I (GO:0007127)3.55829664
90transcription initiation from RNA polymerase I promoter (GO:0006361)3.54565908
91histone exchange (GO:0043486)3.53019024
92chromatin remodeling at centromere (GO:0031055)3.52946710
93regulation of double-strand break repair via homologous recombination (GO:0010569)3.52364859
94L-amino acid import (GO:0043092)3.51223902
95kinetochore assembly (GO:0051382)3.49956852
96DNA replication-independent nucleosome assembly (GO:0006336)3.49502544
97DNA replication-independent nucleosome organization (GO:0034724)3.49502544
98regulation of nuclear cell cycle DNA replication (GO:0033262)3.48618728
99L-methionine salvage (GO:0071267)3.44401939
100L-methionine biosynthetic process (GO:0071265)3.44401939
101amino acid salvage (GO:0043102)3.44401939
102regulation of mitotic metaphase/anaphase transition (GO:0030071)3.44326123
103formation of translation preinitiation complex (GO:0001731)3.44041767
104negative regulation of chromosome segregation (GO:0051985)3.43455580
105positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.43426701
106negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.42387482
107negative regulation of sister chromatid segregation (GO:0033046)3.42387482
108negative regulation of mitotic sister chromatid separation (GO:2000816)3.42387482
109negative regulation of mitotic sister chromatid segregation (GO:0033048)3.42387482
110regulation of meiotic cell cycle (GO:0051445)3.41811662
111spindle assembly checkpoint (GO:0071173)3.41367287
112mitotic spindle assembly checkpoint (GO:0007094)3.41226122
113regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.40695317
114DNA alkylation (GO:0006305)3.40314036
115DNA methylation (GO:0006306)3.40314036
116transcription elongation from RNA polymerase II promoter (GO:0006368)3.40099205
117rRNA processing (GO:0006364)3.39446384
118positive regulation of histone methylation (GO:0031062)3.39212966
119negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.37745811
120regulation of spindle checkpoint (GO:0090231)3.37535613
121membrane disassembly (GO:0030397)3.34142791
122nuclear envelope disassembly (GO:0051081)3.34142791
123negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.33648493
124positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.32535140
125DNA-templated transcription, elongation (GO:0006354)3.30965862
126protein localization to chromosome (GO:0034502)3.30151743
127rRNA metabolic process (GO:0016072)3.29657416
128translesion synthesis (GO:0019985)3.29617169
129regulation of histone H3-K4 methylation (GO:0051569)3.26744997
130histone H2A monoubiquitination (GO:0035518)3.24759295
131synaptonemal complex assembly (GO:0007130)3.22090368
132positive regulation of uterine smooth muscle contraction (GO:0070474)3.21490185
133relaxation of smooth muscle (GO:0044557)3.20506246
134DNA deamination (GO:0045006)3.20276068
135regulation of telomere maintenance via telomerase (GO:0032210)3.20233030
136neuron fate determination (GO:0048664)3.19303165
137positive regulation of viral transcription (GO:0050434)3.18666376
138regulation of mitotic sister chromatid separation (GO:0010965)3.17830035
139regulation of mitotic sister chromatid segregation (GO:0033047)3.17830035
140regulation of sister chromatid segregation (GO:0033045)3.17830035
141DNA damage induced protein phosphorylation (GO:0006975)3.16540194
142N-terminal protein amino acid acetylation (GO:0006474)3.16117340
143centriole assembly (GO:0098534)3.15971481
144oocyte maturation (GO:0001556)3.15536285
145maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.14217565
146regulation of histone methylation (GO:0031060)3.13269817
147microtubule depolymerization (GO:0007019)3.12403268
148gene silencing (GO:0016458)3.12390047
149regulation of G0 to G1 transition (GO:0070316)3.12386543
150spliceosomal snRNP assembly (GO:0000387)3.12238303
151negative regulation of execution phase of apoptosis (GO:1900118)3.12038375
152DNA replication-dependent nucleosome organization (GO:0034723)3.11832784
153DNA replication-dependent nucleosome assembly (GO:0006335)3.11832784
154positive regulation of ligase activity (GO:0051351)3.09885796
155protein kinase C signaling (GO:0070528)3.09797369
156negative regulation of cAMP-mediated signaling (GO:0043951)3.09621590
157mitotic chromosome condensation (GO:0007076)3.09572349
158regulation of steroid hormone biosynthetic process (GO:0090030)3.09489708
159chromosome segregation (GO:0007059)3.09051382
160kinetochore organization (GO:0051383)3.07649664
161DNA replication initiation (GO:0006270)3.06211371
162reproduction (GO:0000003)3.02572417
163regulation of chromatin silencing (GO:0031935)3.01248262
164negative regulation of hormone biosynthetic process (GO:0032353)2.99532759
165fertilization (GO:0009566)2.97120338
166positive regulation of reproductive process (GO:2000243)2.91521577
167negative regulation of hormone metabolic process (GO:0032351)2.86449650
168phosphorelay signal transduction system (GO:0000160)2.83444133
169phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.82662360
170positive regulation of humoral immune response (GO:0002922)2.81832733
171chromatin assembly or disassembly (GO:0006333)2.81646200
172regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.80281122

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.83223220
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.56038742
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.68044701
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.67424999
5FOXM1_23109430_ChIP-Seq_U2OS_Human4.36404913
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.93853583
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.55800804
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.55346606
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.52216065
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.49403454
11GABP_17652178_ChIP-ChIP_JURKAT_Human3.38913943
12E2F4_17652178_ChIP-ChIP_JURKAT_Human3.34549743
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.30253389
14EST1_17652178_ChIP-ChIP_JURKAT_Human3.26673322
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.24704492
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.22008577
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.17730278
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.05777648
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.91664253
20MYC_19079543_ChIP-ChIP_MESCs_Mouse2.87779181
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.72165324
22AR_21909140_ChIP-Seq_LNCAP_Human2.67080416
23MYC_18358816_ChIP-ChIP_MESCs_Mouse2.63018109
24MYC_19030024_ChIP-ChIP_MESCs_Mouse2.61305375
25EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.44241215
26VDR_23849224_ChIP-Seq_CD4+_Human2.42406856
27RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.28575210
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.24689640
29* NANOG_18555785_ChIP-Seq_MESCs_Mouse2.19857784
30CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.17432409
31NELFA_20434984_ChIP-Seq_ESCs_Mouse2.11501373
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.10236185
33PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.08898939
34HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.06321051
35POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.02774759
36EZH2_22144423_ChIP-Seq_EOC_Human10.2875674
37XRN2_22483619_ChIP-Seq_HELA_Human1.99981294
38GABP_19822575_ChIP-Seq_HepG2_Human1.99374287
39KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.96835441
40YY1_21170310_ChIP-Seq_MESCs_Mouse1.91799170
41MYCN_18555785_ChIP-Seq_MESCs_Mouse1.91773376
42E2F1_18555785_ChIP-Seq_MESCs_Mouse1.88860378
43IRF1_19129219_ChIP-ChIP_H3396_Human1.88123318
44MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.84509813
45FOXP3_21729870_ChIP-Seq_TREG_Human1.80015595
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78849386
47KAP1_22055183_ChIP-Seq_ESCs_Mouse1.76746115
48DCP1A_22483619_ChIP-Seq_HELA_Human1.74981388
49MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.71562680
50KDM5A_27292631_Chip-Seq_BREAST_Human1.66154892
51SALL1_21062744_ChIP-ChIP_HESCs_Human1.61329303
52HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.60550213
53TP63_19390658_ChIP-ChIP_HaCaT_Human1.59785116
54YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52053925
55THAP11_20581084_ChIP-Seq_MESCs_Mouse1.51236684
56E2F1_21310950_ChIP-Seq_MCF-7_Human1.49615547
57TTF2_22483619_ChIP-Seq_HELA_Human1.49217992
58* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.46703820
59FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.42071777
60SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.40565064
61* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.38631880
62KLF4_18555785_ChIP-Seq_MESCs_Mouse1.38406618
63SRF_21415370_ChIP-Seq_HL-1_Mouse1.37707126
64BP1_19119308_ChIP-ChIP_Hs578T_Human1.35390013
65PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.35332406
66GBX2_23144817_ChIP-Seq_PC3_Human1.35185464
67ELK1_22589737_ChIP-Seq_MCF10A_Human1.34427684
68ELK1_19687146_ChIP-ChIP_HELA_Human1.33995943
69STAT3_1855785_ChIP-Seq_MESCs_Mouse1.31412002
70* NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.30915753
71UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.30343887
72ZNF274_21170338_ChIP-Seq_K562_Hela1.28207431
73ZNF263_19887448_ChIP-Seq_K562_Human1.25519978
74HTT_18923047_ChIP-ChIP_STHdh_Human1.24773814
75PADI4_21655091_ChIP-ChIP_MCF-7_Human1.24415398
76ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.23052355
77IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.21473276
78CBP_20019798_ChIP-Seq_JUKART_Human1.21473276
79* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.20134715
80ESR1_15608294_ChIP-ChIP_MCF-7_Human1.19548265
81NANOG_21062744_ChIP-ChIP_HESCs_Human1.16659895
82* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.16007008
83LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15686149
84CIITA_25753668_ChIP-Seq_RAJI_Human1.14100481
85TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13551154
86KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.10952606
87ZFX_18555785_ChIP-Seq_MESCs_Mouse1.09225352
88NOTCH1_21737748_ChIP-Seq_TLL_Human1.08858477
89ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.07954122
90CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.06907692
91* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.06818529
92PRDM14_20953172_ChIP-Seq_ESCs_Human1.05994530
93TCF3_18692474_ChIP-Seq_MEFs_Mouse1.04027669
94BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.02620276
95CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.00452197
96HOXB4_20404135_ChIP-ChIP_EML_Mouse1.00250787
97SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.99579961
98DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.99371980
99SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.99220603
100STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.98643299
101TCF4_23295773_ChIP-Seq_U87_Human0.97330774
102CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.97237129
103* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.96926397
104E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.96783555
105EWS_26573619_Chip-Seq_HEK293_Human0.95595237
106TP53_22573176_ChIP-Seq_HFKS_Human0.95123953
107EP300_21415370_ChIP-Seq_HL-1_Mouse0.93341831
108* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.93140197
109SALL4_22934838_ChIP-ChIP_CD34+_Human0.91300568
110* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.90554640
111OCT4_18692474_ChIP-Seq_MEFs_Mouse0.90188650
112* NANOG_20526341_ChIP-Seq_ESCs_Human0.89849997
113GF1_26923725_Chip-Seq_HPCs_Mouse0.89151903
114* KAP1_27257070_Chip-Seq_ESCs_Mouse0.88258459
115EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.88084861
116FOXH1_21741376_ChIP-Seq_EPCs_Human0.88060891
117* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.87958287
118FOXM1_26456572_ChIP-Seq_MCF-7_Human0.87589633
119TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.87265491
120CBP_21632823_ChIP-Seq_H3396_Human0.85676920
121TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.85195507
122CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.82262821
123* TCF3_18692474_ChIP-Seq_MESCs_Mouse0.81591373
124SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.81581171
125AR_25329375_ChIP-Seq_VCAP_Human0.81177860
126POU5F1_16153702_ChIP-ChIP_HESCs_Human0.79832449
127* NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.79783080
128* NANOG_18692474_ChIP-Seq_MESCs_Mouse0.78238407
129TAL1_26923725_Chip-Seq_HPCs_Mouse0.78162851
130GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.77946786
131GATA1_26923725_Chip-Seq_HPCs_Mouse0.77926531
132KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.77423405
133EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.76543134
134SMAD4_21741376_ChIP-Seq_EPCs_Human0.76264379
135CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.76221217
136* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.76081146
137LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.75937832
138PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.75360570
139* KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.75149200
140* KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.75149200
141* KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.75149200
142* SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.74786001
143MYC_18940864_ChIP-ChIP_HL60_Human0.74752105
144RUNX2_22187159_ChIP-Seq_PCA_Human0.74353859
145P300_19829295_ChIP-Seq_ESCs_Human0.73615847
146SMAD4_21799915_ChIP-Seq_A2780_Human0.70292516
147CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.70150206
148PKCTHETA_26484144_Chip-Seq_BREAST_Human0.68275777
149STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.67553063
150AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.67100535
151VDR_22108803_ChIP-Seq_LS180_Human0.66661465
152GATA3_26560356_Chip-Seq_TH1_Human0.65942893
153SOX2_19829295_ChIP-Seq_ESCs_Human0.63342176
154NANOG_19829295_ChIP-Seq_ESCs_Human0.63342176
155RNF2_27304074_Chip-Seq_NSC_Mouse0.61736085
156AR_20517297_ChIP-Seq_VCAP_Human0.61106133
157AHR_22903824_ChIP-Seq_MCF-7_Human0.60284678

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.86977744
2MP0003111_abnormal_nucleus_morphology5.06582334
3MP0004957_abnormal_blastocyst_morpholog4.65440546
4MP0008789_abnormal_olfactory_epithelium4.52067944
5MP0005394_taste/olfaction_phenotype4.00896467
6MP0005499_abnormal_olfactory_system4.00896467
7MP0010094_abnormal_chromosome_stability3.98758857
8MP0003077_abnormal_cell_cycle3.95466845
9* MP0003718_maternal_effect3.93580886
10MP0008057_abnormal_DNA_replication3.28638824
11MP0008260_abnormal_autophagy3.23855819
12MP0002139_abnormal_hepatobiliary_system2.98484644
13MP0008058_abnormal_DNA_repair2.88774960
14MP0003123_paternal_imprinting2.78291048
15MP0010234_abnormal_vibrissa_follicle2.75392916
16MP0010030_abnormal_orbit_morphology2.73745100
17MP0002138_abnormal_hepatobiliary_system2.68863703
18MP0008932_abnormal_embryonic_tissue2.62619819
19MP0003786_premature_aging2.55252803
20MP0008007_abnormal_cellular_replicative2.47850263
21MP0008877_abnormal_DNA_methylation2.46240627
22MP0001730_embryonic_growth_arrest2.37810009
23MP0005360_urolithiasis2.32753305
24MP0001986_abnormal_taste_sensitivity2.23110165
25MP0006292_abnormal_olfactory_placode2.21707449
26MP0002234_abnormal_pharynx_morphology2.18109452
27MP0003315_abnormal_perineum_morphology2.15524036
28MP0005451_abnormal_body_composition2.13503676
29MP0000350_abnormal_cell_proliferation2.02912533
30MP0005380_embryogenesis_phenotype2.00010749
31MP0001672_abnormal_embryogenesis/_devel2.00010749
32MP0003950_abnormal_plasma_membrane1.94562444
33MP0005410_abnormal_fertilization1.94169741
34MP0009840_abnormal_foam_cell1.75776411
35MP0003183_abnormal_peptide_metabolism1.73222807
36MP0002396_abnormal_hematopoietic_system1.69865775
37MP0002210_abnormal_sex_determination1.67470414
38MP0003984_embryonic_growth_retardation1.66591400
39MP0002088_abnormal_embryonic_growth/wei1.63582560
40MP0001661_extended_life_span1.55190098
41MP0001929_abnormal_gametogenesis1.54826681
42MP0003938_abnormal_ear_development1.54120350
43MP0002653_abnormal_ependyma_morphology1.53482019
44MP0001697_abnormal_embryo_size1.52359458
45* MP0005395_other_phenotype1.50831570
46MP0002085_abnormal_embryonic_tissue1.46373749
47MP0001145_abnormal_male_reproductive1.45966158
48MP0003878_abnormal_ear_physiology1.44756005
49MP0005377_hearing/vestibular/ear_phenot1.44756005
50MP0002080_prenatal_lethality1.44503710
51MP0000653_abnormal_sex_gland1.41794583
52MP0005647_abnormal_sex_gland1.37060202
53MP0010307_abnormal_tumor_latency1.36134655
54MP0003646_muscle_fatigue1.34464858
55MP0000566_synostosis1.31515639
56MP0004264_abnormal_extraembryonic_tissu1.23422199
57MP0002102_abnormal_ear_morphology1.22831233
58MP0005646_abnormal_pituitary_gland1.21270605
59MP0002796_impaired_skin_barrier1.21105442
60MP0001119_abnormal_female_reproductive1.20500601
61MP0003252_abnormal_bile_duct1.19944884
62MP0002086_abnormal_extraembryonic_tissu1.19630482
63MP0009333_abnormal_splenocyte_physiolog1.18235868
64MP0000762_abnormal_tongue_morphology1.17654071
65MP0001542_abnormal_bone_strength1.17568986
66MP0003221_abnormal_cardiomyocyte_apopto1.17282282
67MP0003937_abnormal_limbs/digits/tail_de1.17277677
68MP0000750_abnormal_muscle_regeneration1.17038726
69MP0002084_abnormal_developmental_patter1.16418932
70MP0000631_abnormal_neuroendocrine_gland1.15858580
71* MP0003699_abnormal_female_reproductive1.14772607
72MP0009379_abnormal_foot_pigmentation1.14100566
73MP0005085_abnormal_gallbladder_physiolo1.10669491
74MP0001984_abnormal_olfaction1.09804983
75MP0000313_abnormal_cell_death1.09438992
76MP0002233_abnormal_nose_morphology1.07478339
77MP0003941_abnormal_skin_development1.05445867
78MP0006035_abnormal_mitochondrial_morpho1.03474059
79MP0003121_genomic_imprinting1.02591271
80MP0000427_abnormal_hair_cycle0.98075758
81MP0005389_reproductive_system_phenotype0.97381295
82MP0003567_abnormal_fetal_cardiomyocyte0.96655518
83MP0009672_abnormal_birth_weight0.96169981
84MP0005621_abnormal_cell_physiology0.94867139
85MP0005423_abnormal_somatic_nervous0.92943690
86MP0005384_cellular_phenotype0.92008330
87MP0000627_abnormal_mammary_gland0.91009340
88MP0001756_abnormal_urination0.89624906
89MP0000358_abnormal_cell_content/0.89287279
90MP0002019_abnormal_tumor_incidence0.88091094
91* MP0002161_abnormal_fertility/fecundity0.87660673
92MP0004142_abnormal_muscle_tone0.84722087
93MP0000428_abnormal_craniofacial_morphol0.82985314
94MP0004084_abnormal_cardiac_muscle0.82119222
95MP0003698_abnormal_male_reproductive0.81486300
96MP0005501_abnormal_skin_physiology0.80970299
97MP0002277_abnormal_respiratory_mucosa0.79899203
98MP0001293_anophthalmia0.79201990
99MP0010678_abnormal_skin_adnexa0.77497481
100MP0000647_abnormal_sebaceous_gland0.77309474
101MP0000490_abnormal_crypts_of0.77242268
102MP0002160_abnormal_reproductive_system0.76974711
103MP0000049_abnormal_middle_ear0.75366461
104MP0001666_abnormal_nutrient_absorption0.74851437
105MP0002132_abnormal_respiratory_system0.74631817
106MP0005551_abnormal_eye_electrophysiolog0.74279586
107MP0003186_abnormal_redox_activity0.74058848
108MP0005397_hematopoietic_system_phenotyp0.73490320
109MP0001545_abnormal_hematopoietic_system0.73490320
110MP0009703_decreased_birth_body0.73359802
111MP0004019_abnormal_vitamin_homeostasis0.72236909
112MP0005408_hypopigmentation0.72044322
113MP0001919_abnormal_reproductive_system0.71913770
114MP0003136_yellow_coat_color0.71047122
115MP0006276_abnormal_autonomic_nervous0.70791390
116MP0003936_abnormal_reproductive_system0.70484251
117MP0002092_abnormal_eye_morphology0.66966637
118MP0001324_abnormal_eye_pigmentation0.64798995
119MP0004197_abnormal_fetal_growth/weight/0.64671772
120MP0000383_abnormal_hair_follicle0.64641641
121MP0002272_abnormal_nervous_system0.64182198
122MP0003879_abnormal_hair_cell0.63531292
123MP0010368_abnormal_lymphatic_system0.61744969
124MP0001727_abnormal_embryo_implantation0.61734691
125MP0003755_abnormal_palate_morphology0.60698488
126MP0006036_abnormal_mitochondrial_physio0.60498329
127MP0003890_abnormal_embryonic-extraembry0.60461614
128MP0003119_abnormal_digestive_system0.60156317
129MP0000015_abnormal_ear_pigmentation0.57331064
130MP0002163_abnormal_gland_morphology0.57089263
131MP0002269_muscular_atrophy0.56688458
132MP0002127_abnormal_cardiovascular_syste0.56413848
133MP0005075_abnormal_melanosome_morpholog0.55827758
134MP0000432_abnormal_head_morphology0.52108857
135MP0002111_abnormal_tail_morphology0.52041028
136MP0005332_abnormal_amino_acid0.50863091
137MP0008995_early_reproductive_senescence0.50424610
138MP0002090_abnormal_vision0.50159038
139MP0010352_gastrointestinal_tract_polyps0.50152984
140MP0006138_congestive_heart_failure0.48547444
141MP0003935_abnormal_craniofacial_develop0.47720032
142MP0000678_abnormal_parathyroid_gland0.46313510
143MP0002751_abnormal_autonomic_nervous0.44477180
144MP0001963_abnormal_hearing_physiology0.43455058
145MP0001664_abnormal_digestion0.41355628
146MP0002873_normal_phenotype0.41333540
147MP0002169_no_abnormal_phenotype0.40919165
148MP0001881_abnormal_mammary_gland0.39212177
149MP0003868_abnormal_feces_composition0.38914967
150MP0001502_abnormal_circadian_rhythm0.38225108
151MP0002638_abnormal_pupillary_reflex0.37953117

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.73579097
2Breast hypoplasia (HP:0003187)5.62243624
3Impulsivity (HP:0100710)5.05383343
4Abnormality of abdominal situs (HP:0011620)4.93841338
5Abdominal situs inversus (HP:0003363)4.93841338
6Carpal bone hypoplasia (HP:0001498)4.88999391
7Osteomalacia (HP:0002749)4.79223749
8Hyperglycinemia (HP:0002154)4.63877929
9Cerebral hypomyelination (HP:0006808)4.54097022
10Hypoplasia of the fovea (HP:0007750)4.33209762
11Aplasia/Hypoplasia of the fovea (HP:0008060)4.33209762
12Cholecystitis (HP:0001082)4.23857627
13Abnormal gallbladder physiology (HP:0012438)4.23857627
14Septo-optic dysplasia (HP:0100842)4.17511323
15Absent septum pellucidum (HP:0001331)4.17294828
16Patellar aplasia (HP:0006443)4.16534984
17Hypophosphatemic rickets (HP:0004912)4.16210399
18Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)4.13866418
19Malnutrition (HP:0004395)4.12052291
20Aplasia/Hypoplasia of the patella (HP:0006498)4.07578987
21Rough bone trabeculation (HP:0100670)4.00952632
22Hyperglycinuria (HP:0003108)3.93676207
23Abnormality of the septum pellucidum (HP:0007375)3.82944334
24Short tibia (HP:0005736)3.81924974
25Multiple enchondromatosis (HP:0005701)3.77311957
26Abnormality of the fovea (HP:0000493)3.74216978
27Chromosomal breakage induced by crosslinking agents (HP:0003221)3.72359765
28Lip pit (HP:0100267)3.72174289
29Abnormality of the labia minora (HP:0012880)3.71096045
30Median cleft lip (HP:0000161)3.71020298
31Secondary amenorrhea (HP:0000869)3.69301628
32Premature ovarian failure (HP:0008209)3.56825509
33Chromsome breakage (HP:0040012)3.51859862
34Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.50611312
35Aplasia/Hypoplasia of the tibia (HP:0005772)3.37803596
36Papillary thyroid carcinoma (HP:0002895)3.30226388
37Infertility (HP:0000789)3.27913434
38Male infertility (HP:0003251)3.27867002
39Meckel diverticulum (HP:0002245)3.24443180
40Gonadotropin excess (HP:0000837)3.24020400
41Ureteral duplication (HP:0000073)3.22916116
42Gout (HP:0001997)3.20237634
43Absent radius (HP:0003974)3.20041793
44Anterior segment dysgenesis (HP:0007700)3.07020635
45Abnormality of serine family amino acid metabolism (HP:0010894)3.06163077
46Abnormality of glycine metabolism (HP:0010895)3.06163077
47Absent forearm bone (HP:0003953)3.00788837
48Aplasia involving forearm bones (HP:0009822)3.00788837
49Progressive muscle weakness (HP:0003323)2.99154516
50Abnormal trabecular bone morphology (HP:0100671)2.98949083
51Aplasia/Hypoplasia involving the musculature (HP:0001460)2.98048298
52Abnormality of the ileum (HP:0001549)2.97000149
53Entropion (HP:0000621)2.95596772
54Abnormality of the preputium (HP:0100587)2.95244913
55Abnormality of the umbilical cord (HP:0010881)2.88788516
56Wrist flexion contracture (HP:0001239)2.88609832
57Oligodactyly (hands) (HP:0001180)2.88059799
58CNS hypomyelination (HP:0003429)2.86362986
59Enlarged penis (HP:0000040)2.84953565
60Abnormal spermatogenesis (HP:0008669)2.74371226
61Abnormality of the anterior horn cell (HP:0006802)2.73929573
62Degeneration of anterior horn cells (HP:0002398)2.73929573
63Abnormality of the phalanges of the hallux (HP:0010057)2.72169806
64Tetraplegia (HP:0002445)2.69463556
65Proximal tubulopathy (HP:0000114)2.68507833
66Aplasia/Hypoplasia of the macula (HP:0008059)2.66892193
67Abnormal lung lobation (HP:0002101)2.66037441
68Sensory axonal neuropathy (HP:0003390)2.65524532
69Intrahepatic cholestasis (HP:0001406)2.63510468
70Fair hair (HP:0002286)2.62366251
71Microretrognathia (HP:0000308)2.62102196
72Areflexia of lower limbs (HP:0002522)2.56384798
73Sparse eyelashes (HP:0000653)2.56103968
74Urethral obstruction (HP:0000796)2.55257156
75Aplasia/Hypoplasia of the uvula (HP:0010293)2.53263629
76Hypokinesia (HP:0002375)2.52979740
77Facial hemangioma (HP:0000329)2.52653086
78Abnormality of chromosome stability (HP:0003220)2.52112048
79Oral leukoplakia (HP:0002745)2.48534181
80Abnormality of serum amino acid levels (HP:0003112)2.48215353
81Testicular atrophy (HP:0000029)2.47702010
82Breast aplasia (HP:0100783)2.47339587
83Oligodactyly (HP:0012165)2.46040684
84Muscle stiffness (HP:0003552)2.45373247
85Aplasia/Hypoplasia affecting the retina (HP:0008061)2.43176412
86Delusions (HP:0000746)2.41624315
87Spinal muscular atrophy (HP:0007269)2.40134032
88Skin pits (HP:0100276)2.39700185
89Aplasia/Hypoplasia of the breasts (HP:0010311)2.38593652
90Horseshoe kidney (HP:0000085)2.38239289
91Conjunctival telangiectasia (HP:0000524)2.37659523
92Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.37461250
93Death in infancy (HP:0001522)2.37380673
94Irregular epiphyses (HP:0010582)2.37064107
95Hypoplasia of the capital femoral epiphysis (HP:0003090)2.36382848
96Bone marrow hypocellularity (HP:0005528)2.36029489
97Atrioventricular block (HP:0001678)2.35874616
98Posterior subcapsular cataract (HP:0007787)2.35322388
99Shawl scrotum (HP:0000049)2.30936469
100Duodenal stenosis (HP:0100867)2.30655863
101Small intestinal stenosis (HP:0012848)2.30655863
102Flat capital femoral epiphysis (HP:0003370)2.29515290
103Aplasia of the musculature (HP:0100854)2.27393463
104Azoospermia (HP:0000027)2.24788666
105Aplastic anemia (HP:0001915)2.24447258
106Capillary hemangiomas (HP:0005306)2.21619646
107Trismus (HP:0000211)2.21435998
108Personality changes (HP:0000751)2.20722494
109Maternal diabetes (HP:0009800)2.19762315
110Abnormality of monocarboxylic acid metabolism (HP:0010996)2.19480596
111Metaphyseal irregularity (HP:0003025)2.19019171
112Dysautonomia (HP:0002459)2.18895846
113Generalized aminoaciduria (HP:0002909)2.15677405
114Aplasia/hypoplasia of the humerus (HP:0006507)2.15600061
115Increased circulating renin level (HP:0000848)2.15395616
116Aplasia/Hypoplasia of the earlobes (HP:0009906)2.12292077
117Congenital, generalized hypertrichosis (HP:0004540)2.11750189
118Cleft eyelid (HP:0000625)2.11684544
119Stillbirth (HP:0003826)2.10648532
120Bicornuate uterus (HP:0000813)2.08527881
121Aplasia/Hypoplasia of the tongue (HP:0010295)2.07266700
122Absent hand (HP:0004050)2.05838327
123Bundle branch block (HP:0011710)2.05517932
124Apathy (HP:0000741)2.04393526
125Abnormalities of placenta or umbilical cord (HP:0001194)2.01389210
126Spinal cord compression (HP:0002176)2.00678967
127Diminished motivation (HP:0000745)1.99231776
128Anhidrosis (HP:0000970)1.99208847
129Periauricular skin pits (HP:0100277)1.98826020
130Preauricular pit (HP:0004467)1.98826020
131Rhinitis (HP:0012384)1.98686093
132Atrophy/Degeneration involving motor neurons (HP:0007373)1.98509009
133Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.98346068
134Abnormality of alanine metabolism (HP:0010916)1.98346068
135Hyperalaninemia (HP:0003348)1.98346068
136Fused cervical vertebrae (HP:0002949)1.98050084
137Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.97913453
138Abnormality of aromatic amino acid family metabolism (HP:0004338)1.97787465
139Short nail (HP:0001799)1.97638519
140Abnormality of the distal phalanges of the toes (HP:0010182)1.97298083
141Abnormal ciliary motility (HP:0012262)1.96422893
142Pancreatic fibrosis (HP:0100732)1.96013807
143Heterotopia (HP:0002282)1.95758130
144Ventricular fibrillation (HP:0001663)1.95477970
145Adrenal hypoplasia (HP:0000835)1.94551755
146Megaloblastic anemia (HP:0001889)1.93741217
147Steatorrhea (HP:0002570)1.93524113
148Hyperglycemia (HP:0003074)1.92675292
149Supernumerary spleens (HP:0009799)1.92062185
150Ankle contracture (HP:0006466)1.91032336
151Sparse lateral eyebrow (HP:0005338)1.89543095
152Nephroblastoma (Wilms tumor) (HP:0002667)1.86982043
153Premature rupture of membranes (HP:0001788)1.85681990
154Limb hypertonia (HP:0002509)1.85409927
155Glucose intolerance (HP:0000833)1.85274737
156Bile duct proliferation (HP:0001408)1.84082283
157Abnormal biliary tract physiology (HP:0012439)1.84082283
158Nausea (HP:0002018)1.82823764
159Generalized hypopigmentation of hair (HP:0011358)1.82620052
160Thyroid carcinoma (HP:0002890)1.82491058
161Hypoplasia of the uterus (HP:0000013)1.82459984
162Aplasia/hypoplasia of the uterus (HP:0008684)1.81999247
163Abnormality of glycolipid metabolism (HP:0010969)1.81559558
164Abnormality of liposaccharide metabolism (HP:0010968)1.81559558
165Abnormality of glycosphingolipid metabolism (HP:0004343)1.81559558
166Abnormality of the vasculature of the conjunctiva (HP:0008054)1.81558845
167Congenital sensorineural hearing impairment (HP:0008527)1.80872211
168Myelodysplasia (HP:0002863)1.80451163
169Pustule (HP:0200039)1.80406211
170Sloping forehead (HP:0000340)1.80245239
171Hip contracture (HP:0003273)1.79794781
172Rickets (HP:0002748)1.77054640
173Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.76466651

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.76585698
2MAP3K135.24183135
3WEE15.02549407
4PLK43.64128626
5EIF2AK13.01208204
6TTK2.92482718
7SRPK12.88797423
8AKT32.74781340
9BRSK22.64340533
10TSSK62.62511322
11NEK22.57638048
12TAOK32.44392410
13PBK2.43577764
14EPHA22.40835741
15PLK12.39071777
16CDK92.38201074
17PLK32.24378572
18LATS22.15185134
19PNCK2.08061189
20NEK11.97653276
21KSR21.95737670
22MET1.93209883
23STK391.91001155
24STK161.90401870
25BRSK11.82250259
26EIF2AK31.81576351
27STK38L1.78992564
28PINK11.74164261
29CDC71.68231341
30CHEK21.65261868
31ARAF1.65247427
32MST41.64428454
33MKNK21.58006562
34ACVR1B1.53856476
35NME21.49337543
36IRAK31.47703242
37TRIM281.47417261
38AURKB1.42641473
39ZAK1.42183450
40DYRK31.38203918
41BRAF1.36700545
42TNIK1.32873160
43STK31.27517314
44CCNB11.25048115
45PDK41.25023177
46PDK31.25023177
47AURKA1.22474593
48CDK121.17334113
49NTRK21.17309232
50MKNK11.17179972
51OXSR11.16811537
52KSR11.16363904
53LATS11.13706390
54VRK11.08365436
55CDK71.03710439
56CHEK11.03580899
57CDK191.00660878
58ALK1.00087520
59PDK20.96645328
60EIF2AK20.95487177
61WNK40.95370753
62MAP3K80.88489374
63NUAK10.88017319
64NEK90.87915452
65TIE10.85243594
66DYRK20.84993017
67PRKCI0.84450762
68TESK20.80039484
69CDK40.73202391
70PIM20.70298072
71CDK20.70053091
72MELK0.69135173
73NME10.68803211
74BMPR1B0.68664790
75GRK50.67693068
76STK240.67518257
77MAP3K90.66629847
78RAF10.66431851
79ATR0.65673971
80PAK10.65164384
81ABL20.61716047
82DMPK0.60823287
83CDK30.57692592
84MAP3K60.57371748
85CDK10.54834913
86STK100.54359101
87CSNK1E0.53985087
88PKN10.53646175
89MOS0.53140969
90PRKG10.52208150
91ATM0.52192741
92PRKAA10.50299203
93LMTK20.50092604
94RPS6KA40.49869200
95STK380.49226883
96CSNK2A10.49194339
97CSNK1G30.47116285
98GRK10.45608869
99NTRK30.43178092
100TNK20.42280924
101STK40.41345100
102CSNK1D0.41086274
103CSNK2A20.39709153
104TAOK10.39438741
105MAP3K50.39235572
106PIM10.39144998
107CSNK1G10.39114740
108WNK10.38763288
109NEK60.38744845
110MAPKAPK30.38365607
111TGFBR10.37604235
112MUSK0.34211709
113LRRK20.34009969
114ERBB40.33740274
115PTK20.32506216
116RPS6KB20.31621235
117PRKACB0.30297146
118CAMK2A0.29707190
119WNK30.27604784
120PRKCG0.27481909
121PRKACA0.26187706
122CSNK1A10.25547095
123EGFR0.25354007
124CSNK1G20.25266441
125MARK10.25001573
126CSNK1A1L0.23603062
127CDK80.22853256
128PRKCZ0.22807763
129MAPK10.22610899
130MARK30.22096088
131MAPK100.21326365
132MAPK130.20940148
133BMPR20.20894964
134PAK40.18478459
135MTOR0.18332423
136TYRO30.17579875
137TLK10.15234848
138GSK3B0.13523761
139AKT20.12986651
140RPS6KA50.11621532

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007506.65453382
2RNA polymerase_Homo sapiens_hsa030205.12575252
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.79032209
4Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005334.06228001
5Proteasome_Homo sapiens_hsa030503.74588253
6RNA transport_Homo sapiens_hsa030133.45679992
7Caffeine metabolism_Homo sapiens_hsa002322.96343944
8Cell cycle_Homo sapiens_hsa041102.81729982
9Pyrimidine metabolism_Homo sapiens_hsa002402.64312152
10Basal transcription factors_Homo sapiens_hsa030222.60711487
11DNA replication_Homo sapiens_hsa030302.57461397
12Regulation of autophagy_Homo sapiens_hsa041402.43388922
13Spliceosome_Homo sapiens_hsa030402.41211906
14Homologous recombination_Homo sapiens_hsa034402.36083641
15Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.21027498
16Mismatch repair_Homo sapiens_hsa034302.12983236
17Fanconi anemia pathway_Homo sapiens_hsa034602.05943820
18Nucleotide excision repair_Homo sapiens_hsa034201.95810576
19p53 signaling pathway_Homo sapiens_hsa041151.78409175
20Purine metabolism_Homo sapiens_hsa002301.73009314
21Dorso-ventral axis formation_Homo sapiens_hsa043201.72630545
22Base excision repair_Homo sapiens_hsa034101.70986672
23Folate biosynthesis_Homo sapiens_hsa007901.70349262
24Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.69599741
25Ribosome_Homo sapiens_hsa030101.68104090
26Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.68089353
27Pentose phosphate pathway_Homo sapiens_hsa000301.66990721
28RNA degradation_Homo sapiens_hsa030181.61868594
29Olfactory transduction_Homo sapiens_hsa047401.61799162
30Oocyte meiosis_Homo sapiens_hsa041141.50037218
31Glycerophospholipid metabolism_Homo sapiens_hsa005641.44055977
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.41813149
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.27621322
34Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.26916041
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.26629832
36mRNA surveillance pathway_Homo sapiens_hsa030151.24015346
37Epstein-Barr virus infection_Homo sapiens_hsa051691.21241582
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.20922051
39Fructose and mannose metabolism_Homo sapiens_hsa000511.14546981
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.12054966
41Synaptic vesicle cycle_Homo sapiens_hsa047211.11772703
42Collecting duct acid secretion_Homo sapiens_hsa049661.09497260
43Drug metabolism - other enzymes_Homo sapiens_hsa009831.04092101
44SNARE interactions in vesicular transport_Homo sapiens_hsa041301.04019853
45One carbon pool by folate_Homo sapiens_hsa006701.01521156
46Vitamin digestion and absorption_Homo sapiens_hsa049771.00857385
47Phototransduction_Homo sapiens_hsa047440.99095526
48Fatty acid elongation_Homo sapiens_hsa000620.98819955
49Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.97103816
50Circadian rhythm_Homo sapiens_hsa047100.81815001
51Biosynthesis of amino acids_Homo sapiens_hsa012300.81080628
52Linoleic acid metabolism_Homo sapiens_hsa005910.76903387
53Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.76774369
54Nicotine addiction_Homo sapiens_hsa050330.76494564
55Gap junction_Homo sapiens_hsa045400.74516379
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72614744
57Arachidonic acid metabolism_Homo sapiens_hsa005900.69880967
58Non-homologous end-joining_Homo sapiens_hsa034500.69645873
59ABC transporters_Homo sapiens_hsa020100.68509192
60alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.60374147
61Taste transduction_Homo sapiens_hsa047420.59050186
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.58758033
63Glutathione metabolism_Homo sapiens_hsa004800.51106312
64Bile secretion_Homo sapiens_hsa049760.49410679
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48099059
66Metabolic pathways_Homo sapiens_hsa011000.47304167
67mTOR signaling pathway_Homo sapiens_hsa041500.46461240
68Sulfur relay system_Homo sapiens_hsa041220.45476496
69Protein export_Homo sapiens_hsa030600.42626589
70Propanoate metabolism_Homo sapiens_hsa006400.40865426
71Carbon metabolism_Homo sapiens_hsa012000.40756679
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39653409
73Morphine addiction_Homo sapiens_hsa050320.39192648
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.39013078
75Arginine and proline metabolism_Homo sapiens_hsa003300.37771106
76Cardiac muscle contraction_Homo sapiens_hsa042600.36290390
77Sphingolipid metabolism_Homo sapiens_hsa006000.35979481
78Selenocompound metabolism_Homo sapiens_hsa004500.35521126
79Ether lipid metabolism_Homo sapiens_hsa005650.34721622
80Galactose metabolism_Homo sapiens_hsa000520.33820971
81GABAergic synapse_Homo sapiens_hsa047270.32688051
82Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.31527688
83FoxO signaling pathway_Homo sapiens_hsa040680.30343266
84Long-term depression_Homo sapiens_hsa047300.30235160
85Parkinsons disease_Homo sapiens_hsa050120.29751439
86Viral carcinogenesis_Homo sapiens_hsa052030.29247773
87Glycerolipid metabolism_Homo sapiens_hsa005610.28634840
882-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.27382816
89Herpes simplex infection_Homo sapiens_hsa051680.27381147
90Huntingtons disease_Homo sapiens_hsa050160.26784347
91Adherens junction_Homo sapiens_hsa045200.26742281
92Antigen processing and presentation_Homo sapiens_hsa046120.26229060
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.26127401
94Vibrio cholerae infection_Homo sapiens_hsa051100.24668247
95Serotonergic synapse_Homo sapiens_hsa047260.23021848
96MicroRNAs in cancer_Homo sapiens_hsa052060.22340483
97Wnt signaling pathway_Homo sapiens_hsa043100.21735145
98Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.20744386
99Oxidative phosphorylation_Homo sapiens_hsa001900.20675488
100Hippo signaling pathway_Homo sapiens_hsa043900.18052174
101HTLV-I infection_Homo sapiens_hsa051660.17810408
102Cyanoamino acid metabolism_Homo sapiens_hsa004600.17731093
103Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.16791279
104beta-Alanine metabolism_Homo sapiens_hsa004100.14493119
105Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.14152232
106Thyroid cancer_Homo sapiens_hsa052160.13862235
107TGF-beta signaling pathway_Homo sapiens_hsa043500.13496359
108Renal cell carcinoma_Homo sapiens_hsa052110.13456713
109Pyruvate metabolism_Homo sapiens_hsa006200.12485810
110Inositol phosphate metabolism_Homo sapiens_hsa005620.12116896
111Renin-angiotensin system_Homo sapiens_hsa046140.11242708
112Lysosome_Homo sapiens_hsa041420.10786351
113Glycosaminoglycan degradation_Homo sapiens_hsa005310.10586450
114Mineral absorption_Homo sapiens_hsa049780.10129388
115Protein digestion and absorption_Homo sapiens_hsa049740.09070215
116Ovarian steroidogenesis_Homo sapiens_hsa049130.09059337
117Small cell lung cancer_Homo sapiens_hsa052220.08966001
118Pentose and glucuronate interconversions_Homo sapiens_hsa000400.08809292
119Retinol metabolism_Homo sapiens_hsa008300.08178447
120Intestinal immune network for IgA production_Homo sapiens_hsa046720.06335217
121cGMP-PKG signaling pathway_Homo sapiens_hsa040220.05022226
122Ras signaling pathway_Homo sapiens_hsa040140.04652477
123Phagosome_Homo sapiens_hsa041450.04471255
124Hedgehog signaling pathway_Homo sapiens_hsa043400.04416341
125Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.03657334
126Tight junction_Homo sapiens_hsa045300.03586481
127Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.03329826
128Steroid biosynthesis_Homo sapiens_hsa001000.02095073
129HIF-1 signaling pathway_Homo sapiens_hsa040660.01481353
130Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.01249452
131Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.01111533
132Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.00967784
133Maturity onset diabetes of the young_Homo sapiens_hsa049500.00751880
134Thyroid hormone signaling pathway_Homo sapiens_hsa049190.00186446
135Butanoate metabolism_Homo sapiens_hsa006500.00013768
136Pathways in cancer_Homo sapiens_hsa05200-0.0635994
137Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.0499701
138Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760-0.0447733
139Choline metabolism in cancer_Homo sapiens_hsa05231-0.0263706
140NOD-like receptor signaling pathway_Homo sapiens_hsa04621-0.0175354
141AMPK signaling pathway_Homo sapiens_hsa04152-0.0132681

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