ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	9.56664519
2	regulation of retinoic acid receptor signaling pathway (GO:0048385)	8.33196122
3	regulation of meiosis I (GO:0060631)	8.16808259
4	piRNA metabolic process (GO:0034587)	7.96625141
5	regulation of female gonad development (GO:2000194)	7.05334367
6	meiotic cell cycle (GO:0051321)	6.54054872
7	mitotic metaphase plate congression (GO:0007080)	5.80383845
8	DNA methylation involved in gamete generation (GO:0043046)	5.78992163
9	female gamete generation (GO:0007292)	5.68684870
10	glycine transport (GO:0015816)	5.55072363
11	oocyte development (GO:0048599)	5.36236494
12	synapsis (GO:0007129)	5.28458341
13	male meiosis I (GO:0007141)	5.16235790
14	mitotic chromosome condensation (GO:0007076)	4.99095500
15	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	4.89905987
16	positive regulation of chromosome segregation (GO:0051984)	4.84128063
17	CENP-A containing nucleosome assembly (GO:0034080)	4.82899048
18	gene silencing by RNA (GO:0031047)	4.80717303
19	positive regulation of histone H3-K4 methylation (GO:0051571)	4.76454881
20	metaphase plate congression (GO:0051310)	4.65741984
21	pyrimidine-containing compound transmembrane transport (GO:0072531)	4.63547268
22	protein localization to chromosome, centromeric region (GO:0071459)	4.62956750
23	regulation of histone H3-K9 methylation (GO:0051570)	4.58631720
24	retinal cone cell development (GO:0046549)	4.55661744
25	regulation of acrosome reaction (GO:0060046)	4.55111842
26	regulation of cell maturation (GO:1903429)	4.43576256
27	chromatin remodeling at centromere (GO:0031055)	4.41261645
28	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	4.39914323
29	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	4.39914323
30	positive regulation of mitotic sister chromatid separation (GO:1901970)	4.39914323
31	regulation of spindle organization (GO:0090224)	4.38832239
32	establishment of chromosome localization (GO:0051303)	4.37866817
33	male meiosis (GO:0007140)	4.36584752
34	meiosis I (GO:0007127)	4.31607138
35	multicellular organism reproduction (GO:0032504)	4.29436770
36	chromosome organization involved in meiosis (GO:0070192)	4.25018319
37	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	4.23668350
38	positive regulation of gastrulation (GO:2000543)	4.10185272
39	synaptonemal complex assembly (GO:0007130)	4.05428926
40	protein localization to kinetochore (GO:0034501)	4.04237450
41	primitive streak formation (GO:0090009)	4.04027123
42	regulation of meiosis (GO:0040020)	4.01952819
43	L-amino acid import (GO:0043092)	3.99971973
44	meiotic nuclear division (GO:0007126)	3.96312208
45	histone exchange (GO:0043486)	3.89073160
46	regulation of steroid hormone secretion (GO:2000831)	3.88583644
47	negative regulation of reproductive process (GO:2000242)	3.86960834
48	centriole replication (GO:0007099)	3.81395255
49	meiotic cell cycle process (GO:1903046)	3.78834504
50	oogenesis (GO:0048477)	3.78319908
51	regulation of double-strand break repair via homologous recombination (GO:0010569)	3.76790741
52	labyrinthine layer development (GO:0060711)	3.74888907
53	DNA replication-independent nucleosome assembly (GO:0006336)	3.73353790
54	DNA replication-independent nucleosome organization (GO:0034724)	3.73353790
55	synaptonemal complex organization (GO:0070193)	3.65491672
56	positive regulation of uterine smooth muscle contraction (GO:0070474)	3.62326609
57	attachment of spindle microtubules to kinetochore (GO:0008608)	3.61783395
58	negative regulation of histone methylation (GO:0031061)	3.60160697
59	hyperosmotic salinity response (GO:0042538)	3.57985121
60	nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)	3.47955478
61	N-terminal protein amino acid acetylation (GO:0006474)	3.42650322
62	translesion synthesis (GO:0019985)	3.41362555
63	protein localization to chromosome (GO:0034502)	3.40631098
64	regulation of meiotic cell cycle (GO:0051445)	3.39219802
65	DNA replication checkpoint (GO:0000076)	3.37311388
66	somite rostral/caudal axis specification (GO:0032525)	3.31513928
67	negative regulation of execution phase of apoptosis (GO:1900118)	3.29920837
68	DNA replication-dependent nucleosome organization (GO:0034723)	3.22942342
69	DNA replication-dependent nucleosome assembly (GO:0006335)	3.22942342
70	DNA methylation (GO:0006306)	3.16098245
71	DNA alkylation (GO:0006305)	3.16098245
72	oocyte maturation (GO:0001556)	3.12785439
73	regulation of mitotic spindle organization (GO:0060236)	3.12639894
74	regulation of spindle checkpoint (GO:0090231)	3.10465534
75	ventricular cardiac muscle cell development (GO:0055015)	3.07033717
76	transcription elongation from RNA polymerase I promoter (GO:0006362)	3.05679696
77	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	3.05581138
78	proteasome assembly (GO:0043248)	3.00988718
79	amino acid import (GO:0043090)	2.98913089
80	termination of RNA polymerase I transcription (GO:0006363)	2.98744499
81	protein K6-linked ubiquitination (GO:0085020)	2.98607912
82	gene silencing (GO:0016458)	2.95142088
83	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.93906516
84	spermatid nucleus differentiation (GO:0007289)	2.92262325
85	paraxial mesoderm development (GO:0048339)	2.89658220
86	DNA damage induced protein phosphorylation (GO:0006975)	2.86580797
87	chromatin assembly or disassembly (GO:0006333)	2.85805572
88	nucleotide-excision repair, DNA gap filling (GO:0006297)	2.85560280
89	positive regulation of reproductive process (GO:2000243)	2.82369467
90	aggressive behavior (GO:0002118)	2.81657602
91	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	2.81196830
92	sister chromatid cohesion (GO:0007062)	2.80929410
93	chromosome segregation (GO:0007059)	2.80675364
94	regulation of histone H3-K4 methylation (GO:0051569)	2.79465758
95	telomere maintenance via semi-conservative replication (GO:0032201)	2.78616175
96	positive regulation of meiotic cell cycle (GO:0051446)	2.78164648
97	positive regulation of meiosis (GO:0045836)	2.77765889
98	positive regulation of histone methylation (GO:0031062)	2.77645450
99	regulation of female receptivity (GO:0045924)	2.77349483
100	regulation of DNA methylation (GO:0044030)	11.0228598

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	8.52697369
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	5.32652225
3	E2F7_22180533_ChIP-Seq_HELA_Human	4.80330063
4	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	4.27280348
5	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	4.27280348
6	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	4.27280348
7	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.50239268
8	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	3.34099683
9	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.23211207
10	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.10142717
11	FOXM1_23109430_ChIP-Seq_U2OS_Human	3.10061863
12	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	3.08028856
13	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.05543709
14	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.91731009
15	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.91432908
16	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.86589705
17	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.81594304
18	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.31285605
19	AR_21909140_ChIP-Seq_LNCAP_Human	2.25893682
20	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.21058252
21	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.16715884
22	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	2.09690930
23	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.07106702
24	IRF1_19129219_ChIP-ChIP_H3396_Human	2.04322783
25	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.01307309
26	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.99210792
27	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.94085173
28	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.85248149
29	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.80573417
30	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.53435981
31	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.53324366
32	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.50298762
33	ZNF274_21170338_ChIP-Seq_K562_Hela	1.44891644
34	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.37827811
35	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.28345064
36	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	1.27843417
37	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.26911753
38	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.26890839
39	HTT_18923047_ChIP-ChIP_STHdh_Human	1.25787385
40	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.23388599
41	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.23028658
42	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.21588904
43	FOXP3_21729870_ChIP-Seq_TREG_Human	1.20689872
44	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.19751454
45	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.18100506
46	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.17999613
47	VDR_23849224_ChIP-Seq_CD4+_Human	1.17833058
48	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.17823392
49	CBP_20019798_ChIP-Seq_JUKART_Human	1.14485795
50	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.14485795
51	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.13180475
52	GBX2_23144817_ChIP-Seq_PC3_Human	1.10268798
53	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.09468399
54	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.05792161
55	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.05300976
56	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.05108304
57	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.04623742
58	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.03239311
59	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.02743834
60	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.00288231
61	VDR_22108803_ChIP-Seq_LS180_Human	1.00197355
62	NANOG_20526341_ChIP-Seq_ESCs_Human	0.99690009
63	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.97959976
64	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.96884715
65	EWS_26573619_Chip-Seq_HEK293_Human	0.92411905
66	TP53_22573176_ChIP-Seq_HFKS_Human	0.91962796
67	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	0.91464114
68	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.88534373
69	TCF4_23295773_ChIP-Seq_U87_Human	0.87868979
70	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.85077604
71	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.84334006
72	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.83359781
73	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.81845650
74	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	0.81276450
75	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.80869400
76	CBP_21632823_ChIP-Seq_H3396_Human	0.80067625
77	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.78896701
78	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.77200269
79	GF1_26923725_Chip-Seq_HPCs_Mouse	0.76997218
80	GABP_19822575_ChIP-Seq_HepG2_Human	0.75448178
81	EP300_21415370_ChIP-Seq_HL-1_Mouse	0.75199258
82	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.75040084
83	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.74774022
84	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.73312521
85	DCP1A_22483619_ChIP-Seq_HELA_Human	0.70626679
86	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.70176779
87	P300_19829295_ChIP-Seq_ESCs_Human	0.69540701
88	AR_25329375_ChIP-Seq_VCAP_Human	0.69168132
89	MYC_18940864_ChIP-ChIP_HL60_Human	0.67049483
90	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.67005134
91	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.66233508
92	RUNX2_22187159_ChIP-Seq_PCA_Human	0.64754654
93	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.63857944
94	AR_20517297_ChIP-Seq_VCAP_Human	0.63170685
95	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.62137634
96	AHR_22903824_ChIP-Seq_MCF-7_Human	0.61831990
97	NCOR_22424771_ChIP-Seq_293T_Human	0.61830674
98	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.60554232
99	TTF2_22483619_ChIP-Seq_HELA_Human	0.60541076
100	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	0.60307889

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003718_maternal_effect	8.26427319
2	MP0006292_abnormal_olfactory_placode	4.58209188
3	MP0008877_abnormal_DNA_methylation	4.39832350
4	MP0008789_abnormal_olfactory_epithelium	3.84271042
5	MP0003693_abnormal_embryo_hatching	3.43200543
6	MP0005499_abnormal_olfactory_system	3.34693880
7	MP0005394_taste/olfaction_phenotype	3.34693880
8	MP0003890_abnormal_embryonic-extraembry	3.26915316
9	MP0005395_other_phenotype	3.23967623
10	MP0010234_abnormal_vibrissa_follicle	2.76913570
11	MP0001986_abnormal_taste_sensitivity	2.56133701
12	MP0005360_urolithiasis	2.53778226
13	MP0003077_abnormal_cell_cycle	2.48779515
14	MP0002210_abnormal_sex_determination	2.36260279
15	MP0002139_abnormal_hepatobiliary_system	2.34000504
16	MP0008057_abnormal_DNA_replication	2.29242513
17	MP0010094_abnormal_chromosome_stability	2.28249560
18	MP0002138_abnormal_hepatobiliary_system	2.24044188
19	MP0001929_abnormal_gametogenesis	2.17413284
20	MP0003699_abnormal_female_reproductive	2.13314884
21	MP0008058_abnormal_DNA_repair	2.12956655
22	MP0003950_abnormal_plasma_membrane	2.12016103
23	MP0010030_abnormal_orbit_morphology	2.09787942
24	MP0003111_abnormal_nucleus_morphology	2.02406980
25	MP0002160_abnormal_reproductive_system	1.98799830
26	MP0003879_abnormal_hair_cell	1.89665017
27	MP0004957_abnormal_blastocyst_morpholog	1.80884040
28	MP0005410_abnormal_fertilization	1.75986295
29	MP0000653_abnormal_sex_gland	1.73850047
30	MP0002234_abnormal_pharynx_morphology	1.73378196
31	MP0008932_abnormal_embryonic_tissue	1.72192166
32	MP0001145_abnormal_male_reproductive	1.56700433
33	MP0003183_abnormal_peptide_metabolism	1.54417897
34	MP0002161_abnormal_fertility/fecundity	1.53720283
35	MP0002796_impaired_skin_barrier	1.45364371
36	MP0000566_synostosis	1.41532061
37	MP0005647_abnormal_sex_gland	1.39242922
38	MP0001730_embryonic_growth_arrest	1.36725407
39	MP0001293_anophthalmia	1.36589421
40	MP0009379_abnormal_foot_pigmentation	1.30663268
41	MP0003698_abnormal_male_reproductive	1.29838889
42	MP0005423_abnormal_somatic_nervous	1.20515530
43	MP0000350_abnormal_cell_proliferation	1.16850183
44	MP0001672_abnormal_embryogenesis/_devel	1.16641187
45	MP0005380_embryogenesis_phenotype	1.16641187
46	MP0005389_reproductive_system_phenotype	1.16339815
47	MP0005646_abnormal_pituitary_gland	1.16332045
48	MP0010307_abnormal_tumor_latency	1.16084604
49	MP0001119_abnormal_female_reproductive	1.12653267
50	MP0000631_abnormal_neuroendocrine_gland	1.12273675
51	MP0003252_abnormal_bile_duct	1.11813897
52	MP0000427_abnormal_hair_cycle	1.05797485
53	MP0004142_abnormal_muscle_tone	1.03972344
54	MP0009840_abnormal_foam_cell	1.02449441
55	MP0005085_abnormal_gallbladder_physiolo	1.00207151
56	MP0000762_abnormal_tongue_morphology	0.99496264
57	MP0003119_abnormal_digestive_system	0.99281161
58	MP0005501_abnormal_skin_physiology	0.91652071
59	MP0002127_abnormal_cardiovascular_syste	0.91224925
60	MP0002233_abnormal_nose_morphology	0.86183940
61	MP0001697_abnormal_embryo_size	0.86051094
62	MP0001984_abnormal_olfaction	0.83882363
63	MP0010678_abnormal_skin_adnexa	0.80553300
64	MP0002084_abnormal_developmental_patter	0.80194522
65	MP0006276_abnormal_autonomic_nervous	0.78921152
66	MP0000049_abnormal_middle_ear	0.78317912
67	MP0003121_genomic_imprinting	0.78110618
68	MP0003984_embryonic_growth_retardation	0.70867634
69	MP0002272_abnormal_nervous_system	0.69968205
70	MP0002088_abnormal_embryonic_growth/wei	0.68807249
71	MP0002085_abnormal_embryonic_tissue	0.67658589
72	MP0000678_abnormal_parathyroid_gland	0.65485755
73	MP0005551_abnormal_eye_electrophysiolog	0.64506401
74	MP0005075_abnormal_melanosome_morpholog	0.63665569
75	MP0003136_yellow_coat_color	0.63382127
76	MP0003567_abnormal_fetal_cardiomyocyte	0.62241394
77	MP0003646_muscle_fatigue	0.60150351
78	MP0010368_abnormal_lymphatic_system	0.59236949
79	MP0006036_abnormal_mitochondrial_physio	0.58123282
80	MP0001666_abnormal_nutrient_absorption	0.57618577
81	MP0000015_abnormal_ear_pigmentation	0.54655910
82	MP0008260_abnormal_autophagy	0.54312368
83	MP0008995_early_reproductive_senescence	0.54194831
84	MP0004019_abnormal_vitamin_homeostasis	0.53137794
85	MP0003936_abnormal_reproductive_system	0.53035601
86	MP0001324_abnormal_eye_pigmentation	0.51934510
87	MP0000313_abnormal_cell_death	0.51845037
88	MP0003186_abnormal_redox_activity	0.51731946
89	MP0006138_congestive_heart_failure	0.51018444
90	MP0002735_abnormal_chemical_nociception	0.50928608
91	MP0002080_prenatal_lethality	0.50859637
92	MP0004215_abnormal_myocardial_fiber	0.47808498
93	MP0001881_abnormal_mammary_gland	0.46881253
94	MP0001963_abnormal_hearing_physiology	0.46132848
95	MP0003941_abnormal_skin_development	0.46090844
96	MP0001502_abnormal_circadian_rhythm	0.44521400
97	MP0002098_abnormal_vibrissa_morphology	0.44327985
98	MP0003935_abnormal_craniofacial_develop	0.44100581
99	MP0003195_calcinosis	0.42892501
100	MP0002873_normal_phenotype	0.42848152

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Supernumerary spleens (HP:0009799)	6.23177613
2	Male infertility (HP:0003251)	4.58226056
3	Osteomalacia (HP:0002749)	4.54107831
4	Abnormality of abdominal situs (HP:0011620)	4.36687438
5	Abdominal situs inversus (HP:0003363)	4.36687438
6	Premature ovarian failure (HP:0008209)	4.36038370
7	Malnutrition (HP:0004395)	4.30480060
8	Azoospermia (HP:0000027)	4.24359177
9	Oligodactyly (hands) (HP:0001180)	4.04377851
10	Hypophosphatemic rickets (HP:0004912)	4.02121761
11	Aplasia/Hypoplasia of the fovea (HP:0008060)	3.95478236
12	Hypoplasia of the fovea (HP:0007750)	3.95478236
13	Facial hemangioma (HP:0000329)	3.80854308
14	Lip pit (HP:0100267)	3.70393083
15	Absent septum pellucidum (HP:0001331)	3.62462102
16	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.54178496
17	Septo-optic dysplasia (HP:0100842)	3.51789459
18	Abnormality of the labia minora (HP:0012880)	3.48311105
19	Median cleft lip (HP:0000161)	3.47933938
20	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	3.47864023
21	Abnormality of the fovea (HP:0000493)	3.46471966
22	Abnormal spermatogenesis (HP:0008669)	3.43563530
23	Gonadotropin excess (HP:0000837)	3.43138178
24	Papillary thyroid carcinoma (HP:0002895)	3.41029840
25	Chromsome breakage (HP:0040012)	3.40591151
26	Abnormality of the septum pellucidum (HP:0007375)	3.34319232
27	Infertility (HP:0000789)	3.25168702
28	Short tibia (HP:0005736)	3.21782250
29	Cholecystitis (HP:0001082)	3.20210195
30	Abnormal gallbladder physiology (HP:0012438)	3.20210195
31	Impulsivity (HP:0100710)	2.95941434
32	Muscle stiffness (HP:0003552)	2.93707545
33	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.84431375
34	Oligodactyly (HP:0012165)	2.83344819
35	Proximal tubulopathy (HP:0000114)	2.81283747
36	Urethral obstruction (HP:0000796)	2.70072394
37	Anterior segment dysgenesis (HP:0007700)	2.69446255
38	Conjunctival telangiectasia (HP:0000524)	2.68620530
39	Stillbirth (HP:0003826)	2.55829863
40	Skin pits (HP:0100276)	2.55004466
41	Sensory axonal neuropathy (HP:0003390)	2.53645118
42	Abnormal lung lobation (HP:0002101)	2.51609399
43	Generalized aminoaciduria (HP:0002909)	2.41784370
44	Multiple enchondromatosis (HP:0005701)	2.38033815
45	Fair hair (HP:0002286)	2.36838162
46	Aplasia/Hypoplasia of the macula (HP:0008059)	2.36465354
47	Ankle contracture (HP:0006466)	2.35942775
48	Wrist flexion contracture (HP:0001239)	2.35805983
49	Absent radius (HP:0003974)	2.35652262
50	Intrahepatic cholestasis (HP:0001406)	2.35057828
51	Hypoplasia of the uterus (HP:0000013)	2.34343536
52	Capillary hemangiomas (HP:0005306)	2.33232684
53	Increased circulating renin level (HP:0000848)	2.32237261
54	Aplasia of the musculature (HP:0100854)	2.28654604
55	Aplastic anemia (HP:0001915)	2.27383978
56	Rhinitis (HP:0012384)	2.27217427
57	Enlarged penis (HP:0000040)	2.25955229
58	Posterior subcapsular cataract (HP:0007787)	2.22989523
59	Absent forearm bone (HP:0003953)	2.22676263
60	Aplasia involving forearm bones (HP:0009822)	2.22676263
61	Birth length less than 3rd percentile (HP:0003561)	2.22430220
62	Preauricular pit (HP:0004467)	2.20665375
63	Periauricular skin pits (HP:0100277)	2.20665375
64	Methylmalonic acidemia (HP:0002912)	2.19934730
65	Abnormal ciliary motility (HP:0012262)	2.15274408
66	Aplasia/Hypoplasia affecting the retina (HP:0008061)	2.14686225
67	Aplasia/Hypoplasia involving the musculature (HP:0001460)	2.13559910
68	Horseshoe kidney (HP:0000085)	2.13528613
69	Abnormality of monocarboxylic acid metabolism (HP:0010996)	2.12401830
70	Abnormality of the phalanges of the hallux (HP:0010057)	2.10605119
71	Hypokinesia (HP:0002375)	2.09567414
72	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.09423730
73	Aplasia/hypoplasia of the uterus (HP:0008684)	2.07196688
74	Abnormality of the vasculature of the conjunctiva (HP:0008054)	2.06792427
75	Nausea (HP:0002018)	2.05755048
76	Metaphyseal irregularity (HP:0003025)	2.04258850
77	Bicornuate uterus (HP:0000813)	2.02315698
78	Loss of speech (HP:0002371)	2.00882563
79	Carpal bone hypoplasia (HP:0001498)	1.99312302
80	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.98926951
81	Steatorrhea (HP:0002570)	1.94930977
82	Meckel diverticulum (HP:0002245)	1.94204357
83	Abnormality of the preputium (HP:0100587)	1.93712126
84	Cleft eyelid (HP:0000625)	1.93025399
85	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.92494308
86	Thyroid carcinoma (HP:0002890)	1.89637528
87	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	1.88621236
88	Anhidrosis (HP:0000970)	1.87308785
89	Maternal diabetes (HP:0009800)	1.86957129
90	Megaloblastic anemia (HP:0001889)	1.85874940
91	Abnormality of the ileum (HP:0001549)	1.85872573
92	Abnormal respiratory motile cilium physiology (HP:0012261)	1.84924598
93	Rickets (HP:0002748)	1.80460553
94	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.79119466
95	Underdeveloped supraorbital ridges (HP:0009891)	1.78988686
96	Neurodegeneration (HP:0002180)	1.78038059
97	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.77596669
98	Hydroureter (HP:0000072)	1.74017837
99	Ureteral duplication (HP:0000073)	1.73401475
100	Hypoglycemic coma (HP:0001325)	1.69825239

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP3K9	6.03920615
2	ARAF	5.35176516
3	MAP3K13	5.24397423
4	STK24	3.04865064
5	BRAF	2.83218725
6	TTK	2.82429123
7	PBK	2.80325219
8	EIF2AK3	2.73541559
9	NEK6	2.66138657
10	TAOK3	2.30724174
11	MOS	2.30367955
12	KSR2	2.12555108
13	BUB1	2.10522402
14	STK39	1.98372203
15	AURKA	1.95994488
16	CDK19	1.92492730
17	RAF1	1.87220287
18	SRPK1	1.79757732
19	ZAK	1.64517190
20	PLK1	1.60618044
21	CDK9	1.52693078
22	TRIM28	1.52029536
23	MET	1.51654880
24	NUAK1	1.44981469
25	CDC7	1.44497629
26	PRKCI	1.41496331
27	OXSR1	1.39443094
28	STK3	1.39115772
29	MST4	1.38862239
30	PLK3	1.37590302
31	WNK4	1.32858913
32	PIM1	1.29085193
33	KSR1	1.20672741
34	CDK7	1.19713468
35	NEK2	1.17869463
36	STK16	1.15990443
37	MAP3K8	1.07428882
38	CHEK2	1.00452783
39	ACVR1B	0.99927483
40	PDK2	0.99683332
41	MELK	0.98039076
42	TNIK	0.96061817
43	PLK4	0.89096613
44	CHEK1	0.81450347
45	BRSK1	0.77790537
46	NTRK3	0.76448609
47	TESK2	0.75934541
48	AURKB	0.75429365
49	BMPR1B	0.74382834
50	NTRK2	0.72872386
51	BRSK2	0.69461405
52	MARK3	0.67397759
53	PAK1	0.66731002
54	TIE1	0.64264904
55	VRK1	0.61858137
56	CDK2	0.58894519
57	EIF2AK1	0.58855192
58	STK4	0.54399042
59	ATR	0.52956387
60	MAPKAPK3	0.51919992
61	DMPK	0.50958746
62	WNK1	0.47457599
63	MAP3K5	0.46683097
64	PRKG1	0.45148197
65	RPS6KB2	0.45050686
66	NEK1	0.44983264
67	PKN1	0.44637153
68	AKT2	0.44303298
69	LATS2	0.44280456
70	CDK1	0.43587320
71	LMTK2	0.43104091
72	ATM	0.42798312
73	EIF2AK2	0.42719802
74	AKT3	0.40083625
75	TLK1	0.38674671
76	CSNK1E	0.37418141
77	NEK9	0.35267008
78	CDK8	0.35046693
79	PINK1	0.32223245
80	CSNK1G1	0.30667235
81	PTK2	0.28134076
82	CAMK2A	0.27936126
83	MAP3K4	0.27508783
84	EGFR	0.27289994
85	CSNK2A1	0.27055101
86	LATS1	0.26740075
87	STK38L	0.26531053
88	TGFBR1	0.25604078
89	PRKACB	0.23398077
90	CSNK2A2	0.22919544
91	CSNK1D	0.22239594
92	TNK2	0.22022148
93	PRKACA	0.20030352
94	WNK3	0.17659107
95	GSK3B	0.17105341
96	MAPK1	0.16919393
97	CDK11A	0.16897732
98	PRKCZ	0.16196949
99	BMPR2	0.15905947
100	MAP2K1	0.15521637

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Basal transcription factors_Homo sapiens_hsa03022	5.89381797
2	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	4.17620360
3	Cell cycle_Homo sapiens_hsa04110	3.94144575
4	Mismatch repair_Homo sapiens_hsa03430	3.72648303
5	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.22742911
6	Oocyte meiosis_Homo sapiens_hsa04114	3.09685257
7	Base excision repair_Homo sapiens_hsa03410	2.93340805
8	RNA degradation_Homo sapiens_hsa03018	2.90986415
9	DNA replication_Homo sapiens_hsa03030	2.74347692
10	RNA transport_Homo sapiens_hsa03013	2.59399832
11	Caffeine metabolism_Homo sapiens_hsa00232	2.41185382
12	RNA polymerase_Homo sapiens_hsa03020	2.35213087
13	Nucleotide excision repair_Homo sapiens_hsa03420	2.31514382
14	Homologous recombination_Homo sapiens_hsa03440	2.24480553
15	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.19954653
16	Folate biosynthesis_Homo sapiens_hsa00790	2.10193050
17	Fanconi anemia pathway_Homo sapiens_hsa03460	2.05479009
18	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.98651732
19	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.93647183
20	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.83386532
21	p53 signaling pathway_Homo sapiens_hsa04115	1.65542101
22	Collecting duct acid secretion_Homo sapiens_hsa04966	1.61046109
23	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.61037858
24	mRNA surveillance pathway_Homo sapiens_hsa03015	1.60432560
25	Olfactory transduction_Homo sapiens_hsa04740	1.58916884
26	Regulation of autophagy_Homo sapiens_hsa04140	1.58491108
27	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.53606929
28	Ribosome_Homo sapiens_hsa03010	1.41748468
29	Spliceosome_Homo sapiens_hsa03040	1.22301075
30	Fatty acid elongation_Homo sapiens_hsa00062	1.21765398
31	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.14641844
32	Proteasome_Homo sapiens_hsa03050	1.08348902
33	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.00116848
34	Circadian rhythm_Homo sapiens_hsa04710	0.88757567
35	Phototransduction_Homo sapiens_hsa04744	0.87204067
36	Huntingtons disease_Homo sapiens_hsa05016	0.86217159
37	Thyroid cancer_Homo sapiens_hsa05216	0.85514036
38	Pyrimidine metabolism_Homo sapiens_hsa00240	0.85267434
39	Purine metabolism_Homo sapiens_hsa00230	0.81189887
40	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.77190509
41	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.75582767
42	Protein export_Homo sapiens_hsa03060	0.75119514
43	Non-homologous end-joining_Homo sapiens_hsa03450	0.74239810
44	Steroid biosynthesis_Homo sapiens_hsa00100	0.72539137
45	Gap junction_Homo sapiens_hsa04540	0.65617790
46	Nicotine addiction_Homo sapiens_hsa05033	0.64748123
47	Taste transduction_Homo sapiens_hsa04742	0.62757552
48	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.62007569
49	Viral carcinogenesis_Homo sapiens_hsa05203	0.60883524
50	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.60747620
51	Propanoate metabolism_Homo sapiens_hsa00640	0.60739266
52	ABC transporters_Homo sapiens_hsa02010	0.54356507
53	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.50494977
54	Oxidative phosphorylation_Homo sapiens_hsa00190	0.48188800
55	Vibrio cholerae infection_Homo sapiens_hsa05110	0.47955675
56	Parkinsons disease_Homo sapiens_hsa05012	0.47552292
57	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.47538234
58	Cardiac muscle contraction_Homo sapiens_hsa04260	0.42642981
59	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.40548477
60	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.39231471
61	Herpes simplex infection_Homo sapiens_hsa05168	0.38164515
62	Bile secretion_Homo sapiens_hsa04976	0.37135716
63	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.36649455
64	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.36331646
65	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.34710128
66	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.34654484
67	Pyruvate metabolism_Homo sapiens_hsa00620	0.33231384
68	Long-term depression_Homo sapiens_hsa04730	0.32854895
69	HTLV-I infection_Homo sapiens_hsa05166	0.29222633
70	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.26061773
71	Morphine addiction_Homo sapiens_hsa05032	0.25626202
72	GABAergic synapse_Homo sapiens_hsa04727	0.23415853
73	Hippo signaling pathway_Homo sapiens_hsa04390	0.22978037
74	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.22790608
75	Metabolic pathways_Homo sapiens_hsa01100	0.22183976
76	Serotonergic synapse_Homo sapiens_hsa04726	0.21703164
77	Arginine and proline metabolism_Homo sapiens_hsa00330	0.20623449
78	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.19715822
79	Tight junction_Homo sapiens_hsa04530	0.18883443
80	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.18541129
81	MicroRNAs in cancer_Homo sapiens_hsa05206	0.18212977
82	Wnt signaling pathway_Homo sapiens_hsa04310	0.16546042
83	Sulfur metabolism_Homo sapiens_hsa00920	0.16536258
84	FoxO signaling pathway_Homo sapiens_hsa04068	0.15213759
85	Small cell lung cancer_Homo sapiens_hsa05222	0.15076981
86	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.14893646
87	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.14851894
88	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.14370117
89	Adherens junction_Homo sapiens_hsa04520	0.13373072
90	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.12151567
91	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.11516503
92	Selenocompound metabolism_Homo sapiens_hsa00450	0.08972998
93	mTOR signaling pathway_Homo sapiens_hsa04150	0.08584864
94	Linoleic acid metabolism_Homo sapiens_hsa00591	0.07637049
95	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.07561145
96	Ether lipid metabolism_Homo sapiens_hsa00565	0.07335800
97	Phagosome_Homo sapiens_hsa04145	0.07186072
98	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.06602487
99	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.05297746
100	Protein digestion and absorption_Homo sapiens_hsa04974	0.04882207

DPPA3P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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