DPPA4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a nuclear factor that is involved in the maintenance of pluripotency in stem cells and essential for embryogenesis. The encoded protein has a scaffold-attachment factor A/B, acinus and PIAS (SAP) domain that binds DNA and is thought to modify chromatin. Mice with a homozygous knockout of the orthologous gene die during late embryonic development or within hours after birth. Knockout embryos are normal in size at embryonic day 18.5 but exhibit skeletal and lung tissue abnormalities. This gene, when mutated, is highly expressed in embryonal carcinomas, pluripotent germ cell tumors, and other cancers and is thought to play an important role in tumor progression. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1purine nucleobase biosynthetic process (GO:0009113)5.68287744
2mitotic metaphase plate congression (GO:0007080)5.61253682
3nucleobase biosynthetic process (GO:0046112)5.34313821
4ribosome assembly (GO:0042255)5.28497237
5ribosome biogenesis (GO:0042254)4.83808259
6pre-miRNA processing (GO:0031054)4.82667420
7negative regulation of DNA-dependent DNA replication (GO:2000104)4.82119495
8DNA replication checkpoint (GO:0000076)4.73285025
9establishment of integrated proviral latency (GO:0075713)4.63728072
10regulation of histone H3-K9 methylation (GO:0051570)4.53178444
11metaphase plate congression (GO:0051310)4.51800475
12negative regulation of translation, ncRNA-mediated (GO:0040033)4.44697935
13regulation of translation, ncRNA-mediated (GO:0045974)4.44697935
14negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.44697935
15regulation of spindle organization (GO:0090224)4.41127251
16negative regulation of telomerase activity (GO:0051974)4.32059384
17formation of translation preinitiation complex (GO:0001731)4.24716616
18regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.19422777
19regulation of mitotic spindle checkpoint (GO:1903504)4.19422777
20DNA replication initiation (GO:0006270)4.17868851
21anterior/posterior axis specification, embryo (GO:0008595)4.17567442
22rRNA modification (GO:0000154)4.13530168
23folic acid metabolic process (GO:0046655)4.10488722
24maturation of SSU-rRNA (GO:0030490)4.10007203
25protein localization to kinetochore (GO:0034501)4.03109161
26L-serine metabolic process (GO:0006563)4.02348080
27regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.98583274
28regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.97939006
29regulation of DNA endoreduplication (GO:0032875)3.97711006
30ribonucleoprotein complex biogenesis (GO:0022613)3.97463214
31protein K6-linked ubiquitination (GO:0085020)3.91044384
32nuclear pore organization (GO:0006999)3.88092114
33branching involved in labyrinthine layer morphogenesis (GO:0060670)3.87975541
34mitotic nuclear envelope disassembly (GO:0007077)3.86733397
35heterochromatin organization (GO:0070828)3.84390843
36termination of RNA polymerase III transcription (GO:0006386)3.82778115
37transcription elongation from RNA polymerase III promoter (GO:0006385)3.82778115
38regulation of mitotic spindle organization (GO:0060236)3.82719063
39CENP-A containing nucleosome assembly (GO:0034080)3.80346378
40chromatin remodeling at centromere (GO:0031055)3.80343906
41transcription from RNA polymerase I promoter (GO:0006360)3.79528462
42termination of RNA polymerase I transcription (GO:0006363)3.78190377
43transcription elongation from RNA polymerase I promoter (GO:0006362)3.77754485
44positive regulation of chromosome segregation (GO:0051984)3.74013753
45DNA replication-dependent nucleosome assembly (GO:0006335)3.73002323
46DNA replication-dependent nucleosome organization (GO:0034723)3.73002323
47somatic hypermutation of immunoglobulin genes (GO:0016446)3.72033203
48somatic diversification of immune receptors via somatic mutation (GO:0002566)3.72033203
49establishment of chromosome localization (GO:0051303)3.71254957
50proteasome assembly (GO:0043248)3.69498691
51regulation of nuclear cell cycle DNA replication (GO:0033262)3.66217708
52DNA strand elongation involved in DNA replication (GO:0006271)3.62472827
53rRNA processing (GO:0006364)3.60133842
54nuclear envelope disassembly (GO:0051081)3.59843168
55membrane disassembly (GO:0030397)3.59843168
56protein localization to chromosome, centromeric region (GO:0071459)3.59705287
57spliceosomal snRNP assembly (GO:0000387)3.56464199
58transcription initiation from RNA polymerase I promoter (GO:0006361)3.56451533
59DNA replication-independent nucleosome assembly (GO:0006336)3.56369819
60DNA replication-independent nucleosome organization (GO:0034724)3.56369819
61regulation of gene silencing by RNA (GO:0060966)3.55686088
62regulation of posttranscriptional gene silencing (GO:0060147)3.55686088
63regulation of gene silencing by miRNA (GO:0060964)3.55686088
647-methylguanosine mRNA capping (GO:0006370)3.55208022
65spindle checkpoint (GO:0031577)3.54865593
66IMP biosynthetic process (GO:0006188)3.53903394
67protein complex localization (GO:0031503)3.51418073
68rRNA metabolic process (GO:0016072)3.50119187
69maturation of 5.8S rRNA (GO:0000460)3.49938002
70kinetochore assembly (GO:0051382)3.49485099
71DNA double-strand break processing (GO:0000729)3.48342495
72DNA deamination (GO:0045006)3.47980801
73attachment of spindle microtubules to kinetochore (GO:0008608)3.47973063
74histone exchange (GO:0043486)3.47916303
75anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.47017977
76RNA capping (GO:0036260)3.46511406
777-methylguanosine RNA capping (GO:0009452)3.46511406
78regulation of gene silencing (GO:0060968)3.44849703
79DNA strand elongation (GO:0022616)3.43555036
80telomere maintenance via telomerase (GO:0007004)3.42813714
81negative regulation of chromosome segregation (GO:0051985)3.41990126
82mitotic spindle checkpoint (GO:0071174)3.41324779
83nuclear pore complex assembly (GO:0051292)3.41285203
84regulation of chromosome segregation (GO:0051983)3.40920982
85somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.40515109
86isotype switching (GO:0045190)3.40515109
87somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.40515109
88regulation of cell fate specification (GO:0042659)3.38071074
89negative regulation of mitotic sister chromatid separation (GO:2000816)3.37643314
90negative regulation of mitotic sister chromatid segregation (GO:0033048)3.37643314
91negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.37643314
92negative regulation of sister chromatid segregation (GO:0033046)3.37643314
93ribosomal large subunit biogenesis (GO:0042273)3.37606975
94negative regulation of histone methylation (GO:0031061)3.35672182
95kinetochore organization (GO:0051383)3.34028542
96somatic recombination of immunoglobulin gene segments (GO:0016447)3.33991221
97regulation of double-strand break repair via homologous recombination (GO:0010569)3.33665302
98regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.32615163
99establishment of viral latency (GO:0019043)3.32207219
100positive regulation of SMAD protein import into nucleus (GO:0060391)3.31845497
101mitotic spindle assembly checkpoint (GO:0007094)3.31146734
102positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.29955397
103mitotic sister chromatid segregation (GO:0000070)3.29055672
104blastocyst development (GO:0001824)3.27730826
105negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.27442669
106spindle assembly checkpoint (GO:0071173)3.27122007
107regulation of mitotic metaphase/anaphase transition (GO:0030071)3.25681224
108regulation of helicase activity (GO:0051095)3.25362114
109regulation of telomere maintenance via telomerase (GO:0032210)3.24311474
110telomere maintenance via semi-conservative replication (GO:0032201)3.23646754
111regulation of translation in response to stress (GO:0043555)3.23568380
112transcription-coupled nucleotide-excision repair (GO:0006283)3.21754868
113rRNA methylation (GO:0031167)3.21035018
114establishment of protein localization to mitochondrial membrane (GO:0090151)3.19851881
115spindle assembly involved in mitosis (GO:0090307)3.19455143
116regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.18070773
117negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.17097165
118somatic diversification of immune receptors via germline recombination within a single locus (GO:0003.16691024
119somatic cell DNA recombination (GO:0016444)3.16691024
120cell fate commitment involved in formation of primary germ layer (GO:0060795)3.14201278
121synapsis (GO:0007129)3.11092553
122regulation of sister chromatid segregation (GO:0033045)3.10500336
123regulation of mitotic sister chromatid separation (GO:0010965)3.10500336
124regulation of mitotic sister chromatid segregation (GO:0033047)3.10500336
125regulation of DNA methylation (GO:0044030)3.10028245
126ATP-dependent chromatin remodeling (GO:0043044)3.09923746
127negative regulation of gene silencing (GO:0060969)3.09401046
128positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.09293865
129regulation of centrosome cycle (GO:0046605)3.07186361
130inner cell mass cell proliferation (GO:0001833)3.07158232
131pseudouridine synthesis (GO:0001522)3.05815549
132DNA unwinding involved in DNA replication (GO:0006268)3.04188727
133somatic diversification of immunoglobulins (GO:0016445)3.02972554
134DNA-templated transcription, elongation (GO:0006354)3.01824777
135telomere maintenance via recombination (GO:0000722)3.01564394
136transcription elongation from RNA polymerase II promoter (GO:0006368)3.00679928
137regulation of telomerase activity (GO:0051972)2.99962474
138cell cycle G1/S phase transition (GO:0044843)2.99232494
139G1/S transition of mitotic cell cycle (GO:0000082)2.99232494
140IMP metabolic process (GO:0046040)2.98810508
141synaptonemal complex assembly (GO:0007130)2.97938992
142somatic diversification of immune receptors (GO:0002200)2.95730337
143regulation of mesoderm development (GO:2000380)2.94746622
144exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.94397842
145ncRNA catabolic process (GO:0034661)2.94271786
146regulation of centriole replication (GO:0046599)2.92478693
147negative regulation of DNA recombination (GO:0045910)2.92051384
148negative regulation of mitosis (GO:0045839)2.85042361
149DNA strand renaturation (GO:0000733)2.83382471
150response to X-ray (GO:0010165)2.83345697
151chromatin assembly or disassembly (GO:0006333)2.83077514
152regulation of cell fate commitment (GO:0010453)2.82326597
153telomere maintenance via telomere lengthening (GO:0010833)2.81443517
154mitotic G2/M transition checkpoint (GO:0044818)2.81437691
155single strand break repair (GO:0000012)2.81046434
156replication fork processing (GO:0031297)2.80768236

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.14899940
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.20692403
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.20399292
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.84255296
5MYC_19079543_ChIP-ChIP_MESCs_Mouse3.29854775
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.25613168
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.23120370
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.02754311
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.02515306
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.92004724
11MYC_19030024_ChIP-ChIP_MESCs_Mouse2.89668565
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.87117456
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.85261128
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.82521041
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.80794542
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.78254117
17* POU5F1_16153702_ChIP-ChIP_HESCs_Human2.73790199
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.65095644
19* SOX2_16153702_ChIP-ChIP_HESCs_Human2.39123045
20* NANOG_18555785_ChIP-Seq_MESCs_Mouse2.38083299
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.36802070
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.35695015
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.35617363
24* NANOG_16153702_ChIP-ChIP_HESCs_Human2.27275563
25AR_21909140_ChIP-Seq_LNCAP_Human2.24450562
26POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.20149483
27POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.19678721
28XRN2_22483619_ChIP-Seq_HELA_Human2.15783463
29VDR_23849224_ChIP-Seq_CD4+_Human2.15294442
30KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.13636534
31SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.12000035
32KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.11117782
33KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.11117782
34KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.11117782
35* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.04629955
36HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.04208207
37MYCN_18555785_ChIP-Seq_MESCs_Mouse2.01664868
38* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.01230034
39ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.99404633
40EWS_26573619_Chip-Seq_HEK293_Human1.88789684
41NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.86176062
42MYC_18940864_ChIP-ChIP_HL60_Human1.84285031
43YY1_21170310_ChIP-Seq_MESCs_Mouse1.81919469
44NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.81623611
45ZNF274_21170338_ChIP-Seq_K562_Hela1.79238863
46GABP_19822575_ChIP-Seq_HepG2_Human1.78081695
47HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.78062979
48FUS_26573619_Chip-Seq_HEK293_Human1.75605908
49DCP1A_22483619_ChIP-Seq_HELA_Human1.75095129
50NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.74704616
51SALL1_21062744_ChIP-ChIP_HESCs_Human1.73391841
52FOXP3_21729870_ChIP-Seq_TREG_Human1.72914924
53STAT3_1855785_ChIP-Seq_MESCs_Mouse1.70921119
54THAP11_20581084_ChIP-Seq_MESCs_Mouse1.70625073
55IRF1_19129219_ChIP-ChIP_H3396_Human1.69795300
56CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.69718818
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.67900936
58E2F1_21310950_ChIP-Seq_MCF-7_Human1.67698952
59YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.60278001
60TTF2_22483619_ChIP-Seq_HELA_Human1.60204986
61PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58950174
62GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.55721469
63TCF3_18692474_ChIP-Seq_MEFs_Mouse1.53152968
64VDR_22108803_ChIP-Seq_LS180_Human1.50606555
65ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.47275314
66KDM5A_27292631_Chip-Seq_BREAST_Human1.45451162
67MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.43441665
68SOX2_18555785_ChIP-Seq_MESCs_Mouse1.42910488
69KLF4_18555785_ChIP-Seq_MESCs_Mouse1.39375983
70NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.36821187
71NOTCH1_21737748_ChIP-Seq_TLL_Human1.33866279
72FLI1_27457419_Chip-Seq_LIVER_Mouse1.32773885
73ELK1_19687146_ChIP-ChIP_HELA_Human1.31629293
74ZFX_18555785_ChIP-Seq_MESCs_Mouse1.30704289
75FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.30415094
76EGR1_19374776_ChIP-ChIP_THP-1_Human1.29713272
77TCF3_18692474_ChIP-Seq_MESCs_Mouse1.28916390
78KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.27063175
79P300_19829295_ChIP-Seq_ESCs_Human1.25185148
80TP63_19390658_ChIP-ChIP_HaCaT_Human1.21147687
81CIITA_25753668_ChIP-Seq_RAJI_Human1.19676070
82ZNF263_19887448_ChIP-Seq_K562_Human1.19632932
83ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.18444385
84SRF_21415370_ChIP-Seq_HL-1_Mouse1.17013021
85NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.16787413
86* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.16700794
87PADI4_21655091_ChIP-ChIP_MCF-7_Human1.14435269
88NANOG_21062744_ChIP-ChIP_HESCs_Human1.14207759
89* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.14098705
90SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.13933335
91ELF1_17652178_ChIP-ChIP_JURKAT_Human1.13407350
92* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.13103972
93TBX3_20139965_ChIP-Seq_ESCs_Mouse1.10739191
94* GATA1_26923725_Chip-Seq_HPCs_Mouse1.09765487
95TBX3_20139965_ChIP-Seq_MESCs_Mouse1.09112338
96ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.08856305
97OCT4_18692474_ChIP-Seq_MEFs_Mouse1.07642556
98HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.07326493
99PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.05860806
100* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.04648315
101* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.02646706
102GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02607704
103SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.02449376
104CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.01982315
105* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.01305310
106TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.01115202
107SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.00967638
108CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.00452839
109ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.99722395
110DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.99571680
111GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99037269
112ELK1_22589737_ChIP-Seq_MCF10A_Human0.97257860
113CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.96923663
114HOXB4_20404135_ChIP-ChIP_EML_Mouse0.96480403
115* SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.96044103
116TFEB_21752829_ChIP-Seq_HELA_Human0.95569699
117KAP1_27257070_Chip-Seq_ESCs_Mouse0.95393381
118BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.95255200
119TAF15_26573619_Chip-Seq_HEK293_Human0.94163924
120SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.92900761
121E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92062288
122SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.91285902
123* NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.89871643
124* NANOG_18692474_ChIP-Seq_MESCs_Mouse0.89858763
125TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.87033772
126STAT6_21828071_ChIP-Seq_BEAS2B_Human0.85132545
127PCGF2_27294783_Chip-Seq_ESCs_Mouse0.85023910
128TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84832954
129POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.84832954
130NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.84384384
131LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81374258

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.49645839
2MP0003111_abnormal_nucleus_morphology5.15813331
3MP0004957_abnormal_blastocyst_morpholog4.84694406
4MP0010094_abnormal_chromosome_stability4.45998546
5MP0003077_abnormal_cell_cycle4.07199688
6MP0008057_abnormal_DNA_replication3.84802499
7MP0002254_reproductive_system_inflammat3.65152898
8MP0008058_abnormal_DNA_repair3.62789014
9MP0003123_paternal_imprinting2.85222143
10* MP0003718_maternal_effect2.82583986
11MP0008932_abnormal_embryonic_tissue2.72036318
12MP0001730_embryonic_growth_arrest2.71748832
13MP0008877_abnormal_DNA_methylation2.67752826
14MP0003786_premature_aging2.61136593
15MP0008007_abnormal_cellular_replicative2.57043203
16MP0001188_hyperpigmentation2.42245248
17MP0000350_abnormal_cell_proliferation2.32023148
18MP0001485_abnormal_pinna_reflex2.30064311
19MP0003806_abnormal_nucleotide_metabolis2.15561290
20MP0005380_embryogenesis_phenotype2.06853466
21MP0001672_abnormal_embryogenesis/_devel2.06853466
22MP0010307_abnormal_tumor_latency1.97234720
23MP0008260_abnormal_autophagy1.92328105
24MP0000049_abnormal_middle_ear1.87793954
25MP0002653_abnormal_ependyma_morphology1.83218609
26MP0003941_abnormal_skin_development1.81665155
27MP0001697_abnormal_embryo_size1.81217647
28MP0002210_abnormal_sex_determination1.74674535
29MP0003984_embryonic_growth_retardation1.73706577
30MP0002085_abnormal_embryonic_tissue1.73197367
31MP0002088_abnormal_embryonic_growth/wei1.69912454
32MP0002080_prenatal_lethality1.67204576
33MP0006292_abnormal_olfactory_placode1.64918298
34MP0003315_abnormal_perineum_morphology1.62515414
35MP0002084_abnormal_developmental_patter1.57280753
36MP0010352_gastrointestinal_tract_polyps1.56084899
37MP0001145_abnormal_male_reproductive1.54354145
38MP0003136_yellow_coat_color1.49760529
39MP0002086_abnormal_extraembryonic_tissu1.47723700
40MP0003567_abnormal_fetal_cardiomyocyte1.45566607
41MP0003787_abnormal_imprinting1.45375690
42MP0001929_abnormal_gametogenesis1.43735567
43MP0000653_abnormal_sex_gland1.34927925
44MP0002697_abnormal_eye_size1.29733450
45MP0002938_white_spotting1.27939382
46MP0000313_abnormal_cell_death1.26459529
47MP0001293_anophthalmia1.25829047
48MP0005377_hearing/vestibular/ear_phenot1.23411692
49MP0003878_abnormal_ear_physiology1.23411692
50MP0003119_abnormal_digestive_system1.23334447
51MP0009840_abnormal_foam_cell1.19584497
52MP0002751_abnormal_autonomic_nervous1.19532228
53MP0006072_abnormal_retinal_apoptosis1.19392937
54MP0001661_extended_life_span1.16132206
55MP0004133_heterotaxia1.15799495
56* MP0004197_abnormal_fetal_growth/weight/1.13370537
57MP0002160_abnormal_reproductive_system1.11749328
58MP0000579_abnormal_nail_morphology1.11353559
59MP0002102_abnormal_ear_morphology1.08209218
60MP0002396_abnormal_hematopoietic_system1.07202959
61MP0000631_abnormal_neuroendocrine_gland1.03496946
62MP0002019_abnormal_tumor_incidence1.02614012
63MP0009672_abnormal_birth_weight1.01586301
64MP0008789_abnormal_olfactory_epithelium1.01159640
65MP0005389_reproductive_system_phenotype0.99397823
66* MP0005395_other_phenotype0.98895939
67MP0003221_abnormal_cardiomyocyte_apopto0.98710868
68MP0003890_abnormal_embryonic-extraembry0.95816757
69MP0001119_abnormal_female_reproductive0.94801073
70MP0000358_abnormal_cell_content/0.93933845
71MP0000516_abnormal_urinary_system0.93308696
72MP0005367_renal/urinary_system_phenotyp0.93308696
73MP0000750_abnormal_muscle_regeneration0.93219799
74MP0003937_abnormal_limbs/digits/tail_de0.92592430
75MP0005076_abnormal_cell_differentiation0.91413446
76MP0001299_abnormal_eye_distance/0.90996679
77MP0003121_genomic_imprinting0.89927311
78MP0003698_abnormal_male_reproductive0.89570942
79MP0005621_abnormal_cell_physiology0.89176320
80MP0002233_abnormal_nose_morphology0.88797007
81MP0005384_cellular_phenotype0.88748189
82MP0003186_abnormal_redox_activity0.88407940
83MP0003283_abnormal_digestive_organ0.88302119
84MP0009333_abnormal_splenocyte_physiolog0.88056307
85MP0000490_abnormal_crypts_of0.87803944
86MP0008770_decreased_survivor_rate0.85127765
87MP0009250_abnormal_appendicular_skeleto0.84991402
88MP0009697_abnormal_copulation0.84617604
89MP0009703_decreased_birth_body0.84400861
90MP0009384_cardiac_valve_regurgitation0.83409893
91MP0003938_abnormal_ear_development0.83204307
92MP0005499_abnormal_olfactory_system0.81860738
93MP0005394_taste/olfaction_phenotype0.81860738
94MP0005451_abnormal_body_composition0.80864106
95MP0004185_abnormal_adipocyte_glucose0.79812170
96MP0008995_early_reproductive_senescence0.79223933
97MP0002736_abnormal_nociception_after0.79189477
98MP0003936_abnormal_reproductive_system0.79059560
99MP0006035_abnormal_mitochondrial_morpho0.78174618
100MP0002111_abnormal_tail_morphology0.77897927
101* MP0002161_abnormal_fertility/fecundity0.77147300
102MP0001542_abnormal_bone_strength0.76632728
103* MP0003699_abnormal_female_reproductive0.76208365
104MP0001849_ear_inflammation0.74018610
105MP0001286_abnormal_eye_development0.72916823
106MP0010030_abnormal_orbit_morphology0.72022213
107MP0003755_abnormal_palate_morphology0.68708856
108MP0000627_abnormal_mammary_gland0.67447230
109MP0002092_abnormal_eye_morphology0.66367768
110MP0002090_abnormal_vision0.65148415
111MP0001919_abnormal_reproductive_system0.64937492
112MP0005266_abnormal_metabolism0.64319384
113MP0000428_abnormal_craniofacial_morphol0.62179019
114MP0005397_hematopoietic_system_phenotyp0.62160374
115MP0001545_abnormal_hematopoietic_system0.62160374
116* MP0001177_atelectasis0.61776460
117MP0002127_abnormal_cardiovascular_syste0.61753071
118MP0004084_abnormal_cardiac_muscle0.61358975
119MP0002116_abnormal_craniofacial_bone0.61254240
120MP0009053_abnormal_anal_canal0.61130069
121MP0003646_muscle_fatigue0.57740298
122MP0008872_abnormal_physiological_respon0.57276375
123MP0002269_muscular_atrophy0.57263126
124* MP0002081_perinatal_lethality0.56545208
125MP0003122_maternal_imprinting0.56122782
126MP0006036_abnormal_mitochondrial_physio0.55423913
127MP0003861_abnormal_nervous_system0.55112641
128MP0000432_abnormal_head_morphology0.54585960
129MP0004264_abnormal_extraembryonic_tissu0.54116732
130MP0000537_abnormal_urethra_morphology0.52273461
131MP0002132_abnormal_respiratory_system0.51872700

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)6.26657974
2Breast hypoplasia (HP:0003187)5.82488400
3Carpal bone hypoplasia (HP:0001498)4.89195768
4Impulsivity (HP:0100710)4.50212915
5Abnormality of the labia minora (HP:0012880)4.23233371
6Cerebral hypomyelination (HP:0006808)4.15154861
7Patellar aplasia (HP:0006443)3.97333215
8Rough bone trabeculation (HP:0100670)3.88673152
9Absent radius (HP:0003974)3.85198860
10Aplasia/Hypoplasia of the patella (HP:0006498)3.83951555
11Hyperglycinemia (HP:0002154)3.68707583
12Aplasia involving forearm bones (HP:0009822)3.61989310
13Absent forearm bone (HP:0003953)3.61989310
14Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.59025245
15Abnormality of the anterior horn cell (HP:0006802)3.58317895
16Degeneration of anterior horn cells (HP:0002398)3.58317895
17Septo-optic dysplasia (HP:0100842)3.43626083
18Ependymoma (HP:0002888)3.40861090
19Chromosomal breakage induced by crosslinking agents (HP:0003221)3.36146618
20Chromsome breakage (HP:0040012)3.28458116
21Oral leukoplakia (HP:0002745)3.19638664
22Ureteral duplication (HP:0000073)3.07928999
23Short hallux (HP:0010109)3.07011504
24Hyperglycinuria (HP:0003108)3.04627336
25Abnormality of the renal collecting system (HP:0004742)3.02861183
26Meckel diverticulum (HP:0002245)3.02784463
27Premature ovarian failure (HP:0008209)2.95006089
28Abnormality of the preputium (HP:0100587)2.91119060
29Aplasia/Hypoplasia of the hallux (HP:0008362)2.91062687
30Supernumerary spleens (HP:0009799)2.86935717
31Abnormal trabecular bone morphology (HP:0100671)2.86212690
32Nephroblastoma (Wilms tumor) (HP:0002667)2.84109442
33Abnormality of the ileum (HP:0001549)2.80791462
34Horseshoe kidney (HP:0000085)2.79121752
35Multiple enchondromatosis (HP:0005701)2.73022204
36Choanal stenosis (HP:0000452)2.71149274
37Absent thumb (HP:0009777)2.69433137
38Abnormality of chromosome stability (HP:0003220)2.69400098
39CNS hypomyelination (HP:0003429)2.68466311
40Selective tooth agenesis (HP:0001592)2.68332306
41Aplasia/Hypoplasia involving the musculature (HP:0001460)2.67272035
42Secondary amenorrhea (HP:0000869)2.66413346
43Aplasia/hypoplasia of the humerus (HP:0006507)2.66264687
44Embryonal renal neoplasm (HP:0011794)2.65443728
45Pendular nystagmus (HP:0012043)2.60181327
46Aplasia/Hypoplasia of the uvula (HP:0010293)2.57893588
47Bilateral microphthalmos (HP:0007633)2.54651261
48Progressive muscle weakness (HP:0003323)2.54532030
49Colon cancer (HP:0003003)2.54180027
50Abnormal lung lobation (HP:0002101)2.51479967
51Breast aplasia (HP:0100783)2.49576713
52Intestinal fistula (HP:0100819)2.48434175
53Medulloblastoma (HP:0002885)2.48431801
54Abolished electroretinogram (ERG) (HP:0000550)2.46858027
55Abnormality of homocysteine metabolism (HP:0010919)2.46000854
56Homocystinuria (HP:0002156)2.46000854
57Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.45946998
58Short 1st metacarpal (HP:0010034)2.42533770
59Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.42533770
60Stenosis of the external auditory canal (HP:0000402)2.42461575
61Neoplasm of the pancreas (HP:0002894)2.40407188
62Agnosia (HP:0010524)2.38864442
63Trismus (HP:0000211)2.38198451
64Maternal diabetes (HP:0009800)2.36864671
65Facial hemangioma (HP:0000329)2.34469479
66Abnormality of serine family amino acid metabolism (HP:0010894)2.34387790
67Abnormality of glycine metabolism (HP:0010895)2.34387790
68Hepatoblastoma (HP:0002884)2.34194594
69Aplasia/Hypoplasia of the breasts (HP:0010311)2.34145918
70Reticulocytopenia (HP:0001896)2.32242163
71Bone marrow hypocellularity (HP:0005528)2.31647997
72Vaginal fistula (HP:0004320)2.29973230
73Abnormal spermatogenesis (HP:0008669)2.29736639
74Spinal muscular atrophy (HP:0007269)2.28472809
75Small intestinal stenosis (HP:0012848)2.26781782
76Duodenal stenosis (HP:0100867)2.26781782
77Rhabdomyosarcoma (HP:0002859)2.26727814
78Shawl scrotum (HP:0000049)2.25733587
79Abnormality of the umbilical cord (HP:0010881)2.24698917
80Glioma (HP:0009733)2.24368212
81Abnormality of the parathyroid morphology (HP:0011766)2.22663444
82Abnormality of cochlea (HP:0000375)2.21333497
83Atrophy/Degeneration involving motor neurons (HP:0007373)2.20920998
84Microretrognathia (HP:0000308)2.18366843
85Oligodactyly (HP:0012165)2.18302428
86Neoplasm of the adrenal cortex (HP:0100641)2.16768827
87Premature graying of hair (HP:0002216)2.16095472
88Oligodactyly (hands) (HP:0001180)2.15546140
89Abnormality of the carotid arteries (HP:0005344)2.13549710
90Abnormality of the astrocytes (HP:0100707)2.09954859
91Astrocytoma (HP:0009592)2.09954859
92Abnormality of the 1st metacarpal (HP:0010009)2.09794245
93Sparse eyelashes (HP:0000653)2.09070823
94Tracheoesophageal fistula (HP:0002575)2.08979444
95Death in infancy (HP:0001522)2.08527584
96Areflexia of lower limbs (HP:0002522)2.08293727
97Short humerus (HP:0005792)2.06705434
98Methylmalonic acidemia (HP:0002912)2.06667927
99Megaloblastic anemia (HP:0001889)2.05925176
100Abnormality of serum amino acid levels (HP:0003112)2.05009911
101Hypoplasia of the pons (HP:0012110)2.02653174
102Short thumb (HP:0009778)2.01408532
103Cleft eyelid (HP:0000625)2.00636165
104Duplicated collecting system (HP:0000081)1.98700658
105Triphalangeal thumb (HP:0001199)1.98219874
106Personality changes (HP:0000751)1.97889198
107Abnormality of DNA repair (HP:0003254)1.97224743
108Absent septum pellucidum (HP:0001331)1.97199594
109Macrocytic anemia (HP:0001972)1.96403858
110Chronic bronchitis (HP:0004469)1.96291755
111Cellular immunodeficiency (HP:0005374)1.95263146
112Rectovaginal fistula (HP:0000143)1.94199742
113Rectal fistula (HP:0100590)1.94199742
114Sloping forehead (HP:0000340)1.94056709
115Fused cervical vertebrae (HP:0002949)1.94006836
116Abnormality of the septum pellucidum (HP:0007375)1.93046906
117Atresia of the external auditory canal (HP:0000413)1.92357615
118Abnormality of the duodenum (HP:0002246)1.90886139
119Spastic diplegia (HP:0001264)1.89552616
120Hypoplasia of the radius (HP:0002984)1.89471779
121Abnormality of cells of the erythroid lineage (HP:0012130)1.89350339
122Abnormality of the salivary glands (HP:0010286)1.88646916
123Myelodysplasia (HP:0002863)1.86732516
124Hypoplasia of the capital femoral epiphysis (HP:0003090)1.86597825
125Duplication of thumb phalanx (HP:0009942)1.85793201
126Abnormality of the pons (HP:0007361)1.85648490
127Anal stenosis (HP:0002025)1.85465587
128Neoplasm of the oral cavity (HP:0100649)1.85447394
129Clubbing of toes (HP:0100760)1.84815490
130Optic nerve coloboma (HP:0000588)1.84716148
131Aplasia/Hypoplasia of the sternum (HP:0006714)1.84350183
132Entropion (HP:0000621)1.83514932
133Abnormal number of incisors (HP:0011064)1.82646545
134Ectopic kidney (HP:0000086)1.82329178
135Preaxial foot polydactyly (HP:0001841)1.80419697
136Squamous cell carcinoma (HP:0002860)1.80121717
137Azoospermia (HP:0000027)1.79910803
138Uterine neoplasm (HP:0010784)1.78713330
139Aplasia/Hypoplasia of the earlobes (HP:0009906)1.78058354
140Renal agenesis (HP:0000104)1.78052855
141Neoplasm of the colon (HP:0100273)1.77996954
142Facial cleft (HP:0002006)1.77975417
143Osteomalacia (HP:0002749)1.74885271
144Malignant gastrointestinal tract tumors (HP:0006749)1.74753907
145Gastrointestinal carcinoma (HP:0002672)1.74753907
146Genetic anticipation (HP:0003743)1.74440194
147Abnormal hair whorl (HP:0010721)1.74410213
148Esophageal atresia (HP:0002032)1.74181000
149Methylmalonic aciduria (HP:0012120)1.72185258
150Protruding tongue (HP:0010808)1.71799974

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.47669913
2WEE15.09473082
3EIF2AK13.10670978
4TAF13.05035002
5SRPK12.91726712
6EPHA22.86501266
7NEK22.85139537
8TNIK2.81184300
9CDC72.77958283
10TTK2.75919605
11PLK42.75012961
12TSSK62.70000140
13VRK22.64748182
14NEK12.45283675
15AKT32.43119858
16PNCK2.37623952
17PLK12.30203699
18BRSK22.27182671
19ACVR1B2.14293333
20NUAK12.11471425
21PLK32.06345895
22STK162.04228471
23EIF2AK31.97382148
24MKNK21.92519771
25BMPR1B1.84185204
26NME21.76400895
27DYRK31.70330374
28MKNK11.65584404
29CDK191.64486340
30CHEK21.63084271
31STK38L1.59373337
32AURKB1.50620064
33CDK71.45943847
34BRSK11.42643149
35AURKA1.42210547
36ZAK1.41200634
37LATS21.37675682
38MAP3K101.36904893
39GRK11.35406861
40CDK121.34249651
41TESK21.28443427
42NLK1.26575367
43TRIM281.22614286
44BRAF1.19880582
45ATR1.19668353
46PDK31.19266386
47PDK41.19266386
48CHEK11.19026691
49VRK11.16320550
50ALK1.15821127
51MST41.14126914
52PDK21.09476423
53CDK41.09403546
54RPS6KB21.08196724
55MAP3K81.03989353
56PRKCI0.98549362
57CCNB10.93423217
58RPS6KA40.91864893
59SMG10.91857211
60OXSR10.91577592
61FGFR20.87697493
62CDK20.87609112
63EIF2AK20.86887635
64FRK0.84971697
65TGFBR10.84968167
66FGFR10.84714235
67STK30.82731192
68TLK10.81189897
69TIE10.77615579
70ARAF0.76740701
71PINK10.73813631
72ATM0.73390983
73STK40.72537472
74CAMK1D0.71141091
75CSNK2A20.69817496
76CAMK1G0.69804145
77ADRBK20.69796182
78DYRK20.69582871
79PAK10.69402708
80IRAK30.68402622
81MAP3K40.68345445
82PASK0.67124792
83MELK0.64450426
84CDK10.64250688
85CSNK1E0.64182406
86CSNK2A10.62858244
87PIM10.62839269
88CDK90.62786174
89CASK0.61547163
90PAK40.58633277
91FLT30.57272412
92PLK20.55465646
93CSNK1G20.54403260
94INSRR0.52147443
95BRD40.52088027
96BCKDK0.49810716
97PRKCG0.48288964
98NME10.46176300
99LATS10.45559228
100MTOR0.42656313
101RPS6KA50.40530251
102STK100.38318847
103TEC0.36418944
104DYRK1A0.36415269
105NEK60.33818484
106CSNK1G30.32969358
107STK240.32675436
108CSNK1G10.32108659
109PBK0.31511599
110PIM20.31144510
111CDK30.30972437
112MARK30.30759803
113CDK60.29857944
114SGK20.29328233
115WNK30.29117376
116DAPK10.28907907
117MAPKAPK30.28141546
118ABL20.27934381
119SGK2230.27883882
120SGK4940.27883882
121PRKDC0.27175506
122AKT20.26603345
123CSNK1D0.26136262
124STK380.25063020
125MAP3K90.23046437
126MAPK100.21224799
127GSK3B0.21097282
128MAPK140.20188634
129PRKAA10.19972165
130RAF10.17483972
131CSNK1A10.16318981
132CDK80.15321589
133CSNK1A1L0.14372550
134SCYL20.14002325
135ERBB40.12324482

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.80773024
2RNA polymerase_Homo sapiens_hsa030204.53302211
3DNA replication_Homo sapiens_hsa030303.80068687
4Proteasome_Homo sapiens_hsa030503.65666689
5RNA transport_Homo sapiens_hsa030133.65479066
6Vitamin B6 metabolism_Homo sapiens_hsa007503.64424437
7Mismatch repair_Homo sapiens_hsa034303.57889062
8Spliceosome_Homo sapiens_hsa030403.09509256
9Homologous recombination_Homo sapiens_hsa034402.74061744
10Cell cycle_Homo sapiens_hsa041102.70488305
11Pyrimidine metabolism_Homo sapiens_hsa002402.63106098
12Nucleotide excision repair_Homo sapiens_hsa034202.61922628
13Ribosome_Homo sapiens_hsa030102.57120061
14Basal transcription factors_Homo sapiens_hsa030222.50350355
15Base excision repair_Homo sapiens_hsa034102.29215631
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.28913777
17Fanconi anemia pathway_Homo sapiens_hsa034602.25622102
18One carbon pool by folate_Homo sapiens_hsa006702.23392189
19Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.90752612
20mRNA surveillance pathway_Homo sapiens_hsa030151.72425640
21p53 signaling pathway_Homo sapiens_hsa041151.69514422
22RNA degradation_Homo sapiens_hsa030181.68304820
23Purine metabolism_Homo sapiens_hsa002301.61087798
24Folate biosynthesis_Homo sapiens_hsa007901.51930502
25Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.48987148
26Non-homologous end-joining_Homo sapiens_hsa034501.45080862
27Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.39563601
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.39260353
29Regulation of autophagy_Homo sapiens_hsa041401.36754738
30Protein export_Homo sapiens_hsa030601.33634946
31Oocyte meiosis_Homo sapiens_hsa041141.31607891
32Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.26951368
33Pentose phosphate pathway_Homo sapiens_hsa000301.24960311
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.24287399
35Epstein-Barr virus infection_Homo sapiens_hsa051691.23661662
36Steroid biosynthesis_Homo sapiens_hsa001001.16031737
37Pyruvate metabolism_Homo sapiens_hsa006201.09661914
38Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.08353350
39Biosynthesis of amino acids_Homo sapiens_hsa012301.07189913
40Nicotine addiction_Homo sapiens_hsa050331.06122455
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.05946295
42Propanoate metabolism_Homo sapiens_hsa006401.05621326
43Drug metabolism - other enzymes_Homo sapiens_hsa009831.04904506
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.99512760
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.96892237
46Wnt signaling pathway_Homo sapiens_hsa043100.89979414
47Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.88868314
48Parkinsons disease_Homo sapiens_hsa050120.84796040
49Selenocompound metabolism_Homo sapiens_hsa004500.84432693
50Cyanoamino acid metabolism_Homo sapiens_hsa004600.80773119
51Phototransduction_Homo sapiens_hsa047440.80381342
52Glycerophospholipid metabolism_Homo sapiens_hsa005640.79276906
53Fructose and mannose metabolism_Homo sapiens_hsa000510.79237444
54Lysine degradation_Homo sapiens_hsa003100.78227351
55Oxidative phosphorylation_Homo sapiens_hsa001900.76872000
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76127116
572-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.72375012
58Taste transduction_Homo sapiens_hsa047420.67559505
59Vitamin digestion and absorption_Homo sapiens_hsa049770.66496091
60Retinol metabolism_Homo sapiens_hsa008300.64923342
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64594456
62Sulfur relay system_Homo sapiens_hsa041220.63836163
63Glutathione metabolism_Homo sapiens_hsa004800.62710917
64Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61580749
65Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60896356
66Carbon metabolism_Homo sapiens_hsa012000.60017668
67Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.59491261
68Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56861072
69Viral carcinogenesis_Homo sapiens_hsa052030.55591604
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.51622976
71Systemic lupus erythematosus_Homo sapiens_hsa053220.48459156
72Alzheimers disease_Homo sapiens_hsa050100.47621660
73Tryptophan metabolism_Homo sapiens_hsa003800.46774566
74Arginine and proline metabolism_Homo sapiens_hsa003300.45917348
75Herpes simplex infection_Homo sapiens_hsa051680.44771458
76Antigen processing and presentation_Homo sapiens_hsa046120.44250146
77Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44162611
78Adherens junction_Homo sapiens_hsa045200.44053187
79Huntingtons disease_Homo sapiens_hsa050160.42820228
80Hippo signaling pathway_Homo sapiens_hsa043900.40613019
81Metabolic pathways_Homo sapiens_hsa011000.37835886
82Ether lipid metabolism_Homo sapiens_hsa005650.36408678
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35628456
84Melanoma_Homo sapiens_hsa052180.35220238
85Linoleic acid metabolism_Homo sapiens_hsa005910.34954403
86MicroRNAs in cancer_Homo sapiens_hsa052060.34309168
87Cardiac muscle contraction_Homo sapiens_hsa042600.34249418
88Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.33960042
89HTLV-I infection_Homo sapiens_hsa051660.33158497
90Fatty acid elongation_Homo sapiens_hsa000620.32638709
91Serotonergic synapse_Homo sapiens_hsa047260.32543261
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32183972
93mTOR signaling pathway_Homo sapiens_hsa041500.32138092
94Caffeine metabolism_Homo sapiens_hsa002320.30895808
95Arachidonic acid metabolism_Homo sapiens_hsa005900.30635166
96Thyroid cancer_Homo sapiens_hsa052160.29253543
97TGF-beta signaling pathway_Homo sapiens_hsa043500.28709271
98Nitrogen metabolism_Homo sapiens_hsa009100.27578316
99Maturity onset diabetes of the young_Homo sapiens_hsa049500.24561293
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.22606308
101Fat digestion and absorption_Homo sapiens_hsa049750.22529978
102Chemical carcinogenesis_Homo sapiens_hsa052040.22450659
103Tight junction_Homo sapiens_hsa045300.20384185
104Butanoate metabolism_Homo sapiens_hsa006500.19870177
105Galactose metabolism_Homo sapiens_hsa000520.19185621
106Hedgehog signaling pathway_Homo sapiens_hsa043400.19011958
107Peroxisome_Homo sapiens_hsa041460.18896970
108alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.17733848
109Small cell lung cancer_Homo sapiens_hsa052220.17331212
110Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.15328486
111Circadian rhythm_Homo sapiens_hsa047100.14514917
112FoxO signaling pathway_Homo sapiens_hsa040680.13360948
113Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.11723032
114HIF-1 signaling pathway_Homo sapiens_hsa040660.11032230
115Renin-angiotensin system_Homo sapiens_hsa046140.10784108
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.10258907
117Basal cell carcinoma_Homo sapiens_hsa052170.09602790
118Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.04924437
119Glycerolipid metabolism_Homo sapiens_hsa005610.03682119
120Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.03321910
121Prostate cancer_Homo sapiens_hsa052150.03197331
122Notch signaling pathway_Homo sapiens_hsa043300.02942941
123Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.02849615
124Apoptosis_Homo sapiens_hsa042100.02467225
125Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.01826782
126Pathways in cancer_Homo sapiens_hsa052000.01552573
127beta-Alanine metabolism_Homo sapiens_hsa004100.00482694
128Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.00273190
129Alcoholism_Homo sapiens_hsa05034-0.0490827
130Mineral absorption_Homo sapiens_hsa04978-0.0486289
131Colorectal cancer_Homo sapiens_hsa05210-0.0425349
132AMPK signaling pathway_Homo sapiens_hsa04152-0.0424987
133Legionellosis_Homo sapiens_hsa05134-0.0418583
134Pathogenic Escherichia coli infection_Homo sapiens_hsa05130-0.0413622
135Inositol phosphate metabolism_Homo sapiens_hsa00562-0.0399167
136Sphingolipid metabolism_Homo sapiens_hsa00600-0.0260666
137Bladder cancer_Homo sapiens_hsa05219-0.0149943
138Thyroid hormone signaling pathway_Homo sapiens_hsa04919-0.0064310

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