DPPA5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that may function in the control of cell pluripotency and early embryogenesis. Expression of this gene is a specific marker for pluripotent stem cells. Pseudogenes of this gene are located on the short arm of chromosome 10 and the long arm of chromosomes 14 and 19. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of meiosis I (GO:0060631)9.04808687
2regulation of female gonad development (GO:2000194)8.07313230
3piRNA metabolic process (GO:0034587)7.83484159
4meiotic cell cycle (GO:0051321)6.84296455
5DNA methylation involved in gamete generation (GO:0043046)5.94499606
6female gamete generation (GO:0007292)5.91905329
7regulation of acrosome reaction (GO:0060046)5.79489126
8glycine transport (GO:0015816)5.58947741
9regulation of cell maturation (GO:1903429)5.53512944
10retinal cone cell development (GO:0046549)5.48282950
11oocyte development (GO:0048599)5.39799045
12positive regulation of mitotic metaphase/anaphase transition (GO:0045842)5.33458179
13positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)5.33458179
14positive regulation of mitotic sister chromatid separation (GO:1901970)5.33458179
15mitotic metaphase plate congression (GO:0007080)5.27850008
16regulation of histone H3-K9 methylation (GO:0051570)5.25460868
17mitotic chromosome condensation (GO:0007076)5.23183399
18protein localization to chromosome, centromeric region (GO:0071459)5.22375462
19primitive streak formation (GO:0090009)5.22196388
20positive regulation of chromosome segregation (GO:0051984)5.17217220
21male meiosis I (GO:0007141)5.08871065
22multicellular organism reproduction (GO:0032504)5.03966747
23positive regulation of histone H3-K4 methylation (GO:0051571)4.98551030
24positive regulation of gastrulation (GO:2000543)4.91287961
25negative regulation of reproductive process (GO:2000242)4.87425463
26regulation of steroid hormone secretion (GO:2000831)4.75770426
27gene silencing by RNA (GO:0031047)4.71312984
28establishment of chromosome localization (GO:0051303)4.58222347
29protein localization to kinetochore (GO:0034501)4.54904122
30male meiosis (GO:0007140)4.48415455
31synapsis (GO:0007129)4.45754200
32negative regulation of histone methylation (GO:0031061)4.43091977
33regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.42094586
34synaptonemal complex assembly (GO:0007130)4.40223093
35regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.36510463
36centriole replication (GO:0007099)4.29521137
37CENP-A containing nucleosome assembly (GO:0034080)4.24933678
38meiosis I (GO:0007127)4.24533006
39regulation of meiosis (GO:0040020)4.23717721
40metaphase plate congression (GO:0051310)4.23461743
41meiotic nuclear division (GO:0007126)4.09742122
42positive regulation of uterine smooth muscle contraction (GO:0070474)4.07758273
43chromosome organization involved in meiosis (GO:0070192)4.05894241
44protein localization to chromosome (GO:0034502)4.02822867
45synaptonemal complex organization (GO:0070193)3.97699655
46regulation of spindle organization (GO:0090224)3.93653709
47L-amino acid import (GO:0043092)3.92578764
48chromatin remodeling at centromere (GO:0031055)3.86084680
49oogenesis (GO:0048477)3.81269498
50regulation of double-strand break repair via homologous recombination (GO:0010569)3.77713220
51positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.71100425
52meiotic cell cycle process (GO:1903046)3.68122862
53somite rostral/caudal axis specification (GO:0032525)3.64628519
54protein kinase C signaling (GO:0070528)3.64003618
55nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.59869568
56regulation of meiotic cell cycle (GO:0051445)3.55284661
57attachment of spindle microtubules to kinetochore (GO:0008608)3.43843020
58negative regulation of execution phase of apoptosis (GO:1900118)3.41920451
59neuron fate determination (GO:0048664)3.37573048
60histone exchange (GO:0043486)3.35055431
61DNA alkylation (GO:0006305)3.34504957
62DNA methylation (GO:0006306)3.34504957
63DNA replication-independent nucleosome organization (GO:0034724)3.31773275
64DNA replication-independent nucleosome assembly (GO:0006336)3.31773275
65translesion synthesis (GO:0019985)3.31492794
66regulation of spindle checkpoint (GO:0090231)3.29788156
67relaxation of smooth muscle (GO:0044557)3.26800719
68labyrinthine layer development (GO:0060711)3.24980799
69reproduction (GO:0000003)3.24854220
70regulation of uterine smooth muscle contraction (GO:0070472)3.23520424
71positive regulation of humoral immune response (GO:0002922)3.21947479
72negative regulation of cAMP-mediated signaling (GO:0043951)3.17976738
73fertilization (GO:0009566)3.13943245
74positive regulation of reproductive process (GO:2000243)3.13344134
75DNA damage induced protein phosphorylation (GO:0006975)3.10782042
76positive regulation of histone methylation (GO:0031062)3.10219130
77pyrimidine-containing compound transmembrane transport (GO:0072531)3.10169977
78regulation of histone methylation (GO:0031060)3.05846700
79regulation of cytokine production involved in inflammatory response (GO:1900015)3.05501549
80gene silencing (GO:0016458)3.04812761
81nucleus organization (GO:0006997)3.04413023
82hyperosmotic salinity response (GO:0042538)3.02444788
83oocyte maturation (GO:0001556)3.02085669
84histone H3-K9 demethylation (GO:0033169)3.02079069
85phosphorelay signal transduction system (GO:0000160)3.00176914
86aggressive behavior (GO:0002118)2.99872022
87regulation of histone H3-K4 methylation (GO:0051569)2.97614946
88centriole assembly (GO:0098534)2.96801531
89regulation of reproductive process (GO:2000241)2.96524188
90DNA replication-dependent nucleosome organization (GO:0034723)2.96130562
91DNA replication-dependent nucleosome assembly (GO:0006335)2.96130562
92regulation of female receptivity (GO:0045924)2.93710999
93N-terminal protein amino acid acetylation (GO:0006474)2.93081795
94regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0000079)2.91058334
95dopamine biosynthetic process (GO:0042416)2.86853187
96amino acid import (GO:0043090)2.85766500
97regulation of steroid hormone biosynthetic process (GO:0090030)2.84115498
98negative regulation of retinoic acid receptor signaling pathway (GO:0048387)16.0508614
99regulation of retinoic acid receptor signaling pathway (GO:0048385)13.6123120
100regulation of DNA methylation (GO:0044030)10.5811843

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse6.00770812
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.30938595
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse5.14506199
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.62711863
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.62711863
6KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.62711863
7E2F7_22180533_ChIP-Seq_HELA_Human4.29779310
8FOXM1_23109430_ChIP-Seq_U2OS_Human3.47428757
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.41356702
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.23843578
11NOTCH1_21737748_ChIP-Seq_TLL_Human2.95665006
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.91475531
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.83915804
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.55484739
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.52187421
16PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.28579892
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.19185017
18HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.08220491
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.00993787
20EZH2_22144423_ChIP-Seq_EOC_Human10.6107039
21RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.89155694
22BP1_19119308_ChIP-ChIP_Hs578T_Human1.77978704
23IRF1_19129219_ChIP-ChIP_H3396_Human1.76555779
24GATA1_26923725_Chip-Seq_HPCs_Mouse1.75451194
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.67953117
26CREB1_15753290_ChIP-ChIP_HEK293T_Human1.67869023
27AR_21909140_ChIP-Seq_LNCAP_Human1.67520518
28TP63_19390658_ChIP-ChIP_HaCaT_Human1.58617348
29TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.35952982
30NANOG_18555785_ChIP-Seq_MESCs_Mouse1.32864502
31STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.32202496
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28133114
33GBX2_23144817_ChIP-Seq_PC3_Human1.26443093
34ESR1_15608294_ChIP-ChIP_MCF-7_Human1.24504498
35NANOG_20526341_ChIP-Seq_ESCs_Human1.21063445
36GABP_17652178_ChIP-ChIP_JURKAT_Human1.17618798
37YY1_21170310_ChIP-Seq_MESCs_Mouse1.17303366
38EST1_17652178_ChIP-ChIP_JURKAT_Human1.15913842
39LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14499685
40UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12574225
41ZNF274_21170338_ChIP-Seq_K562_Hela1.12185687
42SALL1_21062744_ChIP-ChIP_HESCs_Human1.10396178
43HTT_18923047_ChIP-ChIP_STHdh_Human1.09224674
44NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.05407135
45TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00335780
46NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.99770563
47FOXP3_21729870_ChIP-Seq_TREG_Human0.98381189
48MYC_19079543_ChIP-ChIP_MESCs_Mouse0.97979974
49POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.96540081
50SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.94169110
51PRDM14_20953172_ChIP-Seq_ESCs_Human0.93726394
52MYC_18940864_ChIP-ChIP_HL60_Human0.90723586
53NELFA_20434984_ChIP-Seq_ESCs_Mouse0.90686281
54EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.88971000
55EP300_21415370_ChIP-Seq_HL-1_Mouse0.86775907
56TP53_22573176_ChIP-Seq_HFKS_Human0.85909793
57TCF4_23295773_ChIP-Seq_U87_Human0.81229767
58CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.81099846
59KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.81026117
60CBP_21632823_ChIP-Seq_H3396_Human0.80686535
61GF1_26923725_Chip-Seq_HPCs_Mouse0.80557677
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.79305740
63CBP_20019798_ChIP-Seq_JUKART_Human0.79305740
64THAP11_20581084_ChIP-Seq_MESCs_Mouse0.79238980
65FOXH1_21741376_ChIP-Seq_EPCs_Human0.79179736
66SALL4_22934838_ChIP-ChIP_CD34+_Human0.79053473
67VDR_23849224_ChIP-Seq_CD4+_Human0.77496463
68PADI4_21655091_ChIP-ChIP_MCF-7_Human0.75871865
69AUTS2_25519132_ChIP-Seq_293T-REX_Human0.74163646
70CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.73903460
71ETS1_20019798_ChIP-Seq_JURKAT_Human0.73633383
72RUNX2_22187159_ChIP-Seq_PCA_Human0.71688998
73SOX2_18555785_ChIP-Seq_MESCs_Mouse0.71253463
74TBL1_22424771_ChIP-Seq_293T_Human0.69826258
75CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.68767019
76MYC_18555785_ChIP-Seq_MESCs_Mouse0.68171471
77SMAD4_21799915_ChIP-Seq_A2780_Human0.66259420
78GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.66189896
79RNF2_27304074_Chip-Seq_NSC_Mouse0.66032664
80NFYB_21822215_ChIP-Seq_K562_Human0.65922574
81EWS_26573619_Chip-Seq_HEK293_Human0.65865330
82LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.65172067
83AR_25329375_ChIP-Seq_VCAP_Human0.64896088
84FOXM1_26456572_ChIP-Seq_MCF-7_Human0.64861850
85PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.64397571
86TAL1_26923725_Chip-Seq_HPCs_Mouse0.62282813
87SMAD4_21741376_ChIP-Seq_EPCs_Human0.61956347
88CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.61820028
89GATA3_26560356_Chip-Seq_TH1_Human0.59232850
90STAT3_23295773_ChIP-Seq_U87_Human0.58197333
91BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.57960449
92KLF4_19829295_ChIP-Seq_ESCs_Human0.57935962
93* MYC_19030024_ChIP-ChIP_MESCs_Mouse0.57515194
94PKCTHETA_26484144_Chip-Seq_BREAST_Human0.57387393
95GATA1_19941827_ChIP-Seq_MEL86_Mouse0.56864600
96CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.56842376
97RBPJ_21746931_ChIP-Seq_IB4_Human0.56727463
98SOX2_19829295_ChIP-Seq_ESCs_Human0.56146313
99NANOG_19829295_ChIP-Seq_ESCs_Human0.56146313
100SMRT_27268052_Chip-Seq_Bcells_Human0.55605885

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect8.27613123
2MP0006292_abnormal_olfactory_placode4.86457935
3MP0008877_abnormal_DNA_methylation4.73376703
4MP0008789_abnormal_olfactory_epithelium4.61906293
5MP0005394_taste/olfaction_phenotype4.25776620
6MP0005499_abnormal_olfactory_system4.25776620
7MP0003890_abnormal_embryonic-extraembry3.28453802
8MP0005395_other_phenotype3.22701969
9MP0010030_abnormal_orbit_morphology2.91178847
10MP0003693_abnormal_embryo_hatching2.86293432
11MP0010234_abnormal_vibrissa_follicle2.71800108
12MP0005360_urolithiasis2.60284067
13MP0002139_abnormal_hepatobiliary_system2.48548123
14MP0008057_abnormal_DNA_replication2.45413277
15MP0003077_abnormal_cell_cycle2.41448698
16MP0003699_abnormal_female_reproductive2.33747216
17MP0002210_abnormal_sex_determination2.32670528
18MP0002138_abnormal_hepatobiliary_system2.24376663
19MP0002234_abnormal_pharynx_morphology2.22556214
20MP0001929_abnormal_gametogenesis2.12666857
21MP0005410_abnormal_fertilization2.10654563
22MP0010094_abnormal_chromosome_stability2.08424968
23MP0003879_abnormal_hair_cell1.98252404
24MP0008058_abnormal_DNA_repair1.97681337
25MP0003111_abnormal_nucleus_morphology1.84323893
26MP0003183_abnormal_peptide_metabolism1.81952962
27MP0001986_abnormal_taste_sensitivity1.74857359
28MP0002160_abnormal_reproductive_system1.74270649
29MP0000653_abnormal_sex_gland1.72858903
30MP0003950_abnormal_plasma_membrane1.70056904
31MP0002161_abnormal_fertility/fecundity1.62357700
32MP0010307_abnormal_tumor_latency1.58676504
33MP0008932_abnormal_embryonic_tissue1.56420762
34MP0000566_synostosis1.52620813
35MP0001145_abnormal_male_reproductive1.51668133
36MP0005647_abnormal_sex_gland1.48731939
37MP0001293_anophthalmia1.37367909
38MP0009840_abnormal_foam_cell1.36096933
39MP0004957_abnormal_blastocyst_morpholog1.29741622
40MP0003698_abnormal_male_reproductive1.27993573
41MP0000762_abnormal_tongue_morphology1.27867324
42MP0003121_genomic_imprinting1.25314495
43MP0001984_abnormal_olfaction1.24926709
44MP0001730_embryonic_growth_arrest1.20484464
45MP0002233_abnormal_nose_morphology1.18273139
46MP0001119_abnormal_female_reproductive1.07820788
47MP0005646_abnormal_pituitary_gland1.06566657
48MP0009379_abnormal_foot_pigmentation1.05851188
49MP0005389_reproductive_system_phenotype1.04154148
50MP0002796_impaired_skin_barrier1.03990084
51MP0000350_abnormal_cell_proliferation1.02572301
52MP0001672_abnormal_embryogenesis/_devel1.02527171
53MP0005380_embryogenesis_phenotype1.02527171
54MP0000631_abnormal_neuroendocrine_gland1.02048721
55MP0006276_abnormal_autonomic_nervous0.98865362
56MP0003119_abnormal_digestive_system0.95749484
57MP0004142_abnormal_muscle_tone0.93184730
58MP0003252_abnormal_bile_duct0.93070573
59MP0005085_abnormal_gallbladder_physiolo0.78050803
60MP0010368_abnormal_lymphatic_system0.77587143
61MP0000427_abnormal_hair_cycle0.77511547
62MP0000049_abnormal_middle_ear0.76975502
63MP0002127_abnormal_cardiovascular_syste0.76456007
64MP0005501_abnormal_skin_physiology0.71726067
65MP0003136_yellow_coat_color0.67729881
66MP0002272_abnormal_nervous_system0.67248152
67MP0002084_abnormal_developmental_patter0.64387112
68MP0001502_abnormal_circadian_rhythm0.62590672
69MP0001324_abnormal_eye_pigmentation0.62436192
70MP0005551_abnormal_eye_electrophysiolog0.62053152
71MP0001666_abnormal_nutrient_absorption0.60864835
72MP0010678_abnormal_skin_adnexa0.59456296
73MP0003941_abnormal_skin_development0.56094950
74MP0003984_embryonic_growth_retardation0.53254815
75MP0002085_abnormal_embryonic_tissue0.52629629
76MP0005423_abnormal_somatic_nervous0.52318918
77MP0001881_abnormal_mammary_gland0.50201293
78MP0002751_abnormal_autonomic_nervous0.49948744
79MP0001697_abnormal_embryo_size0.49581569
80MP0002088_abnormal_embryonic_growth/wei0.49330478
81MP0000428_abnormal_craniofacial_morphol0.48672768
82MP0002090_abnormal_vision0.46606016
83MP0005075_abnormal_melanosome_morpholog0.46474324
84MP0003935_abnormal_craniofacial_develop0.44997138
85MP0002873_normal_phenotype0.44942521
86MP0002169_no_abnormal_phenotype0.44585097
87MP0000678_abnormal_parathyroid_gland0.42983614
88MP0002089_abnormal_postnatal_growth/wei0.40289433
89MP0005197_abnormal_uvea_morphology0.39460797
90MP0002080_prenatal_lethality0.39368906
91MP0000313_abnormal_cell_death0.38655456
92MP0001664_abnormal_digestion0.37827152
93MP0003787_abnormal_imprinting0.37480599
94MP0003755_abnormal_palate_morphology0.36891054
95MP0001963_abnormal_hearing_physiology0.36159398
96MP0002638_abnormal_pupillary_reflex0.34919227
97MP0000015_abnormal_ear_pigmentation0.34397985
98MP0004381_abnormal_hair_follicle0.33146059
99MP0003936_abnormal_reproductive_system0.31094076
100MP0002735_abnormal_chemical_nociception0.31067860

Predicted human phenotypes

RankGene SetZ-score
1Supernumerary spleens (HP:0009799)6.77676120
2Abdominal situs inversus (HP:0003363)5.54747768
3Abnormality of abdominal situs (HP:0011620)5.54747768
4Facial hemangioma (HP:0000329)4.79946061
5Malnutrition (HP:0004395)4.69688003
6Male infertility (HP:0003251)4.64404826
7Osteomalacia (HP:0002749)4.62616797
8Hypoplasia of the fovea (HP:0007750)4.62320205
9Aplasia/Hypoplasia of the fovea (HP:0008060)4.62320205
10Septo-optic dysplasia (HP:0100842)4.52467332
11Abnormal gallbladder physiology (HP:0012438)4.50043522
12Cholecystitis (HP:0001082)4.50043522
13Oligodactyly (hands) (HP:0001180)4.33763489
14Premature ovarian failure (HP:0008209)4.30282642
15Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)4.16805096
16Absent septum pellucidum (HP:0001331)4.11176534
17Abnormality of the fovea (HP:0000493)3.99305151
18Hypophosphatemic rickets (HP:0004912)3.97838534
19Azoospermia (HP:0000027)3.91193208
20Abnormality of the labia minora (HP:0012880)3.90489263
21Lip pit (HP:0100267)3.85701675
22Chromsome breakage (HP:0040012)3.80008028
23Abnormality of the septum pellucidum (HP:0007375)3.78669501
24Short tibia (HP:0005736)3.77228607
25Chromosomal breakage induced by crosslinking agents (HP:0003221)3.71526839
26Impulsivity (HP:0100710)3.70091402
27Median cleft lip (HP:0000161)3.63509054
28Infertility (HP:0000789)3.53447560
29Gonadotropin excess (HP:0000837)3.47252179
30Aplasia/Hypoplasia of the tibia (HP:0005772)3.32109930
31Anterior segment dysgenesis (HP:0007700)3.24818991
32Wrist flexion contracture (HP:0001239)3.21787839
33Oligodactyly (HP:0012165)3.11241389
34Sensory axonal neuropathy (HP:0003390)3.07328344
35Stillbirth (HP:0003826)3.04779597
36Abnormal spermatogenesis (HP:0008669)3.01958339
37Enlarged penis (HP:0000040)3.01028605
38Aplasia/Hypoplasia of the macula (HP:0008059)2.93836733
39Papillary thyroid carcinoma (HP:0002895)2.87874188
40Capillary hemangiomas (HP:0005306)2.86160495
41Muscle stiffness (HP:0003552)2.76447489
42Aplasia/Hypoplasia affecting the retina (HP:0008061)2.68451878
43Ankle contracture (HP:0006466)2.64410022
44Hypokinesia (HP:0002375)2.62565144
45Conjunctival telangiectasia (HP:0000524)2.57612795
46Fair hair (HP:0002286)2.54207197
47Abnormality of the phalanges of the hallux (HP:0010057)2.49042490
48Maternal diabetes (HP:0009800)2.43408513
49Urethral obstruction (HP:0000796)2.42663699
50Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.40630751
51Proximal tubulopathy (HP:0000114)2.28372269
52Aplasia/Hypoplasia of the tongue (HP:0010295)2.27484941
53Absent radius (HP:0003974)2.26029482
54Rhinitis (HP:0012384)2.25500139
55Abnormal lung lobation (HP:0002101)2.25020311
56Skin pits (HP:0100276)2.24754655
57Myokymia (HP:0002411)2.23084617
58Posterior subcapsular cataract (HP:0007787)2.21813409
59Apathy (HP:0000741)2.20922150
60Abnormal ciliary motility (HP:0012262)2.20545530
61Cleft eyelid (HP:0000625)2.20333535
62Loss of speech (HP:0002371)2.17941763
63Metaphyseal irregularity (HP:0003025)2.17249570
64Intrahepatic cholestasis (HP:0001406)2.16749826
65Diminished motivation (HP:0000745)2.16465181
66Meckel diverticulum (HP:0002245)2.16206035
67Steatorrhea (HP:0002570)2.13796477
68Absent forearm bone (HP:0003953)2.12084147
69Aplasia involving forearm bones (HP:0009822)2.12084147
70Generalized aminoaciduria (HP:0002909)2.09913471
71Abnormality of the preputium (HP:0100587)2.09149539
72Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.08161539
73Abnormality of the ileum (HP:0001549)2.07523861
74Aplasia/Hypoplasia of the uvula (HP:0010293)2.05929250
75Hip contracture (HP:0003273)2.04945826
76Limb hypertonia (HP:0002509)2.03109178
77Spinal cord compression (HP:0002176)2.01358802
78Anhidrosis (HP:0000970)2.00846731
79Hypercortisolism (HP:0001578)1.99449044
80Abnormality of the vasculature of the conjunctiva (HP:0008054)1.98701873
81Abnormality of monocarboxylic acid metabolism (HP:0010996)1.97767908
82Abnormality of chromosome stability (HP:0003220)1.97022065
83Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.96911119
84Lower limb hyperreflexia (HP:0002395)1.96509796
85Truncal obesity (HP:0001956)1.93036426
86Bicornuate uterus (HP:0000813)1.92768396
87Aplasia of the musculature (HP:0100854)1.89401459
88Hypohidrosis (HP:0000966)1.84434315
89Nephroblastoma (Wilms tumor) (HP:0002667)1.83386723
90Congenital sensorineural hearing impairment (HP:0008527)1.82444013
91Abnormality of calcium-phosphate metabolism (HP:0100530)1.81084335
92Hypoplasia of the uterus (HP:0000013)1.80134892
93Abnormality of aromatic amino acid family metabolism (HP:0004338)1.78050037
94Microglossia (HP:0000171)1.77727648
95Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.76119139
96Abnormal tarsal ossification (HP:0008369)1.76028776
97Nausea (HP:0002018)1.75751365
98Short thumb (HP:0009778)1.74246919
99Heterotopia (HP:0002282)1.73969594
100Horseshoe kidney (HP:0000085)1.73851428

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K96.46872477
2ARAF5.83242307
3MAP3K135.72886231
4BRAF3.05545545
5NEK63.03474252
6STK242.98087220
7TTK2.85253263
8CDK92.65243661
9MOS2.54642074
10TAOK32.42688861
11EIF2AK32.13307483
12AURKA2.09494013
13KSR22.08295197
14RAF12.07340213
15BUB11.88821675
16PBK1.86751488
17MET1.83959797
18CDC71.79923119
19LMTK21.76326159
20PRKCI1.67455609
21ZAK1.54697672
22PLK11.50807685
23TRIM281.43186179
24SRPK11.37645137
25CDK71.37488573
26STK31.35026989
27TESK21.30511412
28CDK191.24102869
29NTRK21.18587049
30KSR11.17166454
31NUAK11.12924021
32PLK31.09102205
33CDK121.07224035
34PIM11.01707920
35MAP3K81.01410689
36LATS20.99605351
37DMPK0.96529388
38BRSK20.95853749
39BRSK10.95648368
40MELK0.95044646
41STK390.91498139
42NEK20.90012237
43NEK90.85944384
44MARK30.84430779
45TIE10.84101503
46CHEK20.82893229
47AURKB0.82447542
48MST40.82096899
49CHEK10.75958020
50CDK20.69541550
51TNIK0.64976526
52PAK10.62771072
53LRRK20.59414141
54EEF2K0.56096881
55NTRK30.56065864
56ACVR1B0.54189764
57VRK10.53281317
58PLK40.52978786
59ATR0.52099394
60MAPKAPK30.51119714
61CDK10.50430525
62PKN10.49723497
63WNK10.49447455
64BMPR1B0.47589035
65PRKG10.47038815
66ATM0.46515646
67CSNK1G10.44867738
68STK40.44177469
69OXSR10.43037346
70TNK20.42678290
71STK160.41274109
72CSNK1D0.41003104
73CSNK1E0.40459929
74CDK80.39905521
75MAP3K50.38109478
76CAMK2A0.35347319
77TLK10.30830808
78AKT20.28981381
79NME10.27823302
80PRKCZ0.25185978
81PRKACA0.24578353
82MAPK10.24037999
83MTOR0.23795034
84CHUK0.23117487
85TGFBR10.22724251
86PTK20.22121205
87PRKACB0.22105662
88MAPK130.20865823
89CSNK1G30.20077008
90GSK3B0.19305633
91MAP3K10.19205475
92EIF2AK20.18481547
93CSNK2A20.17910630
94CDK50.17245176
95PDK10.16102529
96EGFR0.14982399
97CSNK2A10.14514434
98MAP2K10.13289830
99CDK11A0.13157082
100PINK10.13035906

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal transcription factors_Homo sapiens_hsa030225.76955224
2Cell cycle_Homo sapiens_hsa041104.65795508
3Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005334.61726700
4Mismatch repair_Homo sapiens_hsa034303.66610636
5Folate biosynthesis_Homo sapiens_hsa007903.54325514
6Oocyte meiosis_Homo sapiens_hsa041143.41396126
7Base excision repair_Homo sapiens_hsa034102.86738072
8Caffeine metabolism_Homo sapiens_hsa002322.72220005
9RNA degradation_Homo sapiens_hsa030182.69377093
10DNA replication_Homo sapiens_hsa030302.46892820
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.40302580
12Homologous recombination_Homo sapiens_hsa034402.37656212
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.29340913
14Fanconi anemia pathway_Homo sapiens_hsa034602.23650067
15Nucleotide excision repair_Homo sapiens_hsa034202.23023567
16RNA transport_Homo sapiens_hsa030132.22802540
17Ovarian steroidogenesis_Homo sapiens_hsa049132.22740404
18Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.20808696
19RNA polymerase_Homo sapiens_hsa030201.97565959
20Cysteine and methionine metabolism_Homo sapiens_hsa002701.86220164
21p53 signaling pathway_Homo sapiens_hsa041151.85210728
22Olfactory transduction_Homo sapiens_hsa047401.79623169
23Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.69432984
24mRNA surveillance pathway_Homo sapiens_hsa030151.63761067
25Dorso-ventral axis formation_Homo sapiens_hsa043201.63522230
26Circadian rhythm_Homo sapiens_hsa047101.37271025
27Regulation of autophagy_Homo sapiens_hsa041401.26396560
28Ribosome_Homo sapiens_hsa030101.13666620
29Spliceosome_Homo sapiens_hsa030400.99087634
30Fatty acid elongation_Homo sapiens_hsa000620.97343290
31SNARE interactions in vesicular transport_Homo sapiens_hsa041300.94582713
32Gap junction_Homo sapiens_hsa045400.84586273
33Taste transduction_Homo sapiens_hsa047420.82492052
34Phototransduction_Homo sapiens_hsa047440.82071229
35Thyroid cancer_Homo sapiens_hsa052160.80513084
36Nicotine addiction_Homo sapiens_hsa050330.77098592
37ABC transporters_Homo sapiens_hsa020100.74524091
38Synaptic vesicle cycle_Homo sapiens_hsa047210.71432107
39Inositol phosphate metabolism_Homo sapiens_hsa005620.68823216
40Viral carcinogenesis_Homo sapiens_hsa052030.67762240
41Purine metabolism_Homo sapiens_hsa002300.66610839
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.65683151
43Huntingtons disease_Homo sapiens_hsa050160.61161952
44Pyrimidine metabolism_Homo sapiens_hsa002400.60409728
45Vitamin digestion and absorption_Homo sapiens_hsa049770.60220328
46Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59720793
47Bile secretion_Homo sapiens_hsa049760.52257642
48TGF-beta signaling pathway_Homo sapiens_hsa043500.49874605
49Morphine addiction_Homo sapiens_hsa050320.49351593
50Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46715639
51HTLV-I infection_Homo sapiens_hsa051660.46124236
52Herpes simplex infection_Homo sapiens_hsa051680.40833779
53Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40603608
54Cardiac muscle contraction_Homo sapiens_hsa042600.40421063
55Serotonergic synapse_Homo sapiens_hsa047260.40103311
56GABAergic synapse_Homo sapiens_hsa047270.39536047
57MicroRNAs in cancer_Homo sapiens_hsa052060.39380860
58Small cell lung cancer_Homo sapiens_hsa052220.33893740
59Non-homologous end-joining_Homo sapiens_hsa034500.33757528
60FoxO signaling pathway_Homo sapiens_hsa040680.32922535
61mTOR signaling pathway_Homo sapiens_hsa041500.31942931
62Long-term depression_Homo sapiens_hsa047300.31765108
63Glycosaminoglycan degradation_Homo sapiens_hsa005310.29128212
64Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.28792550
65Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.28511690
66Drug metabolism - other enzymes_Homo sapiens_hsa009830.27647026
67Wnt signaling pathway_Homo sapiens_hsa043100.26924003
68Arginine and proline metabolism_Homo sapiens_hsa003300.26817501
69Hippo signaling pathway_Homo sapiens_hsa043900.24182679
70Epstein-Barr virus infection_Homo sapiens_hsa051690.19949655
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.16790793
72Proteasome_Homo sapiens_hsa030500.16768074
73Ras signaling pathway_Homo sapiens_hsa040140.15385718
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.14916486
75Thyroid hormone signaling pathway_Homo sapiens_hsa049190.14142686
76Adherens junction_Homo sapiens_hsa045200.13934489
77Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.12987702
78Longevity regulating pathway - mammal_Homo sapiens_hsa042110.12144143
79Protein digestion and absorption_Homo sapiens_hsa049740.11782484
80cGMP-PKG signaling pathway_Homo sapiens_hsa040220.10430993
81Oxytocin signaling pathway_Homo sapiens_hsa049210.09300882
82Hepatitis B_Homo sapiens_hsa051610.08741398
83Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.08297362
84Parkinsons disease_Homo sapiens_hsa050120.07700622
85Metabolic pathways_Homo sapiens_hsa011000.07533448
86Glycerophospholipid metabolism_Homo sapiens_hsa005640.07483247
87Propanoate metabolism_Homo sapiens_hsa006400.07159982
88Pyruvate metabolism_Homo sapiens_hsa006200.06445425
89Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.06244612
90Steroid biosynthesis_Homo sapiens_hsa001000.04497901
91Arginine biosynthesis_Homo sapiens_hsa002200.04135708
92Mineral absorption_Homo sapiens_hsa049780.03646526
93Maturity onset diabetes of the young_Homo sapiens_hsa049500.03519576
94Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.03039658
95Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.01896928
96ErbB signaling pathway_Homo sapiens_hsa040120.01837255
97Pathways in cancer_Homo sapiens_hsa052000.01835884
98Tight junction_Homo sapiens_hsa045300.01593612
99MAPK signaling pathway_Homo sapiens_hsa040100.01398479
100PI3K-Akt signaling pathway_Homo sapiens_hsa041510.00816946

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