DPRXP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hypothalamus development (GO:0021854)7.35704256
2dosage compensation (GO:0007549)6.37762258
3spinal cord association neuron differentiation (GO:0021527)6.30708636
4cellular ketone body metabolic process (GO:0046950)5.52796011
5protein prenylation (GO:0018342)5.26061078
6prenylation (GO:0097354)5.26061078
7ketone body metabolic process (GO:1902224)4.86789311
8regulation of type B pancreatic cell apoptotic process (GO:2000674)4.53489990
9olfactory bulb development (GO:0021772)4.50057580
10mitotic sister chromatid cohesion (GO:0007064)4.38797561
11positive regulation of amino acid transport (GO:0051957)4.24620926
12respiratory chain complex IV assembly (GO:0008535)4.09753880
13single strand break repair (GO:0000012)4.08612255
14protein K11-linked deubiquitination (GO:0035871)4.03881498
15cytochrome complex assembly (GO:0017004)4.00007517
16ventricular system development (GO:0021591)3.92399427
17base-excision repair, AP site formation (GO:0006285)3.85618326
18centriole replication (GO:0007099)3.83567626
19signal peptide processing (GO:0006465)3.79770160
20toxin metabolic process (GO:0009404)3.71148459
21protein K6-linked ubiquitination (GO:0085020)3.70649680
22regulation of pigment cell differentiation (GO:0050932)3.50891258
23attachment of spindle microtubules to kinetochore (GO:0008608)3.49953455
24neuron fate commitment (GO:0048663)3.45423387
25embryonic body morphogenesis (GO:0010172)3.44177345
26reciprocal meiotic recombination (GO:0007131)3.42808197
27reciprocal DNA recombination (GO:0035825)3.42808197
28histone mRNA catabolic process (GO:0071044)3.40641435
29preassembly of GPI anchor in ER membrane (GO:0016254)3.37238232
30ribosome assembly (GO:0042255)3.36304775
31microtubule severing (GO:0051013)3.34396462
32left/right pattern formation (GO:0060972)3.33511621
33negative regulation of oligodendrocyte differentiation (GO:0048715)3.32149444
34epithelial cilium movement (GO:0003351)3.31676788
35pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.29774103
36cell differentiation in spinal cord (GO:0021515)3.27363722
37carnitine metabolic process (GO:0009437)3.25687076
38startle response (GO:0001964)3.23841105
39phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.23819893
40intraciliary transport (GO:0042073)3.23406099
41eye photoreceptor cell development (GO:0042462)3.22262650
42regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.16326103
43alkaloid metabolic process (GO:0009820)3.15329548
44rRNA catabolic process (GO:0016075)3.13400796
45photoreceptor cell development (GO:0042461)3.12392383
46pancreas development (GO:0031016)3.11605376
47response to pheromone (GO:0019236)3.10990729
48coenzyme A metabolic process (GO:0015936)3.07631635
49negative regulation of neurological system process (GO:0031645)3.05950999
50homocysteine metabolic process (GO:0050667)3.05879213
51regulation of acyl-CoA biosynthetic process (GO:0050812)3.03379749
52protein localization to cilium (GO:0061512)2.99031715
53regulation of DNA endoreduplication (GO:0032875)2.96618437
54positive regulation of developmental pigmentation (GO:0048087)2.96519697
55pyrimidine nucleotide catabolic process (GO:0006244)2.96452088
56inner ear receptor cell development (GO:0060119)2.95556782
57somatic hypermutation of immunoglobulin genes (GO:0016446)2.93649450
58somatic diversification of immune receptors via somatic mutation (GO:0002566)2.93649450
59synaptic transmission, dopaminergic (GO:0001963)2.89788809
60nucleotide transmembrane transport (GO:1901679)2.88816218
61negative regulation of cytosolic calcium ion concentration (GO:0051481)2.88423105
62dopamine biosynthetic process (GO:0042416)2.86272951
63microtubule anchoring (GO:0034453)2.83828695
64peptidyl-lysine trimethylation (GO:0018023)2.81215030
65detection of light stimulus involved in visual perception (GO:0050908)2.80870093
66detection of light stimulus involved in sensory perception (GO:0050962)2.80870093
67negative regulation of protein oligomerization (GO:0032460)2.79614013
68G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.79571050
69regulation of nuclear cell cycle DNA replication (GO:0033262)2.78248630
70tyrosine metabolic process (GO:0006570)2.77934587
71axoneme assembly (GO:0035082)2.77457543
72ribonucleoside bisphosphate biosynthetic process (GO:0034030)2.75896358
73nucleoside bisphosphate biosynthetic process (GO:0033866)2.75896358
74purine nucleoside bisphosphate biosynthetic process (GO:0034033)2.75896358
75negative regulation of DNA-dependent DNA replication (GO:2000104)2.75625226
76regulation of growth hormone secretion (GO:0060123)2.74857476
77DNA deamination (GO:0045006)2.74764833
78regulation of centriole replication (GO:0046599)2.74076467
79anterograde synaptic vesicle transport (GO:0048490)2.73342487
80regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.72658315
81limb development (GO:0060173)2.72075858
82appendage development (GO:0048736)2.72075858
83cochlea development (GO:0090102)2.71744999
84RNA destabilization (GO:0050779)2.71360783
85regulation of oligodendrocyte differentiation (GO:0048713)2.71032361
86cytoplasmic mRNA processing body assembly (GO:0033962)2.70739050
87peptidyl-lysine methylation (GO:0018022)2.68458454
88negative regulation of DNA recombination (GO:0045910)2.67696241
89positive regulation of translational initiation (GO:0045948)2.66595068
90cAMP-mediated signaling (GO:0019933)2.66396962
91positive regulation of amine transport (GO:0051954)2.66121357
92water-soluble vitamin biosynthetic process (GO:0042364)2.65244033
93centriole assembly (GO:0098534)2.64501646
94positive regulation of growth hormone secretion (GO:0060124)2.63380501
95monoubiquitinated protein deubiquitination (GO:0035520)2.62461388
96innervation (GO:0060384)2.62115483
97negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.61791406
98body morphogenesis (GO:0010171)2.58122160
99intra-Golgi vesicle-mediated transport (GO:0006891)2.57946479
100replication fork processing (GO:0031297)2.57594772

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse7.85622527
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.70922135
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.66296608
4TAF15_26573619_Chip-Seq_HEK293_Human3.10606720
5POU3F2_20337985_ChIP-ChIP_501MEL_Human2.62224910
6GBX2_23144817_ChIP-Seq_PC3_Human2.38595527
7CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.37654015
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.36016559
9ELK1_19687146_ChIP-ChIP_HELA_Human2.25481354
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.21892943
11ZNF274_21170338_ChIP-Seq_K562_Hela2.15326591
12FUS_26573619_Chip-Seq_HEK293_Human2.10430686
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.08969581
14EWS_26573619_Chip-Seq_HEK293_Human2.08187934
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.03182532
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.01637659
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.90123473
18E2F7_22180533_ChIP-Seq_HELA_Human1.85408821
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.84783691
20KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.78982611
21IGF1R_20145208_ChIP-Seq_DFB_Human1.73633997
22AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.70708944
23EST1_17652178_ChIP-ChIP_JURKAT_Human1.63067820
24PADI4_21655091_ChIP-ChIP_MCF-7_Human1.62225933
25ER_23166858_ChIP-Seq_MCF-7_Human1.61099756
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.60063863
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.57944874
28STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.53987874
29IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.52573217
30CBP_20019798_ChIP-Seq_JUKART_Human1.52573217
31VDR_23849224_ChIP-Seq_CD4+_Human1.50243816
32SUZ12_27294783_Chip-Seq_NPCs_Mouse1.50160719
33PCGF2_27294783_Chip-Seq_NPCs_Mouse1.46259067
34STAT3_23295773_ChIP-Seq_U87_Human1.45595817
35IRF1_19129219_ChIP-ChIP_H3396_Human1.45022909
36P300_19829295_ChIP-Seq_ESCs_Human1.43480719
37KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.42505264
38GABP_17652178_ChIP-ChIP_JURKAT_Human1.39313113
39CREB1_15753290_ChIP-ChIP_HEK293T_Human1.39280911
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.39215452
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.39030793
42SMAD4_21799915_ChIP-Seq_A2780_Human1.38659160
43EGR1_19374776_ChIP-ChIP_THP-1_Human1.35070803
44EGR1_23403033_ChIP-Seq_LIVER_Mouse1.34413008
45OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34188200
46TP53_16413492_ChIP-PET_HCT116_Human1.30015714
47NFE2_27457419_Chip-Seq_LIVER_Mouse1.29753219
48UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.29474548
49EZH2_27294783_Chip-Seq_NPCs_Mouse1.27466541
50E2F1_21310950_ChIP-Seq_MCF-7_Human1.26824235
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.25799420
52EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.25539322
53TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.24408405
54NANOG_18555785_Chip-Seq_ESCs_Mouse1.23806992
55TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.20233713
56PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.19399102
57MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18619809
58POU5F1_16153702_ChIP-ChIP_HESCs_Human1.17139227
59HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.15587879
60MYC_18940864_ChIP-ChIP_HL60_Human1.13822966
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.12096174
62TCF4_23295773_ChIP-Seq_U87_Human1.11544202
63BCAT_22108803_ChIP-Seq_LS180_Human1.11308791
64FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.10857632
65P53_22387025_ChIP-Seq_ESCs_Mouse1.09010843
66TP53_22573176_ChIP-Seq_HFKS_Human1.05814062
67EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.05405081
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05305810
69PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.03792541
70SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03312514
71RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.02952151
72CTBP1_25329375_ChIP-Seq_LNCAP_Human1.02323671
73E2F1_18555785_Chip-Seq_ESCs_Mouse1.01214896
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.00282609
75AR_25329375_ChIP-Seq_VCAP_Human0.99610980
76KLF5_20875108_ChIP-Seq_MESCs_Mouse0.99082387
77NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98839409
78SOX2_19829295_ChIP-Seq_ESCs_Human0.98205470
79NANOG_19829295_ChIP-Seq_ESCs_Human0.98205470
80YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97664663
81FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97629969
82CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97082838
83AR_21572438_ChIP-Seq_LNCaP_Human0.95228113
84ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.93191074
85CDX2_22108803_ChIP-Seq_LS180_Human0.91784308
86P300_18555785_Chip-Seq_ESCs_Mouse0.91417984
87PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.91392531
88CMYC_18555785_Chip-Seq_ESCs_Mouse0.91195897
89EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.90612050
90TCF4_22108803_ChIP-Seq_LS180_Human0.90562219
91RUNX1_27457419_Chip-Seq_LIVER_Mouse0.90015171
92CRX_20693478_ChIP-Seq_RETINA_Mouse0.89592133
93NR3C1_23031785_ChIP-Seq_PC12_Mouse0.89409870
94OCT4_18555785_Chip-Seq_ESCs_Mouse0.89306729
95DCP1A_22483619_ChIP-Seq_HELA_Human0.88981491
96SALL4_22934838_ChIP-ChIP_CD34+_Human0.88387769
97FOXM1_26456572_ChIP-Seq_MCF-7_Human0.88133535
98RNF2_27304074_Chip-Seq_NSC_Mouse0.87262440
99STAT3_18555785_Chip-Seq_ESCs_Mouse0.86992430
100RUNX2_22187159_ChIP-Seq_PCA_Human0.85618199

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005645_abnormal_hypothalamus_physiol7.89917171
2MP0005646_abnormal_pituitary_gland6.66259477
3MP0008057_abnormal_DNA_replication5.90704061
4MP0009780_abnormal_chondrocyte_physiolo3.75940406
5MP0006072_abnormal_retinal_apoptosis3.07790100
6MP0003122_maternal_imprinting2.95610591
7MP0008877_abnormal_DNA_methylation2.74763861
8MP0005647_abnormal_sex_gland2.52582672
9MP0002009_preneoplasia2.49342761
10MP0000631_abnormal_neuroendocrine_gland2.36608648
11MP0003787_abnormal_imprinting2.35849227
12MP0005253_abnormal_eye_physiology2.35485805
13MP0003646_muscle_fatigue2.35408405
14MP0005220_abnormal_exocrine_pancreas2.19223335
15MP0003121_genomic_imprinting2.17924632
16MP0003011_delayed_dark_adaptation2.17311351
17MP0004043_abnormal_pH_regulation2.04096057
18MP0002102_abnormal_ear_morphology1.93681233
19MP0000372_irregular_coat_pigmentation1.93104528
20MP0003693_abnormal_embryo_hatching1.74367403
21MP0008875_abnormal_xenobiotic_pharmacok1.73948352
22MP0000427_abnormal_hair_cycle1.73889849
23MP0000013_abnormal_adipose_tissue1.71666861
24MP0005551_abnormal_eye_electrophysiolog1.69446014
25MP0008007_abnormal_cellular_replicative1.64412126
26MP0000383_abnormal_hair_follicle1.60956532
27MP0005083_abnormal_biliary_tract1.59040799
28MP0010094_abnormal_chromosome_stability1.49879830
29MP0002837_dystrophic_cardiac_calcinosis1.41338568
30MP0001188_hyperpigmentation1.35046940
31MP0003786_premature_aging1.32176969
32MP0008058_abnormal_DNA_repair1.31566007
33MP0001944_abnormal_pancreas_morphology1.27088429
34MP0010678_abnormal_skin_adnexa1.24761242
35MP0004147_increased_porphyrin_level1.13680332
36MP0006292_abnormal_olfactory_placode1.09361748
37MP0005367_renal/urinary_system_phenotyp1.09227607
38MP0000516_abnormal_urinary_system1.09227607
39MP0002928_abnormal_bile_duct1.05497156
40MP0010307_abnormal_tumor_latency1.04403501
41MP0002693_abnormal_pancreas_physiology1.02049391
42MP0008995_early_reproductive_senescence1.01835936
43MP0003283_abnormal_digestive_organ0.99733130
44MP0004142_abnormal_muscle_tone0.96578068
45MP0004133_heterotaxia0.96371901
46MP0002078_abnormal_glucose_homeostasis0.90718665
47MP0003698_abnormal_male_reproductive0.90093170
48MP0004019_abnormal_vitamin_homeostasis0.89658993
49MP0009046_muscle_twitch0.86691275
50MP0002751_abnormal_autonomic_nervous0.86033904
51MP0003890_abnormal_embryonic-extraembry0.85424850
52MP0001764_abnormal_homeostasis0.85113485
53MP0001529_abnormal_vocalization0.82043301
54MP0001929_abnormal_gametogenesis0.81128890
55MP0005391_vision/eye_phenotype0.79581695
56MP0005084_abnormal_gallbladder_morpholo0.79537858
57MP0001968_abnormal_touch/_nociception0.78749898
58MP0001984_abnormal_olfaction0.77842925
59MP0003950_abnormal_plasma_membrane0.76341329
60MP0002166_altered_tumor_susceptibility0.75961095
61MP0003195_calcinosis0.75641189
62MP0004924_abnormal_behavior0.75609949
63MP0005386_behavior/neurological_phenoty0.75609949
64MP0005174_abnormal_tail_pigmentation0.71195620
65MP0003937_abnormal_limbs/digits/tail_de0.69992135
66MP0004270_analgesia0.69736300
67MP0001270_distended_abdomen0.68614067
68MP0010329_abnormal_lipoprotein_level0.68590355
69MP0002163_abnormal_gland_morphology0.67332925
70MP0010386_abnormal_urinary_bladder0.65611202
71MP0002909_abnormal_adrenal_gland0.65260151
72MP0003718_maternal_effect0.64076105
73MP0002090_abnormal_vision0.63875283
74MP0008932_abnormal_embryonic_tissue0.63177642
75MP0001879_abnormal_lymphatic_vessel0.63145845
76MP0004957_abnormal_blastocyst_morpholog0.62870375
77MP0002938_white_spotting0.62513245
78MP0000569_abnormal_digit_pigmentation0.61783201
79MP0005187_abnormal_penis_morphology0.61459044
80MP0003137_abnormal_impulse_conducting0.60580195
81MP0002876_abnormal_thyroid_physiology0.59766584
82MP0008260_abnormal_autophagy0.59508785
83MP0002160_abnormal_reproductive_system0.57551587
84MP0001756_abnormal_urination0.56728770
85MP0004808_abnormal_hematopoietic_stem0.56006951
86MP0005448_abnormal_energy_balance0.55703540
87MP0000639_abnormal_adrenal_gland0.54238467
88MP0004134_abnormal_chest_morphology0.53691602
89MP0010352_gastrointestinal_tract_polyps0.53609039
90MP0004215_abnormal_myocardial_fiber0.52300456
91MP0002069_abnormal_eating/drinking_beha0.51992500
92MP0005397_hematopoietic_system_phenotyp0.51762833
93MP0001545_abnormal_hematopoietic_system0.51762833
94MP0002971_abnormal_brown_adipose0.51702599
95MP0005452_abnormal_adipose_tissue0.51536872
96MP0005167_abnormal_blood-brain_barrier0.51016275
97MP0003943_abnormal_hepatobiliary_system0.49382079
98MP0004197_abnormal_fetal_growth/weight/0.49235645
99MP0001145_abnormal_male_reproductive0.49033345
100MP0008872_abnormal_physiological_respon0.48729219

Predicted human phenotypes

RankGene SetZ-score
1Tubulointerstitial nephritis (HP:0001970)9.82652961
2Hyperglycinemia (HP:0002154)4.87811976
3Tubulointerstitial abnormality (HP:0001969)4.27449925
4Methylmalonic acidemia (HP:0002912)3.45464597
5Chromsome breakage (HP:0040012)3.38187225
6Ketoacidosis (HP:0001993)3.36383044
7Chronic hepatic failure (HP:0100626)3.21075578
8Dyschromatopsia (HP:0007641)3.17051154
9Medulloblastoma (HP:0002885)3.15623959
10Neonatal respiratory distress (HP:0002643)3.06703075
11Hematochezia (HP:0002573)3.02341325
12Metaphyseal dysplasia (HP:0100255)2.98855007
13Hypokinesia (HP:0002375)2.91661079
14Broad distal phalanx of finger (HP:0009836)2.91387306
15Fibular hypoplasia (HP:0003038)2.88602346
16Hyperkalemia (HP:0002153)2.71264836
17Methylmalonic aciduria (HP:0012120)2.64767627
18Fair hair (HP:0002286)2.63922443
19Hypobetalipoproteinemia (HP:0003563)2.58583373
20Abnormality of chromosome stability (HP:0003220)2.54591681
21Diminished movement (HP:0002374)2.53738340
22Abnormality of vitamin B metabolism (HP:0004340)2.53405956
23Abnormality of the labia minora (HP:0012880)2.52753265
24Progressive microcephaly (HP:0000253)2.52342286
25Short chin (HP:0000331)2.50241676
26Abnormality of glycine metabolism (HP:0010895)2.47170287
27Abnormality of serine family amino acid metabolism (HP:0010894)2.47170287
28Volvulus (HP:0002580)2.45696898
29Gaze-evoked nystagmus (HP:0000640)2.44230159
30Amyotrophic lateral sclerosis (HP:0007354)2.36760408
31Renal cortical cysts (HP:0000803)2.34187140
32Abnormality of serum amino acid levels (HP:0003112)2.31694886
33Ependymoma (HP:0002888)2.31519353
34Abnormality of the renal medulla (HP:0100957)2.17684251
35Thyroiditis (HP:0100646)2.14701303
36Aplasia cutis congenita (HP:0001057)2.14506454
37Abnormality of the vitamin B12 metabolism (HP:0004341)2.14268775
38Colon cancer (HP:0003003)2.10834340
39Hyperventilation (HP:0002883)2.03879006
40Chromosomal breakage induced by crosslinking agents (HP:0003221)2.03276142
41Labial hypoplasia (HP:0000066)2.02041619
42Abnormality of the renal cortex (HP:0011035)2.01753549
43Rhinitis (HP:0012384)1.99742756
44Albinism (HP:0001022)1.98317791
45Failure to thrive in infancy (HP:0001531)1.95044940
46Optic nerve hypoplasia (HP:0000609)1.94705899
47Enlarged kidneys (HP:0000105)1.89928521
48Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.88128461
49Short 1st metacarpal (HP:0010034)1.88128461
50Neoplasm of the tracheobronchial system (HP:0100552)1.87492739
51Submucous cleft hard palate (HP:0000176)1.87151592
52Dyskinesia (HP:0100660)1.87121107
53Astrocytoma (HP:0009592)1.85986041
54Abnormality of the astrocytes (HP:0100707)1.85986041
55Widely spaced teeth (HP:0000687)1.84014562
56Ketosis (HP:0001946)1.82056099
57Rhabdomyosarcoma (HP:0002859)1.81325873
58Abnormality of vitamin metabolism (HP:0100508)1.79803690
59Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.79302415
60Polyphagia (HP:0002591)1.78336082
61Nephronophthisis (HP:0000090)1.76721419
62Hypogonadotrophic hypogonadism (HP:0000044)1.76114113
63Hypoplastic female external genitalia (HP:0012815)1.75994514
64Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.75522853
65Abnormality of alanine metabolism (HP:0010916)1.75522853
66Hyperalaninemia (HP:0003348)1.75522853
67Hyperinsulinemic hypoglycemia (HP:0000825)1.74899823
68Abnormal respiratory motile cilium morphology (HP:0005938)1.74360175
69Abnormal respiratory epithelium morphology (HP:0012253)1.74360175
70Neoplasm of the oral cavity (HP:0100649)1.74307900
71Slow-growing hair (HP:0002217)1.74012172
72Abnormality of hair growth rate (HP:0011363)1.74012172
73Hyperammonemia (HP:0001987)1.73695029
74Stage 5 chronic kidney disease (HP:0003774)1.73432543
75Sandal gap (HP:0001852)1.73420318
76Aplasia/Hypoplasia of the uvula (HP:0010293)1.72667876
77Exocrine pancreatic insufficiency (HP:0001738)1.72207826
78Horizontal nystagmus (HP:0000666)1.71541560
79Metabolic acidosis (HP:0001942)1.70960541
80Abnormal pancreas size (HP:0012094)1.69422321
81Opisthotonus (HP:0002179)1.68748788
82Abnormality of the labia majora (HP:0012881)1.68013910
83Abnormality of potassium homeostasis (HP:0011042)1.67588263
84Hypomagnesemia (HP:0002917)1.67009841
85Papillary thyroid carcinoma (HP:0002895)1.66311817
86Aplasia/Hypoplasia of the earlobes (HP:0009906)1.66186109
87Abnormality of the labia (HP:0000058)1.66174881
88Attenuation of retinal blood vessels (HP:0007843)1.66039001
89Biliary tract neoplasm (HP:0100574)1.63730827
90Abnormal ciliary motility (HP:0012262)1.62272646
91Abnormal albumin level (HP:0012116)1.60925315
92Hypoalbuminemia (HP:0003073)1.60925315
93Short humerus (HP:0005792)1.60446793
94Abnormality of the pancreatic islet cells (HP:0006476)1.60012499
95Abnormality of endocrine pancreas physiology (HP:0012093)1.60012499
96Generalized hypopigmentation of hair (HP:0011358)1.59525373
97Hypotelorism (HP:0000601)1.58947989
98Calf muscle hypertrophy (HP:0008981)1.58775608
99Abnormality of the 1st metacarpal (HP:0010009)1.58310929
100Myelodysplasia (HP:0002863)1.58038857

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT35.59459238
2FRK5.22154887
3BUB13.28300151
4WNK33.22169746
5TNIK3.22050268
6ZAK2.76053812
7BRD42.55764737
8BMPR22.55446303
9TLK12.31249795
10EIF2AK32.24337265
11TRIM281.97676874
12ACVR1B1.87343310
13ERBB31.66113508
14MAP3K41.61480738
15PIK3CG1.59645931
16PLK41.56417271
17PLK21.46005086
18FLT31.40788097
19YES11.40608309
20TSSK61.40188804
21PASK1.38203143
22ADRBK21.34794819
23MKNK21.34756296
24ATR1.31316625
25RPS6KA51.28710947
26BMPR1B1.25887987
27BRSK21.22670097
28BRAF1.18874673
29MAP2K71.17297467
30MAPKAPK51.14529013
31NEK11.14466426
32NLK1.13461038
33CDK31.13272845
34MAP4K21.11440395
35TRPM71.06455484
36ADRBK11.01555662
37MKNK11.00310083
38WEE11.00009261
39PIK3CA0.97622598
40CSNK1A1L0.93196068
41TEC0.91206004
42PKN20.89053737
43DYRK20.83196270
44PTK2B0.79004454
45CAMK2D0.76915287
46PRKCE0.76764710
47CSNK1G30.75775652
48ATM0.74272613
49STK40.72145254
50STK160.70523111
51CSNK1G10.70309604
52SGK20.69591841
53FGFR20.65771863
54GRK10.65656777
55STK240.64284329
56MAP3K50.62308710
57CDC70.61895745
58STK30.60169268
59PIM20.59672037
60FER0.57946532
61PKN10.56845593
62CSNK1G20.56673144
63CDK120.55258478
64VRK10.53241343
65GSK3A0.52869493
66PNCK0.49848199
67NTRK30.48780946
68CDK50.48485047
69PLK30.47931236
70NEK60.47778061
71PIM10.47700487
72MAP3K70.46918612
73MAPK110.44264784
74MST40.42165894
75NEK20.41413412
76RAF10.40501559
77CHEK20.39342306
78PLK10.38699188
79IKBKB0.36936065
80PAK30.34944169
81STK390.34933538
82PDK20.34503452
83CHEK10.33930050
84PAK60.33547013
85HIPK20.33298740
86TNK20.31738547
87CAMK1G0.30875652
88PRKAA10.30580221
89PRKDC0.29108428
90PRKACB0.28179598
91AURKB0.27215959
92WNK40.26753319
93ABL10.26018523
94FGFR10.25764720
95CAMK2G0.25664071
96DDR20.25644333
97PINK10.25188204
98PRKCG0.25018830
99PRKCQ0.24399498
100OXSR10.24289947

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000725.82424334
2Fanconi anemia pathway_Homo sapiens_hsa034603.74846845
3Butanoate metabolism_Homo sapiens_hsa006503.57725621
4Non-homologous end-joining_Homo sapiens_hsa034503.27624486
5Systemic lupus erythematosus_Homo sapiens_hsa053223.11013208
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.92020245
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.84710064
8Nitrogen metabolism_Homo sapiens_hsa009102.84466652
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.75966120
10Homologous recombination_Homo sapiens_hsa034402.75590813
11Protein export_Homo sapiens_hsa030602.74311793
12Alcoholism_Homo sapiens_hsa050342.56401569
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.35726019
14Propanoate metabolism_Homo sapiens_hsa006402.14214798
15Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.91263141
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.88024333
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.82756436
18Selenocompound metabolism_Homo sapiens_hsa004501.81600329
19Sulfur metabolism_Homo sapiens_hsa009201.69526341
20Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.54766100
21Regulation of autophagy_Homo sapiens_hsa041401.33503715
22Cocaine addiction_Homo sapiens_hsa050301.33464216
23Sphingolipid metabolism_Homo sapiens_hsa006001.28960752
24Base excision repair_Homo sapiens_hsa034101.28838279
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.27739028
26Basal transcription factors_Homo sapiens_hsa030221.19602005
27Tryptophan metabolism_Homo sapiens_hsa003801.16412784
28Folate biosynthesis_Homo sapiens_hsa007901.16066788
29Vitamin B6 metabolism_Homo sapiens_hsa007501.10112961
30Phototransduction_Homo sapiens_hsa047441.09727003
31Mismatch repair_Homo sapiens_hsa034301.08482952
32Fatty acid degradation_Homo sapiens_hsa000711.05749785
33RNA degradation_Homo sapiens_hsa030181.05648487
34Fatty acid metabolism_Homo sapiens_hsa012121.01419589
35Insulin secretion_Homo sapiens_hsa049111.00376803
36Caffeine metabolism_Homo sapiens_hsa002320.97906891
37Primary bile acid biosynthesis_Homo sapiens_hsa001200.95885244
38One carbon pool by folate_Homo sapiens_hsa006700.93635659
39Hedgehog signaling pathway_Homo sapiens_hsa043400.93359384
40mTOR signaling pathway_Homo sapiens_hsa041500.93292820
41Taste transduction_Homo sapiens_hsa047420.92142621
42Circadian rhythm_Homo sapiens_hsa047100.92054882
43Olfactory transduction_Homo sapiens_hsa047400.89160706
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.87093750
45Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.86330240
46Glycerolipid metabolism_Homo sapiens_hsa005610.85054768
47RNA transport_Homo sapiens_hsa030130.77169901
48Lysine degradation_Homo sapiens_hsa003100.76586211
49Type I diabetes mellitus_Homo sapiens_hsa049400.72987696
50beta-Alanine metabolism_Homo sapiens_hsa004100.68204334
51FoxO signaling pathway_Homo sapiens_hsa040680.65306104
52Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.60761148
53Peroxisome_Homo sapiens_hsa041460.60551026
54Arginine biosynthesis_Homo sapiens_hsa002200.58562846
55N-Glycan biosynthesis_Homo sapiens_hsa005100.58283539
56Cell cycle_Homo sapiens_hsa041100.57308706
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52680971
58Basal cell carcinoma_Homo sapiens_hsa052170.51408572
59Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50643739
60RNA polymerase_Homo sapiens_hsa030200.49285514
61Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.47379791
62Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46886359
63SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46152276
64Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44747346
65Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41046738
66Nicotine addiction_Homo sapiens_hsa050330.40567380
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40558069
68Dorso-ventral axis formation_Homo sapiens_hsa043200.39975308
69Purine metabolism_Homo sapiens_hsa002300.39840922
70Amphetamine addiction_Homo sapiens_hsa050310.39627162
71Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.39001482
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38103234
73Viral carcinogenesis_Homo sapiens_hsa052030.37382360
74Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35566528
75p53 signaling pathway_Homo sapiens_hsa041150.35505194
76Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.35239112
77Metabolic pathways_Homo sapiens_hsa011000.34985571
78Nucleotide excision repair_Homo sapiens_hsa034200.33754176
79Mineral absorption_Homo sapiens_hsa049780.30738828
80Intestinal immune network for IgA production_Homo sapiens_hsa046720.28974502
81Prolactin signaling pathway_Homo sapiens_hsa049170.28303196
82TGF-beta signaling pathway_Homo sapiens_hsa043500.23622813
83Steroid biosynthesis_Homo sapiens_hsa001000.20877077
84Type II diabetes mellitus_Homo sapiens_hsa049300.20816370
85GABAergic synapse_Homo sapiens_hsa047270.20188227
86Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.19356783
87Inositol phosphate metabolism_Homo sapiens_hsa005620.19155692
88Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.18307799
89Morphine addiction_Homo sapiens_hsa050320.17627737
90Glucagon signaling pathway_Homo sapiens_hsa049220.17319636
91Endometrial cancer_Homo sapiens_hsa052130.16928283
92Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.16604060
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.16118694
94Prostate cancer_Homo sapiens_hsa052150.15622073
95Legionellosis_Homo sapiens_hsa051340.15004880
96Steroid hormone biosynthesis_Homo sapiens_hsa001400.14989669
97Wnt signaling pathway_Homo sapiens_hsa043100.12612123
98Circadian entrainment_Homo sapiens_hsa047130.12205206
99Serotonergic synapse_Homo sapiens_hsa047260.09441576
100Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.09148715

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