ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	dopamine transport (GO:0015872)	8.12931313
2	dopamine biosynthetic process (GO:0042416)	7.61354703
3	water-soluble vitamin biosynthetic process (GO:0042364)	6.76904999
4	phenol-containing compound catabolic process (GO:0019336)	6.00702499
5	nucleoside diphosphate catabolic process (GO:0009134)	5.71295815
6	catechol-containing compound biosynthetic process (GO:0009713)	5.54971740
7	catecholamine biosynthetic process (GO:0042423)	5.54971740
8	regulation of catecholamine metabolic process (GO:0042069)	5.48762949
9	regulation of dopamine metabolic process (GO:0042053)	5.48762949
10	negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)	5.36433467
11	catecholamine transport (GO:0051937)	4.88867446
12	autophagic vacuole fusion (GO:0000046)	4.68335216
13	neurotransmitter metabolic process (GO:0042133)	4.34651243
14	neurotransmitter biosynthetic process (GO:0042136)	4.21808381
15	exocrine pancreas development (GO:0031017)	4.14196045
16	organic cation transport (GO:0015695)	4.12375994
17	DNA deamination (GO:0045006)	4.02714891
18	regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)	3.89225051
19	prepulse inhibition (GO:0060134)	3.88977086
20	response to insecticide (GO:0017085)	3.87653562
21	organelle membrane fusion (GO:0090174)	3.85948527
22	response to xenobiotic stimulus (GO:0009410)	3.83842361
23	tyrosine metabolic process (GO:0006570)	3.80907157
24	ATP hydrolysis coupled proton transport (GO:0015991)	3.75335212
25	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	3.75335212
26	DNA replication-dependent nucleosome assembly (GO:0006335)	3.74428002
27	DNA replication-dependent nucleosome organization (GO:0034723)	3.74428002
28	kinetochore assembly (GO:0051382)	3.70416562
29	fucose catabolic process (GO:0019317)	3.67258836
30	L-fucose metabolic process (GO:0042354)	3.67258836
31	L-fucose catabolic process (GO:0042355)	3.67258836
32	transferrin transport (GO:0033572)	3.66843556
33	regulation of T-helper 1 cell differentiation (GO:0045625)	3.64390576
34	attachment of spindle microtubules to kinetochore (GO:0008608)	3.61251083
35	N-acetylneuraminate metabolic process (GO:0006054)	3.60842312
36	trivalent inorganic cation transport (GO:0072512)	3.59310914
37	ferric iron transport (GO:0015682)	3.59310914
38	translesion synthesis (GO:0019985)	3.57068198
39	signal peptide processing (GO:0006465)	3.53568657
40	regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)	3.52945327
41	viral mRNA export from host cell nucleus (GO:0046784)	3.48830349
42	DNA demethylation (GO:0080111)	3.44509372
43	negative regulation of T cell differentiation in thymus (GO:0033085)	3.29554517
44	multicellular organismal aging (GO:0010259)	3.28216644
45	dopamine metabolic process (GO:0042417)	3.27500866
46	neutrophil mediated immunity (GO:0002446)	3.27037916
47	carnitine transmembrane transport (GO:1902603)	3.26673557
48	phagosome maturation (GO:0090382)	3.25957497
49	spliceosomal complex assembly (GO:0000245)	3.23463900
50	regulation of DNA endoreduplication (GO:0032875)	3.22737304
51	histone H2B ubiquitination (GO:0033523)	3.21575090
52	kinetochore organization (GO:0051383)	3.21495645
53	alkaloid metabolic process (GO:0009820)	3.20374114
54	sulfation (GO:0051923)	3.19009661
55	replication fork processing (GO:0031297)	3.15819977
56	negative regulation of macrophage differentiation (GO:0045650)	3.12001614
57	response to iron ion (GO:0010039)	3.10946919
58	vitamin biosynthetic process (GO:0009110)	3.09766662
59	phenol-containing compound biosynthetic process (GO:0046189)	3.08090644
60	mast cell degranulation (GO:0043303)	3.07841369
61	mast cell activation involved in immune response (GO:0002279)	3.07841369
62	protein polyglutamylation (GO:0018095)	3.07741110
63	response to manganese ion (GO:0010042)	3.03815459
64	proline transport (GO:0015824)	3.02041176
65	pseudouridine synthesis (GO:0001522)	2.97111122
66	catechol-containing compound metabolic process (GO:0009712)	2.95768147
67	catecholamine metabolic process (GO:0006584)	2.95768147
68	carnitine transport (GO:0015879)	2.95567814
69	amino-acid betaine transport (GO:0015838)	2.95567814
70	phosphatidylethanolamine metabolic process (GO:0046337)	2.93587723
71	DNA double-strand break processing (GO:0000729)	2.93320833
72	DNA dealkylation (GO:0035510)	2.89865781
73	negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)	2.85145681
74	glycerophospholipid catabolic process (GO:0046475)	2.84153661
75	cellular ketone body metabolic process (GO:0046950)	2.83820325
76	monoamine transport (GO:0015844)	2.82819458
77	determination of adult lifespan (GO:0008340)	2.82772035
78	alanine transport (GO:0032328)	2.82139601
79	postreplication repair (GO:0006301)	2.79047094
80	rRNA catabolic process (GO:0016075)	2.78815049
81	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.76930423
82	oligosaccharide catabolic process (GO:0009313)	2.74431639
83	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.72321177
84	primary amino compound metabolic process (GO:1901160)	2.69318255
85	serotonin metabolic process (GO:0042428)	2.65992553
86	regulation of cellular respiration (GO:0043457)	2.65310589
87	cellular response to nicotine (GO:0071316)	2.63165058
88	kynurenine metabolic process (GO:0070189)	2.61871821
89	base-excision repair, AP site formation (GO:0006285)	2.60436521
90	activated T cell proliferation (GO:0050798)	2.58517071
91	rRNA methylation (GO:0031167)	2.58434042
92	vesicle transport along microtubule (GO:0047496)	2.55726682
93	regulation of T cell chemotaxis (GO:0010819)	2.55679408
94	positive regulation of T cell chemotaxis (GO:0010820)	2.55679408
95	norepinephrine metabolic process (GO:0042415)	2.55001069
96	iron ion transport (GO:0006826)	2.54681400
97	response to amphetamine (GO:0001975)	2.54650083
98	alpha-linolenic acid metabolic process (GO:0036109)	2.54537761
99	autophagic vacuole assembly (GO:0000045)	2.54523033
100	response to pheromone (GO:0019236)	13.1187881

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	5.60642186
2	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.27803956
3	AR_21572438_ChIP-Seq_LNCaP_Human	3.80860248
4	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.60203112
5	STAT6_21828071_ChIP-Seq_BEAS2B_Human	3.56928928
6	VDR_22108803_ChIP-Seq_LS180_Human	3.18686674
7	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.87747100
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.60230208
9	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.59072914
10	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.51797887
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.43374345
12	SCL_19346495_ChIP-Seq_HPC-7_Human	2.27134093
13	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.22762084
14	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.15065924
15	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.13161016
16	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.98021427
17	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.92606069
18	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.92251042
19	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.90224064
20	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.88095794
21	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.86879125
22	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.82886960
23	ELK1_19687146_ChIP-ChIP_HELA_Human	1.75180677
24	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.68236695
25	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.67716202
26	TAF15_26573619_Chip-Seq_HEK293_Human	1.58095482
27	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.57245610
28	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.48918747
29	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.46005267
30	ER_23166858_ChIP-Seq_MCF-7_Human	1.45650420
31	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.41027215
32	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.38920180
33	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.37723092
34	VDR_23849224_ChIP-Seq_CD4+_Human	1.31468104
35	NCOR_22424771_ChIP-Seq_293T_Human	1.31441876
36	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.29065169
37	TP53_22573176_ChIP-Seq_HFKS_Human	1.27576249
38	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.25376965
39	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.24350761
40	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.24350761
41	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	1.23813430
42	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.22533646
43	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.22364763
44	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.21876699
45	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.18492733
46	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.14175703
47	IRF1_19129219_ChIP-ChIP_H3396_Human	1.13764123
48	ERG_20517297_ChIP-Seq_VCAP_Human	1.13692256
49	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.11116887
50	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.09945677
51	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.09777258
52	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.09777258
53	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.09777258
54	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.09054600
55	LUZP1_20508642_ChIP-Seq_ESCs_Mouse	1.07324084
56	HOXB7_26014856_ChIP-Seq_BT474_Human	1.05457371
57	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.05080679
58	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.05037804
59	E2F7_22180533_ChIP-Seq_HELA_Human	1.04806716
60	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.03497326
61	EWS_26573619_Chip-Seq_HEK293_Human	1.02569806
62	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.02230799
63	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.02168057
64	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.01774907
65	TCF4_23295773_ChIP-Seq_U87_Human	1.00629490
66	FOXP3_21729870_ChIP-Seq_TREG_Human	0.99820165
67	SPI1_20517297_ChIP-Seq_HL60_Human	0.98243179
68	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	0.97934076
69	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	0.97271189
70	STAT3_23295773_ChIP-Seq_U87_Human	0.96780512
71	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.95287124
72	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	0.95162119
73	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.94216397
74	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.93125001
75	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.92358282
76	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.91821713
77	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.91763684
78	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.91588387
79	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.91366011
80	CBP_20019798_ChIP-Seq_JUKART_Human	0.91366011
81	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.91307478
82	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.90550669
83	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.89760120
84	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.89454318
85	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.88162189
86	RUNX_20019798_ChIP-Seq_JUKART_Human	0.87636752
87	GATA3_26560356_Chip-Seq_TH2_Human	0.87068608
88	SMRT_27268052_Chip-Seq_Bcells_Human	0.86541977
89	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.86383782
90	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.85828448
91	ETS1_20019798_ChIP-Seq_JURKAT_Human	0.84134949
92	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.82129955
93	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.82034428
94	P300_19829295_ChIP-Seq_ESCs_Human	0.81182778
95	CEBPB_22108803_ChIP-Seq_LS180_Human	0.81032956
96	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.79800093
97	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.79694374
98	GATA3_21867929_ChIP-Seq_TH1_Mouse	0.78668652
99	TAF2_19829295_ChIP-Seq_ESCs_Human	0.77662638
100	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.77639168

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002254_reproductive_system_inflammat	8.07098028
2	MP0004145_abnormal_muscle_electrophysio	4.35636028
3	MP0002876_abnormal_thyroid_physiology	3.92040910
4	MP0001905_abnormal_dopamine_level	3.59663609
5	MP0008872_abnormal_physiological_respon	3.47236666
6	MP0003878_abnormal_ear_physiology	2.90696526
7	MP0005377_hearing/vestibular/ear_phenot	2.90696526
8	MP0003786_premature_aging	2.57100647
9	MP0001346_abnormal_lacrimal_gland	2.48741037
10	MP0002160_abnormal_reproductive_system	2.47809001
11	MP0005171_absent_coat_pigmentation	2.46545984
12	MP0001348_abnormal_lacrimal_gland	2.26512002
13	MP0005389_reproductive_system_phenotype	2.04523252
14	MP0000427_abnormal_hair_cycle	2.03567189
15	MP0009046_muscle_twitch	2.02162012
16	MP0004133_heterotaxia	1.98901218
17	MP0000383_abnormal_hair_follicle	1.96867818
18	MP0002396_abnormal_hematopoietic_system	1.96569226
19	MP0005085_abnormal_gallbladder_physiolo	1.94230720
20	MP0001873_stomach_inflammation	1.93951725
21	MP0008877_abnormal_DNA_methylation	1.93842738
22	MP0000569_abnormal_digit_pigmentation	1.91011012
23	MP0003195_calcinosis	1.86976256
24	MP0005646_abnormal_pituitary_gland	1.56483325
25	MP0006035_abnormal_mitochondrial_morpho	1.50658811
26	MP0004043_abnormal_pH_regulation	1.48719289
27	MP0003950_abnormal_plasma_membrane	1.45535918
28	MP0005410_abnormal_fertilization	1.42789731
29	MP0000647_abnormal_sebaceous_gland	1.42634499
30	MP0000358_abnormal_cell_content/	1.34558520
31	MP0004147_increased_porphyrin_level	1.31987413
32	MP0006082_CNS_inflammation	1.31963931
33	MP0010094_abnormal_chromosome_stability	1.31145169
34	MP0003763_abnormal_thymus_physiology	1.25520720
35	MP0005174_abnormal_tail_pigmentation	1.25032419
36	MP0003045_fibrosis	1.24767363
37	MP0003718_maternal_effect	1.22059873
38	MP0001177_atelectasis	1.17352478
39	MP0001765_abnormal_ion_homeostasis	1.13887575
40	MP0003866_abnormal_defecation	1.12169954
41	MP0006036_abnormal_mitochondrial_physio	1.11720717
42	MP0001851_eye_inflammation	1.10828465
43	MP0008995_early_reproductive_senescence	1.08790829
44	MP0010678_abnormal_skin_adnexa	1.03850639
45	MP0005636_abnormal_mineral_homeostasis	1.00772338
46	MP0001293_anophthalmia	1.00426871
47	MP0009745_abnormal_behavioral_response	0.99966018
48	MP0001485_abnormal_pinna_reflex	0.96356710
49	MP0001919_abnormal_reproductive_system	0.93863788
50	MP0005584_abnormal_enzyme/coenzyme_acti	0.93046886
51	MP0005083_abnormal_biliary_tract	0.92661793
52	MP0001968_abnormal_touch/_nociception	0.91503889
53	MP0009697_abnormal_copulation	0.90920336
54	MP0009379_abnormal_foot_pigmentation	0.89551207
55	MP0000631_abnormal_neuroendocrine_gland	0.87885667
56	MP0002909_abnormal_adrenal_gland	0.86384326
57	MP0004885_abnormal_endolymph	0.86220828
58	MP0005310_abnormal_salivary_gland	0.85732754
59	MP0002822_catalepsy	0.85732182
60	MP0000470_abnormal_stomach_morphology	0.84357140
61	MP0000685_abnormal_immune_system	0.84077084
62	MP0002064_seizures	0.84051994
63	MP0005623_abnormal_meninges_morphology	0.83709082
64	MP0003136_yellow_coat_color	0.81985969
65	MP0001881_abnormal_mammary_gland	0.79996113
66	MP0002148_abnormal_hypersensitivity_rea	0.79079154
67	MP0001727_abnormal_embryo_implantation	0.78807400
68	MP0005395_other_phenotype	0.77757943
69	MP0003638_abnormal_response/metabolism_	0.77354169
70	MP0001800_abnormal_humoral_immune	0.77154916
71	MP0001986_abnormal_taste_sensitivity	0.72104020
72	MP0002136_abnormal_kidney_physiology	0.71818316
73	MP0005647_abnormal_sex_gland	0.69692066
74	MP0002452_abnormal_antigen_presenting	0.67635030
75	MP0001663_abnormal_digestive_system	0.67613142
76	MP0002102_abnormal_ear_morphology	0.65648086
77	MP0001958_emphysema	0.64253427
78	MP0009643_abnormal_urine_homeostasis	0.63362968
79	MP0000653_abnormal_sex_gland	0.62016140
80	MP0004019_abnormal_vitamin_homeostasis	0.60726592
81	MP0002168_other_aberrant_phenotype	0.60683481
82	MP0003303_peritoneal_inflammation	0.60581091
83	MP0000639_abnormal_adrenal_gland	0.60530577
84	MP0008058_abnormal_DNA_repair	0.60047665
85	MP0005645_abnormal_hypothalamus_physiol	0.59877347
86	MP0001929_abnormal_gametogenesis	0.59848184
87	MP0000372_irregular_coat_pigmentation	0.59737661
88	MP0004484_altered_response_of	0.58528476
89	MP0002277_abnormal_respiratory_mucosa	0.58151141
90	MP0008874_decreased_physiological_sensi	0.58147731
91	MP0001145_abnormal_male_reproductive	0.56442622
92	MP0003632_abnormal_nervous_system	0.56149493
93	MP0002736_abnormal_nociception_after	0.56144556
94	MP0002210_abnormal_sex_determination	0.55354550
95	MP0003693_abnormal_embryo_hatching	0.55322089
96	MP0004381_abnormal_hair_follicle	0.54678209
97	MP0005451_abnormal_body_composition	0.54390045
98	MP0000230_abnormal_systemic_arterial	0.53900191
99	MP0003943_abnormal_hepatobiliary_system	0.53098857
100	MP0002420_abnormal_adaptive_immunity	0.52652713

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Increased circulating renin level (HP:0000848)	7.72592502
2	Asplenia (HP:0001746)	7.35370164
3	Aplasia/Hypoplasia of the spleen (HP:0010451)	6.91859245
4	Limb dystonia (HP:0002451)	6.71315386
5	Hypokalemic alkalosis (HP:0001949)	6.21630797
6	Bilateral sensorineural hearing impairment (HP:0008619)	5.32632929
7	Hypokinesia (HP:0002375)	4.87793875
8	Tetany (HP:0001281)	4.85052076
9	Hypomagnesemia (HP:0002917)	4.50941059
10	Polydipsia (HP:0001959)	4.22352775
11	Abnormal drinking behavior (HP:0030082)	4.22352775
12	Supernumerary spleens (HP:0009799)	4.14813902
13	Amelogenesis imperfecta (HP:0000705)	3.88389930
14	Abnormality of renin-angiotensin system (HP:0000847)	3.82134742
15	Panhypogammaglobulinemia (HP:0003139)	3.73699441
16	Abnormality of magnesium homeostasis (HP:0004921)	3.72477512
17	Alkalosis (HP:0001948)	3.33246175
18	Paralysis (HP:0003470)	3.32679525
19	Hypoplasia of the thymus (HP:0000778)	3.26376366
20	Polyuria (HP:0000103)	3.20750768
21	Diminished movement (HP:0002374)	3.16861557
22	Abnormality of macular pigmentation (HP:0008002)	3.09295287
23	Abnormality of B cell number (HP:0010975)	3.06196259
24	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	2.99549849
25	Dyskinesia (HP:0100660)	2.96415382
26	True hermaphroditism (HP:0010459)	2.92226529
27	Renal tubular acidosis (HP:0001947)	2.87589023
28	Hypokalemia (HP:0002900)	2.72888451
29	B lymphocytopenia (HP:0010976)	2.70735000
30	Eosinophilia (HP:0001880)	2.63993844
31	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.62996573
32	Abnormal urine output (HP:0012590)	2.57068400
33	Abnormality of dental color (HP:0011073)	2.57034732
34	Congenital stationary night blindness (HP:0007642)	2.57016879
35	Pancreatic fibrosis (HP:0100732)	2.54676655
36	Pancreatic cysts (HP:0001737)	2.52070522
37	Abnormal biliary tract physiology (HP:0012439)	2.51096125
38	Bile duct proliferation (HP:0001408)	2.51096125
39	Tongue fasciculations (HP:0001308)	2.47515029
40	Chronic mucocutaneous candidiasis (HP:0002728)	2.46257052
41	Recurrent cutaneous fungal infections (HP:0011370)	2.46257052
42	Constricted visual fields (HP:0001133)	2.44145698
43	Patent foramen ovale (HP:0001655)	2.39026854
44	Conical tooth (HP:0000698)	2.28315518
45	Pendular nystagmus (HP:0012043)	2.27363685
46	Chronic hepatic failure (HP:0100626)	2.23799018
47	Abnormality of abdominal situs (HP:0011620)	2.20625002
48	Abdominal situs inversus (HP:0003363)	2.20625002
49	Partial agenesis of the corpus callosum (HP:0001338)	2.19985750
50	Abnormality of renal excretion (HP:0011036)	2.18385567
51	Muscle fibrillation (HP:0010546)	2.15753266
52	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.14967227
53	Hypoplasia of the fovea (HP:0007750)	2.14967227
54	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.13011863
55	Mask-like facies (HP:0000298)	2.10675098
56	Increased neuronal autofluorescent lipopigment (HP:0002074)	2.09647688
57	Upper limb muscle weakness (HP:0003484)	2.06030057
58	Abnormal umbilical cord blood vessels (HP:0011403)	1.98937618
59	Single umbilical artery (HP:0001195)	1.98937618
60	Abnormality of the fetal cardiovascular system (HP:0010948)	1.98937618
61	Hypoproteinemia (HP:0003075)	1.94220735
62	Hypoplastic iliac wings (HP:0002866)	1.93719992
63	Abnormality of the frontal sinuses (HP:0002687)	1.92374426
64	Erythroderma (HP:0001019)	1.90587456
65	Abolished electroretinogram (ERG) (HP:0000550)	1.90333326
66	Supernumerary bones of the axial skeleton (HP:0009144)	1.88855308
67	Granulocytopenia (HP:0001913)	1.88278086
68	Vacuolated lymphocytes (HP:0001922)	1.87781962
69	Cystic liver disease (HP:0006706)	1.86462219
70	Recurrent fungal infections (HP:0002841)	1.85493645
71	Keratoconjunctivitis (HP:0001096)	1.83297322
72	Renal tubular dysfunction (HP:0000124)	1.79710551
73	Woolly hair (HP:0002224)	1.79112546
74	Long clavicles (HP:0000890)	1.78997247
75	High pitched voice (HP:0001620)	1.76749330
76	Large for gestational age (HP:0001520)	1.76474156
77	Sloping forehead (HP:0000340)	1.73972555
78	Progressive inability to walk (HP:0002505)	1.73965400
79	Chronic sinusitis (HP:0011109)	1.73224776
80	Abnormality of the parathyroid morphology (HP:0011766)	1.72984881
81	Abnormality of midbrain morphology (HP:0002418)	1.72615138
82	Molar tooth sign on MRI (HP:0002419)	1.72615138
83	Rib fusion (HP:0000902)	1.72217017
84	Abnormality of potassium homeostasis (HP:0011042)	1.72064732
85	High anterior hairline (HP:0009890)	1.69510903
86	Occipital encephalocele (HP:0002085)	1.67894434
87	Abnormal rod and cone electroretinograms (HP:0008323)	1.67801909
88	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	1.66861653
89	Increased serum lactate (HP:0002151)	1.66386254
90	Abnormality of eosinophils (HP:0001879)	1.65630476
91	Chondrocalcinosis (HP:0000934)	1.63558705
92	Papilledema (HP:0001085)	1.62863273
93	Increased cerebral lipofuscin (HP:0011813)	1.62637712
94	Gonadotropin excess (HP:0000837)	1.62309639
95	Abnormality of chromosome stability (HP:0003220)	1.61973260
96	Clubbing of toes (HP:0100760)	1.61552741
97	Congenital sensorineural hearing impairment (HP:0008527)	1.58895338
98	Breech presentation (HP:0001623)	1.58874106
99	Adrenal hypoplasia (HP:0000835)	1.58535413
100	Abnormality of Sharpey fibers (HP:0100685)	1.57900057

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	WNK4	8.38502118
2	STK39	8.04424191
3	OXSR1	5.93932980
4	STK24	3.80218601
5	BUB1	3.00043463
6	BMPR1B	2.95240648
7	STK38L	2.79337089
8	TAOK3	2.66701968
9	MAPKAPK5	2.00974964
10	TLK1	1.90323047
11	PLK2	1.89393952
12	TNIK	1.72515428
13	ACVR1B	1.53215046
14	GRK6	1.41086998
15	PINK1	1.39223797
16	MAP2K7	1.20948853
17	ADRBK2	1.16973722
18	CDK8	1.14843829
19	GRK1	1.11221232
20	MAP3K9	1.06566255
21	EPHB1	1.04524996
22	ZAK	0.94145454
23	EIF2AK3	0.91257650
24	RIPK4	0.90747416
25	MST4	0.89299301
26	VRK2	0.86429069
27	FES	0.84362937
28	PHKG2	0.82135411
29	PHKG1	0.82135411
30	TAF1	0.77304176
31	MAP3K6	0.75439816
32	SIK2	0.74156019
33	TGFBR1	0.66445247
34	GRK5	0.65434025
35	CSNK1G3	0.64052774
36	JAK3	0.64011041
37	PTK2B	0.60936259
38	FRK	0.59737884
39	TYRO3	0.57753303
40	ADRBK1	0.53736760
41	VRK1	0.51286728
42	MAP3K12	0.48195386
43	STK3	0.47705729
44	BMPR2	0.46772329
45	CDK9	0.45602907
46	NTRK3	0.44981673
47	CSNK1G2	0.44649629
48	MAP2K4	0.42627568
49	CAMKK2	0.40660211
50	TNK2	0.39347728
51	NUAK1	0.37735952
52	CSNK1G1	0.36983374
53	RPS6KA5	0.36116899
54	PRKCQ	0.35189582
55	LRRK2	0.33449152
56	SYK	0.33036257
57	WEE1	0.32976670
58	PIK3CG	0.31662011
59	MAP2K6	0.30537067
60	CAMK2A	0.29237493
61	PRKCE	0.28877583
62	NME1	0.28277536
63	SCYL2	0.27496598
64	ITK	0.27148717
65	PLK1	0.27083099
66	IKBKB	0.26977867
67	ZAP70	0.26781512
68	MAP3K4	0.25538689
69	ATM	0.25044030
70	ATR	0.24266492
71	BCKDK	0.23908199
72	CHEK2	0.23889450
73	NEK9	0.23758735
74	PRKCI	0.23599176
75	TRPM7	0.22895353
76	ERBB2	0.22536640
77	INSRR	0.22101324
78	DAPK2	0.21938841
79	PRKG2	0.21795095
80	MKNK2	0.20183901
81	CAMK2D	0.20067620
82	CSNK1D	0.19801641
83	MKNK1	0.19148526
84	RPS6KB2	0.18373498
85	MAP4K1	0.18105598
86	CSK	0.16034515
87	RPS6KB1	0.15069737
88	MAP2K1	0.13923647
89	PNCK	0.13345206
90	CAMK2B	0.13182657
91	LYN	0.13074054
92	PRKAA1	0.12489042
93	FLT3	0.12345185
94	NEK1	0.12259823
95	MAP3K11	0.11608236
96	EIF2AK2	0.10728266
97	MAP3K5	0.10566877
98	AURKB	0.10329815
99	PAK3	0.10312493
100	WNK3	0.10286526

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Vitamin B6 metabolism_Homo sapiens_hsa00750	5.46052191
2	Collecting duct acid secretion_Homo sapiens_hsa04966	5.09558925
3	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.97256565
4	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	3.35171050
5	Primary immunodeficiency_Homo sapiens_hsa05340	2.88928543
6	Asthma_Homo sapiens_hsa05310	2.57569311
7	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.19685377
8	Basal transcription factors_Homo sapiens_hsa03022	2.14986558
9	Rheumatoid arthritis_Homo sapiens_hsa05323	2.04236418
10	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	2.03473799
11	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.02597615
12	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.00081286
13	Base excision repair_Homo sapiens_hsa03410	1.98134154
14	Nucleotide excision repair_Homo sapiens_hsa03420	1.90273268
15	DNA replication_Homo sapiens_hsa03030	1.85541436
16	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.81210213
17	Allograft rejection_Homo sapiens_hsa05330	1.72257127
18	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.70081318
19	Cocaine addiction_Homo sapiens_hsa05030	1.63907182
20	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.61355013
21	Graft-versus-host disease_Homo sapiens_hsa05332	1.60659757
22	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.59418688
23	Oxidative phosphorylation_Homo sapiens_hsa00190	1.58109845
24	Sulfur metabolism_Homo sapiens_hsa00920	1.52321894
25	Ether lipid metabolism_Homo sapiens_hsa00565	1.44522254
26	Other glycan degradation_Homo sapiens_hsa00511	1.35534186
27	Nitrogen metabolism_Homo sapiens_hsa00910	1.33513001
28	RNA degradation_Homo sapiens_hsa03018	1.31668567
29	Olfactory transduction_Homo sapiens_hsa04740	1.31297970
30	Linoleic acid metabolism_Homo sapiens_hsa00591	1.30053508
31	Selenocompound metabolism_Homo sapiens_hsa00450	1.27843193
32	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.27149824
33	Vibrio cholerae infection_Homo sapiens_hsa05110	1.24408741
34	Type I diabetes mellitus_Homo sapiens_hsa04940	1.18686277
35	Parkinsons disease_Homo sapiens_hsa05012	1.17601622
36	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.12785671
37	Homologous recombination_Homo sapiens_hsa03440	1.11268666
38	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.09793051
39	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.07559268
40	RNA transport_Homo sapiens_hsa03013	1.04194361
41	Tyrosine metabolism_Homo sapiens_hsa00350	0.98272986
42	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.97588888
43	Non-homologous end-joining_Homo sapiens_hsa03450	0.93480508
44	Protein export_Homo sapiens_hsa03060	0.89796008
45	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.87415495
46	Fanconi anemia pathway_Homo sapiens_hsa03460	0.86303124
47	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.86208008
48	Mismatch repair_Homo sapiens_hsa03430	0.85438964
49	One carbon pool by folate_Homo sapiens_hsa00670	0.82018283
50	Steroid biosynthesis_Homo sapiens_hsa00100	0.80901737
51	Peroxisome_Homo sapiens_hsa04146	0.80093208
52	Alcoholism_Homo sapiens_hsa05034	0.79019781
53	Folate biosynthesis_Homo sapiens_hsa00790	0.78734553
54	Viral myocarditis_Homo sapiens_hsa05416	0.78452055
55	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.73138821
56	Caffeine metabolism_Homo sapiens_hsa00232	0.72728917
57	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.71259282
58	Phagosome_Homo sapiens_hsa04145	0.69779962
59	Ribosome_Homo sapiens_hsa03010	0.67636479
60	Tuberculosis_Homo sapiens_hsa05152	0.65299938
61	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.63907533
62	Amphetamine addiction_Homo sapiens_hsa05031	0.62797070
63	Herpes simplex infection_Homo sapiens_hsa05168	0.61389235
64	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.61056103
65	Proteasome_Homo sapiens_hsa03050	0.57997219
66	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.53542024
67	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.49120281
68	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.46546933
69	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.46341078
70	Lysosome_Homo sapiens_hsa04142	0.45050678
71	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.39893244
72	Viral carcinogenesis_Homo sapiens_hsa05203	0.38655277
73	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.38304344
74	Pyrimidine metabolism_Homo sapiens_hsa00240	0.37754012
75	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.37078589
76	Renin-angiotensin system_Homo sapiens_hsa04614	0.36600010
77	Serotonergic synapse_Homo sapiens_hsa04726	0.36509863
78	Alzheimers disease_Homo sapiens_hsa05010	0.36329915
79	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.35664744
80	Antigen processing and presentation_Homo sapiens_hsa04612	0.35548715
81	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.33251617
82	Influenza A_Homo sapiens_hsa05164	0.29340160
83	Metabolic pathways_Homo sapiens_hsa01100	0.29187733
84	Nicotine addiction_Homo sapiens_hsa05033	0.28206803
85	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.27491690
86	Tryptophan metabolism_Homo sapiens_hsa00380	0.26341797
87	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.26332109
88	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.25812822
89	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.24682524
90	p53 signaling pathway_Homo sapiens_hsa04115	0.24173449
91	Purine metabolism_Homo sapiens_hsa00230	0.22184831
92	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.20356445
93	Dopaminergic synapse_Homo sapiens_hsa04728	0.19379491
94	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.18884711
95	mRNA surveillance pathway_Homo sapiens_hsa03015	0.18460198
96	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.14986732
97	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.14950981
98	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.14117369
99	Taste transduction_Homo sapiens_hsa04742	0.13232305
100	Butanoate metabolism_Homo sapiens_hsa00650	0.12038699

DPRXP3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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