DPY19L1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)8.76484877
2myelination (GO:0042552)6.81220398
3ensheathment of neurons (GO:0007272)6.80839377
4axon ensheathment (GO:0008366)6.80839377
5long-chain fatty acid biosynthetic process (GO:0042759)6.42748283
6myelin maintenance (GO:0043217)6.19719596
7response to methylmercury (GO:0051597)5.85407224
8L-amino acid import (GO:0043092)5.70877559
9negative regulation of neurotransmitter transport (GO:0051589)5.42257587
10cholesterol biosynthetic process (GO:0006695)5.24467647
11negative regulation of neurotransmitter secretion (GO:0046929)5.00035853
12establishment of mitochondrion localization (GO:0051654)4.97707338
13amyloid precursor protein metabolic process (GO:0042982)4.96223322
14sterol biosynthetic process (GO:0016126)4.77405729
15cell adhesion mediated by integrin (GO:0033627)4.74040686
16long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.70717308
17negative regulation of protein localization to cell surface (GO:2000009)4.70586963
18nuclear pore complex assembly (GO:0051292)4.68310556
19regulation of collateral sprouting (GO:0048670)4.52681951
20regulation of lipoprotein metabolic process (GO:0050746)4.36009020
21import into cell (GO:0098657)4.28653823
22long-chain fatty-acyl-CoA metabolic process (GO:0035336)4.28258943
23glycerophospholipid catabolic process (GO:0046475)4.24400587
24positive regulation of oligodendrocyte differentiation (GO:0048714)4.23289057
25nuclear pore organization (GO:0006999)4.17231949
26presynaptic membrane organization (GO:0097090)4.15231695
27astrocyte development (GO:0014002)4.15208953
28fatty-acyl-CoA biosynthetic process (GO:0046949)4.14515381
29isoprenoid biosynthetic process (GO:0008299)4.04200390
30amino acid import (GO:0043090)4.04005033
31Golgi transport vesicle coating (GO:0048200)3.96912108
32COPI coating of Golgi vesicle (GO:0048205)3.96912108
33apical protein localization (GO:0045176)3.96572244
34asymmetric protein localization (GO:0008105)3.96203562
35creatine metabolic process (GO:0006600)3.90671495
36eye photoreceptor cell differentiation (GO:0001754)3.90082244
37photoreceptor cell differentiation (GO:0046530)3.90082244
38neurotransmitter uptake (GO:0001504)3.86782794
39membrane tubulation (GO:0097320)3.85065352
40oligodendrocyte differentiation (GO:0048709)3.84029090
41very long-chain fatty acid metabolic process (GO:0000038)3.79420901
42response to lipoprotein particle (GO:0055094)3.75624114
43fatty-acyl-CoA metabolic process (GO:0035337)3.74569667
44mitotic chromosome condensation (GO:0007076)3.73844547
45maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.64278578
46mesodermal cell differentiation (GO:0048333)3.61301186
47protein retention in ER lumen (GO:0006621)3.56868504
48paraxial mesoderm development (GO:0048339)3.56778292
49erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.52629647
50L-phenylalanine catabolic process (GO:0006559)3.52629647
51negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.51710270
52presynaptic membrane assembly (GO:0097105)3.50764085
53cerebral cortex radially oriented cell migration (GO:0021799)3.46371004
54hemidesmosome assembly (GO:0031581)3.43305670
55cytoskeletal anchoring at plasma membrane (GO:0007016)3.43079154
56magnesium ion transport (GO:0015693)3.37964053
57limb bud formation (GO:0060174)3.36482602
58negative regulation of chondrocyte differentiation (GO:0032331)3.33331312
59amyloid precursor protein catabolic process (GO:0042987)3.31327935
60retina vasculature morphogenesis in camera-type eye (GO:0061299)3.30012897
61organ growth (GO:0035265)3.29060076
62pore complex assembly (GO:0046931)3.26663530
63peripheral nervous system axon ensheathment (GO:0032292)3.24656555
64myelination in peripheral nervous system (GO:0022011)3.24656555
65substantia nigra development (GO:0021762)3.22181651
66DNA unwinding involved in DNA replication (GO:0006268)3.21774743
67protein palmitoylation (GO:0018345)3.20963174
68heme transport (GO:0015886)3.20136972
69axon development (GO:0061564)3.19268244
70skin morphogenesis (GO:0043589)3.16940993
71adult walking behavior (GO:0007628)3.15802824
72acyl-CoA biosynthetic process (GO:0071616)3.14778871
73thioester biosynthetic process (GO:0035384)3.14778871
74nerve growth factor signaling pathway (GO:0038180)3.12053257
75negative regulation of Rho protein signal transduction (GO:0035024)3.11871722
76endothelial cell morphogenesis (GO:0001886)3.08740505
77positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)3.08390338
78mitotic sister chromatid cohesion (GO:0007064)3.04988966
79response to lead ion (GO:0010288)3.03437715
80cellular protein complex localization (GO:0034629)3.02671018
81neuron remodeling (GO:0016322)3.02216139
82protein localization to endosome (GO:0036010)3.02015476
83regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.98058571
84iron coordination entity transport (GO:1901678)2.98009475
85notochord development (GO:0030903)2.95468680
86dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.94194598
87response to redox state (GO:0051775)2.93679806
88negative regulation of axonogenesis (GO:0050771)2.92900171
89cell-substrate junction assembly (GO:0007044)2.92353441
90regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.92155409
91protein hydroxylation (GO:0018126)2.91647191
92detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.89457103
93detection of temperature stimulus involved in sensory perception (GO:0050961)2.89457103
94GPI anchor biosynthetic process (GO:0006506)2.87163883
95extracellular matrix assembly (GO:0085029)2.87093938
96C4-dicarboxylate transport (GO:0015740)2.86706947
97endodermal cell differentiation (GO:0035987)2.86003361
98glycosylceramide metabolic process (GO:0006677)2.85974174
99positive regulation of osteoblast proliferation (GO:0033690)2.85953830
100lateral sprouting from an epithelium (GO:0060601)2.85071493
101L-glutamate transport (GO:0015813)2.84737525
102hippo signaling (GO:0035329)2.84584053
103GPI anchor metabolic process (GO:0006505)2.84558550
104neuronal action potential propagation (GO:0019227)2.82554459
105Golgi to endosome transport (GO:0006895)2.80479884
106wound healing, spreading of epidermal cells (GO:0035313)2.78112545
107hypotonic response (GO:0006971)2.77848535
108erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.77537410
109L-phenylalanine metabolic process (GO:0006558)2.77537410
110acidic amino acid transport (GO:0015800)2.77137445
111preassembly of GPI anchor in ER membrane (GO:0016254)2.72208479
112enteric nervous system development (GO:0048484)2.72030594
113regulation of mitotic spindle organization (GO:0060236)2.71925367
114epithelial cell-cell adhesion (GO:0090136)2.71387538
115peptidyl-tyrosine autophosphorylation (GO:0038083)2.69384310
116peptidyl-proline hydroxylation (GO:0019511)2.68773298
117peripheral nervous system development (GO:0007422)2.68563932
118microtubule polymerization or depolymerization (GO:0031109)2.68230789
119mechanosensory behavior (GO:0007638)2.66696835
120chondrocyte proliferation (GO:0035988)2.66136672
121mesenchymal-epithelial cell signaling (GO:0060638)2.65359236
122negative regulation of macroautophagy (GO:0016242)2.63668737
123regulation of transforming growth factor beta2 production (GO:0032909)2.62628708
124substrate-dependent cell migration (GO:0006929)2.62375524
125positive regulation of catenin import into nucleus (GO:0035413)2.62213724
126mitotic cytokinesis (GO:0000281)2.61622807
127protein neddylation (GO:0045116)2.60870086
128semaphorin-plexin signaling pathway (GO:0071526)2.60530738
129apoptotic cell clearance (GO:0043277)2.60194632
130regulation of early endosome to late endosome transport (GO:2000641)2.60154915
131planar cell polarity pathway involved in neural tube closure (GO:0090179)2.59967714
132neuron cell-cell adhesion (GO:0007158)2.59773873
133substrate-independent telencephalic tangential migration (GO:0021826)2.58913101
134substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.58913101
135adherens junction assembly (GO:0034333)2.58030568
136morphogenesis of an epithelial sheet (GO:0002011)2.57907062
137positive regulation of glial cell differentiation (GO:0045687)2.56749531
138neuron projection extension involved in neuron projection guidance (GO:1902284)2.56383807
139axon extension involved in axon guidance (GO:0048846)2.56383807
140mitotic metaphase plate congression (GO:0007080)2.55973651
141chondrocyte development (GO:0002063)2.55695648
142cellular response to vitamin D (GO:0071305)2.55088057
143cholesterol metabolic process (GO:0008203)2.53416266
144tissue regeneration (GO:0042246)2.51841619
145regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.51413695
146cytoskeleton-dependent cytokinesis (GO:0061640)2.51407364
147positive regulation of adherens junction organization (GO:1903393)2.51313061
148chromosome condensation (GO:0030261)2.50327567
149embryonic foregut morphogenesis (GO:0048617)2.50241443
150negative regulation of execution phase of apoptosis (GO:1900118)2.49706600
151neuron recognition (GO:0008038)2.49671711
152positive regulation of gliogenesis (GO:0014015)2.49610339
153vesicle coating (GO:0006901)2.48555437
154SMAD protein complex assembly (GO:0007183)2.46501476
155regulation of pigment cell differentiation (GO:0050932)2.46498741
156positive regulation of DNA-dependent DNA replication (GO:2000105)2.46344488
157regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.46218168
158positive regulation of focal adhesion assembly (GO:0051894)2.45789368
159positive regulation of cell junction assembly (GO:1901890)2.45789368
160collagen fibril organization (GO:0030199)2.44375877
161craniofacial suture morphogenesis (GO:0097094)2.43410058
162sister chromatid segregation (GO:0000819)2.43324150
163regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.43076935
164Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.43067289
165muscle cell migration (GO:0014812)2.43024255
166negative regulation of anoikis (GO:2000811)2.42958082
167membrane protein ectodomain proteolysis (GO:0006509)2.42841937
168substrate adhesion-dependent cell spreading (GO:0034446)2.40202639
169cell migration involved in sprouting angiogenesis (GO:0002042)2.39671691
170gonadal mesoderm development (GO:0007506)2.38754491
171retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.38540329
172regulation of axon extension involved in axon guidance (GO:0048841)2.38265357
173embryonic retina morphogenesis in camera-type eye (GO:0060059)2.38001655
174protein localization to microtubule (GO:0035372)2.37378154
175hepatocyte differentiation (GO:0070365)2.36972561
176wound healing, spreading of cells (GO:0044319)2.36339656
177positive regulation of cell size (GO:0045793)2.36029323
178regulation of establishment of planar polarity (GO:0090175)2.35432801
179mitotic sister chromatid segregation (GO:0000070)2.34733089
180protein localization to chromosome, centromeric region (GO:0071459)2.34601641
181focal adhesion assembly (GO:0048041)2.33984195
182cell-substrate adherens junction assembly (GO:0007045)2.33984195
183protein complex localization (GO:0031503)2.33903569
184regulation of translational fidelity (GO:0006450)2.33425580
185gap junction assembly (GO:0016264)2.32363651
186regulation of cardioblast differentiation (GO:0051890)2.31089837
187glomerular visceral epithelial cell development (GO:0072015)2.29837127
188regulation of sister chromatid cohesion (GO:0007063)2.28574644
189regulation of glucose import in response to insulin stimulus (GO:2001273)2.25192514
190regulation of catenin import into nucleus (GO:0035412)2.24105747
191camera-type eye morphogenesis (GO:0048593)2.23799230
192basement membrane organization (GO:0071711)2.22833950
193vascular endothelial growth factor signaling pathway (GO:0038084)2.22752424
194regulation of glomerular filtration (GO:0003093)2.20325822
195central nervous system myelination (GO:0022010)12.8060004
196axon ensheathment in central nervous system (GO:0032291)12.8060004

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.75192329
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.25077850
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.91648273
4GBX2_23144817_ChIP-Seq_PC3_Human3.58798171
5AR_21909140_ChIP-Seq_LNCAP_Human3.50577174
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.18560863
7* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse3.09994454
8EZH2_22144423_ChIP-Seq_EOC_Human2.90457779
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.87858118
10SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.74581199
11TAF15_26573619_Chip-Seq_HEK293_Human2.73049450
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.61802808
13TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.56139116
14* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.55220606
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.49352363
16TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.39901814
17CLOCK_20551151_ChIP-Seq_293T_Human2.38192685
18AR_21572438_ChIP-Seq_LNCaP_Human2.28094759
19* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.26916597
20PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.15469016
21WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.13451900
22SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.11621917
23VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.09722210
24SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.08113232
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.07596258
26SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.02072255
27* ER_23166858_ChIP-Seq_MCF-7_Human2.00842455
28RBPJ_22232070_ChIP-Seq_NCS_Mouse1.97912156
29JARID2_20064375_ChIP-Seq_MESCs_Mouse1.95714115
30KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.91472953
31POU3F2_20337985_ChIP-ChIP_501MEL_Human1.91054304
32RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.90009180
33SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.83977438
34FUS_26573619_Chip-Seq_HEK293_Human1.83355923
35KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.80236547
36SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.78214596
37SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.78214596
38BRD4_25478319_ChIP-Seq_HGPS_Human1.77961989
39MTF2_20144788_ChIP-Seq_MESCs_Mouse1.76394273
40SALL4_18804426_ChIP-ChIP_XEN_Mouse1.75896019
41WT1_19549856_ChIP-ChIP_CCG9911_Human1.73411931
42SMAD3_21741376_ChIP-Seq_EPCs_Human1.72648979
43TP53_16413492_ChIP-PET_HCT116_Human1.72436013
44RARG_19884340_ChIP-ChIP_MEFs_Mouse1.72264841
45SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.72250232
46VDR_22108803_ChIP-Seq_LS180_Human1.71415466
47ZNF263_19887448_ChIP-Seq_K562_Human1.71333660
48P300_27058665_Chip-Seq_ZR-75-30cells_Human1.71261297
49NRF2_20460467_ChIP-Seq_MEFs_Mouse1.71041849
50NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.71041849
51SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.70980760
52CTNNB1_20460455_ChIP-Seq_HCT116_Human1.69902717
53EED_16625203_ChIP-ChIP_MESCs_Mouse1.69153252
54CDX2_19796622_ChIP-Seq_MESCs_Mouse1.68263393
55EZH2_18974828_ChIP-Seq_MESCs_Mouse1.65855425
56RNF2_18974828_ChIP-Seq_MESCs_Mouse1.65855425
57SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.64126541
58POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.62819578
59STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.62421274
60CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.61470612
61* CJUN_26792858_Chip-Seq_BT549_Human1.61331426
62SALL1_21062744_ChIP-ChIP_HESCs_Human1.60745887
63P300_19829295_ChIP-Seq_ESCs_Human1.60715552
64SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.60514764
65PIAS1_25552417_ChIP-Seq_VCAP_Human1.58082198
66FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.57088689
67PPAR_26484153_Chip-Seq_NCI-H1993_Human1.56086865
68CTBP1_25329375_ChIP-Seq_LNCAP_Human1.55130194
69DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.53535777
70CTBP2_25329375_ChIP-Seq_LNCAP_Human1.53484018
71NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.51179811
72MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.49867957
73RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.48891726
74SOX9_24532713_ChIP-Seq_HFSC_Mouse1.45175448
75* EZH2_27304074_Chip-Seq_ESCs_Mouse1.45134718
76PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44199744
77TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44174178
78AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.43105237
79PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.40817049
80ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.38731443
81STAT3_23295773_ChIP-Seq_U87_Human1.38640977
82* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.38428745
83HIF1A_21447827_ChIP-Seq_MCF-7_Human1.38347611
84RNF2_27304074_Chip-Seq_ESCs_Mouse1.35828242
85GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35546757
86LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35177256
87TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34365048
88PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.34303022
89SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33787892
90CMYC_18555785_Chip-Seq_ESCs_Mouse1.33293551
91CBX2_27304074_Chip-Seq_ESCs_Mouse1.32027715
92JARID2_20075857_ChIP-Seq_MESCs_Mouse1.32027292
93KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.31658045
94ZFX_18555785_ChIP-Seq_MESCs_Mouse1.30582093
95EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.30300336
96SMAD_19615063_ChIP-ChIP_OVARY_Human1.30071865
97SUZ12_27294783_Chip-Seq_ESCs_Mouse1.28489881
98EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.27890548
99EWS_26573619_Chip-Seq_HEK293_Human1.27887798
100NANOG_18555785_Chip-Seq_ESCs_Mouse1.27554136
101EZH2_27294783_Chip-Seq_ESCs_Mouse1.27477203
102E2F4_17652178_ChIP-ChIP_JURKAT_Human1.26911046
103GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.25918982
104UBF1/2_26484160_Chip-Seq_HMECs_Human1.25745353
105PRDM14_20953172_ChIP-Seq_ESCs_Human1.25178485
106TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23912551
107TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23278889
108TAL1_26923725_Chip-Seq_HPCs_Mouse1.21823359
109SMAD4_21799915_ChIP-Seq_A2780_Human1.21691245
110* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.21326874
111UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20627087
112SUZ12_18555785_Chip-Seq_ESCs_Mouse1.19855697
113NFIB_24661679_ChIP-Seq_LUNG_Mouse1.19747802
114TCF4_23295773_ChIP-Seq_U87_Human1.19563090
115HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.19525702
116SOX17_20123909_ChIP-Seq_XEN_Mouse1.19294030
117TP53_18474530_ChIP-ChIP_U2OS_Human1.19222299
118EP300_21415370_ChIP-Seq_HL-1_Mouse1.19140840
119FOXO3_23340844_ChIP-Seq_DLD1_Human1.18801947
120E2F1_21310950_ChIP-Seq_MCF-7_Human1.17956662
121TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17835880
122KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17261150
123ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.16109087
124ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.16003989
125MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15869587
126EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.15759489
127P300_18555785_Chip-Seq_ESCs_Mouse1.15595333
128NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.14809448
129HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.14064738
130NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13445775
131HTT_18923047_ChIP-ChIP_STHdh_Human1.13195462
132RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.12623082
133CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.11848207
134ATF3_27146783_Chip-Seq_COLON_Human1.11493063
135* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.10848688
136EOMES_21245162_ChIP-Seq_HESCs_Human1.10825286
137EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10300691
138SMAD4_21741376_ChIP-Seq_EPCs_Human1.09801464
139KDM2B_26808549_Chip-Seq_K562_Human1.09697685
140SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.09255384
141DROSHA_22980978_ChIP-Seq_HELA_Human1.09230544
142TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.08718550
143ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.08334667
144E2F1_18555785_Chip-Seq_ESCs_Mouse1.06366307
145PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.05937608
146FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.04131004
147TBX20_22328084_ChIP-Seq_HEART_Mouse1.04061791
148TBX20_22080862_ChIP-Seq_HEART_Mouse1.04061791
149CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.03837655
150* RARB_27405468_Chip-Seq_BRAIN_Mouse1.03449307
151SOX2_27498859_Chip-Seq_STOMACH_Mouse1.03303593
152ELK3_25401928_ChIP-Seq_HUVEC_Human1.03055285
153FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.02216298
154MYC_18555785_ChIP-Seq_MESCs_Mouse1.01900389
155IGF1R_20145208_ChIP-Seq_DFB_Human1.01875258
156TCF4_18268006_ChIP-ChIP_LS174T_Human1.01768307
157P53_22387025_ChIP-Seq_ESCs_Mouse1.01681635
158TRIM28_21343339_ChIP-Seq_HEK293_Human1.01401129
159EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.00747333
160TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00467201
161WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00384678
162ISL1_27105846_Chip-Seq_CPCs_Mouse1.00369305
163NANOG_19829295_ChIP-Seq_ESCs_Human1.00335997
164SOX2_19829295_ChIP-Seq_ESCs_Human1.00335997
165PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.00170618
166JUN_21703547_ChIP-Seq_K562_Human1.00002862
167* ARNT_22903824_ChIP-Seq_MCF-7_Human0.99614809
168DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.99329013
169NANOG_21062744_ChIP-ChIP_HESCs_Human0.98905137
170TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98636582
171ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98481575
172* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.97550775
173LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97275587
174MYCN_18555785_ChIP-Seq_MESCs_Mouse0.97230593
175ZFP281_27345836_Chip-Seq_ESCs_Mouse0.96936192
176EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96740942
177GATA2_21666600_ChIP-Seq_HMVEC_Human0.95674316
178ESR2_21235772_ChIP-Seq_MCF-7_Human0.95508989
179RUNX2_22187159_ChIP-Seq_PCA_Human0.94770984
180* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.93547578
181MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.92063673
182FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.91243654
183EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.90745410
184NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.90233258
185GATA4_21415370_ChIP-Seq_HL-1_Mouse0.89293931
186TCF3_18692474_ChIP-Seq_MEFs_Mouse0.88013612
187RING1B_27294783_Chip-Seq_NPCs_Mouse0.86772559

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination5.68261023
2MP0003950_abnormal_plasma_membrane4.37169004
3MP0003880_abnormal_central_pattern3.82360276
4MP0003329_amyloid_beta_deposits3.80038301
5MP0003705_abnormal_hypodermis_morpholog3.42561063
6MP0003690_abnormal_glial_cell3.38335471
7MP0002877_abnormal_melanocyte_morpholog3.35459497
8MP0005171_absent_coat_pigmentation3.32962529
9MP0004270_analgesia2.97506942
10MP0003566_abnormal_cell_adhesion2.88429597
11MP0010368_abnormal_lymphatic_system2.83210991
12MP0003136_yellow_coat_color2.76572066
13MP0010352_gastrointestinal_tract_polyps2.74221349
14MP0005257_abnormal_intraocular_pressure2.60505745
15MP0001529_abnormal_vocalization2.46133986
16MP0010030_abnormal_orbit_morphology2.43982099
17MP0003632_abnormal_nervous_system2.33492793
18MP0001486_abnormal_startle_reflex2.30252333
19MP0000537_abnormal_urethra_morphology2.28931217
20MP0002272_abnormal_nervous_system2.27061695
21MP0008438_abnormal_cutaneous_collagen2.25698157
22MP0005410_abnormal_fertilization2.25341360
23MP0000604_amyloidosis2.21061058
24MP0003634_abnormal_glial_cell2.21035398
25MP0004885_abnormal_endolymph2.20532963
26MP0004742_abnormal_vestibular_system2.16544810
27MP0009053_abnormal_anal_canal2.14013800
28MP0002064_seizures2.11743574
29MP0005409_darkened_coat_color2.11664307
30MP0001905_abnormal_dopamine_level2.08405617
31MP0005623_abnormal_meninges_morphology2.08042673
32MP0000778_abnormal_nervous_system2.05091405
33MP0003806_abnormal_nucleotide_metabolis2.01152569
34MP0004142_abnormal_muscle_tone2.01106336
35MP0003091_abnormal_cell_migration1.99609720
36MP0010678_abnormal_skin_adnexa1.94761725
37MP0003631_nervous_system_phenotype1.89457956
38MP0005423_abnormal_somatic_nervous1.88917258
39MP0004134_abnormal_chest_morphology1.87052672
40MP0004233_abnormal_muscle_weight1.81914139
41MP0004859_abnormal_synaptic_plasticity1.80658965
42MP0001879_abnormal_lymphatic_vessel1.79660893
43MP0009780_abnormal_chondrocyte_physiolo1.79533310
44MP0001485_abnormal_pinna_reflex1.77621042
45MP0005076_abnormal_cell_differentiation1.77198502
46MP0003633_abnormal_nervous_system1.66518347
47MP0000428_abnormal_craniofacial_morphol1.65456435
48MP0003635_abnormal_synaptic_transmissio1.63254515
49MP0002139_abnormal_hepatobiliary_system1.61521090
50MP0002229_neurodegeneration1.60716230
51MP0010234_abnormal_vibrissa_follicle1.59985131
52MP0003385_abnormal_body_wall1.58120893
53MP0009745_abnormal_behavioral_response1.56287157
54MP0002697_abnormal_eye_size1.51709012
55MP0001915_intracranial_hemorrhage1.51094748
56MP0001849_ear_inflammation1.47915659
57MP0003941_abnormal_skin_development1.47627570
58MP0000733_abnormal_muscle_development1.46020525
59MP0000534_abnormal_ureter_morphology1.44588608
60MP0000383_abnormal_hair_follicle1.42833130
61MP0005451_abnormal_body_composition1.40691036
62MP0004043_abnormal_pH_regulation1.39320480
63MP0005023_abnormal_wound_healing1.38063831
64MP0009046_muscle_twitch1.37514298
65MP0009697_abnormal_copulation1.36346364
66MP0003656_abnormal_erythrocyte_physiolo1.34712678
67MP0003195_calcinosis1.33683154
68MP0005197_abnormal_uvea_morphology1.33414711
69MP0004858_abnormal_nervous_system1.33321559
70MP0000566_synostosis1.33302285
71MP0000955_abnormal_spinal_cord1.32430643
72MP0003279_aneurysm1.30840554
73MP0002084_abnormal_developmental_patter1.30286511
74MP0006054_spinal_hemorrhage1.29949614
75MP0002896_abnormal_bone_mineralization1.29060119
76MP0005275_abnormal_skin_tensile1.28965785
77MP0004957_abnormal_blastocyst_morpholog1.27271717
78MP0002233_abnormal_nose_morphology1.26377913
79MP0003283_abnormal_digestive_organ1.26319536
80MP0001177_atelectasis1.25994970
81MP0002572_abnormal_emotion/affect_behav1.25540274
82MP0002092_abnormal_eye_morphology1.25010488
83MP0002060_abnormal_skin_morphology1.23001511
84MP0001299_abnormal_eye_distance/1.22877157
85MP0002063_abnormal_learning/memory/cond1.22616558
86MP0002734_abnormal_mechanical_nocicepti1.22378291
87MP0000462_abnormal_digestive_system1.22131279
88MP0000767_abnormal_smooth_muscle1.21575552
89MP0004084_abnormal_cardiac_muscle1.21389186
90MP0003935_abnormal_craniofacial_develop1.18312198
91MP0002295_abnormal_pulmonary_circulatio1.17817085
92MP0002882_abnormal_neuron_morphology1.17378438
93MP0004381_abnormal_hair_follicle1.16022714
94MP0001958_emphysema1.15954339
95MP0000647_abnormal_sebaceous_gland1.15785546
96MP0004185_abnormal_adipocyte_glucose1.15568066
97MP0002086_abnormal_extraembryonic_tissu1.15527683
98MP0003937_abnormal_limbs/digits/tail_de1.15021097
99MP0005551_abnormal_eye_electrophysiolog1.14600638
100MP0002066_abnormal_motor_capabilities/c1.10921924
101MP0001672_abnormal_embryogenesis/_devel1.10724578
102MP0005380_embryogenesis_phenotype1.10724578
103MP0000432_abnormal_head_morphology1.10700117
104MP0003984_embryonic_growth_retardation1.10172787
105MP0005248_abnormal_Harderian_gland1.10160147
106MP0008569_lethality_at_weaning1.10047903
107MP0003942_abnormal_urinary_system1.08199855
108MP0008932_abnormal_embryonic_tissue1.07384921
109MP0001730_embryonic_growth_arrest1.06504984
110MP0005408_hypopigmentation1.05334464
111MP0000747_muscle_weakness1.04836648
112MP0002085_abnormal_embryonic_tissue1.03813733
113MP0001440_abnormal_grooming_behavior1.02943516
114MP0002088_abnormal_embryonic_growth/wei1.02911721
115MP0001963_abnormal_hearing_physiology1.01100294
116MP0003755_abnormal_palate_morphology0.98749407
117MP0001970_abnormal_pain_threshold0.97362853
118MP0003890_abnormal_embryonic-extraembry0.96243866
119MP0001697_abnormal_embryo_size0.95874612
120MP0002234_abnormal_pharynx_morphology0.95757832
121MP0002067_abnormal_sensory_capabilities0.94999795
122MP0001346_abnormal_lacrimal_gland0.94022896
123MP0008260_abnormal_autophagy0.93790199
124MP0006138_congestive_heart_failure0.93083083
125MP0003453_abnormal_keratinocyte_physiol0.93013189
126MP0002925_abnormal_cardiovascular_devel0.92974897
127MP0009250_abnormal_appendicular_skeleto0.92961910
128MP0005195_abnormal_posterior_eye0.92451078
129MP0002752_abnormal_somatic_nervous0.91059164
130MP0003115_abnormal_respiratory_system0.90595755
131MP0001286_abnormal_eye_development0.89701285
132MP0005386_behavior/neurological_phenoty0.89171763
133MP0004924_abnormal_behavior0.89171763
134MP0002080_prenatal_lethality0.88644158
135MP0000350_abnormal_cell_proliferation0.88479406
136MP0005621_abnormal_cell_physiology0.88206003
137MP0005508_abnormal_skeleton_morphology0.85581531
138MP0005388_respiratory_system_phenotype0.85401638
139MP0002133_abnormal_respiratory_system0.85401638
140MP0003938_abnormal_ear_development0.84586098
141MP0003077_abnormal_cell_cycle0.84096300
142MP0010307_abnormal_tumor_latency0.83598770
143MP0001348_abnormal_lacrimal_gland0.83114638
144MP0001614_abnormal_blood_vessel0.82622956
145MP0002152_abnormal_brain_morphology0.82141050
146MP0001661_extended_life_span0.81179725
147MP0000372_irregular_coat_pigmentation0.81100728
148MP0005503_abnormal_tendon_morphology0.79620416
149MP0001851_eye_inflammation0.79287772
150MP0003111_abnormal_nucleus_morphology0.78922379
151MP0002128_abnormal_blood_circulation0.77902460
152MP0010630_abnormal_cardiac_muscle0.77711602
153MP0001968_abnormal_touch/_nociception0.77617188
154MP0002089_abnormal_postnatal_growth/wei0.76545138
155MP0005193_abnormal_anterior_eye0.76500753
156MP0004147_increased_porphyrin_level0.75993804
157MP0001293_anophthalmia0.75757122
158MP0005058_abnormal_lysosome_morphology0.75033561
159MP0000751_myopathy0.74896894
160MP0008057_abnormal_DNA_replication0.74706487
161MP0002116_abnormal_craniofacial_bone0.74444250
162MP0004197_abnormal_fetal_growth/weight/0.73733572
163MP0005187_abnormal_penis_morphology0.72454290
164MP0000467_abnormal_esophagus_morphology0.72248947
165MP0003861_abnormal_nervous_system0.72075011
166MP0000762_abnormal_tongue_morphology0.71105273
167MP0006082_CNS_inflammation0.70425737
168MP0002736_abnormal_nociception_after0.69106550
169MP0004145_abnormal_muscle_electrophysio0.67812333
170MP0002733_abnormal_thermal_nociception0.66882075
171MP0009840_abnormal_foam_cell0.66643234
172MP0003191_abnormal_cellular_cholesterol0.66316287
173MP0000579_abnormal_nail_morphology0.65928826
174MP0004272_abnormal_basement_membrane0.63894786
175MP0001340_abnormal_eyelid_morphology0.62492904
176MP0002822_catalepsy0.61684338
177MP0000003_abnormal_adipose_tissue0.60284504
178MP0002090_abnormal_vision0.60016666
179MP0002108_abnormal_muscle_morphology0.59728038
180MP0001943_abnormal_respiration0.59702731
181MP0000639_abnormal_adrenal_gland0.58788426

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)7.43132882
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)7.43132882
3Neurofibrillary tangles (HP:0002185)6.71830380
4Abnormality of the corticospinal tract (HP:0002492)5.50497789
5Cerebral inclusion bodies (HP:0100314)5.15786071
6Parakeratosis (HP:0001036)5.06381992
7Termporal pattern (HP:0011008)4.89055567
8Insidious onset (HP:0003587)4.89055567
9Protrusio acetabuli (HP:0003179)4.31515479
10Peripheral hypomyelination (HP:0007182)4.01223827
11Arterial tortuosity (HP:0005116)3.89029991
12Abnormal auditory evoked potentials (HP:0006958)3.86128698
13Onion bulb formation (HP:0003383)3.65022228
14Vascular tortuosity (HP:0004948)3.56774695
15Spastic gait (HP:0002064)3.55639318
16Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.49068961
17Sensory axonal neuropathy (HP:0003390)3.48753533
18Supranuclear gaze palsy (HP:0000605)3.46714910
19Abnormality of the phalanges of the 2nd finger (HP:0009541)3.21696491
20Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.20285313
21Anteriorly placed anus (HP:0001545)3.16475081
22Ankyloglossia (HP:0010296)3.15927212
23Alacrima (HP:0000522)3.11396353
24Cerebral hypomyelination (HP:0006808)3.05626059
25Osteolytic defects of the hand bones (HP:0009699)3.03815478
26Osteolytic defects of the phalanges of the hand (HP:0009771)3.03815478
27Coronal craniosynostosis (HP:0004440)3.03222040
28Aortic dissection (HP:0002647)2.92696846
29Intention tremor (HP:0002080)2.91007309
30Insomnia (HP:0100785)2.89900491
31Dysmetria (HP:0001310)2.87733457
32Abnormality of oral frenula (HP:0000190)2.86136462
33Atrophic scars (HP:0001075)2.83260306
34Scanning speech (HP:0002168)2.81472869
35Ankle clonus (HP:0011448)2.81307004
36Aplasia involving bones of the upper limbs (HP:0009823)2.75175815
37Aplasia of the phalanges of the hand (HP:0009802)2.75175815
38Aplasia involving bones of the extremities (HP:0009825)2.75175815
39Retinal dysplasia (HP:0007973)2.70761987
40Shallow orbits (HP:0000586)2.67329147
41Clumsiness (HP:0002312)2.67088490
42Segmental peripheral demyelination/remyelination (HP:0003481)2.64264953
43Hyperacusis (HP:0010780)2.63574005
44Vertebral arch anomaly (HP:0008438)2.59530192
45Missing ribs (HP:0000921)2.56376307
46Increased serum pyruvate (HP:0003542)2.56112001
47Abnormality of glycolysis (HP:0004366)2.56112001
48Stridor (HP:0010307)2.56061746
49Bladder diverticulum (HP:0000015)2.53969286
50Fragile skin (HP:0001030)2.53804361
51Wormian bones (HP:0002645)2.53541397
52Hypoplastic pelvis (HP:0008839)2.51381994
53Leukodystrophy (HP:0002415)2.49846237
54Short nail (HP:0001799)2.48200405
55Ulnar bowing (HP:0003031)2.47809911
56Decreased lacrimation (HP:0000633)2.44324799
57Congenital ichthyosiform erythroderma (HP:0007431)2.43065650
58Slow saccadic eye movements (HP:0000514)2.41234867
59Lower limb muscle weakness (HP:0007340)2.40703447
60Infantile muscular hypotonia (HP:0008947)2.40581379
61Cerebral hemorrhage (HP:0001342)2.40532534
62Absent septum pellucidum (HP:0001331)2.38575530
63Vertebral compression fractures (HP:0002953)2.38288883
64Axonal loss (HP:0003447)2.37139973
65Ankle contracture (HP:0006466)2.36766992
66Autoamputation (HP:0001218)2.36035681
67Thickened helices (HP:0000391)2.34324633
68Spastic tetraparesis (HP:0001285)2.32772286
69Cerebral aneurysm (HP:0004944)2.31778307
70Humeroradial synostosis (HP:0003041)2.31604003
71Synostosis involving the elbow (HP:0003938)2.31604003
72Neonatal short-limb short stature (HP:0008921)2.30196793
73Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.27078415
74Vertebral hypoplasia (HP:0008417)2.27078415
75Hypophosphatemic rickets (HP:0004912)2.26965203
76Spinal rigidity (HP:0003306)2.24634162
77Mitral valve prolapse (HP:0001634)2.22233087
78Premature skin wrinkling (HP:0100678)2.19388976
79Urinary urgency (HP:0000012)2.19306367
80Esophageal atresia (HP:0002032)2.18866913
81Megalencephaly (HP:0001355)2.17471090
82White forelock (HP:0002211)2.15478061
83Soft skin (HP:0000977)2.15446291
84Abnormality of dentin (HP:0010299)2.15286286
85Action tremor (HP:0002345)2.13706358
86Renal duplication (HP:0000075)2.12345467
87Patchy hypopigmentation of hair (HP:0011365)2.09954367
88Arnold-Chiari malformation (HP:0002308)2.09755933
89Myokymia (HP:0002411)2.08351412
90CNS hypomyelination (HP:0003429)2.08224895
91Split foot (HP:0001839)2.07568860
92Absent frontal sinuses (HP:0002688)2.07342772
93Increased mean platelet volume (HP:0011877)2.07129381
94Aortic aneurysm (HP:0004942)2.07034951
95Buphthalmos (HP:0000557)2.05996368
96Increased nuchal translucency (HP:0010880)2.05931753
97Overriding aorta (HP:0002623)2.05871790
98Elfin facies (HP:0004428)2.05588309
99Hammertoe (HP:0001765)2.04918895
100Abnormality of aromatic amino acid family metabolism (HP:0004338)2.04437902
101Focal motor seizures (HP:0011153)2.02507125
102Mitral regurgitation (HP:0001653)2.01959576
103Subacute progressive viral hepatitis (HP:0006572)2.01840197
104Spastic paraparesis (HP:0002313)2.01217640
105Premature rupture of membranes (HP:0001788)2.01027909
106Morphological abnormality of the inner ear (HP:0011390)2.00499657
107Hypoplasia of the iris (HP:0007676)2.00385123
108Foot dorsiflexor weakness (HP:0009027)1.99927082
109Cervical subluxation (HP:0003308)1.99676225
110Abnormality of the middle phalanges of the toes (HP:0010183)1.99507955
111Pheochromocytoma (HP:0002666)1.99376430
112Abnormality of the 2nd finger (HP:0004100)1.99159300
113Clonus (HP:0002169)1.98760121
114Abnormality of the septum pellucidum (HP:0007375)1.98552949
115Morphological abnormality of the pyramidal tract (HP:0002062)1.97906716
116Abnormality of the distal phalanx of the thumb (HP:0009617)1.97825553
117Microglossia (HP:0000171)1.97729323
118Hepatosplenomegaly (HP:0001433)1.97593960
119Blue sclerae (HP:0000592)1.97460657
120Partial duplication of thumb phalanx (HP:0009944)1.94733470
121Abnormality of the acetabulum (HP:0003170)1.93855982
122Neuronal loss in central nervous system (HP:0002529)1.93440072
123Disproportionate tall stature (HP:0001519)1.92292251
124Mitral stenosis (HP:0001718)1.91460809
125Spastic paraplegia (HP:0001258)1.90695233
126Asymmetry of the thorax (HP:0001555)1.90448467
127Bell-shaped thorax (HP:0001591)1.90303535
128Flat acetabular roof (HP:0003180)1.89341797
129Abnormality of the distal phalanges of the toes (HP:0010182)1.88531563
130Decreased motor nerve conduction velocity (HP:0003431)1.87178416
131Spinal cord lesions (HP:0100561)1.86735936
132Syringomyelia (HP:0003396)1.86735936
133Bowel incontinence (HP:0002607)1.86099609
134Vertebral clefting (HP:0008428)1.85256709
135Selective tooth agenesis (HP:0001592)1.84900178
136Back pain (HP:0003418)1.84447653
137Relative macrocephaly (HP:0004482)1.83964821
138Bowel diverticulosis (HP:0005222)1.83927362
139Broad face (HP:0000283)1.83376067
140Urinary incontinence (HP:0000020)1.82653372
141Postnatal microcephaly (HP:0005484)1.82369739
142Metaphyseal dysplasia (HP:0100255)1.82142463
143Abnormality of the foot musculature (HP:0001436)1.80972397
144Hyperextensible skin (HP:0000974)1.79403277
145Cupped ear (HP:0000378)1.79055018
146Partial duplication of the phalanx of hand (HP:0009999)1.78324797
147Turricephaly (HP:0000262)1.77887606
148Urinary bladder sphincter dysfunction (HP:0002839)1.77352592
149Leiomyosarcoma (HP:0100243)1.77312949
150Uterine leiomyosarcoma (HP:0002891)1.77312949
151Natal tooth (HP:0000695)1.77198252
152Metabolic alkalosis (HP:0200114)1.76601400
153Renovascular hypertension (HP:0100817)1.75379626
154Diaphragmatic weakness (HP:0009113)1.75054577
155Stenosis of the external auditory canal (HP:0000402)1.73386444
156Paraplegia (HP:0010550)1.70864318
157Dilatation of the ascending aorta (HP:0005111)1.69940434
158Hemiparesis (HP:0001269)1.69784415
159Protruding ear (HP:0000411)1.69589084
160Deviation of the thumb (HP:0009603)1.68140611
161Peripheral demyelination (HP:0011096)1.67921348
162Abnormal large intestine physiology (HP:0012700)1.67910671
163Truncal ataxia (HP:0002078)1.67301192
164Prolonged neonatal jaundice (HP:0006579)1.66963669
165Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.66676707
166Broad metatarsal (HP:0001783)1.66400532
167Generalized myoclonic seizures (HP:0002123)1.65790745
168Delayed cranial suture closure (HP:0000270)1.64383639
169Neonatal death (HP:0003811)1.64100261
170Wide anterior fontanel (HP:0000260)1.64017072
171Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.63146594
172Overgrowth (HP:0001548)1.61938765
173Thoracolumbar scoliosis (HP:0002944)1.61691656
174Rhizomelia (HP:0008905)1.61200444
175Midface retrusion (HP:0011800)1.60118856
176Pulmonic stenosis (HP:0001642)1.59728648
177Abnormal delivery (HP:0001787)1.58956037
178Joint laxity (HP:0001388)1.58303399
179Abnormal platelet volume (HP:0011876)1.58076994
180Pterygium (HP:0001059)1.57943827
181Flat cornea (HP:0007720)1.57855224
182Mild short stature (HP:0003502)1.57349651
183Upper limb amyotrophy (HP:0009129)1.57165693
184Distal upper limb amyotrophy (HP:0007149)1.57165693
185Transitional cell carcinoma of the bladder (HP:0006740)1.55592572
186Abnormal ossification of hand bones (HP:0005921)1.52293184
187Deviation of the hallux (HP:0010051)1.51302118
188Renal cell carcinoma (HP:0005584)1.50734179
189Coxa vara (HP:0002812)1.50187547
190Nuclear cataract (HP:0100018)1.50123543

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK396.40081105
2MST1R4.52909182
3OXSR14.38724342
4EPHB13.77027012
5MAPKAPK53.59785774
6LATS23.00615580
7FGFR22.92528630
8PKN12.80203834
9PDGFRA2.72388347
10PBK2.42152847
11MET2.26312768
12CDK192.12293678
13BCR2.10043284
14EPHA22.09801797
15PNCK2.06468893
16TTN2.01436350
17PTK22.00375413
18SCYL21.98839208
19WNK41.96708214
20LATS11.90968581
21WNK11.88922463
22CASK1.87796248
23CLK11.86764918
24EPHB21.81180122
25IRAK31.79190985
26UHMK11.78905324
27NTRK11.76008884
28TRIB31.73986881
29EEF2K1.73065144
30EIF2AK11.69741869
31MUSK1.67554435
32PAK41.64640082
33CSNK1A1L1.58707954
34NEK11.56908853
35LMTK21.56029774
36CAMK2B1.52919422
37CSNK1G31.52128109
38TTK1.51983595
39ROCK21.50697753
40KSR11.44525094
41STK241.41994699
42SGK2231.41583981
43SGK4941.41583981
44RIPK11.40023352
45LIMK11.36503953
46FGR1.34904390
47MAP3K21.29582378
48NEK91.26286157
49EPHA41.26042963
50MKNK11.25434804
51CSNK1G11.21632736
52WEE11.19848232
53PAK61.18587939
54CAMK2D1.16679567
55STK38L1.14995818
56STK31.12730975
57CSNK1G21.12327617
58NEK61.11666054
59MST41.10678604
60MAP3K131.10208840
61TIE11.09523232
62BRSK11.09221500
63TESK21.08066138
64BRSK21.04134995
65ILK1.02571341
66CDK121.01528833
67PLK20.97263593
68CDK80.96295509
69ARAF0.95490594
70MAP3K100.94442328
71PKN20.93658161
72CAMK2G0.92755489
73CAMK2A0.91308743
74CDK140.90808047
75CDK150.89248771
76CDK50.85268410
77PRKCQ0.85058593
78CDK180.82939307
79DYRK20.81179249
80TYRO30.81176130
81ERBB40.80505719
82PRKD10.78499689
83CCNB10.77921603
84MAP3K120.77474351
85CDK11A0.76885426
86ERBB30.76747191
87MTOR0.76701415
88MARK20.76679087
89YES10.75964647
90PAK30.75500217
91TGFBR20.75456331
92MARK10.75319548
93CDC70.72900107
94RPS6KA50.71055482
95GSK3A0.70520018
96CSNK1D0.69966727
97DDR20.68632679
98CHEK20.66772217
99MAP3K80.66753844
100TNIK0.65482422
101STK380.64470396
102PRKCE0.63950046
103CDK60.61616214
104SIK10.59463737
105PRPF4B0.58883474
106PRKD30.58505934
107TESK10.58461060
108PDPK10.58378557
109BUB10.58086349
110STK100.57550398
111MAPK130.57475783
112KSR20.57341736
113RPS6KB20.56280112
114NEK20.56207047
115NTRK20.55848298
116NTRK30.55753333
117MOS0.54247792
118TSSK60.54182546
119TRPM70.53928673
120STK110.53664136
121PLK40.53109807
122RET0.52341572
123PRKG10.52132085
124PRKACB0.52049794
125MAP3K90.51537599
126CAMK1G0.50374686
127MYLK0.49743906
128ROCK10.49703223
129FYN0.48325857
130BRD40.48217763
131PLK30.48189354
132ICK0.47397379
133PTK2B0.46765259
134SMG10.46723383
135DMPK0.46295395
136BRAF0.45965420
137BMPR1B0.45422734
138PHKG10.44173910
139PHKG20.44173910
140CSNK1A10.42378667
141BMX0.42360432
142BMPR20.42340866
143AKT20.41909720
144NME20.40010894
145LRRK20.39973370
146FGFR40.39800785
147DAPK20.39714694
148PAK10.38841463
149RAF10.38746449
150CSNK1E0.37651495
151MAP3K40.37598047
152PAK20.37189857
153SGK10.37182448
154AURKB0.36283929
155PLK10.36142511
156PRKCH0.35301141
157PDK10.34931035
158DYRK1A0.33246263
159PDGFRB0.32949028
160MELK0.32420596
161MAPK100.32112351
162PIK3CA0.31835198
163INSR0.30856031
164CSF1R0.27420254
165DAPK30.25991516
166MAP2K70.24684480
167FGFR10.22419891

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.50769687
2Steroid biosynthesis_Homo sapiens_hsa001004.97970397
3Fatty acid elongation_Homo sapiens_hsa000624.93361100
4Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.53522692
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.33882324
6Nitrogen metabolism_Homo sapiens_hsa009103.32445344
7Ether lipid metabolism_Homo sapiens_hsa005653.16175940
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.80526828
9Adherens junction_Homo sapiens_hsa045202.36869011
10Focal adhesion_Homo sapiens_hsa045102.19811852
11Histidine metabolism_Homo sapiens_hsa003402.19207283
12Vitamin B6 metabolism_Homo sapiens_hsa007502.05597159
13Hippo signaling pathway_Homo sapiens_hsa043901.92444400
14Proteoglycans in cancer_Homo sapiens_hsa052051.90249233
15Small cell lung cancer_Homo sapiens_hsa052221.88258695
16Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.83920329
17Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.82645163
18Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.81985782
19Sulfur metabolism_Homo sapiens_hsa009201.80884275
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.78269609
21Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.77694268
22Chronic myeloid leukemia_Homo sapiens_hsa052201.69036494
23Central carbon metabolism in cancer_Homo sapiens_hsa052301.64154679
24Pancreatic cancer_Homo sapiens_hsa052121.59380882
25MicroRNAs in cancer_Homo sapiens_hsa052061.58826905
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.57777425
27Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.56734509
28Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.54433318
29Glioma_Homo sapiens_hsa052141.53724641
30Basal cell carcinoma_Homo sapiens_hsa052171.51656907
31Axon guidance_Homo sapiens_hsa043601.51306971
32Linoleic acid metabolism_Homo sapiens_hsa005911.48886826
33Cell cycle_Homo sapiens_hsa041101.46730699
34Hedgehog signaling pathway_Homo sapiens_hsa043401.45935791
35TGF-beta signaling pathway_Homo sapiens_hsa043501.41737511
36N-Glycan biosynthesis_Homo sapiens_hsa005101.40417769
37Glutamatergic synapse_Homo sapiens_hsa047241.38562956
38Butanoate metabolism_Homo sapiens_hsa006501.35462289
39Bladder cancer_Homo sapiens_hsa052191.35308447
40alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.34793964
41Sphingolipid metabolism_Homo sapiens_hsa006001.34497633
42Dilated cardiomyopathy_Homo sapiens_hsa054141.34286066
43Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.31007204
44GABAergic synapse_Homo sapiens_hsa047271.30949737
45Thyroid cancer_Homo sapiens_hsa052161.30389331
46Protein export_Homo sapiens_hsa030601.29130842
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.28068021
48AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.26158625
49Thyroid hormone signaling pathway_Homo sapiens_hsa049191.17873523
50Endometrial cancer_Homo sapiens_hsa052131.16563500
51Long-term depression_Homo sapiens_hsa047301.15262324
52Serotonergic synapse_Homo sapiens_hsa047261.12603653
53Melanogenesis_Homo sapiens_hsa049161.09235756
54Amoebiasis_Homo sapiens_hsa051461.08908180
55Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.08713421
56Arginine and proline metabolism_Homo sapiens_hsa003301.08073846
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.07317343
58Wnt signaling pathway_Homo sapiens_hsa043101.07076573
59Renal cell carcinoma_Homo sapiens_hsa052111.06452179
60Non-small cell lung cancer_Homo sapiens_hsa052231.06274002
61Melanoma_Homo sapiens_hsa052181.04068279
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.03866248
63Morphine addiction_Homo sapiens_hsa050321.01777249
64Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.01645130
65Pathways in cancer_Homo sapiens_hsa052001.01222060
66Colorectal cancer_Homo sapiens_hsa052100.99960374
67Primary bile acid biosynthesis_Homo sapiens_hsa001200.99141557
68PI3K-Akt signaling pathway_Homo sapiens_hsa041510.97848790
69Ovarian steroidogenesis_Homo sapiens_hsa049130.93309332
70Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.92890756
71Fatty acid metabolism_Homo sapiens_hsa012120.92156734
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.91085611
73Prostate cancer_Homo sapiens_hsa052150.88823862
74Thyroid hormone synthesis_Homo sapiens_hsa049180.85976822
75DNA replication_Homo sapiens_hsa030300.83968078
76Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.82706875
77Long-term potentiation_Homo sapiens_hsa047200.79298461
78Protein digestion and absorption_Homo sapiens_hsa049740.78416302
79Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.76789831
80VEGF signaling pathway_Homo sapiens_hsa043700.76533358
81Glycosaminoglycan degradation_Homo sapiens_hsa005310.76521059
82Estrogen signaling pathway_Homo sapiens_hsa049150.76240244
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.75262336
84Circadian entrainment_Homo sapiens_hsa047130.75096000
85SNARE interactions in vesicular transport_Homo sapiens_hsa041300.74334189
86Pentose phosphate pathway_Homo sapiens_hsa000300.73867664
87Dorso-ventral axis formation_Homo sapiens_hsa043200.73343594
88Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72908471
89Biosynthesis of amino acids_Homo sapiens_hsa012300.72638353
90Non-homologous end-joining_Homo sapiens_hsa034500.70009446
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69943968
92Neurotrophin signaling pathway_Homo sapiens_hsa047220.69376659
93Propanoate metabolism_Homo sapiens_hsa006400.68800665
94Tight junction_Homo sapiens_hsa045300.68220355
95Ras signaling pathway_Homo sapiens_hsa040140.68094007
96Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.67982618
97Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.67728607
98Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67497414
99Inositol phosphate metabolism_Homo sapiens_hsa005620.67329067
100Oocyte meiosis_Homo sapiens_hsa041140.66204820
101Salivary secretion_Homo sapiens_hsa049700.64581899
102mRNA surveillance pathway_Homo sapiens_hsa030150.63459078
103p53 signaling pathway_Homo sapiens_hsa041150.62944133
104Notch signaling pathway_Homo sapiens_hsa043300.62730778
105Lysine degradation_Homo sapiens_hsa003100.62545959
106Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61958435
107Insulin signaling pathway_Homo sapiens_hsa049100.60635658
108Prion diseases_Homo sapiens_hsa050200.59676970
109Gastric acid secretion_Homo sapiens_hsa049710.59256018
110Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.59101339
111Choline metabolism in cancer_Homo sapiens_hsa052310.59007735
112Vascular smooth muscle contraction_Homo sapiens_hsa042700.58810949
113Mismatch repair_Homo sapiens_hsa034300.58555043
114Cocaine addiction_Homo sapiens_hsa050300.58500805
115Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58433586
116mTOR signaling pathway_Homo sapiens_hsa041500.58394373
117Phospholipase D signaling pathway_Homo sapiens_hsa040720.57948862
118Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56365699
119Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.56007737
120Peroxisome_Homo sapiens_hsa041460.55836444
121Gap junction_Homo sapiens_hsa045400.55040793
122RNA transport_Homo sapiens_hsa030130.54695634
123ECM-receptor interaction_Homo sapiens_hsa045120.54083890
124Cholinergic synapse_Homo sapiens_hsa047250.53502698
125Arachidonic acid metabolism_Homo sapiens_hsa005900.53425374
126Leukocyte transendothelial migration_Homo sapiens_hsa046700.52694303
127HIF-1 signaling pathway_Homo sapiens_hsa040660.51576182
128Shigellosis_Homo sapiens_hsa051310.50803877
129Dopaminergic synapse_Homo sapiens_hsa047280.50399278
130AMPK signaling pathway_Homo sapiens_hsa041520.50052532
131Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.49559183
132Fatty acid biosynthesis_Homo sapiens_hsa000610.49089566
133Phototransduction_Homo sapiens_hsa047440.48503192
134Nucleotide excision repair_Homo sapiens_hsa034200.48067846
135Renin secretion_Homo sapiens_hsa049240.46413038
136Phagosome_Homo sapiens_hsa041450.46252163
137Oxidative phosphorylation_Homo sapiens_hsa001900.46176503
138Folate biosynthesis_Homo sapiens_hsa007900.45748149
139Autoimmune thyroid disease_Homo sapiens_hsa053200.45600314
140Endocytosis_Homo sapiens_hsa041440.45236820
141Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44879654
142Glycerophospholipid metabolism_Homo sapiens_hsa005640.44724566
143cGMP-PKG signaling pathway_Homo sapiens_hsa040220.44203828
144Galactose metabolism_Homo sapiens_hsa000520.42953568
145Regulation of actin cytoskeleton_Homo sapiens_hsa048100.42922043
146Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42765885
147Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.42681697
148Alzheimers disease_Homo sapiens_hsa050100.42529369
149Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42426935
150ErbB signaling pathway_Homo sapiens_hsa040120.42301413
151Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.41811971
152Bile secretion_Homo sapiens_hsa049760.41327726
153Arginine biosynthesis_Homo sapiens_hsa002200.41066134
154Chemical carcinogenesis_Homo sapiens_hsa052040.40573799
155Mineral absorption_Homo sapiens_hsa049780.40250620
156Tyrosine metabolism_Homo sapiens_hsa003500.37049279
157Glutathione metabolism_Homo sapiens_hsa004800.36816789
158Vibrio cholerae infection_Homo sapiens_hsa051100.36050628
159Retinol metabolism_Homo sapiens_hsa008300.35575610
160Pyruvate metabolism_Homo sapiens_hsa006200.35542329
161Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34590019
162Nicotine addiction_Homo sapiens_hsa050330.34519596
163Vitamin digestion and absorption_Homo sapiens_hsa049770.34116499
164Complement and coagulation cascades_Homo sapiens_hsa046100.33985217
165Alcoholism_Homo sapiens_hsa050340.33099357
166Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.29537277
167beta-Alanine metabolism_Homo sapiens_hsa004100.28794781
168Metabolic pathways_Homo sapiens_hsa011000.28225183
169Chemokine signaling pathway_Homo sapiens_hsa040620.27749506
170Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.27430560
171Collecting duct acid secretion_Homo sapiens_hsa049660.27297382
172Parkinsons disease_Homo sapiens_hsa050120.26660809
173Rheumatoid arthritis_Homo sapiens_hsa053230.26595074
174ABC transporters_Homo sapiens_hsa020100.26148670
175Cysteine and methionine metabolism_Homo sapiens_hsa002700.25860672
176Rap1 signaling pathway_Homo sapiens_hsa040150.24267768

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