ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	piRNA metabolic process (GO:0034587)	4.08468328
2	behavioral response to nicotine (GO:0035095)	4.05483731
3	regulation of cilium movement (GO:0003352)	3.83083056
4	fucose catabolic process (GO:0019317)	3.78948958
5	L-fucose metabolic process (GO:0042354)	3.78948958
6	L-fucose catabolic process (GO:0042355)	3.78948958
7	protein K11-linked deubiquitination (GO:0035871)	3.78104393
8	regulation of meiosis I (GO:0060631)	3.71641282
9	DNA methylation involved in gamete generation (GO:0043046)	3.70108667
10	water-soluble vitamin biosynthetic process (GO:0042364)	3.63104713
11	response to pheromone (GO:0019236)	3.62746707
12	establishment of protein localization to Golgi (GO:0072600)	3.47184122
13	nonmotile primary cilium assembly (GO:0035058)	3.32262436
14	protein polyglutamylation (GO:0018095)	3.31868922
15	replication fork processing (GO:0031297)	3.31450168
16	male meiosis I (GO:0007141)	3.31258161
17	synapsis (GO:0007129)	3.31086434
18	sperm motility (GO:0030317)	3.30575712
19	DNA double-strand break processing (GO:0000729)	3.29985285
20	detection of light stimulus involved in visual perception (GO:0050908)	3.29118474
21	detection of light stimulus involved in sensory perception (GO:0050962)	3.29118474
22	axoneme assembly (GO:0035082)	3.27996581
23	protein targeting to Golgi (GO:0000042)	3.21534989
24	protein localization to Golgi apparatus (GO:0034067)	3.20544960
25	centriole replication (GO:0007099)	3.17694574
26	pyrimidine nucleobase catabolic process (GO:0006208)	3.17108002
27	respiratory chain complex IV assembly (GO:0008535)	3.16934476
28	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.10661249
29	NADH dehydrogenase complex assembly (GO:0010257)	3.10661249
30	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.10661249
31	epithelial cilium movement (GO:0003351)	3.06347102
32	protein K6-linked ubiquitination (GO:0085020)	3.04845447
33	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.02566121
34	multicellular organism reproduction (GO:0032504)	3.01938689
35	RNA destabilization (GO:0050779)	3.01145790
36	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.99885180
37	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.99885180
38	gamma-aminobutyric acid transport (GO:0015812)	2.99021922
39	protein complex biogenesis (GO:0070271)	2.98434789
40	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.95709284
41	centriole assembly (GO:0098534)	2.94494723
42	cilium organization (GO:0044782)	2.88840437
43	cellular ketone body metabolic process (GO:0046950)	2.88503265
44	behavioral response to ethanol (GO:0048149)	2.87144558
45	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.86496303
46	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.84522752
47	neuronal action potential (GO:0019228)	2.82429305
48	positive regulation of meiosis (GO:0045836)	2.80423458
49	resolution of meiotic recombination intermediates (GO:0000712)	2.80372216
50	nucleobase catabolic process (GO:0046113)	2.79288875
51	cilium assembly (GO:0042384)	2.78693762
52	photoreceptor cell maintenance (GO:0045494)	2.78186156
53	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.78086392
54	single strand break repair (GO:0000012)	2.77465740
55	reciprocal DNA recombination (GO:0035825)	2.74805201
56	reciprocal meiotic recombination (GO:0007131)	2.74805201
57	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.74331979
58	mitochondrial respiratory chain complex assembly (GO:0033108)	2.73899997
59	indolalkylamine catabolic process (GO:0046218)	2.73879406
60	tryptophan catabolic process (GO:0006569)	2.73879406
61	indole-containing compound catabolic process (GO:0042436)	2.73879406
62	somite development (GO:0061053)	2.73119885
63	intraciliary transport (GO:0042073)	2.71459161
64	cilium morphogenesis (GO:0060271)	2.71407278
65	indolalkylamine metabolic process (GO:0006586)	2.67192242
66	regulation of action potential (GO:0098900)	2.67169215
67	regulation of DNA endoreduplication (GO:0032875)	2.64863124
68	cytochrome complex assembly (GO:0017004)	2.64331009
69	C4-dicarboxylate transport (GO:0015740)	2.63449204
70	cilium or flagellum-dependent cell motility (GO:0001539)	2.63397659
71	hindbrain development (GO:0030902)	2.63246647
72	protein-cofactor linkage (GO:0018065)	2.62426926
73	acrosome reaction (GO:0007340)	2.62082656
74	cornea development in camera-type eye (GO:0061303)	2.62077737
75	positive regulation of meiotic cell cycle (GO:0051446)	2.60624302
76	neural tube formation (GO:0001841)	2.60408766
77	cilium movement (GO:0003341)	2.59935806
78	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.58291093
79	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.57132153
80	ketone body metabolic process (GO:1902224)	2.56941391
81	regulation of microtubule-based movement (GO:0060632)	2.56937676
82	seminiferous tubule development (GO:0072520)	2.56418731
83	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.51188176
84	microtubule depolymerization (GO:0007019)	2.51169460
85	motile cilium assembly (GO:0044458)	2.50760203
86	recombinational repair (GO:0000725)	2.49994065
87	presynaptic membrane assembly (GO:0097105)	2.49749206
88	kidney morphogenesis (GO:0060993)	2.49553498
89	tryptophan metabolic process (GO:0006568)	2.48350827
90	spermatid development (GO:0007286)	2.48228381
91	double-strand break repair via homologous recombination (GO:0000724)	2.47990181
92	proline transport (GO:0015824)	2.47009546
93	organic cation transport (GO:0015695)	2.46220045
94	preassembly of GPI anchor in ER membrane (GO:0016254)	2.46105449
95	microtubule polymerization or depolymerization (GO:0031109)	2.45795920
96	male meiosis (GO:0007140)	2.45478017
97	meiosis I (GO:0007127)	2.44764390
98	meiotic chromosome segregation (GO:0045132)	2.44133667
99	thyroid hormone metabolic process (GO:0042403)	2.42752333
100	microtubule anchoring (GO:0034453)	2.42231793

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.31985422
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.16489166
3	VDR_22108803_ChIP-Seq_LS180_Human	2.95137069
4	EZH2_22144423_ChIP-Seq_EOC_Human	2.85709635
5	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.78691966
6	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.74791754
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.74169638
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.67703316
9	FUS_26573619_Chip-Seq_HEK293_Human	2.49411719
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.34961040
11	TAF15_26573619_Chip-Seq_HEK293_Human	2.31601634
12	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.22100042
13	EWS_26573619_Chip-Seq_HEK293_Human	2.18981269
14	P300_19829295_ChIP-Seq_ESCs_Human	2.15379415
15	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.09982600
16	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.05936209
17	ER_23166858_ChIP-Seq_MCF-7_Human	2.05052833
18	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.98677774
19	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.97160974
20	IGF1R_20145208_ChIP-Seq_DFB_Human	1.95646066
21	CBP_20019798_ChIP-Seq_JUKART_Human	1.89812812
22	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.89812812
23	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.87641758
24	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.86742565
25	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.77464666
26	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.74430187
27	SMAD4_21799915_ChIP-Seq_A2780_Human	1.71510545
28	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.70083692
29	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.65235548
30	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.63441489
31	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.61975286
32	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.61670484
33	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.60762952
34	STAT3_23295773_ChIP-Seq_U87_Human	1.60032108
35	AR_25329375_ChIP-Seq_VCAP_Human	1.59107820
36	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.55594263
37	TCF4_23295773_ChIP-Seq_U87_Human	1.53889002
38	TP53_22573176_ChIP-Seq_HFKS_Human	1.46346098
39	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.46300480
40	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.46085189
41	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.45961020
42	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.45525641
43	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.44673012
44	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.42818381
45	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.41041177
46	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.40510575
47	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.39137883
48	IRF1_19129219_ChIP-ChIP_H3396_Human	1.39078394
49	BCAT_22108803_ChIP-Seq_LS180_Human	1.36673424
50	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.35495508
51	RUNX2_22187159_ChIP-Seq_PCA_Human	1.35430398
52	RNF2_27304074_Chip-Seq_NSC_Mouse	1.35328309
53	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.35026124
54	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.33431983
55	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.32657152
56	MYC_18940864_ChIP-ChIP_HL60_Human	1.32357693
57	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.30750023
58	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.30750023
59	REST_21632747_ChIP-Seq_MESCs_Mouse	1.30633670
60	NANOG_19829295_ChIP-Seq_ESCs_Human	1.30625141
61	SOX2_19829295_ChIP-Seq_ESCs_Human	1.30625141
62	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.29660332
63	TCF4_22108803_ChIP-Seq_LS180_Human	1.29420483
64	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.28908577
65	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.26718864
66	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.25130158
67	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.24514378
68	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.23111750
69	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.21886070
70	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.21881211
71	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.20936185
72	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.20743060
73	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.18761206
74	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.17168643
75	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.15676980
76	P53_22387025_ChIP-Seq_ESCs_Mouse	1.15408200
77	AR_21572438_ChIP-Seq_LNCaP_Human	1.15055810
78	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.14363956
79	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.12757579
80	JUN_21703547_ChIP-Seq_K562_Human	1.10216036
81	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.09483805
82	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.07166409
83	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.07166409
84	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.05976876
85	NCOR_22424771_ChIP-Seq_293T_Human	1.05905332
86	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.05343249
87	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.05267089
88	CDX2_22108803_ChIP-Seq_LS180_Human	1.04186318
89	TBL1_22424771_ChIP-Seq_293T_Human	1.04000212
90	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.03494273
91	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.03450916
92	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.02517206
93	ETV1_20927104_ChIP-Seq_GIST48_Human	1.02083213
94	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.02061338
95	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.00927382
96	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.00759138
97	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.99213862
98	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.98639772
99	ELK1_19687146_ChIP-ChIP_HELA_Human	0.98486067
100	HOXB7_26014856_ChIP-Seq_BT474_Human	0.98048700

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.19953125
2	MP0006292_abnormal_olfactory_placode	3.19449568
3	MP0003195_calcinosis	2.46455212
4	MP0003787_abnormal_imprinting	2.38342168
5	MP0002102_abnormal_ear_morphology	2.36192574
6	MP0000569_abnormal_digit_pigmentation	2.28793559
7	MP0005551_abnormal_eye_electrophysiolog	2.21694818
8	MP0005646_abnormal_pituitary_gland	2.08426687
9	MP0003880_abnormal_central_pattern	2.07630388
10	MP0001984_abnormal_olfaction	2.06279939
11	MP0002837_dystrophic_cardiac_calcinosis	2.00224186
12	MP0006072_abnormal_retinal_apoptosis	1.93744511
13	MP0009046_muscle_twitch	1.89470107
14	MP0002234_abnormal_pharynx_morphology	1.87173464
15	MP0001485_abnormal_pinna_reflex	1.82640081
16	MP0001986_abnormal_taste_sensitivity	1.81066915
17	MP0005253_abnormal_eye_physiology	1.79308602
18	MP0003646_muscle_fatigue	1.73569372
19	MP0001529_abnormal_vocalization	1.72585405
20	MP0005410_abnormal_fertilization	1.71944448
21	MP0005084_abnormal_gallbladder_morpholo	1.70910654
22	MP0001968_abnormal_touch/_nociception	1.70609546
23	MP0002272_abnormal_nervous_system	1.69973862
24	MP0009745_abnormal_behavioral_response	1.69633217
25	MP0000631_abnormal_neuroendocrine_gland	1.68067680
26	MP0001486_abnormal_startle_reflex	1.67188826
27	MP0000427_abnormal_hair_cycle	1.61975252
28	MP0005645_abnormal_hypothalamus_physiol	1.57913767
29	MP0003121_genomic_imprinting	1.56853479
30	MP0006276_abnormal_autonomic_nervous	1.53907476
31	MP0004885_abnormal_endolymph	1.49172509
32	MP0002822_catalepsy	1.45523707
33	MP0004043_abnormal_pH_regulation	1.45340977
34	MP0003283_abnormal_digestive_organ	1.41215308
35	MP0008995_early_reproductive_senescence	1.40251636
36	MP0004215_abnormal_myocardial_fiber	1.38623790
37	MP0002160_abnormal_reproductive_system	1.36693043
38	MP0000372_irregular_coat_pigmentation	1.36280327
39	MP0004133_heterotaxia	1.36017020
40	MP0003698_abnormal_male_reproductive	1.33429957
41	MP0002736_abnormal_nociception_after	1.32822905
42	MP0002876_abnormal_thyroid_physiology	1.31844390
43	MP0008875_abnormal_xenobiotic_pharmacok	1.30569629
44	MP0001929_abnormal_gametogenesis	1.29450770
45	MP0001293_anophthalmia	1.29305056
46	MP0004147_increased_porphyrin_level	1.28522915
47	MP0002733_abnormal_thermal_nociception	1.27562332
48	MP0008872_abnormal_physiological_respon	1.27224319
49	MP0005389_reproductive_system_phenotype	1.24446511
50	MP0003122_maternal_imprinting	1.24337911
51	MP0003567_abnormal_fetal_cardiomyocyte	1.24155666
52	MP0002638_abnormal_pupillary_reflex	1.22958140
53	MP0002735_abnormal_chemical_nociception	1.22468475
54	MP0002572_abnormal_emotion/affect_behav	1.21779597
55	MP0002928_abnormal_bile_duct	1.21564514
56	MP0002210_abnormal_sex_determination	1.19315828
57	MP0000778_abnormal_nervous_system	1.18926028
58	MP0004142_abnormal_muscle_tone	1.18911440
59	MP0002938_white_spotting	1.18171386
60	MP0008775_abnormal_heart_ventricle	1.16073983
61	MP0008789_abnormal_olfactory_epithelium	1.13717994
62	MP0002064_seizures	1.11917143
63	MP0003878_abnormal_ear_physiology	1.11607074
64	MP0005377_hearing/vestibular/ear_phenot	1.11607074
65	MP0001970_abnormal_pain_threshold	1.11181461
66	MP0001501_abnormal_sleep_pattern	1.10308902
67	MP0005386_behavior/neurological_phenoty	1.10285090
68	MP0004924_abnormal_behavior	1.10285090
69	MP0002557_abnormal_social/conspecific_i	1.10157256
70	MP0002734_abnormal_mechanical_nocicepti	1.06338467
71	MP0003718_maternal_effect	1.05926970
72	MP0000383_abnormal_hair_follicle	1.04554553
73	MP0003635_abnormal_synaptic_transmissio	1.03243376
74	MP0002067_abnormal_sensory_capabilities	1.02188644
75	MP0002163_abnormal_gland_morphology	1.00692045
76	MP0001764_abnormal_homeostasis	0.99710947
77	MP0000653_abnormal_sex_gland	0.99593007
78	MP0002184_abnormal_innervation	0.98275956
79	MP0004742_abnormal_vestibular_system	0.97965039
80	MP0005195_abnormal_posterior_eye	0.97335231
81	MP0001145_abnormal_male_reproductive	0.97234878
82	MP0005391_vision/eye_phenotype	0.96832982
83	MP0004145_abnormal_muscle_electrophysio	0.96809098
84	MP0005379_endocrine/exocrine_gland_phen	0.96406328
85	MP0002063_abnormal_learning/memory/cond	0.96299847
86	MP0000049_abnormal_middle_ear	0.93073039
87	MP0002752_abnormal_somatic_nervous	0.90922887
88	MP0004484_altered_response_of	0.90430353
89	MP0005174_abnormal_tail_pigmentation	0.90300857
90	MP0010386_abnormal_urinary_bladder	0.89084091
91	MP0003011_delayed_dark_adaptation	0.88693290
92	MP0002138_abnormal_hepatobiliary_system	0.87884474
93	MP0008058_abnormal_DNA_repair	0.87300724
94	MP0003890_abnormal_embryonic-extraembry	0.87125076
95	MP0002229_neurodegeneration	0.86960016
96	MP0005075_abnormal_melanosome_morpholog	0.86783713
97	MP0001963_abnormal_hearing_physiology	0.84137769
98	MP0000026_abnormal_inner_ear	0.82922776
99	MP0000566_synostosis	0.82477089
100	MP0001440_abnormal_grooming_behavior	0.81559823

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	3.89701368
2	True hermaphroditism (HP:0010459)	3.80401968
3	Chronic hepatic failure (HP:0100626)	3.68064173
4	Molar tooth sign on MRI (HP:0002419)	3.57131799
5	Abnormality of midbrain morphology (HP:0002418)	3.57131799
6	Pancreatic fibrosis (HP:0100732)	3.55694813
7	Nephronophthisis (HP:0000090)	3.41276260
8	Medial flaring of the eyebrow (HP:0010747)	3.13608186
9	Abnormality of the renal medulla (HP:0100957)	3.08118941
10	Abnormality of the renal cortex (HP:0011035)	3.00135875
11	Congenital stationary night blindness (HP:0007642)	2.95905511
12	Tubulointerstitial nephritis (HP:0001970)	2.94392089
13	Type II lissencephaly (HP:0007260)	2.94320091
14	Hyperventilation (HP:0002883)	2.79400924
15	Inability to walk (HP:0002540)	2.69249460
16	Progressive inability to walk (HP:0002505)	2.60498385
17	Broad-based gait (HP:0002136)	2.59748091
18	Attenuation of retinal blood vessels (HP:0007843)	2.57057097
19	Hyperglycinemia (HP:0002154)	2.55138409
20	Abnormality of macular pigmentation (HP:0008002)	2.52777269
21	Abnormal rod and cone electroretinograms (HP:0008323)	2.46941418
22	Febrile seizures (HP:0002373)	2.46020301
23	Gait imbalance (HP:0002141)	2.45101989
24	Renal cortical cysts (HP:0000803)	2.41584013
25	Cystic liver disease (HP:0006706)	2.40499643
26	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.39226292
27	Absent/shortened dynein arms (HP:0200106)	2.39226292
28	Congenital primary aphakia (HP:0007707)	2.39024082
29	Sclerocornea (HP:0000647)	2.38945920
30	Gaze-evoked nystagmus (HP:0000640)	2.36960287
31	Hypothermia (HP:0002045)	2.33376726
32	Optic nerve hypoplasia (HP:0000609)	2.33372508
33	Nephrogenic diabetes insipidus (HP:0009806)	2.30740477
34	Pendular nystagmus (HP:0012043)	2.25682266
35	Genital tract atresia (HP:0001827)	2.24443485
36	Congenital hepatic fibrosis (HP:0002612)	2.24087388
37	3-Methylglutaconic aciduria (HP:0003535)	2.23137321
38	Vaginal atresia (HP:0000148)	2.22407087
39	Abolished electroretinogram (ERG) (HP:0000550)	2.21278007
40	Hyperglycinuria (HP:0003108)	2.19760947
41	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.17734439
42	Acute encephalopathy (HP:0006846)	2.15649948
43	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.15329951
44	Progressive macrocephaly (HP:0004481)	2.13594835
45	Postaxial foot polydactyly (HP:0001830)	2.11579900
46	Anencephaly (HP:0002323)	2.07228000
47	Abnormal respiratory motile cilium morphology (HP:0005938)	2.06426045
48	Abnormal respiratory epithelium morphology (HP:0012253)	2.06426045
49	Polydipsia (HP:0001959)	2.05005596
50	Abnormal drinking behavior (HP:0030082)	2.05005596
51	Male pseudohermaphroditism (HP:0000037)	2.03285046
52	Acute necrotizing encephalopathy (HP:0006965)	2.01736547
53	Lissencephaly (HP:0001339)	1.98465336
54	Drooling (HP:0002307)	1.97175761
55	Cerebellar dysplasia (HP:0007033)	1.94911940
56	Tubular atrophy (HP:0000092)	1.94801205
57	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.94208958
58	Mitochondrial inheritance (HP:0001427)	1.92913249
59	Septo-optic dysplasia (HP:0100842)	1.91706341
60	Postaxial hand polydactyly (HP:0001162)	1.91409422
61	Decreased central vision (HP:0007663)	1.90977062
62	Abnormality of serine family amino acid metabolism (HP:0010894)	1.89314603
63	Abnormality of glycine metabolism (HP:0010895)	1.89314603
64	Volvulus (HP:0002580)	1.88822916
65	Increased CSF lactate (HP:0002490)	1.88298540
66	Retinal dysplasia (HP:0007973)	1.84667113
67	Methylmalonic acidemia (HP:0002912)	1.81920045
68	Hepatic necrosis (HP:0002605)	1.81743229
69	Tubulointerstitial abnormality (HP:0001969)	1.81437797
70	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.81147922
71	Bony spicule pigmentary retinopathy (HP:0007737)	1.80771240
72	Poor coordination (HP:0002370)	1.80503804
73	Abnormal biliary tract physiology (HP:0012439)	1.79947413
74	Bile duct proliferation (HP:0001408)	1.79947413
75	Ketoacidosis (HP:0001993)	1.78644990
76	Furrowed tongue (HP:0000221)	1.78264384
77	Stomach cancer (HP:0012126)	1.77696644
78	Abnormal ciliary motility (HP:0012262)	1.77109972
79	Hepatocellular necrosis (HP:0001404)	1.76844651
80	Abnormal pancreas size (HP:0012094)	1.75253620
81	Tachypnea (HP:0002789)	1.74963582
82	Pachygyria (HP:0001302)	1.74149614
83	Abnormality of the labia minora (HP:0012880)	1.73291239
84	Excessive salivation (HP:0003781)	1.72988568
85	Occipital encephalocele (HP:0002085)	1.72302845
86	Astigmatism (HP:0000483)	1.71946132
87	Decreased circulating renin level (HP:0003351)	1.71215485
88	Absent speech (HP:0001344)	1.71117019
89	Growth hormone deficiency (HP:0000824)	1.70974611
90	Gonadotropin excess (HP:0000837)	1.70561045
91	Abnormal mitochondria in muscle tissue (HP:0008316)	1.70419992
92	Thyroiditis (HP:0100646)	1.67741340
93	Abnormality of the ileum (HP:0001549)	1.67669331
94	Polyuria (HP:0000103)	1.67340714
95	Sloping forehead (HP:0000340)	1.67086671
96	Protruding tongue (HP:0010808)	1.66405800
97	Increased corneal curvature (HP:0100692)	1.66189119
98	Keratoconus (HP:0000563)	1.66189119
99	Chromsome breakage (HP:0040012)	1.64755039
100	Oligodactyly (hands) (HP:0001180)	1.63650078

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.09627990
2	BMPR1B	4.55386993
3	PINK1	2.85556432
4	MAP4K2	2.72790534
5	WNK3	2.38756655
6	TNIK	2.31816444
7	TAOK3	2.28634642
8	ZAK	2.14452643
9	ADRBK2	2.13027995
10	PLK4	2.04664241
11	CASK	1.96411438
12	INSRR	1.90799247
13	MAPK13	1.90503437
14	NUAK1	1.84406592
15	GRK1	1.82887965
16	BRSK2	1.79917334
17	WNK4	1.75116005
18	MAP3K4	1.73955794
19	PLK2	1.58825140
20	ACVR1B	1.51503316
21	TRIM28	1.42203736
22	MKNK2	1.37470369
23	STK39	1.30602675
24	SIK2	1.25946216
25	STK38L	1.25263310
26	BCR	1.24488126
27	ERBB3	1.23307210
28	EPHA4	1.20314138
29	EIF2AK3	1.18904567
30	MARK1	1.17555111
31	TLK1	1.15516532
32	OXSR1	1.14157916
33	NTRK3	1.13747093
34	PHKG2	1.10122814
35	PHKG1	1.10122814
36	PNCK	1.08206148
37	OBSCN	0.96579144
38	WNK1	0.91162499
39	DYRK2	0.90964235
40	BCKDK	0.89534246
41	PRKCE	0.87913300
42	TIE1	0.86387527
43	CAMKK2	0.85044353
44	PAK3	0.83536631
45	DAPK2	0.83405477
46	WEE1	0.82238623
47	CSNK1G1	0.81048162
48	PRKCG	0.80609266
49	MAP2K7	0.79752628
50	MKNK1	0.76707886
51	STK16	0.75085052
52	TGFBR1	0.74867996
53	ADRBK1	0.72016840
54	EIF2AK1	0.68123776
55	CSNK1G2	0.66943365
56	CDK3	0.66452438
57	MUSK	0.66146306
58	FLT3	0.65719252
59	PTK2B	0.63799404
60	NLK	0.63545696
61	FGFR2	0.62383713
62	MST4	0.62141016
63	TXK	0.60474890
64	AKT3	0.60025367
65	TEC	0.59121676
66	PRKD3	0.58690665
67	PLK3	0.58572007
68	PIK3CA	0.58364622
69	CSNK1G3	0.55967141
70	CAMK2A	0.51810183
71	PIK3CG	0.51703419
72	VRK1	0.49817533
73	PLK1	0.49797829
74	IRAK1	0.49322043
75	ATM	0.47058921
76	NTRK2	0.47008011
77	CSNK1A1L	0.46699549
78	MAPK15	0.45127607
79	STK3	0.44759247
80	PRKACA	0.44355946
81	MINK1	0.43786005
82	ERBB2	0.43155010
83	PRKCQ	0.43086486
84	NEK2	0.42066383
85	NEK1	0.40046913
86	BRSK1	0.39721833
87	PKN1	0.38678873
88	CSNK1A1	0.36877353
89	MAPKAPK3	0.36778509
90	NME1	0.35373288
91	PRKG1	0.35202813
92	PRKAA1	0.34743113
93	DYRK1A	0.34032382
94	TNK2	0.33883667
95	PRKACB	0.33560739
96	CAMK1	0.33468721
97	CSNK1D	0.32978529
98	MARK3	0.32860783
99	RPS6KA5	0.31398891
100	PRKCA	0.30397719

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.83566546
2	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.68152660
3	Phototransduction_Homo sapiens_hsa04744	2.64493156
4	Butanoate metabolism_Homo sapiens_hsa00650	2.43559334
5	Homologous recombination_Homo sapiens_hsa03440	2.39026038
6	Nicotine addiction_Homo sapiens_hsa05033	2.37347895
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.31582997
8	Fanconi anemia pathway_Homo sapiens_hsa03460	2.20558411
9	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.16403887
10	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.12916921
11	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	2.00605762
12	Propanoate metabolism_Homo sapiens_hsa00640	1.98104672
13	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.94830684
14	Basal transcription factors_Homo sapiens_hsa03022	1.93735566
15	Selenocompound metabolism_Homo sapiens_hsa00450	1.91468356
16	Olfactory transduction_Homo sapiens_hsa04740	1.90562064
17	Nitrogen metabolism_Homo sapiens_hsa00910	1.89841469
18	Linoleic acid metabolism_Homo sapiens_hsa00591	1.87951861
19	Regulation of autophagy_Homo sapiens_hsa04140	1.87153275
20	Oxidative phosphorylation_Homo sapiens_hsa00190	1.79776685
21	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.73050762
22	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.72544857
23	Protein export_Homo sapiens_hsa03060	1.69961562
24	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.69366309
25	Non-homologous end-joining_Homo sapiens_hsa03450	1.61572140
26	Caffeine metabolism_Homo sapiens_hsa00232	1.59482499
27	Taste transduction_Homo sapiens_hsa04742	1.50677700
28	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.47832635
29	RNA degradation_Homo sapiens_hsa03018	1.47450472
30	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.44970168
31	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.41494267
32	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.40956237
33	RNA polymerase_Homo sapiens_hsa03020	1.39068559
34	Tryptophan metabolism_Homo sapiens_hsa00380	1.37828094
35	Parkinsons disease_Homo sapiens_hsa05012	1.32528162
36	ABC transporters_Homo sapiens_hsa02010	1.20741792
37	Morphine addiction_Homo sapiens_hsa05032	1.20394361
38	Cardiac muscle contraction_Homo sapiens_hsa04260	1.20091948
39	Insulin secretion_Homo sapiens_hsa04911	1.18560168
40	Ether lipid metabolism_Homo sapiens_hsa00565	1.18083899
41	Peroxisome_Homo sapiens_hsa04146	1.17855053
42	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.08374716
43	Circadian entrainment_Homo sapiens_hsa04713	1.06915636
44	Salivary secretion_Homo sapiens_hsa04970	1.04553372
45	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.04174060
46	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.01488439
47	GABAergic synapse_Homo sapiens_hsa04727	0.97889779
48	Fatty acid metabolism_Homo sapiens_hsa01212	0.96773159
49	Chemical carcinogenesis_Homo sapiens_hsa05204	0.94670453
50	Huntingtons disease_Homo sapiens_hsa05016	0.92596070
51	Glutamatergic synapse_Homo sapiens_hsa04724	0.92397693
52	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.91942684
53	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.88604920
54	Purine metabolism_Homo sapiens_hsa00230	0.86012553
55	Glycerolipid metabolism_Homo sapiens_hsa00561	0.85653306
56	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.83567553
57	Retinol metabolism_Homo sapiens_hsa00830	0.81262349
58	Calcium signaling pathway_Homo sapiens_hsa04020	0.80023251
59	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.78854729
60	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.78613016
61	Alzheimers disease_Homo sapiens_hsa05010	0.78046238
62	Serotonergic synapse_Homo sapiens_hsa04726	0.75539600
63	One carbon pool by folate_Homo sapiens_hsa00670	0.75400758
64	Fatty acid degradation_Homo sapiens_hsa00071	0.74538559
65	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.73264879
66	Fatty acid elongation_Homo sapiens_hsa00062	0.70815295
67	Steroid biosynthesis_Homo sapiens_hsa00100	0.70788091
68	Collecting duct acid secretion_Homo sapiens_hsa04966	0.69872158
69	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.69183987
70	Metabolic pathways_Homo sapiens_hsa01100	0.69052012
71	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.65830125
72	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.64962952
73	Circadian rhythm_Homo sapiens_hsa04710	0.61933107
74	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.61119821
75	RNA transport_Homo sapiens_hsa03013	0.58230653
76	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.56921820
77	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.55994631
78	Dopaminergic synapse_Homo sapiens_hsa04728	0.55875186
79	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.55325242
80	Mineral absorption_Homo sapiens_hsa04978	0.54094844
81	Pyrimidine metabolism_Homo sapiens_hsa00240	0.52919297
82	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.52436375
83	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.48158612
84	beta-Alanine metabolism_Homo sapiens_hsa00410	0.46481953
85	Sulfur metabolism_Homo sapiens_hsa00920	0.42581835
86	cAMP signaling pathway_Homo sapiens_hsa04024	0.41329018
87	Proteasome_Homo sapiens_hsa03050	0.40505950
88	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.39828585
89	Sphingolipid metabolism_Homo sapiens_hsa00600	0.38898958
90	Fat digestion and absorption_Homo sapiens_hsa04975	0.38411377
91	Type II diabetes mellitus_Homo sapiens_hsa04930	0.36999494
92	Amphetamine addiction_Homo sapiens_hsa05031	0.36793702
93	Pancreatic secretion_Homo sapiens_hsa04972	0.36278851
94	Long-term depression_Homo sapiens_hsa04730	0.35662207
95	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.34807694
96	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.34444522
97	Cocaine addiction_Homo sapiens_hsa05030	0.32796956
98	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.32091334
99	Oocyte meiosis_Homo sapiens_hsa04114	0.31373001
100	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.30922005

DPY19L1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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