ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of cilium movement (GO:0003352)	6.92818795
2	microtubule depolymerization (GO:0007019)	5.18786120
3	regulation of centriole replication (GO:0046599)	5.03177300
4	microtubule polymerization or depolymerization (GO:0031109)	4.75632202
5	attachment of spindle microtubules to kinetochore (GO:0008608)	4.58989953
6	centriole replication (GO:0007099)	4.46178935
7	establishment of protein localization to Golgi (GO:0072600)	4.45819184
8	mitochondrial DNA replication (GO:0006264)	4.38976358
9	sperm motility (GO:0030317)	4.28079524
10	glycine transport (GO:0015816)	4.24250948
11	protein targeting to Golgi (GO:0000042)	4.22299450
12	CENP-A containing nucleosome assembly (GO:0034080)	4.13999892
13	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.11578258
14	microtubule severing (GO:0051013)	4.10483574
15	chromatin remodeling at centromere (GO:0031055)	4.05256696
16	negative regulation of cytosolic calcium ion concentration (GO:0051481)	4.04873031
17	single strand break repair (GO:0000012)	3.87651740
18	nucleobase catabolic process (GO:0046113)	3.84837919
19	regulation of microtubule-based movement (GO:0060632)	3.82160111
20	protein polyglutamylation (GO:0018095)	3.80805973
21	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.78737330
22	positive regulation of dendritic spine morphogenesis (GO:0061003)	3.78490273
23	rRNA methylation (GO:0031167)	3.75923174
24	epithelial cilium movement (GO:0003351)	3.66913311
25	histone exchange (GO:0043486)	3.53408266
26	pyrimidine nucleobase catabolic process (GO:0006208)	3.49614362
27	rRNA modification (GO:0000154)	3.46239802
28	axonemal dynein complex assembly (GO:0070286)	3.44742204
29	regulation of centrosome duplication (GO:0010824)	3.42674323
30	short-term memory (GO:0007614)	3.41610753
31	synaptic vesicle endocytosis (GO:0048488)	3.40333281
32	mitochondrial DNA metabolic process (GO:0032042)	3.34562386
33	protein localization to Golgi apparatus (GO:0034067)	3.26859647
34	cilium movement (GO:0003341)	3.18569772
35	microtubule nucleation (GO:0007020)	3.18517252
36	otic vesicle formation (GO:0030916)	3.13436218
37	centriole assembly (GO:0098534)	3.12536558
38	DNA-dependent DNA replication (GO:0006261)	3.06985466
39	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	3.05851508
40	intraciliary transport (GO:0042073)	3.05784356
41	retinal rod cell development (GO:0046548)	3.05026182
42	spermatid nucleus differentiation (GO:0007289)	3.02924247
43	behavioral response to ethanol (GO:0048149)	2.99308394
44	mitotic spindle organization (GO:0007052)	2.98157984
45	regulation of centrosome cycle (GO:0046605)	2.97174011
46	motile cilium assembly (GO:0044458)	2.92702771
47	DNA replication-independent nucleosome assembly (GO:0006336)	2.91225069
48	DNA replication-independent nucleosome organization (GO:0034724)	2.91225069
49	positive regulation of collagen biosynthetic process (GO:0032967)	2.89284979
50	negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)	2.88481623
51	seminiferous tubule development (GO:0072520)	2.84401303
52	glycerol ether metabolic process (GO:0006662)	2.81166983
53	cilium or flagellum-dependent cell motility (GO:0001539)	2.78436980
54	ribonucleoprotein complex disassembly (GO:0032988)	2.77053684
55	fusion of sperm to egg plasma membrane (GO:0007342)	2.76228665
56	acrosome reaction (GO:0007340)	2.76028726
57	mitotic sister chromatid segregation (GO:0000070)	2.73662003
58	response to pheromone (GO:0019236)	2.70319908
59	positive regulation of collagen metabolic process (GO:0010714)	2.69728966
60	cullin deneddylation (GO:0010388)	2.69382247
61	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	2.65489549
62	protein K48-linked deubiquitination (GO:0071108)	2.63893761
63	glomerular visceral epithelial cell development (GO:0072015)	2.61815325
64	ether metabolic process (GO:0018904)	2.59829561
65	cilium morphogenesis (GO:0060271)	2.58604493
66	regulation of pigment cell differentiation (GO:0050932)	2.55492550
67	neurofilament cytoskeleton organization (GO:0060052)	2.55207186
68	spermatid development (GO:0007286)	2.54735246
69	chromosome condensation (GO:0030261)	2.54194792
70	microtubule anchoring (GO:0034453)	2.53225768
71	DNA packaging (GO:0006323)	2.52033242
72	DNA double-strand break processing (GO:0000729)	2.51328557
73	regulation of protein glycosylation (GO:0060049)	2.49570219
74	cilium assembly (GO:0042384)	2.48999053
75	atrial cardiac muscle cell action potential (GO:0086014)	2.46854357
76	spermatogenesis (GO:0007283)	2.46152263
77	C4-dicarboxylate transport (GO:0015740)	2.46058900
78	protein localization to cilium (GO:0061512)	2.46003071
79	positive regulation of developmental pigmentation (GO:0048087)	2.45766936
80	male gamete generation (GO:0048232)	2.45677055
81	cilium organization (GO:0044782)	2.45412666
82	regulation of cofactor metabolic process (GO:0051193)	2.44182999
83	regulation of coenzyme metabolic process (GO:0051196)	2.44182999
84	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.41336246
85	organelle disassembly (GO:1903008)	2.40059338
86	recombinational repair (GO:0000725)	2.37956259
87	L-serine metabolic process (GO:0006563)	2.37901427
88	sister chromatid segregation (GO:0000819)	2.36880121
89	intra-Golgi vesicle-mediated transport (GO:0006891)	2.36268316
90	mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)	2.36100095
91	regulation of acyl-CoA biosynthetic process (GO:0050812)	2.35637471
92	double-strand break repair via homologous recombination (GO:0000724)	2.35457384
93	microtubule organizing center organization (GO:0031023)	2.33894070
94	peristalsis (GO:0030432)	2.33561543
95	gamma-aminobutyric acid transport (GO:0015812)	2.33013686
96	retinal ganglion cell axon guidance (GO:0031290)	2.32678702
97	gamete generation (GO:0007276)	2.32651985
98	auditory behavior (GO:0031223)	2.32447541
99	deoxyribonucleoside diphosphate metabolic process (GO:0009186)	2.31720188
100	centrosome organization (GO:0051297)	2.31634816

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.79098956
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.37394032
3	E2F7_22180533_ChIP-Seq_HELA_Human	3.35856931
4	FUS_26573619_Chip-Seq_HEK293_Human	2.96875998
5	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.93199319
6	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.85247110
7	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.69128436
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.66804950
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.38510738
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.23607606
11	VDR_22108803_ChIP-Seq_LS180_Human	2.22910579
12	TAF15_26573619_Chip-Seq_HEK293_Human	2.15771300
13	P300_19829295_ChIP-Seq_ESCs_Human	2.13038544
14	ZNF274_21170338_ChIP-Seq_K562_Hela	2.11749083
15	EWS_26573619_Chip-Seq_HEK293_Human	2.08634716
16	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.03920827
17	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.03226971
18	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.01754622
19	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.01314845
20	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.00246947
21	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.94654810
22	CBP_20019798_ChIP-Seq_JUKART_Human	1.94654810
23	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.94364225
24	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.83729593
25	SMAD4_21799915_ChIP-Seq_A2780_Human	1.83665655
26	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.83208119
27	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.82140712
28	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.78358839
29	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.69581642
30	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.68821090
31	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.66828762
32	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.65227177
33	ER_23166858_ChIP-Seq_MCF-7_Human	1.64102462
34	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.60827564
35	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.60397469
36	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.60265185
37	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.59350685
38	STAT3_23295773_ChIP-Seq_U87_Human	1.57520542
39	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.55633822
40	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.55633822
41	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.52344047
42	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.52084657
43	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.50890191
44	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.50479287
45	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.49741607
46	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.45095031
47	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.44996365
48	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.44863258
49	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.44538798
50	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.40518916
51	TP53_18474530_ChIP-ChIP_U2OS_Human	1.36862678
52	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.34795279
53	TP53_22573176_ChIP-Seq_HFKS_Human	1.32595446
54	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.29563331
55	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.29423888
56	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.28232301
57	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.28206202
58	AR_25329375_ChIP-Seq_VCAP_Human	1.27934894
59	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.27467875
60	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.26197838
61	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.26192984
62	TCF4_23295773_ChIP-Seq_U87_Human	1.24254024
63	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.23870266
64	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.23098771
65	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.23038150
66	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.20846779
67	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.20566832
68	ELK1_19687146_ChIP-ChIP_HELA_Human	1.19593074
69	IRF1_19129219_ChIP-ChIP_H3396_Human	1.17699369
70	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.17206095
71	RUNX2_22187159_ChIP-Seq_PCA_Human	1.17188766
72	TCF4_22108803_ChIP-Seq_LS180_Human	1.17088233
73	NANOG_19829295_ChIP-Seq_ESCs_Human	1.15496067
74	SOX2_19829295_ChIP-Seq_ESCs_Human	1.15496067
75	RNF2_27304074_Chip-Seq_NSC_Mouse	1.15048480
76	P53_22387025_ChIP-Seq_ESCs_Mouse	1.14679859
77	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.13230182
78	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.12303459
79	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.11306312
80	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.11109810
81	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.09344962
82	SOX9_26525672_Chip-Seq_HEART_Mouse	1.09338774
83	EZH2_22144423_ChIP-Seq_EOC_Human	1.09247313
84	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.09232119
85	P300_18555785_Chip-Seq_ESCs_Mouse	1.07126466
86	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.05724343
87	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.05222109
88	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.05186424
89	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.04726208
90	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.02461108
91	MYC_18940864_ChIP-ChIP_HL60_Human	1.01909060
92	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.01712366
93	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.01497910
94	ETV1_20927104_ChIP-Seq_GIST48_Human	0.98467543
95	JUN_21703547_ChIP-Seq_K562_Human	0.97847636
96	TBL1_22424771_ChIP-Seq_293T_Human	0.97518166
97	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	0.97269722
98	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.96447433
99	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.96384507
100	NFYB_21822215_ChIP-Seq_K562_Human	0.96087131

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002822_catalepsy	3.90708712
2	MP0002653_abnormal_ependyma_morphology	3.23554970
3	MP0005248_abnormal_Harderian_gland	2.51192834
4	MP0004270_analgesia	2.37146284
5	MP0000013_abnormal_adipose_tissue	2.22380361
6	MP0005410_abnormal_fertilization	2.10602445
7	MP0009697_abnormal_copulation	2.09398015
8	MP0010386_abnormal_urinary_bladder	2.07962431
9	MP0006054_spinal_hemorrhage	2.03333186
10	MP0004859_abnormal_synaptic_plasticity	1.96221007
11	MP0001968_abnormal_touch/_nociception	1.94363835
12	MP0006072_abnormal_retinal_apoptosis	1.90438964
13	MP0003878_abnormal_ear_physiology	1.90242681
14	MP0005377_hearing/vestibular/ear_phenot	1.90242681
15	MP0002638_abnormal_pupillary_reflex	1.87220315
16	MP0009780_abnormal_chondrocyte_physiolo	1.86005224
17	MP0003195_calcinosis	1.83038202
18	MP0010234_abnormal_vibrissa_follicle	1.80748264
19	MP0001188_hyperpigmentation	1.79367543
20	MP0002736_abnormal_nociception_after	1.78506216
21	MP0005253_abnormal_eye_physiology	1.75539679
22	MP0005551_abnormal_eye_electrophysiolog	1.73038330
23	MP0001984_abnormal_olfaction	1.72930798
24	MP0005379_endocrine/exocrine_gland_phen	1.67368250
25	MP0003136_yellow_coat_color	1.64880700
26	MP0002734_abnormal_mechanical_nocicepti	1.44974455
27	MP0001485_abnormal_pinna_reflex	1.43624745
28	MP0004957_abnormal_blastocyst_morpholog	1.43005761
29	MP0001529_abnormal_vocalization	1.40144637
30	MP0009046_muscle_twitch	1.39292354
31	MP0000778_abnormal_nervous_system	1.37135224
32	MP0010094_abnormal_chromosome_stability	1.36695837
33	MP0001929_abnormal_gametogenesis	1.35781255
34	MP0003937_abnormal_limbs/digits/tail_de	1.34166828
35	MP0002272_abnormal_nervous_system	1.33682014
36	MP0008058_abnormal_DNA_repair	1.33543570
37	MP0003122_maternal_imprinting	1.32470843
38	MP0002909_abnormal_adrenal_gland	1.31324038
39	MP0003950_abnormal_plasma_membrane	1.30339154
40	MP0003698_abnormal_male_reproductive	1.28442766
41	MP0005187_abnormal_penis_morphology	1.27316871
42	MP0002102_abnormal_ear_morphology	1.27023450
43	MP0006276_abnormal_autonomic_nervous	1.26080734
44	MP0000647_abnormal_sebaceous_gland	1.22292348
45	MP0004142_abnormal_muscle_tone	1.22249621
46	MP0000631_abnormal_neuroendocrine_gland	1.21667263
47	MP0001986_abnormal_taste_sensitivity	1.19088700
48	MP0001486_abnormal_startle_reflex	1.18966134
49	MP0001501_abnormal_sleep_pattern	1.16860946
50	MP0006292_abnormal_olfactory_placode	1.15700037
51	MP0003385_abnormal_body_wall	1.15330110
52	MP0000955_abnormal_spinal_cord	1.14994699
53	MP0002184_abnormal_innervation	1.14023159
54	MP0004085_abnormal_heartbeat	1.13964356
55	MP0002837_dystrophic_cardiac_calcinosis	1.12989681
56	MP0005360_urolithiasis	1.11424302
57	MP0001293_anophthalmia	1.06453735
58	MP0003119_abnormal_digestive_system	1.05845973
59	MP0002210_abnormal_sex_determination	1.05214801
60	MP0002751_abnormal_autonomic_nervous	1.04798460
61	MP0002735_abnormal_chemical_nociception	1.04390482
62	MP0003879_abnormal_hair_cell	1.04014540
63	MP0001286_abnormal_eye_development	1.03623323
64	MP0008789_abnormal_olfactory_epithelium	1.03306205
65	MP0002697_abnormal_eye_size	1.02150767
66	MP0003718_maternal_effect	1.01802862
67	MP0005195_abnormal_posterior_eye	1.00701938
68	MP0004147_increased_porphyrin_level	0.98979747
69	MP0005499_abnormal_olfactory_system	0.98667012
70	MP0005394_taste/olfaction_phenotype	0.98667012
71	MP0003633_abnormal_nervous_system	0.97327771
72	MP0002752_abnormal_somatic_nervous	0.96696677
73	MP0005391_vision/eye_phenotype	0.95004943
74	MP0002163_abnormal_gland_morphology	0.94698527
75	MP0002938_white_spotting	0.94232068
76	MP0003137_abnormal_impulse_conducting	0.93573011
77	MP0002127_abnormal_cardiovascular_syste	0.93386634
78	MP0003183_abnormal_peptide_metabolism	0.93000454
79	MP0005670_abnormal_white_adipose	0.92715491
80	MP0003635_abnormal_synaptic_transmissio	0.92211089
81	MP0003077_abnormal_cell_cycle	0.91812951
82	MP0002067_abnormal_sensory_capabilities	0.91199188
83	MP0002233_abnormal_nose_morphology	0.90719235
84	MP0002160_abnormal_reproductive_system	0.87948814
85	MP0000516_abnormal_urinary_system	0.87607513
86	MP0005367_renal/urinary_system_phenotyp	0.87607513
87	MP0009745_abnormal_behavioral_response	0.86181449
88	MP0000427_abnormal_hair_cycle	0.86075558
89	MP0005085_abnormal_gallbladder_physiolo	0.85958300
90	MP0002063_abnormal_learning/memory/cond	0.83420082
91	MP0005084_abnormal_gallbladder_morpholo	0.83328694
92	MP0001145_abnormal_male_reproductive	0.83246985
93	MP0000653_abnormal_sex_gland	0.83128979
94	MP0001963_abnormal_hearing_physiology	0.82357539
95	MP0000003_abnormal_adipose_tissue	0.82003617
96	MP0008932_abnormal_embryonic_tissue	0.81603616
97	MP0004215_abnormal_myocardial_fiber	0.81576405
98	MP0003693_abnormal_embryo_hatching	0.81265423
99	MP0003861_abnormal_nervous_system	0.79894521
100	MP0002882_abnormal_neuron_morphology	0.78656387

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Volvulus (HP:0002580)	4.82050192
2	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	4.06904656
3	True hermaphroditism (HP:0010459)	3.97334968
4	Absent/shortened dynein arms (HP:0200106)	3.86909037
5	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.86909037
6	Chronic bronchitis (HP:0004469)	3.78417603
7	Urethral obstruction (HP:0000796)	3.57989079
8	Pancreatic cysts (HP:0001737)	3.54383333
9	Chronic hepatic failure (HP:0100626)	3.32481583
10	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.31465490
11	Pancreatic fibrosis (HP:0100732)	3.30735025
12	Nephronophthisis (HP:0000090)	3.23606249
13	Medial flaring of the eyebrow (HP:0010747)	3.23559373
14	Congenital primary aphakia (HP:0007707)	3.06967090
15	Molar tooth sign on MRI (HP:0002419)	3.04595619
16	Abnormality of midbrain morphology (HP:0002418)	3.04595619
17	Gait imbalance (HP:0002141)	3.01337329
18	Nephrogenic diabetes insipidus (HP:0009806)	2.95646808
19	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.94872265
20	Intestinal atresia (HP:0011100)	2.84147285
21	Tubulointerstitial nephritis (HP:0001970)	2.79176415
22	Abnormal ciliary motility (HP:0012262)	2.77284033
23	Chromsome breakage (HP:0040012)	2.74716665
24	Abnormality of the ileum (HP:0001549)	2.72817913
25	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.72018658
26	Poor coordination (HP:0002370)	2.71905333
27	Vaginal atresia (HP:0000148)	2.70131734
28	Genital tract atresia (HP:0001827)	2.60535353
29	Duplicated collecting system (HP:0000081)	2.54666518
30	Meckel diverticulum (HP:0002245)	2.52529963
31	Abnormality of the renal medulla (HP:0100957)	2.40013193
32	Type II lissencephaly (HP:0007260)	2.39418962
33	Renal cortical cysts (HP:0000803)	2.38656716
34	Ectopic kidney (HP:0000086)	2.36067656
35	Abnormal respiratory motile cilium physiology (HP:0012261)	2.34969062
36	Sclerocornea (HP:0000647)	2.33643550
37	Colon cancer (HP:0003003)	2.32880283
38	Gaze-evoked nystagmus (HP:0000640)	2.32047712
39	Methylmalonic acidemia (HP:0002912)	2.31581659
40	Abnormality of renal resorption (HP:0011038)	2.28314241
41	Hydroureter (HP:0000072)	2.28282400
42	Hyperkalemia (HP:0002153)	2.25862055
43	Cystic liver disease (HP:0006706)	2.20493789
44	Decreased circulating renin level (HP:0003351)	2.20453226
45	Abnormal respiratory motile cilium morphology (HP:0005938)	2.20366625
46	Abnormal respiratory epithelium morphology (HP:0012253)	2.20366625
47	Abnormality of the renal collecting system (HP:0004742)	2.19017073
48	Lissencephaly (HP:0001339)	2.17180850
49	Rhinitis (HP:0012384)	2.12707702
50	Broad foot (HP:0001769)	2.11215718
51	Abnormality of chromosome stability (HP:0003220)	2.10678632
52	Progressive inability to walk (HP:0002505)	2.10063959
53	Inability to walk (HP:0002540)	2.09206750
54	Proximal tubulopathy (HP:0000114)	2.08010459
55	Hyperventilation (HP:0002883)	2.07564476
56	Abnormality of macular pigmentation (HP:0008002)	2.07302613
57	Submucous cleft hard palate (HP:0000176)	2.06869573
58	Postaxial foot polydactyly (HP:0001830)	2.06799228
59	Broad alveolar ridges (HP:0000187)	2.06768062
60	Abnormality of the renal cortex (HP:0011035)	2.04165132
61	Astigmatism (HP:0000483)	2.03809318
62	Absent forearm bone (HP:0003953)	2.01416908
63	Aplasia involving forearm bones (HP:0009822)	2.01416908
64	Anencephaly (HP:0002323)	1.99684079
65	Bony spicule pigmentary retinopathy (HP:0007737)	1.99500459
66	Abnormality of DNA repair (HP:0003254)	1.97308260
67	Optic nerve hypoplasia (HP:0000609)	1.96022267
68	Hepatoblastoma (HP:0002884)	1.94328008
69	Absent radius (HP:0003974)	1.93962198
70	Methylmalonic aciduria (HP:0012120)	1.92725967
71	Hypoalbuminemia (HP:0003073)	1.87350308
72	Abnormal albumin level (HP:0012116)	1.87350308
73	Pendular nystagmus (HP:0012043)	1.86664774
74	Postural tremor (HP:0002174)	1.85505587
75	Renovascular hypertension (HP:0100817)	1.83781725
76	Progressive cerebellar ataxia (HP:0002073)	1.83638770
77	Oligohydramnios (HP:0001562)	1.83400527
78	Clubbing of toes (HP:0100760)	1.83319807
79	Stage 5 chronic kidney disease (HP:0003774)	1.82488312
80	Aplasia/Hypoplasia of the earlobes (HP:0009906)	1.81510699
81	Sensory axonal neuropathy (HP:0003390)	1.80465402
82	Cone-rod dystrophy (HP:0000548)	1.78858293
83	Specific learning disability (HP:0001328)	1.77334493
84	Sloping forehead (HP:0000340)	1.76416418
85	Abnormality of vitamin B metabolism (HP:0004340)	1.75918962
86	Abnormality of the carotid arteries (HP:0005344)	1.75871947
87	Abnormality of the labia minora (HP:0012880)	1.75336795
88	Focal motor seizures (HP:0011153)	1.73976464
89	Thyroid-stimulating hormone excess (HP:0002925)	1.73146657
90	Abnormality of the preputium (HP:0100587)	1.73023756
91	Nasal polyposis (HP:0100582)	1.72225006
92	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.72141177
93	Progressive external ophthalmoplegia (HP:0000590)	1.72025479
94	Preaxial hand polydactyly (HP:0001177)	1.71983677
95	Intellectual disability, moderate (HP:0002342)	1.71623749
96	Occipital encephalocele (HP:0002085)	1.71047577
97	Postaxial hand polydactyly (HP:0001162)	1.69221907
98	Oculomotor apraxia (HP:0000657)	1.67068212
99	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.66068503
100	Bifid tongue (HP:0010297)	1.64683023

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NEK1	9.10087036
2	PLK4	5.02796148
3	NEK2	3.19887984
4	MAP4K2	2.87817543
5	WNK3	2.49180019
6	FRK	2.33729060
7	MKNK2	2.31655010
8	BRD4	2.21366104
9	PLK2	2.19540005
10	TRIM28	2.12821352
11	ZAK	1.93879069
12	TNIK	1.92380658
13	CASK	1.59747875
14	PKN2	1.54655417
15	MAP3K4	1.54117922
16	MKNK1	1.52031019
17	FLT3	1.41506962
18	CDC7	1.39368228
19	INSRR	1.27505274
20	UHMK1	1.27436880
21	CCNB1	1.23312632
22	EIF2AK1	1.23282555
23	AKT3	1.21091688
24	CSNK1G1	1.20621102
25	WNK4	1.15763140
26	CSNK1G2	1.13073394
27	CSNK1G3	1.09514036
28	CSNK1A1L	1.09347094
29	MAP3K12	1.08262686
30	EIF2AK3	1.04336098
31	BCR	1.04261246
32	SRPK1	1.00801181
33	BMPR1B	1.00465454
34	ADRBK2	0.94603830
35	STK39	0.90561879
36	VRK1	0.83446161
37	PLK3	0.83086585
38	FGFR1	0.81650891
39	RPS6KA4	0.80033163
40	DYRK2	0.78551381
41	MAPK13	0.77714337
42	MARK1	0.77314241
43	MAP3K10	0.77261809
44	ERBB3	0.76582266
45	MAPKAPK5	0.74330708
46	MINK1	0.73441196
47	PRKCG	0.72992842
48	MST1R	0.72420280
49	BCKDK	0.67635877
50	TIE1	0.64730763
51	BRAF	0.60580630
52	PRKD3	0.59494303
53	STK38L	0.58393494
54	PINK1	0.58277647
55	BUB1	0.57288468
56	TLK1	0.57248575
57	PLK1	0.56779490
58	PIK3CG	0.55694522
59	CAMK2A	0.55301523
60	MST4	0.54979003
61	WEE1	0.54280199
62	PAK3	0.52304153
63	PRKCE	0.49712149
64	MAP2K7	0.49571864
65	DYRK3	0.49550841
66	TTK	0.49348466
67	GRK1	0.49037781
68	TAF1	0.48876488
69	AURKB	0.48085448
70	CAMK4	0.47970760
71	FER	0.47002223
72	TESK1	0.45894387
73	MET	0.44555271
74	EPHA4	0.43393975
75	CSNK1A1	0.41618957
76	NME1	0.40160627
77	DAPK2	0.39169325
78	ROCK2	0.38030962
79	BRSK2	0.37324291
80	ATM	0.36190201
81	RPS6KA5	0.35855897
82	CAMK2B	0.35814041
83	NLK	0.34724694
84	DAPK1	0.34050343
85	AURKA	0.33550870
86	PRKACB	0.33462306
87	TRPM7	0.32433147
88	CSNK1E	0.31839469
89	CHEK2	0.31506957
90	CSNK1D	0.29992463
91	CAMK2D	0.28535205
92	OXSR1	0.28256376
93	CDK3	0.26584614
94	NTRK2	0.25530372
95	ADRBK1	0.24927830
96	PRKG1	0.24143342
97	SGK223	0.22875068
98	SGK494	0.22875068
99	MAP3K2	0.22687329
100	OBSCN	0.22471578

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.75363197
2	Propanoate metabolism_Homo sapiens_hsa00640	2.60474289
3	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.51597296
4	Fanconi anemia pathway_Homo sapiens_hsa03460	2.49357715
5	Mismatch repair_Homo sapiens_hsa03430	2.27750512
6	Vitamin B6 metabolism_Homo sapiens_hsa00750	2.25830134
7	Alcoholism_Homo sapiens_hsa05034	2.12503946
8	Homologous recombination_Homo sapiens_hsa03440	2.07140657
9	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.05722415
10	Steroid biosynthesis_Homo sapiens_hsa00100	2.02331994
11	Basal transcription factors_Homo sapiens_hsa03022	2.00333754
12	Taste transduction_Homo sapiens_hsa04742	1.90236090
13	Selenocompound metabolism_Homo sapiens_hsa00450	1.90196846
14	DNA replication_Homo sapiens_hsa03030	1.86162513
15	Nicotine addiction_Homo sapiens_hsa05033	1.83385129
16	RNA transport_Homo sapiens_hsa03013	1.82820924
17	Nitrogen metabolism_Homo sapiens_hsa00910	1.81385761
18	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.75422717
19	Proteasome_Homo sapiens_hsa03050	1.73014573
20	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.69417946
21	Protein export_Homo sapiens_hsa03060	1.65978438
22	Oxidative phosphorylation_Homo sapiens_hsa00190	1.63996678
23	Nucleotide excision repair_Homo sapiens_hsa03420	1.62093064
24	Folate biosynthesis_Homo sapiens_hsa00790	1.60206162
25	Purine metabolism_Homo sapiens_hsa00230	1.55658117
26	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.47160585
27	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.45355751
28	Butanoate metabolism_Homo sapiens_hsa00650	1.41056450
29	Huntingtons disease_Homo sapiens_hsa05016	1.38439688
30	Olfactory transduction_Homo sapiens_hsa04740	1.36943238
31	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.32949358
32	Phototransduction_Homo sapiens_hsa04744	1.32388371
33	Parkinsons disease_Homo sapiens_hsa05012	1.28518620
34	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.24699969
35	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.23455621
36	Morphine addiction_Homo sapiens_hsa05032	1.17698701
37	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.16713631
38	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.12406557
39	RNA degradation_Homo sapiens_hsa03018	1.08606640
40	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.06157767
41	RNA polymerase_Homo sapiens_hsa03020	1.03615200
42	One carbon pool by folate_Homo sapiens_hsa00670	1.03568812
43	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.03421175
44	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.98766812
45	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.94599927
46	Regulation of autophagy_Homo sapiens_hsa04140	0.93948404
47	Sulfur metabolism_Homo sapiens_hsa00920	0.92994530
48	Alzheimers disease_Homo sapiens_hsa05010	0.91934845
49	GABAergic synapse_Homo sapiens_hsa04727	0.91768142
50	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.91360245
51	Oocyte meiosis_Homo sapiens_hsa04114	0.91086797
52	Fatty acid metabolism_Homo sapiens_hsa01212	0.85842582
53	Sphingolipid metabolism_Homo sapiens_hsa00600	0.85268053
54	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.85196047
55	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.84017146
56	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.83032705
57	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.81525081
58	Cell cycle_Homo sapiens_hsa04110	0.80276314
59	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.80255468
60	mRNA surveillance pathway_Homo sapiens_hsa03015	0.77951187
61	Glutamatergic synapse_Homo sapiens_hsa04724	0.77927773
62	Pyrimidine metabolism_Homo sapiens_hsa00240	0.77571121
63	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.77311089
64	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.76049595
65	Base excision repair_Homo sapiens_hsa03410	0.75558123
66	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.75377062
67	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.72898613
68	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.71563871
69	Circadian entrainment_Homo sapiens_hsa04713	0.70833335
70	Adherens junction_Homo sapiens_hsa04520	0.69430518
71	Basal cell carcinoma_Homo sapiens_hsa05217	0.69229257
72	p53 signaling pathway_Homo sapiens_hsa04115	0.67907559
73	Metabolic pathways_Homo sapiens_hsa01100	0.67468485
74	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.67033650
75	Fatty acid degradation_Homo sapiens_hsa00071	0.66549843
76	Cardiac muscle contraction_Homo sapiens_hsa04260	0.63773755
77	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.61170660
78	Ether lipid metabolism_Homo sapiens_hsa00565	0.60652605
79	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.60372846
80	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.59392915
81	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.59130543
82	Axon guidance_Homo sapiens_hsa04360	0.58852614
83	Hippo signaling pathway_Homo sapiens_hsa04390	0.57864622
84	Glutathione metabolism_Homo sapiens_hsa00480	0.57222513
85	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.55742599
86	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.53171565
87	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.52981786
88	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.47795018
89	Arginine biosynthesis_Homo sapiens_hsa00220	0.45643825
90	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.45138543
91	Pyruvate metabolism_Homo sapiens_hsa00620	0.44960853
92	Dopaminergic synapse_Homo sapiens_hsa04728	0.44554697
93	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.42804416
94	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.36841217
95	Carbon metabolism_Homo sapiens_hsa01200	0.36700308
96	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.36416503
97	Long-term depression_Homo sapiens_hsa04730	0.36263913
98	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.35623730
99	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.35067367
100	Serotonergic synapse_Homo sapiens_hsa04726	0.31617367

DPY19L1P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »