DPY19L2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the dpy-19 family. It is highly expressed in testis, and is required for sperm head elongation and acrosome formation during spermatogenesis. Mutations in this gene are associated with an infertility disorder, spermatogenic failure type 9 (SPGF9). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1binding of sperm to zona pellucida (GO:0007339)9.99277409
2plasma membrane fusion (GO:0045026)9.92933194
3motile cilium assembly (GO:0044458)9.86963717
4cell wall macromolecule metabolic process (GO:0044036)9.69266381
5cell wall macromolecule catabolic process (GO:0016998)9.69266381
6cell-cell recognition (GO:0009988)9.63161039
7cilium movement (GO:0003341)9.45277599
8epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.99612536
9male meiosis (GO:0007140)8.99561209
10* spermatid development (GO:0007286)8.75712942
11reproduction (GO:0000003)8.64938503
12synaptonemal complex organization (GO:0070193)8.21661364
13regulation of cilium movement (GO:0003352)7.77734394
14synaptonemal complex assembly (GO:0007130)7.73723502
15single fertilization (GO:0007338)7.25472629
16male meiosis I (GO:0007141)6.61635382
17DNA methylation involved in gamete generation (GO:0043046)6.58259802
18negative regulation of inclusion body assembly (GO:0090084)6.35309048
19fertilization (GO:0009566)6.33261674
20sperm capacitation (GO:0048240)6.30294446
21spermatogenesis (GO:0007283)6.01934641
22male gamete generation (GO:0048232)5.99700399
23ventricular system development (GO:0021591)5.81200064
24chromosome organization involved in meiosis (GO:0070192)5.62885068
25gamete generation (GO:0007276)5.52392023
26meiosis I (GO:0007127)5.34128455
27meiotic nuclear division (GO:0007126)5.34087487
28regulation of inclusion body assembly (GO:0090083)5.13550961
29* cellular process involved in reproduction in multicellular organism (GO:0022412)5.11696422
30microtubule depolymerization (GO:0007019)5.10280144
31organic cation transport (GO:0015695)5.05452288
32* germ cell development (GO:0007281)5.04698588
33seminiferous tubule development (GO:0072520)4.82123615
34meiotic cell cycle (GO:0051321)4.77792746
35cell recognition (GO:0008037)4.65645221
36regulation of microtubule-based movement (GO:0060632)4.61314404
37calcium ion-dependent exocytosis (GO:0017156)4.61120953
38microtubule severing (GO:0051013)4.59286110
39protein localization to cilium (GO:0061512)4.58829524
40regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.53331627
41left/right pattern formation (GO:0060972)4.35681558
42multicellular organismal reproductive process (GO:0048609)4.32476303
43axoneme assembly (GO:0035082)4.28720247
44regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.18642238
45monoubiquitinated protein deubiquitination (GO:0035520)4.17235878
46intraciliary transport (GO:0042073)4.15664692
47response to pheromone (GO:0019236)4.12070775
48somatic diversification of immune receptors via somatic mutation (GO:0002566)4.06095582
49somatic hypermutation of immunoglobulin genes (GO:0016446)4.06095582
50genitalia morphogenesis (GO:0035112)3.99875087
51spermatid nucleus differentiation (GO:0007289)3.77968209
52gene silencing by RNA (GO:0031047)3.77669429
53regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.75862848
54protein polyglutamylation (GO:0018095)3.69925822
55chaperone-mediated protein complex assembly (GO:0051131)3.67753012
56microtubule-based movement (GO:0007018)3.56447845
57synapsis (GO:0007129)3.55096508
58glycerol ether metabolic process (GO:0006662)3.51849947
59nucleoside diphosphate phosphorylation (GO:0006165)3.49283916
60meiotic cell cycle process (GO:1903046)3.48692324
61cilium organization (GO:0044782)3.47441243
62* multicellular organismal development (GO:0007275)3.38977325
63resolution of meiotic recombination intermediates (GO:0000712)3.35645083
64presynaptic membrane assembly (GO:0097105)3.32869952
65negative regulation of organelle assembly (GO:1902116)3.29410478
66membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.28717646
67regulation of relaxation of muscle (GO:1901077)3.27298965
68chromosome condensation (GO:0030261)3.27219338
69cilium assembly (GO:0042384)3.26586261
70DNA packaging (GO:0006323)3.24721346
71ether metabolic process (GO:0018904)3.24390121
72lactate metabolic process (GO:0006089)3.20494637
73regulation of meiosis I (GO:0060631)3.20049504
74protein refolding (GO:0042026)3.18082731
75positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.15091176
76amino-acid betaine transport (GO:0015838)3.14082531
77carnitine transport (GO:0015879)3.14082531
78cellular component assembly involved in morphogenesis (GO:0010927)3.13885778
79GTP biosynthetic process (GO:0006183)3.12458807
80cilium morphogenesis (GO:0060271)3.11337283
81carnitine transmembrane transport (GO:1902603)3.11208095
82alditol metabolic process (GO:0019400)3.09642580
83cardiac myofibril assembly (GO:0055003)3.08213734
84nuclear pore complex assembly (GO:0051292)3.05728123
85L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.04719980
86regulation of centriole replication (GO:0046599)3.04515994
87neurotransmitter-gated ion channel clustering (GO:0072578)3.02632986
88negative regulation of cytosolic calcium ion concentration (GO:0051481)3.00248101
89regulation of helicase activity (GO:0051095)2.99755616
90somite development (GO:0061053)2.98036463
91regulation of spindle checkpoint (GO:0090231)2.97895425
92regulation of actin filament-based movement (GO:1903115)2.96915838
93detection of calcium ion (GO:0005513)2.96107722
94regulation of protein polyubiquitination (GO:1902914)2.95256970
95centriole replication (GO:0007099)2.92747433
96polyol catabolic process (GO:0046174)2.88608456
97negative regulation of DNA recombination (GO:0045910)2.87255703
98centriole assembly (GO:0098534)2.85916082
99mitotic sister chromatid cohesion (GO:0007064)2.81978980
100postsynaptic membrane organization (GO:0001941)2.81665461
101cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.81198699
102definitive hemopoiesis (GO:0060216)2.80533352
103cardiac chamber formation (GO:0003207)2.80443427
104cardiac muscle hypertrophy (GO:0003300)2.78883312
105relaxation of cardiac muscle (GO:0055119)2.78749475
106negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.78683812
107photoreceptor cell maintenance (GO:0045494)2.78363944
108presynaptic membrane organization (GO:0097090)2.78202448
109UTP biosynthetic process (GO:0006228)2.77707628
110protein K11-linked deubiquitination (GO:0035871)2.76025755
111nucleus organization (GO:0006997)2.74580605
112glycerol metabolic process (GO:0006071)2.73723490
113regulation of cell communication by electrical coupling (GO:0010649)2.71547331
114glycolytic process (GO:0006096)2.71011468
115cellular ketone body metabolic process (GO:0046950)2.69350768
116cardiac ventricle formation (GO:0003211)2.69000411
117branched-chain amino acid catabolic process (GO:0009083)2.68908151
118histone H2A acetylation (GO:0043968)2.67734879
119single strand break repair (GO:0000012)2.67662960
120regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.67531233
121gene silencing (GO:0016458)2.67048727
122positive regulation of action potential (GO:0045760)2.64097177
123aggressive behavior (GO:0002118)2.63879545
124cardiac muscle contraction (GO:0060048)2.63801686
125striated muscle hypertrophy (GO:0014897)2.63464449
126cardiac muscle cell development (GO:0055013)2.62910088
127left/right axis specification (GO:0070986)2.61753714
128cell communication involved in cardiac conduction (GO:0086065)2.61419862
129amino acid salvage (GO:0043102)2.59915818
130L-methionine salvage (GO:0071267)2.59915818
131L-methionine biosynthetic process (GO:0071265)2.59915818
132microtubule polymerization or depolymerization (GO:0031109)2.59578804
133regulation of cardiac muscle cell contraction (GO:0086004)2.57699937
134peptidyl-glutamic acid modification (GO:0018200)2.55561053
135negative regulation of DNA repair (GO:0045738)2.54138497
136meiotic chromosome segregation (GO:0045132)2.53330344
137myofibril assembly (GO:0030239)2.53110920
138regulation of cardiac muscle contraction (GO:0055117)2.52355152
139adult heart development (GO:0007512)2.51728041
140epithelial cell differentiation involved in kidney development (GO:0035850)2.51559249
141methionine biosynthetic process (GO:0009086)2.50653914
142positive regulation of amino acid transport (GO:0051957)2.49544937
143nonmotile primary cilium assembly (GO:0035058)2.48843548
144negative regulation of smooth muscle cell differentiation (GO:0051151)2.46519355
145negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.45026087
146negative regulation of calcium ion transmembrane transport (GO:1903170)2.45026087
147righting reflex (GO:0060013)2.44849483
148cell differentiation involved in metanephros development (GO:0072202)2.43905691
149cerebral cortex radially oriented cell migration (GO:0021799)2.43852024
150positive regulation of heart rate (GO:0010460)2.42398751
151ketone body metabolic process (GO:1902224)2.42122613
152sarcomere organization (GO:0045214)2.41748823
153reciprocal meiotic recombination (GO:0007131)2.41742547
154reciprocal DNA recombination (GO:0035825)2.41742547
155neural tube formation (GO:0001841)2.41596081
156regulation of striated muscle contraction (GO:0006942)2.40367136
157somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.39338033
158isotype switching (GO:0045190)2.39338033
159somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.39338033
160regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.36545647
161cardiac cell development (GO:0055006)2.36363217
162positive regulation of vascular permeability (GO:0043117)2.36332070
163positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.36305289
164regulation of heart rate (GO:0002027)2.33336652
165regulation of sarcomere organization (GO:0060297)2.32599593
166membrane depolarization during action potential (GO:0086010)2.31803886
167C4-dicarboxylate transport (GO:0015740)2.31247672
168auditory behavior (GO:0031223)2.31147088
169relaxation of muscle (GO:0090075)2.30760086
170behavioral response to ethanol (GO:0048149)2.30289137
171neuron cell-cell adhesion (GO:0007158)2.30227221
172cilium or flagellum-dependent cell motility (GO:0001539)14.8437194
173fusion of sperm to egg plasma membrane (GO:0007342)13.0417673
174sperm motility (GO:0030317)12.1088449
175axonemal dynein complex assembly (GO:0070286)11.8558187
176acrosome assembly (GO:0001675)10.8978948
177sperm-egg recognition (GO:0035036)10.7792786
178multicellular organism reproduction (GO:0032504)10.5235719
179epithelial cilium movement (GO:0003351)10.3340850
180piRNA metabolic process (GO:0034587)10.1463806
181acrosome reaction (GO:0007340)10.1318495

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.42999922
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.47950003
3GBX2_23144817_ChIP-Seq_PC3_Human3.64821390
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.54441793
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.17556056
6POU3F2_20337985_ChIP-ChIP_501MEL_Human3.09675767
7IGF1R_20145208_ChIP-Seq_DFB_Human3.08706437
8FUS_26573619_Chip-Seq_HEK293_Human2.94464734
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.74717683
10PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.45543757
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.42531665
12RBPJ_22232070_ChIP-Seq_NCS_Mouse2.39301421
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.35795071
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.33957589
15EWS_26573619_Chip-Seq_HEK293_Human2.30091632
16ZNF274_21170338_ChIP-Seq_K562_Hela2.28930760
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.22928682
18CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.20252097
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.18561592
20P300_19829295_ChIP-Seq_ESCs_Human2.12573545
21GATA1_26923725_Chip-Seq_HPCs_Mouse2.11641874
22PIAS1_25552417_ChIP-Seq_VCAP_Human2.07008901
23SMAD4_21799915_ChIP-Seq_A2780_Human2.04489996
24EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.03820852
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse11.0541912
26AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.97849004
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.95699002
28SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.94236118
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.91450655
30ELK4_26923725_Chip-Seq_MESODERM_Mouse1.88866288
31VDR_22108803_ChIP-Seq_LS180_Human1.84654163
32* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.83106912
33TOP2B_26459242_ChIP-Seq_MCF-7_Human1.79326669
34* ER_23166858_ChIP-Seq_MCF-7_Human1.78371781
35GATA1_22025678_ChIP-Seq_K562_Human1.68724073
36STAT3_23295773_ChIP-Seq_U87_Human1.67106655
37SMAD3_21741376_ChIP-Seq_EPCs_Human1.67103921
38SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.67057790
39STAT6_21828071_ChIP-Seq_BEAS2B_Human1.65383362
40NR3C1_21868756_ChIP-Seq_MCF10A_Human1.64286368
41KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.62532987
42UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.61905842
43TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.59459452
44CDX2_19796622_ChIP-Seq_MESCs_Mouse1.59112519
45RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.58719082
46WDR5_24793694_ChIP-Seq_LNCAP_Human1.53580577
47STAT1_17558387_ChIP-Seq_HELA_Human1.50342599
48OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49308015
49PCGF2_27294783_Chip-Seq_NPCs_Mouse1.49184100
50FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.47945270
51KAP1_22055183_ChIP-Seq_ESCs_Mouse1.47838681
52AR_25329375_ChIP-Seq_VCAP_Human1.46592750
53BCAT_22108803_ChIP-Seq_LS180_Human1.43721143
54GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.42892634
55* TAL1_26923725_Chip-Seq_HPCs_Mouse1.42726393
56CBP_20019798_ChIP-Seq_JUKART_Human1.42606071
57IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42606071
58NFE2_27457419_Chip-Seq_LIVER_Mouse1.41197126
59ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.39860290
60TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.39542542
61CBX2_27304074_Chip-Seq_ESCs_Mouse1.37990338
62MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.37254153
63GATA3_21867929_ChIP-Seq_CD8_Mouse1.36360936
64GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31826308
65NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.31516218
66KDM2B_26808549_Chip-Seq_REH_Human1.31016379
67* SOX2_22085726_ChIP-Seq_NPCs_Mouse1.30419694
68SUZ12_27294783_Chip-Seq_NPCs_Mouse1.29895049
69EP300_21415370_ChIP-Seq_HL-1_Mouse1.29765432
70* RUNX2_22187159_ChIP-Seq_PCA_Human1.28680492
71MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.27605885
72EZH2_27304074_Chip-Seq_ESCs_Mouse1.27039577
73REST_21632747_ChIP-Seq_MESCs_Mouse1.26690540
74TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.25845901
75SOX2_21211035_ChIP-Seq_LN229_Gbm1.25421094
76* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.24934320
77MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.24564133
78* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.23424334
79JARID2_20064375_ChIP-Seq_MESCs_Mouse1.23185709
80SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.22508142
81BMI1_23680149_ChIP-Seq_NPCS_Mouse1.21664334
82KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21450965
83* TCF4_22108803_ChIP-Seq_LS180_Human1.19989911
84POU5F1_16153702_ChIP-ChIP_HESCs_Human1.18657695
85FLI1_21867929_ChIP-Seq_TH2_Mouse1.18200374
86LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.17438422
87TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14282015
88POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14282015
89CTBP2_25329375_ChIP-Seq_LNCAP_Human1.13907358
90SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.13372404
91GATA3_21867929_ChIP-Seq_TH1_Mouse1.12990436
92RNF2_27304074_Chip-Seq_NSC_Mouse1.11672231
93NANOG_18555785_Chip-Seq_ESCs_Mouse1.10865034
94IRF1_19129219_ChIP-ChIP_H3396_Human1.10362144
95RUNX1_26923725_Chip-Seq_HPCs_Mouse1.09615912
96CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09447533
97P53_21459846_ChIP-Seq_SAOS-2_Human1.09409800
98CRX_20693478_ChIP-Seq_RETINA_Mouse1.09264732
99* FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06834854
100GF1_26923725_Chip-Seq_HPCs_Mouse1.06342219
101EED_16625203_ChIP-ChIP_MESCs_Mouse1.05874692
102TP53_16413492_ChIP-PET_HCT116_Human1.05823499
103PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.05087640
104E2F1_18555785_Chip-Seq_ESCs_Mouse1.04979535
105LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04932194
106EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04874453
107OCT4_18555785_Chip-Seq_ESCs_Mouse1.04751345
108* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.03602796
109NRF2_20460467_ChIP-Seq_MEFs_Mouse1.02756204
110NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.02756204
111CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02388237
112TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01952539
113ERG_20517297_ChIP-Seq_VCAP_Human1.01325436
114CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01145988
115SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.00970661
116P53_22387025_ChIP-Seq_ESCs_Mouse1.00950983
117CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.00462579
118* TBL1_22424771_ChIP-Seq_293T_Human1.00348911
119PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.00204578
120RAD21_21589869_ChIP-Seq_MESCs_Mouse0.99724612
121NANOG_19829295_ChIP-Seq_ESCs_Human0.99551306
122SOX2_19829295_ChIP-Seq_ESCs_Human0.99551306
123ZFP57_27257070_Chip-Seq_ESCs_Mouse0.99455000
124FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.98672405
125SOX9_26525672_Chip-Seq_HEART_Mouse0.98439461
126* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98233795
127PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.98215077
128* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.97820123
129EZH2_27294783_Chip-Seq_NPCs_Mouse0.97678547
130OCT4_21477851_ChIP-Seq_ESCs_Mouse0.96937268
131EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.96096403
132P300_18555785_Chip-Seq_ESCs_Mouse0.95959561
133KLF4_18555785_Chip-Seq_ESCs_Mouse0.95648415
134TP53_22573176_ChIP-Seq_HFKS_Human0.95560580
135CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.95005346
136EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.94398615
137PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94132872
138TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.94050501
139SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92580118
140EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.91936988
141SPI1_26923725_Chip-Seq_HPCs_Mouse0.91908216
142ESRRB_18555785_Chip-Seq_ESCs_Mouse0.91653448
143RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.91407768
144CMYC_18555785_Chip-Seq_ESCs_Mouse0.91322022
145YY1_22570637_ChIP-Seq_MALME-3M_Human0.89301141
146STAT3_18555785_Chip-Seq_ESCs_Mouse0.89260509
147SOX2_21211035_ChIP-Seq_LN229_Human0.87210052
148RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86606644
149LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.86046212
150SUZ12_18555785_Chip-Seq_ESCs_Mouse0.85817290
151SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.85663723
152NFYB_21822215_ChIP-Seq_K562_Human0.85247998
153TCF4_23295773_ChIP-Seq_U87_Human0.84689969
154* ESET_19884257_ChIP-Seq_ESCs_Mouse0.84553995
155SMAD4_21741376_ChIP-Seq_EPCs_Human0.84201990
156GF1B_26923725_Chip-Seq_HPCs_Mouse0.84112245
157PU1_27457419_Chip-Seq_LIVER_Mouse0.83976124
158FLI1_21867929_ChIP-Seq_CD8_Mouse0.81853214
159TAF15_26573619_Chip-Seq_HEK293_Human0.81820030

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.98267142
2MP0001929_abnormal_gametogenesis5.54587438
3MP0008877_abnormal_DNA_methylation5.29772408
4MP0002210_abnormal_sex_determination3.82628733
5MP0002653_abnormal_ependyma_morphology3.48675646
6MP0002837_dystrophic_cardiac_calcinosis3.42743620
7MP0002161_abnormal_fertility/fecundity3.27406003
8MP0004215_abnormal_myocardial_fiber3.23121634
9MP0001145_abnormal_male_reproductive3.19751415
10MP0004084_abnormal_cardiac_muscle2.89631308
11MP0000653_abnormal_sex_gland2.78999273
12MP0003880_abnormal_central_pattern2.49183500
13MP0005623_abnormal_meninges_morphology2.29427509
14MP0002160_abnormal_reproductive_system2.27734859
15MP0005646_abnormal_pituitary_gland2.06015043
16MP0006276_abnormal_autonomic_nervous2.04233839
17MP0008057_abnormal_DNA_replication2.02029033
18MP0005410_abnormal_fertilization15.0701675
19MP0005670_abnormal_white_adipose1.86503693
20MP0004147_increased_porphyrin_level1.83330367
21MP0004484_altered_response_of1.79687472
22MP0002735_abnormal_chemical_nociception1.79354521
23MP0001486_abnormal_startle_reflex1.72708120
24MP0004859_abnormal_synaptic_plasticity1.69974821
25MP0008775_abnormal_heart_ventricle1.66975624
26MP0006292_abnormal_olfactory_placode1.65857982
27MP0002638_abnormal_pupillary_reflex1.63342639
28MP0001968_abnormal_touch/_nociception1.60044174
29MP0003137_abnormal_impulse_conducting1.57966375
30MP0004085_abnormal_heartbeat1.52456535
31MP0003646_muscle_fatigue1.50828469
32MP0002272_abnormal_nervous_system1.50005700
33MP0000631_abnormal_neuroendocrine_gland1.49476793
34MP0009745_abnormal_behavioral_response1.43631402
35MP0003635_abnormal_synaptic_transmissio1.42900036
36MP0003787_abnormal_imprinting1.42472675
37MP0002282_abnormal_trachea_morphology1.41518374
38MP0001529_abnormal_vocalization1.31922617
39MP0001501_abnormal_sleep_pattern1.30180360
40MP0003122_maternal_imprinting1.29755660
41MP0005645_abnormal_hypothalamus_physiol1.26767880
42MP0005330_cardiomyopathy1.25583924
43MP0008058_abnormal_DNA_repair1.23114724
44MP0002972_abnormal_cardiac_muscle1.20790351
45MP0009046_muscle_twitch1.20701532
46MP0005084_abnormal_gallbladder_morpholo1.19285521
47MP0005389_reproductive_system_phenotype1.19207854
48MP0008789_abnormal_olfactory_epithelium1.18033988
49MP0001984_abnormal_olfaction1.15864181
50MP0002063_abnormal_learning/memory/cond1.14321134
51MP0005647_abnormal_sex_gland1.13852442
52MP0010094_abnormal_chromosome_stability1.13806808
53MP0004233_abnormal_muscle_weight1.13063446
54MP0003283_abnormal_digestive_organ1.13007065
55MP0005385_cardiovascular_system_phenoty1.11998763
56MP0001544_abnormal_cardiovascular_syste1.11998763
57MP0002557_abnormal_social/conspecific_i1.10705682
58MP0001970_abnormal_pain_threshold1.10628119
59MP0005386_behavior/neurological_phenoty1.10608698
60MP0004924_abnormal_behavior1.10608698
61MP0002064_seizures1.09995117
62MP0000778_abnormal_nervous_system1.09626611
63MP0002127_abnormal_cardiovascular_syste1.07273473
64MP0005620_abnormal_muscle_contractility1.06590105
65MP0002734_abnormal_mechanical_nocicepti1.05394780
66MP0009697_abnormal_copulation1.05079923
67MP0004145_abnormal_muscle_electrophysio1.04865656
68MP0001765_abnormal_ion_homeostasis1.04262444
69MP0002067_abnormal_sensory_capabilities1.01576826
70MP0003567_abnormal_fetal_cardiomyocyte1.00309241
71MP0003121_genomic_imprinting0.99366071
72MP0000013_abnormal_adipose_tissue0.98374170
73MP0002733_abnormal_thermal_nociception0.97276239
74MP0006138_congestive_heart_failure0.97089324
75MP0001545_abnormal_hematopoietic_system0.94881373
76MP0005397_hematopoietic_system_phenotyp0.94881373
77MP0004270_analgesia0.94839346
78MP0000516_abnormal_urinary_system0.93889914
79MP0005367_renal/urinary_system_phenotyp0.93889914
80MP0003011_delayed_dark_adaptation0.91433947
81MP0002396_abnormal_hematopoietic_system0.89707809
82MP0008007_abnormal_cellular_replicative0.87150040
83MP0003937_abnormal_limbs/digits/tail_de0.86258899
84MP0001485_abnormal_pinna_reflex0.85651039
85MP0003786_premature_aging0.85022769
86MP0002233_abnormal_nose_morphology0.84002532
87MP0003943_abnormal_hepatobiliary_system0.83753562
88MP0001177_atelectasis0.83546078
89MP0008995_early_reproductive_senescence0.83402123
90MP0004142_abnormal_muscle_tone0.82678602
91MP0005394_taste/olfaction_phenotype0.81082482
92MP0005499_abnormal_olfactory_system0.81082482
93MP0000955_abnormal_spinal_cord0.81057358
94MP0004130_abnormal_muscle_cell0.80644216
95MP0002184_abnormal_innervation0.80236339
96MP0002234_abnormal_pharynx_morphology0.79966263
97MP0004885_abnormal_endolymph0.77825596
98MP0002751_abnormal_autonomic_nervous0.76979262
99MP0001879_abnormal_lymphatic_vessel0.76840452
100MP0010630_abnormal_cardiac_muscle0.76322615
101MP0010368_abnormal_lymphatic_system0.76174426
102MP0003950_abnormal_plasma_membrane0.76031621
103MP0002882_abnormal_neuron_morphology0.75308794
104MP0004808_abnormal_hematopoietic_stem0.73122022
105MP0000569_abnormal_digit_pigmentation0.71561710
106MP0005377_hearing/vestibular/ear_phenot0.65006807
107MP0003878_abnormal_ear_physiology0.65006807
108MP0002928_abnormal_bile_duct0.64135572
109MP0005636_abnormal_mineral_homeostasis0.63000121
110MP0000358_abnormal_cell_content/0.62046556
111MP0004134_abnormal_chest_morphology0.61062022
112MP0003115_abnormal_respiratory_system0.60174484
113MP0003111_abnormal_nucleus_morphology0.59068059
114MP0001293_anophthalmia0.53551333
115MP0003699_abnormal_female_reproductive0.52058773
116MP0003329_amyloid_beta_deposits0.50829576
117MP0001324_abnormal_eye_pigmentation0.45834474
118MP0005551_abnormal_eye_electrophysiolog0.44625296
119MP0009278_abnormal_bone_marrow0.43822540
120MP0006036_abnormal_mitochondrial_physio0.43818583
121MP0001119_abnormal_female_reproductive0.43065152
122MP0005253_abnormal_eye_physiology0.43039776
123MP0004133_heterotaxia0.41761925
124MP0003879_abnormal_hair_cell0.40837113
125MP0002971_abnormal_brown_adipose0.39469259
126MP0005666_abnormal_adipose_tissue0.38793911
127MP0005391_vision/eye_phenotype0.38482827
128MP0003077_abnormal_cell_cycle0.36621140
129MP0003136_yellow_coat_color0.36570021
130MP0001730_embryonic_growth_arrest0.35064970
131MP0002269_muscular_atrophy0.34575004
132MP0003861_abnormal_nervous_system0.32452298
133MP0001764_abnormal_homeostasis0.31726294
134MP0004036_abnormal_muscle_relaxation0.31495871
135MP0004019_abnormal_vitamin_homeostasis0.31243462
136MP0004811_abnormal_neuron_physiology0.30577458
137MP0002822_catalepsy0.30311113
138MP0002152_abnormal_brain_morphology0.29708500
139MP0000313_abnormal_cell_death0.28518672
140MP0010307_abnormal_tumor_latency0.28198442
141MP0000427_abnormal_hair_cycle0.27983844
142MP0001727_abnormal_embryo_implantation0.27302198
143MP0009115_abnormal_fat_cell0.27225526
144MP0002092_abnormal_eye_morphology0.26348260
145MP0002084_abnormal_developmental_patter0.24990070
146MP0001986_abnormal_taste_sensitivity0.23585708
147MP0003633_abnormal_nervous_system0.22998825
148MP0006035_abnormal_mitochondrial_morpho0.22191466
149MP0000604_amyloidosis0.21822519
150MP0000751_myopathy0.21070418
151MP0002102_abnormal_ear_morphology0.20706595
152MP0001661_extended_life_span0.20578137
153MP0003942_abnormal_urinary_system0.19378166
154MP0002572_abnormal_emotion/affect_behav0.18838428
155MP0003631_nervous_system_phenotype0.18827020
156MP0006072_abnormal_retinal_apoptosis0.18391345
157MP0004043_abnormal_pH_regulation0.18273954
158MP0001851_eye_inflammation0.18134644
159MP0002736_abnormal_nociception_after0.17845782
160MP0002229_neurodegeneration0.17604645
161MP0002970_abnormal_white_adipose0.17369387
162MP0001919_abnormal_reproductive_system0.17126278
163MP0002169_no_abnormal_phenotype0.17036226
164MP0002873_normal_phenotype0.16847547
165MP0005195_abnormal_posterior_eye0.16299484
166MP0003045_fibrosis0.15821301
167MP0003634_abnormal_glial_cell0.15739525
168MP0001697_abnormal_embryo_size0.15303778
169MP0000534_abnormal_ureter_morphology0.15230216
170MP0005423_abnormal_somatic_nervous0.14520364
171MP0000001_mammalian_phenotype0.14390355
172MP0000749_muscle_degeneration0.13912571

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium morphology (HP:0005938)9.05668253
2Abnormal respiratory epithelium morphology (HP:0012253)9.05668253
3Abnormal ciliary motility (HP:0012262)8.57387302
4Rhinitis (HP:0012384)8.35434818
5Chronic bronchitis (HP:0004469)7.42741844
6Nasal polyposis (HP:0100582)6.56515694
7Infertility (HP:0000789)6.33333539
8Abnormality of the nasal mucosa (HP:0000433)5.38103902
9Bronchiectasis (HP:0002110)4.92026797
10Nephronophthisis (HP:0000090)4.49400903
11Bronchitis (HP:0012387)4.43295170
12Ependymoma (HP:0002888)4.13501381
13Abnormality of the astrocytes (HP:0100707)3.71787031
14Astrocytoma (HP:0009592)3.71787031
15Bundle branch block (HP:0011710)3.50590873
16Abnormality of the lower motor neuron (HP:0002366)3.49702001
17Male infertility (HP:0003251)3.46033842
18Recurrent sinusitis (HP:0011108)3.45099029
19Sudden death (HP:0001699)3.44444291
20Abnormality of the renal medulla (HP:0100957)3.41998224
21Recurrent otitis media (HP:0000403)3.26465260
22Atrial fibrillation (HP:0005110)3.15851976
23Febrile seizures (HP:0002373)3.15513186
24Pancreatic cysts (HP:0001737)3.14555187
25Agnosia (HP:0010524)3.10898689
26Glioma (HP:0009733)3.10431041
27Tubulointerstitial nephritis (HP:0001970)3.07013715
28Primary atrial arrhythmia (HP:0001692)3.03538786
29Atonic seizures (HP:0010819)2.94439010
30Abnormal spermatogenesis (HP:0008669)2.86002364
31Supraventricular tachycardia (HP:0004755)2.85751133
32Syncope (HP:0001279)2.82682059
33Chronic hepatic failure (HP:0100626)2.82175204
34Medulloblastoma (HP:0002885)2.79952032
35Abnormality of midbrain morphology (HP:0002418)2.78095374
36Molar tooth sign on MRI (HP:0002419)2.78095374
37Rhabdomyosarcoma (HP:0002859)2.77230436
38Supraventricular arrhythmia (HP:0005115)2.76510742
39Amyotrophic lateral sclerosis (HP:0007354)2.74984951
40Fibular hypoplasia (HP:0003038)2.74954022
41Gonadotropin excess (HP:0000837)2.74888396
42Focal motor seizures (HP:0011153)2.70526161
43Medial flaring of the eyebrow (HP:0010747)2.62218193
44Hyperventilation (HP:0002883)2.61520111
45Neoplasm of the oral cavity (HP:0100649)2.60662233
46Tubular atrophy (HP:0000092)2.58076013
47Biliary tract neoplasm (HP:0100574)2.56463075
48Acute lymphatic leukemia (HP:0006721)2.52898263
49Tubulointerstitial abnormality (HP:0001969)2.48882900
50Colon cancer (HP:0003003)2.47355872
51Recurrent bronchitis (HP:0002837)2.43664053
52Left ventricular hypertrophy (HP:0001712)2.33365370
53Impaired proprioception (HP:0010831)2.21071738
54Focal seizures (HP:0007359)2.20494173
55Prolonged QT interval (HP:0001657)2.19023742
56Postaxial foot polydactyly (HP:0001830)2.18679102
57Decreased central vision (HP:0007663)2.17329519
58Heart block (HP:0012722)2.15668098
59Abnormality of the labia minora (HP:0012880)2.15250727
60Azoospermia (HP:0000027)2.14730296
61Genital tract atresia (HP:0001827)2.08603368
62Impulsivity (HP:0100710)2.07736832
63Broad-based gait (HP:0002136)2.07262703
64Renal cortical cysts (HP:0000803)2.05591312
65Absent rod-and cone-mediated responses on ERG (HP:0007688)2.04969910
66Central scotoma (HP:0000603)2.04419377
67Neoplasm of the small intestine (HP:0100833)2.03642723
68Congenital hepatic fibrosis (HP:0002612)2.02879468
69Abnormality of the calf musculature (HP:0001430)2.01975778
70Drooling (HP:0002307)2.01394956
71Vaginal atresia (HP:0000148)2.00919638
72Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.6277809
73Absent/shortened dynein arms (HP:0200106)12.3933255
74Dynein arm defect of respiratory motile cilia (HP:0012255)12.3933255
75Abnormal respiratory motile cilium physiology (HP:0012261)10.1666170
76Upper motor neuron abnormality (HP:0002127)1.98807025
77Abnormality of the anterior horn cell (HP:0006802)1.97589789
78Degeneration of anterior horn cells (HP:0002398)1.97589789
79Calf muscle hypertrophy (HP:0008981)1.97240684
80Stage 5 chronic kidney disease (HP:0003774)1.96929168
81Neoplasm of striated muscle (HP:0009728)1.96590621
82Abnormal EKG (HP:0003115)1.94149659
83Oculomotor apraxia (HP:0000657)1.92466997
84Supernumerary spleens (HP:0009799)1.92049249
85Chronic sinusitis (HP:0011109)1.91483648
86Dysdiadochokinesis (HP:0002075)1.90403052
87Tubulointerstitial fibrosis (HP:0005576)1.89934494
88Dialeptic seizures (HP:0011146)1.89863592
89Absent speech (HP:0001344)1.89837457
90Ventricular tachycardia (HP:0004756)1.88021542
91Abnormal biliary tract morphology (HP:0012440)1.87702614
92Hypoplasia of the capital femoral epiphysis (HP:0003090)1.84282375
93Abolished electroretinogram (ERG) (HP:0000550)1.84082216
94Abnormality of the renal cortex (HP:0011035)1.83999223
95Attenuation of retinal blood vessels (HP:0007843)1.83345885
96Abnormality of macular pigmentation (HP:0008002)1.83023839
97Lipoatrophy (HP:0100578)1.82126137
98Abnormality of dentin (HP:0010299)1.79666404
99Absence seizures (HP:0002121)1.78228598
100Abnormal drinking behavior (HP:0030082)1.77962796
101Polydipsia (HP:0001959)1.77962796
102Abnormal rod and cone electroretinograms (HP:0008323)1.77659430
103Narrow forehead (HP:0000341)1.76323460
104Short ribs (HP:0000773)1.74383019
105Poor coordination (HP:0002370)1.73991434
106Abnormal atrioventricular conduction (HP:0005150)1.73637273
107Methylmalonic acidemia (HP:0002912)1.73298652
108Cholecystitis (HP:0001082)1.73263143
109Abnormal gallbladder physiology (HP:0012438)1.73263143
110Excessive salivation (HP:0003781)1.72876585
111Volvulus (HP:0002580)1.72609633
112Dilated cardiomyopathy (HP:0001644)1.72494821
11311 pairs of ribs (HP:0000878)1.71721422
114Subaortic stenosis (HP:0001682)1.71648336
115Abnormality of the left ventricular outflow tract (HP:0011103)1.71648336
116Hemiparesis (HP:0001269)1.71513790
117Aplasia/Hypoplasia of the fibula (HP:0006492)1.71506347
118Thyroid-stimulating hormone excess (HP:0002925)1.69907556
119Renal dysplasia (HP:0000110)1.69841306
120Type II lissencephaly (HP:0007260)1.69155937
121Facial cleft (HP:0002006)1.68637549
122Muscle hypertrophy of the lower extremities (HP:0008968)1.66881036
123Abnormality of the dental root (HP:0006486)1.66354960
124Taurodontia (HP:0000679)1.66354960
125Abnormality of permanent molar morphology (HP:0011071)1.66354960
126Astigmatism (HP:0000483)1.65439826
127Optic nerve hypoplasia (HP:0000609)1.63555102
128Neoplasm of the rectum (HP:0100743)1.63173948
129Postaxial hand polydactyly (HP:0001162)1.62657690
130Cystic liver disease (HP:0006706)1.61991834
131Pancreatic fibrosis (HP:0100732)1.61000722
132Absent frontal sinuses (HP:0002688)1.58182791
133Spastic tetraparesis (HP:0001285)1.57713050
134Microglossia (HP:0000171)1.56672916
135Aplasia/Hypoplasia of the tongue (HP:0010295)1.55112563
136Abnormality of molar (HP:0011077)1.54803421
137Abnormality of molar morphology (HP:0011070)1.54803421
138Bell-shaped thorax (HP:0001591)1.54716199
139Median cleft lip (HP:0000161)1.53247756
140True hermaphroditism (HP:0010459)1.51895519
141Abnormal biliary tract physiology (HP:0012439)1.51007434
142Bile duct proliferation (HP:0001408)1.51007434
143Abnormality of the dental pulp (HP:0006479)1.50616624
144Gait imbalance (HP:0002141)1.48320938
145Congenital primary aphakia (HP:0007707)1.47990012
146Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.47134576
147J-shaped sella turcica (HP:0002680)1.46682062
148Abnormality of renal excretion (HP:0011036)1.46127917
149Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.43867559
150Absent epiphyses (HP:0010577)1.43867559
151Heterotopia (HP:0002282)1.42524897
152Short thorax (HP:0010306)1.36349120
153Broad distal phalanx of finger (HP:0009836)1.36316418
154Abnormality of ocular smooth pursuit (HP:0000617)1.35549091
155Gaze-evoked nystagmus (HP:0000640)1.33721129
156Nephropathy (HP:0000112)1.30667424
157Nephrogenic diabetes insipidus (HP:0009806)1.27419741
158Aplasia/Hypoplasia of the lens (HP:0008063)1.26817338
159Breast carcinoma (HP:0003002)1.24885888
160Large eyes (HP:0001090)1.24172247
161Dyschromatopsia (HP:0007641)1.22774640
162Occipital encephalocele (HP:0002085)1.21994179
163Conjunctival telangiectasia (HP:0000524)1.21801647
164Decreased motor nerve conduction velocity (HP:0003431)1.21647847
165Pachygyria (HP:0001302)1.18223225
166Deformed sella turcica (HP:0002681)1.17790686
167Selective tooth agenesis (HP:0001592)1.17776926
168Abnormal urine output (HP:0012590)1.17021424
169Short nail (HP:0001799)1.15851802

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.98144372
2PDK38.98144372
3PDK25.85966962
4TESK14.65472630
5MAP4K24.37732349
6PRKD33.86052227
7ICK3.25548687
8FRK3.08964492
9PNCK2.96472166
10BCKDK2.75971094
11PTK2B2.50393319
12TAOK32.28361549
13WNK42.27771073
14CASK2.19554350
15MAPK132.15730447
16STK392.08788018
17EIF2AK31.92716505
18NEK21.92122944
19NUAK11.91802400
20TNIK1.84469679
21ERBB31.81352956
22EPHA41.74005413
23MYLK1.71050123
24MKNK21.62423834
25OBSCN1.59957359
26MKNK11.58474583
27FLT31.56200660
28MAP2K71.46268800
29STK381.39418388
30TRIM281.39225355
31PAK31.36992342
32MAPK151.27621946
33DMPK1.23451180
34BCR1.19869334
35PRKCE1.19749904
36INSRR1.15415127
37DAPK21.08289201
38CSNK1G11.07757278
39WNK11.04128526
40LATS11.01265195
41DYRK1B1.00388690
42STK30.97771431
43CSNK1G30.96889085
44PDK10.93554751
45CSNK1G20.92411068
46PLK20.92369284
47DYRK1A0.91487681
48TYRO30.90565327
49CSNK1A1L0.90446240
50TRPM70.88168181
51PIK3CA0.84429580
52CDC70.83746392
53ACVR1B0.82224251
54PASK0.81954101
55TTK0.81649878
56CCNB10.81356548
57MINK10.78935023
58DYRK20.77388547
59NLK0.76288641
60PINK10.75876826
61ADRBK20.75591306
62WEE10.72058738
63DYRK30.71541962
64NTRK30.71381333
65MAP2K40.70688738
66PHKG20.69688534
67PHKG10.69688534
68ZAK0.67501074
69AKT30.66810467
70IRAK10.65914915
71UHMK10.63794571
72PKN10.63222461
73TGFBR10.62980259
74EIF2AK20.62591567
75NEK10.60874021
76CAMK10.59888201
77MAP3K60.59519854
78CAMK2D0.59343626
79CHEK20.58451450
80PRKAA20.57449176
81CAMK1G0.56897452
82GRK10.54339108
83LMTK20.51647532
84CHEK10.51029144
85ATR0.49881665
86TIE10.49820460
87OXSR10.48871546
88CAMKK20.48375598
89FGFR20.47735917
90STK38L0.47031558
91VRK10.45757631
92TEC0.45318889
93MUSK0.44837590
94TNK20.43628591
95BRD40.42274768
96MAP3K70.41436343
97PLK40.39546578
98NTRK20.39231577
99EEF2K0.37630625
100PDPK10.36604615
101ATM0.36571977
102SGK20.35904520
103BRSK20.34420876
104GRK70.34267121
105CDK50.34170442
106ROCK10.34121909
107PBK0.33700541
108CAMKK10.31386084
109PRKCG0.30770683
110PAK10.30352475
111PLK10.28065758
112MAP2K60.26001964
113IRAK20.24883677
114MTOR0.24841650
115TESK20.24646344
116PRKAA10.23141593
117PAK20.22903561
118BUB10.21899966
119RPS6KB10.19625933
120NEK60.19077737
121BRAF0.17482903
122BMPR1B0.15610428
123MARK20.14973502
124CDK120.14402006
125WNK30.11783237
126MAPKAPK50.09850650
127RIPK40.09522645
128BRSK10.09291317
129MARK30.08507004
130PRKACG0.06921230
131STK100.06615513
132AURKA0.06423071
133CSNK2A10.06336784
134CDK10.06175695
135PRKCZ0.06081785
136MAP3K100.05858170
137PRKG10.05840034
138CSNK1D0.05742969
139CDK150.05346631
140PRKDC0.05167000
141CDK20.04904452
142PRKACB0.04690708
143GSK3B0.04355100
144PAK60.03742317
145CDK30.03544136
146CDK180.03216698
147STK110.03182841
148RPS6KA10.02555914
149CDK11A0.02501535
150CSNK2A20.02189352
151MAPK80.01294766
152PRKCQ0.01213853
153MAP3K40.01103348
154PRKCB0.00608499
155PAK40.00422918
156YES1-0.0470307
157CSF1R-0.0447943
158CSNK1E-0.0413635
159ZAP70-0.0389320
160PIM1-0.0360355
161PRKACA-0.0306349
162PRKCA-0.0236221
163MARK1-0.0229493
164MAPK10-0.0218339
165EGFR-0.0171168
166CDK14-0.0057146
167CAMK2A-0.0031790
168RPS6KA3-0.0009387

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.48659402
2Pyruvate metabolism_Homo sapiens_hsa006204.40630846
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.10160815
4Propanoate metabolism_Homo sapiens_hsa006403.22083730
5Fatty acid biosynthesis_Homo sapiens_hsa000613.07657590
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.07645627
7Glucagon signaling pathway_Homo sapiens_hsa049222.81252325
8Selenocompound metabolism_Homo sapiens_hsa004502.60879781
9Dorso-ventral axis formation_Homo sapiens_hsa043202.57303856
10Basal transcription factors_Homo sapiens_hsa030222.55456985
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.46554812
12Butanoate metabolism_Homo sapiens_hsa006502.45303477
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.42261882
14Linoleic acid metabolism_Homo sapiens_hsa005912.37304598
15Fanconi anemia pathway_Homo sapiens_hsa034602.36680247
16Pentose phosphate pathway_Homo sapiens_hsa000302.19077272
17Oocyte meiosis_Homo sapiens_hsa041142.05478719
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.05331858
19Glycerolipid metabolism_Homo sapiens_hsa005611.98756536
20Non-homologous end-joining_Homo sapiens_hsa034501.91495216
21Phototransduction_Homo sapiens_hsa047441.88346726
22Huntingtons disease_Homo sapiens_hsa050161.82950004
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.82451477
24Dilated cardiomyopathy_Homo sapiens_hsa054141.80895418
25Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.79991101
26Morphine addiction_Homo sapiens_hsa050321.78873951
27Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.76354922
28GABAergic synapse_Homo sapiens_hsa047271.72078055
29Carbohydrate digestion and absorption_Homo sapiens_hsa049731.71336236
30Mismatch repair_Homo sapiens_hsa034301.69515564
31Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.67317702
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.60607588
33Amphetamine addiction_Homo sapiens_hsa050311.59817643
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.57295772
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.56045408
36PPAR signaling pathway_Homo sapiens_hsa033201.47528960
37Glycerophospholipid metabolism_Homo sapiens_hsa005641.47204361
38Fructose and mannose metabolism_Homo sapiens_hsa000511.43500060
39Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.38268575
40Glycosaminoglycan degradation_Homo sapiens_hsa005311.36625195
41Renin secretion_Homo sapiens_hsa049241.31671910
42RNA transport_Homo sapiens_hsa030131.31069926
43mRNA surveillance pathway_Homo sapiens_hsa030151.29733251
44Carbon metabolism_Homo sapiens_hsa012001.29645014
45Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.28741809
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.26830267
47Regulation of autophagy_Homo sapiens_hsa041401.24790682
48Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.22240869
49Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.20781957
50Serotonergic synapse_Homo sapiens_hsa047261.17390046
51Circadian rhythm_Homo sapiens_hsa047101.17295361
52Cardiac muscle contraction_Homo sapiens_hsa042601.16767320
53Antigen processing and presentation_Homo sapiens_hsa046121.16362978
54Peroxisome_Homo sapiens_hsa041461.15964006
55Ether lipid metabolism_Homo sapiens_hsa005651.14214819
56Tryptophan metabolism_Homo sapiens_hsa003801.11457697
57Long-term depression_Homo sapiens_hsa047301.10968307
58Fat digestion and absorption_Homo sapiens_hsa049751.09096392
59Dopaminergic synapse_Homo sapiens_hsa047281.04056132
60Purine metabolism_Homo sapiens_hsa002301.02712837
61Maturity onset diabetes of the young_Homo sapiens_hsa049500.99597699
62Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.98859306
63Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.97181400
64Long-term potentiation_Homo sapiens_hsa047200.95804021
65Mineral absorption_Homo sapiens_hsa049780.94373904
66Oxytocin signaling pathway_Homo sapiens_hsa049210.93513140
67Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.92238612
682-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.91832495
69ABC transporters_Homo sapiens_hsa020100.87364043
70Nitrogen metabolism_Homo sapiens_hsa009100.83765296
71beta-Alanine metabolism_Homo sapiens_hsa004100.83250276
72Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.83209935
73Fatty acid metabolism_Homo sapiens_hsa012120.82668954
74Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.81197514
75Biosynthesis of amino acids_Homo sapiens_hsa012300.81121425
76Parkinsons disease_Homo sapiens_hsa050120.80468968
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.77657642
78Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.75463085
79Gap junction_Homo sapiens_hsa045400.75296603
80Glutathione metabolism_Homo sapiens_hsa004800.74456990
81Estrogen signaling pathway_Homo sapiens_hsa049150.74243496
82Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.73849322
83Cholinergic synapse_Homo sapiens_hsa047250.73697144
84Ovarian steroidogenesis_Homo sapiens_hsa049130.73365770
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72995162
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.72354853
87Base excision repair_Homo sapiens_hsa034100.71955111
88Collecting duct acid secretion_Homo sapiens_hsa049660.71583244
89Aldosterone synthesis and secretion_Homo sapiens_hsa049250.71351959
90Fatty acid degradation_Homo sapiens_hsa000710.70706233
91Fatty acid elongation_Homo sapiens_hsa000620.70459622
92Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.66990769
93cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66628235
94Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.66195259
95Calcium signaling pathway_Homo sapiens_hsa040200.64743051
96Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64241016
97Hedgehog signaling pathway_Homo sapiens_hsa043400.63089757
98Oxidative phosphorylation_Homo sapiens_hsa001900.58115080
99Lysine degradation_Homo sapiens_hsa003100.57207118
100Central carbon metabolism in cancer_Homo sapiens_hsa052300.56838263
101Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56688723
102Systemic lupus erythematosus_Homo sapiens_hsa053220.56567408
103Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.56209317
104Arachidonic acid metabolism_Homo sapiens_hsa005900.54642111
105AMPK signaling pathway_Homo sapiens_hsa041520.54137466
106Primary bile acid biosynthesis_Homo sapiens_hsa001200.52902315
107N-Glycan biosynthesis_Homo sapiens_hsa005100.52722954
108DNA replication_Homo sapiens_hsa030300.52529701
109Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50368919
110Chemical carcinogenesis_Homo sapiens_hsa052040.49924380
111Nucleotide excision repair_Homo sapiens_hsa034200.49889165
112Legionellosis_Homo sapiens_hsa051340.49415668
113Protein export_Homo sapiens_hsa030600.47738439
114Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47692504
115Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47393866
116Homologous recombination_Homo sapiens_hsa034400.47388018
117Adipocytokine signaling pathway_Homo sapiens_hsa049200.47229282
118Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46399347
119Retinol metabolism_Homo sapiens_hsa008300.45592646
120Insulin secretion_Homo sapiens_hsa049110.44803862
121Inositol phosphate metabolism_Homo sapiens_hsa005620.44433331
122Taste transduction_Homo sapiens_hsa047420.44288816
123Alzheimers disease_Homo sapiens_hsa050100.41308430
124Thyroid hormone synthesis_Homo sapiens_hsa049180.41172851
125VEGF signaling pathway_Homo sapiens_hsa043700.41120029
126Renin-angiotensin system_Homo sapiens_hsa046140.40170093
127Circadian entrainment_Homo sapiens_hsa047130.38712267
128Pyrimidine metabolism_Homo sapiens_hsa002400.38684404
129Endocytosis_Homo sapiens_hsa041440.38259686
130Synaptic vesicle cycle_Homo sapiens_hsa047210.37504691
131RNA polymerase_Homo sapiens_hsa030200.37376207
132Metabolic pathways_Homo sapiens_hsa011000.37339542
133RNA degradation_Homo sapiens_hsa030180.35159164
134Cell cycle_Homo sapiens_hsa041100.32988368
135Bile secretion_Homo sapiens_hsa049760.31802298
136Sulfur metabolism_Homo sapiens_hsa009200.31007149
137Sphingolipid metabolism_Homo sapiens_hsa006000.30888708
138Alcoholism_Homo sapiens_hsa050340.27847550
139Salivary secretion_Homo sapiens_hsa049700.26927738
140cAMP signaling pathway_Homo sapiens_hsa040240.25496366
141Pancreatic secretion_Homo sapiens_hsa049720.24658762
142Vascular smooth muscle contraction_Homo sapiens_hsa042700.23766205
143Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.23157032
144Gastric acid secretion_Homo sapiens_hsa049710.22792543
145Wnt signaling pathway_Homo sapiens_hsa043100.21718936
146Olfactory transduction_Homo sapiens_hsa047400.21694209
147Glutamatergic synapse_Homo sapiens_hsa047240.20080922
148Viral carcinogenesis_Homo sapiens_hsa052030.18906867
149Protein digestion and absorption_Homo sapiens_hsa049740.16078891
150Thyroid hormone signaling pathway_Homo sapiens_hsa049190.14237919
151Cocaine addiction_Homo sapiens_hsa050300.14170790
152Nicotine addiction_Homo sapiens_hsa050330.11882767

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