Rank | Gene Set | Z-score |
---|---|---|
1 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO | 7.01276523 |
2 | regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882) | 6.54798860 |
3 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 6.00362219 |
4 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880) | 5.87694324 |
5 | positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316) | 5.62475345 |
6 | cardiac myofibril assembly (GO:0055003) | 5.39535864 |
7 | regulation of actin filament-based movement (GO:1903115) | 5.18330915 |
8 | cell communication involved in cardiac conduction (GO:0086065) | 5.09604204 |
9 | cell communication by electrical coupling (GO:0010644) | 5.00166460 |
10 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 4.99985314 |
11 | cardiac muscle contraction (GO:0060048) | 4.95487700 |
12 | regulation of relaxation of muscle (GO:1901077) | 4.93150657 |
13 | sarcomere organization (GO:0045214) | 4.77368161 |
14 | myofibril assembly (GO:0030239) | 4.72438603 |
15 | regulation of cell communication by electrical coupling (GO:0010649) | 4.69761738 |
16 | regulation of cardiac muscle cell contraction (GO:0086004) | 4.56079970 |
17 | detection of calcium ion (GO:0005513) | 4.51274425 |
18 | cardiac muscle hypertrophy (GO:0003300) | 4.50500660 |
19 | relaxation of cardiac muscle (GO:0055119) | 4.40183570 |
20 | regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314) | 4.34182023 |
21 | striated muscle hypertrophy (GO:0014897) | 4.24526189 |
22 | adult heart development (GO:0007512) | 4.08027753 |
23 | cardiac chamber formation (GO:0003207) | 4.03606232 |
24 | cardiac muscle cell development (GO:0055013) | 4.01150170 |
25 | ventricular cardiac muscle cell action potential (GO:0086005) | 3.99906351 |
26 | regulation of cardiac muscle contraction (GO:0055117) | 3.88376500 |
27 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 3.86134480 |
28 | regulation of the force of heart contraction (GO:0002026) | 3.85713922 |
29 | positive regulation of calcium ion transmembrane transporter activity (GO:1901021) | 3.80139179 |
30 | regulation of striated muscle contraction (GO:0006942) | 3.75827899 |
31 | cardiac cell development (GO:0055006) | 3.67654522 |
32 | cardiac muscle cell action potential (GO:0086001) | 3.63142436 |
33 | regulation of heart rate (GO:0002027) | 3.62441515 |
34 | muscle hypertrophy (GO:0014896) | 3.61641893 |
35 | cardiac ventricle formation (GO:0003211) | 3.60259553 |
36 | ventricular cardiac muscle tissue morphogenesis (GO:0055010) | 3.58772501 |
37 | cardiac muscle tissue morphogenesis (GO:0055008) | 3.54556644 |
38 | response to caffeine (GO:0031000) | 3.50873890 |
39 | regulation of cardioblast differentiation (GO:0051890) | 3.50203102 |
40 | bundle of His cell to Purkinje myocyte communication (GO:0086069) | 3.45829022 |
41 | actin-myosin filament sliding (GO:0033275) | 3.44657180 |
42 | muscle filament sliding (GO:0030049) | 3.44657180 |
43 | striated muscle contraction (GO:0006941) | 3.43362413 |
44 | regulation of sarcomere organization (GO:0060297) | 3.40214816 |
45 | cardiac muscle cell action potential involved in contraction (GO:0086002) | 3.39821315 |
46 | negative regulation of cardiac muscle cell apoptotic process (GO:0010667) | 3.38700720 |
47 | adrenergic receptor signaling pathway (GO:0071875) | 3.33799385 |
48 | negative regulation of cytosolic calcium ion concentration (GO:0051481) | 3.31529775 |
49 | cardiac conduction (GO:0061337) | 3.31371369 |
50 | positive regulation of action potential (GO:0045760) | 3.25568543 |
51 | regulation of ATPase activity (GO:0043462) | 3.25554873 |
52 | regulation of ATP catabolic process (GO:1903289) | 3.25554873 |
53 | positive regulation of heart rate (GO:0010460) | 3.23536527 |
54 | regulation of membrane repolarization (GO:0060306) | 3.22939410 |
55 | actomyosin structure organization (GO:0031032) | 3.22591143 |
56 | muscle tissue morphogenesis (GO:0060415) | 3.17985193 |
57 | sarcoplasmic reticulum calcium ion transport (GO:0070296) | 3.15217176 |
58 | relaxation of muscle (GO:0090075) | 3.04453936 |
59 | regulation of heart contraction (GO:0008016) | 3.01433340 |
60 | positive regulation of ATPase activity (GO:0032781) | 2.98663657 |
61 | positive regulation of ATP catabolic process (GO:1903291) | 2.98663657 |
62 | regulation of calcium ion transmembrane transporter activity (GO:1901019) | 2.98628327 |
63 | regulation of calcium ion transmembrane transport (GO:1903169) | 2.98628327 |
64 | positive regulation of cardiac muscle cell differentiation (GO:2000727) | 2.97848147 |
65 | membrane depolarization during action potential (GO:0086010) | 2.95466217 |
66 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 2.94073838 |
67 | negative regulation of potassium ion transmembrane transporter activity (GO:1901017) | 2.91195310 |
68 | actin-mediated cell contraction (GO:0070252) | 2.90308741 |
69 | heart contraction (GO:0060047) | 2.90228167 |
70 | heart process (GO:0003015) | 2.90228167 |
71 | regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307) | 2.82831560 |
72 | positive regulation of sodium ion transport (GO:0010765) | 2.82269330 |
73 | multicellular organismal signaling (GO:0035637) | 2.79212842 |
74 | neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976) | 2.77769859 |
75 | positive regulation of cation channel activity (GO:2001259) | 2.77086625 |
76 | regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510) | 2.76093645 |
77 | cardiac muscle hypertrophy in response to stress (GO:0014898) | 2.75635520 |
78 | muscle hypertrophy in response to stress (GO:0003299) | 2.75635520 |
79 | cardiac muscle adaptation (GO:0014887) | 2.75635520 |
80 | response to epinephrine (GO:0071871) | 2.75114928 |
81 | cilium or flagellum-dependent cell motility (GO:0001539) | 2.70614562 |
82 | negative regulation of potassium ion transmembrane transport (GO:1901380) | 2.70323917 |
83 | negative regulation of calcium ion transmembrane transport (GO:1903170) | 2.68632860 |
84 | negative regulation of calcium ion transmembrane transporter activity (GO:1901020) | 2.68632860 |
85 | cerebral cortex radially oriented cell migration (GO:0021799) | 2.68056868 |
86 | atrial septum morphogenesis (GO:0060413) | 2.68026363 |
87 | epithelial cilium movement (GO:0003351) | 2.65396261 |
88 | positive regulation of cardiac muscle tissue growth (GO:0055023) | 2.64111906 |
89 | regulation of acyl-CoA biosynthetic process (GO:0050812) | 2.63836343 |
90 | positive regulation of heart contraction (GO:0045823) | 2.63596868 |
91 | regulation of cation channel activity (GO:2001257) | 2.62101078 |
92 | negative regulation of heart rate (GO:0010459) | 2.58349336 |
93 | relaxation of smooth muscle (GO:0044557) | 2.58115297 |
94 | regulation of voltage-gated calcium channel activity (GO:1901385) | 2.58072564 |
95 | negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315) | 2.57471255 |
96 | cilium movement (GO:0003341) | 2.57421921 |
97 | sodium ion export (GO:0071436) | 2.57360677 |
98 | microtubule polymerization or depolymerization (GO:0031109) | 2.53941054 |
99 | motile cilium assembly (GO:0044458) | 2.52801015 |
100 | regulation of heart rate by cardiac conduction (GO:0086091) | 2.51801295 |
Rank | Gene Set | Z-score |
---|---|---|
1 | GBX2_23144817_ChIP-Seq_PC3_Human | 3.75565583 |
2 | EZH2_22144423_ChIP-Seq_EOC_Human | 3.65122778 |
3 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 2.83987814 |
4 | TAF15_26573619_Chip-Seq_HEK293_Human | 2.63632606 |
5 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 2.60965923 |
6 | VDR_22108803_ChIP-Seq_LS180_Human | 2.53766375 |
7 | FUS_26573619_Chip-Seq_HEK293_Human | 2.49764961 |
8 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 2.46695265 |
9 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 2.45478042 |
10 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 2.43290902 |
11 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 2.29661601 |
12 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 2.24405353 |
13 | SMAD4_21799915_ChIP-Seq_A2780_Human | 2.22001103 |
14 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 2.18495694 |
15 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 2.09573813 |
16 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 2.09485284 |
17 | IGF1R_20145208_ChIP-Seq_DFB_Human | 2.09432108 |
18 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 2.08811108 |
19 | P300_19829295_ChIP-Seq_ESCs_Human | 2.07584001 |
20 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 2.05590280 |
21 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 2.03571886 |
22 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.97584777 |
23 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.96897257 |
24 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.96398559 |
25 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.87063638 |
26 | * STAT3_23295773_ChIP-Seq_U87_Human | 1.83745503 |
27 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.80765970 |
28 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.77098835 |
29 | EWS_26573619_Chip-Seq_HEK293_Human | 1.75945595 |
30 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.73404883 |
31 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.72633935 |
32 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.70145361 |
33 | TCF4_23295773_ChIP-Seq_U87_Human | 1.68926470 |
34 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.68487110 |
35 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.64296060 |
36 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.64071068 |
37 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.63027124 |
38 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.61530202 |
39 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 1.59290951 |
40 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.56582492 |
41 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.56582492 |
42 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.56293575 |
43 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.53796734 |
44 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 1.52563677 |
45 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.50509082 |
46 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.45331157 |
47 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 1.44768234 |
48 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 1.41168417 |
49 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.40495673 |
50 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.40315663 |
51 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.39251059 |
52 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.39251059 |
53 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.39019923 |
54 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 1.37365853 |
55 | AR_25329375_ChIP-Seq_VCAP_Human | 1.36299753 |
56 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 1.35066433 |
57 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.34299357 |
58 | RUNX2_22187159_ChIP-Seq_PCA_Human | 1.29276686 |
59 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 1.28177505 |
60 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.28125551 |
61 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 1.27791264 |
62 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 1.26026656 |
63 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.25913649 |
64 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.25628161 |
65 | TCF4_22108803_ChIP-Seq_LS180_Human | 1.25090602 |
66 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.23170968 |
67 | FOXM1_26456572_ChIP-Seq_MCF-7_Human | 1.22312203 |
68 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 1.21447343 |
69 | SOX9_26525672_Chip-Seq_HEART_Mouse | 1.20805163 |
70 | REST_21632747_ChIP-Seq_MESCs_Mouse | 1.19907825 |
71 | LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.18942282 |
72 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.18867015 |
73 | TBL1_22424771_ChIP-Seq_293T_Human | 1.17507230 |
74 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.15319261 |
75 | SMAD4_21741376_ChIP-Seq_EPCs_Human | 1.14977680 |
76 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.13732101 |
77 | E2F1_18555785_Chip-Seq_ESCs_Mouse | 1.13676885 |
78 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 1.13440575 |
79 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.12122507 |
80 | CEBPB_26923725_Chip-Seq_MESODERM_Mouse | 1.12066327 |
81 | FLI1_21867929_ChIP-Seq_TH2_Mouse | 1.11723048 |
82 | TAL1_26923725_Chip-Seq_HPCs_Mouse | 1.11453686 |
83 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 1.10395301 |
84 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 1.09753788 |
85 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 1.09549449 |
86 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.09468830 |
87 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.08446332 |
88 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 1.07721708 |
89 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 1.07656092 |
90 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.07535502 |
91 | TP53_16413492_ChIP-PET_HCT116_Human | 1.07395870 |
92 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 1.06120506 |
93 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 1.06120506 |
94 | WT1_19549856_ChIP-ChIP_CCG9911_Human | 1.05442429 |
95 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 1.04132326 |
96 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.03987899 |
97 | TP53_18474530_ChIP-ChIP_U2OS_Human | 1.03584843 |
98 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 1.03064730 |
99 | DROSHA_22980978_ChIP-Seq_HELA_Human | 1.02549038 |
100 | P53_22387025_ChIP-Seq_ESCs_Mouse | 1.02230917 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0004084_abnormal_cardiac_muscle | 4.96932911 |
2 | MP0002837_dystrophic_cardiac_calcinosis | 4.43385233 |
3 | MP0004215_abnormal_myocardial_fiber | 4.35861599 |
4 | MP0004036_abnormal_muscle_relaxation | 3.18005165 |
5 | MP0000751_myopathy | 2.92596238 |
6 | MP0008775_abnormal_heart_ventricle | 2.75261435 |
7 | MP0003137_abnormal_impulse_conducting | 2.54022705 |
8 | MP0004510_myositis | 2.44583685 |
9 | MP0004484_altered_response_of | 2.44575519 |
10 | MP0002972_abnormal_cardiac_muscle | 2.23871251 |
11 | MP0005330_cardiomyopathy | 2.23180743 |
12 | MP0004085_abnormal_heartbeat | 2.20811716 |
13 | MP0003880_abnormal_central_pattern | 2.16801255 |
14 | MP0003646_muscle_fatigue | 2.09932940 |
15 | MP0001984_abnormal_olfaction | 1.84735929 |
16 | MP0009046_muscle_twitch | 1.84555977 |
17 | MP0004859_abnormal_synaptic_plasticity | 1.84379220 |
18 | MP0005620_abnormal_muscle_contractility | 1.80902276 |
19 | MP0004145_abnormal_muscle_electrophysio | 1.78367415 |
20 | MP0001486_abnormal_startle_reflex | 1.77673920 |
21 | MP0000749_muscle_degeneration | 1.74572805 |
22 | MP0009745_abnormal_behavioral_response | 1.67817502 |
23 | MP0005670_abnormal_white_adipose | 1.67067521 |
24 | MP0002127_abnormal_cardiovascular_syste | 1.59065450 |
25 | MP0005385_cardiovascular_system_phenoty | 1.57733167 |
26 | MP0001544_abnormal_cardiovascular_syste | 1.57733167 |
27 | MP0002272_abnormal_nervous_system | 1.54525054 |
28 | MP0006138_congestive_heart_failure | 1.52957183 |
29 | MP0002735_abnormal_chemical_nociception | 1.50658787 |
30 | MP0002064_seizures | 1.48780229 |
31 | MP0002234_abnormal_pharynx_morphology | 1.44747977 |
32 | MP0010630_abnormal_cardiac_muscle | 1.42624285 |
33 | MP0003635_abnormal_synaptic_transmissio | 1.42477299 |
34 | MP0008057_abnormal_DNA_replication | 1.39377222 |
35 | MP0004087_abnormal_muscle_fiber | 1.34993136 |
36 | MP0004130_abnormal_muscle_cell | 1.30680140 |
37 | MP0004147_increased_porphyrin_level | 1.30547042 |
38 | MP0005646_abnormal_pituitary_gland | 1.30041101 |
39 | MP0002572_abnormal_emotion/affect_behav | 1.26985020 |
40 | MP0001968_abnormal_touch/_nociception | 1.24960077 |
41 | MP0006276_abnormal_autonomic_nervous | 1.24902008 |
42 | MP0005187_abnormal_penis_morphology | 1.23941889 |
43 | MP0000569_abnormal_digit_pigmentation | 1.23259138 |
44 | MP0005551_abnormal_eye_electrophysiolog | 1.22676735 |
45 | MP0001501_abnormal_sleep_pattern | 1.21865280 |
46 | MP0002063_abnormal_learning/memory/cond | 1.20211166 |
47 | MP0002102_abnormal_ear_morphology | 1.19570155 |
48 | MP0002736_abnormal_nociception_after | 1.16900046 |
49 | MP0002269_muscular_atrophy | 1.16077703 |
50 | MP0002106_abnormal_muscle_physiology | 1.14881292 |
51 | MP0005386_behavior/neurological_phenoty | 1.14315839 |
52 | MP0004924_abnormal_behavior | 1.14315839 |
53 | MP0002638_abnormal_pupillary_reflex | 1.12088434 |
54 | MP0006072_abnormal_retinal_apoptosis | 1.12028223 |
55 | MP0005253_abnormal_eye_physiology | 1.10851411 |
56 | MP0010368_abnormal_lymphatic_system | 1.09195296 |
57 | MP0002067_abnormal_sensory_capabilities | 1.04755352 |
58 | MP0005423_abnormal_somatic_nervous | 0.99875097 |
59 | MP0002734_abnormal_mechanical_nocicepti | 0.98796095 |
60 | MP0008877_abnormal_DNA_methylation | 0.97607839 |
61 | MP0000778_abnormal_nervous_system | 0.97081350 |
62 | MP0005369_muscle_phenotype | 0.96296573 |
63 | MP0004270_analgesia | 0.93389156 |
64 | MP0003937_abnormal_limbs/digits/tail_de | 0.93293057 |
65 | MP0001529_abnormal_vocalization | 0.91455573 |
66 | MP0001970_abnormal_pain_threshold | 0.90707821 |
67 | MP0002557_abnormal_social/conspecific_i | 0.89675134 |
68 | MP0000631_abnormal_neuroendocrine_gland | 0.87115024 |
69 | MP0008569_lethality_at_weaning | 0.85924744 |
70 | MP0000383_abnormal_hair_follicle | 0.84406532 |
71 | MP0001485_abnormal_pinna_reflex | 0.83256664 |
72 | MP0003698_abnormal_male_reproductive | 0.82263104 |
73 | MP0005165_increased_susceptibility_to | 0.79879418 |
74 | MP0004043_abnormal_pH_regulation | 0.79832960 |
75 | MP0000747_muscle_weakness | 0.79344942 |
76 | MP0000266_abnormal_heart_morphology | 0.78661373 |
77 | MP0001177_atelectasis | 0.78496650 |
78 | MP0003136_yellow_coat_color | 0.75356462 |
79 | MP0005248_abnormal_Harderian_gland | 0.74568490 |
80 | MP0005410_abnormal_fertilization | 0.73876611 |
81 | MP0002882_abnormal_neuron_morphology | 0.72265836 |
82 | MP0000427_abnormal_hair_cycle | 0.71727773 |
83 | MP0002733_abnormal_thermal_nociception | 0.70892581 |
84 | MP0001963_abnormal_hearing_physiology | 0.68702953 |
85 | MP0003890_abnormal_embryonic-extraembry | 0.68502062 |
86 | MP0001299_abnormal_eye_distance/ | 0.68247883 |
87 | MP0001929_abnormal_gametogenesis | 0.67267271 |
88 | MP0003633_abnormal_nervous_system | 0.66275058 |
89 | MP0002184_abnormal_innervation | 0.65709327 |
90 | MP0003787_abnormal_imprinting | 0.64447700 |
91 | MP0002066_abnormal_motor_capabilities/c | 0.63745734 |
92 | MP0005266_abnormal_metabolism | 0.63310198 |
93 | MP0010386_abnormal_urinary_bladder | 0.62957455 |
94 | MP0001346_abnormal_lacrimal_gland | 0.62828260 |
95 | MP0000230_abnormal_systemic_arterial | 0.62793805 |
96 | MP0002249_abnormal_larynx_morphology | 0.60864473 |
97 | MP0002752_abnormal_somatic_nervous | 0.60621983 |
98 | MP0002229_neurodegeneration | 0.59016397 |
99 | MP0003283_abnormal_digestive_organ | 0.58479841 |
100 | MP0003950_abnormal_plasma_membrane | 0.58226762 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Bundle branch block (HP:0011710) | 6.83188458 |
2 | Sudden death (HP:0001699) | 6.76188439 |
3 | Atrial fibrillation (HP:0005110) | 5.76291094 |
4 | Primary atrial arrhythmia (HP:0001692) | 5.28781111 |
5 | Syncope (HP:0001279) | 5.22001379 |
6 | Supraventricular tachycardia (HP:0004755) | 5.03767108 |
7 | Supraventricular arrhythmia (HP:0005115) | 4.88275609 |
8 | Ventricular tachycardia (HP:0004756) | 4.84339976 |
9 | Right ventricular cardiomyopathy (HP:0011663) | 4.32029451 |
10 | Abnormality of the calf musculature (HP:0001430) | 4.12638184 |
11 | Heart block (HP:0012722) | 4.11013150 |
12 | Lipoatrophy (HP:0100578) | 3.91748460 |
13 | Abnormal atrioventricular conduction (HP:0005150) | 3.66361698 |
14 | Focal motor seizures (HP:0011153) | 3.62122154 |
15 | Ventricular arrhythmia (HP:0004308) | 3.52837809 |
16 | Left ventricular hypertrophy (HP:0001712) | 3.40722449 |
17 | Calf muscle hypertrophy (HP:0008981) | 3.34433148 |
18 | Dilated cardiomyopathy (HP:0001644) | 3.26264642 |
19 | Subaortic stenosis (HP:0001682) | 3.19769121 |
20 | Abnormality of the left ventricular outflow tract (HP:0011103) | 3.19769121 |
21 | Hyporeflexia of lower limbs (HP:0002600) | 3.16423652 |
22 | Prolonged QT interval (HP:0001657) | 3.05872179 |
23 | Hyperventilation (HP:0002883) | 2.95952471 |
24 | Muscle fiber splitting (HP:0003555) | 2.91424355 |
25 | Abnormal EKG (HP:0003115) | 2.88286391 |
26 | Muscle hypertrophy of the lower extremities (HP:0008968) | 2.87829484 |
27 | Asymmetric septal hypertrophy (HP:0001670) | 2.87401352 |
28 | Central scotoma (HP:0000603) | 2.85373233 |
29 | Atrioventricular block (HP:0001678) | 2.83975839 |
30 | Febrile seizures (HP:0002373) | 2.75693072 |
31 | Myokymia (HP:0002411) | 2.73923214 |
32 | Tubulointerstitial nephritis (HP:0001970) | 2.71460078 |
33 | Chronic hepatic failure (HP:0100626) | 2.70683994 |
34 | Palpitations (HP:0001962) | 2.63208080 |
35 | Ventricular fibrillation (HP:0001663) | 2.62832390 |
36 | Atonic seizures (HP:0010819) | 2.60811156 |
37 | Gaze-evoked nystagmus (HP:0000640) | 2.52245603 |
38 | Focal seizures (HP:0007359) | 2.48487131 |
39 | Rimmed vacuoles (HP:0003805) | 2.40673085 |
40 | Medial flaring of the eyebrow (HP:0010747) | 2.37650054 |
41 | Nephronophthisis (HP:0000090) | 2.35341642 |
42 | EMG: neuropathic changes (HP:0003445) | 2.35002947 |
43 | Abnormal ciliary motility (HP:0012262) | 2.32080939 |
44 | Abnormal respiratory motile cilium physiology (HP:0012261) | 2.27041955 |
45 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 2.26665017 |
46 | Absent/shortened dynein arms (HP:0200106) | 2.26665017 |
47 | Broad-based gait (HP:0002136) | 2.26053526 |
48 | Dialeptic seizures (HP:0011146) | 2.23554762 |
49 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 2.23179529 |
50 | Pancreatic cysts (HP:0001737) | 2.21413513 |
51 | Pancreatic fibrosis (HP:0100732) | 2.21393630 |
52 | Congenital malformation of the right heart (HP:0011723) | 2.16046726 |
53 | Double outlet right ventricle (HP:0001719) | 2.16046726 |
54 | True hermaphroditism (HP:0010459) | 2.12602044 |
55 | Drooling (HP:0002307) | 2.07868437 |
56 | EMG: myopathic abnormalities (HP:0003458) | 2.07840306 |
57 | Absence seizures (HP:0002121) | 2.06138483 |
58 | Steppage gait (HP:0003376) | 2.05616377 |
59 | Abnormality of the renal cortex (HP:0011035) | 2.02178634 |
60 | Gait imbalance (HP:0002141) | 2.00617708 |
61 | Abnormality of the renal medulla (HP:0100957) | 2.00424741 |
62 | Abnormal respiratory epithelium morphology (HP:0012253) | 1.95531765 |
63 | Abnormal respiratory motile cilium morphology (HP:0005938) | 1.95531765 |
64 | Congenital primary aphakia (HP:0007707) | 1.95022454 |
65 | Areflexia of lower limbs (HP:0002522) | 1.91955134 |
66 | Genital tract atresia (HP:0001827) | 1.90687497 |
67 | Progressive cerebellar ataxia (HP:0002073) | 1.90174950 |
68 | Decreased number of large peripheral myelinated nerve fibers (HP:0003387) | 1.88197864 |
69 | Vaginal atresia (HP:0000148) | 1.87525114 |
70 | Action tremor (HP:0002345) | 1.86989489 |
71 | Abnormality of midbrain morphology (HP:0002418) | 1.84558952 |
72 | Molar tooth sign on MRI (HP:0002419) | 1.84558952 |
73 | Scotoma (HP:0000575) | 1.83043630 |
74 | Excessive salivation (HP:0003781) | 1.79783354 |
75 | Ragged-red muscle fibers (HP:0003200) | 1.79380513 |
76 | Attenuation of retinal blood vessels (HP:0007843) | 1.79120535 |
77 | Rhinitis (HP:0012384) | 1.77690602 |
78 | Type II lissencephaly (HP:0007260) | 1.76815726 |
79 | Nephrogenic diabetes insipidus (HP:0009806) | 1.74161815 |
80 | Volvulus (HP:0002580) | 1.72243957 |
81 | Poor coordination (HP:0002370) | 1.70496410 |
82 | Hypoplastic left heart (HP:0004383) | 1.68343879 |
83 | Absent speech (HP:0001344) | 1.66992413 |
84 | Dysmetric saccades (HP:0000641) | 1.66371252 |
85 | Cystic liver disease (HP:0006706) | 1.65079810 |
86 | Genetic anticipation (HP:0003743) | 1.65056354 |
87 | Hemiparesis (HP:0001269) | 1.65046847 |
88 | Bradycardia (HP:0001662) | 1.64852169 |
89 | Abnormality of macular pigmentation (HP:0008002) | 1.63920161 |
90 | Toxemia of pregnancy (HP:0100603) | 1.62896438 |
91 | Abnormality of the corticospinal tract (HP:0002492) | 1.59744648 |
92 | Epileptic encephalopathy (HP:0200134) | 1.59723104 |
93 | Abnormality of the foot musculature (HP:0001436) | 1.58598207 |
94 | Abnormality of the astrocytes (HP:0100707) | 1.57952937 |
95 | Astrocytoma (HP:0009592) | 1.57952937 |
96 | Postaxial foot polydactyly (HP:0001830) | 1.57374797 |
97 | Generalized tonic-clonic seizures (HP:0002069) | 1.56600270 |
98 | Abnormal drinking behavior (HP:0030082) | 1.55971921 |
99 | Polydipsia (HP:0001959) | 1.55971921 |
100 | Preaxial foot polydactyly (HP:0001841) | 1.55335341 |
Rank | Gene Set | Z-score |
---|---|---|
1 | OBSCN | 3.77356830 |
2 | FRK | 3.61806311 |
3 | MYLK | 3.26271521 |
4 | EPHA4 | 3.10065521 |
5 | DMPK | 2.84966287 |
6 | PLK4 | 2.56482865 |
7 | WNK3 | 2.35673933 |
8 | STK38L | 2.33134867 |
9 | MAP4K2 | 2.30207450 |
10 | MARK1 | 2.26407477 |
11 | PNCK | 1.89573020 |
12 | PINK1 | 1.88510454 |
13 | MAP3K4 | 1.82409931 |
14 | BMPR1B | 1.80649349 |
15 | MKNK2 | 1.74960328 |
16 | CASK | 1.66794658 |
17 | PIK3CA | 1.59709345 |
18 | TTN | 1.59044474 |
19 | PLK2 | 1.53381024 |
20 | PAK3 | 1.53195718 |
21 | LATS1 | 1.50395482 |
22 | ACVR1B | 1.47090933 |
23 | INSRR | 1.45965313 |
24 | FLT3 | 1.45625202 |
25 | NTRK3 | 1.45163580 |
26 | PKN2 | 1.44065137 |
27 | ERBB3 | 1.43606117 |
28 | MAPK13 | 1.40299955 |
29 | TRPM7 | 1.39455460 |
30 | CAMK2A | 1.32138720 |
31 | BRSK2 | 1.30306525 |
32 | PRKCE | 1.30256629 |
33 | GRK7 | 1.24426126 |
34 | CAMK1 | 1.22357722 |
35 | AKT3 | 1.17847497 |
36 | TNIK | 1.15184757 |
37 | CAMK2D | 1.12573548 |
38 | CCNB1 | 1.07779083 |
39 | CAMK4 | 1.06717658 |
40 | BRD4 | 1.00928598 |
41 | STK38 | 1.00385743 |
42 | BCR | 0.97579045 |
43 | UHMK1 | 0.91635520 |
44 | DAPK2 | 0.88713068 |
45 | MKNK1 | 0.86353826 |
46 | TIE1 | 0.83537207 |
47 | MINK1 | 0.83213212 |
48 | TRIM28 | 0.81133695 |
49 | NUAK1 | 0.80789530 |
50 | ROCK1 | 0.80655748 |
51 | PRKAA1 | 0.80448123 |
52 | CAMKK2 | 0.73656264 |
53 | PAK6 | 0.73118529 |
54 | CAMK2B | 0.69189186 |
55 | WEE1 | 0.68559048 |
56 | NTRK2 | 0.68512997 |
57 | PKN1 | 0.66805373 |
58 | CDC7 | 0.64861787 |
59 | SGK2 | 0.63008928 |
60 | MAP2K7 | 0.62662911 |
61 | PRKCG | 0.62375048 |
62 | PRKAA2 | 0.61074263 |
63 | WNK1 | 0.59145717 |
64 | CDK3 | 0.58767999 |
65 | PTK2B | 0.58479830 |
66 | ADRBK1 | 0.57510298 |
67 | ZAK | 0.56966991 |
68 | MUSK | 0.55858106 |
69 | MAP3K7 | 0.55656605 |
70 | PRKG1 | 0.53812478 |
71 | PRKACA | 0.53718630 |
72 | PHKG2 | 0.53226898 |
73 | PHKG1 | 0.53226898 |
74 | NEK9 | 0.52715003 |
75 | PRKD1 | 0.52608169 |
76 | OXSR1 | 0.50731860 |
77 | FGFR2 | 0.49183472 |
78 | RPS6KA3 | 0.48002129 |
79 | CDK5 | 0.47130988 |
80 | ROCK2 | 0.46684912 |
81 | ATM | 0.46280217 |
82 | STK4 | 0.44419298 |
83 | DYRK1A | 0.43190566 |
84 | STK11 | 0.43008233 |
85 | CSNK1G1 | 0.42987268 |
86 | NLK | 0.42313264 |
87 | PRKACB | 0.41434845 |
88 | STK39 | 0.41385675 |
89 | NEK1 | 0.40580025 |
90 | CAMK1G | 0.39174334 |
91 | SGK223 | 0.38055085 |
92 | SGK494 | 0.38055085 |
93 | PIK3CG | 0.37573013 |
94 | SGK1 | 0.37305942 |
95 | MAPK15 | 0.36343217 |
96 | ADRBK2 | 0.34941780 |
97 | CSNK1G2 | 0.34683390 |
98 | PRKACG | 0.34636956 |
99 | LATS2 | 0.34434836 |
100 | TTK | 0.33810143 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 3.41777448 |
2 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 3.16327650 |
3 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 2.96708631 |
4 | Nicotine addiction_Homo sapiens_hsa05033 | 2.66651130 |
5 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 2.44956896 |
6 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 2.23489115 |
7 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 2.23087135 |
8 | Taste transduction_Homo sapiens_hsa04742 | 2.10507655 |
9 | Circadian entrainment_Homo sapiens_hsa04713 | 2.09781329 |
10 | Propanoate metabolism_Homo sapiens_hsa00640 | 2.05685238 |
11 | Morphine addiction_Homo sapiens_hsa05032 | 2.03431508 |
12 | GABAergic synapse_Homo sapiens_hsa04727 | 1.92993947 |
13 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 1.90827149 |
14 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.81747475 |
15 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.79285032 |
16 | Insulin secretion_Homo sapiens_hsa04911 | 1.78109195 |
17 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 1.74832445 |
18 | Renin secretion_Homo sapiens_hsa04924 | 1.74776623 |
19 | Glutamatergic synapse_Homo sapiens_hsa04724 | 1.63988288 |
20 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.58242607 |
21 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.57853545 |
22 | Circadian rhythm_Homo sapiens_hsa04710 | 1.56691596 |
23 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 1.50558846 |
24 | Salivary secretion_Homo sapiens_hsa04970 | 1.48619475 |
25 | Phototransduction_Homo sapiens_hsa04744 | 1.45822875 |
26 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.35097143 |
27 | Amphetamine addiction_Homo sapiens_hsa05031 | 1.32014489 |
28 | Olfactory transduction_Homo sapiens_hsa04740 | 1.19768098 |
29 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.19349368 |
30 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.18470384 |
31 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.14057839 |
32 | Dopaminergic synapse_Homo sapiens_hsa04728 | 1.09008788 |
33 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 1.07053733 |
34 | Regulation of autophagy_Homo sapiens_hsa04140 | 1.06019426 |
35 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.03561065 |
36 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.02520420 |
37 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.99566808 |
38 | Cocaine addiction_Homo sapiens_hsa05030 | 0.99094073 |
39 | Cholinergic synapse_Homo sapiens_hsa04725 | 0.98398800 |
40 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.96548054 |
41 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.96488405 |
42 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.95445873 |
43 | Parkinsons disease_Homo sapiens_hsa05012 | 0.93849789 |
44 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.93591450 |
45 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.93234062 |
46 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.92920300 |
47 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 0.91780446 |
48 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.91652821 |
49 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.87360020 |
50 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.84345577 |
51 | Homologous recombination_Homo sapiens_hsa03440 | 0.84332986 |
52 | Gap junction_Homo sapiens_hsa04540 | 0.84146748 |
53 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.81514410 |
54 | Huntingtons disease_Homo sapiens_hsa05016 | 0.81059007 |
55 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.80022935 |
56 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.79241263 |
57 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.79161531 |
58 | Long-term potentiation_Homo sapiens_hsa04720 | 0.77449253 |
59 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.73130183 |
60 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.71020386 |
61 | Lysine degradation_Homo sapiens_hsa00310 | 0.70544862 |
62 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.70293731 |
63 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.68896329 |
64 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.68499856 |
65 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.68239573 |
66 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.67554492 |
67 | ABC transporters_Homo sapiens_hsa02010 | 0.65972958 |
68 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.65729979 |
69 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.65398254 |
70 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.65237948 |
71 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.65076905 |
72 | Alzheimers disease_Homo sapiens_hsa05010 | 0.64514666 |
73 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.61433683 |
74 | Purine metabolism_Homo sapiens_hsa00230 | 0.61020673 |
75 | Long-term depression_Homo sapiens_hsa04730 | 0.60409393 |
76 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.55314933 |
77 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.54640292 |
78 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.52597489 |
79 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.50666579 |
80 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.50419539 |
81 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.50345004 |
82 | Tight junction_Homo sapiens_hsa04530 | 0.50311072 |
83 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.49521223 |
84 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.49060059 |
85 | Melanogenesis_Homo sapiens_hsa04916 | 0.48043623 |
86 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.47786439 |
87 | Alcoholism_Homo sapiens_hsa05034 | 0.47210765 |
88 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.47082630 |
89 | Bile secretion_Homo sapiens_hsa04976 | 0.46399311 |
90 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.46049496 |
91 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.46010928 |
92 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.45644057 |
93 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.43766159 |
94 | Peroxisome_Homo sapiens_hsa04146 | 0.42771797 |
95 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.42273175 |
96 | Adherens junction_Homo sapiens_hsa04520 | 0.39690586 |
97 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.39529160 |
98 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.37667497 |
99 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.37622672 |
100 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.36759721 |