DPY19L2P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)9.40751809
2axonemal dynein complex assembly (GO:0070286)6.62523625
3motile cilium assembly (GO:0044458)6.50049188
4cilium movement (GO:0003341)6.46277886
5epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.43090810
6epithelial cilium movement (GO:0003351)5.51252260
7axoneme assembly (GO:0035082)5.23667648
8tryptophan catabolic process (GO:0006569)4.08517032
9indole-containing compound catabolic process (GO:0042436)4.08517032
10indolalkylamine catabolic process (GO:0046218)4.08517032
11cilium organization (GO:0044782)4.00392685
12left/right axis specification (GO:0070986)3.96387873
13retinal cone cell development (GO:0046549)3.90343526
14cilium assembly (GO:0042384)3.87352592
15interkinetic nuclear migration (GO:0022027)3.80658645
16neural tube formation (GO:0001841)3.78243803
17indolalkylamine metabolic process (GO:0006586)3.75090187
18kynurenine metabolic process (GO:0070189)3.73579134
19regulation of cilium movement (GO:0003352)3.68180053
20ventricular system development (GO:0021591)3.66717582
21response to pheromone (GO:0019236)3.62316820
22tryptophan metabolic process (GO:0006568)3.62126983
23monoubiquitinated protein deubiquitination (GO:0035520)3.60999161
24positive regulation of developmental pigmentation (GO:0048087)3.52724472
25photoreceptor cell maintenance (GO:0045494)3.49748543
26snRNA transcription (GO:0009301)3.49074467
27meiotic chromosome segregation (GO:0045132)3.47209048
28intraciliary transport (GO:0042073)3.37863492
29establishment of protein localization to Golgi (GO:0072600)3.32386075
30detection of light stimulus involved in sensory perception (GO:0050962)3.27576849
31detection of light stimulus involved in visual perception (GO:0050908)3.27576849
32cellular component assembly involved in morphogenesis (GO:0010927)3.26747683
33protein localization to cilium (GO:0061512)3.25145933
34cilium morphogenesis (GO:0060271)3.24655795
35regulation of pigment cell differentiation (GO:0050932)3.17693519
36microtubule polymerization or depolymerization (GO:0031109)3.16977016
37rRNA catabolic process (GO:0016075)3.15923981
38regulation of hippo signaling (GO:0035330)3.14898902
39protein K48-linked deubiquitination (GO:0071108)3.13859718
40cytoplasmic mRNA processing body assembly (GO:0033962)3.13209296
41left/right pattern formation (GO:0060972)3.13102101
42behavioral response to nicotine (GO:0035095)3.10305837
43fucose catabolic process (GO:0019317)3.07777382
44L-fucose metabolic process (GO:0042354)3.07777382
45L-fucose catabolic process (GO:0042355)3.07777382
46regulation of establishment of cell polarity (GO:2000114)3.04623974
47regulation of sarcomere organization (GO:0060297)3.03732025
48retinal rod cell development (GO:0046548)3.02174556
49sperm motility (GO:0030317)3.00671189
50negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.00071248
51negative regulation of translation, ncRNA-mediated (GO:0040033)3.00071248
52regulation of translation, ncRNA-mediated (GO:0045974)3.00071248
53microtubule bundle formation (GO:0001578)2.96849521
54microtubule depolymerization (GO:0007019)2.88188536
55protein polyglutamylation (GO:0018095)2.87879171
56centriole replication (GO:0007099)2.87323800
57cellular biogenic amine catabolic process (GO:0042402)2.85550863
58amine catabolic process (GO:0009310)2.85550863
59indole-containing compound metabolic process (GO:0042430)2.81240596
60detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.78529336
61centriole assembly (GO:0098534)2.76475390
62protein K11-linked deubiquitination (GO:0035871)2.75998577
63G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.71187901
64reciprocal DNA recombination (GO:0035825)2.70694190
65reciprocal meiotic recombination (GO:0007131)2.70694190
66DNA methylation involved in gamete generation (GO:0043046)2.70212179
67regulation of gene silencing by RNA (GO:0060966)2.66385335
68regulation of posttranscriptional gene silencing (GO:0060147)2.66385335
69regulation of gene silencing by miRNA (GO:0060964)2.66385335
70piRNA metabolic process (GO:0034587)2.63877785
71histone H3-K9 methylation (GO:0051567)2.63765013
72centrosome duplication (GO:0051298)2.63569042
73reflex (GO:0060004)2.63410324
74recombinational repair (GO:0000725)2.62258007
75double-strand break repair via homologous recombination (GO:0000724)2.60472720
76benzene-containing compound metabolic process (GO:0042537)2.60020891
77microtubule anchoring (GO:0034453)2.57211285
78NAD biosynthetic process (GO:0009435)2.53858059
79spinal cord motor neuron differentiation (GO:0021522)2.53151552
80microtubule-based movement (GO:0007018)2.52209758
81membrane depolarization during action potential (GO:0086010)2.51510622
82negative regulation of sodium ion transport (GO:0010766)2.50984127
83negative regulation of cytosolic calcium ion concentration (GO:0051481)2.49564757
84lipid translocation (GO:0034204)2.47531958
85phospholipid translocation (GO:0045332)2.47531958
86serotonin metabolic process (GO:0042428)2.45452748
87retina layer formation (GO:0010842)2.45121640
88microtubule severing (GO:0051013)2.44462945
89cellular ketone body metabolic process (GO:0046950)2.43277134
90cell projection assembly (GO:0030031)2.43070616
91oxidative demethylation (GO:0070989)2.40912093
92regulation of establishment or maintenance of cell polarity (GO:0032878)2.39984570
93cellular response to sterol (GO:0036315)2.39493230
94protein K63-linked deubiquitination (GO:0070536)2.36857754
95cellular response to ethanol (GO:0071361)2.35391412
96protein targeting to Golgi (GO:0000042)2.35193743
97gamma-aminobutyric acid transport (GO:0015812)2.34826248
98behavioral response to ethanol (GO:0048149)2.34416517
99gene silencing by RNA (GO:0031047)2.33711327
100neuronal action potential (GO:0019228)2.33653541

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* GBX2_23144817_ChIP-Seq_PC3_Human3.31870046
2IGF1R_20145208_ChIP-Seq_DFB_Human3.13635470
3ZNF274_21170338_ChIP-Seq_K562_Hela3.12506942
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.11812125
5VDR_22108803_ChIP-Seq_LS180_Human3.10567772
6EZH2_22144423_ChIP-Seq_EOC_Human3.07609278
7TAF15_26573619_Chip-Seq_HEK293_Human2.58440325
8CTBP2_25329375_ChIP-Seq_LNCAP_Human2.49860095
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.48477690
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.39891033
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.24317666
12SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.22681632
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.21107382
14PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.21038795
15DROSHA_22980978_ChIP-Seq_HELA_Human2.11281505
16CTBP1_25329375_ChIP-Seq_LNCAP_Human2.07522537
17STAT3_23295773_ChIP-Seq_U87_Human2.07348551
18BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.05664178
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.04275213
20AR_21572438_ChIP-Seq_LNCaP_Human2.02034376
21FUS_26573619_Chip-Seq_HEK293_Human2.01304463
22EWS_26573619_Chip-Seq_HEK293_Human1.97400297
23* ER_23166858_ChIP-Seq_MCF-7_Human1.96859898
24SMAD4_21799915_ChIP-Seq_A2780_Human1.95652366
25AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.95065968
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.93138649
27PIAS1_25552417_ChIP-Seq_VCAP_Human1.83389445
28TCF4_23295773_ChIP-Seq_U87_Human1.81659584
29P300_19829295_ChIP-Seq_ESCs_Human1.80440814
30IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.74570739
31CBP_20019798_ChIP-Seq_JUKART_Human1.74570739
32SALL1_21062744_ChIP-ChIP_HESCs_Human1.70587170
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.67998818
34UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.65262854
35NR3C1_21868756_ChIP-Seq_MCF10A_Human1.64611641
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.63638254
37BCAT_22108803_ChIP-Seq_LS180_Human1.57055247
38TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.54352379
39POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.54352379
40AR_25329375_ChIP-Seq_VCAP_Human1.52392675
41FLI1_27457419_Chip-Seq_LIVER_Mouse1.51309881
42MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.48147512
43EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.47803621
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.46475468
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44714654
46TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.42566362
47PRDM14_20953172_ChIP-Seq_ESCs_Human1.41907178
48TOP2B_26459242_ChIP-Seq_MCF-7_Human1.41460033
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.41386761
50IRF1_19129219_ChIP-ChIP_H3396_Human1.32104753
51* RUNX2_22187159_ChIP-Seq_PCA_Human1.31997142
52TP53_16413492_ChIP-PET_HCT116_Human1.30992966
53TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30422014
54ARNT_22903824_ChIP-Seq_MCF-7_Human1.30156841
55FLI1_21867929_ChIP-Seq_TH2_Mouse1.26958074
56REST_21632747_ChIP-Seq_MESCs_Mouse1.26462823
57AHR_22903824_ChIP-Seq_MCF-7_Human1.25713884
58TCF4_22108803_ChIP-Seq_LS180_Human1.22906124
59KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22852940
60TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21437106
61PCGF2_27294783_Chip-Seq_ESCs_Mouse1.19613209
62SMAD4_21741376_ChIP-Seq_EPCs_Human1.18383737
63SOX2_21211035_ChIP-Seq_LN229_Gbm1.16401968
64WDR5_24793694_ChIP-Seq_LNCAP_Human1.16062956
65TP53_22573176_ChIP-Seq_HFKS_Human1.13480698
66FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10920136
67RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09284653
68EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.07965972
69SCL_19346495_ChIP-Seq_HPC-7_Human1.07653072
70TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.06774089
71AR_19668381_ChIP-Seq_PC3_Human1.05866555
72SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05630848
73TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05279393
74FOXM1_26456572_ChIP-Seq_MCF-7_Human1.03833724
75MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03552341
76NANOG_19829295_ChIP-Seq_ESCs_Human1.02439332
77SOX2_19829295_ChIP-Seq_ESCs_Human1.02439332
78STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.02354480
79TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02171069
80OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02069665
81TBL1_22424771_ChIP-Seq_293T_Human1.01551040
82NCOR_22424771_ChIP-Seq_293T_Human1.01192994
83RNF2_27304074_Chip-Seq_NSC_Mouse1.00607699
84ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99497399
85SMAD_19615063_ChIP-ChIP_OVARY_Human0.98644090
86ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97774405
87OCT1_27270436_Chip-Seq_PROSTATE_Human0.97582913
88VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.96718522
89KDM2B_26808549_Chip-Seq_REH_Human0.96692569
90CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.96003411
91NANOG_18555785_Chip-Seq_ESCs_Mouse0.95690452
92FOXA1_21572438_ChIP-Seq_LNCaP_Human0.95530261
93EZH2_27294783_Chip-Seq_NPCs_Mouse0.94777089
94RXR_22108803_ChIP-Seq_LS180_Human0.94179187
95SMRT_27268052_Chip-Seq_Bcells_Human0.94120759
96CDX2_19796622_ChIP-Seq_MESCs_Mouse0.92868621
97SUZ12_27294783_Chip-Seq_NPCs_Mouse0.92258783
98NFYB_21822215_ChIP-Seq_K562_Human0.91824883
99BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91665822
100CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.91548849

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.77583977
2MP0000569_abnormal_digit_pigmentation3.19085145
3MP0009046_muscle_twitch2.84658918
4MP0002653_abnormal_ependyma_morphology2.75011496
5MP0003136_yellow_coat_color2.49064547
6MP0003646_muscle_fatigue2.30819363
7MP0003195_calcinosis2.30238014
8MP0004043_abnormal_pH_regulation2.27025174
9MP0005551_abnormal_eye_electrophysiolog2.24060743
10MP0001984_abnormal_olfaction2.23356812
11MP0001501_abnormal_sleep_pattern2.07106723
12MP0002735_abnormal_chemical_nociception2.06998294
13MP0008877_abnormal_DNA_methylation1.98257149
14MP0005253_abnormal_eye_physiology1.93715193
15MP0001968_abnormal_touch/_nociception1.91506967
16MP0006276_abnormal_autonomic_nervous1.91322445
17MP0005171_absent_coat_pigmentation1.90320058
18MP0000383_abnormal_hair_follicle1.83492038
19MP0003045_fibrosis1.80308854
20MP0001486_abnormal_startle_reflex1.76387720
21MP0009745_abnormal_behavioral_response1.73713850
22MP0005646_abnormal_pituitary_gland1.66643179
23MP0000427_abnormal_hair_cycle1.55486959
24MP0010094_abnormal_chromosome_stability1.52009885
25MP0003698_abnormal_male_reproductive1.49144350
26MP0002928_abnormal_bile_duct1.48799265
27MP0004147_increased_porphyrin_level1.47115293
28MP0002638_abnormal_pupillary_reflex1.45613505
29MP0002736_abnormal_nociception_after1.45360933
30MP0005410_abnormal_fertilization1.39345403
31MP0005174_abnormal_tail_pigmentation1.38663271
32MP0004142_abnormal_muscle_tone1.37827966
33MP0005645_abnormal_hypothalamus_physiol1.37706623
34MP0006072_abnormal_retinal_apoptosis1.36142783
35MP0002102_abnormal_ear_morphology1.34550093
36MP0000631_abnormal_neuroendocrine_gland1.33905058
37MP0002572_abnormal_emotion/affect_behav1.33368415
38MP0009697_abnormal_copulation1.32243485
39MP0008872_abnormal_physiological_respon1.31997197
40MP0002064_seizures1.31523241
41MP0003635_abnormal_synaptic_transmissio1.30528368
42MP0002168_other_aberrant_phenotype1.29533578
43MP0002272_abnormal_nervous_system1.28022437
44MP0001929_abnormal_gametogenesis1.27247100
45MP0010386_abnormal_urinary_bladder1.26757443
46MP0003787_abnormal_imprinting1.26197589
47MP0004133_heterotaxia1.25355530
48MP0001986_abnormal_taste_sensitivity1.24436114
49MP0002067_abnormal_sensory_capabilities1.23359088
50MP0001485_abnormal_pinna_reflex1.22926863
51MP0000372_irregular_coat_pigmentation1.22312439
52MP0008961_abnormal_basal_metabolism1.21523479
53MP0003890_abnormal_embryonic-extraembry1.19635274
54MP0002822_catalepsy1.17874481
55MP0008875_abnormal_xenobiotic_pharmacok1.17813739
56MP0002837_dystrophic_cardiac_calcinosis1.16689005
57MP0008995_early_reproductive_senescence1.13335414
58MP0002160_abnormal_reproductive_system1.13329233
59MP0002063_abnormal_learning/memory/cond1.11513319
60MP0004924_abnormal_behavior1.10313209
61MP0005386_behavior/neurological_phenoty1.10313209
62MP0003252_abnormal_bile_duct1.08519895
63MP0002095_abnormal_skin_pigmentation1.07938156
64MP0005266_abnormal_metabolism1.07900054
65MP0005310_abnormal_salivary_gland1.06874141
66MP0003878_abnormal_ear_physiology1.05736090
67MP0005377_hearing/vestibular/ear_phenot1.05736090
68MP0001970_abnormal_pain_threshold1.04922855
69MP0004130_abnormal_muscle_cell1.03670485
70MP0004145_abnormal_muscle_electrophysio1.02832449
71MP0002557_abnormal_social/conspecific_i1.01382089
72MP0002229_neurodegeneration0.98841721
73MP0000371_diluted_coat_color0.98191998
74MP0000015_abnormal_ear_pigmentation0.96990882
75MP0005220_abnormal_exocrine_pancreas0.95911707
76MP0004215_abnormal_myocardial_fiber0.95765417
77MP0004859_abnormal_synaptic_plasticity0.95613543
78MP0002396_abnormal_hematopoietic_system0.94305890
79MP0004381_abnormal_hair_follicle0.91542217
80MP0001502_abnormal_circadian_rhythm0.89232956
81MP0005075_abnormal_melanosome_morpholog0.88696315
82MP0002132_abnormal_respiratory_system0.88519772
83MP0005395_other_phenotype0.88050313
84MP0001664_abnormal_digestion0.87510062
85MP0003656_abnormal_erythrocyte_physiolo0.87141611
86MP0002009_preneoplasia0.86985184
87MP0008058_abnormal_DNA_repair0.86432768
88MP0002210_abnormal_sex_determination0.85263740
89MP0001963_abnormal_hearing_physiology0.85250054
90MP0002733_abnormal_thermal_nociception0.85025063
91MP0010678_abnormal_skin_adnexa0.84217125
92MP0004085_abnormal_heartbeat0.80907727
93MP0003137_abnormal_impulse_conducting0.79203659
94MP0002876_abnormal_thyroid_physiology0.78048387
95MP0005195_abnormal_posterior_eye0.76892167
96MP0002734_abnormal_mechanical_nocicepti0.76737895
97MP0003633_abnormal_nervous_system0.76653870
98MP0000653_abnormal_sex_gland0.75839864
99MP0005647_abnormal_sex_gland0.75733694
100MP0004742_abnormal_vestibular_system0.75165325

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)6.47231827
2Absent/shortened dynein arms (HP:0200106)6.47231827
3Abnormal ciliary motility (HP:0012262)5.97843180
4Abnormal respiratory epithelium morphology (HP:0012253)5.79702191
5Abnormal respiratory motile cilium morphology (HP:0005938)5.79702191
6Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.64556124
7Abnormal respiratory motile cilium physiology (HP:0012261)5.53473577
8Rhinitis (HP:0012384)4.62485927
9Genetic anticipation (HP:0003743)4.43172054
10Pancreatic cysts (HP:0001737)4.09559490
11Chronic hepatic failure (HP:0100626)4.09455162
12Pancreatic fibrosis (HP:0100732)3.98564469
13True hermaphroditism (HP:0010459)3.88248714
14Progressive cerebellar ataxia (HP:0002073)3.56199988
15Bronchiectasis (HP:0002110)3.52487446
16Hyperventilation (HP:0002883)3.51602420
17Nephronophthisis (HP:0000090)3.50573512
18Gaze-evoked nystagmus (HP:0000640)3.33390213
19Cystic liver disease (HP:0006706)3.30217398
20Abnormality of midbrain morphology (HP:0002418)3.29384551
21Molar tooth sign on MRI (HP:0002419)3.29384551
22Protruding tongue (HP:0010808)3.20466236
23Attenuation of retinal blood vessels (HP:0007843)3.19715466
24Medial flaring of the eyebrow (HP:0010747)3.12245841
25Abnormality of the renal medulla (HP:0100957)3.06832114
26Tubulointerstitial nephritis (HP:0001970)3.02648529
27Chronic bronchitis (HP:0004469)2.95142219
28Gait imbalance (HP:0002141)2.84332775
29Congenital primary aphakia (HP:0007707)2.82805316
30Bony spicule pigmentary retinopathy (HP:0007737)2.70625989
31Absent speech (HP:0001344)2.65826554
32Febrile seizures (HP:0002373)2.58829416
33Abnormality of the renal cortex (HP:0011035)2.56909521
34Postaxial foot polydactyly (HP:0001830)2.56354170
35Clumsiness (HP:0002312)2.56151179
36Chronic sinusitis (HP:0011109)2.52210377
37Congenital hepatic fibrosis (HP:0002612)2.50868636
38Nephrogenic diabetes insipidus (HP:0009806)2.49195267
39Absent rod-and cone-mediated responses on ERG (HP:0007688)2.48221823
40Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.43845101
41Decreased circulating renin level (HP:0003351)2.41113039
42Central scotoma (HP:0000603)2.34057765
43Occipital encephalocele (HP:0002085)2.33447589
44Poor coordination (HP:0002370)2.29678948
45Nasal polyposis (HP:0100582)2.27617459
46Broad-based gait (HP:0002136)2.26887593
47Recurrent sinusitis (HP:0011108)2.24219080
48Congenital stationary night blindness (HP:0007642)2.23686078
49Tubular atrophy (HP:0000092)2.21019950
50Birth length less than 3rd percentile (HP:0003561)2.18874996
51Genital tract atresia (HP:0001827)2.18110064
52Cerebellar dysplasia (HP:0007033)2.17414079
53Aplasia/Hypoplasia of the tongue (HP:0010295)2.16940762
54Anencephaly (HP:0002323)2.13779186
55Abnormal drinking behavior (HP:0030082)2.13548543
56Polydipsia (HP:0001959)2.13548543
57Abnormal rod and cone electroretinograms (HP:0008323)2.12143932
58Vaginal atresia (HP:0000148)2.08754102
59Bronchitis (HP:0012387)2.06108154
60Focal seizures (HP:0007359)2.06004169
61Aplasia/Hypoplasia of the tibia (HP:0005772)2.05851278
62Dysmetric saccades (HP:0000641)2.04442076
63Increased neuronal autofluorescent lipopigment (HP:0002074)2.04258551
64Abolished electroretinogram (ERG) (HP:0000550)2.01541156
65Sclerocornea (HP:0000647)2.01180590
66Decreased central vision (HP:0007663)2.00045796
67Constricted visual fields (HP:0001133)1.97528758
68Retinitis pigmentosa (HP:0000510)1.96333898
69Chronic otitis media (HP:0000389)1.96170600
70Furrowed tongue (HP:0000221)1.92894225
71Type II lissencephaly (HP:0007260)1.92640340
72Dialeptic seizures (HP:0011146)1.91094641
73Male pseudohermaphroditism (HP:0000037)1.90980481
74Widely spaced teeth (HP:0000687)1.90348474
75Acute lymphatic leukemia (HP:0006721)1.86246715
76Fair hair (HP:0002286)1.86183306
77Infertility (HP:0000789)1.84119907
78Large for gestational age (HP:0001520)1.82297844
79Sloping forehead (HP:0000340)1.81029373
80Short foot (HP:0001773)1.76501920
81Urinary bladder sphincter dysfunction (HP:0002839)1.76452868
82Patellar aplasia (HP:0006443)1.74820147
83Preaxial hand polydactyly (HP:0001177)1.73740390
84Abnormality of macular pigmentation (HP:0008002)1.72912770
85Postaxial hand polydactyly (HP:0001162)1.72094608
86Impaired smooth pursuit (HP:0007772)1.71568602
87Abnormal biliary tract physiology (HP:0012439)1.71507743
88Bile duct proliferation (HP:0001408)1.71507743
89Inability to walk (HP:0002540)1.70984114
90Congenital sensorineural hearing impairment (HP:0008527)1.70827766
91Tubulointerstitial abnormality (HP:0001969)1.70497902
92Oculomotor apraxia (HP:0000657)1.68360925
93Hyperkalemia (HP:0002153)1.68175867
94Highly arched eyebrow (HP:0002553)1.67103921
95Focal motor seizures (HP:0011153)1.66452300
96Astigmatism (HP:0000483)1.62671175
97Absence seizures (HP:0002121)1.61689232
98Small hand (HP:0200055)1.61652661
99Lissencephaly (HP:0001339)1.60502374
100Aplasia/Hypoplasia of the patella (HP:0006498)1.59762168

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK7.97066268
2ACVR1B3.50202497
3BMPR1B2.58527112
4MAPK152.53834597
5INSRR2.50860459
6TAOK32.50064425
7CDK122.47395665
8MAP3K42.37104623
9AKT32.35299945
10ZAK2.05284252
11TLK11.79729058
12MAPK131.78036178
13ADRBK21.72674034
14MAP4K21.69731725
15PINK11.59705168
16STK38L1.56527150
17MAP3K71.43450502
18MKNK21.33204037
19LATS11.31064773
20MAP2K71.30656078
21BRD41.22217242
22NTRK31.21040778
23GRK11.15073776
24OXSR11.13369922
25CAMKK21.10918614
26WNK31.04989182
27NUAK11.04933206
28NLK0.96677704
29CASK0.95676816
30MELK0.90970348
31SGK20.90380914
32EPHA30.89945276
33PLK40.89425062
34TEC0.89371286
35CSNK1A1L0.89040436
36SIK20.87619085
37PTK2B0.86461349
38DAPK20.85735976
39PRKAA20.85572651
40CAMK1G0.85355150
41BLK0.85204014
42RPS6KA50.82295611
43BRSK20.82068749
44FLT30.80013156
45OBSCN0.79302853
46ADRBK10.76069816
47PIK3CG0.75767944
48PRKAA10.75255473
49NEK20.74782864
50WNK10.72893265
51STK380.71866469
52MARK10.70109541
53TNK20.67800668
54TRPM70.66959774
55ATR0.64549565
56BTK0.64011452
57CDK190.63928864
58PKN10.63632645
59MAPK110.61533857
60BCR0.61516541
61EPHA40.60844160
62MKNK10.60517391
63MARK20.59711575
64CAMK40.58968976
65CHEK20.57484989
66KIT0.57290141
67CAMKK10.56330349
68CAMK10.56078236
69MAP2K40.55818667
70SGK4940.53866876
71SGK2230.53866876
72CAMK1D0.53591567
73IRAK10.53187732
74WNK40.52934390
75MARK30.52883910
76TGFBR10.52371893
77STK110.49847243
78CCNB10.49665549
79SYK0.49653112
80PNCK0.48231192
81STK390.47525503
82ATM0.46770168
83DYRK1A0.45372443
84ERBB20.44217939
85PRKCE0.43758860
86CAMK2A0.42993742
87PRKCQ0.41651503
88CSNK1G20.41021742
89SGK10.38674238
90TXK0.36957543
91CSNK1G10.36552777
92PLK10.35828138
93PAK30.35774466
94PDK10.35137929
95CDC70.34765128
96GSK3B0.34263773
97CSNK1D0.34081038
98CHUK0.33930819
99CSNK1G30.32169300
100HIPK20.31690811

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.76881169
2Homologous recombination_Homo sapiens_hsa034402.60790273
3ABC transporters_Homo sapiens_hsa020102.51064433
4Taste transduction_Homo sapiens_hsa047422.45446346
5Phototransduction_Homo sapiens_hsa047442.40800139
6Fanconi anemia pathway_Homo sapiens_hsa034602.38352238
7Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.31331811
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.22735283
9Linoleic acid metabolism_Homo sapiens_hsa005912.08056132
10Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.03223200
11Butanoate metabolism_Homo sapiens_hsa006502.02700501
12Olfactory transduction_Homo sapiens_hsa047401.91394386
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.83684703
14Morphine addiction_Homo sapiens_hsa050321.73939014
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.69691477
16Circadian entrainment_Homo sapiens_hsa047131.62984046
17Circadian rhythm_Homo sapiens_hsa047101.58360428
18Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.56944309
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.56770371
20Dorso-ventral axis formation_Homo sapiens_hsa043201.53539760
21Calcium signaling pathway_Homo sapiens_hsa040201.49893294
22Salivary secretion_Homo sapiens_hsa049701.49356545
23Ether lipid metabolism_Homo sapiens_hsa005651.48388657
24GABAergic synapse_Homo sapiens_hsa047271.45251625
25Glutamatergic synapse_Homo sapiens_hsa047241.42363614
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.41447449
27Lysine degradation_Homo sapiens_hsa003101.36791126
28Tryptophan metabolism_Homo sapiens_hsa003801.34989069
29Nitrogen metabolism_Homo sapiens_hsa009101.20756408
30Serotonergic synapse_Homo sapiens_hsa047261.19515678
31Alcoholism_Homo sapiens_hsa050341.15501206
32Non-homologous end-joining_Homo sapiens_hsa034501.13460790
33Pancreatic secretion_Homo sapiens_hsa049721.11988002
34Selenocompound metabolism_Homo sapiens_hsa004501.10155047
35Systemic lupus erythematosus_Homo sapiens_hsa053221.09980589
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.09587818
37Steroid hormone biosynthesis_Homo sapiens_hsa001401.07801911
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.06249016
39Insulin secretion_Homo sapiens_hsa049111.06033661
40Cholinergic synapse_Homo sapiens_hsa047251.05287965
41Glycerolipid metabolism_Homo sapiens_hsa005611.00694886
42Type II diabetes mellitus_Homo sapiens_hsa049300.98763536
43Chemical carcinogenesis_Homo sapiens_hsa052040.98015095
44Phosphatidylinositol signaling system_Homo sapiens_hsa040700.97356480
45Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.92912353
46beta-Alanine metabolism_Homo sapiens_hsa004100.92342914
47Ovarian steroidogenesis_Homo sapiens_hsa049130.91992753
48Vascular smooth muscle contraction_Homo sapiens_hsa042700.90371114
49Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88247135
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.87118004
51cAMP signaling pathway_Homo sapiens_hsa040240.85913345
52Oxytocin signaling pathway_Homo sapiens_hsa049210.84097367
53Primary bile acid biosynthesis_Homo sapiens_hsa001200.82401403
54Transcriptional misregulation in cancer_Homo sapiens_hsa052020.81830952
55Histidine metabolism_Homo sapiens_hsa003400.81322831
56Maturity onset diabetes of the young_Homo sapiens_hsa049500.78539690
57Basal transcription factors_Homo sapiens_hsa030220.78447721
58Regulation of autophagy_Homo sapiens_hsa041400.76543463
59Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.75989004
60Renin secretion_Homo sapiens_hsa049240.75882205
61Glycerophospholipid metabolism_Homo sapiens_hsa005640.73770408
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.72902118
63Aldosterone synthesis and secretion_Homo sapiens_hsa049250.72273166
64Gastric acid secretion_Homo sapiens_hsa049710.72219129
65Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.71924696
66Intestinal immune network for IgA production_Homo sapiens_hsa046720.68307844
67Dopaminergic synapse_Homo sapiens_hsa047280.66552187
68cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66050445
69Retinol metabolism_Homo sapiens_hsa008300.65797844
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65136780
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.63977310
72Arachidonic acid metabolism_Homo sapiens_hsa005900.63481167
73Amphetamine addiction_Homo sapiens_hsa050310.62456154
74Fatty acid biosynthesis_Homo sapiens_hsa000610.62341074
75Purine metabolism_Homo sapiens_hsa002300.60859802
76Long-term depression_Homo sapiens_hsa047300.60617739
77Choline metabolism in cancer_Homo sapiens_hsa052310.59837415
78Cocaine addiction_Homo sapiens_hsa050300.58963920
79Base excision repair_Homo sapiens_hsa034100.57823766
80Mismatch repair_Homo sapiens_hsa034300.57573800
81Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56467198
82Sphingolipid metabolism_Homo sapiens_hsa006000.54929227
83Inositol phosphate metabolism_Homo sapiens_hsa005620.51236098
84Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.50926753
85FoxO signaling pathway_Homo sapiens_hsa040680.46642428
86Peroxisome_Homo sapiens_hsa041460.45301210
87Primary immunodeficiency_Homo sapiens_hsa053400.43635311
88Platelet activation_Homo sapiens_hsa046110.41484175
89Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.41185896
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40099078
91Jak-STAT signaling pathway_Homo sapiens_hsa046300.39839527
92Cell cycle_Homo sapiens_hsa041100.36417028
93RNA polymerase_Homo sapiens_hsa030200.36157912
94Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.35843712
95Oocyte meiosis_Homo sapiens_hsa041140.35434220
96Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.33718651
97Propanoate metabolism_Homo sapiens_hsa006400.32409853
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30772522
99MAPK signaling pathway_Homo sapiens_hsa040100.30528234
100NOD-like receptor signaling pathway_Homo sapiens_hsa046210.28495411

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