DPY19L4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1paraxial mesoderm development (GO:0048339)3.66621108
2embryonic foregut morphogenesis (GO:0048617)3.53265913
3cytoplasmic mRNA processing body assembly (GO:0033962)3.40126180
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.12924992
5cell adhesion mediated by integrin (GO:0033627)3.05696569
6mitotic sister chromatid cohesion (GO:0007064)3.01617410
7notochord development (GO:0030903)2.98665415
8prostate gland growth (GO:0060736)2.93297069
9regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.91499304
10insulin-like growth factor receptor signaling pathway (GO:0048009)2.86115430
11artery development (GO:0060840)2.82442834
12regulation of interferon-beta biosynthetic process (GO:0045357)2.82259682
13regulation of centriole replication (GO:0046599)2.81052251
14I-kappaB phosphorylation (GO:0007252)2.75408901
15axon extension involved in axon guidance (GO:0048846)2.70054453
16neuron projection extension involved in neuron projection guidance (GO:1902284)2.70054453
17regulation of cardioblast differentiation (GO:0051890)2.66178247
18hippo signaling (GO:0035329)2.63297000
19nuclear pore organization (GO:0006999)2.60331482
20negative regulation of DNA repair (GO:0045738)2.58379569
21desmosome organization (GO:0002934)2.51069810
22negative regulation of axon extension involved in axon guidance (GO:0048843)2.50644595
23nuclear pore complex assembly (GO:0051292)2.50218249
24substrate-dependent cell migration (GO:0006929)2.49556379
25positive regulation of cardiac muscle cell differentiation (GO:2000727)2.47360768
26prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.46552634
27regulation of centrosome duplication (GO:0010824)2.45060434
28negative regulation of vascular permeability (GO:0043116)2.44352704
29interkinetic nuclear migration (GO:0022027)2.43782116
30retina vasculature morphogenesis in camera-type eye (GO:0061299)2.43346472
31import into cell (GO:0098657)2.43138129
32cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.42932627
33lymphangiogenesis (GO:0001946)2.42399572
34DNA double-strand break processing (GO:0000729)2.41829829
35positive regulation by symbiont of host defense response (GO:0052509)2.41279169
36modulation by symbiont of host defense response (GO:0052031)2.41279169
37modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.41279169
38modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.41279169
39positive regulation by organism of defense response of other organism involved in symbiotic interact2.41279169
40modulation by symbiont of host immune response (GO:0052553)2.41279169
41bundle of His cell to Purkinje myocyte communication (GO:0086069)2.41152165
42face morphogenesis (GO:0060325)2.39486846
43positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.39305624
44gland morphogenesis (GO:0022612)2.39231105
45germ cell migration (GO:0008354)2.39080241
46response to cholesterol (GO:0070723)2.37147510
47regulation of hippo signaling (GO:0035330)2.36956731
48regulation of transforming growth factor beta2 production (GO:0032909)2.34975192
49regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.34350337
50response to follicle-stimulating hormone (GO:0032354)2.32065551
51collagen fibril organization (GO:0030199)2.31709531
52NLS-bearing protein import into nucleus (GO:0006607)2.31146249
53somatic stem cell division (GO:0048103)2.30897549
54gap junction assembly (GO:0016264)2.29007115
55negative regulation of translation, ncRNA-mediated (GO:0040033)2.28778149
56regulation of translation, ncRNA-mediated (GO:0045974)2.28778149
57negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.28778149
58protein prenylation (GO:0018342)2.28708655
59prenylation (GO:0097354)2.28708655
60apoptotic cell clearance (GO:0043277)2.28285796
61growth hormone receptor signaling pathway (GO:0060396)2.27810109
62microglial cell activation (GO:0001774)2.27756122
63negative regulation of keratinocyte proliferation (GO:0010839)2.27335989
64metanephric mesenchyme development (GO:0072075)2.25447916
65regulation of male gonad development (GO:2000018)2.25294188
66regulation of centrosome cycle (GO:0046605)2.25201060
67iron ion import (GO:0097286)2.24471940
68branching involved in prostate gland morphogenesis (GO:0060442)2.23465814
69establishment of protein localization to Golgi (GO:0072600)2.22553937
70response to lipoprotein particle (GO:0055094)2.22124606
71retrograde transport, vesicle recycling within Golgi (GO:0000301)2.21900859
72sister chromatid segregation (GO:0000819)2.21565634
73anterior/posterior axis specification, embryo (GO:0008595)2.21128715
74smooth muscle tissue development (GO:0048745)2.20559605
75positive regulation of male gonad development (GO:2000020)2.19841292
76regulation of keratinocyte proliferation (GO:0010837)2.18925458
77genitalia morphogenesis (GO:0035112)2.18515654
78negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.18178382
79morphogenesis of an epithelial sheet (GO:0002011)2.17859312
80dorsal/ventral axis specification (GO:0009950)2.17605733
81protein targeting to Golgi (GO:0000042)2.17143089
82platelet-derived growth factor receptor signaling pathway (GO:0048008)2.16693930
83mesenchymal-epithelial cell signaling (GO:0060638)2.16048401
84coronary vasculature morphogenesis (GO:0060977)2.15494459
85regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.15139901
86regulation of axon extension involved in axon guidance (GO:0048841)2.14464992
87anatomical structure arrangement (GO:0048532)2.14285559
88kidney mesenchyme development (GO:0072074)2.14135159
89ventricular cardiac muscle cell development (GO:0055015)2.13407754
90nucleus localization (GO:0051647)2.13230874
91response to sterol (GO:0036314)2.12113116
92mesenchymal cell differentiation (GO:0048762)2.11937425
93positive regulation of cardiac muscle hypertrophy (GO:0010613)2.11863503
94positive regulation of muscle hypertrophy (GO:0014742)2.11863503
95negative regulation of axon guidance (GO:1902668)2.11828923
96radial glial cell differentiation (GO:0060019)2.11307578
97pericardium development (GO:0060039)2.11260342
98dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.11011540
99positive regulation of protein autophosphorylation (GO:0031954)2.10901201
100regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.10016394
101positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.10016394
102regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.09671011
103positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.09057299
104positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.09057299
105positive regulation of mitotic sister chromatid separation (GO:1901970)2.09057299
106cellular potassium ion homeostasis (GO:0030007)2.08934686
107craniofacial suture morphogenesis (GO:0097094)2.08901582
108lateral sprouting from an epithelium (GO:0060601)2.08494191
109positive regulation of mesenchymal cell proliferation (GO:0002053)2.08307598
110protein localization to cell surface (GO:0034394)2.08131160
111dendrite morphogenesis (GO:0048813)2.07757891
112regulation of axon guidance (GO:1902667)2.07424843
113positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.07090948
114regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.07090948
115establishment of nucleus localization (GO:0040023)2.06711138
116UDP-N-acetylglucosamine metabolic process (GO:0006047)2.06572105
117embryonic cranial skeleton morphogenesis (GO:0048701)2.06033868
118pathway-restricted SMAD protein phosphorylation (GO:0060389)2.05867920
119regulation of DNA endoreduplication (GO:0032875)2.05387193
120chondrocyte development (GO:0002063)2.05378031
121regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.05267022
122positive regulation of catenin import into nucleus (GO:0035413)2.04824266
123regulation of clathrin-mediated endocytosis (GO:2000369)2.04648644
124camera-type eye morphogenesis (GO:0048593)2.04643721
125outer ear morphogenesis (GO:0042473)2.04522831
126Leydig cell differentiation (GO:0033327)2.04130668
127negative regulation of neurotransmitter secretion (GO:0046929)2.02652678
128semaphorin-plexin signaling pathway (GO:0071526)2.02475796
129sarcomere organization (GO:0045214)2.02314286
130polarized epithelial cell differentiation (GO:0030859)2.01758405
131protein localization to endosome (GO:0036010)2.01475398
132cardiac right ventricle morphogenesis (GO:0003215)2.01470456
133embryonic viscerocranium morphogenesis (GO:0048703)2.00964086
134negative regulation of systemic arterial blood pressure (GO:0003085)2.00413430
135clathrin coat assembly (GO:0048268)1.99895642
136negative regulation of osteoclast differentiation (GO:0045671)1.99130936
137mesodermal cell differentiation (GO:0048333)1.98635247
138cellular response to vitamin (GO:0071295)1.98405489
139peptidyl-threonine modification (GO:0018210)1.98237751
140cellular response to interferon-alpha (GO:0035457)1.98227904
141cardiac myofibril assembly (GO:0055003)1.97713726
142regulation of mesenchymal cell proliferation (GO:0010464)1.97560481
143ganglion development (GO:0061548)1.97224914
144regulation of attachment of spindle microtubules to kinetochore (GO:0051988)1.97024628
145resolution of meiotic recombination intermediates (GO:0000712)1.96793917
146myelination in peripheral nervous system (GO:0022011)1.96753494
147peripheral nervous system axon ensheathment (GO:0032292)1.96753494
148embryonic retina morphogenesis in camera-type eye (GO:0060059)1.96711077
149cellular response to growth hormone stimulus (GO:0071378)1.96660145
150cellular response to cholesterol (GO:0071397)1.96461435
151metaphase plate congression (GO:0051310)1.96220593
152mitotic sister chromatid segregation (GO:0000070)1.95992698
153COPII vesicle coating (GO:0048208)1.95562633
154embryonic heart tube development (GO:0035050)1.95504099
155regulation of non-canonical Wnt signaling pathway (GO:2000050)1.95488990
156regulation of Rac protein signal transduction (GO:0035020)1.94905950
157sequestering of extracellular ligand from receptor (GO:0035581)1.94833855
158negative regulation of chondrocyte differentiation (GO:0032331)1.94705466
159positive regulation of osteoblast proliferation (GO:0033690)1.94604871
160regulation of cell proliferation involved in heart morphogenesis (GO:2000136)1.94468965
161regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)1.93298750
162regulation of sister chromatid cohesion (GO:0007063)1.92930201
163cellular response to vitamin D (GO:0071305)1.92121863
164regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)1.91836917
165negative regulation of cytosolic calcium ion concentration (GO:0051481)1.90151177
166vascular smooth muscle contraction (GO:0014829)1.89483797
167gastrulation with mouth forming second (GO:0001702)1.88945575
168histone-serine phosphorylation (GO:0035404)1.87350307
169limb bud formation (GO:0060174)1.86909206
170negative regulation of striated muscle cell apoptotic process (GO:0010664)1.86908931
171negative regulation of hormone biosynthetic process (GO:0032353)1.86535340
172regulation of hexokinase activity (GO:1903299)1.86411418
173regulation of glucokinase activity (GO:0033131)1.86411418
174regulation of heart morphogenesis (GO:2000826)1.86147857
175neural crest cell development (GO:0014032)1.85527650
176establishment of apical/basal cell polarity (GO:0035089)1.85229980
177replication fork processing (GO:0031297)1.85069761
178cellular response to sterol (GO:0036315)1.84624615
179male genitalia development (GO:0030539)1.83788805
180regulation of nephron tubule epithelial cell differentiation (GO:0072182)1.83717641

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.72744513
2AR_21909140_ChIP-Seq_LNCAP_Human2.34965352
3SALL1_21062744_ChIP-ChIP_HESCs_Human2.31689788
4RBPJ_22232070_ChIP-Seq_NCS_Mouse2.27594328
5TP53_16413492_ChIP-PET_HCT116_Human2.27309032
6SMAD_19615063_ChIP-ChIP_OVARY_Human2.22270289
7ZNF217_24962896_ChIP-Seq_MCF-7_Human2.10070375
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.05199101
9CDX2_19796622_ChIP-Seq_MESCs_Mouse2.03906552
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.02476910
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.00613997
12GBX2_23144817_ChIP-Seq_PC3_Human2.00498100
13WT1_19549856_ChIP-ChIP_CCG9911_Human1.94132848
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.92616336
15ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.92612033
16AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.82074567
17KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.81980807
18AR_21572438_ChIP-Seq_LNCaP_Human1.80576356
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.76945074
20POU3F2_20337985_ChIP-ChIP_501MEL_Human1.75587385
21PIAS1_25552417_ChIP-Seq_VCAP_Human1.74349473
22ER_23166858_ChIP-Seq_MCF-7_Human1.70357160
23TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.69223410
24ELK1_19687146_ChIP-ChIP_HELA_Human1.68760083
25VDR_22108803_ChIP-Seq_LS180_Human1.65780755
26PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.65284198
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.63275391
28SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.59950690
29FLI1_27457419_Chip-Seq_LIVER_Mouse1.59883816
30CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.52499646
31GATA1_22025678_ChIP-Seq_K562_Human1.52179668
32RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.51644827
33TP53_18474530_ChIP-ChIP_U2OS_Human1.50067303
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.49681291
35AHR_22903824_ChIP-Seq_MCF-7_Human1.47020477
36SMAD4_21799915_ChIP-Seq_A2780_Human1.46905553
37EP300_21415370_ChIP-Seq_HL-1_Mouse1.46856355
38TRIM28_21343339_ChIP-Seq_HEK293_Human1.46854993
39TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.46837200
40Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.44302426
41CJUN_26792858_Chip-Seq_BT549_Human1.44242883
42E2F7_22180533_ChIP-Seq_HELA_Human1.42800702
43ESR1_20079471_ChIP-ChIP_T-47D_Human1.42236064
44NRF2_20460467_ChIP-Seq_MEFs_Mouse1.40948619
45NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.40948619
46* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.39330672
47ARNT_22903824_ChIP-Seq_MCF-7_Human1.38432521
48HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.35753125
49ZNF274_21170338_ChIP-Seq_K562_Hela1.35069773
50STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.34193248
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.33287673
52OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32573551
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.31938281
54SALL4_18804426_ChIP-ChIP_XEN_Mouse1.31680458
55HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.30847657
56PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.30373474
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28173519
58STAT3_23295773_ChIP-Seq_U87_Human1.27633278
59RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27577023
60BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.26793821
61SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.26147187
62RXR_22108803_ChIP-Seq_LS180_Human1.26082863
63P300_19829295_ChIP-Seq_ESCs_Human1.25974473
64BRD4_25478319_ChIP-Seq_HGPS_Human1.25549089
65SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24492858
66PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23531923
67WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.23150566
68FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.22118900
69IGF1R_20145208_ChIP-Seq_DFB_Human1.21977712
70RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.21696047
71FOXM1_26456572_ChIP-Seq_MCF-7_Human1.21539383
72EZH2_27294783_Chip-Seq_NPCs_Mouse1.21450329
73CTBP1_25329375_ChIP-Seq_LNCAP_Human1.20174750
74PADI4_21655091_ChIP-ChIP_MCF-7_Human1.19815832
75STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.19648468
76EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.19358043
77EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.19035950
78CTNNB1_20460455_ChIP-Seq_HCT116_Human1.18679986
79E2F4_17652178_ChIP-ChIP_JURKAT_Human1.18631889
80BCAT_22108803_ChIP-Seq_LS180_Human1.18562801
81FOXO3_23340844_ChIP-Seq_DLD1_Human1.18415641
82NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18398397
83RNF2_18974828_ChIP-Seq_MESCs_Mouse1.18000637
84EZH2_18974828_ChIP-Seq_MESCs_Mouse1.18000637
85TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17436041
86SOX2_21211035_ChIP-Seq_LN229_Gbm1.16940672
87PPAR_26484153_Chip-Seq_NCI-H1993_Human1.16607843
88TCF4_18268006_ChIP-ChIP_LS174T_Human1.16536568
89ISL1_27105846_Chip-Seq_CPCs_Mouse1.16491978
90CDX2_22108803_ChIP-Seq_LS180_Human1.15665888
91STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.15503274
92EGR1_19374776_ChIP-ChIP_THP-1_Human1.14507065
93SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.14150847
94SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.13777705
95SOX9_24532713_ChIP-Seq_HFSC_Mouse1.13083270
96WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13021527
97UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12942780
98E2F1_18555785_Chip-Seq_ESCs_Mouse1.12822442
99VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.11157308
100JARID2_20064375_ChIP-Seq_MESCs_Mouse1.10806857
101SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.10620771
102TAF15_26573619_Chip-Seq_HEK293_Human1.10499204
103NANOG_18555785_Chip-Seq_ESCs_Mouse1.09630452
104FUS_26573619_Chip-Seq_HEK293_Human1.09536411
105EED_16625203_ChIP-ChIP_MESCs_Mouse1.09384985
106* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09240055
107MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09022481
108ZFP57_27257070_Chip-Seq_ESCs_Mouse1.08884197
109TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.08240033
110SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.08154099
111SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.07690687
112ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07682461
113* AR_25329375_ChIP-Seq_VCAP_Human1.07434748
114TCF4_23295773_ChIP-Seq_U87_Human1.06946863
115P53_22387025_ChIP-Seq_ESCs_Mouse1.06490226
116DROSHA_22980978_ChIP-Seq_HELA_Human1.06438284
117CMYC_18555785_Chip-Seq_ESCs_Mouse1.06172569
118TBX3_20139965_ChIP-Seq_MESCs_Mouse1.06105124
119TBX3_20139965_ChIP-Seq_ESCs_Mouse1.05578333
120* MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.05170405
121FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04885306
122NR3C1_23031785_ChIP-Seq_PC12_Mouse1.04696704
123YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04548106
124EWS_26573619_Chip-Seq_HEK293_Human1.04179063
125RUNX2_22187159_ChIP-Seq_PCA_Human1.03877675
126DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.03450687
127IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.01963562
128CBP_20019798_ChIP-Seq_JUKART_Human1.01963562
129TCF4_22108803_ChIP-Seq_LS180_Human1.01914400
130TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.01732875
131IRF8_27001747_Chip-Seq_BMDM_Mouse1.00709062
132TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00580283
133SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00334481
134SMAD3_21741376_ChIP-Seq_HESCs_Human1.00239552
135* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.00070702
136VDR_24787735_ChIP-Seq_THP-1_Human1.00034130
137CLOCK_20551151_ChIP-Seq_293T_Human0.98991864
138GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98563129
139MTF2_20144788_ChIP-Seq_MESCs_Mouse0.98495712
140SUZ12_18555785_Chip-Seq_ESCs_Mouse0.96916610
141KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.96711911
142CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.96239591
143P300_18555785_Chip-Seq_ESCs_Mouse0.96055604
144PCGF2_27294783_Chip-Seq_NPCs_Mouse0.95745901
145KLF5_20875108_ChIP-Seq_MESCs_Mouse0.95546417

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.36591130
2MP0008438_abnormal_cutaneous_collagen3.87320272
3MP0003300_gastrointestinal_ulcer3.02066943
4MP0004272_abnormal_basement_membrane2.70110635
5MP0010234_abnormal_vibrissa_follicle2.68556368
6MP0005503_abnormal_tendon_morphology2.58461876
7MP0001299_abnormal_eye_distance/2.51163259
8MP0003045_fibrosis2.38337923
9MP0003705_abnormal_hypodermis_morpholog2.33670512
10MP0010678_abnormal_skin_adnexa2.32162558
11MP0009697_abnormal_copulation2.24398016
12MP0003941_abnormal_skin_development2.22550811
13MP0005171_absent_coat_pigmentation2.17702026
14MP0004084_abnormal_cardiac_muscle2.16802595
15MP0000566_synostosis2.16424127
16MP0000733_abnormal_muscle_development2.11188064
17MP0005248_abnormal_Harderian_gland2.05516577
18MP0009780_abnormal_chondrocyte_physiolo2.04612967
19MP0009384_cardiac_valve_regurgitation1.98980800
20MP0010368_abnormal_lymphatic_system1.93486011
21MP0005275_abnormal_skin_tensile1.91351376
22MP0003690_abnormal_glial_cell1.82428606
23MP0005623_abnormal_meninges_morphology1.79083089
24MP0005076_abnormal_cell_differentiation1.78985261
25MP0005257_abnormal_intraocular_pressure1.74370503
26MP0000383_abnormal_hair_follicle1.74174405
27MP0004215_abnormal_myocardial_fiber1.71515077
28MP0000428_abnormal_craniofacial_morphol1.68350099
29MP0002896_abnormal_bone_mineralization1.63599096
30MP0002168_other_aberrant_phenotype1.63295002
31MP0001661_extended_life_span1.63167378
32MP0002877_abnormal_melanocyte_morpholog1.60170743
33MP0001346_abnormal_lacrimal_gland1.60065161
34MP0003385_abnormal_body_wall1.58089840
35MP0009250_abnormal_appendicular_skeleto1.57887784
36MP0003787_abnormal_imprinting1.56969888
37MP0003566_abnormal_cell_adhesion1.50005583
38MP0002102_abnormal_ear_morphology1.49450306
39MP0003937_abnormal_limbs/digits/tail_de1.48416388
40MP0006054_spinal_hemorrhage1.45700406
41MP0003091_abnormal_cell_migration1.44450665
42MP0002009_preneoplasia1.43164932
43MP0001958_emphysema1.40881964
44MP0005187_abnormal_penis_morphology1.38050711
45MP0003283_abnormal_digestive_organ1.34800537
46MP0004885_abnormal_endolymph1.34153410
47MP0003942_abnormal_urinary_system1.33209599
48MP0000462_abnormal_digestive_system1.32018282
49MP0002837_dystrophic_cardiac_calcinosis1.31968939
50MP0003950_abnormal_plasma_membrane1.31598661
51MP0004134_abnormal_chest_morphology1.30977197
52MP0004185_abnormal_adipocyte_glucose1.29519857
53MP0001293_anophthalmia1.26854450
54MP0003195_calcinosis1.26776564
55MP0010352_gastrointestinal_tract_polyps1.26633170
56MP0005197_abnormal_uvea_morphology1.25909254
57MP0003935_abnormal_craniofacial_develop1.24938972
58MP0001177_atelectasis1.24286041
59MP0000427_abnormal_hair_cycle1.23812136
60MP0000534_abnormal_ureter_morphology1.23553264
61MP0000762_abnormal_tongue_morphology1.23133972
62MP0008775_abnormal_heart_ventricle1.22958850
63MP0002938_white_spotting1.22802323
64MP0003279_aneurysm1.22649516
65MP0002108_abnormal_muscle_morphology1.19197500
66MP0000013_abnormal_adipose_tissue1.18800733
67MP0010030_abnormal_orbit_morphology1.18313254
68MP0000432_abnormal_head_morphology1.18161524
69MP0005058_abnormal_lysosome_morphology1.17243349
70MP0009053_abnormal_anal_canal1.16640039
71MP0002160_abnormal_reproductive_system1.16153795
72MP0003121_genomic_imprinting1.16045153
73MP0000003_abnormal_adipose_tissue1.13829843
74MP0002233_abnormal_nose_morphology1.12218186
75MP0002928_abnormal_bile_duct1.12167492
76MP0005508_abnormal_skeleton_morphology1.11989755
77MP0002115_abnormal_skeleton_extremities1.11395505
78MP0002166_altered_tumor_susceptibility1.11096730
79MP0001915_intracranial_hemorrhage1.11042603
80MP0003755_abnormal_palate_morphology1.10207831
81MP0002925_abnormal_cardiovascular_devel1.09866838
82MP0003303_peritoneal_inflammation1.09393707
83MP0002084_abnormal_developmental_patter1.08136846
84MP0003136_yellow_coat_color1.07996937
85MP0004036_abnormal_muscle_relaxation1.06358352
86MP0006072_abnormal_retinal_apoptosis1.05495504
87MP0000371_diluted_coat_color1.05338157
88MP0006138_congestive_heart_failure1.04400923
89MP0005408_hypopigmentation1.04113478
90MP0003122_maternal_imprinting1.03843633
91MP0001879_abnormal_lymphatic_vessel1.02758074
92MP0001286_abnormal_eye_development1.00099364
93MP0005666_abnormal_adipose_tissue1.00058631
94MP0002090_abnormal_vision0.99590508
95MP0003315_abnormal_perineum_morphology0.99374118
96MP0002092_abnormal_eye_morphology0.98876660
97MP0003119_abnormal_digestive_system0.98669412
98MP0000647_abnormal_sebaceous_gland0.97724186
99MP0003828_pulmonary_edema0.97129660
100MP0002254_reproductive_system_inflammat0.97094835
101MP0008877_abnormal_DNA_methylation0.96629716
102MP0000749_muscle_degeneration0.95792493
103MP0000767_abnormal_smooth_muscle0.95558286
104MP0002234_abnormal_pharynx_morphology0.95329745
105MP0004233_abnormal_muscle_weight0.95270797
106MP0000751_myopathy0.94495728
107MP0010307_abnormal_tumor_latency0.94275060
108MP0002006_tumorigenesis0.93673951
109MP0002269_muscular_atrophy0.93499594
110MP0002998_abnormal_bone_remodeling0.92799847
111MP0005367_renal/urinary_system_phenotyp0.91932295
112MP0000516_abnormal_urinary_system0.91932295
113MP0002295_abnormal_pulmonary_circulatio0.90129211
114MP0002060_abnormal_skin_morphology0.89737115
115MP0003252_abnormal_bile_duct0.89627097
116MP0002697_abnormal_eye_size0.89543959
117MP0002109_abnormal_limb_morphology0.89465860
118MP0001324_abnormal_eye_pigmentation0.88657906
119MP0000372_irregular_coat_pigmentation0.88452660
120MP0000163_abnormal_cartilage_morphology0.87687201
121MP0002177_abnormal_outer_ear0.87081160
122MP0004197_abnormal_fetal_growth/weight/0.86002575
123MP0008057_abnormal_DNA_replication0.85559305
124MP0000537_abnormal_urethra_morphology0.84836547
125MP0003172_abnormal_lysosome_physiology0.84829801
126MP0010094_abnormal_chromosome_stability0.84619918
127MP0002282_abnormal_trachea_morphology0.84490479
128MP0003890_abnormal_embryonic-extraembry0.84452366
129MP0003984_embryonic_growth_retardation0.83444413
130MP0002098_abnormal_vibrissa_morphology0.83262042
131MP0004130_abnormal_muscle_cell0.83118476
132MP0002088_abnormal_embryonic_growth/wei0.82639745
133MP0002133_abnormal_respiratory_system0.82498268
134MP0005388_respiratory_system_phenotype0.82498268
135MP0005380_embryogenesis_phenotype0.81830171
136MP0001672_abnormal_embryogenesis/_devel0.81830171
137MP0002085_abnormal_embryonic_tissue0.81496363
138MP0002113_abnormal_skeleton_development0.81104244
139MP0002111_abnormal_tail_morphology0.79837443
140MP0005375_adipose_tissue_phenotype0.78457474
141MP0001270_distended_abdomen0.78274120
142MP0001340_abnormal_eyelid_morphology0.78188667
143MP0003943_abnormal_hepatobiliary_system0.77772045
144MP0002128_abnormal_blood_circulation0.77668686
145MP0005391_vision/eye_phenotype0.77153640
146MP0002249_abnormal_larynx_morphology0.75936880
147MP0003868_abnormal_feces_composition0.75184675
148MP0003936_abnormal_reproductive_system0.75092767
149MP0004957_abnormal_blastocyst_morpholog0.75057560
150MP0001614_abnormal_blood_vessel0.74871671
151MP0005620_abnormal_muscle_contractility0.74762044
152MP0005330_cardiomyopathy0.73787447
153MP0001851_eye_inflammation0.73159950
154MP0003115_abnormal_respiratory_system0.70870305
155MP0001697_abnormal_embryo_size0.70335811
156MP0009703_decreased_birth_body0.70085658

Predicted human phenotypes

RankGene SetZ-score
1Shallow orbits (HP:0000586)3.77697556
2Arterial tortuosity (HP:0005116)3.72318900
3Vascular tortuosity (HP:0004948)3.57658800
4Cerebral aneurysm (HP:0004944)3.34899271
5Hematochezia (HP:0002573)3.33008925
6Short 4th metacarpal (HP:0010044)3.29885685
7Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.29885685
8Abnormality of the nasal septum (HP:0000419)3.25096948
9Broad ribs (HP:0000885)3.16941585
10Aortic aneurysm (HP:0004942)3.08142659
11Macroorchidism (HP:0000053)2.69936300
12Aortic dissection (HP:0002647)2.59140926
13Right ventricular cardiomyopathy (HP:0011663)2.55512764
14Increased density of long bones (HP:0006392)2.52439071
15Abnormality of the 4th metacarpal (HP:0010012)2.49563805
16Aqueductal stenosis (HP:0002410)2.49267336
17Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.49006153
18Hypoplastic labia majora (HP:0000059)2.48570753
19Abnormality of the ischium (HP:0003174)2.44070691
20Spinal cord lesions (HP:0100561)2.38464092
21Syringomyelia (HP:0003396)2.38464092
22Narrow palate (HP:0000189)2.32259374
23Chromsome breakage (HP:0040012)2.27926881
24Mitral valve prolapse (HP:0001634)2.25341375
25Abnormality of the right ventricle (HP:0001707)2.21319340
26Abnormality of the labia majora (HP:0012881)2.20907795
27Premature rupture of membranes (HP:0001788)2.20884039
28Volvulus (HP:0002580)2.12503424
29Chromosomal breakage induced by crosslinking agents (HP:0003221)2.09816388
30Hypoplastic nipples (HP:0002557)2.06410921
31Tibial bowing (HP:0002982)2.05217709
32Urethral obstruction (HP:0000796)2.04776815
33Aneurysm (HP:0002617)2.03734135
34Enlarged penis (HP:0000040)2.03554074
35Aplasia involving bones of the upper limbs (HP:0009823)2.03083303
36Aplasia of the phalanges of the hand (HP:0009802)2.03083303
37Aplasia involving bones of the extremities (HP:0009825)2.03083303
38Spondylolisthesis (HP:0003302)2.01074471
39Proximal tubulopathy (HP:0000114)2.00907499
40Broad metatarsal (HP:0001783)2.00123254
41Subacute progressive viral hepatitis (HP:0006572)1.99976595
42Bladder neoplasm (HP:0009725)1.97688277
43Bladder carcinoma (HP:0002862)1.97688277
44Midline defect of the nose (HP:0004122)1.96648982
45Absent frontal sinuses (HP:0002688)1.96609218
46Missing ribs (HP:0000921)1.94245305
47Scapular winging (HP:0003691)1.93806212
48Hypoplastic ischia (HP:0003175)1.93422716
49Alacrima (HP:0000522)1.93296329
50Preaxial foot polydactyly (HP:0001841)1.93179988
51Atrophic scars (HP:0001075)1.92468782
52Papillary thyroid carcinoma (HP:0002895)1.89919628
53Aplasia/Hypoplasia of the uvula (HP:0010293)1.88190529
54Transitional cell carcinoma of the bladder (HP:0006740)1.88158674
55Abnormality of the distal phalanx of the thumb (HP:0009617)1.86017334
56Bell-shaped thorax (HP:0001591)1.85523341
57True hermaphroditism (HP:0010459)1.84955539
58Hypoplasia of the maxilla (HP:0000327)1.84369810
59Thin bony cortex (HP:0002753)1.84078008
60Disproportionate tall stature (HP:0001519)1.83808580
61Limited hip movement (HP:0008800)1.83807452
62Short nail (HP:0001799)1.82575827
63Facial hemangioma (HP:0000329)1.81323513
64Coronal craniosynostosis (HP:0004440)1.81012940
65Abnormality of incisor morphology (HP:0011063)1.80510105
66Asymmetry of the thorax (HP:0001555)1.79267934
67Protrusio acetabuli (HP:0003179)1.76956793
68Osteolytic defects of the phalanges of the hand (HP:0009771)1.76908576
69Osteolytic defects of the hand bones (HP:0009699)1.76908576
70Coarse hair (HP:0002208)1.76306251
71Tubular atrophy (HP:0000092)1.75410932
72Exostoses (HP:0100777)1.75272233
73Insidious onset (HP:0003587)1.74989366
74Termporal pattern (HP:0011008)1.74989366
75Embryonal renal neoplasm (HP:0011794)1.74754033
76Abnormal biliary tract morphology (HP:0012440)1.74423026
77Thick nail (HP:0001805)1.73436375
78Dilatation of the ascending aorta (HP:0005111)1.73237872
79Pancreatic cysts (HP:0001737)1.73035322
80Adrenal hypoplasia (HP:0000835)1.72521047
81Bundle branch block (HP:0011710)1.72503252
82Submucous cleft hard palate (HP:0000176)1.72297575
83Oligodactyly (hands) (HP:0001180)1.71982137
84Renal cortical cysts (HP:0000803)1.70405607
85Abnormality of the calf musculature (HP:0001430)1.69877264
86Deviation of the hallux (HP:0010051)1.69006582
87Abnormality of the renal cortex (HP:0011035)1.68582023
88Hepatoblastoma (HP:0002884)1.68484574
89Buphthalmos (HP:0000557)1.68397286
90Bladder diverticulum (HP:0000015)1.68072996
91Soft skin (HP:0000977)1.67478903
92Ureteral obstruction (HP:0006000)1.67315991
93Trigonocephaly (HP:0000243)1.67257740
94Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.67246689
95Abnormality of dentin (HP:0010299)1.67045479
96Retinal atrophy (HP:0001105)1.66576028
97Decreased lacrimation (HP:0000633)1.66363247
98Abnormal auditory evoked potentials (HP:0006958)1.66053899
99Rectal prolapse (HP:0002035)1.65732439
100Disinhibition (HP:0000734)1.65674470
101Abnormality of chromosome stability (HP:0003220)1.65666050
102Labial hypoplasia (HP:0000066)1.64919356
103Striae distensae (HP:0001065)1.64411787
104Meckel diverticulum (HP:0002245)1.64054513
105Ankyloglossia (HP:0010296)1.63896634
106Abnormality of the fingertips (HP:0001211)1.63842621
107Follicular hyperkeratosis (HP:0007502)1.63526433
108Pancreatic fibrosis (HP:0100732)1.63311447
109Widely spaced teeth (HP:0000687)1.62488949
110Neoplasm of the adrenal cortex (HP:0100641)1.62464863
111Nephronophthisis (HP:0000090)1.62446558
112Abnormality of the ileum (HP:0001549)1.62371629
113Femoral bowing (HP:0002980)1.62113006
114Hallux valgus (HP:0001822)1.61696257
115Aplasia/Hypoplasia of the tongue (HP:0010295)1.61630897
116Broad thumb (HP:0011304)1.61541548
117Cutaneous finger syndactyly (HP:0010554)1.60910815
118Wormian bones (HP:0002645)1.60813427
119Thyroid carcinoma (HP:0002890)1.60427716
120Bronchomalacia (HP:0002780)1.59921680
121Oligodactyly (HP:0012165)1.59597897
122Knee flexion contracture (HP:0006380)1.59110243
123Overgrowth (HP:0001548)1.57679436
124Aplasia/Hypoplasia of the tibia (HP:0005772)1.57606922
125Abnormality of the peritoneum (HP:0002585)1.57458019
126Cervical subluxation (HP:0003308)1.57122662
127Microglossia (HP:0000171)1.57074643
128Abnormality of the frontal sinuses (HP:0002687)1.55831426
129Chorioretinal atrophy (HP:0000533)1.55025282
130High pitched voice (HP:0001620)1.54997049
131Camptodactyly of toe (HP:0001836)1.54940527
132Ankle contracture (HP:0006466)1.54480683
133Exotropia (HP:0000577)1.54294330
134Pheochromocytoma (HP:0002666)1.53642606
135Abnormality of the renal medulla (HP:0100957)1.53001667
136Abnormality of the carotid arteries (HP:0005344)1.52910637
137Thick eyebrow (HP:0000574)1.52481040
138Anteriorly placed anus (HP:0001545)1.51893659
139Hypoplasia of the iris (HP:0007676)1.51738171
140Turricephaly (HP:0000262)1.51738052
141Nephroblastoma (Wilms tumor) (HP:0002667)1.51486870
142Uterine leiomyosarcoma (HP:0002891)1.51089946
143Leiomyosarcoma (HP:0100243)1.51089946
144Genetic anticipation (HP:0003743)1.50943281
145Pulmonic stenosis (HP:0001642)1.49357990
146Enlarged kidneys (HP:0000105)1.47979542
147Vertebral clefting (HP:0008428)1.47642501
148Breast carcinoma (HP:0003002)1.47637781
149Hip contracture (HP:0003273)1.47373723
150Duodenal stenosis (HP:0100867)1.47155554
151Small intestinal stenosis (HP:0012848)1.47155554
152Pterygium (HP:0001059)1.46306390
153Neoplasm of the small intestine (HP:0100833)1.45186691
154Biliary tract neoplasm (HP:0100574)1.44645621
155Cutaneous syndactyly (HP:0012725)1.41659503
156Short tibia (HP:0005736)1.41416499
157Cystic hygroma (HP:0000476)1.39758107
158Wide anterior fontanel (HP:0000260)1.38678716
159Neonatal short-limb short stature (HP:0008921)1.38530609
160Glioma (HP:0009733)1.35909553
161Anophthalmia (HP:0000528)1.35244455
162Benign neoplasm of the central nervous system (HP:0100835)1.34131545
163Bowel diverticulosis (HP:0005222)1.34103694
164Increased corneal curvature (HP:0100692)1.33751080
165Keratoconus (HP:0000563)1.33751080
166Popliteal pterygium (HP:0009756)1.33499614
167Fibular hypoplasia (HP:0003038)1.33427891
168Abnormality of the intrinsic pathway (HP:0010989)1.32921373
169Abnormal lung lobation (HP:0002101)1.32284969
170Abnormality of the duodenum (HP:0002246)1.31961665
171Fragile skin (HP:0001030)1.31329938
172Postaxial foot polydactyly (HP:0001830)1.30888974
173Lipoatrophy (HP:0100578)1.30877735
174Abnormal sex determination (HP:0012244)1.30823031

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.12320237
2TGFBR23.20645994
3FRK2.85442990
4FGFR22.66240467
5CAMK1G2.47362180
6PNCK2.40866758
7CAMK1D2.40570145
8EIF2AK32.24682872
9STK38L2.20644216
10WEE12.07605756
11FGFR31.96112335
12MAP3K131.94092042
13STK391.93677357
14DMPK1.92434375
15BRSK21.92141030
16PINK11.89041775
17STK31.78694569
18TTN1.71864697
19SIK11.71121729
20EIF2AK11.70849845
21NUAK11.70745780
22TSSK61.65876386
23LATS21.65724365
24NEK91.65052388
25AKT31.63696907
26DDR21.62062401
27MAP3K21.60023087
28BMPR1B1.57529531
29INSRR1.56909138
30TTK1.51121510
31PTK61.50207294
32PDGFRA1.49269548
33OBSCN1.47367376
34NTRK31.45541071
35MKNK21.44499354
36FLT31.41862392
37NEK11.41241329
38PBK1.40121357
39RET1.36921060
40MYLK1.36788676
41WNK11.35014335
42CDK121.34331192
43CDK61.33017185
44NEK21.27859328
45KSR21.24741452
46MST1R1.23713951
47PIK3CA1.21377975
48SGK21.21199159
49MKNK11.20261516
50TIE11.19560228
51WNK41.18289050
52LMTK21.18267684
53PLK31.16577209
54MAP3K61.16081731
55SGK31.15044803
56PLK41.13143804
57MET1.08914546
58PDGFRB1.05327883
59GRK71.01733170
60TNIK1.01560547
61WNK30.98761179
62BRD40.98332992
63BCR0.98102196
64TRIM280.96719802
65RIPK10.96463120
66BUB10.93256720
67MELK0.92157307
68EPHA30.91469713
69SRPK10.88972336
70JAK10.88128318
71EIF2AK20.87729660
72KSR10.86317782
73ERBB40.86185346
74MAP3K40.85515529
75MAP3K120.85362549
76EPHB20.83731489
77ERBB30.81434205
78PLK10.79844327
79FER0.78535304
80ACVR1B0.76466848
81MAP3K90.75877763
82STK240.74716863
83PRKCH0.74608026
84PAK60.74373197
85STK100.74313629
86MOS0.73857164
87CDK90.73650995
88RPS6KB20.73023807
89CLK10.72959973
90FGFR10.72622314
91EPHA20.72293497
92PRKAA20.72276447
93PAK30.71425688
94OXSR10.70775342
95MST40.70433258
96MAPK150.69718596
97JAK20.69508020
98SGK4940.68945064
99SGK2230.68945064
100ZAK0.68938081
101TLK10.68264600
102CSNK1G10.68056776
103PAK20.67850649
104TRPM70.67706912
105CASK0.67279531
106PLK20.65151583
107NTRK10.64067252
108BMX0.63973995
109CDK30.63327317
110SGK10.63099515
111EEF2K0.62424680
112CSNK1A1L0.61984819
113AURKB0.61438143
114MAPKAPK50.60887073
115IGF1R0.59135465
116BRSK10.58727832
117TGFBR10.58384508
118ATM0.57591624
119MAP4K20.55484732
120ERBB20.53466865
121CAMK2D0.53361502
122CHEK20.53342217
123MTOR0.52590471
124INSR0.52185173
125SCYL20.51835908
126MAP3K70.50782243
127YES10.50235804
128CSNK1G20.49788222
129EPHB10.49362146
130MAPKAPK30.49088505
131PAK40.48933508
132NEK60.48679372
133GSK3A0.48308058
134HIPK20.47766227
135PRKCE0.46226974
136AKT20.45652384
137EGFR0.45272977
138EPHA40.44630072
139CSF1R0.44493866
140PKN20.44415162
141RPS6KB10.44361014
142MARK30.43385995
143MAP2K10.43370652
144TYK20.42708043
145PHKG10.41082048
146PHKG20.41082048
147TRIB30.40733567
148TAF10.40574669
149PTK20.40344143
150STK380.39967881
151CAMKK20.39617576
152CDC42BPA0.38786708
153PRKD10.37959717
154CDC70.37933324
155ROCK20.37872156
156STK110.37645751
157ROCK10.37128431
158MAPK70.36875822
159CSNK1D0.36800349
160RPS6KA20.35994872
161ADRBK10.35806313

Predicted pathways (KEGG)

RankGene SetZ-score
1Selenocompound metabolism_Homo sapiens_hsa004502.11452289
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.98110783
3Adherens junction_Homo sapiens_hsa045201.80569313
4Propanoate metabolism_Homo sapiens_hsa006401.79801270
5Protein export_Homo sapiens_hsa030601.77726228
6Fanconi anemia pathway_Homo sapiens_hsa034601.67654786
7Non-homologous end-joining_Homo sapiens_hsa034501.60385106
8Dorso-ventral axis formation_Homo sapiens_hsa043201.54656724
9Nitrogen metabolism_Homo sapiens_hsa009101.54231414
10Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.49568417
11Steroid biosynthesis_Homo sapiens_hsa001001.47581596
12Focal adhesion_Homo sapiens_hsa045101.46024773
13Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.44645897
14Basal transcription factors_Homo sapiens_hsa030221.43901198
15Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.41385744
16ECM-receptor interaction_Homo sapiens_hsa045121.40937303
17Proteoglycans in cancer_Homo sapiens_hsa052051.40626669
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.36426291
19Renal cell carcinoma_Homo sapiens_hsa052111.35487694
20Pancreatic cancer_Homo sapiens_hsa052121.34376234
21Butanoate metabolism_Homo sapiens_hsa006501.33076690
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.28628682
23Chronic myeloid leukemia_Homo sapiens_hsa052201.28411797
24Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.28179066
25Prostate cancer_Homo sapiens_hsa052151.28035595
26Type II diabetes mellitus_Homo sapiens_hsa049301.27267544
27Dilated cardiomyopathy_Homo sapiens_hsa054141.25062637
28Glycosaminoglycan degradation_Homo sapiens_hsa005311.24984894
29Glioma_Homo sapiens_hsa052141.23754950
30Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.23424832
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.22755746
32One carbon pool by folate_Homo sapiens_hsa006701.17973323
33Renin secretion_Homo sapiens_hsa049241.16115978
34Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.16110762
35MicroRNAs in cancer_Homo sapiens_hsa052061.14745621
36Nucleotide excision repair_Homo sapiens_hsa034201.13793193
37Circadian rhythm_Homo sapiens_hsa047101.12143290
38Pyruvate metabolism_Homo sapiens_hsa006201.11501836
39AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.11199124
40Vitamin B6 metabolism_Homo sapiens_hsa007501.10603876
41mTOR signaling pathway_Homo sapiens_hsa041501.10587358
42Protein digestion and absorption_Homo sapiens_hsa049741.10279000
43Endometrial cancer_Homo sapiens_hsa052131.09034904
44Maturity onset diabetes of the young_Homo sapiens_hsa049501.08554241
45Colorectal cancer_Homo sapiens_hsa052101.07534511
46Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.07204918
47TGF-beta signaling pathway_Homo sapiens_hsa043501.06747914
48Tight junction_Homo sapiens_hsa045301.06511981
49Steroid hormone biosynthesis_Homo sapiens_hsa001401.05817407
50Small cell lung cancer_Homo sapiens_hsa052221.04946989
51Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.04342879
52Melanoma_Homo sapiens_hsa052181.02738182
53Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.02120509
54ErbB signaling pathway_Homo sapiens_hsa040121.01845060
55Cysteine and methionine metabolism_Homo sapiens_hsa002700.99970068
56Basal cell carcinoma_Homo sapiens_hsa052170.99616618
57Homologous recombination_Homo sapiens_hsa034400.99188055
58Osteoclast differentiation_Homo sapiens_hsa043800.98380013
59Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.97784524
60Cell cycle_Homo sapiens_hsa041100.97450933
61Fatty acid metabolism_Homo sapiens_hsa012120.95780268
62Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95636660
63Toxoplasmosis_Homo sapiens_hsa051450.95021691
64Axon guidance_Homo sapiens_hsa043600.94358440
65Amoebiasis_Homo sapiens_hsa051460.93958141
66Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.93949053
67Regulation of actin cytoskeleton_Homo sapiens_hsa048100.92668193
68FoxO signaling pathway_Homo sapiens_hsa040680.92529781
69Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.91139362
70Fatty acid degradation_Homo sapiens_hsa000710.90557478
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.90407429
72Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.89880553
73Toll-like receptor signaling pathway_Homo sapiens_hsa046200.89843734
74Salivary secretion_Homo sapiens_hsa049700.89795419
75Estrogen signaling pathway_Homo sapiens_hsa049150.89120378
76Non-small cell lung cancer_Homo sapiens_hsa052230.88717493
77Staphylococcus aureus infection_Homo sapiens_hsa051500.86938583
78Lysine degradation_Homo sapiens_hsa003100.86629904
79Hippo signaling pathway_Homo sapiens_hsa043900.86139457
80RNA transport_Homo sapiens_hsa030130.85243387
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.85123089
82Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.84617828
83Lysosome_Homo sapiens_hsa041420.84394061
84Leukocyte transendothelial migration_Homo sapiens_hsa046700.84207339
85Prolactin signaling pathway_Homo sapiens_hsa049170.83911207
86cGMP-PKG signaling pathway_Homo sapiens_hsa040220.83088745
87Histidine metabolism_Homo sapiens_hsa003400.83061341
88Choline metabolism in cancer_Homo sapiens_hsa052310.83003825
89Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.82684720
90Platelet activation_Homo sapiens_hsa046110.82525916
91Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.82226603
92cAMP signaling pathway_Homo sapiens_hsa040240.82027180
93Rap1 signaling pathway_Homo sapiens_hsa040150.81892154
94Hedgehog signaling pathway_Homo sapiens_hsa043400.81809487
95Sulfur metabolism_Homo sapiens_hsa009200.81489672
96GnRH signaling pathway_Homo sapiens_hsa049120.81089542
97Melanogenesis_Homo sapiens_hsa049160.80415035
98Primary bile acid biosynthesis_Homo sapiens_hsa001200.80252566
99Neurotrophin signaling pathway_Homo sapiens_hsa047220.79969161
100Tryptophan metabolism_Homo sapiens_hsa003800.79687317
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.79354720
102Fatty acid biosynthesis_Homo sapiens_hsa000610.79144447
103Insulin resistance_Homo sapiens_hsa049310.78601409
104Wnt signaling pathway_Homo sapiens_hsa043100.78528209
105Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.77435914
106MAPK signaling pathway_Homo sapiens_hsa040100.77155373
107Phospholipase D signaling pathway_Homo sapiens_hsa040720.76311448
108Gastric acid secretion_Homo sapiens_hsa049710.76090591
109Long-term potentiation_Homo sapiens_hsa047200.75949522
110Viral myocarditis_Homo sapiens_hsa054160.75811229
111Ras signaling pathway_Homo sapiens_hsa040140.75642581
112RNA degradation_Homo sapiens_hsa030180.75203485
113Pathways in cancer_Homo sapiens_hsa052000.75090644
114Cholinergic synapse_Homo sapiens_hsa047250.74784339
115Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74598240
116Long-term depression_Homo sapiens_hsa047300.73872835
117Pentose and glucuronate interconversions_Homo sapiens_hsa000400.73730891
118Retinol metabolism_Homo sapiens_hsa008300.73600697
119Inositol phosphate metabolism_Homo sapiens_hsa005620.73329407
120N-Glycan biosynthesis_Homo sapiens_hsa005100.72976845
121Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.72510062
122Ovarian steroidogenesis_Homo sapiens_hsa049130.72281833
123Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71434493
124Oxytocin signaling pathway_Homo sapiens_hsa049210.70572775
125Chemical carcinogenesis_Homo sapiens_hsa052040.69385377
126Sphingolipid metabolism_Homo sapiens_hsa006000.69135312
127Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.68387914
128Aldosterone synthesis and secretion_Homo sapiens_hsa049250.67705973
129Gap junction_Homo sapiens_hsa045400.67244505
130Chemokine signaling pathway_Homo sapiens_hsa040620.66475139
131Thyroid hormone synthesis_Homo sapiens_hsa049180.65742540
132Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.65189222
133Leishmaniasis_Homo sapiens_hsa051400.64729342
134PI3K-Akt signaling pathway_Homo sapiens_hsa041510.64256756
135Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63601672
136Peroxisome_Homo sapiens_hsa041460.62992553
137Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.62737685
138TNF signaling pathway_Homo sapiens_hsa046680.62455430
139Hepatitis B_Homo sapiens_hsa051610.62116261
140ABC transporters_Homo sapiens_hsa020100.61880016
141Insulin secretion_Homo sapiens_hsa049110.61759052
142p53 signaling pathway_Homo sapiens_hsa041150.61571610
143Mismatch repair_Homo sapiens_hsa034300.61044562
144Sphingolipid signaling pathway_Homo sapiens_hsa040710.61042092
145Oocyte meiosis_Homo sapiens_hsa041140.60930256
146beta-Alanine metabolism_Homo sapiens_hsa004100.60598445
147Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60275884
148Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59365404
149Endocytosis_Homo sapiens_hsa041440.58848363
150Morphine addiction_Homo sapiens_hsa050320.58579179
151Circadian entrainment_Homo sapiens_hsa047130.58044463
152Thyroid cancer_Homo sapiens_hsa052160.57762913
153Tuberculosis_Homo sapiens_hsa051520.57519398
154B cell receptor signaling pathway_Homo sapiens_hsa046620.57302026
155Bladder cancer_Homo sapiens_hsa052190.57091264
156Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.56918547
157Vascular smooth muscle contraction_Homo sapiens_hsa042700.56763837
158Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.51237300
159Fatty acid elongation_Homo sapiens_hsa000620.50149047
160Arginine and proline metabolism_Homo sapiens_hsa003300.48944976
161Bile secretion_Homo sapiens_hsa049760.45505724
162Arginine biosynthesis_Homo sapiens_hsa002200.44887779
163Pancreatic secretion_Homo sapiens_hsa049720.44627223
164mRNA surveillance pathway_Homo sapiens_hsa030150.43848438
165Glutathione metabolism_Homo sapiens_hsa004800.42743150
166Phototransduction_Homo sapiens_hsa047440.42678798
167Glucagon signaling pathway_Homo sapiens_hsa049220.41172860

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