DPY30

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an integral core subunit of the SET1/MLL family of H3K4 methyltransferases. The encoded protein directly controls cell cycle regulators and plays an important role in the proliferation and differentiation of human hematopoietic progenitor cells. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.20012844
2ATP synthesis coupled proton transport (GO:0015986)6.15980230
3energy coupled proton transport, down electrochemical gradient (GO:0015985)6.15980230
4chaperone-mediated protein transport (GO:0072321)5.59361061
5mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.27406214
6establishment of protein localization to mitochondrial membrane (GO:0090151)5.10391025
7respiratory electron transport chain (GO:0022904)4.96763947
8electron transport chain (GO:0022900)4.88541463
9ribosomal small subunit assembly (GO:0000028)4.67455516
10DNA strand elongation involved in DNA replication (GO:0006271)4.63786949
11telomere maintenance via semi-conservative replication (GO:0032201)4.61427513
12DNA deamination (GO:0045006)4.59470548
13protein complex biogenesis (GO:0070271)4.55312610
14protein neddylation (GO:0045116)4.46090540
15CENP-A containing nucleosome assembly (GO:0034080)4.43321746
16DNA strand elongation (GO:0022616)4.41651057
17chromatin remodeling at centromere (GO:0031055)4.41580575
18mitochondrial respiratory chain complex assembly (GO:0033108)4.37854586
19DNA replication checkpoint (GO:0000076)4.37724417
20DNA replication initiation (GO:0006270)4.32588626
21mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.28516479
22mitochondrial respiratory chain complex I assembly (GO:0032981)4.28516479
23NADH dehydrogenase complex assembly (GO:0010257)4.28516479
24mitotic metaphase plate congression (GO:0007080)4.25985302
25telomere maintenance via recombination (GO:0000722)4.25233126
26proteasome assembly (GO:0043248)4.22268502
27maturation of SSU-rRNA (GO:0030490)4.18956915
28formation of translation preinitiation complex (GO:0001731)4.11267695
29purine nucleobase biosynthetic process (GO:0009113)3.94969849
30rRNA modification (GO:0000154)3.94686389
31respiratory chain complex IV assembly (GO:0008535)3.94030875
32mitotic recombination (GO:0006312)3.92681998
33nucleobase biosynthetic process (GO:0046112)3.92574815
34DNA replication-independent nucleosome organization (GO:0034724)3.88041096
35DNA replication-independent nucleosome assembly (GO:0006336)3.88041096
36regulation of mitochondrial translation (GO:0070129)3.85141539
37kinetochore assembly (GO:0051382)3.84979738
38kinetochore organization (GO:0051383)3.83765264
39attachment of spindle microtubules to kinetochore (GO:0008608)3.78968101
40telomere maintenance via telomere lengthening (GO:0010833)3.75232199
41metaphase plate congression (GO:0051310)3.72397502
42ribosomal large subunit biogenesis (GO:0042273)3.72117467
43ribosomal small subunit biogenesis (GO:0042274)3.72091920
44establishment of protein localization to endoplasmic reticulum (GO:0072599)3.69104633
45negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.63786651
46cytochrome complex assembly (GO:0017004)3.63064529
47spliceosomal snRNP assembly (GO:0000387)3.62918752
48DNA damage response, detection of DNA damage (GO:0042769)3.60273140
49histone exchange (GO:0043486)3.59962245
50ribonucleoprotein complex biogenesis (GO:0022613)3.57647150
51anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.57619561
52viral transcription (GO:0019083)3.57047741
53transcription-coupled nucleotide-excision repair (GO:0006283)3.56043505
54nucleotide-excision repair, DNA gap filling (GO:0006297)3.55933088
55maturation of 5.8S rRNA (GO:0000460)3.55574099
56translational termination (GO:0006415)3.55230989
57ribosome assembly (GO:0042255)3.54830332
58DNA replication-dependent nucleosome organization (GO:0034723)3.54667641
59DNA replication-dependent nucleosome assembly (GO:0006335)3.54667641
60regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.53873828
61ribosome biogenesis (GO:0042254)3.52351073
62deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.49416262
63positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.49039736
64viral mRNA export from host cell nucleus (GO:0046784)3.48832929
657-methylguanosine mRNA capping (GO:0006370)3.45739989
66rRNA processing (GO:0006364)3.42377817
67termination of RNA polymerase III transcription (GO:0006386)3.41718305
68transcription elongation from RNA polymerase III promoter (GO:0006385)3.41718305
69establishment of chromosome localization (GO:0051303)3.41560471
707-methylguanosine RNA capping (GO:0009452)3.39636170
71RNA capping (GO:0036260)3.39636170
72protein targeting to mitochondrion (GO:0006626)3.38372947
73ATP biosynthetic process (GO:0006754)3.37685754
74regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.37669915
75negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.33488016
76negative regulation of ligase activity (GO:0051352)3.33488016
77establishment of integrated proviral latency (GO:0075713)3.33345200
78pseudouridine synthesis (GO:0001522)3.32602174
79rRNA metabolic process (GO:0016072)3.29822845
80translational elongation (GO:0006414)3.29785811
81protein localization to kinetochore (GO:0034501)3.29428578
82water-soluble vitamin biosynthetic process (GO:0042364)3.28019966
83rRNA methylation (GO:0031167)3.27783519
84translational initiation (GO:0006413)3.26416072
85spliceosomal complex assembly (GO:0000245)3.26122252
86hydrogen ion transmembrane transport (GO:1902600)3.25887773
87inner mitochondrial membrane organization (GO:0007007)3.25029983
88protein localization to mitochondrion (GO:0070585)3.24905937
89purine nucleoside triphosphate biosynthetic process (GO:0009145)3.23972272
90protein deneddylation (GO:0000338)3.23715516
91cullin deneddylation (GO:0010388)3.22447478
92purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.22183897
93establishment of protein localization to mitochondrion (GO:0072655)3.21402127
94exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.21226568
95mitotic nuclear envelope disassembly (GO:0007077)3.20523458
96SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.19651853
97DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.19370621
98signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.16242591
99signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.16242591
100signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.16242591
101regulation of nuclear cell cycle DNA replication (GO:0033262)3.15450506
102intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.15231875
103signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.15231875
104RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.14649375
105tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.14649375
106translation (GO:0006412)3.13882645
107nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.13659373
108regulation of mitotic spindle checkpoint (GO:1903504)3.13121532
109regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.13121532
110cotranslational protein targeting to membrane (GO:0006613)3.12765799
111G1/S transition of mitotic cell cycle (GO:0000082)3.12700320
112cell cycle G1/S phase transition (GO:0044843)3.12700320
113IMP biosynthetic process (GO:0006188)3.12561440
114positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.10406502
115signal transduction involved in DNA integrity checkpoint (GO:0072401)3.10256532
116signal transduction involved in DNA damage checkpoint (GO:0072422)3.10256532
117regulation of double-strand break repair via homologous recombination (GO:0010569)3.09164579
118protein targeting to ER (GO:0045047)3.09036161
119L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.08303011
120signal transduction involved in cell cycle checkpoint (GO:0072395)3.06806279
121cellular protein complex disassembly (GO:0043624)3.05877899
122viral life cycle (GO:0019058)3.05214530
123regulation of cellular amino acid metabolic process (GO:0006521)3.04895908
124cellular component biogenesis (GO:0044085)3.03775670
125DNA unwinding involved in DNA replication (GO:0006268)3.01970450
126intracellular protein transmembrane import (GO:0044743)3.01134839
127protein-cofactor linkage (GO:0018065)3.00955044
128nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.00498029
129deoxyribonucleotide biosynthetic process (GO:0009263)3.00114629
130mitotic sister chromatid segregation (GO:0000070)2.99336616
131meiotic chromosome segregation (GO:0045132)2.98934271
132transcription from RNA polymerase I promoter (GO:0006360)2.98325810
133protein localization to chromosome, centromeric region (GO:0071459)2.97330228
134oxidative phosphorylation (GO:0006119)2.96865548
135positive regulation of ligase activity (GO:0051351)2.95489025
136proton transport (GO:0015992)2.95479859
137DNA double-strand break processing (GO:0000729)2.95083468
138protein localization to endoplasmic reticulum (GO:0070972)2.94302037
139nuclear envelope disassembly (GO:0051081)2.90370049
140hydrogen transport (GO:0006818)2.88725299
141histone mRNA metabolic process (GO:0008334)2.88318618
142ribonucleoside triphosphate biosynthetic process (GO:0009201)2.87591438
143protein K6-linked ubiquitination (GO:0085020)2.85835639
144mitochondrial transport (GO:0006839)2.82471327
145regulation of ubiquitin-protein transferase activity (GO:0051438)2.77799608
146pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.75686975

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.49191669
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.37441162
3* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.08846394
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.58434797
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.54959010
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.49739685
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.48846178
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.44626671
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.13523263
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.11636439
11FOXM1_23109430_ChIP-Seq_U2OS_Human3.10974837
12MYC_18358816_ChIP-ChIP_MESCs_Mouse3.01150175
13CREB1_15753290_ChIP-ChIP_HEK293T_Human3.00709344
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.96551864
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.96245676
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.79761765
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.79423429
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.74108993
19VDR_23849224_ChIP-Seq_CD4+_Human2.45008159
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.39832594
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.39382066
22* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.36459248
23* XRN2_22483619_ChIP-Seq_HELA_Human2.31191468
24E2F1_18555785_ChIP-Seq_MESCs_Mouse2.29375427
25ELF1_17652178_ChIP-ChIP_JURKAT_Human2.20030751
26DCP1A_22483619_ChIP-Seq_HELA_Human2.19990896
27ZNF274_21170338_ChIP-Seq_K562_Hela2.19253805
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.09357774
29FOXP3_21729870_ChIP-Seq_TREG_Human2.09227901
30MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.07979542
31THAP11_20581084_ChIP-Seq_MESCs_Mouse2.03140076
32SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.00840514
33* GABP_19822575_ChIP-Seq_HepG2_Human1.98668928
34CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.96915447
35AR_21909140_ChIP-Seq_LNCAP_Human1.96206791
36NANOG_18555785_ChIP-Seq_MESCs_Mouse1.92262087
37YY1_21170310_ChIP-Seq_MESCs_Mouse1.91253887
38VDR_22108803_ChIP-Seq_LS180_Human1.89942122
39ELK1_19687146_ChIP-ChIP_HELA_Human1.89474061
40SRF_21415370_ChIP-Seq_HL-1_Mouse1.87402259
41TTF2_22483619_ChIP-Seq_HELA_Human1.87253398
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.86973925
43MYCN_18555785_ChIP-Seq_MESCs_Mouse1.84075926
44POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.81016017
45MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.79138915
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.78389833
47E2F1_21310950_ChIP-Seq_MCF-7_Human1.75923410
48EWS_26573619_Chip-Seq_HEK293_Human1.74482515
49FUS_26573619_Chip-Seq_HEK293_Human1.69647485
50ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.69450801
51SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.65830460
52* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.61911391
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.61875643
54PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.60070069
55POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.59965057
56POU5F1_16153702_ChIP-ChIP_HESCs_Human1.52474741
57FLI1_27457419_Chip-Seq_LIVER_Mouse1.45918288
58FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.45144224
59ZFX_18555785_ChIP-Seq_MESCs_Mouse1.43016064
60KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.41436851
61TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.37644659
62POU3F2_20337985_ChIP-ChIP_501MEL_Human1.34474939
63SOX2_16153702_ChIP-ChIP_HESCs_Human1.32640325
64POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.32429463
65KDM5A_27292631_Chip-Seq_BREAST_Human1.32160550
66FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.31240611
67SOX2_18555785_ChIP-Seq_MESCs_Mouse1.30593556
68CIITA_25753668_ChIP-Seq_RAJI_Human1.29790237
69NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.28085657
70NANOG_16153702_ChIP-ChIP_HESCs_Human1.27746231
71TAF15_26573619_Chip-Seq_HEK293_Human1.26667446
72* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.24354420
73PADI4_21655091_ChIP-ChIP_MCF-7_Human1.24095375
74P300_19829295_ChIP-Seq_ESCs_Human1.23706220
75HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.23269364
76ERG_20887958_ChIP-Seq_HPC-7_Mouse1.23188603
77CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.22963282
78CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21182940
79MYC_18940864_ChIP-ChIP_HL60_Human1.20210198
80TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.19957572
81IGF1R_20145208_ChIP-Seq_DFB_Human1.17340022
82RBPJ_22232070_ChIP-Seq_NCS_Mouse1.16471763
83SALL1_21062744_ChIP-ChIP_HESCs_Human1.16208061
84STAT3_1855785_ChIP-Seq_MESCs_Mouse1.16103096
85CTBP1_25329375_ChIP-Seq_LNCAP_Human1.15121541
86SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.14924370
87HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.14764517
88PCGF2_27294783_Chip-Seq_ESCs_Mouse1.14463422
89ZFP57_27257070_Chip-Seq_ESCs_Mouse1.13244850
90SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.11894938
91MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.11119943
92TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09503191
93TP53_22573176_ChIP-Seq_HFKS_Human1.08430807
94ELK1_22589737_ChIP-Seq_MCF10A_Human1.07985093
95KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.07895038
96EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.07837594
97E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07319278
98KLF4_18555785_ChIP-Seq_MESCs_Mouse1.05765165
99BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04840587
100CTBP2_25329375_ChIP-Seq_LNCAP_Human1.03968248
101GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02751833
102CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.01703233
103HTT_18923047_ChIP-ChIP_STHdh_Human0.98682544
104TP63_19390658_ChIP-ChIP_HaCaT_Human0.98021851
105FOXA1_25329375_ChIP-Seq_VCAP_Human0.97298957
106FOXA1_27270436_Chip-Seq_PROSTATE_Human0.97298957
107GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96472263
108NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.93967130
109NOTCH1_21737748_ChIP-Seq_TLL_Human0.93551074
110NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.93063712
111TFEB_21752829_ChIP-Seq_HELA_Human0.90536828
112CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.89244779
113NANOG_19829295_ChIP-Seq_ESCs_Human0.88493884
114SOX2_19829295_ChIP-Seq_ESCs_Human0.88493884
115IRF1_19129219_ChIP-ChIP_H3396_Human0.88155544
116TCF3_18692474_ChIP-Seq_MEFs_Mouse0.86880952
117AR_20517297_ChIP-Seq_VCAP_Human0.86401862
118SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.86231274
119ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.85665183
120SOX2_18692474_ChIP-Seq_MEFs_Mouse0.85604715
121BMI1_23680149_ChIP-Seq_NPCS_Mouse0.85011871
122* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.84049763
123NANOG_21062744_ChIP-ChIP_HESCs_Human0.83852782
124KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.83767870
125NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.83362057
126SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.81719353
127CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.81546032
128FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.81504961
129* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.81317418
130OCT4_18692474_ChIP-Seq_MEFs_Mouse0.79593058
131RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.79485311
132GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.78341481
133SOX17_20123909_ChIP-Seq_XEN_Mouse0.77996103
134KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.77155441
135KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.77155441
136KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.77155441
137DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.77111216
138ER_23166858_ChIP-Seq_MCF-7_Human0.76672403
139NFE2_27457419_Chip-Seq_LIVER_Mouse0.76531579
140GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.75000561

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.00829097
2MP0010094_abnormal_chromosome_stability4.68028061
3MP0004957_abnormal_blastocyst_morpholog4.63014005
4MP0003111_abnormal_nucleus_morphology4.31146549
5MP0003077_abnormal_cell_cycle4.08462228
6MP0008058_abnormal_DNA_repair3.88811513
7MP0008057_abnormal_DNA_replication3.74680740
8MP0008007_abnormal_cellular_replicative2.98008079
9MP0008932_abnormal_embryonic_tissue2.96136904
10MP0008877_abnormal_DNA_methylation2.67816733
11MP0003718_maternal_effect2.60704732
12MP0003806_abnormal_nucleotide_metabolis2.60055330
13MP0003123_paternal_imprinting2.42866269
14MP0006072_abnormal_retinal_apoptosis2.38571082
15MP0003786_premature_aging2.34647486
16MP0006292_abnormal_olfactory_placode2.04290361
17MP0003186_abnormal_redox_activity2.03330698
18MP0000350_abnormal_cell_proliferation2.02505153
19MP0001730_embryonic_growth_arrest2.02361899
20MP0000372_irregular_coat_pigmentation1.84155477
21MP0003011_delayed_dark_adaptation1.81952458
22MP0002396_abnormal_hematopoietic_system1.79751037
23MP0003315_abnormal_perineum_morphology1.77485973
24MP0002736_abnormal_nociception_after1.73397985
25MP0001984_abnormal_olfaction1.69833545
26MP0003880_abnormal_central_pattern1.66902684
27MP0008875_abnormal_xenobiotic_pharmacok1.63282782
28MP0009379_abnormal_foot_pigmentation1.62589241
29MP0000490_abnormal_crypts_of1.59572234
30MP0005084_abnormal_gallbladder_morpholo1.57927999
31MP0002638_abnormal_pupillary_reflex1.52524313
32MP0002837_dystrophic_cardiac_calcinosis1.51253861
33MP0002210_abnormal_sex_determination1.50552576
34MP0005551_abnormal_eye_electrophysiolog1.49444651
35MP0000631_abnormal_neuroendocrine_gland1.47826473
36MP0005253_abnormal_eye_physiology1.46040331
37MP0001697_abnormal_embryo_size1.44688801
38MP0004133_heterotaxia1.43882342
39MP0000313_abnormal_cell_death1.39960822
40MP0006036_abnormal_mitochondrial_physio1.39925934
41MP0001672_abnormal_embryogenesis/_devel1.39618878
42MP0005380_embryogenesis_phenotype1.39618878
43MP0002160_abnormal_reproductive_system1.36486511
44MP0003195_calcinosis1.34417402
45MP0001929_abnormal_gametogenesis1.34350687
46MP0003941_abnormal_skin_development1.33885978
47MP0002653_abnormal_ependyma_morphology1.33279650
48MP0001485_abnormal_pinna_reflex1.32662111
49MP0004142_abnormal_muscle_tone1.31100675
50MP0000566_synostosis1.29962933
51MP0002080_prenatal_lethality1.28952259
52MP0001145_abnormal_male_reproductive1.28945731
53MP0002085_abnormal_embryonic_tissue1.28558224
54MP0002019_abnormal_tumor_incidence1.27211192
55MP0001968_abnormal_touch/_nociception1.26942033
56MP0008789_abnormal_olfactory_epithelium1.26332863
57MP0003121_genomic_imprinting1.25580570
58MP0003787_abnormal_imprinting1.23268999
59MP0001905_abnormal_dopamine_level1.22761174
60MP0000653_abnormal_sex_gland1.21681833
61MP0005645_abnormal_hypothalamus_physiol1.21043541
62MP0003984_embryonic_growth_retardation1.20724007
63MP0005389_reproductive_system_phenotype1.19361090
64MP0008872_abnormal_physiological_respon1.17870966
65MP0006276_abnormal_autonomic_nervous1.17452874
66MP0001119_abnormal_female_reproductive1.17417396
67MP0003890_abnormal_embryonic-extraembry1.17375198
68MP0002132_abnormal_respiratory_system1.15968338
69MP0010030_abnormal_orbit_morphology1.15525200
70MP0002088_abnormal_embryonic_growth/wei1.15484294
71MP0003122_maternal_imprinting1.13393122
72MP0009333_abnormal_splenocyte_physiolog1.12113542
73MP0000049_abnormal_middle_ear1.11657827
74MP0009046_muscle_twitch1.10311010
75MP0002751_abnormal_autonomic_nervous1.08666366
76MP0002233_abnormal_nose_morphology1.06901110
77MP0001986_abnormal_taste_sensitivity1.05715602
78MP0000647_abnormal_sebaceous_gland1.05167811
79MP0010352_gastrointestinal_tract_polyps1.05015026
80MP0002084_abnormal_developmental_patter1.03923859
81MP0005646_abnormal_pituitary_gland1.03744016
82MP0003567_abnormal_fetal_cardiomyocyte1.02761388
83MP0010386_abnormal_urinary_bladder1.00316112
84MP0004147_increased_porphyrin_level0.99538363
85MP0006035_abnormal_mitochondrial_morpho0.98860840
86MP0001293_anophthalmia0.98044784
87MP0010307_abnormal_tumor_latency0.97490980
88MP0009697_abnormal_copulation0.97348139
89MP0002234_abnormal_pharynx_morphology0.96628916
90MP0005408_hypopigmentation0.95665862
91MP0002102_abnormal_ear_morphology0.93115721
92MP0002272_abnormal_nervous_system0.91610311
93MP0002086_abnormal_extraembryonic_tissu0.91412790
94MP0001529_abnormal_vocalization0.90464736
95MP0003763_abnormal_thymus_physiology0.90396453
96MP0009745_abnormal_behavioral_response0.90217049
97MP0003646_muscle_fatigue0.89895035
98MP0001545_abnormal_hematopoietic_system0.89887152
99MP0005397_hematopoietic_system_phenotyp0.89887152
100MP0000358_abnormal_cell_content/0.89800498
101MP0001919_abnormal_reproductive_system0.89733614
102MP0003136_yellow_coat_color0.88921977
103MP0004019_abnormal_vitamin_homeostasis0.87706805
104MP0005391_vision/eye_phenotype0.86573972
105MP0005195_abnormal_posterior_eye0.86144676
106MP0005394_taste/olfaction_phenotype0.85540592
107MP0005499_abnormal_olfactory_system0.85540592
108MP0003938_abnormal_ear_development0.84522704
109MP0005266_abnormal_metabolism0.84446614
110MP0002938_white_spotting0.84231777
111MP0002090_abnormal_vision0.83683415
112MP0005075_abnormal_melanosome_morpholog0.82975950
113MP0002163_abnormal_gland_morphology0.82874677
114MP0002282_abnormal_trachea_morphology0.81762959
115MP0004197_abnormal_fetal_growth/weight/0.80267118
116MP0001764_abnormal_homeostasis0.78820768
117MP0005379_endocrine/exocrine_gland_phen0.77762619
118MP0005332_abnormal_amino_acid0.77278926
119MP0000026_abnormal_inner_ear0.77112807
120MP0002697_abnormal_eye_size0.76492930
121MP0004808_abnormal_hematopoietic_stem0.75660357
122MP0002752_abnormal_somatic_nervous0.74592839
123MP0003698_abnormal_male_reproductive0.73935661
124MP0000703_abnormal_thymus_morphology0.73031823
125MP0002277_abnormal_respiratory_mucosa0.72852420
126MP0005395_other_phenotype0.69979261
127MP0002734_abnormal_mechanical_nocicepti0.69858862
128MP0003755_abnormal_palate_morphology0.69813655
129MP0003937_abnormal_limbs/digits/tail_de0.69548801
130MP0000858_altered_metastatic_potential0.68353112
131MP0001286_abnormal_eye_development0.67881068
132MP0005085_abnormal_gallbladder_physiolo0.67770222
133MP0004215_abnormal_myocardial_fiber0.67631444
134MP0002722_abnormal_immune_system0.67141532
135MP0000689_abnormal_spleen_morphology0.66615397
136MP0002398_abnormal_bone_marrow0.66459998
137MP0003699_abnormal_female_reproductive0.66118469
138MP0000678_abnormal_parathyroid_gland0.65753370
139MP0005384_cellular_phenotype0.65553838
140MP0002111_abnormal_tail_morphology0.64526990
141MP0003119_abnormal_digestive_system0.64372833
142MP0008260_abnormal_autophagy0.63658313
143MP0002161_abnormal_fertility/fecundity0.63003901
144MP0001188_hyperpigmentation0.58442435
145MP0002095_abnormal_skin_pigmentation0.56982754
146MP0002429_abnormal_blood_cell0.56679854
147MP0001853_heart_inflammation0.56591830
148MP0005451_abnormal_body_composition0.55277210
149MP0008995_early_reproductive_senescence0.54677115
150MP0004782_abnormal_surfactant_physiolog0.54215458

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.41727610
2Breast hypoplasia (HP:0003187)4.25684302
3Abnormality of cells of the erythroid lineage (HP:0012130)4.22216276
4Reticulocytopenia (HP:0001896)4.17600314
5Abnormal number of erythroid precursors (HP:0012131)4.10660593
6Oral leukoplakia (HP:0002745)3.88953395
7Chromsome breakage (HP:0040012)3.77707745
8Chromosomal breakage induced by crosslinking agents (HP:0003221)3.52163267
9Aplastic anemia (HP:0001915)3.50433121
10Carpal bone hypoplasia (HP:0001498)3.35288947
11Acute necrotizing encephalopathy (HP:0006965)3.30334979
12Cerebral edema (HP:0002181)3.28297862
13Patellar aplasia (HP:0006443)3.15908297
14Abnormality of the preputium (HP:0100587)3.12032303
15Rough bone trabeculation (HP:0100670)3.10597903
16Mitochondrial inheritance (HP:0001427)3.03313383
17Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.02311518
18Decreased activity of mitochondrial respiratory chain (HP:0008972)3.02311518
19Cerebral hypomyelination (HP:0006808)3.01548326
20Colon cancer (HP:0003003)3.00886235
21Aplasia/Hypoplasia of the patella (HP:0006498)2.98074590
22Abnormal mitochondria in muscle tissue (HP:0008316)2.97827260
23Meckel diverticulum (HP:0002245)2.96222499
24Degeneration of anterior horn cells (HP:0002398)2.95870541
25Abnormality of the anterior horn cell (HP:0006802)2.95870541
26Increased CSF lactate (HP:0002490)2.93508915
27Abnormality of chromosome stability (HP:0003220)2.93192392
28Hepatocellular necrosis (HP:0001404)2.92908025
29Abnormality of the ileum (HP:0001549)2.84065518
30Molar tooth sign on MRI (HP:0002419)2.82295265
31Abnormality of midbrain morphology (HP:0002418)2.82295265
32Macrocytic anemia (HP:0001972)2.80832984
33Congenital, generalized hypertrichosis (HP:0004540)2.77213739
34Increased intramyocellular lipid droplets (HP:0012240)2.73838801
35Aplasia/Hypoplasia of the sacrum (HP:0008517)2.70308776
36Increased serum lactate (HP:0002151)2.69344364
37Supernumerary spleens (HP:0009799)2.69316255
38Absent thumb (HP:0009777)2.68736626
39Hepatic necrosis (HP:0002605)2.68612697
40Aplasia/Hypoplasia of the uvula (HP:0010293)2.66038962
41Septo-optic dysplasia (HP:0100842)2.65349547
42Methylmalonic acidemia (HP:0002912)2.65151501
43Acute encephalopathy (HP:0006846)2.63711778
44Increased hepatocellular lipid droplets (HP:0006565)2.61919175
45Impulsivity (HP:0100710)2.57242267
46Absent radius (HP:0003974)2.55484348
47Pallor (HP:0000980)2.51945903
48Optic disc pallor (HP:0000543)2.51117627
49Premature graying of hair (HP:0002216)2.51048241
50Medulloblastoma (HP:0002885)2.50558328
51Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.49477350
52Medial flaring of the eyebrow (HP:0010747)2.48143714
53Microretrognathia (HP:0000308)2.47050612
54Progressive macrocephaly (HP:0004481)2.46222380
55Bone marrow hypocellularity (HP:0005528)2.45571985
563-Methylglutaconic aciduria (HP:0003535)2.45029284
57Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.41221094
58Type I transferrin isoform profile (HP:0003642)2.40927484
59Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.38772914
60Agnosia (HP:0010524)2.38250052
61Leukodystrophy (HP:0002415)2.36272376
6211 pairs of ribs (HP:0000878)2.36005908
63Absent forearm bone (HP:0003953)2.35137190
64Aplasia involving forearm bones (HP:0009822)2.35137190
65Abnormality of renal resorption (HP:0011038)2.35066064
66Abnormal respiratory motile cilium physiology (HP:0012261)2.33489593
67Hyperglycinemia (HP:0002154)2.33038263
68Abnormal trabecular bone morphology (HP:0100671)2.32699095
69Nephronophthisis (HP:0000090)2.32528697
70Horseshoe kidney (HP:0000085)2.31605421
71Abnormality of the renal collecting system (HP:0004742)2.31218571
72Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.31208083
73Myelodysplasia (HP:0002863)2.31120530
74Secondary amenorrhea (HP:0000869)2.30798651
75Duplicated collecting system (HP:0000081)2.28543943
76Duodenal stenosis (HP:0100867)2.28314354
77Small intestinal stenosis (HP:0012848)2.28314354
78Exertional dyspnea (HP:0002875)2.27997096
79Abnormality of the labia minora (HP:0012880)2.26841995
80Methylmalonic aciduria (HP:0012120)2.25745470
81Lipid accumulation in hepatocytes (HP:0006561)2.25003620
82Lethargy (HP:0001254)2.24230327
83Cleft eyelid (HP:0000625)2.24160126
84Selective tooth agenesis (HP:0001592)2.23162028
85Abnormal respiratory epithelium morphology (HP:0012253)2.23151692
86Abnormal respiratory motile cilium morphology (HP:0005938)2.23151692
87Abnormal lung lobation (HP:0002101)2.22760147
88Cellular immunodeficiency (HP:0005374)2.22565289
89Exercise intolerance (HP:0003546)2.19704051
90Abnormal ciliary motility (HP:0012262)2.18870393
91Sclerocornea (HP:0000647)2.18557566
92Sloping forehead (HP:0000340)2.17333156
93Triphalangeal thumb (HP:0001199)2.16488587
94Pancytopenia (HP:0001876)2.15256093
95Premature ovarian failure (HP:0008209)2.14897092
96Microvesicular hepatic steatosis (HP:0001414)2.13034964
97Increased muscle lipid content (HP:0009058)2.12170396
98Pancreatic cysts (HP:0001737)2.12081562
99Abnormality of urine glucose concentration (HP:0011016)2.10801687
100Glycosuria (HP:0003076)2.10801687
101Trismus (HP:0000211)2.09625124
102Absent septum pellucidum (HP:0001331)2.09052405
103Pancreatic fibrosis (HP:0100732)2.08559440
104Congenital primary aphakia (HP:0007707)2.07843146
105Multiple enchondromatosis (HP:0005701)2.06593243
106Muscle fiber atrophy (HP:0100295)2.06186933
107Rhinitis (HP:0012384)2.05462038
108Type 2 muscle fiber atrophy (HP:0003554)2.04528433
109Neoplasm of the pancreas (HP:0002894)2.01019855
110Tracheoesophageal fistula (HP:0002575)2.00931305
111Stenosis of the external auditory canal (HP:0000402)2.00863733
112Gait imbalance (HP:0002141)2.00311902
113Lactic acidosis (HP:0003128)1.98789307
114Abnormality of methionine metabolism (HP:0010901)1.97712639
115Megaloblastic anemia (HP:0001889)1.97566876
116True hermaphroditism (HP:0010459)1.97188580
117Increased serum pyruvate (HP:0003542)1.95026221
118Abnormality of glycolysis (HP:0004366)1.95026221
119Sparse eyelashes (HP:0000653)1.93090867
120Abnormality of serum amino acid levels (HP:0003112)1.92954829
121Respiratory failure (HP:0002878)1.92479279
122Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.92202212
123Hypothermia (HP:0002045)1.91760870
124Aplasia/Hypoplasia of the tongue (HP:0010295)1.91196822
125Anencephaly (HP:0002323)1.90861354
126CNS demyelination (HP:0007305)1.89832595
127Abnormality of the duodenum (HP:0002246)1.89474101
128Ectopic kidney (HP:0000086)1.89049157
129Abnormality of aspartate family amino acid metabolism (HP:0010899)1.88852716
130Nephrogenic diabetes insipidus (HP:0009806)1.88308495
131Genital tract atresia (HP:0001827)1.88253207
132Hyperphosphaturia (HP:0003109)1.87247645
133Hypoplasia of the radius (HP:0002984)1.86085194
134Rhabdomyosarcoma (HP:0002859)1.85257843
135Male pseudohermaphroditism (HP:0000037)1.84913343
136Vaginal atresia (HP:0000148)1.84893552
137Pulmonary fibrosis (HP:0002206)1.84883187
138Optic nerve hypoplasia (HP:0000609)1.84368355
139Absent/shortened dynein arms (HP:0200106)1.83408921
140Dynein arm defect of respiratory motile cilia (HP:0012255)1.83408921
141CNS hypomyelination (HP:0003429)1.81152515
142Respiratory difficulties (HP:0002880)1.81114958
143Renal Fanconi syndrome (HP:0001994)1.81102658
144Irregular epiphyses (HP:0010582)1.79947371
145Pendular nystagmus (HP:0012043)1.79740694
146Hypoplasia of the pons (HP:0012110)1.78399703
147Adrenal hypoplasia (HP:0000835)1.78010936
148Abnormality of the pons (HP:0007361)1.77288985
149Chronic bronchitis (HP:0004469)1.77034173
150Abnormal protein glycosylation (HP:0012346)1.73708621
151Abnormal glycosylation (HP:0012345)1.73708621
152Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.73708621
153Abnormal protein N-linked glycosylation (HP:0012347)1.73708621
154Abnormality of the septum pellucidum (HP:0007375)1.72670999
155Abnormality of the renal medulla (HP:0100957)1.72163371

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.46307573
2NEK14.09197187
3WEE14.07475679
4VRK23.83071331
5PLK43.39469913
6CDC73.36525903
7EIF2AK13.26160546
8STK163.17748007
9SRPK12.85763520
10NEK22.62290642
11VRK12.48975810
12TTK2.37291301
13EIF2AK32.32885874
14WNK32.31924230
15NME22.18517646
16TRIM282.18271288
17PLK11.98635883
18ACVR1B1.95614308
19MAP4K21.94262020
20TSSK61.91767944
21BRSK21.91272377
22ZAK1.65792305
23PLK31.61316647
24AURKB1.60387694
25TNIK1.50989551
26PBK1.50823337
27TAF11.50324445
28TESK21.49236576
29RPS6KB21.47621604
30MKNK11.43602933
31ATR1.42530691
32FRK1.40159487
33CHEK21.39052219
34DYRK31.38358800
35CDK71.37730890
36CCNB11.37436813
37STK38L1.37268398
38AURKA1.37050908
39TLK11.35584120
40GRK11.32462884
41MST41.32414199
42BRAF1.29191054
43ADRBK21.28149560
44BRSK11.23337817
45NME11.19391758
46CASK1.18685319
47PIM21.12379114
48EPHA21.10247655
49MAP3K41.09568071
50PASK1.04782393
51CSNK1G11.02899663
52MKNK21.02364519
53RPS6KA41.01229400
54CDK81.00996111
55MAP2K71.00720700
56TESK10.97985968
57DYRK20.97338592
58CSNK1G20.94472249
59OXSR10.94093767
60MAP3K80.92202683
61CHEK10.91600126
62EIF2AK20.91478765
63INSRR0.87478660
64MAPKAPK30.85047856
65STK40.84803348
66WNK40.83958391
67MAPK150.81918810
68ERBB30.79612612
69CSNK2A10.77982915
70STK390.76045395
71FGFR20.75658967
72MAPK130.75120929
73IRAK30.74617922
74PLK20.72141713
75PIM10.71688418
76CDK190.71234973
77ATM0.71128134
78CDK40.71117863
79SCYL20.69030161
80PRKCG0.68720037
81STK100.67387310
82CSNK2A20.67311349
83ARAF0.66948429
84BCKDK0.63519054
85AKT30.63276296
86PRKCI0.63156756
87CSNK1A1L0.61277954
88CDK20.60464338
89PAK40.59030822
90MELK0.57826614
91MAP3K110.56365667
92PAK10.55028791
93RPS6KA50.53346569
94PNCK0.51367638
95ABL20.50816127
96MINK10.49906605
97PRKCE0.48588766
98PAK30.48402340
99MUSK0.48291236
100IRAK40.48201963
101STK240.47759878
102CDK10.46979581
103KDR0.46515740
104TIE10.45424021
105BMPR20.44809993
106CSNK1E0.42821985
107CDK30.42705172
108MAPKAPK50.41680807
109TEC0.41662237
110CSNK1A10.40779963
111LIMK10.40403519
112ILK0.38310944
113TGFBR10.38276880
114CAMK2A0.38113496
115MYLK0.37554975
116FGFR10.37060497
117YES10.35738203
118CLK10.35012718
119ADRBK10.34468068
120PINK10.34202459
121PRKACA0.33967751
122MAP3K60.33624946
123PDK40.29430232
124PDK30.29430232
125BCR0.28898061
126STK30.24694380
127NUAK10.24665194
128TAOK20.24397257
129CSNK1G30.23977647
130MAP3K120.23950625
131ERBB40.23638846
132MAP3K30.23252403
133RAF10.21108781
134NLK0.20691923
135FLT30.19727277
136BMPR1B0.18980006
137BRD40.18770919
138LATS20.18769171
139PDK20.18650677
140MAP3K50.18610807

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.76256299
2Mismatch repair_Homo sapiens_hsa034304.09913350
3Proteasome_Homo sapiens_hsa030504.02759453
4Ribosome_Homo sapiens_hsa030103.90549199
5RNA polymerase_Homo sapiens_hsa030203.77517967
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.42991309
7Homologous recombination_Homo sapiens_hsa034403.14653566
8Spliceosome_Homo sapiens_hsa030403.06107448
9Base excision repair_Homo sapiens_hsa034102.93641023
10Nucleotide excision repair_Homo sapiens_hsa034202.82683320
11Pyrimidine metabolism_Homo sapiens_hsa002402.80507394
12RNA transport_Homo sapiens_hsa030132.77951851
13Cell cycle_Homo sapiens_hsa041102.37992862
14Basal transcription factors_Homo sapiens_hsa030222.22757681
15Fanconi anemia pathway_Homo sapiens_hsa034602.22478242
16One carbon pool by folate_Homo sapiens_hsa006702.13411201
17RNA degradation_Homo sapiens_hsa030182.11764179
18Non-homologous end-joining_Homo sapiens_hsa034502.01309425
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.89246346
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.86339404
21Oxidative phosphorylation_Homo sapiens_hsa001901.79069224
22Parkinsons disease_Homo sapiens_hsa050121.73818276
23Protein export_Homo sapiens_hsa030601.67173788
24Huntingtons disease_Homo sapiens_hsa050161.62754087
25Purine metabolism_Homo sapiens_hsa002301.59544723
26Propanoate metabolism_Homo sapiens_hsa006401.38806315
27mRNA surveillance pathway_Homo sapiens_hsa030151.36314268
28p53 signaling pathway_Homo sapiens_hsa041151.35036685
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.30478445
30Caffeine metabolism_Homo sapiens_hsa002321.25844394
31Fatty acid elongation_Homo sapiens_hsa000621.23223063
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.18328472
33Folate biosynthesis_Homo sapiens_hsa007901.10652449
34Butanoate metabolism_Homo sapiens_hsa006501.08074703
35Steroid biosynthesis_Homo sapiens_hsa001001.07908848
36Epstein-Barr virus infection_Homo sapiens_hsa051691.03805015
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.02579767
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.98867933
39Glutathione metabolism_Homo sapiens_hsa004800.97429552
40Maturity onset diabetes of the young_Homo sapiens_hsa049500.96858381
41Alzheimers disease_Homo sapiens_hsa050100.92761721
42Peroxisome_Homo sapiens_hsa041460.87202283
43Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.87161072
44Drug metabolism - other enzymes_Homo sapiens_hsa009830.86594751
45Vitamin B6 metabolism_Homo sapiens_hsa007500.84537128
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.82149155
47Tryptophan metabolism_Homo sapiens_hsa003800.81066942
48Nitrogen metabolism_Homo sapiens_hsa009100.79013882
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.78117825
50Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77807183
51Pentose phosphate pathway_Homo sapiens_hsa000300.74727638
52Sulfur metabolism_Homo sapiens_hsa009200.74721862
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.74666143
54Oocyte meiosis_Homo sapiens_hsa041140.74132853
55Collecting duct acid secretion_Homo sapiens_hsa049660.73764302
56Systemic lupus erythematosus_Homo sapiens_hsa053220.73283295
57Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.72906357
58Pentose and glucuronate interconversions_Homo sapiens_hsa000400.71360161
59Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65833976
60Sulfur relay system_Homo sapiens_hsa041220.65281572
61Cyanoamino acid metabolism_Homo sapiens_hsa004600.64052128
62Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63901397
63Biosynthesis of amino acids_Homo sapiens_hsa012300.63187009
64Nicotine addiction_Homo sapiens_hsa050330.61015108
65Vitamin digestion and absorption_Homo sapiens_hsa049770.60618699
66Arachidonic acid metabolism_Homo sapiens_hsa005900.59737001
67Herpes simplex infection_Homo sapiens_hsa051680.59528725
68Primary bile acid biosynthesis_Homo sapiens_hsa001200.56238298
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.54530330
70Retinol metabolism_Homo sapiens_hsa008300.54351969
71Metabolic pathways_Homo sapiens_hsa011000.52508989
72Selenocompound metabolism_Homo sapiens_hsa004500.52173100
73beta-Alanine metabolism_Homo sapiens_hsa004100.51666283
74Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.50117665
75Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49494332
76Antigen processing and presentation_Homo sapiens_hsa046120.48655555
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46299175
78Viral carcinogenesis_Homo sapiens_hsa052030.45016004
79Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44813394
80Carbon metabolism_Homo sapiens_hsa012000.44766525
81Fructose and mannose metabolism_Homo sapiens_hsa000510.43935144
82Basal cell carcinoma_Homo sapiens_hsa052170.43809330
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43410452
84Linoleic acid metabolism_Homo sapiens_hsa005910.43175186
85Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42534757
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.42182113
87Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.41523467
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40968674
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.40704381
90Legionellosis_Homo sapiens_hsa051340.39200887
91HTLV-I infection_Homo sapiens_hsa051660.35330273
92Galactose metabolism_Homo sapiens_hsa000520.34815197
93Fatty acid degradation_Homo sapiens_hsa000710.33770207
94Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.32830945
95Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.32705597
96Hedgehog signaling pathway_Homo sapiens_hsa043400.31952343
97N-Glycan biosynthesis_Homo sapiens_hsa005100.31199655
98Thyroid cancer_Homo sapiens_hsa052160.30283216
99Olfactory transduction_Homo sapiens_hsa047400.29518548
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28372940
1012-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.28140538
102alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26169756
103Taste transduction_Homo sapiens_hsa047420.25935731
104Cardiac muscle contraction_Homo sapiens_hsa042600.25285784
105Fat digestion and absorption_Homo sapiens_hsa049750.25189178
106Regulation of autophagy_Homo sapiens_hsa041400.23600015
107Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.23496781
108Phenylalanine metabolism_Homo sapiens_hsa003600.23051860
109TGF-beta signaling pathway_Homo sapiens_hsa043500.22789983
110Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.21164351
111Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.21153266
112SNARE interactions in vesicular transport_Homo sapiens_hsa041300.19528731
113Arginine and proline metabolism_Homo sapiens_hsa003300.18711896
114Pyruvate metabolism_Homo sapiens_hsa006200.16003147
115Asthma_Homo sapiens_hsa053100.15860619
116Apoptosis_Homo sapiens_hsa042100.14165029
117Primary immunodeficiency_Homo sapiens_hsa053400.13522760
118Alcoholism_Homo sapiens_hsa050340.12834848
119Graft-versus-host disease_Homo sapiens_hsa053320.12618181
120Phototransduction_Homo sapiens_hsa047440.10689153
121Transcriptional misregulation in cancer_Homo sapiens_hsa052020.09854065
122Intestinal immune network for IgA production_Homo sapiens_hsa046720.09589862
123Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.08896240
124Hippo signaling pathway_Homo sapiens_hsa043900.08644232
125Allograft rejection_Homo sapiens_hsa053300.08004255
126Ether lipid metabolism_Homo sapiens_hsa005650.07858891
127Shigellosis_Homo sapiens_hsa051310.06460423
128Chemical carcinogenesis_Homo sapiens_hsa052040.06433318
129Other glycan degradation_Homo sapiens_hsa005110.06297839
130Hematopoietic cell lineage_Homo sapiens_hsa046400.05769915
131Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.05441068
132Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.04944555
133Tyrosine metabolism_Homo sapiens_hsa003500.04809972
134NOD-like receptor signaling pathway_Homo sapiens_hsa046210.04258878

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »