DPYSL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane assembly (GO:0097105)5.89371928
2neuron cell-cell adhesion (GO:0007158)5.77299962
3presynaptic membrane organization (GO:0097090)5.36453966
4postsynaptic membrane organization (GO:0001941)4.78458655
5vocalization behavior (GO:0071625)4.47833114
6* pyrimidine nucleobase catabolic process (GO:0006208)4.46846642
7limb bud formation (GO:0060174)4.25477252
8cerebral cortex radially oriented cell migration (GO:0021799)4.19120545
9negative regulation of dendrite morphogenesis (GO:0050774)4.16873366
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.06892535
11long-chain fatty acid biosynthetic process (GO:0042759)3.92174654
12regulation of synapse structural plasticity (GO:0051823)3.90061556
13neuron recognition (GO:0008038)3.86052009
14positive regulation of synapse assembly (GO:0051965)3.84026388
15negative regulation of synaptic transmission, GABAergic (GO:0032229)3.83979741
16negative regulation of neurotransmitter transport (GO:0051589)3.81443169
17axon ensheathment in central nervous system (GO:0032291)3.79975792
18central nervous system myelination (GO:0022010)3.79975792
19protein localization to synapse (GO:0035418)3.77087813
20* nucleobase catabolic process (GO:0046113)3.66789495
21sympathetic nervous system development (GO:0048485)3.65494916
22neurotransmitter-gated ion channel clustering (GO:0072578)3.65074669
23regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.64602566
24startle response (GO:0001964)3.64127713
25negative regulation of neurotransmitter secretion (GO:0046929)3.55236597
26negative regulation of dendrite development (GO:2000171)3.54377832
27neuronal action potential propagation (GO:0019227)3.53344978
28cell migration in hindbrain (GO:0021535)3.47574072
29auditory behavior (GO:0031223)3.44419663
30serotonin receptor signaling pathway (GO:0007210)3.42279430
31synaptic vesicle exocytosis (GO:0016079)3.40692137
32retinal ganglion cell axon guidance (GO:0031290)3.38162883
33glycosphingolipid biosynthetic process (GO:0006688)3.31548684
34regulation of glutamate receptor signaling pathway (GO:1900449)3.30452782
35glycerophospholipid catabolic process (GO:0046475)3.26286091
36cerebellar granule cell differentiation (GO:0021707)3.23510268
37dendrite development (GO:0016358)3.21509359
38negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.20672541
39axonal fasciculation (GO:0007413)3.19295023
40positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.18972903
41regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.18125747
42response to pheromone (GO:0019236)3.16419794
43regulation of respiratory system process (GO:0044065)3.15392081
44ionotropic glutamate receptor signaling pathway (GO:0035235)3.12962623
45regulation of synaptic vesicle exocytosis (GO:2000300)3.10073753
46fatty acid elongation (GO:0030497)3.09852314
47synapse assembly (GO:0007416)3.08270326
48establishment of mitochondrion localization (GO:0051654)3.07477352
49glutamate receptor signaling pathway (GO:0007215)3.06354459
50membrane assembly (GO:0071709)3.05786404
51chaperone-mediated protein transport (GO:0072321)3.05557895
52regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.03910300
53regulation of synapse assembly (GO:0051963)3.03847029
54neuron-neuron synaptic transmission (GO:0007270)3.03683431
55positive regulation of dendritic spine morphogenesis (GO:0061003)3.02950201
56regulation of collateral sprouting (GO:0048670)3.02116392
57regulation of pigment cell differentiation (GO:0050932)3.00730264
58regulation of dendritic spine morphogenesis (GO:0061001)2.99897612
59regulation of timing of cell differentiation (GO:0048505)2.98546362
60glial cell proliferation (GO:0014009)2.97289569
61neural tube formation (GO:0001841)2.95933649
62synaptic transmission, glutamatergic (GO:0035249)2.92981463
63negative regulation of translation, ncRNA-mediated (GO:0040033)2.91976818
64regulation of translation, ncRNA-mediated (GO:0045974)2.91976818
65negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.91976818
66synaptic vesicle maturation (GO:0016188)2.91308549
67protein neddylation (GO:0045116)2.90011110
68response to auditory stimulus (GO:0010996)2.89991731
69transmission of nerve impulse (GO:0019226)2.89324895
70protein polyglutamylation (GO:0018095)2.86622976
71central nervous system projection neuron axonogenesis (GO:0021952)2.86166247
72negative regulation of microtubule polymerization (GO:0031115)2.86120963
73mechanosensory behavior (GO:0007638)2.85406621
74positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.82660350
75positive regulation of action potential (GO:0045760)2.80648383
76gamma-aminobutyric acid signaling pathway (GO:0007214)2.80163733
77regulation of dendritic spine development (GO:0060998)2.80005892
78membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.78138138
79hippocampus development (GO:0021766)2.77858638
80regulation of respiratory gaseous exchange (GO:0043576)2.76410704
81regulation of synaptic transmission, GABAergic (GO:0032228)2.76308784
82atrial cardiac muscle cell action potential (GO:0086014)2.73814415
83regulation of development, heterochronic (GO:0040034)2.73330949
84neuron remodeling (GO:0016322)2.72550102
85adult walking behavior (GO:0007628)2.71891728
86negative regulation of execution phase of apoptosis (GO:1900118)2.71851361
87negative regulation of protein localization to cell surface (GO:2000009)2.71359688
88regulation of short-term neuronal synaptic plasticity (GO:0048172)2.70996334
89neuronal action potential (GO:0019228)2.70803023
90regulation of synaptic vesicle transport (GO:1902803)2.69492330
91retina layer formation (GO:0010842)2.68783111
92regulation of axon guidance (GO:1902667)2.68505849
93negative regulation of astrocyte differentiation (GO:0048712)2.67516224
94calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.66389811
95regulation of synaptic transmission, glutamatergic (GO:0051966)2.66376942
96cerebral cortex cell migration (GO:0021795)2.64986901
97regulation of excitatory postsynaptic membrane potential (GO:0060079)2.63853701
98negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.63790922
99negative regulation of axon guidance (GO:1902668)2.63542779
100positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.63431862
101short-term memory (GO:0007614)2.63398122
102proline transport (GO:0015824)2.61452921
103DNA double-strand break processing (GO:0000729)2.60052924
104axon extension (GO:0048675)2.57962582
105hindbrain development (GO:0030902)2.57687009
106negative regulation of axon extension (GO:0030517)2.57254517
107glutamate secretion (GO:0014047)2.56980025
108C4-dicarboxylate transport (GO:0015740)2.56923112
109central nervous system neuron axonogenesis (GO:0021955)2.56287541
110oligodendrocyte differentiation (GO:0048709)2.55938455
111axonogenesis (GO:0007409)2.55789778
112long-term synaptic potentiation (GO:0060291)2.55220622
113retinal cone cell development (GO:0046549)2.54055878
114neurotransmitter uptake (GO:0001504)2.53680515
115urinary tract smooth muscle contraction (GO:0014848)2.52736500
116nonmotile primary cilium assembly (GO:0035058)2.52680087
117negative regulation of axonogenesis (GO:0050771)2.52127368
118regulation of postsynaptic membrane potential (GO:0060078)2.51891115
119behavioral response to nicotine (GO:0035095)2.51654711
120negative regulation of cytosolic calcium ion concentration (GO:0051481)2.51382766
121membrane depolarization during action potential (GO:0086010)2.49187835
122regulation of glycogen (starch) synthase activity (GO:2000465)2.49080224
123somite development (GO:0061053)2.48944328
124adult behavior (GO:0030534)2.48790098
125cochlea development (GO:0090102)2.48645385
126exploration behavior (GO:0035640)2.47142822
127mitochondrion transport along microtubule (GO:0047497)2.47061470
128establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.47061470
129tachykinin receptor signaling pathway (GO:0007217)2.46776022
130dendritic spine morphogenesis (GO:0060997)2.46116169
131regulation of telomere maintenance (GO:0032204)2.45634484
132regulation of neurotransmitter secretion (GO:0046928)2.45529751
133G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.45476728
134dendrite morphogenesis (GO:0048813)2.45149190
135learning (GO:0007612)2.43380595
136protein localization to cilium (GO:0061512)2.42472130
137neurotransmitter secretion (GO:0007269)2.42014278
138developmental pigmentation (GO:0048066)2.41411287
139positive regulation of membrane potential (GO:0045838)2.41312706
140negative regulation of synaptic transmission (GO:0050805)2.40066556
141gamma-aminobutyric acid transport (GO:0015812)2.39100111
142positive regulation of synaptic transmission, GABAergic (GO:0032230)2.39026027
143righting reflex (GO:0060013)2.38075745
144neurofilament cytoskeleton organization (GO:0060052)2.38016401
145inner ear receptor stereocilium organization (GO:0060122)2.37158070

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.92427387
2GBX2_23144817_ChIP-Seq_PC3_Human4.24869380
3TAF15_26573619_Chip-Seq_HEK293_Human2.91584890
4SALL1_21062744_ChIP-ChIP_HESCs_Human2.86445553
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.70207363
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.66357054
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.62658742
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.54931016
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.50554318
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.47118575
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.32241196
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.27639054
13BMI1_23680149_ChIP-Seq_NPCS_Mouse2.26449034
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.23889657
15CBX2_27304074_Chip-Seq_ESCs_Mouse2.23644353
16CTBP2_25329375_ChIP-Seq_LNCAP_Human2.22944934
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.21369079
18JARID2_20075857_ChIP-Seq_MESCs_Mouse2.20349761
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.20197638
20EZH2_18974828_ChIP-Seq_MESCs_Mouse2.16691891
21RNF2_18974828_ChIP-Seq_MESCs_Mouse2.16691891
22POU3F2_20337985_ChIP-ChIP_501MEL_Human2.10824490
23PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.04234874
24P300_19829295_ChIP-Seq_ESCs_Human2.02613378
25* CTBP1_25329375_ChIP-Seq_LNCAP_Human2.01710588
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.91650590
27* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.89151613
28VDR_22108803_ChIP-Seq_LS180_Human1.89039454
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.86831849
30PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.86258710
31RNF2_27304074_Chip-Seq_NSC_Mouse1.85809151
32AR_21572438_ChIP-Seq_LNCaP_Human1.85623649
33REST_21632747_ChIP-Seq_MESCs_Mouse1.85265932
34RNF2_27304074_Chip-Seq_ESCs_Mouse1.82864101
35OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.81985903
36HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.80936374
37EZH2_27294783_Chip-Seq_ESCs_Mouse1.80671182
38MTF2_20144788_ChIP-Seq_MESCs_Mouse1.79565124
39SUZ12_27294783_Chip-Seq_ESCs_Mouse1.78488111
40* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.77645674
41CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.76833621
42IGF1R_20145208_ChIP-Seq_DFB_Human1.72495064
43FUS_26573619_Chip-Seq_HEK293_Human1.71346680
44SMAD4_21799915_ChIP-Seq_A2780_Human1.69131289
45RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.67200433
46TOP2B_26459242_ChIP-Seq_MCF-7_Human1.65537034
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.63038293
48ER_23166858_ChIP-Seq_MCF-7_Human1.58241163
49* SMAD3_21741376_ChIP-Seq_EPCs_Human1.55635246
50CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.54241071
51* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.47572851
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45311066
53RBPJ_22232070_ChIP-Seq_NCS_Mouse1.43448257
54REST_18959480_ChIP-ChIP_MESCs_Mouse1.43257821
55SMAD_19615063_ChIP-ChIP_OVARY_Human1.41509096
56PCGF2_27294783_Chip-Seq_ESCs_Mouse1.38832071
57FLI1_27457419_Chip-Seq_LIVER_Mouse1.38507362
58NANOG_18555785_Chip-Seq_ESCs_Mouse1.37654133
59BCAT_22108803_ChIP-Seq_LS180_Human1.37405742
60TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.36309857
61IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35588180
62CBP_20019798_ChIP-Seq_JUKART_Human1.35588180
63UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32923238
64* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.30517956
65KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.29159103
66EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.27665549
67MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.27576296
68AR_25329375_ChIP-Seq_VCAP_Human1.26810339
69TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26250270
70* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.26109149
71EWS_26573619_Chip-Seq_HEK293_Human1.24911484
72TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24768280
73POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.24768280
74BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.24009158
75STAT3_23295773_ChIP-Seq_U87_Human1.23691368
76CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23212897
77FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.22645118
78* RUNX2_22187159_ChIP-Seq_PCA_Human1.21148496
79PRDM14_20953172_ChIP-Seq_ESCs_Human1.21131352
80TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20472805
81CDX2_19796622_ChIP-Seq_MESCs_Mouse1.19820597
82SUZ12_18555785_Chip-Seq_ESCs_Mouse1.19672230
83E2F1_18555785_Chip-Seq_ESCs_Mouse1.19635155
84AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19145660
85* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.18864697
86P53_22387025_ChIP-Seq_ESCs_Mouse1.18325716
87ARNT_22903824_ChIP-Seq_MCF-7_Human1.18258218
88CMYC_18555785_Chip-Seq_ESCs_Mouse1.16713257
89EZH2_27294783_Chip-Seq_NPCs_Mouse1.15925665
90TCF4_22108803_ChIP-Seq_LS180_Human1.15570267
91TCF4_23295773_ChIP-Seq_U87_Human1.15033611
92AHR_22903824_ChIP-Seq_MCF-7_Human1.13981867
93MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13910788
94ZNF274_21170338_ChIP-Seq_K562_Hela1.12580730
95EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.11722344
96STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.11649012
97* SOX9_26525672_Chip-Seq_HEART_Mouse1.10828910
98KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10684545
99KDM2B_26808549_Chip-Seq_REH_Human1.10333774
100DROSHA_22980978_ChIP-Seq_HELA_Human1.10041001
101* TP53_18474530_ChIP-ChIP_U2OS_Human1.09673657
102FLI1_21867929_ChIP-Seq_TH2_Mouse1.09441812
103JUN_21703547_ChIP-Seq_K562_Human1.09010341
104TAL1_26923725_Chip-Seq_HPCs_Mouse1.08839261
105SOX2_21211035_ChIP-Seq_LN229_Gbm1.08077913
106WT1_19549856_ChIP-ChIP_CCG9911_Human1.07284761
107P300_18555785_Chip-Seq_ESCs_Mouse1.07079274
108SUZ12_27294783_Chip-Seq_NPCs_Mouse1.06439708
109VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.06168740
110STAT3_18555785_Chip-Seq_ESCs_Mouse1.05891303
111PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05570064
112* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03424173
113CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.03343749
114ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.00944204
115NR3C1_23031785_ChIP-Seq_PC12_Mouse0.98759069
116LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98046752
117* RARB_27405468_Chip-Seq_BRAIN_Mouse0.97892530

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.67886097
2MP0001188_hyperpigmentation3.24376362
3MP0004270_analgesia3.13486088
4MP0002735_abnormal_chemical_nociception2.98127658
5MP0006276_abnormal_autonomic_nervous2.91923467
6MP0003635_abnormal_synaptic_transmissio2.57837632
7MP0000778_abnormal_nervous_system2.56378694
8MP0001968_abnormal_touch/_nociception2.51891457
9MP0004859_abnormal_synaptic_plasticity2.49584898
10MP0002734_abnormal_mechanical_nocicepti2.45716693
11MP0001529_abnormal_vocalization2.44643563
12MP0009745_abnormal_behavioral_response2.43580699
13MP0009046_muscle_twitch2.33634469
14MP0002272_abnormal_nervous_system2.33179810
15MP0005423_abnormal_somatic_nervous2.29087772
16MP0002063_abnormal_learning/memory/cond2.29017102
17MP0002064_seizures2.28802023
18MP0002736_abnormal_nociception_after2.27281844
19MP0002572_abnormal_emotion/affect_behav2.25842032
20MP0001486_abnormal_startle_reflex2.17255486
21MP0000569_abnormal_digit_pigmentation2.17036241
22MP0005409_darkened_coat_color2.12046787
23MP0005646_abnormal_pituitary_gland2.11452911
24MP0005171_absent_coat_pigmentation2.10274723
25MP0002184_abnormal_innervation2.05322936
26MP0003787_abnormal_imprinting2.01058714
27MP0005645_abnormal_hypothalamus_physiol1.99409327
28MP0001905_abnormal_dopamine_level1.95807423
29MP0002067_abnormal_sensory_capabilities1.90660972
30MP0001986_abnormal_taste_sensitivity1.87644803
31MP0004742_abnormal_vestibular_system1.83302646
32MP0003136_yellow_coat_color1.81524882
33MP0008877_abnormal_DNA_methylation1.76626842
34MP0001984_abnormal_olfaction1.76170541
35MP0006292_abnormal_olfactory_placode1.73732805
36MP0001970_abnormal_pain_threshold1.73201116
37MP0000015_abnormal_ear_pigmentation1.72182976
38MP0009379_abnormal_foot_pigmentation1.72169503
39MP0002822_catalepsy1.66520760
40MP0002557_abnormal_social/conspecific_i1.62918600
41MP0002733_abnormal_thermal_nociception1.61433773
42MP0006072_abnormal_retinal_apoptosis1.61076615
43MP0004142_abnormal_muscle_tone1.58055962
44MP0002751_abnormal_autonomic_nervous1.55375959
45MP0005386_behavior/neurological_phenoty1.53158595
46MP0004924_abnormal_behavior1.53158595
47MP0001440_abnormal_grooming_behavior1.50459146
48MP0005253_abnormal_eye_physiology1.46216120
49MP0003122_maternal_imprinting1.45231742
50MP0008789_abnormal_olfactory_epithelium1.44153947
51MP0010386_abnormal_urinary_bladder1.41029315
52MP0002882_abnormal_neuron_morphology1.40776791
53MP0002234_abnormal_pharynx_morphology1.39971766
54MP0000631_abnormal_neuroendocrine_gland1.38877620
55MP0005499_abnormal_olfactory_system1.37565561
56MP0005394_taste/olfaction_phenotype1.37565561
57MP0000955_abnormal_spinal_cord1.36062833
58MP0002876_abnormal_thyroid_physiology1.31368514
59MP0005367_renal/urinary_system_phenotyp1.29268471
60MP0000516_abnormal_urinary_system1.29268471
61MP0002102_abnormal_ear_morphology1.26892816
62MP0008569_lethality_at_weaning1.25794183
63MP0000920_abnormal_myelination1.23634134
64MP0004811_abnormal_neuron_physiology1.22585950
65MP0001963_abnormal_hearing_physiology1.22557269
66MP0004133_heterotaxia1.21691720
67MP0000026_abnormal_inner_ear1.21490718
68MP0002752_abnormal_somatic_nervous1.20698894
69MP0003938_abnormal_ear_development1.18211485
70MP0002066_abnormal_motor_capabilities/c1.17326031
71MP0001485_abnormal_pinna_reflex1.17057050
72MP0005187_abnormal_penis_morphology1.13198207
73MP0001501_abnormal_sleep_pattern1.09239765
74MP0008260_abnormal_autophagy1.07752299
75MP0000566_synostosis1.07470782
76MP0002152_abnormal_brain_morphology1.06679780
77MP0004134_abnormal_chest_morphology1.05857185
78MP0004885_abnormal_endolymph1.05367452
79MP0005551_abnormal_eye_electrophysiolog1.05299600
80MP0001502_abnormal_circadian_rhythm1.04224107
81MP0003890_abnormal_embryonic-extraembry1.00257264
82MP0002638_abnormal_pupillary_reflex0.99846838
83MP0003283_abnormal_digestive_organ0.99222464
84MP0002229_neurodegeneration0.98923893
85MP0003634_abnormal_glial_cell0.98339476
86MP0008872_abnormal_physiological_respon0.96877104
87MP0003119_abnormal_digestive_system0.96840317
88MP0004858_abnormal_nervous_system0.95253850
89MP0001177_atelectasis0.92101807
90MP0000049_abnormal_middle_ear0.90594011
91MP0003937_abnormal_limbs/digits/tail_de0.89295590
92MP0000372_irregular_coat_pigmentation0.88798599
93MP0003121_genomic_imprinting0.88547311
94MP0002233_abnormal_nose_morphology0.87955878
95MP0000647_abnormal_sebaceous_gland0.86767185
96MP0002909_abnormal_adrenal_gland0.86567570
97MP0003879_abnormal_hair_cell0.84404523
98MP0003385_abnormal_body_wall0.82781678
99MP0000751_myopathy0.82224907
100MP0005248_abnormal_Harderian_gland0.81584502
101MP0001299_abnormal_eye_distance/0.81453182
102MP0003861_abnormal_nervous_system0.79403235
103MP0002653_abnormal_ependyma_morphology0.78691486
104MP0000427_abnormal_hair_cycle0.78545482
105MP0008058_abnormal_DNA_repair0.78095962
106MP0004085_abnormal_heartbeat0.77892848
107MP0009780_abnormal_chondrocyte_physiolo0.76858309
108MP0009250_abnormal_appendicular_skeleto0.75790429
109MP0003137_abnormal_impulse_conducting0.75012574
110MP0001943_abnormal_respiration0.74734331
111MP0005391_vision/eye_phenotype0.74675873
112MP0002069_abnormal_eating/drinking_beha0.73199985
113MP0000681_abnormal_thyroid_gland0.70809171
114MP0003631_nervous_system_phenotype0.70311992
115MP0004147_increased_porphyrin_level0.70089768
116MP0002177_abnormal_outer_ear0.68673547
117MP0003755_abnormal_palate_morphology0.64804703
118MP0005195_abnormal_posterior_eye0.64357606
119MP0004381_abnormal_hair_follicle0.63385083
120MP0003632_abnormal_nervous_system0.63380671
121MP0002938_white_spotting0.61875885
122MP0002837_dystrophic_cardiac_calcinosis0.60852074
123MP0003329_amyloid_beta_deposits0.59756645
124MP0003633_abnormal_nervous_system0.59053667

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.72019036
2Hyperventilation (HP:0002883)4.38769394
3Atonic seizures (HP:0010819)4.21110725
4Abnormal hair whorl (HP:0010721)4.13058323
5Febrile seizures (HP:0002373)3.89954381
6Hypothermia (HP:0002045)3.71610498
7Epileptic encephalopathy (HP:0200134)3.52563187
8Gait imbalance (HP:0002141)3.33153906
9Degeneration of the lateral corticospinal tracts (HP:0002314)3.32279920
10Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.32279920
11Medial flaring of the eyebrow (HP:0010747)3.20812193
12Nephrogenic diabetes insipidus (HP:0009806)3.06095830
13Congenital primary aphakia (HP:0007707)3.00973705
14Focal seizures (HP:0007359)2.99022326
15Acute necrotizing encephalopathy (HP:0006965)2.95242789
16Myokymia (HP:0002411)2.88297642
17Limb dystonia (HP:0002451)2.86129999
18Genital tract atresia (HP:0001827)2.84709080
19Hemiparesis (HP:0001269)2.82321865
20Vaginal atresia (HP:0000148)2.82004845
21Nephronophthisis (HP:0000090)2.73123747
22Abnormality of midbrain morphology (HP:0002418)2.70870989
23Molar tooth sign on MRI (HP:0002419)2.70870989
24Pheochromocytoma (HP:0002666)2.68619077
25Protruding tongue (HP:0010808)2.68137458
26Progressive macrocephaly (HP:0004481)2.65763516
27Abnormality of the corticospinal tract (HP:0002492)2.63256319
28Broad-based gait (HP:0002136)2.61324832
29Sensory axonal neuropathy (HP:0003390)2.59908898
30Pancreatic cysts (HP:0001737)2.59864092
31Pendular nystagmus (HP:0012043)2.57148332
32Amblyopia (HP:0000646)2.53720407
33Pachygyria (HP:0001302)2.50577679
34Increased serum pyruvate (HP:0003542)2.49211389
35Abnormality of glycolysis (HP:0004366)2.49211389
36Abnormal mitochondria in muscle tissue (HP:0008316)2.48262920
37Progressive inability to walk (HP:0002505)2.47675063
38Progressive cerebellar ataxia (HP:0002073)2.47119102
39Thickened helices (HP:0000391)2.46404329
40Neuroendocrine neoplasm (HP:0100634)2.44280753
41Intestinal atresia (HP:0011100)2.37856728
42Poor coordination (HP:0002370)2.37806372
43Short tibia (HP:0005736)2.36866743
44Volvulus (HP:0002580)2.36060801
45Absent speech (HP:0001344)2.35837281
46Astrocytoma (HP:0009592)2.34601666
47Abnormality of the astrocytes (HP:0100707)2.34601666
48Sleep apnea (HP:0010535)2.33643693
49Retinal dysplasia (HP:0007973)2.33383453
50Optic disc pallor (HP:0000543)2.31746707
51Specific learning disability (HP:0001328)2.30666696
52Aplasia/Hypoplasia of the tibia (HP:0005772)2.30063968
53Hypsarrhythmia (HP:0002521)2.29857911
54Mitochondrial inheritance (HP:0001427)2.29412165
55Amyotrophic lateral sclerosis (HP:0007354)2.28277162
56Esotropia (HP:0000565)2.27570824
57Abnormality of the renal medulla (HP:0100957)2.26359094
58EEG with generalized epileptiform discharges (HP:0011198)2.26264557
59Lissencephaly (HP:0001339)2.25219718
60Megalencephaly (HP:0001355)2.24582601
61Polyphagia (HP:0002591)2.23776888
62Absent/shortened dynein arms (HP:0200106)2.19641794
63Dynein arm defect of respiratory motile cilia (HP:0012255)2.19641794
64Optic nerve hypoplasia (HP:0000609)2.19454669
65Absence seizures (HP:0002121)2.19124873
66Action tremor (HP:0002345)2.18515135
67Fetal akinesia sequence (HP:0001989)2.18010770
68Abnormal ciliary motility (HP:0012262)2.17994273
69Poor suck (HP:0002033)2.17535235
70Oligodactyly (hands) (HP:0001180)2.17312576
71Dialeptic seizures (HP:0011146)2.16030298
72Type II lissencephaly (HP:0007260)2.14954514
73Septo-optic dysplasia (HP:0100842)2.14766953
74Aplasia/Hypoplasia of the lens (HP:0008063)2.12377236
75Parakeratosis (HP:0001036)2.11694336
76Hypoplasia of the brainstem (HP:0002365)2.09978981
77Aplasia/Hypoplasia of the brainstem (HP:0007362)2.09978981
78Hepatoblastoma (HP:0002884)2.09703264
79Acute encephalopathy (HP:0006846)2.06782473
80Glioma (HP:0009733)2.06622431
81Failure to thrive in infancy (HP:0001531)2.06335175
82Akinesia (HP:0002304)2.05976728
83Leukodystrophy (HP:0002415)2.05847626
84Renal hypoplasia (HP:0000089)2.05745041
85Ependymoma (HP:0002888)2.00666979
86Gastroesophageal reflux (HP:0002020)2.00038472
87Narrow nasal bridge (HP:0000446)1.99032863
88Aqueductal stenosis (HP:0002410)1.98591002
89Excessive salivation (HP:0003781)1.98069407
90Drooling (HP:0002307)1.98069407
91Blue irides (HP:0000635)1.97858811
92Postaxial hand polydactyly (HP:0001162)1.97032127
93Methylmalonic acidemia (HP:0002912)1.96117237
94Narrow forehead (HP:0000341)1.94998272
95Inability to walk (HP:0002540)1.94988250
96Termporal pattern (HP:0011008)1.94821233
97Insidious onset (HP:0003587)1.94821233
98Absent septum pellucidum (HP:0001331)1.93922963
99Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.93766728
100Generalized tonic-clonic seizures (HP:0002069)1.93084727
101Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.91663442
102Colon cancer (HP:0003003)1.91606126
1033-Methylglutaconic aciduria (HP:0003535)1.91416165
104Abnormal respiratory epithelium morphology (HP:0012253)1.89949905
105Abnormal respiratory motile cilium morphology (HP:0005938)1.89949905
106Abnormality of the metopic suture (HP:0005556)1.89721887
107Myelomeningocele (HP:0002475)1.89089165
108Abnormality of the septum pellucidum (HP:0007375)1.87781758
109Heterochromia iridis (HP:0001100)1.87725421
110Abnormality of incisor morphology (HP:0011063)1.87597693
111Abnormality of the labia minora (HP:0012880)1.86933843
112Gaze-evoked nystagmus (HP:0000640)1.86692091
113Spastic gait (HP:0002064)1.86139593
114Intellectual disability, moderate (HP:0002342)1.84629862
115Chronic hepatic failure (HP:0100626)1.84448307
116Poor speech (HP:0002465)1.83935590
117Submucous cleft hard palate (HP:0000176)1.83886462
118Exotropia (HP:0000577)1.83624253
119Increased CSF lactate (HP:0002490)1.82675727
120Ulnar claw (HP:0001178)1.82467644
121Impaired social interactions (HP:0000735)1.82090256
122Abnormal social behavior (HP:0012433)1.82090256
123True hermaphroditism (HP:0010459)1.81713896
124Abnormal respiratory motile cilium physiology (HP:0012261)1.81583077
125Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.80155033
126Muscular hypotonia of the trunk (HP:0008936)1.80092212
127Neoplasm of the oral cavity (HP:0100649)1.79880413
128Aplasia/Hypoplasia of the tongue (HP:0010295)1.79864419
129Cupped ear (HP:0000378)1.78850088
130Ankle clonus (HP:0011448)1.77538831
131Pancreatic fibrosis (HP:0100732)1.77056142
132Thyroid-stimulating hormone excess (HP:0002925)1.76415858
133Spastic tetraplegia (HP:0002510)1.75923417
134Scanning speech (HP:0002168)1.75104708
135Split foot (HP:0001839)1.74970995
136Labial hypoplasia (HP:0000066)1.74951169
137Generalized hypotonia (HP:0001290)1.74770205
138Epileptiform EEG discharges (HP:0011182)1.74022767
139Hyperglycinemia (HP:0002154)1.73817820
140Cortical dysplasia (HP:0002539)1.73782451
141Tented upper lip vermilion (HP:0010804)1.73727221
142Scrotal hypoplasia (HP:0000046)1.73521621
143Gastrointestinal atresia (HP:0002589)1.71988957
144Abnormal eating behavior (HP:0100738)1.70824356
145Abnormality of the renal cortex (HP:0011035)1.70701200
146Abnormality of salivation (HP:0100755)1.70079018
147Impaired vibration sensation in the lower limbs (HP:0002166)1.69198767
148Micropenis (HP:0000054)1.68236872
149Polymicrogyria (HP:0002126)1.67589241
150Aplasia/Hypoplasia of the sternum (HP:0006714)1.66146297
151Poor eye contact (HP:0000817)1.65337593
152Aplasia/Hypoplasia of the uvula (HP:0010293)1.64961409
153Widely spaced teeth (HP:0000687)1.64846508
154Abnormality of the lower motor neuron (HP:0002366)1.63377470
155Sclerocornea (HP:0000647)1.62308011
156Neoplasm of the adrenal cortex (HP:0100641)1.61992401

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK7.31960029
2FRK3.36743565
3PRPF4B3.35377581
4MARK13.12692270
5MAP2K72.77276929
6AKT32.70186247
7MAPK132.57097054
8MAP4K22.30860892
9TNIK2.29571706
10SGK2232.02110928
11SGK4942.02110928
12SGK21.96783887
13NTRK31.92874767
14MAP3K41.91020404
15BCR1.89012516
16BMPR1B1.86564549
17TRIM281.83108444
18EPHA41.81956073
19PLK21.80543284
20OXSR11.77485241
21SIK31.70930820
22MAP3K121.68725194
23STK391.54519374
24NTRK21.53275934
25PINK11.47221107
26MINK11.43011771
27UHMK11.36390294
28PKN11.36362083
29CDK191.27458483
30PAK31.24756123
31GRK71.24015546
32ADRBK21.21894655
33MKNK21.20839689
34BMPR21.18549663
35MUSK1.18030303
36LIMK11.09849690
37SGK31.08498089
38ERBB31.08432340
39NUAK11.07059129
40DAPK21.05774818
41CAMK2B1.04471753
42PNCK1.03214280
43STK160.97472007
44EPHB20.94597152
45CAMK2A0.93069250
46BRAF0.91858308
47INSRR0.91780437
48PRKCE0.91341078
49CSNK1G30.90791057
50CCNB10.87957942
51PRKCG0.87163177
52IRAK20.85638544
53MAP2K40.82894660
54GRK50.82313059
55PLK40.81908994
56ACVR1B0.81858686
57CSNK1G20.80986237
58CAMKK20.79488706
59WEE10.78981601
60ADRBK10.78038076
61MKNK10.77915645
62DYRK1A0.76525870
63FES0.74239195
64* CDK50.73770123
65PHKG10.72028919
66PHKG20.72028919
67NME10.71516850
68WNK30.71358240
69CAMK1G0.70405945
70CSNK1A1L0.69382748
71IRAK10.69085029
72NEK60.68695246
73DAPK10.68575351
74RPS6KA20.65987327
75CDK30.64906686
76FGR0.64459811
77MYLK0.63332591
78VRK10.63014231
79CSNK1G10.62479698
80ZAK0.62443405
81PRKCZ0.62324761
82ERBB40.61791490
83BRSK20.61763959
84* DYRK20.57918802
85CAMK2D0.57190867
86DYRK30.55992832
87CDK80.54679630
88CDK180.52891872
89CAMK2G0.50579014
90PRKG10.50489803
91PRKD30.50079534
92CDK140.49986020
93PTK2B0.49337138
94STK110.48483771
95WNK40.48125631
96CAMK10.47929591
97EPHA30.47891311
98PAK60.47645595
99PLK30.46887402
100CSNK1D0.46194146
101EIF2AK20.45261525
102SGK10.44100634
103NTRK10.44058259
104FGFR20.42700852
105PRKCH0.42398200
106CDK150.42079638
107KSR10.41220934
108* PRKACA0.41126801
109CSNK1A10.41054440
110BUB10.40649349
111TGFBR10.40448203
112SRPK10.39991812
113MST40.39344948
114GRK10.39262671
115FER0.36173857
116MAP2K10.35556237
117TSSK60.35486111
118ATM0.34995785
119SIK20.34929686
120RPS6KB10.33780439
121CDK11A0.33753438
122PLK10.33684943
123PRKDC0.33663078
124CSNK1E0.33298565
125MAPK40.32012756
126NEK10.31626910
127MARK20.31616726
128CAMK40.31588079
129WNK10.31267679
130TNK20.30171831
131PRKACB0.29599261
132TIE10.29488609
133PRKCB0.29442032

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.59224042
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.17666942
3Oxidative phosphorylation_Homo sapiens_hsa001902.84253904
4Synaptic vesicle cycle_Homo sapiens_hsa047212.78535413
5Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.75565234
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.59993716
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.51031380
8Collecting duct acid secretion_Homo sapiens_hsa049662.51021409
9Serotonergic synapse_Homo sapiens_hsa047262.40925873
10Taste transduction_Homo sapiens_hsa047422.30139345
11GABAergic synapse_Homo sapiens_hsa047272.16549815
12Morphine addiction_Homo sapiens_hsa050322.13897669
13Phototransduction_Homo sapiens_hsa047442.09418809
14Parkinsons disease_Homo sapiens_hsa050122.09020878
15Glutamatergic synapse_Homo sapiens_hsa047242.03511453
16Olfactory transduction_Homo sapiens_hsa047402.00364657
17Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.96282044
18* Axon guidance_Homo sapiens_hsa043601.94009564
19Alzheimers disease_Homo sapiens_hsa050101.93182249
20Dopaminergic synapse_Homo sapiens_hsa047281.82474690
21Circadian entrainment_Homo sapiens_hsa047131.80662767
22Vibrio cholerae infection_Homo sapiens_hsa051101.77779769
23Non-homologous end-joining_Homo sapiens_hsa034501.71841454
24Steroid biosynthesis_Homo sapiens_hsa001001.68403554
25Fatty acid elongation_Homo sapiens_hsa000621.65927375
26Propanoate metabolism_Homo sapiens_hsa006401.59462185
27Long-term depression_Homo sapiens_hsa047301.56695409
28Amphetamine addiction_Homo sapiens_hsa050311.56680252
29Huntingtons disease_Homo sapiens_hsa050161.54737156
30Long-term potentiation_Homo sapiens_hsa047201.44481345
31Cholinergic synapse_Homo sapiens_hsa047251.43199715
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.40384761
33Maturity onset diabetes of the young_Homo sapiens_hsa049501.40329531
34Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.33652925
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.31362239
36Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.29671301
37Fanconi anemia pathway_Homo sapiens_hsa034601.26225694
38Ether lipid metabolism_Homo sapiens_hsa005651.24979060
39Cocaine addiction_Homo sapiens_hsa050301.24368893
40Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.23810832
41SNARE interactions in vesicular transport_Homo sapiens_hsa041301.19841782
42Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.15691407
43Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.14281877
44Phagosome_Homo sapiens_hsa041451.14015694
45Cardiac muscle contraction_Homo sapiens_hsa042601.12820813
46Calcium signaling pathway_Homo sapiens_hsa040201.12058813
47Insulin secretion_Homo sapiens_hsa049111.11846872
48Renin secretion_Homo sapiens_hsa049241.09825906
49ErbB signaling pathway_Homo sapiens_hsa040121.09781131
50Rheumatoid arthritis_Homo sapiens_hsa053231.08232359
51Salivary secretion_Homo sapiens_hsa049701.00867583
52Protein export_Homo sapiens_hsa030600.99666359
53Gap junction_Homo sapiens_hsa045400.93507431
54Oocyte meiosis_Homo sapiens_hsa041140.92272772
55Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.91530394
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.89554979
57Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.88638393
58Tryptophan metabolism_Homo sapiens_hsa003800.86749125
59Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.83797797
60Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.83472788
61Melanogenesis_Homo sapiens_hsa049160.82443215
62beta-Alanine metabolism_Homo sapiens_hsa004100.81996703
63Nitrogen metabolism_Homo sapiens_hsa009100.79329877
64Gastric acid secretion_Homo sapiens_hsa049710.78600590
65Linoleic acid metabolism_Homo sapiens_hsa005910.77947291
66Oxytocin signaling pathway_Homo sapiens_hsa049210.77849704
67Ras signaling pathway_Homo sapiens_hsa040140.77240439
68Proteasome_Homo sapiens_hsa030500.75073446
69Wnt signaling pathway_Homo sapiens_hsa043100.73671334
70Dorso-ventral axis formation_Homo sapiens_hsa043200.73538129
71Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.71500018
72Circadian rhythm_Homo sapiens_hsa047100.70893638
73Hippo signaling pathway_Homo sapiens_hsa043900.70034123
74Regulation of autophagy_Homo sapiens_hsa041400.69828402
75Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.69207302
76Sphingolipid metabolism_Homo sapiens_hsa006000.68643070
77Hedgehog signaling pathway_Homo sapiens_hsa043400.68540533
78Aldosterone synthesis and secretion_Homo sapiens_hsa049250.67839977
79Autoimmune thyroid disease_Homo sapiens_hsa053200.66354489
80alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.66020659
81cAMP signaling pathway_Homo sapiens_hsa040240.65836831
82RNA degradation_Homo sapiens_hsa030180.65282336
83Fatty acid metabolism_Homo sapiens_hsa012120.65246856
84Melanoma_Homo sapiens_hsa052180.65180783
85Alcoholism_Homo sapiens_hsa050340.63794771
86Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63617937
87Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.63264494
88Vascular smooth muscle contraction_Homo sapiens_hsa042700.63154397
89MAPK signaling pathway_Homo sapiens_hsa040100.61154817
90Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.58838703
91GnRH signaling pathway_Homo sapiens_hsa049120.58495259
92Type II diabetes mellitus_Homo sapiens_hsa049300.54431279
93Butanoate metabolism_Homo sapiens_hsa006500.52414585
94Selenocompound metabolism_Homo sapiens_hsa004500.52010145
95Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.51429964
96Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.51383868
97Estrogen signaling pathway_Homo sapiens_hsa049150.51090456
98Histidine metabolism_Homo sapiens_hsa003400.51014133
99Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50874935
100Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.48952376
101Thyroid hormone synthesis_Homo sapiens_hsa049180.48354248
102Renal cell carcinoma_Homo sapiens_hsa052110.47265007
103Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45959948
104Caffeine metabolism_Homo sapiens_hsa002320.45255323
105Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44028689
106Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.42108068
107Vitamin B6 metabolism_Homo sapiens_hsa007500.41426778
108Homologous recombination_Homo sapiens_hsa034400.40938271
109RNA polymerase_Homo sapiens_hsa030200.40457287
110Phosphatidylinositol signaling system_Homo sapiens_hsa040700.39771960
111Primary bile acid biosynthesis_Homo sapiens_hsa001200.39337662
112Arachidonic acid metabolism_Homo sapiens_hsa005900.38058276
113Ovarian steroidogenesis_Homo sapiens_hsa049130.37064067
114Colorectal cancer_Homo sapiens_hsa052100.36435956
115cGMP-PKG signaling pathway_Homo sapiens_hsa040220.35020606
116Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.34320179
117Rap1 signaling pathway_Homo sapiens_hsa040150.34198266
118Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33753837
119Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.32889152
120Type I diabetes mellitus_Homo sapiens_hsa049400.31252677
121Basal cell carcinoma_Homo sapiens_hsa052170.30827682
122Endometrial cancer_Homo sapiens_hsa052130.30517615
123Dilated cardiomyopathy_Homo sapiens_hsa054140.30401342
124Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30212131
125Sphingolipid signaling pathway_Homo sapiens_hsa040710.28697663
126Tight junction_Homo sapiens_hsa045300.25934962
127Choline metabolism in cancer_Homo sapiens_hsa052310.25372006
128Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.22308179
129Regulation of actin cytoskeleton_Homo sapiens_hsa048100.21907671
130African trypanosomiasis_Homo sapiens_hsa051430.21895676
131Endocytosis_Homo sapiens_hsa041440.21695721
132Basal transcription factors_Homo sapiens_hsa030220.19884103
133Glioma_Homo sapiens_hsa052140.18324257
134Sulfur metabolism_Homo sapiens_hsa009200.18242674
135PI3K-Akt signaling pathway_Homo sapiens_hsa041510.17418865

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