DPYSL4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)5.15531665
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.10272351
3vocalization behavior (GO:0071625)5.08666737
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.99892940
5layer formation in cerebral cortex (GO:0021819)4.94593173
6axonal fasciculation (GO:0007413)4.93142625
7establishment of mitochondrion localization (GO:0051654)4.85296396
8locomotory exploration behavior (GO:0035641)4.80418917
9protein localization to synapse (GO:0035418)4.75709067
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.74029909
11dendritic spine morphogenesis (GO:0060997)4.73301820
12neuron recognition (GO:0008038)4.69508936
13positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.66605388
14cell migration in hindbrain (GO:0021535)4.65376645
15synaptic vesicle exocytosis (GO:0016079)4.60704570
16synaptic vesicle maturation (GO:0016188)4.47205043
17* pyrimidine nucleobase catabolic process (GO:0006208)4.38707971
18regulation of glutamate receptor signaling pathway (GO:1900449)4.36631024
19behavioral response to nicotine (GO:0035095)4.33941806
20ionotropic glutamate receptor signaling pathway (GO:0035235)4.28529779
21central nervous system projection neuron axonogenesis (GO:0021952)4.23331518
22response to pheromone (GO:0019236)4.20882925
23regulation of synaptic vesicle exocytosis (GO:2000300)4.19301899
24mitochondrion transport along microtubule (GO:0047497)4.15910403
25establishment of mitochondrion localization, microtubule-mediated (GO:0034643)4.15910403
26exploration behavior (GO:0035640)4.11313482
27positive regulation of synapse maturation (GO:0090129)4.10828522
28dendrite morphogenesis (GO:0048813)4.02269440
29glutamate secretion (GO:0014047)3.95061338
30glutamate receptor signaling pathway (GO:0007215)3.93805234
31synaptic vesicle docking involved in exocytosis (GO:0016081)3.92296145
32regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.90927784
33cerebellar granule cell differentiation (GO:0021707)3.87350876
34negative regulation of microtubule polymerization (GO:0031115)3.86216969
35synaptic transmission, glutamatergic (GO:0035249)3.85947123
36cerebellar Purkinje cell differentiation (GO:0021702)3.83837350
37neurotransmitter secretion (GO:0007269)3.77781418
38regulation of synapse structural plasticity (GO:0051823)3.76807912
39postsynaptic membrane organization (GO:0001941)3.73105970
40positive regulation of synapse assembly (GO:0051965)3.64721209
41regulation of synaptic vesicle transport (GO:1902803)3.60840109
42regulation of neuronal synaptic plasticity (GO:0048168)3.60440204
43neuron-neuron synaptic transmission (GO:0007270)3.51402671
44neurotransmitter-gated ion channel clustering (GO:0072578)3.47817023
45neuronal action potential propagation (GO:0019227)3.47609398
46regulation of long-term neuronal synaptic plasticity (GO:0048169)3.43446077
47gamma-aminobutyric acid transport (GO:0015812)3.38302601
48regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.37913540
49G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.36778175
50axon extension involved in axon guidance (GO:0048846)3.35751315
51neuron projection extension involved in neuron projection guidance (GO:1902284)3.35751315
52positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.35005034
53auditory behavior (GO:0031223)3.34149773
54cerebral cortex radially oriented cell migration (GO:0021799)3.32871031
55substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.32274142
56substrate-independent telencephalic tangential migration (GO:0021826)3.32274142
57transmission of nerve impulse (GO:0019226)3.30674876
58establishment of nucleus localization (GO:0040023)3.30410093
59retinal ganglion cell axon guidance (GO:0031290)3.29100989
60regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.28396207
61cell differentiation in hindbrain (GO:0021533)3.28092894
62presynaptic membrane organization (GO:0097090)3.27140075
63spinal cord development (GO:0021510)3.26766694
64cerebellum development (GO:0021549)3.25511867
65regulation of synapse maturation (GO:0090128)3.24871956
66* nucleobase catabolic process (GO:0046113)3.24132138
67central nervous system neuron axonogenesis (GO:0021955)3.24086144
68positive regulation of dendritic spine morphogenesis (GO:0061003)3.22100538
69synaptic vesicle endocytosis (GO:0048488)3.17664375
70neuromuscular synaptic transmission (GO:0007274)3.16977524
71spinal cord association neuron differentiation (GO:0021527)3.16161358
72synapse assembly (GO:0007416)3.15147609
73regulation of excitatory postsynaptic membrane potential (GO:0060079)3.15122463
74innervation (GO:0060384)3.14626508
75presynaptic membrane assembly (GO:0097105)3.14548055
76calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.14320448
77positive regulation of membrane potential (GO:0045838)3.12194391
78regulation of postsynaptic membrane potential (GO:0060078)3.12086588
79hippocampus development (GO:0021766)3.12026313
80long-term memory (GO:0007616)3.10369792
81mating behavior (GO:0007617)3.09656331
82regulation of dendritic spine morphogenesis (GO:0061001)3.08455825
83neuronal ion channel clustering (GO:0045161)3.07876006
84forebrain neuron differentiation (GO:0021879)3.06025136
85negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.04747572
86ganglion development (GO:0061548)3.04359361
87regulation of synapse assembly (GO:0051963)3.04289690
88cell communication by electrical coupling (GO:0010644)3.03727082
89neuron projection extension (GO:1990138)3.01486137
90dendritic spine organization (GO:0097061)3.01311195
91regulation of respiratory system process (GO:0044065)3.01298577
92membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.00844160
93positive regulation of dendritic spine development (GO:0060999)3.00546469
94regulation of respiratory gaseous exchange (GO:0043576)3.00430005
95short-term memory (GO:0007614)2.99455566
96synapse organization (GO:0050808)2.98155079
97regulation of synapse organization (GO:0050807)2.96539079
98mechanosensory behavior (GO:0007638)2.96512636
99membrane hyperpolarization (GO:0060081)2.96495085
100axon extension (GO:0048675)2.95857668
101neurotransmitter transport (GO:0006836)2.94951046
102neurofilament cytoskeleton organization (GO:0060052)2.94627559
103negative regulation of axon extension (GO:0030517)2.94094095
104regulation of neurotransmitter secretion (GO:0046928)2.93374920
105neuromuscular process controlling balance (GO:0050885)2.90640216
106regulation of vesicle fusion (GO:0031338)2.90570689
107adult walking behavior (GO:0007628)2.89657589
108adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.89267873
109dopaminergic neuron differentiation (GO:0071542)2.87382951
110cerebellar Purkinje cell layer development (GO:0021680)2.87109055
111olfactory bulb development (GO:0021772)2.86412556
112regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.85173105
113response to auditory stimulus (GO:0010996)2.84720233
114negative regulation of axon guidance (GO:1902668)2.83830730
115regulation of synaptic transmission, glutamatergic (GO:0051966)2.83749507
116behavioral defense response (GO:0002209)2.81957089
117behavioral fear response (GO:0001662)2.81957089
118dendrite development (GO:0016358)2.81895048
119neuron migration (GO:0001764)2.79501048
120negative regulation of axonogenesis (GO:0050771)2.79123275
121gamma-aminobutyric acid signaling pathway (GO:0007214)2.77681802
122nonmotile primary cilium assembly (GO:0035058)2.76606183
123negative regulation of synaptic transmission, GABAergic (GO:0032229)2.75678231
124learning (GO:0007612)2.75171806
125regulation of axon guidance (GO:1902667)2.75051625
126positive regulation of synaptic transmission, GABAergic (GO:0032230)2.74710239
127positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.67794506
128camera-type eye morphogenesis (GO:0048593)2.67055157
129synaptic transmission, cholinergic (GO:0007271)2.65695594
130behavioral response to ethanol (GO:0048149)2.59659923
131neuronal stem cell maintenance (GO:0097150)2.55906834
132ephrin receptor signaling pathway (GO:0048013)2.55785394
133regulation of axon extension involved in axon guidance (GO:0048841)2.52900275

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.36943820
2JARID2_20064375_ChIP-Seq_MESCs_Mouse3.29229568
3GBX2_23144817_ChIP-Seq_PC3_Human3.08311442
4EZH2_27304074_Chip-Seq_ESCs_Mouse3.05522869
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.05227869
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.01547505
7* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.91628995
8* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.91628995
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.85645863
10NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.79307069
11* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.69165062
12CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.63416802
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.62248336
14EZH2_27294783_Chip-Seq_ESCs_Mouse2.60539591
15* REST_21632747_ChIP-Seq_MESCs_Mouse2.59985870
16* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.56625436
17TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.53395731
18SUZ12_27294783_Chip-Seq_ESCs_Mouse2.51956061
19* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.50891820
20RNF2_27304074_Chip-Seq_ESCs_Mouse2.48742717
21* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.34830731
22* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.31732093
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.27519003
24DROSHA_22980978_ChIP-Seq_HELA_Human2.26710749
25* REST_18959480_ChIP-ChIP_MESCs_Mouse2.19321851
26EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.16955123
27CBX2_27304074_Chip-Seq_ESCs_Mouse2.07195830
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.03305746
29* RARB_27405468_Chip-Seq_BRAIN_Mouse2.01268890
30IKZF1_21737484_ChIP-ChIP_HCT116_Human1.99579496
31PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.98653372
32AR_21572438_ChIP-Seq_LNCaP_Human1.87809430
33ERG_21242973_ChIP-ChIP_JURKAT_Human1.84162971
34MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.84148125
35ZNF274_21170338_ChIP-Seq_K562_Hela1.82380805
36BMI1_23680149_ChIP-Seq_NPCS_Mouse1.77140846
37RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.74390543
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.73772318
39RING1B_27294783_Chip-Seq_ESCs_Mouse1.67157608
40RNF2_27304074_Chip-Seq_NSC_Mouse1.60668023
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.57828022
42RING1B_27294783_Chip-Seq_NPCs_Mouse1.56823938
43ZFP281_18757296_ChIP-ChIP_E14_Mouse1.53445045
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49972286
45STAT6_21828071_ChIP-Seq_BEAS2B_Human1.47427783
46OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.40770722
47TAF15_26573619_Chip-Seq_HEK293_Human1.40437134
48IGF1R_20145208_ChIP-Seq_DFB_Human1.35432985
49WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.29217672
50EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.28495697
51TP53_20018659_ChIP-ChIP_R1E_Mouse1.26129685
52RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.25742839
53HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.25733647
54ZFP57_27257070_Chip-Seq_ESCs_Mouse1.23589456
55* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.22623709
56SMAD4_21799915_ChIP-Seq_A2780_Human1.18829013
57AR_19668381_ChIP-Seq_PC3_Human1.16932967
58SMAD3_21741376_ChIP-Seq_EPCs_Human1.16376838
59SOX2_21211035_ChIP-Seq_LN229_Gbm1.14870344
60KDM2B_26808549_Chip-Seq_K562_Human1.14843859
61SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14489205
62DNAJC2_21179169_ChIP-ChIP_NT2_Human1.14113794
63TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11782959
64POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11782959
65TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.11202046
66TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11073508
67P300_19829295_ChIP-Seq_ESCs_Human1.10107865
68* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.07868649
69ZFP281_27345836_Chip-Seq_ESCs_Mouse1.06365925
70P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03094155
71YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02549644
72KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.02514267
73POU5F1_16153702_ChIP-ChIP_HESCs_Human1.02406606
74TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01959866
75TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01938445
76RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.01657298
77WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01057350
78OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00450967
79* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.99846366
80SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99760501
81ARNT_22903824_ChIP-Seq_MCF-7_Human0.98724012
82MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98723549
83NR3C1_23031785_ChIP-Seq_PC12_Mouse0.98500050
84SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.97175631
85PIAS1_25552417_ChIP-Seq_VCAP_Human0.95047048
86FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.94492537
87AR_25329375_ChIP-Seq_VCAP_Human0.93795157
88CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.92558995
89* SMAD3_21741376_ChIP-Seq_ESCs_Human0.91803427
90AHR_22903824_ChIP-Seq_MCF-7_Human0.91004215
91SMAD4_21741376_ChIP-Seq_HESCs_Human0.90442098
92CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89691869
93GATA1_26923725_Chip-Seq_HPCs_Mouse0.88433410
94TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87448419
95STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.87369358
96STAT3_23295773_ChIP-Seq_U87_Human0.87303007
97DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.87099925
98CTCF_27219007_Chip-Seq_Bcells_Human0.86820846
99RUNX2_22187159_ChIP-Seq_PCA_Human0.86475200
100ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.86437958
101CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.85338772
102SOX9_26525672_Chip-Seq_HEART_Mouse0.84285639
103POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.82188203
104IRF1_19129219_ChIP-ChIP_H3396_Human0.82121972
105CDX2_19796622_ChIP-Seq_MESCs_Mouse0.81825446
106* SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.81795921
107* SOX2_18555785_ChIP-Seq_MESCs_Mouse0.81650245
108RBPJ_22232070_ChIP-Seq_NCS_Mouse0.81039149
109VDR_22108803_ChIP-Seq_LS180_Human0.80827749
110SOX2_16153702_ChIP-ChIP_HESCs_Human0.80134496
111ISL1_27105846_Chip-Seq_CPCs_Mouse0.78711440
112CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.78478296
113SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.78175067
114RUNX1_26923725_Chip-Seq_HPCs_Mouse0.77545651
115LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77401811

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0004859_abnormal_synaptic_plasticity4.60237729
2MP0003880_abnormal_central_pattern4.04388668
3* MP0003635_abnormal_synaptic_transmissio3.39316426
4MP0004270_analgesia3.04272343
5MP0000778_abnormal_nervous_system3.03285030
6MP0005423_abnormal_somatic_nervous3.01453574
7MP0002063_abnormal_learning/memory/cond2.87467127
8MP0009046_muscle_twitch2.65546812
9MP0009745_abnormal_behavioral_response2.59121370
10MP0006276_abnormal_autonomic_nervous2.54711678
11MP0002653_abnormal_ependyma_morphology2.52880391
12MP0002184_abnormal_innervation2.51910110
13MP0002064_seizures2.51537791
14MP0002572_abnormal_emotion/affect_behav2.34304262
15MP0002734_abnormal_mechanical_nocicepti2.30893644
16MP0001486_abnormal_startle_reflex2.25267094
17MP0001968_abnormal_touch/_nociception2.21081919
18MP0002272_abnormal_nervous_system2.05754366
19MP0001440_abnormal_grooming_behavior1.93797829
20MP0002557_abnormal_social/conspecific_i1.93125880
21MP0002067_abnormal_sensory_capabilities1.92355089
22MP0000955_abnormal_spinal_cord1.90050694
23MP0002735_abnormal_chemical_nociception1.87041553
24MP0002733_abnormal_thermal_nociception1.83225396
25MP0004811_abnormal_neuron_physiology1.81601343
26* MP0002882_abnormal_neuron_morphology1.71535574
27MP0002736_abnormal_nociception_after1.66610027
28MP0003122_maternal_imprinting1.63955058
29MP0003123_paternal_imprinting1.61919668
30MP0005394_taste/olfaction_phenotype1.59536174
31MP0005499_abnormal_olfactory_system1.59536174
32MP0004858_abnormal_nervous_system1.57802055
33MP0004742_abnormal_vestibular_system1.57573408
34MP0001970_abnormal_pain_threshold1.56552911
35MP0000569_abnormal_digit_pigmentation1.55978975
36MP0008569_lethality_at_weaning1.55870361
37MP0001984_abnormal_olfaction1.52523669
38MP0005386_behavior/neurological_phenoty1.51295507
39MP0004924_abnormal_behavior1.51295507
40MP0004885_abnormal_endolymph1.50722950
41MP0004133_heterotaxia1.49082388
42* MP0002152_abnormal_brain_morphology1.48944525
43MP0002066_abnormal_motor_capabilities/c1.38164390
44MP0003861_abnormal_nervous_system1.36461969
45MP0008789_abnormal_olfactory_epithelium1.36126537
46MP0000631_abnormal_neuroendocrine_gland1.32831972
47MP0001529_abnormal_vocalization1.32295500
48MP0002752_abnormal_somatic_nervous1.31814926
49MP0001501_abnormal_sleep_pattern1.31389430
50MP0003787_abnormal_imprinting1.30920007
51MP0005645_abnormal_hypothalamus_physiol1.29960533
52MP0002102_abnormal_ear_morphology1.29335838
53MP0006072_abnormal_retinal_apoptosis1.26159505
54MP0003938_abnormal_ear_development1.26085410
55MP0005551_abnormal_eye_electrophysiolog1.26032962
56MP0004142_abnormal_muscle_tone1.24692154
57MP0010030_abnormal_orbit_morphology1.23064152
58MP0003329_amyloid_beta_deposits1.22053370
59MP0002751_abnormal_autonomic_nervous1.21921528
60MP0001293_anophthalmia1.20210183
61MP0000566_synostosis1.20162636
62MP0009379_abnormal_foot_pigmentation1.19107105
63MP0003879_abnormal_hair_cell1.17457859
64MP0004145_abnormal_muscle_electrophysio1.17057786
65MP0005187_abnormal_penis_morphology1.16323978
66MP0009780_abnormal_chondrocyte_physiolo1.14390802
67MP0002909_abnormal_adrenal_gland1.14255313
68MP0006292_abnormal_olfactory_placode1.13759442
69MP0005646_abnormal_pituitary_gland1.13503843
70MP0001502_abnormal_circadian_rhythm1.12982074
71MP0000537_abnormal_urethra_morphology1.10427094
72MP0001905_abnormal_dopamine_level1.09881370
73MP0002233_abnormal_nose_morphology1.07560569
74MP0000026_abnormal_inner_ear1.06446160
75MP0000751_myopathy1.05538085
76MP0002638_abnormal_pupillary_reflex1.01014697
77MP0003119_abnormal_digestive_system1.00479156
78MP0008961_abnormal_basal_metabolism1.00143614
79MP0001963_abnormal_hearing_physiology0.98617392
80MP0003136_yellow_coat_color0.96035900
81MP0005253_abnormal_eye_physiology0.94898440
82MP0000049_abnormal_middle_ear0.93964853
83MP0008995_early_reproductive_senescence0.93667686
84MP0003137_abnormal_impulse_conducting0.93559687
85MP0002822_catalepsy0.93248245
86MP0002069_abnormal_eating/drinking_beha0.91900943
87MP0002249_abnormal_larynx_morphology0.90044294
88MP0008877_abnormal_DNA_methylation0.88938064
89MP0002697_abnormal_eye_size0.88815255
90MP0001299_abnormal_eye_distance/0.87861152
91MP0003755_abnormal_palate_morphology0.87783841
92MP0003634_abnormal_glial_cell0.87250376
93MP0002229_neurodegeneration0.86782371
94MP0003121_genomic_imprinting0.86257358
95MP0003890_abnormal_embryonic-extraembry0.85544817
96MP0002938_white_spotting0.85074420
97MP0003942_abnormal_urinary_system0.84335010
98MP0003385_abnormal_body_wall0.84221422
99MP0003315_abnormal_perineum_morphology0.83499461
100MP0003283_abnormal_digestive_organ0.83023346
101MP0003937_abnormal_limbs/digits/tail_de0.82523363
102MP0001286_abnormal_eye_development0.81476618
103MP0002116_abnormal_craniofacial_bone0.81103325
104MP0000534_abnormal_ureter_morphology0.81081040
105MP0003632_abnormal_nervous_system0.81046667
106MP0005391_vision/eye_phenotype0.80950423
107MP0002234_abnormal_pharynx_morphology0.79862431
108MP0001188_hyperpigmentation0.78596358
109MP0005195_abnormal_posterior_eye0.78162956
110MP0001485_abnormal_pinna_reflex0.77733868
111MP0002081_perinatal_lethality0.76184443
112MP0001943_abnormal_respiration0.73619401
113MP0004085_abnormal_heartbeat0.72281084
114MP0003631_nervous_system_phenotype0.70514883
115MP0002082_postnatal_lethality0.70100601
116MP0010770_preweaning_lethality0.70100601
117MP0010769_abnormal_survival0.69743527

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)4.79200778
2Focal motor seizures (HP:0011153)4.67614044
3Focal seizures (HP:0007359)4.24746023
4Progressive cerebellar ataxia (HP:0002073)3.98788415
5Visual hallucinations (HP:0002367)3.70098152
6Epileptic encephalopathy (HP:0200134)3.58893727
7Broad-based gait (HP:0002136)3.25929127
8Action tremor (HP:0002345)3.11969609
9Amblyopia (HP:0000646)3.06737715
10Ankle clonus (HP:0011448)3.05212411
11Febrile seizures (HP:0002373)2.99622769
12Atonic seizures (HP:0010819)2.97797975
13Supranuclear gaze palsy (HP:0000605)2.92730907
14Limb dystonia (HP:0002451)2.88633463
15Septo-optic dysplasia (HP:0100842)2.80148167
16Rib fusion (HP:0000902)2.70569891
17Hypoplasia of the brainstem (HP:0002365)2.67321520
18Aplasia/Hypoplasia of the brainstem (HP:0007362)2.67321520
19Mutism (HP:0002300)2.66340465
20Gait imbalance (HP:0002141)2.64503184
21Amyotrophic lateral sclerosis (HP:0007354)2.64476013
22Excessive salivation (HP:0003781)2.63654732
23Drooling (HP:0002307)2.63654732
24Absence seizures (HP:0002121)2.61516329
25Polyphagia (HP:0002591)2.54606119
26Gaze-evoked nystagmus (HP:0000640)2.49120890
27Hemiparesis (HP:0001269)2.48180900
28Abnormality of the lower motor neuron (HP:0002366)2.47520485
29Short 4th metacarpal (HP:0010044)2.44826131
30Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.44826131
31Truncal ataxia (HP:0002078)2.44552406
32Abnormal eating behavior (HP:0100738)2.44257044
33Generalized tonic-clonic seizures (HP:0002069)2.41546565
34Hyperventilation (HP:0002883)2.40774637
35Genetic anticipation (HP:0003743)2.40644675
36Abnormality of the corticospinal tract (HP:0002492)2.36437204
37High anterior hairline (HP:0009890)2.36144144
38Dialeptic seizures (HP:0011146)2.35741828
39Agitation (HP:0000713)2.35545091
40Lissencephaly (HP:0001339)2.31071036
41Depression (HP:0000716)2.30110832
42Failure to thrive in infancy (HP:0001531)2.27221129
43Dysdiadochokinesis (HP:0002075)2.26242505
44Insomnia (HP:0100785)2.24826397
45Exotropia (HP:0000577)2.22171359
46Poor eye contact (HP:0000817)2.21208119
47Megalencephaly (HP:0001355)2.20878585
48Abnormality of the 4th metacarpal (HP:0010012)2.20206922
49Shoulder girdle muscle weakness (HP:0003547)2.18431290
50Optic nerve hypoplasia (HP:0000609)2.16993625
51Impaired vibration sensation in the lower limbs (HP:0002166)2.16847018
52Retinal dysplasia (HP:0007973)2.14791122
53Spastic gait (HP:0002064)2.14686385
54Pheochromocytoma (HP:0002666)2.13678251
55Aqueductal stenosis (HP:0002410)2.13602031
56Pachygyria (HP:0001302)2.12897214
57Esotropia (HP:0000565)2.12167641
58Vitreoretinal degeneration (HP:0000655)2.12020141
59Urinary urgency (HP:0000012)2.09809297
60Cutaneous finger syndactyly (HP:0010554)2.08519346
61Specific learning disability (HP:0001328)2.07253626
62Hypoventilation (HP:0002791)2.06272808
63Progressive inability to walk (HP:0002505)2.05135767
64Absent speech (HP:0001344)2.04980593
65Spastic tetraplegia (HP:0002510)2.03921606
66Urinary bladder sphincter dysfunction (HP:0002839)2.03911687
67Neoplasm of the heart (HP:0100544)2.03780066
68Epileptiform EEG discharges (HP:0011182)2.03327453
69Congenital primary aphakia (HP:0007707)2.02977615
70EEG with generalized epileptiform discharges (HP:0011198)2.02481651
71Turricephaly (HP:0000262)2.02037038
72Pointed chin (HP:0000307)2.01732721
73Impaired social interactions (HP:0000735)2.01337127
74Abnormal social behavior (HP:0012433)2.01337127
75Cutaneous syndactyly (HP:0012725)2.00350025
76Hyperacusis (HP:0010780)1.99705391
77Hypsarrhythmia (HP:0002521)1.99128160
78Oligodactyly (HP:0012165)1.98991344
79Generalized hypotonia (HP:0001290)1.98690157
80Fetal akinesia sequence (HP:0001989)1.98558280
81Impaired smooth pursuit (HP:0007772)1.96962992
82Abnormality of the aortic arch (HP:0012303)1.96933741
83Medial flaring of the eyebrow (HP:0010747)1.95964100
84Abnormality of the intervertebral disk (HP:0005108)1.95311835
85Elfin facies (HP:0004428)1.94656598
86Nephrogenic diabetes insipidus (HP:0009806)1.94558129
87Vaginal atresia (HP:0000148)1.94393618
88Nephronophthisis (HP:0000090)1.93477399
89Trigonocephaly (HP:0000243)1.93202670
90Termporal pattern (HP:0011008)1.92552678
91Insidious onset (HP:0003587)1.92552678
92Shawl scrotum (HP:0000049)1.91878546
93Anxiety (HP:0000739)1.91004308
94Cortical dysplasia (HP:0002539)1.90284217
95Absent septum pellucidum (HP:0001331)1.89745123
96Intestinal atresia (HP:0011100)1.88799906
97Dysmetria (HP:0001310)1.87557102
98Genital tract atresia (HP:0001827)1.87129027
99Renal dysplasia (HP:0000110)1.86794540
100Abnormality of ocular smooth pursuit (HP:0000617)1.86094712
101Narrow nasal bridge (HP:0000446)1.85818585
102Oligodactyly (hands) (HP:0001180)1.85570905
103Poor suck (HP:0002033)1.83530288
104Morphological abnormality of the pyramidal tract (HP:0002062)1.82903818
105Renal duplication (HP:0000075)1.82574161
106Abnormality of the labia minora (HP:0012880)1.80888782
107Polymicrogyria (HP:0002126)1.80857254
108Autism (HP:0000717)1.78902582
109Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.78259839
110Overriding aorta (HP:0002623)1.77335007
111Growth hormone deficiency (HP:0000824)1.77016518
112Sporadic (HP:0003745)1.76922241
113Renal hypoplasia (HP:0000089)1.75730641
114Stereotypic behavior (HP:0000733)1.75215012
115Akinesia (HP:0002304)1.75063597
116Lower limb muscle weakness (HP:0007340)1.75056979
117Meningocele (HP:0002435)1.74811272
118Sleep apnea (HP:0010535)1.74318677
119Labial hypoplasia (HP:0000066)1.74211383
120Hepatoblastoma (HP:0002884)1.74025866
121Torticollis (HP:0000473)1.73342791
122Anophthalmia (HP:0000528)1.73162604
123Neuroendocrine neoplasm (HP:0100634)1.72836051
124Hemiplegia (HP:0002301)1.71909083
125Hypoplasia of the corpus callosum (HP:0002079)1.70919116
126Apathy (HP:0000741)1.69825682
127Type II lissencephaly (HP:0007260)1.68168999
128Protruding tongue (HP:0010808)1.67994898
129Sacral dimple (HP:0000960)1.67976006
130Anosmia (HP:0000458)1.67840621
131Abnormality of the diencephalon (HP:0010662)1.67492083
132Scanning speech (HP:0002168)1.67352516
133Micropenis (HP:0000054)1.67105140
134Cerebral inclusion bodies (HP:0100314)1.66006954
135Inappropriate behavior (HP:0000719)1.65792613
136Renovascular hypertension (HP:0100817)1.65164220
137Intention tremor (HP:0002080)1.63910843
138Anomalous pulmonary venous return (HP:0010772)1.63896771
139Narrow forehead (HP:0000341)1.62327001
140Hemivertebrae (HP:0002937)1.61976997
141Abnormality of the pulmonary veins (HP:0011718)1.60707560
142Optic nerve coloboma (HP:0000588)1.60321844
143Morphological abnormality of the middle ear (HP:0008609)1.58427154
144Intellectual disability, moderate (HP:0002342)1.58044579
145Poor coordination (HP:0002370)1.55668466
146Abnormality of midbrain morphology (HP:0002418)1.54844284
147Molar tooth sign on MRI (HP:0002419)1.54844284

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.33603301
2NTRK33.18831922
3NTRK22.85785926
4MAP3K92.83009492
5MAP3K42.70135416
6MINK12.57081408
7CDK192.48533711
8KSR12.40039983
9EPHA42.32184290
10CASK2.24749905
11TYRO32.20355477
12PAK62.19146676
13MAP2K72.14046577
14MAPK132.12662797
15DAPK21.90824293
16TNIK1.90157731
17DYRK21.71834108
18UHMK11.70242125
19EPHB21.60184270
20SIK21.51634505
21PRPF4B1.47086093
22FGFR21.46349833
23MAP2K41.46269094
24PHKG11.41225058
25PHKG21.41225058
26ERBB31.36413614
27PNCK1.36195034
28BCR1.34518439
29CDK51.34318794
30SIK31.33109931
31MAP3K121.26202993
32PAK31.23660975
33PINK11.20981760
34LIMK11.20531444
35IRAK21.15744369
36ICK1.15017808
37DYRK31.10995335
38MAP4K21.10385823
39PRKCG1.10068520
40DAPK11.09273420
41DYRK1A1.06077278
42CAMKK11.03181410
43CDK181.02761197
44PLK20.97684970
45CDK150.95164585
46NTRK10.95089002
47CSNK1G20.94390721
48CDK140.92225959
49CAMK1D0.91895390
50CDK11A0.89417898
51LATS20.85165559
52SGK2230.82918118
53SGK4940.82918118
54KSR20.82156448
55EPHA30.81626335
56PRKD30.77911072
57GRK50.77137323
58WNK30.75447595
59PRKCZ0.74932810
60MARK20.74093855
61CSNK1G30.72468237
62PKN10.72416653
63ERBB20.72378518
64PRKCH0.70626916
65WNK40.67894826
66STK110.66507619
67PDGFRA0.66256464
68CAMK2A0.65551947
69DDR20.65524028
70RET0.62752020
71NEK60.62214078
72CSNK1A1L0.61869767
73RPS6KA20.60140948
74FES0.58419350
75TRIM280.58320154
76ROCK20.57899577
77FGFR10.56059505
78CDC42BPA0.54468916
79PRKAA10.53068314
80TLK10.52722144
81CAMK2B0.51293301
82OXSR10.51014412
83BRD40.49047401
84CAMK1G0.48739788
85STK380.47475846
86MAP3K110.47181423
87CAMK10.46947408
88BMPR1B0.46656613
89BRSK10.46067015
90FER0.44709659
91MAP3K100.44700553
92SGK10.44008789
93ROCK10.43664591
94CSNK1G10.43603260
95ALK0.43515703
96FYN0.42940485
97TIE10.42594445
98MAPK90.42072523
99DYRK1B0.41886470
100LMTK20.41866650
101MAPK150.41822535
102BCKDK0.40679591
103CAMK40.40245318
104ADRBK10.40239665
105NME10.39949530
106CAMKK20.39817938
107FGR0.38270362
108RPS6KA30.37824434
109AURKA0.37644083
110MKNK10.37530719
111CSNK1D0.36736235
112PRKDC0.36134906
113PRKACA0.35479404
114CCNB10.35167237
115CSNK1E0.34879177
116SGK20.34427467
117PRKCE0.34326582
118MKNK20.34226728
119WNK10.34172629
120DMPK0.34034036
121TAOK20.31949550
122CSNK1A10.31861264
123TESK10.31799300
124GSK3B0.31251923
125ARAF0.29465912
126MAPK80.27909946
127SGK30.27196458

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.73440328
2Synaptic vesicle cycle_Homo sapiens_hsa047213.06636370
3GABAergic synapse_Homo sapiens_hsa047272.57617873
4Glutamatergic synapse_Homo sapiens_hsa047242.57508000
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.53273949
6Circadian entrainment_Homo sapiens_hsa047132.45449526
7Axon guidance_Homo sapiens_hsa043602.32764307
8Long-term potentiation_Homo sapiens_hsa047202.21549843
9Morphine addiction_Homo sapiens_hsa050322.20350043
10Dopaminergic synapse_Homo sapiens_hsa047282.12657571
11Olfactory transduction_Homo sapiens_hsa047401.97996779
12Amphetamine addiction_Homo sapiens_hsa050311.90750065
13Long-term depression_Homo sapiens_hsa047301.85532581
14Cholinergic synapse_Homo sapiens_hsa047251.84960525
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.79528948
16Gap junction_Homo sapiens_hsa045401.70357922
17Taste transduction_Homo sapiens_hsa047421.64501660
18Salivary secretion_Homo sapiens_hsa049701.61025733
19Serotonergic synapse_Homo sapiens_hsa047261.60431860
20Cocaine addiction_Homo sapiens_hsa050301.59203696
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.58955262
22Oxytocin signaling pathway_Homo sapiens_hsa049211.56822470
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.53482776
24Insulin secretion_Homo sapiens_hsa049111.52977849
25Steroid biosynthesis_Homo sapiens_hsa001001.47553594
26Phototransduction_Homo sapiens_hsa047441.46803787
27Gastric acid secretion_Homo sapiens_hsa049711.44858340
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.42699132
29Renin secretion_Homo sapiens_hsa049241.39661335
30ErbB signaling pathway_Homo sapiens_hsa040121.37502792
31Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.35874670
32GnRH signaling pathway_Homo sapiens_hsa049121.31453950
33Parkinsons disease_Homo sapiens_hsa050121.30756061
34Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.24503044
35Melanogenesis_Homo sapiens_hsa049161.23246267
36Glioma_Homo sapiens_hsa052141.19957375
37Calcium signaling pathway_Homo sapiens_hsa040201.19423501
38Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.17834527
39Oxidative phosphorylation_Homo sapiens_hsa001901.17784076
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.16004132
41Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.15618528
42Cardiac muscle contraction_Homo sapiens_hsa042601.14930569
43Estrogen signaling pathway_Homo sapiens_hsa049151.14023037
44Collecting duct acid secretion_Homo sapiens_hsa049661.11235259
45Type II diabetes mellitus_Homo sapiens_hsa049301.10991187
46Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.08481774
47Hedgehog signaling pathway_Homo sapiens_hsa043401.08414882
48cAMP signaling pathway_Homo sapiens_hsa040241.04454363
49Endometrial cancer_Homo sapiens_hsa052131.03614881
50Oocyte meiosis_Homo sapiens_hsa041141.02327229
51Basal cell carcinoma_Homo sapiens_hsa052171.02308300
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.99291955
53Wnt signaling pathway_Homo sapiens_hsa043100.93525255
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92359293
55Colorectal cancer_Homo sapiens_hsa052100.92138594
56Renal cell carcinoma_Homo sapiens_hsa052110.89762565
57Alcoholism_Homo sapiens_hsa050340.89310751
58Phosphatidylinositol signaling system_Homo sapiens_hsa040700.89047480
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.87377284
60Huntingtons disease_Homo sapiens_hsa050160.87157305
61cGMP-PKG signaling pathway_Homo sapiens_hsa040220.86184618
62Vibrio cholerae infection_Homo sapiens_hsa051100.85454631
63Choline metabolism in cancer_Homo sapiens_hsa052310.83986844
64Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.82673533
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.82501722
66VEGF signaling pathway_Homo sapiens_hsa043700.79131788
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.77924600
68Hippo signaling pathway_Homo sapiens_hsa043900.77730731
69Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.75831144
70Notch signaling pathway_Homo sapiens_hsa043300.74163309
71Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73911849
72Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.73357903
73Dilated cardiomyopathy_Homo sapiens_hsa054140.73323126
74MAPK signaling pathway_Homo sapiens_hsa040100.73151884
75Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.67135947
76mTOR signaling pathway_Homo sapiens_hsa041500.66691351
77Butanoate metabolism_Homo sapiens_hsa006500.65514312
78Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.64531115
79Ras signaling pathway_Homo sapiens_hsa040140.62646950
80Non-small cell lung cancer_Homo sapiens_hsa052230.62397852
81Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.61442689
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59861345
83Vascular smooth muscle contraction_Homo sapiens_hsa042700.59635792
84AMPK signaling pathway_Homo sapiens_hsa041520.59423197
85Dorso-ventral axis formation_Homo sapiens_hsa043200.58763348
86Rap1 signaling pathway_Homo sapiens_hsa040150.57762751
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54262851
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.54221758
89Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.54204063
90Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53960909
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.53771001
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52773764
93Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52668684
94mRNA surveillance pathway_Homo sapiens_hsa030150.52439056
95Endocytosis_Homo sapiens_hsa041440.52377558
96Insulin signaling pathway_Homo sapiens_hsa049100.51234600
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50995436
98Circadian rhythm_Homo sapiens_hsa047100.48880774
99Pancreatic secretion_Homo sapiens_hsa049720.48306245
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47002582
101Tight junction_Homo sapiens_hsa045300.46658082
102Alzheimers disease_Homo sapiens_hsa050100.46604217
103Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.46183807
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45436629
105Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.45017318
106Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.43439699
107Thyroid hormone synthesis_Homo sapiens_hsa049180.42320995
108Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41785160
109Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.41022219
110Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40927556
111Arginine and proline metabolism_Homo sapiens_hsa003300.39101601
112Sulfur relay system_Homo sapiens_hsa041220.38434667
113Bile secretion_Homo sapiens_hsa049760.36827055
114Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.36713593
1152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.36510553
116Melanoma_Homo sapiens_hsa052180.33665957
117Prion diseases_Homo sapiens_hsa050200.32976242
118Adherens junction_Homo sapiens_hsa045200.32580383
119Fatty acid metabolism_Homo sapiens_hsa012120.32187784
120Regulation of autophagy_Homo sapiens_hsa041400.31324128

Most similar genes based on co-expression Upload to Enrichr

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