DQX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1plasma lipoprotein particle assembly (GO:0034377)8.00061969
2protein-lipid complex assembly (GO:0065005)7.06076632
3intestinal absorption (GO:0050892)7.05206077
4regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)7.01319065
5low-density lipoprotein particle remodeling (GO:0034374)6.39121996
6angiotensin maturation (GO:0002003)5.85118882
7negative regulation of fibrinolysis (GO:0051918)5.84089236
8plasma lipoprotein particle remodeling (GO:0034369)5.76437883
9protein-lipid complex remodeling (GO:0034368)5.76437883
10macromolecular complex remodeling (GO:0034367)5.76437883
11plasma lipoprotein particle organization (GO:0071827)5.75588107
12fatty acid elongation (GO:0030497)5.59177496
13regulation of cholesterol homeostasis (GO:2000188)5.43995061
14diacylglycerol metabolic process (GO:0046339)5.43366899
15protein-lipid complex subunit organization (GO:0071825)5.37927854
16high-density lipoprotein particle remodeling (GO:0034375)5.24556812
17protein carboxylation (GO:0018214)4.96804544
18peptidyl-glutamic acid carboxylation (GO:0017187)4.96804544
19regulation of fibrinolysis (GO:0051917)4.95497942
20reverse cholesterol transport (GO:0043691)4.76110045
21proline metabolic process (GO:0006560)4.74189301
22lipoprotein transport (GO:0042953)4.73833530
23lipoprotein metabolic process (GO:0042157)4.67907861
24regulation of protein activation cascade (GO:2000257)4.66618416
25regulation of apoptotic cell clearance (GO:2000425)4.65868147
26regulation of complement activation (GO:0030449)4.63448049
27proline biosynthetic process (GO:0006561)4.61654581
28positive regulation of cellular amine metabolic process (GO:0033240)4.44217909
29vitamin transmembrane transport (GO:0035461)4.40962053
30central nervous system myelination (GO:0022010)4.28750209
31axon ensheathment in central nervous system (GO:0032291)4.28750209
32negative regulation of cholesterol transport (GO:0032375)4.07559471
33negative regulation of sterol transport (GO:0032372)4.07559471
34NADH metabolic process (GO:0006734)4.06555974
35regulation of systemic arterial blood pressure by hormone (GO:0001990)4.05833477
36regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)4.05833477
37endocrine process (GO:0050886)4.05833477
38positive regulation of triglyceride lipase activity (GO:0061365)4.05454506
39positive regulation of lipoprotein lipase activity (GO:0051006)4.05454506
40plasma lipoprotein particle clearance (GO:0034381)4.04198749
41cholesterol homeostasis (GO:0042632)4.03160453
42sterol homeostasis (GO:0055092)3.99024413
43fat-soluble vitamin biosynthetic process (GO:0042362)3.96356712
44GPI anchor biosynthetic process (GO:0006506)3.87424934
45positive regulation of fatty acid biosynthetic process (GO:0045723)3.81249674
46glutamine family amino acid biosynthetic process (GO:0009084)3.78503494
47renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.75764619
48drinking behavior (GO:0042756)3.73643950
49preassembly of GPI anchor in ER membrane (GO:0016254)3.71766608
50modified amino acid transport (GO:0072337)3.70117578
51regulation of cholesterol metabolic process (GO:0090181)3.64994316
52regulation of cholesterol biosynthetic process (GO:0045540)3.64504480
53GPI anchor metabolic process (GO:0006505)3.62686238
54fructose metabolic process (GO:0006000)3.61160544
55ribosomal small subunit biogenesis (GO:0042274)3.56188229
56adenosine metabolic process (GO:0046085)3.55753191
57regulation of plasminogen activation (GO:0010755)3.53047618
58fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.52593342
59proteasome assembly (GO:0043248)3.49666237
60aldehyde catabolic process (GO:0046185)3.44895906
61urea cycle (GO:0000050)3.42182928
62regulation of systemic arterial blood pressure (GO:0003073)3.41771132
63epoxygenase P450 pathway (GO:0019373)3.38054332
64transepithelial transport (GO:0070633)3.36939616
65complement activation, classical pathway (GO:0006958)3.35864664
66low-density lipoprotein particle clearance (GO:0034383)3.35594991
67regulation of guanylate cyclase activity (GO:0031282)3.31429264
68GDP-mannose metabolic process (GO:0019673)3.30533921
69cholesterol transport (GO:0030301)3.29044036
70sterol transport (GO:0015918)3.29044036
71positive regulation of defense response to virus by host (GO:0002230)3.28125496
72erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.27912520
73L-phenylalanine catabolic process (GO:0006559)3.27912520
74regulation of activation of Janus kinase activity (GO:0010533)3.27404241
75positive regulation of steroid metabolic process (GO:0045940)3.26588735
76positive regulation of lipid catabolic process (GO:0050996)3.25686594
77COPII vesicle coating (GO:0048208)3.21924896
78very long-chain fatty acid metabolic process (GO:0000038)3.21869919
79intestinal cholesterol absorption (GO:0030299)3.20487279
80lipid homeostasis (GO:0055088)3.19909642
81amyloid precursor protein catabolic process (GO:0042987)3.19067259
82desmosome organization (GO:0002934)3.17990090
83presynaptic membrane assembly (GO:0097105)3.14998599
84maintenance of gastrointestinal epithelium (GO:0030277)3.13434634
85tryptophan metabolic process (GO:0006568)3.13425923
86negative regulation of transcription by competitive promoter binding (GO:0010944)3.11943316
87positive regulation of fatty acid beta-oxidation (GO:0032000)3.11070341
88trivalent inorganic anion homeostasis (GO:0072506)3.11025581
89phosphate ion homeostasis (GO:0055062)3.11025581
90urea metabolic process (GO:0019627)3.10761602
91cholesterol biosynthetic process (GO:0006695)3.09474972
92drug transmembrane transport (GO:0006855)3.09276325
93response to prostaglandin (GO:0034694)3.07980274
94very-low-density lipoprotein particle assembly (GO:0034379)3.07657821
95aromatic amino acid family catabolic process (GO:0009074)3.07282244
96glutamate metabolic process (GO:0006536)3.07115168
97cellular zinc ion homeostasis (GO:0006882)3.06036696
98acute-phase response (GO:0006953)3.04530918
99negative regulation of protein activation cascade (GO:2000258)3.04415137
100chaperone-mediated protein transport (GO:0072321)3.04257613
101regulation of extracellular matrix disassembly (GO:0010715)3.02324067
102C-terminal protein lipidation (GO:0006501)3.01127876
103DNA ligation (GO:0006266)3.00993581
104erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.00623713
105L-phenylalanine metabolic process (GO:0006558)3.00623713
106lung epithelium development (GO:0060428)2.99653664
107amyloid precursor protein metabolic process (GO:0042982)2.98790233
108ethanol oxidation (GO:0006069)2.98639951
109digestive system process (GO:0022600)2.98556399
110regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.98063470
111drug transport (GO:0015893)2.96675860
112protein activation cascade (GO:0072376)2.95490518
113sulfate transmembrane transport (GO:1902358)2.95189286
114positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.95094501
115sterol biosynthetic process (GO:0016126)2.92373930
116regulation of metalloenzyme activity (GO:0048552)2.92360756
117regulation of extracellular matrix organization (GO:1903053)2.91542743
118establishment of integrated proviral latency (GO:0075713)2.89533918
119negative regulation of blood coagulation (GO:0030195)2.88710790
120negative regulation of hemostasis (GO:1900047)2.88710790
121positive regulation of extracellular matrix organization (GO:1903055)2.88071162
122triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.87112332
123regulation of cholesterol esterification (GO:0010872)2.84713498
124omega-hydroxylase P450 pathway (GO:0097267)2.83589733
125L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.81890373
126ribosomal small subunit assembly (GO:0000028)2.81118445
127indole-containing compound catabolic process (GO:0042436)2.79493576
128indolalkylamine catabolic process (GO:0046218)2.79493576
129tryptophan catabolic process (GO:0006569)2.79493576
130positive regulation of T cell mediated cytotoxicity (GO:0001916)2.77722538
131establishment of viral latency (GO:0019043)2.77108682
132glycerophospholipid catabolic process (GO:0046475)2.76080367
133glyoxylate metabolic process (GO:0046487)2.75687915
134amino acid salvage (GO:0043102)2.75445559
135L-methionine salvage (GO:0071267)2.75445559
136L-methionine biosynthetic process (GO:0071265)2.75445559
137transcription elongation from RNA polymerase III promoter (GO:0006385)2.73930533
138termination of RNA polymerase III transcription (GO:0006386)2.73930533
139regulation of memory T cell differentiation (GO:0043380)2.68346954
140serine family amino acid biosynthetic process (GO:0009070)2.66815599
141viral transcription (GO:0019083)2.66540157
142deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.65784685
143NAD biosynthetic process (GO:0009435)2.65533338
144presynaptic membrane organization (GO:0097090)2.65522491
145uronic acid metabolic process (GO:0006063)2.63733157
146glucuronate metabolic process (GO:0019585)2.63733157
147autophagic vacuole fusion (GO:0000046)2.62197882
148neutrophil activation involved in immune response (GO:0002283)2.61984984
149regulation of bile acid biosynthetic process (GO:0070857)2.56786132
150peptide biosynthetic process (GO:0043043)2.55222713
151tyrosine metabolic process (GO:0006570)2.55220037
152translational termination (GO:0006415)2.53882787
153response to folic acid (GO:0051593)2.51707204
154cellular glucuronidation (GO:0052695)2.51303347
155cellular response to hepatocyte growth factor stimulus (GO:0035729)2.50263987
156response to hepatocyte growth factor (GO:0035728)2.50263987
157myelination (GO:0042552)2.48338899
158blood coagulation, intrinsic pathway (GO:0007597)2.46958798
159glycine metabolic process (GO:0006544)2.46786770
160positive regulation of T-helper cell differentiation (GO:0045624)2.46612122
161amine catabolic process (GO:0009310)2.46094441
162cellular biogenic amine catabolic process (GO:0042402)2.46094441
163phospholipid efflux (GO:0033700)2.45312519
164limb bud formation (GO:0060174)2.44857503
165aromatic amino acid family metabolic process (GO:0009072)2.44387558
166regulation of triglyceride catabolic process (GO:0010896)2.43745933
167serine family amino acid metabolic process (GO:0009069)2.43536796
168axon ensheathment (GO:0008366)2.43110361
169ensheathment of neurons (GO:0007272)2.43110361
170positive regulation of interleukin-17 production (GO:0032740)2.42616398
171bile acid biosynthetic process (GO:0006699)2.42525902
172respiratory chain complex IV assembly (GO:0008535)2.42291432
173indolalkylamine metabolic process (GO:0006586)2.42107864
174nitrogen cycle metabolic process (GO:0071941)2.41387879
175response to nitrosative stress (GO:0051409)2.41334830
176positive regulation of cell fate commitment (GO:0010455)2.41062869
177nucleotide transmembrane transport (GO:1901679)2.40443494
178cotranslational protein targeting to membrane (GO:0006613)2.40428035
179oligosaccharide catabolic process (GO:0009313)2.38021656
180deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.36102133
181cholesterol efflux (GO:0033344)2.34793534
182positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.34379972
183leukocyte migration involved in inflammatory response (GO:0002523)2.34186853
184protein targeting to ER (GO:0045047)2.33557101
185pentose metabolic process (GO:0019321)2.33549477
186SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.32854766
187peripheral nervous system neuron development (GO:0048935)2.32795055
188lymphoid progenitor cell differentiation (GO:0002320)2.32577746

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.52235391
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.43773346
3EGR1_23403033_ChIP-Seq_LIVER_Mouse3.87735367
4HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.66179687
5FOXA2_19822575_ChIP-Seq_HepG2_Human3.48297518
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.40772138
7ZNF263_19887448_ChIP-Seq_K562_Human3.33996671
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.30194955
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.29078911
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.88484805
11HNF4A_19822575_ChIP-Seq_HepG2_Human2.84910837
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.83742507
13ESR1_15608294_ChIP-ChIP_MCF-7_Human2.66505369
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.66485280
15GATA4_25053715_ChIP-Seq_YYC3_Human2.65483399
16SOX2_27498859_Chip-Seq_STOMACH_Mouse2.62280268
17CLOCK_20551151_ChIP-Seq_293T_Human2.55840717
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.53940633
19GATA6_25053715_ChIP-Seq_YYC3_Human2.53919705
20PCGF2_27294783_Chip-Seq_ESCs_Mouse2.52357264
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.51559904
22FLI1_27457419_Chip-Seq_LIVER_Mouse2.46423056
23TAF15_26573619_Chip-Seq_HEK293_Human2.45745260
24NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.40421677
25CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.39421791
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.26642291
27AR_21909140_ChIP-Seq_LNCAP_Human2.18247905
28IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.16297462
29GABP_17652178_ChIP-ChIP_JURKAT_Human2.11321836
30IRF8_21731497_ChIP-ChIP_J774_Mouse2.10146893
31FOXO3_23340844_ChIP-Seq_DLD1_Human2.05048415
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.03001012
33RXR_22158963_ChIP-Seq_LIVER_Mouse2.02636814
34RARG_19884340_ChIP-ChIP_MEFs_Mouse2.01352270
35BP1_19119308_ChIP-ChIP_Hs578T_Human1.98903266
36IRF8_22096565_ChIP-ChIP_GC-B_Human1.97947685
37PCGF2_27294783_Chip-Seq_NPCs_Mouse1.96039042
38IRF1_19129219_ChIP-ChIP_H3396_Human1.94464150
39TCF4_18268006_ChIP-ChIP_LS174T_Human1.94233937
40SUZ12_27294783_Chip-Seq_NPCs_Mouse1.88730180
41NFE2_27457419_Chip-Seq_LIVER_Mouse1.86234653
42GBX2_23144817_ChIP-Seq_PC3_Human1.86224468
43FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.85875303
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.83975346
45NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.79179951
46EST1_17652178_ChIP-ChIP_JURKAT_Human1.77929999
47FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.77004081
48TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.76254273
49LXR_22292898_ChIP-Seq_THP-1_Human1.72728036
50MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.70238673
51EZH2_27294783_Chip-Seq_NPCs_Mouse1.69956792
52SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.62497917
53HIF1A_21447827_ChIP-Seq_MCF-7_Human1.57716139
54RUNX1_27457419_Chip-Seq_LIVER_Mouse1.55566900
55RACK7_27058665_Chip-Seq_MCF-7_Human1.55333956
56NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.54143803
57HTT_18923047_ChIP-ChIP_STHdh_Human1.52203145
58PPARA_22158963_ChIP-Seq_LIVER_Mouse1.50992870
59SOX2_20726797_ChIP-Seq_SW620_Human1.50596211
60LXR_22158963_ChIP-Seq_LIVER_Mouse1.50362116
61ESR1_21235772_ChIP-Seq_MCF-7_Human1.50276151
62SUZ12_18555785_Chip-Seq_ESCs_Mouse1.50147538
63SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.48511692
64P300_18555785_Chip-Seq_ESCs_Mouse1.48197043
65EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48073979
66STAT1_20625510_ChIP-Seq_HELA_Human1.47866777
67LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.47347444
68ERG_21242973_ChIP-ChIP_JURKAT_Human1.45086301
69STAT4_19710469_ChIP-ChIP_TH1__Mouse1.45082260
70TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.43645518
71ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.41558136
72GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.41405568
73SALL4_18804426_ChIP-ChIP_XEN_Mouse1.41006068
74ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.39259360
75STAT3_18555785_Chip-Seq_ESCs_Mouse1.37203772
76P53_22387025_ChIP-Seq_ESCs_Mouse1.35283546
77CDX2_20551321_ChIP-Seq_CACO-2_Human1.34544786
78ESR2_21235772_ChIP-Seq_MCF-7_Human1.34350784
79CDX2_19796622_ChIP-Seq_MESCs_Mouse1.32433703
80STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.31709227
81EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.30887316
82EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.30878550
83TAL1_26923725_Chip-Seq_HPCs_Mouse1.28658289
84CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.28464366
85E2F1_18555785_Chip-Seq_ESCs_Mouse1.28276697
86VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.26767469
87RUNX1_27514584_Chip-Seq_MCF-7_Human1.26294495
88CRX_20693478_ChIP-Seq_RETINA_Mouse1.26070240
89TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.25693342
90RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.25532172
91NMYC_18555785_Chip-Seq_ESCs_Mouse1.25276102
92TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23586595
93NOTCH1_21737748_ChIP-Seq_TLL_Human1.23494059
94SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.22557820
95CMYC_18555785_Chip-Seq_ESCs_Mouse1.21812374
96PPAR_26484153_Chip-Seq_NCI-H1993_Human1.21810060
97FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.21616912
98SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.21266809
99EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.21007893
100OCT4_18555785_Chip-Seq_ESCs_Mouse1.20883808
101ER_23166858_ChIP-Seq_MCF-7_Human1.20585259
102POU3F2_20337985_ChIP-ChIP_501MEL_Human1.20544190
103NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.20536704
104E2F7_22180533_ChIP-Seq_HELA_Human1.20509020
105SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.20388600
106KLF4_18555785_Chip-Seq_ESCs_Mouse1.18540151
107SOX2_18555785_Chip-Seq_ESCs_Mouse1.18487182
108FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.17888342
109PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.17781032
110RARA_24833708_ChIP-Seq_LIVER_Mouse1.16838295
111CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.16726117
112NANOG_18555785_Chip-Seq_ESCs_Mouse1.15786064
113ESRRB_18555785_Chip-Seq_ESCs_Mouse1.15761397
114KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.15607045
115* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.14505073
116SMAD1_18555785_Chip-Seq_ESCs_Mouse1.13635119
117IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.13506033
118CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11010220
119ZFX_18555785_Chip-Seq_ESCs_Mouse1.10654306
120PU1_27457419_Chip-Seq_LIVER_Mouse1.10229215
121KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.10095663
122FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.09952602
123ELF1_17652178_ChIP-ChIP_JURKAT_Human1.07259034
124NANOG_20526341_ChIP-Seq_ESCs_Human1.07227594
125SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06357581
126ELK1_19687146_ChIP-ChIP_HELA_Human1.06147822
127PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.05947352
128P63_26484246_Chip-Seq_KERATINOCYTES_Human1.05284157
129GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.04435395
130KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04341310
131VDR_22108803_ChIP-Seq_LS180_Human1.04225353
132HOXB4_20404135_ChIP-ChIP_EML_Mouse1.02704922
133SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.02120360
134NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.01661293
135CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.01186029
136SRF_21415370_ChIP-Seq_HL-1_Mouse1.00922875
137OCT4_21477851_ChIP-Seq_ESCs_Mouse1.00260863
138IRF8_27001747_Chip-Seq_BMDM_Mouse0.98412078
139CTNNB1_20460455_ChIP-Seq_HCT116_Human0.97755025
140TET1_21451524_ChIP-Seq_MESCs_Mouse0.97267454
141SCL_19346495_ChIP-Seq_HPC-7_Human0.96151002
142MYC_18940864_ChIP-ChIP_HL60_Human0.95881278
143JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.95445484
144KAP1_22055183_ChIP-Seq_ESCs_Mouse0.95106669
145POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.94764902
146CTCF_18555785_Chip-Seq_ESCs_Mouse0.94506634
147TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93830478
148JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.93364127
149RARB_24833708_ChIP-Seq_LIVER_Mouse0.93284060
150RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.92433133
151GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.92076670
152NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.91807757
153ETV2_25802403_ChIP-Seq_MESCs_Mouse0.91500748
154* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91427002
155PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.91352153
156GATA1_22025678_ChIP-Seq_K562_Human0.90950889
157FUS_26573619_Chip-Seq_HEK293_Human0.90720105
158ETS1_21867929_ChIP-Seq_TH2_Mouse0.88424710
159GATA3_24758297_ChIP-Seq_MCF-7_Human0.87878162
160NFIB_24661679_ChIP-Seq_LUNG_Mouse0.87841803
161SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.87838634
162TP53_22127205_ChIP-Seq_IMR90_Human0.87717704
163STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.86094303
164FOXA1_25552417_ChIP-Seq_VCAP_Human0.85962227
165FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.85959730
166TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.85175128
167P68_20966046_ChIP-Seq_HELA_Human0.83531302
168DNAJC2_21179169_ChIP-ChIP_NT2_Human0.83013390
169ATF3_27146783_Chip-Seq_COLON_Human0.82903647
170BCOR_27268052_Chip-Seq_Bcells_Human0.82494940
171PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.82164228
172BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.82009320
173* RXRA_24833708_ChIP-Seq_LIVER_Mouse0.81685722
174SMC4_20622854_ChIP-Seq_HELA_Human0.81663909
175STAT3_1855785_ChIP-Seq_MESCs_Mouse0.81221677
176ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.79289730
177ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.77473418
178KLF5_25053715_ChIP-Seq_YYC3_Human0.77329013
179STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.76952836
180CEBPB_22108803_ChIP-Seq_LS180_Human0.75360786
181SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.74886908
182ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.74422004

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis3.76840575
2MP0002139_abnormal_hepatobiliary_system3.65572517
3MP0009379_abnormal_foot_pigmentation3.61741430
4MP0003122_maternal_imprinting3.14620007
5MP0005085_abnormal_gallbladder_physiolo3.11199802
6MP0004264_abnormal_extraembryonic_tissu2.99173975
7MP0000566_synostosis2.80980130
8MP0003183_abnormal_peptide_metabolism2.68237710
9MP0003806_abnormal_nucleotide_metabolis2.53544365
10MP0004381_abnormal_hair_follicle2.52577029
11MP0005365_abnormal_bile_salt2.51699452
12MP0005451_abnormal_body_composition2.46308242
13MP0008875_abnormal_xenobiotic_pharmacok2.45475169
14MP0003136_yellow_coat_color2.36721474
15MP0006292_abnormal_olfactory_placode2.36098837
16MP0000920_abnormal_myelination2.27897560
17MP0009697_abnormal_copulation2.22868130
18MP0005409_darkened_coat_color2.16535531
19MP0000372_irregular_coat_pigmentation2.16199809
20MP0010234_abnormal_vibrissa_follicle2.04947649
21MP0001188_hyperpigmentation2.02585852
22MP0003656_abnormal_erythrocyte_physiolo1.93706879
23MP0001666_abnormal_nutrient_absorption1.92650919
24MP0003724_increased_susceptibility_to1.92612258
25MP0003718_maternal_effect1.90648067
26MP0009785_altered_susceptibility_to1.89593716
27MP0005083_abnormal_biliary_tract1.87331842
28MP0003123_paternal_imprinting1.74997177
29MP0001986_abnormal_taste_sensitivity1.74135874
30MP0000383_abnormal_hair_follicle1.72088936
31MP0002089_abnormal_postnatal_growth/wei1.69586920
32MP0003868_abnormal_feces_composition1.64707596
33MP0005058_abnormal_lysosome_morphology1.63096384
34MP0002148_abnormal_hypersensitivity_rea1.62826406
35MP0001346_abnormal_lacrimal_gland1.62583671
36MP0003195_calcinosis1.61834919
37MP0000609_abnormal_liver_physiology1.57652380
38MP0009840_abnormal_foam_cell1.54833548
39MP0005025_abnormal_response_to1.54377952
40MP0004742_abnormal_vestibular_system1.54257355
41MP0004147_increased_porphyrin_level1.51535126
42MP0009333_abnormal_splenocyte_physiolog1.46722759
43MP0005671_abnormal_response_to1.45039665
44MP0002638_abnormal_pupillary_reflex1.43668238
45MP0002277_abnormal_respiratory_mucosa1.41178843
46MP0001835_abnormal_antigen_presentation1.38638741
47MP0002751_abnormal_autonomic_nervous1.38258674
48MP0005171_absent_coat_pigmentation1.37175976
49MP0005379_endocrine/exocrine_gland_phen1.37140586
50MP0003567_abnormal_fetal_cardiomyocyte1.35588308
51MP0004043_abnormal_pH_regulation1.34800481
52MP0000477_abnormal_intestine_morphology1.33876338
53MP0005332_abnormal_amino_acid1.33370717
54MP0002419_abnormal_innate_immunity1.31292880
55MP0001270_distended_abdomen1.30562789
56MP0005000_abnormal_immune_tolerance1.29738481
57MP0001664_abnormal_digestion1.29691986
58MP0009643_abnormal_urine_homeostasis1.27963034
59MP0004019_abnormal_vitamin_homeostasis1.27930517
60MP0005408_hypopigmentation1.26352735
61MP0003436_decreased_susceptibility_to1.25884950
62MP0010329_abnormal_lipoprotein_level1.22520892
63MP0002876_abnormal_thyroid_physiology1.22437063
64MP0000678_abnormal_parathyroid_gland1.20154623
65MP0002723_abnormal_immune_serum1.18369853
66MP0005387_immune_system_phenotype1.18205804
67MP0001790_abnormal_immune_system1.18205804
68MP0000538_abnormal_urinary_bladder1.17950908
69MP0003315_abnormal_perineum_morphology1.17601863
70MP0008469_abnormal_protein_level1.17397793
71MP0009765_abnormal_xenobiotic_induced1.16783029
72MP0002132_abnormal_respiratory_system1.15297514
73MP0003172_abnormal_lysosome_physiology1.15287433
74MP0005257_abnormal_intraocular_pressure1.14662713
75MP0001485_abnormal_pinna_reflex1.13781985
76MP0006082_CNS_inflammation1.13285678
77MP0002098_abnormal_vibrissa_morphology1.13186181
78MP0003252_abnormal_bile_duct1.12065607
79MP0005174_abnormal_tail_pigmentation1.12040315
80MP0001800_abnormal_humoral_immune1.11154340
81MP0000685_abnormal_immune_system1.09900354
82MP0008057_abnormal_DNA_replication1.08829988
83MP0004858_abnormal_nervous_system1.08112822
84MP0000462_abnormal_digestive_system1.06852341
85MP0003186_abnormal_redox_activity1.06577311
86MP0002933_joint_inflammation1.06121752
87MP0001765_abnormal_ion_homeostasis1.05229525
88MP0003763_abnormal_thymus_physiology1.03279516
89MP0003690_abnormal_glial_cell1.01701846
90MP0002452_abnormal_antigen_presenting1.01164974
91MP0009764_decreased_sensitivity_to1.00597111
92MP0001756_abnormal_urination0.99508003
93MP0005464_abnormal_platelet_physiology0.98901789
94MP0001764_abnormal_homeostasis0.98567890
95MP0002166_altered_tumor_susceptibility0.98512483
96MP0005084_abnormal_gallbladder_morpholo0.98368436
97MP0001905_abnormal_dopamine_level0.97945820
98MP0002163_abnormal_gland_morphology0.96930991
99MP0005076_abnormal_cell_differentiation0.96806595
100MP0003938_abnormal_ear_development0.95552936
101MP0001819_abnormal_immune_cell0.95276086
102MP0002420_abnormal_adaptive_immunity0.94200536
103MP0006054_spinal_hemorrhage0.93760620
104MP0000613_abnormal_salivary_gland0.92753312
105MP0004142_abnormal_muscle_tone0.92019757
106MP0003950_abnormal_plasma_membrane0.91729010
107MP0003880_abnormal_central_pattern0.91222330
108MP0009763_increased_sensitivity_to0.86908130
109MP0005448_abnormal_energy_balance0.86182803
110MP0010155_abnormal_intestine_physiology0.85809436
111MP0005319_abnormal_enzyme/_coenzyme0.85412510
112MP0001661_extended_life_span0.85386241
113MP0002138_abnormal_hepatobiliary_system0.85224658
114MP0003011_delayed_dark_adaptation0.83857930
115MP0008007_abnormal_cellular_replicative0.83810429
116MP0009642_abnormal_blood_homeostasis0.81230321
117MP0005381_digestive/alimentary_phenotyp0.81134076
118MP0001919_abnormal_reproductive_system0.80906849
119MP0010678_abnormal_skin_adnexa0.80503155
120MP0003866_abnormal_defecation0.78648313
121MP0000598_abnormal_liver_morphology0.78551417
122MP0005670_abnormal_white_adipose0.78397935
123MP0002938_white_spotting0.77576836
124MP0009115_abnormal_fat_cell0.77324164
125MP0010352_gastrointestinal_tract_polyps0.77212592
126MP0002009_preneoplasia0.76571498
127MP0008260_abnormal_autophagy0.76168211
128MP0000716_abnormal_immune_system0.75960986
129MP0002118_abnormal_lipid_homeostasis0.73260685
130MP0001915_intracranial_hemorrhage0.72942827
131MP0001663_abnormal_digestive_system0.70543849
132MP0004270_analgesia0.69868426
133MP0003941_abnormal_skin_development0.69829272
134MP0005075_abnormal_melanosome_morpholog0.68674089
135MP0008058_abnormal_DNA_repair0.67813197
136MP0001845_abnormal_inflammatory_respons0.67241380
137MP0009780_abnormal_chondrocyte_physiolo0.67039940
138MP0005636_abnormal_mineral_homeostasis0.66588988
139MP0005584_abnormal_enzyme/coenzyme_acti0.66445049
140MP0000604_amyloidosis0.65519135
141MP0000015_abnormal_ear_pigmentation0.65190637
142MP0002136_abnormal_kidney_physiology0.64955669
143MP0003453_abnormal_keratinocyte_physiol0.64835642
144MP0001348_abnormal_lacrimal_gland0.64209792
145MP0004782_abnormal_surfactant_physiolog0.63268147
146MP0003953_abnormal_hormone_level0.61807336
147MP0002971_abnormal_brown_adipose0.61650291
148MP0003879_abnormal_hair_cell0.60346549
149MP0003329_amyloid_beta_deposits0.59862534
150MP0000490_abnormal_crypts_of0.59582718
151MP0002006_tumorigenesis0.59243761
152MP0002896_abnormal_bone_mineralization0.58750758
153MP0006138_congestive_heart_failure0.57112501
154MP0002909_abnormal_adrenal_gland0.56868760
155MP0010368_abnormal_lymphatic_system0.55604561
156MP0002078_abnormal_glucose_homeostasis0.55343806
157MP0003943_abnormal_hepatobiliary_system0.54966586
158MP0004185_abnormal_adipocyte_glucose0.54416997
159MP0002086_abnormal_extraembryonic_tissu0.53177902
160MP0001849_ear_inflammation0.52534892
161MP0009384_cardiac_valve_regurgitation0.51903428
162MP0003115_abnormal_respiratory_system0.51417133
163MP0005666_abnormal_adipose_tissue0.51033267
164MP0003121_genomic_imprinting0.49969158
165MP0003566_abnormal_cell_adhesion0.49399977
166MP0005410_abnormal_fertilization0.48327385
167MP0001730_embryonic_growth_arrest0.47579391

Predicted human phenotypes

RankGene SetZ-score
1Acanthocytosis (HP:0001927)4.79951446
2Hemorrhage of the eye (HP:0011885)4.53382374
3Parakeratosis (HP:0001036)4.51224559
4Complement deficiency (HP:0004431)4.32592062
5Asymmetry of the thorax (HP:0001555)4.26673572
6Systemic lupus erythematosus (HP:0002725)4.24539194
7Flat acetabular roof (HP:0003180)4.18120777
8Sensory axonal neuropathy (HP:0003390)4.02237424
9Duplicated collecting system (HP:0000081)4.01580093
10Hypercholesterolemia (HP:0003124)3.89964660
11Hypolipoproteinemia (HP:0010981)3.85961538
12Hydroxyprolinuria (HP:0003080)3.80464950
13Abnormality of proline metabolism (HP:0010907)3.80464950
14Abnormality of carpal bone ossification (HP:0006257)3.77587844
15Abnormality of the common coagulation pathway (HP:0010990)3.76764691
16Epidermoid cyst (HP:0200040)3.72111458
17Widely patent fontanelles and sutures (HP:0004492)3.52756833
18Abnormality of the renal collecting system (HP:0004742)3.49105626
19Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.42898974
20Abnormality of complement system (HP:0005339)3.39005248
21Abnormal tarsal ossification (HP:0008369)3.33573418
22Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.17620653
23Pigmentary retinal degeneration (HP:0001146)3.17227683
24Small epiphyses (HP:0010585)3.14129307
25Prolonged partial thromboplastin time (HP:0003645)3.11046303
26Facial shape deformation (HP:0011334)2.99000169
27Potter facies (HP:0002009)2.99000169
28Malnutrition (HP:0004395)2.97218374
29Abnormality of aromatic amino acid family metabolism (HP:0004338)2.94258476
30Seborrheic dermatitis (HP:0001051)2.89500788
31Renal Fanconi syndrome (HP:0001994)2.89250938
32Abnormal ossification of hand bones (HP:0005921)2.84331436
33Abnormal hand bone ossification (HP:0010660)2.83211939
34Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.78436819
35Wide cranial sutures (HP:0010537)2.78272231
36Abnormality of the axillary hair (HP:0100134)2.70034768
37Abnormality of secondary sexual hair (HP:0009888)2.70034768
38Hypothermia (HP:0002045)2.69191070
39Joint hemorrhage (HP:0005261)2.68440415
40Skin nodule (HP:0200036)2.67996347
41Increased hepatocellular lipid droplets (HP:0006565)2.64772601
42Menorrhagia (HP:0000132)2.62651653
43Macrocytic anemia (HP:0001972)2.60909422
44Prolonged neonatal jaundice (HP:0006579)2.58939080
45Thyroid-stimulating hormone excess (HP:0002925)2.57833878
46Abnormality of the nasal septum (HP:0000419)2.55899483
47Hypobetalipoproteinemia (HP:0003563)2.55868670
48Abnormality of monocarboxylic acid metabolism (HP:0010996)2.55430744
49Type I transferrin isoform profile (HP:0003642)2.52535463
50Vaginal fistula (HP:0004320)2.51195948
513-Methylglutaconic aciduria (HP:0003535)2.50054717
52Abnormality of methionine metabolism (HP:0010901)2.49287374
53Spontaneous abortion (HP:0005268)2.48706969
54Hypotension (HP:0002615)2.47354433
55Premature skin wrinkling (HP:0100678)2.47353389
56Lipid accumulation in hepatocytes (HP:0006561)2.45747152
57Right ventricular cardiomyopathy (HP:0011663)2.45080336
58Cerebral hypomyelination (HP:0006808)2.40798059
59Intrahepatic cholestasis (HP:0001406)2.37177853
60Abnormal hemoglobin (HP:0011902)2.36555919
61Abnormality of urine glucose concentration (HP:0011016)2.35595904
62Glycosuria (HP:0003076)2.35595904
63Hyperlipoproteinemia (HP:0010980)2.34646649
64Cardiovascular calcification (HP:0011915)2.34437222
65Broad alveolar ridges (HP:0000187)2.34223738
66Abnormality of aspartate family amino acid metabolism (HP:0010899)2.34201846
67Abnormality of glycine metabolism (HP:0010895)2.32957936
68Abnormality of serine family amino acid metabolism (HP:0010894)2.32957936
69Broad palm (HP:0001169)2.30896418
70Proximal tubulopathy (HP:0000114)2.30893708
71Asplenia (HP:0001746)2.30782277
72Purpura (HP:0000979)2.28278108
73Stomatitis (HP:0010280)2.27443359
74Metaphyseal irregularity (HP:0003025)2.27031664
75Irregular epiphyses (HP:0010582)2.26763873
76Exertional dyspnea (HP:0002875)2.23632920
77Xanthomatosis (HP:0000991)2.23515346
78Fat malabsorption (HP:0002630)2.21287633
79Epiphyseal dysplasia (HP:0002656)2.20373699
80Abnormal urine phosphate concentration (HP:0012599)2.18006835
81Recurrent skin infections (HP:0001581)2.16469866
82Absent septum pellucidum (HP:0001331)2.15835423
83Reticulocytopenia (HP:0001896)2.14982192
84Anomalous pulmonary venous return (HP:0010772)2.14623428
85Abnormal number of erythroid precursors (HP:0012131)2.14526857
86Abnormality of pyrimidine metabolism (HP:0004353)2.14118837
87Hypoglycemic coma (HP:0001325)2.13826434
88Poikilocytosis (HP:0004447)2.13549203
89Nephritis (HP:0000123)2.12905392
90Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.11732344
91Autoimmune hemolytic anemia (HP:0001890)2.11110680
92Conjugated hyperbilirubinemia (HP:0002908)2.10366522
93Rickets (HP:0002748)2.10204987
94Thin bony cortex (HP:0002753)2.10130960
95Deep venous thrombosis (HP:0002625)2.10093066
96Alacrima (HP:0000522)2.09746411
97Abnormality of the lumbar spine (HP:0100712)2.09543201
98Progressive external ophthalmoplegia (HP:0000590)2.09126073
99Flared iliac wings (HP:0002869)2.08482421
100Chronic otitis media (HP:0000389)2.08425468
101Reduced antithrombin III activity (HP:0001976)2.06707574
102Aplasia/Hypoplasia of the spleen (HP:0010451)2.06340529
103Hyperphosphaturia (HP:0003109)2.06086919
104Megaloblastic anemia (HP:0001889)2.04233815
105Renal cortical cysts (HP:0000803)2.03668349
106Recurrent abscess formation (HP:0002722)2.02195900
107Recurrent pneumonia (HP:0006532)2.01002658
108Aplasia/Hypoplasia involving the musculature (HP:0001460)2.00285217
109Hyperammonemia (HP:0001987)1.99986835
110Cupped ribs (HP:0000887)1.98677980
111Hypoplasia of the capital femoral epiphysis (HP:0003090)1.97653000
112Abnormal foot bone ossification (HP:0010675)1.96376825
113Abnormality of cells of the erythroid lineage (HP:0012130)1.95756411
114Increased intramyocellular lipid droplets (HP:0012240)1.95336142
115Supernumerary spleens (HP:0009799)1.93733429
116Nonprogressive disorder (HP:0003680)1.93010087
117Abnormality of the septum pellucidum (HP:0007375)1.92830423
118Fair hair (HP:0002286)1.92757638
119Optic disc pallor (HP:0000543)1.91862393
120Hypoalphalipoproteinemia (HP:0003233)1.91800394
121Glomerulonephritis (HP:0000099)1.91091669
122Hyperglycinuria (HP:0003108)1.89870033
123Patchy hypopigmentation of hair (HP:0011365)1.89385642
124Abnormality of glutamine family amino acid metabolism (HP:0010902)1.89193896
125Pancreatic islet-cell hyperplasia (HP:0004510)1.88713270
126Chronic diarrhea (HP:0002028)1.88349567
127Gingival bleeding (HP:0000225)1.88257321
128Hepatosplenomegaly (HP:0001433)1.88224189
129Abnormality of T cell number (HP:0011839)1.87835212
130Delayed epiphyseal ossification (HP:0002663)1.87811274
131Steatorrhea (HP:0002570)1.87755354
132Abnormality of vitamin metabolism (HP:0100508)1.86487060
133Ileus (HP:0002595)1.85522804
134Increased serum pyruvate (HP:0003542)1.84892882
135Abnormality of placental membranes (HP:0011409)1.84255530
136Amniotic constriction ring (HP:0009775)1.84255530
137Hepatocellular carcinoma (HP:0001402)1.83261497
138Nasolacrimal duct obstruction (HP:0000579)1.83257226
139Abnormality of eosinophils (HP:0001879)1.83102195
140Chronic obstructive pulmonary disease (HP:0006510)1.82317168
141Obstructive lung disease (HP:0006536)1.82317168
142Eosinophilia (HP:0001880)1.81783572
143Decreased central vision (HP:0007663)1.81445595
144Conical tooth (HP:0000698)1.80684206
145Abnormality of the pulmonary veins (HP:0011718)1.80319793
146Abnormality of B cell number (HP:0010975)1.80236135
147B lymphocytopenia (HP:0010976)1.80236135
148Granulocytopenia (HP:0001913)1.79934463
149Hypomagnesemia (HP:0002917)1.79454066
150Vascular calcification (HP:0004934)1.79060268
151T lymphocytopenia (HP:0005403)1.79055827
152Abnormality of the vitamin B12 metabolism (HP:0004341)1.78394830
153Abnormality of the acetabulum (HP:0003170)1.78109142
154Enlarged kidneys (HP:0000105)1.77910484
155Elevated erythrocyte sedimentation rate (HP:0003565)1.77545729
156Abnormality of the wing of the ilium (HP:0011867)1.76883299
157Abnormality of small intestinal villus morphology (HP:0011472)1.76503743
158Villous atrophy (HP:0011473)1.76503743
159Thick nail (HP:0001805)1.76197736
160Abnormality of renal resorption (HP:0011038)1.75770250
161Neonatal death (HP:0003811)1.74849023
162Recurrent bacterial skin infections (HP:0005406)1.73943251
163Prostate neoplasm (HP:0100787)1.73739974
164Pallor (HP:0000980)1.73552416
165Abnormality of magnesium homeostasis (HP:0004921)1.73507537
166Overfolded helix (HP:0000396)1.72983671
167Hypophosphatemia (HP:0002148)1.72876166
168Hepatoblastoma (HP:0002884)1.72664397
169Redundant skin (HP:0001582)1.72444172
170Hypophosphatemic rickets (HP:0004912)1.72081400
171Aplasia cutis congenita (HP:0001057)1.70985260
172Renal tubular dysfunction (HP:0000124)1.70479093
173Osteomalacia (HP:0002749)1.69755860
174Limited elbow extension (HP:0001377)1.69139481
175Glomerulosclerosis (HP:0000096)1.68520884
176Abnormality of glycolysis (HP:0004366)1.68103268
177Diastasis recti (HP:0001540)1.66934896
178Hyperactive renin-angiotensin system (HP:0000841)1.64690832
179Nephrolithiasis (HP:0000787)1.62115325
180Abnormality of the intrinsic pathway (HP:0010989)1.62114657

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FGFR46.28034105
2TNIK4.41253099
3FGFR34.06501220
4ICK3.59948047
5CASK3.57134230
6STK393.24220987
7TLK13.18184082
8RIPK12.99326969
9TYRO32.85282232
10PIK3CA2.79742057
11EPHB12.78714513
12CDK122.77242342
13PBK2.60447516
14MST42.59987336
15EPHA22.58505031
16ERN12.54546323
17IRAK42.50414130
18ACVR1B2.49865029
19CLK12.28528564
20IRAK32.12298820
21OXSR12.02670390
22PDGFRA1.98655455
23VRK11.90963859
24TAOK31.85318250
25TRIB31.81990533
26DDR21.79492882
27MAP3K101.75511471
28CDK191.73090332
29MAP3K141.69637662
30SRPK11.69462462
31MATK1.66958250
32FGFR11.65063292
33TXK1.63368978
34BCKDK1.62931812
35MAPKAPK51.58516925
36STK161.57520804
37EEF2K1.55493295
38RET1.54434306
39NME21.52805855
40MKNK11.51851296
41DYRK1B1.48386307
42MAP3K21.44362559
43BMPR1B1.40856580
44IKBKE1.40295443
45WNK11.39432529
46MAPK111.38862594
47EIF2AK11.38485007
48NLK1.38330456
49IKBKB1.34141711
50MKNK21.30649698
51STK241.30282838
52NEK61.29024893
53IRAK11.27975797
54EIF2AK21.27105146
55MUSK1.24666696
56BCR1.22436429
57IRAK21.21259776
58PRKG21.20572079
59ERBB21.14443645
60FER1.14043054
61PRKD21.13924176
62PDPK11.11948286
63PRKAA21.10796079
64INSRR1.10144867
65MAPK151.08934758
66YES11.08775845
67WNK41.07943788
68PTK61.05653419
69PKN21.03099679
70PIK3CG1.01201792
71NTRK10.99527231
72EIF2AK30.96786858
73LMTK20.95873792
74MAP2K20.94018465
75SMG10.92013915
76PKN10.91599918
77TEC0.88787906
78ADRBK20.88558706
79PTK20.88506940
80CAMK2B0.84505395
81CSK0.81833235
82BUB10.80710983
83TBK10.80365541
84PDK20.79403243
85ZAK0.77414979
86GRK70.77151588
87ERBB40.75995056
88PDK10.74848081
89BMPR20.73427044
90CDC42BPA0.73241589
91STK40.71963680
92AKT30.71917342
93STK100.70495815
94TNK20.68109818
95BTK0.67070405
96KIT0.66133410
97RPS6KB10.65854845
98EPHA30.65286014
99CDK60.64841790
100MAP3K10.64418012
101SIK20.64164803
102LYN0.63965907
103GRK10.63116287
104MELK0.62971133
105LATS10.62955069
106PIM20.62495472
107MAP2K60.62052219
108BRSK10.61150070
109MST1R0.60508265
110ABL20.60062727
111MET0.58070767
112LCK0.57171902
113RPS6KA50.55600541
114PIM10.52874275
115TYK20.52469555
116NUAK10.52160728
117MAP4K10.51231684
118CDK70.50764745
119CAMK2D0.50761160
120UHMK10.49266334
121PRKCQ0.49175738
122ROCK20.47544461
123NME10.47522650
124SIK10.47501228
125NEK20.47311485
126GRK60.46348004
127PLK40.45230122
128ALK0.44730531
129MTOR0.44340564
130SGK10.43808862
131SGK2230.43386572
132SGK4940.43386572
133SRC0.43271849
134PRKCZ0.42381209
135NEK90.41907722
136TRPM70.41765785
137MAPK40.41699172
138HIPK20.40582409
139TESK20.40386801
140BRSK20.39783638
141PRKAA10.38401939
142MAPKAPK30.38394327
143FES0.37752753
144EPHA40.37738062
145CSNK1E0.37118713
146PRKCE0.34962526
147PRKACG0.33285097
148CDK80.33272982
149ABL10.33261527
150BRD40.33022759
151KSR20.32336086
152FGR0.31656060
153IGF1R0.31653650
154CSNK2A10.31560646
155MAPK70.31443948
156LATS20.31346659
157PRKCD0.31062524
158CAMK2G0.30826879
159FLT30.30053587
160CSNK1G10.29849487
161CSNK2A20.29588740
162PDGFRB0.28937686
163MAP3K70.28762045
164FGFR20.28731677
165SYK0.28419861
166MAP2K10.28395994
167SGK30.28276497
168STK110.27484322
169PRKG10.27362272
170SCYL20.27085790
171CDK40.26311992
172CSF1R0.25955416
173STK38L0.22133928
174PRKCI0.20954946
175ITK0.19798944

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid elongation_Homo sapiens_hsa000623.04549752
2Ribosome_Homo sapiens_hsa030102.83413857
3Renin-angiotensin system_Homo sapiens_hsa046142.77490472
4Histidine metabolism_Homo sapiens_hsa003402.55296476
5Steroid biosynthesis_Homo sapiens_hsa001002.54867779
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.41615092
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.32604618
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.31333650
9Folate biosynthesis_Homo sapiens_hsa007902.27639734
10Fructose and mannose metabolism_Homo sapiens_hsa000512.25544067
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.20047960
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.12254968
13Primary bile acid biosynthesis_Homo sapiens_hsa001202.11524728
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.95384970
15Fatty acid biosynthesis_Homo sapiens_hsa000611.94938562
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.94880374
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.94239088
18Protein export_Homo sapiens_hsa030601.86823329
19RNA polymerase_Homo sapiens_hsa030201.86166930
20Pentose and glucuronate interconversions_Homo sapiens_hsa000401.82368454
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.74402389
22Sulfur metabolism_Homo sapiens_hsa009201.66688556
23Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.66533303
24Peroxisome_Homo sapiens_hsa041461.63514370
25Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.62664561
26Ether lipid metabolism_Homo sapiens_hsa005651.61691628
27Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.59134970
28Bile secretion_Homo sapiens_hsa049761.58839697
29One carbon pool by folate_Homo sapiens_hsa006701.58598424
30Steroid hormone biosynthesis_Homo sapiens_hsa001401.56498542
31Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.49750392
32Phenylalanine metabolism_Homo sapiens_hsa003601.49543904
33Caffeine metabolism_Homo sapiens_hsa002321.47650105
34Proteasome_Homo sapiens_hsa030501.45444546
35Galactose metabolism_Homo sapiens_hsa000521.45006885
36Vitamin digestion and absorption_Homo sapiens_hsa049771.43719252
37Oxidative phosphorylation_Homo sapiens_hsa001901.41504177
38beta-Alanine metabolism_Homo sapiens_hsa004101.41491003
39Pyrimidine metabolism_Homo sapiens_hsa002401.41282099
40Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.40303783
41Non-homologous end-joining_Homo sapiens_hsa034501.40117425
42Tryptophan metabolism_Homo sapiens_hsa003801.38694064
43Graft-versus-host disease_Homo sapiens_hsa053321.37348074
44Protein digestion and absorption_Homo sapiens_hsa049741.35730149
45Fanconi anemia pathway_Homo sapiens_hsa034601.33622049
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.31013306
47Chemical carcinogenesis_Homo sapiens_hsa052041.28942849
48Retinol metabolism_Homo sapiens_hsa008301.27850133
49Arginine and proline metabolism_Homo sapiens_hsa003301.27455804
50Complement and coagulation cascades_Homo sapiens_hsa046101.26906153
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.22381180
52Glycerolipid metabolism_Homo sapiens_hsa005611.20568214
53Drug metabolism - other enzymes_Homo sapiens_hsa009831.20107001
54Linoleic acid metabolism_Homo sapiens_hsa005911.18334247
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.17438395
56Staphylococcus aureus infection_Homo sapiens_hsa051501.16306036
57Glutathione metabolism_Homo sapiens_hsa004801.14568323
58Other glycan degradation_Homo sapiens_hsa005111.13986096
59Arachidonic acid metabolism_Homo sapiens_hsa005901.13795192
60Butanoate metabolism_Homo sapiens_hsa006501.11368505
61Tyrosine metabolism_Homo sapiens_hsa003501.10350437
62Fat digestion and absorption_Homo sapiens_hsa049751.09863924
63Homologous recombination_Homo sapiens_hsa034401.08428459
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.08356320
65Sphingolipid metabolism_Homo sapiens_hsa006001.08109088
66alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.07996492
67Allograft rejection_Homo sapiens_hsa053301.05092670
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.04223221
69Maturity onset diabetes of the young_Homo sapiens_hsa049501.01975506
70Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.00260483
71Carbohydrate digestion and absorption_Homo sapiens_hsa049730.98381525
72Biosynthesis of amino acids_Homo sapiens_hsa012300.95454821
73N-Glycan biosynthesis_Homo sapiens_hsa005100.94698470
74Glycosaminoglycan degradation_Homo sapiens_hsa005310.92574823
75Fatty acid degradation_Homo sapiens_hsa000710.92049625
76Primary immunodeficiency_Homo sapiens_hsa053400.90954110
77DNA replication_Homo sapiens_hsa030300.87842670
78Intestinal immune network for IgA production_Homo sapiens_hsa046720.87466093
79Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.85879380
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.85533262
81Parkinsons disease_Homo sapiens_hsa050120.85142204
82Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.84428592
83Cyanoamino acid metabolism_Homo sapiens_hsa004600.84225967
84Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.78674636
85Thyroid hormone synthesis_Homo sapiens_hsa049180.78130447
86Fatty acid metabolism_Homo sapiens_hsa012120.76918298
87Purine metabolism_Homo sapiens_hsa002300.76596650
88Metabolic pathways_Homo sapiens_hsa011000.75236513
89NF-kappa B signaling pathway_Homo sapiens_hsa040640.74975052
90Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.74585633
91Starch and sucrose metabolism_Homo sapiens_hsa005000.73439958
92Autoimmune thyroid disease_Homo sapiens_hsa053200.72371233
93Alzheimers disease_Homo sapiens_hsa050100.70756570
94Nitrogen metabolism_Homo sapiens_hsa009100.70241785
95Pyruvate metabolism_Homo sapiens_hsa006200.66261654
96Cysteine and methionine metabolism_Homo sapiens_hsa002700.65767261
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.65695381
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.65153113
99Vitamin B6 metabolism_Homo sapiens_hsa007500.64447330
100Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63688605
101Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63316665
102ABC transporters_Homo sapiens_hsa020100.63249142
103Carbon metabolism_Homo sapiens_hsa012000.63081208
104Insulin resistance_Homo sapiens_hsa049310.62557874
105Hematopoietic cell lineage_Homo sapiens_hsa046400.62110914
106Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.62068404
107Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61404524
108RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.60453131
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.59805098
110Mismatch repair_Homo sapiens_hsa034300.55245510
111Huntingtons disease_Homo sapiens_hsa050160.54890439
112Spliceosome_Homo sapiens_hsa030400.54132732
113Arginine biosynthesis_Homo sapiens_hsa002200.53003824
114Basal transcription factors_Homo sapiens_hsa030220.52992898
115Rheumatoid arthritis_Homo sapiens_hsa053230.51583490
116Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.49813022
117PPAR signaling pathway_Homo sapiens_hsa033200.49418847
118Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47430144
119Glucagon signaling pathway_Homo sapiens_hsa049220.47349188
120Malaria_Homo sapiens_hsa051440.43457065
121Lysine degradation_Homo sapiens_hsa003100.43377350
122Propanoate metabolism_Homo sapiens_hsa006400.40428208
123Sulfur relay system_Homo sapiens_hsa041220.38731139
124Selenocompound metabolism_Homo sapiens_hsa004500.37587796
125Mineral absorption_Homo sapiens_hsa049780.37552599
126Measles_Homo sapiens_hsa051620.36191181
127NOD-like receptor signaling pathway_Homo sapiens_hsa046210.35407988
128Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.34943812
129Pertussis_Homo sapiens_hsa051330.32605940
130Systemic lupus erythematosus_Homo sapiens_hsa053220.29473401
131Pancreatic secretion_Homo sapiens_hsa049720.24053221
132AMPK signaling pathway_Homo sapiens_hsa041520.21720369
133Prion diseases_Homo sapiens_hsa050200.20762291
134Insulin signaling pathway_Homo sapiens_hsa049100.17650560
135Thyroid cancer_Homo sapiens_hsa052160.17199593
136Central carbon metabolism in cancer_Homo sapiens_hsa052300.14279786
137Non-small cell lung cancer_Homo sapiens_hsa052230.13032087
138Phosphatidylinositol signaling system_Homo sapiens_hsa040700.12943841
139Pentose phosphate pathway_Homo sapiens_hsa000300.11604621
140Inositol phosphate metabolism_Homo sapiens_hsa005620.09727287
141Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.08350680
142HIF-1 signaling pathway_Homo sapiens_hsa040660.08095257
143Choline metabolism in cancer_Homo sapiens_hsa052310.07376897

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