DRAM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is regulated as part of the p53 tumor suppressor pathway. The gene encodes a lysosomal membrane protein that is required for the induction of autophagy by the pathway. Decreased transcriptional expression of this gene is associated with various tumors. This gene has a pseudogene on chromosome 4. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chemical homeostasis within a tissue (GO:0048875)9.25231444
2regulation of vitamin D biosynthetic process (GO:0060556)4.78386198
3negative regulation of interleukin-12 production (GO:0032695)4.55045768
4low-density lipoprotein particle clearance (GO:0034383)4.45515427
5pattern specification involved in kidney development (GO:0061004)4.04675930
6regulation of T-helper 1 cell differentiation (GO:0045625)4.04297244
7negative regulation of nitric oxide biosynthetic process (GO:0045019)3.94047210
8positive regulation of chemokine biosynthetic process (GO:0045080)3.91939351
9neutrophil activation involved in immune response (GO:0002283)3.89081479
10positive regulation by symbiont of host defense response (GO:0052509)3.79926808
11modulation by symbiont of host defense response (GO:0052031)3.79926808
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.79926808
13modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.79926808
14positive regulation by organism of defense response of other organism involved in symbiotic interact3.79926808
15modulation by symbiont of host immune response (GO:0052553)3.79926808
16regulation of vitamin metabolic process (GO:0030656)3.77633132
17positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.75906600
18regulation of cytokine secretion involved in immune response (GO:0002739)3.66028765
19dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.63431729
20response to peptidoglycan (GO:0032494)3.62514089
21antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.56585392
22regulation of cholesterol storage (GO:0010885)3.52302501
23positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.37851948
24regulation of chronic inflammatory response (GO:0002676)3.34595453
25regulation of membrane protein ectodomain proteolysis (GO:0051043)3.33505373
26antigen processing and presentation of endogenous antigen (GO:0019883)3.31011219
27lung lobe morphogenesis (GO:0060463)3.27019174
28antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.25783448
29antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.25783448
30apoptotic cell clearance (GO:0043277)3.25707219
31cellular response to nitric oxide (GO:0071732)3.23257848
32regulation of macrophage chemotaxis (GO:0010758)3.22489323
33positive regulation of heat generation (GO:0031652)3.19198856
34macrophage chemotaxis (GO:0048246)3.19023867
35myeloid dendritic cell differentiation (GO:0043011)3.17859078
36positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.15733612
37cell adhesion mediated by integrin (GO:0033627)3.15019962
38response to xenobiotic stimulus (GO:0009410)3.12398659
39regulation of nitric oxide biosynthetic process (GO:0045428)3.11716871
40NIK/NF-kappaB signaling (GO:0038061)3.10936901
41response to hyperoxia (GO:0055093)3.08153511
42response to increased oxygen levels (GO:0036296)3.08153511
43leukocyte mediated cytotoxicity (GO:0001909)3.07519352
44cellular response to interferon-alpha (GO:0035457)3.07064209
45positive regulation of NF-kappaB import into nucleus (GO:0042346)3.04998637
46cellular response to thyroid hormone stimulus (GO:0097067)3.04743488
47eosinophil chemotaxis (GO:0048245)3.04236638
48positive regulation of macrophage cytokine production (GO:0060907)3.04020525
49negative regulation of fatty acid transport (GO:2000192)3.02599598
50positive regulation of endothelial cell differentiation (GO:0045603)3.01869629
51glycosphingolipid catabolic process (GO:0046479)3.01832891
52regulation of fever generation (GO:0031620)2.99901663
53oligosaccharide catabolic process (GO:0009313)2.98109639
54negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.97109073
55virion attachment to host cell (GO:0019062)2.96676613
56adhesion of symbiont to host cell (GO:0044650)2.96676613
57monocyte chemotaxis (GO:0002548)2.94467510
58regulation of T-helper 2 cell differentiation (GO:0045628)2.91442719
59hydrogen peroxide biosynthetic process (GO:0050665)2.91022601
60defense response to protozoan (GO:0042832)2.90801704
61response to protozoan (GO:0001562)2.89995467
62regulation of endothelial cell differentiation (GO:0045601)2.89543032
63positive regulation of nitric oxide biosynthetic process (GO:0045429)2.88427456
64positive regulation of cellular amide metabolic process (GO:0034250)2.87916070
65negative regulation of lipid storage (GO:0010888)2.87264572
66positive regulation of interferon-alpha production (GO:0032727)2.85441216
67peptide catabolic process (GO:0043171)2.83965667
68regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.81580805
69regulation of podosome assembly (GO:0071801)2.80557662
70positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.79869317
71branching involved in labyrinthine layer morphogenesis (GO:0060670)2.79834938
72detection of molecule of bacterial origin (GO:0032490)2.79415651
73branching involved in salivary gland morphogenesis (GO:0060445)2.79293445
74cellular response to lipopolysaccharide (GO:0071222)2.78147604
75macrophage activation involved in immune response (GO:0002281)2.77227244
76dendritic cell differentiation (GO:0097028)2.76067348
77lipopolysaccharide-mediated signaling pathway (GO:0031663)2.75685679
78hemidesmosome assembly (GO:0031581)2.75059044
79morphogenesis of an endothelium (GO:0003159)2.74878951
80endothelial tube morphogenesis (GO:0061154)2.74878951
81granulocyte activation (GO:0036230)2.74853052
82regulation of phospholipid biosynthetic process (GO:0071071)2.74805971
83hyaluronan catabolic process (GO:0030214)2.73862904
84reactive oxygen species biosynthetic process (GO:1903409)2.73693863
85immunoglobulin mediated immune response (GO:0016064)2.73438806
86response to interferon-alpha (GO:0035455)2.73239769
87positive regulation of p38MAPK cascade (GO:1900745)2.72210407
88negative regulation of cytokine production involved in immune response (GO:0002719)2.71722446
89regulation of type 2 immune response (GO:0002828)2.71435615
90positive regulation of T-helper cell differentiation (GO:0045624)2.71048249
91keratan sulfate catabolic process (GO:0042340)2.70817521
92glycolipid catabolic process (GO:0019377)2.70750174
93regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.69927153
94response to type I interferon (GO:0034340)2.69431683
95cellular response to reactive nitrogen species (GO:1902170)2.68620464
96cellular response to molecule of bacterial origin (GO:0071219)2.68526626
97regulation of interferon-alpha production (GO:0032647)2.68131728
98brown fat cell differentiation (GO:0050873)2.68062127
99eosinophil migration (GO:0072677)2.67600403
100regulation of interleukin-12 production (GO:0032655)2.66696419
101epithelial cell differentiation involved in prostate gland development (GO:0060742)2.66155517
102germinal center formation (GO:0002467)2.66120875
103cellular response to type I interferon (GO:0071357)2.65532252
104type I interferon signaling pathway (GO:0060337)2.65532252
105regulation of antigen processing and presentation (GO:0002577)2.64819426
106myeloid dendritic cell activation (GO:0001773)2.64262715
107positive regulation of natural killer cell activation (GO:0032816)2.62943825
108adhesion of symbiont to host (GO:0044406)2.62908046
109regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.62643462
110neutrophil activation (GO:0042119)2.62405103
111lymphocyte chemotaxis (GO:0048247)2.62024261
112regulation of immunoglobulin secretion (GO:0051023)2.61667114
113response to host immune response (GO:0052572)2.61569540
114response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.61569540
115positive regulation of phagocytosis (GO:0050766)2.61321438
116positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.61230081
117positive regulation of type 2 immune response (GO:0002830)2.60301829
118negative regulation of response to reactive oxygen species (GO:1901032)2.60002942
119sodium-independent organic anion transport (GO:0043252)2.59672203
120cellular response to interferon-gamma (GO:0071346)2.59398846
121positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.59392786
122positive regulation of interleukin-6 production (GO:0032755)2.58758875
123positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.58381269
124response to manganese ion (GO:0010042)2.58305575
125decidualization (GO:0046697)2.58068429
126pinocytosis (GO:0006907)2.55010857
127respiratory burst (GO:0045730)2.54786094
128regulation of interleukin-8 biosynthetic process (GO:0045414)2.54491549
129regulation of monocyte chemotaxis (GO:0090025)2.54441441
130amino sugar catabolic process (GO:0046348)2.53175135
131positive regulation of acute inflammatory response (GO:0002675)2.52864989
132regulation of interferon-beta biosynthetic process (GO:0045357)2.52458563
133wound healing, spreading of epidermal cells (GO:0035313)2.52340378
134regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.51894423
135protein localization to endosome (GO:0036010)2.51789321
136regulation of macrophage cytokine production (GO:0010935)2.51583973
137regulation of phagocytosis (GO:0050764)2.51579806
138sphingosine metabolic process (GO:0006670)2.51174497
139positive regulation of endothelial cell apoptotic process (GO:2000353)2.51140622
140response to interferon-gamma (GO:0034341)2.51029318
141growth hormone receptor signaling pathway (GO:0060396)2.50193616
142regulation of T-helper cell differentiation (GO:0045622)2.49777243
143positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.49512873
144substrate-dependent cell migration (GO:0006929)2.49358561
145response to nitric oxide (GO:0071731)2.48579811
146regulation of mast cell degranulation (GO:0043304)2.48465281
147response to interleukin-6 (GO:0070741)2.45316220
148regulation of chemokine biosynthetic process (GO:0045073)2.45292109
149positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.43084349
150establishment of endothelial barrier (GO:0061028)2.43036376
151interferon-gamma-mediated signaling pathway (GO:0060333)2.41522066
152glomerular visceral epithelial cell development (GO:0072015)2.41346937
153regulation of dendritic cell antigen processing and presentation (GO:0002604)2.40041596
154positive regulation of lipid storage (GO:0010884)2.39776786
155regulation of mononuclear cell migration (GO:0071675)2.39339891
156glomerular epithelial cell development (GO:0072310)2.38870181
157regulation of sequestering of triglyceride (GO:0010889)2.38752957
158neutrophil mediated immunity (GO:0002446)2.38086131
159lipid storage (GO:0019915)2.36192579
160T-helper 1 type immune response (GO:0042088)2.35542162
161positive regulation of natural killer cell differentiation (GO:0032825)2.35107154
162response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.34851391
163response to host defenses (GO:0052200)2.34851391
164surfactant homeostasis (GO:0043129)11.8257656

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.37965790
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.54540324
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.29311389
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.18292241
5GATA1_22025678_ChIP-Seq_K562_Human3.25811596
6TRIM28_21343339_ChIP-Seq_HEK293_Human3.22772777
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.09081454
8Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.90744494
9IRF8_27001747_Chip-Seq_BMDM_Mouse2.78914518
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.78749027
11* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.59301692
12RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.54087205
13RARG_19884340_ChIP-ChIP_MEFs_Mouse2.48163052
14* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.41639344
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.37466023
16CLOCK_20551151_ChIP-Seq_293T_Human2.34468767
17TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.30161760
18STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.27336202
19TP63_17297297_ChIP-ChIP_HaCaT_Human2.24388812
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.20644635
21STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.15631855
22GATA2_21666600_ChIP-Seq_HMVEC_Human2.00713033
23NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.98806539
24SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.96435372
25FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.96236216
26THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.91125418
27CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.82026140
28IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.76337960
29SOX2_20726797_ChIP-Seq_SW620_Human1.75837674
30TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.72529473
31STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.70952562
32ESR2_21235772_ChIP-Seq_MCF-7_Human1.66404981
33STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.61432284
34MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.61189940
35ESR1_21235772_ChIP-Seq_MCF-7_Human1.59020929
36TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.58306270
37PPAR_26484153_Chip-Seq_NCI-H1993_Human1.56365208
38LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.55361588
39PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.53037763
40STAT4_19710469_ChIP-ChIP_TH1__Mouse1.49936898
41RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.47357820
42CDX2_20551321_ChIP-Seq_CACO-2_Human1.45985473
43ESR1_20079471_ChIP-ChIP_T-47D_Human1.45125334
44STAT6_21828071_ChIP-Seq_BEAS2B_Human1.44367448
45FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.42817539
46TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41415486
47* CJUN_26792858_Chip-Seq_BT549_Human1.40981232
48HIF1A_21447827_ChIP-Seq_MCF-7_Human1.40975675
49LXR_22158963_ChIP-Seq_LIVER_Mouse1.38109175
50CDX2_19796622_ChIP-Seq_MESCs_Mouse1.37199370
51CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.36885107
52* VDR_24787735_ChIP-Seq_THP-1_Human1.36800354
53* VDR_24763502_ChIP-Seq_THP-1_Human1.35088493
54FOXO3_23340844_ChIP-Seq_DLD1_Human1.34932297
55CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.33793416
56* BRD4_25478319_ChIP-Seq_HGPS_Human1.33556000
57BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.33451078
58SALL4_18804426_ChIP-ChIP_XEN_Mouse1.32513671
59SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.32017382
60SOX2_27498859_Chip-Seq_STOMACH_Mouse1.30817317
61* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.30166097
62* SPI1_23127762_ChIP-Seq_K562_Human1.29220676
63SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.28934121
64SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.28934121
65KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.27988294
66JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.27688216
67VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.25946036
68SPI1_23547873_ChIP-Seq_NB4_Human1.23660904
69SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.21253920
70* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.20475727
71ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.18350426
72* GATA4_25053715_ChIP-Seq_YYC3_Human1.18032761
73LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.16641406
74ELK3_25401928_ChIP-Seq_HUVEC_Human1.16262442
75NRF2_20460467_ChIP-Seq_MEFs_Mouse1.15681940
76NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.15681940
77PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11668919
78TBX20_22328084_ChIP-Seq_HEART_Mouse1.10215642
79TBX20_22080862_ChIP-Seq_HEART_Mouse1.10215642
80JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09718508
81MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.09708277
82* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.08115879
83RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.06061855
84RACK7_27058665_Chip-Seq_MCF-7_Human1.06025085
85GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.05832888
86* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05444178
87TP53_18474530_ChIP-ChIP_U2OS_Human1.04546988
88PPARA_22158963_ChIP-Seq_LIVER_Mouse1.04147575
89TFEB_21752829_ChIP-Seq_HELA_Human1.03340227
90ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.03309637
91NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.02941450
92GATA1_19941826_ChIP-Seq_K562_Human1.01745174
93RUNX1_22412390_ChIP-Seq_EML_Mouse1.01617937
94RXR_22158963_ChIP-Seq_LIVER_Mouse1.01525022
95* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99898598
96* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.99699343
97AHR_22903824_ChIP-Seq_MCF-7_Human0.99491107
98ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99142292
99* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.98651059
100* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97753471
101ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.97295666
102KDM2B_26808549_Chip-Seq_SUP-B15_Human0.97159149
103PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95494108
104* UBF1/2_26484160_Chip-Seq_HMECs_Human0.95219921
105E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.94329527
106* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92715703
107RUNX_20019798_ChIP-Seq_JUKART_Human0.92652153
108MYB_26560356_Chip-Seq_TH2_Human0.92073728
109NFIB_24661679_ChIP-Seq_LUNG_Mouse0.91723209
110RUNX1_27514584_Chip-Seq_MCF-7_Human0.91639481
111MAF_26560356_Chip-Seq_TH1_Human0.89212788
112FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.88932569
113SMAD_19615063_ChIP-ChIP_OVARY_Human0.88542873
114SMC1_22415368_ChIP-Seq_MEFs_Mouse0.87919004
115VDR_21846776_ChIP-Seq_THP-1_Human0.87024977
116SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86323651
117PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.85583572
118STAT1_20625510_ChIP-Seq_HELA_Human0.85573115
119* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85552250
120SCL_19346495_ChIP-Seq_HPC-7_Human0.85434865
121TP53_16413492_ChIP-PET_HCT116_Human0.85267885
122GATA3_24758297_ChIP-Seq_MCF-7_Human0.83710468
123SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83688341
124* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83176409
125NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.83084659
126GATA1_19941827_ChIP-Seq_MEL_Mouse0.82904041
127PU_27001747_Chip-Seq_BMDM_Mouse0.82588031
128KLF5_25053715_ChIP-Seq_YYC3_Human0.82473147

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004782_abnormal_surfactant_physiolog7.29222260
2MP0001958_emphysema4.26482161
3MP0003724_increased_susceptibility_to4.07194392
4MP0008004_abnormal_stomach_pH2.88021842
5MP0005083_abnormal_biliary_tract2.75019592
6MP0008438_abnormal_cutaneous_collagen2.62020715
7MP0003436_decreased_susceptibility_to2.60943938
8MP0003191_abnormal_cellular_cholesterol2.60560308
9MP0005058_abnormal_lysosome_morphology2.46596027
10MP0008995_early_reproductive_senescence2.40006901
11MP0001835_abnormal_antigen_presentation2.39718609
12MP0003303_peritoneal_inflammation2.31486131
13MP0002295_abnormal_pulmonary_circulatio2.25717657
14MP0001542_abnormal_bone_strength2.22651496
15MP0009785_altered_susceptibility_to2.20962938
16MP0005388_respiratory_system_phenotype2.11219744
17MP0002133_abnormal_respiratory_system2.11219744
18MP0002139_abnormal_hepatobiliary_system1.99826960
19MP0001177_atelectasis1.97727363
20MP0000343_altered_response_to1.94250219
21MP0005275_abnormal_skin_tensile1.84334100
22MP0002254_reproductive_system_inflammat1.83768689
23MP0005167_abnormal_blood-brain_barrier1.80745932
24MP0002148_abnormal_hypersensitivity_rea1.78375230
25MP0005671_abnormal_response_to1.75988468
26MP0005025_abnormal_response_to1.75483234
27MP0002419_abnormal_innate_immunity1.75378587
28MP0001533_abnormal_skeleton_physiology1.67592594
29MP0001790_abnormal_immune_system1.66553259
30MP0005387_immune_system_phenotype1.66553259
31MP0010368_abnormal_lymphatic_system1.66071626
32MP0005164_abnormal_response_to1.60829429
33MP0000685_abnormal_immune_system1.59579916
34MP0003566_abnormal_cell_adhesion1.56880396
35MP0003448_altered_tumor_morphology1.53880500
36MP0004272_abnormal_basement_membrane1.49328908
37MP0004185_abnormal_adipocyte_glucose1.46777397
38MP0005451_abnormal_body_composition1.46720232
39MP0002405_respiratory_system_inflammati1.44597353
40MP0002138_abnormal_hepatobiliary_system1.40416375
41MP0005000_abnormal_immune_tolerance1.39091811
42MP0003075_altered_response_to1.38267382
43MP0005076_abnormal_cell_differentiation1.36123658
44MP0006082_CNS_inflammation1.35916585
45MP0004130_abnormal_muscle_cell1.35399692
46MP0003705_abnormal_hypodermis_morpholog1.34967247
47MP0001851_eye_inflammation1.33273471
48MP0005503_abnormal_tendon_morphology1.31272960
49MP0001879_abnormal_lymphatic_vessel1.30345701
50MP0002277_abnormal_respiratory_mucosa1.25441772
51MP0009764_decreased_sensitivity_to1.21315658
52MP0005023_abnormal_wound_healing1.20207638
53MP0004947_skin_inflammation1.19175606
54MP0009840_abnormal_foam_cell1.18460338
55MP0002332_abnormal_exercise_endurance1.18429125
56MP0004510_myositis1.17987035
57MP0002998_abnormal_bone_remodeling1.17929276
58MP0003186_abnormal_redox_activity1.16912562
59MP0005166_decreased_susceptibility_to1.14918118
60MP0005310_abnormal_salivary_gland1.14084848
61MP0002452_abnormal_antigen_presenting1.11555309
62MP0004883_abnormal_blood_vessel1.11499566
63MP0003279_aneurysm1.10412128
64MP0005595_abnormal_vascular_smooth1.09389120
65MP0005464_abnormal_platelet_physiology1.08700435
66MP0003195_calcinosis1.07868753
67MP0001175_abnormal_lung_morphology1.07469064
68MP0000249_abnormal_blood_vessel1.07255151
69MP0001845_abnormal_inflammatory_respons1.04331503
70MP0003828_pulmonary_edema1.03260096
71MP0005165_increased_susceptibility_to1.02654575
72MP0010155_abnormal_intestine_physiology1.01989153
73MP0000858_altered_metastatic_potential1.01888628
74MP0002933_joint_inflammation1.00961668
75MP0002723_abnormal_immune_serum1.00960392
76MP0005257_abnormal_intraocular_pressure0.99789374
77MP0005666_abnormal_adipose_tissue0.98207296
78MP0008469_abnormal_protein_level0.97670621
79MP0010234_abnormal_vibrissa_follicle0.97421676
80MP0003690_abnormal_glial_cell0.97388103
81MP0001545_abnormal_hematopoietic_system0.96416997
82MP0005397_hematopoietic_system_phenotyp0.96416997
83MP0003795_abnormal_bone_structure0.94863055
84MP0003300_gastrointestinal_ulcer0.94829978
85MP0003656_abnormal_erythrocyte_physiolo0.93946105
86MP0009333_abnormal_splenocyte_physiolog0.93593663
87MP0004858_abnormal_nervous_system0.90866231
88MP0009278_abnormal_bone_marrow0.90857479
89MP0003453_abnormal_keratinocyte_physiol0.90292540
90MP0001819_abnormal_immune_cell0.89099557
91MP0000604_amyloidosis0.88234195
92MP0002420_abnormal_adaptive_immunity0.86744478
93MP0010329_abnormal_lipoprotein_level0.86389371
94MP0003091_abnormal_cell_migration0.85961399
95MP0009763_increased_sensitivity_to0.85930120
96MP0010352_gastrointestinal_tract_polyps0.85828961
97MP0005670_abnormal_white_adipose0.84614758
98MP0002118_abnormal_lipid_homeostasis0.84448917
99MP0000566_synostosis0.84113154
100MP0000716_abnormal_immune_system0.83826311
101MP0003950_abnormal_plasma_membrane0.83545198
102MP0000920_abnormal_myelination0.82410976
103MP0003806_abnormal_nucleotide_metabolis0.82168306
104MP0001881_abnormal_mammary_gland0.82092208
105MP0006054_spinal_hemorrhage0.82028335
106MP0001853_heart_inflammation0.81748236
107MP0000627_abnormal_mammary_gland0.81602871
108MP0009384_cardiac_valve_regurgitation0.81522735
109MP0002006_tumorigenesis0.80921136
110MP0005375_adipose_tissue_phenotype0.80668159
111MP0002896_abnormal_bone_mineralization0.80507291
112MP0002166_altered_tumor_susceptibility0.79830035
113MP0001800_abnormal_humoral_immune0.79720008
114MP0003172_abnormal_lysosome_physiology0.79477666
115MP0001243_abnormal_dermal_layer0.78135507
116MP0000767_abnormal_smooth_muscle0.77427534
117MP0005508_abnormal_skeleton_morphology0.77331613
118MP0003045_fibrosis0.77146881
119MP0003183_abnormal_peptide_metabolism0.77120076
120MP0002132_abnormal_respiratory_system0.76336287
121MP0010386_abnormal_urinary_bladder0.74377677
122MP0009115_abnormal_fat_cell0.73438189
123MP0003329_amyloid_beta_deposits0.69725195
124MP0002060_abnormal_skin_morphology0.69609687
125MP0002877_abnormal_melanocyte_morpholog0.69540095
126MP0005390_skeleton_phenotype0.68800365
127MP0001663_abnormal_digestive_system0.68557733
128MP0005647_abnormal_sex_gland0.64841700
129MP0008874_decreased_physiological_sensi0.62992304
130MP0002429_abnormal_blood_cell0.61187241

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of liposaccharide metabolism (HP:0010968)7.11825639
2Abnormality of glycosphingolipid metabolism (HP:0004343)7.11825639
3Abnormality of glycolipid metabolism (HP:0010969)7.11825639
4Tubulointerstitial fibrosis (HP:0005576)5.23781644
5Eczematoid dermatitis (HP:0000976)5.04856226
6Recurrent abscess formation (HP:0002722)4.57755815
7Tachypnea (HP:0002789)4.51222655
8Respiratory distress (HP:0002098)4.33796462
9Recurrent gram-negative bacterial infections (HP:0005420)4.26102400
10Abnormality of mucopolysaccharide metabolism (HP:0011020)4.08443885
11Abnormality of polysaccharide metabolism (HP:0011012)4.08443885
12Abnormality of glycosaminoglycan metabolism (HP:0004371)4.08443885
13Abnormality of macrophages (HP:0004311)4.06992087
14Recurrent bacterial skin infections (HP:0005406)3.97100611
15Protrusio acetabuli (HP:0003179)3.43377389
16Osteolytic defects of the phalanges of the hand (HP:0009771)3.43369363
17Osteolytic defects of the hand bones (HP:0009699)3.43369363
18Hyperactive renin-angiotensin system (HP:0000841)3.33227578
19Chronic otitis media (HP:0000389)3.28429256
20Autoimmune thrombocytopenia (HP:0001973)3.26488055
21Neurofibrillary tangles (HP:0002185)3.26143952
22Disinhibition (HP:0000734)3.25396816
23Hematochezia (HP:0002573)3.21560965
24Spondylolisthesis (HP:0003302)3.10048577
25Renal salt wasting (HP:0000127)3.09205932
26Vertebral compression fractures (HP:0002953)3.05428284
27Tubulointerstitial abnormality (HP:0001969)2.95881370
28Ulnar bowing (HP:0003031)2.94213813
29Nuclear cataract (HP:0100018)2.93575147
30Elevated erythrocyte sedimentation rate (HP:0003565)2.92485099
31Loss of speech (HP:0002371)2.92482562
32Gout (HP:0001997)2.88779594
33Glomerulonephritis (HP:0000099)2.86666411
34Systemic lupus erythematosus (HP:0002725)2.85784425
35Broad metatarsal (HP:0001783)2.85624686
36Abnormality of the nasal mucosa (HP:0000433)2.80767529
37Mediastinal lymphadenopathy (HP:0100721)2.78574925
38Gingivitis (HP:0000230)2.77869203
39Orchitis (HP:0100796)2.76817646
40Polycythemia (HP:0001901)2.75483478
41Cervical subluxation (HP:0003308)2.72642191
42Chronic bronchitis (HP:0004469)2.67906872
43Onycholysis (HP:0001806)2.66636146
44Cerebral aneurysm (HP:0004944)2.66084853
45Increased cerebral lipofuscin (HP:0011813)2.64027197
46Aortic aneurysm (HP:0004942)2.63537465
47Abnormality of the vasculature of the conjunctiva (HP:0008054)2.62389086
48Myositis (HP:0100614)2.56545826
49Cerebral inclusion bodies (HP:0100314)2.51616447
50Stomach cancer (HP:0012126)2.50925629
51Thick nail (HP:0001805)2.50042996
52Pustule (HP:0200039)2.47709182
53Thyroid-stimulating hormone excess (HP:0002925)2.47560552
54Amyloidosis (HP:0011034)2.47177441
55Stomatitis (HP:0010280)2.45380744
56Atrophic scars (HP:0001075)2.43366804
57Periodontitis (HP:0000704)2.43043634
58Vascular tortuosity (HP:0004948)2.42780183
59Spontaneous hematomas (HP:0007420)2.41830570
60Tubulointerstitial nephritis (HP:0001970)2.40178521
61Progressive neurologic deterioration (HP:0002344)2.39566381
62Peritonitis (HP:0002586)2.38601034
63Increased neuronal autofluorescent lipopigment (HP:0002074)2.37566473
64Mutism (HP:0002300)2.36848152
65Purpura (HP:0000979)2.35994914
66Ovoid vertebral bodies (HP:0003300)2.35989120
67Aortic dissection (HP:0002647)2.30926255
68Acanthosis nigricans (HP:0000956)2.27479405
69Subacute progressive viral hepatitis (HP:0006572)2.24401579
70Axonal loss (HP:0003447)2.23036352
71Asymmetric septal hypertrophy (HP:0001670)2.22691007
72Increased serum ferritin (HP:0003281)2.19695614
73Tetraparesis (HP:0002273)2.19515714
74Apathy (HP:0000741)2.19268137
75Nephritis (HP:0000123)2.18964498
76Keratoconjunctivitis sicca (HP:0001097)2.18271843
77Hemoptysis (HP:0002105)2.17865268
78Tubular atrophy (HP:0000092)2.15454634
79Esophageal varix (HP:0002040)2.14675234
80Emphysema (HP:0002097)2.14556275
81Diminished motivation (HP:0000745)2.14375743
82Long toe (HP:0010511)2.13889918
83Osteomyelitis (HP:0002754)2.13212682
84Joint stiffness (HP:0001387)2.12695459
85Thoracolumbar scoliosis (HP:0002944)2.11318202
86Recurrent skin infections (HP:0001581)2.11038561
87Hyperkalemia (HP:0002153)2.10270116
88Vacuolated lymphocytes (HP:0001922)2.09588740
89Neonatal respiratory distress (HP:0002643)2.06978794
90Bowed forearm bones (HP:0003956)2.05951842
91Bowing of the arm (HP:0006488)2.05951842
92Shallow orbits (HP:0000586)2.05332114
93Abnormality of the pericardium (HP:0001697)2.03260124
94Metaphyseal irregularity (HP:0003025)2.03010212
95Retrobulbar optic neuritis (HP:0100654)2.01817104
96Optic neuritis (HP:0100653)2.01817104
97Prolonged neonatal jaundice (HP:0006579)2.01625281
98Flared iliac wings (HP:0002869)2.01355556
99Keratoconjunctivitis (HP:0001096)2.00994948
100Hepatosplenomegaly (HP:0001433)2.00420337
101Interstitial pulmonary disease (HP:0006530)11.3300328
102Conjunctival telangiectasia (HP:0000524)1.99381876
103Pulmonary hypertension (HP:0002092)1.97737264
104Dilatation of the ascending aorta (HP:0005111)1.97695644
105Basal ganglia calcification (HP:0002135)1.97435290
106J-shaped sella turcica (HP:0002680)1.95889000
107Supranuclear gaze palsy (HP:0000605)1.95081692
108Hypergammaglobulinemia (HP:0010702)1.93217517
109Ankle contracture (HP:0006466)1.93127998
110Complement deficiency (HP:0004431)1.92716016
111Visceral angiomatosis (HP:0100761)1.92702118
112Myocardial infarction (HP:0001658)1.92328699
113Dysostosis multiplex (HP:0000943)1.92109345
114Follicular hyperkeratosis (HP:0007502)1.91914992
115Arterial tortuosity (HP:0005116)1.91298844
116Increased IgM level (HP:0003496)1.89847897
117Micronodular cirrhosis (HP:0001413)1.89724122
118Nasal polyposis (HP:0100582)1.89179596
119Wormian bones (HP:0002645)1.86860747
120Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.86593721
121Pulmonary infiltrates (HP:0002113)1.86432201
122Chronic obstructive pulmonary disease (HP:0006510)1.83681165
123Obstructive lung disease (HP:0006536)1.83681165
124Restrictive lung disease (HP:0002091)1.82915661
125Hemangiomatosis (HP:0007461)1.82548489
126Petechiae (HP:0000967)1.81547148
127Plantar hyperkeratosis (HP:0007556)1.81135511
128Abnormality of proline metabolism (HP:0010907)1.80400323
129Hydroxyprolinuria (HP:0003080)1.80400323
130Growth hormone excess (HP:0000845)1.80395586
131Recurrent fungal infections (HP:0002841)1.79693182
132Soft skin (HP:0000977)1.79383330
133Blue sclerae (HP:0000592)1.78827948
134Abnormality of complement system (HP:0005339)1.78803144
135Turricephaly (HP:0000262)1.78601607
136Thin bony cortex (HP:0002753)1.77954710
137Protuberant abdomen (HP:0001538)1.77821687
138Vasculitis (HP:0002633)1.76886562
139Milia (HP:0001056)1.76482104
140Abnormality of the lumbar spine (HP:0100712)1.75926918
141Abnormality of iron homeostasis (HP:0011031)1.75155083
142Premature rupture of membranes (HP:0001788)1.74579684
143Bronchitis (HP:0012387)1.74526116
144Bladder diverticulum (HP:0000015)1.73236552
145Inappropriate behavior (HP:0000719)1.72630152
146Aortic regurgitation (HP:0001659)1.72208541
147Albinism (HP:0001022)1.71927223
148Mucopolysacchariduria (HP:0008155)1.71796485
149Urinary glycosaminoglycan excretion (HP:0003541)1.71796485
150Hemorrhage of the eye (HP:0011885)1.71389279
151Abnormality of purine metabolism (HP:0004352)1.70276523
152Cellulitis (HP:0100658)1.69531586
153Gastrointestinal infarctions (HP:0005244)1.69530209
154Abnormality of chloride homeostasis (HP:0011422)1.69197383
155Fragile nails (HP:0001808)1.68134903
156Bone pain (HP:0002653)1.67957036
157Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.67639911
158Hypertriglyceridemia (HP:0002155)1.66746918
159Xerostomia (HP:0000217)1.64862405

Predicted kinase interactions (KEA)

RankGene SetZ-score
1GRK73.31725939
2ERN13.14930876
3TRIB32.91733835
4ZAP702.81514114
5STK242.79358416
6FGFR22.64425306
7NME22.64111235
8RIPK12.61912541
9EPHB12.50841606
10LRRK22.35563692
11TAOK22.26566322
12CAMK1D2.25746222
13IRAK32.22859125
14ADRBK22.18925743
15TGFBR22.12171606
16TYK22.11111784
17MST1R2.05347944
18TBK11.94165976
19CDC42BPA1.92287611
20MAP3K141.91140977
21TIE11.89241652
22RIPK41.80854568
23IRAK41.79134512
24MST41.70240034
25MAP3K31.69695611
26BMPR21.63456447
27FGFR41.63122715
28BLK1.61377528
29PDGFRB1.58691053
30JAK11.57624368
31JAK31.53744829
32DAPK21.53469109
33PAK41.52506770
34MOS1.50918210
35FGFR31.49144815
36IKBKE1.48855928
37CAMK1G1.46485590
38CSK1.42904026
39EPHA31.41610894
40EPHB21.41430192
41TESK11.38786570
42TAOK31.34410278
43SIK11.33661191
44STK101.30723986
45ILK1.28909509
46PRPF4B1.26635664
47MAP3K111.26096725
48MAP2K31.25080270
49NEK91.22202580
50KIT1.20082750
51PBK1.19942696
52PIM21.18557791
53TAOK11.18043385
54CDK61.17432163
55EPHA21.16498669
56LMTK21.09779847
57MAP3K21.04338759
58MET1.02466943
59BMX1.00844142
60PTK61.00034949
61MAP4K10.98184937
62RPS6KA40.98164611
63PDGFRA0.95327236
64TXK0.95285895
65ACVR1B0.91945155
66LATS20.89460171
67CHUK0.88164537
68MATK0.87264454
69FRK0.83720752
70IKBKB0.81111178
71ARAF0.79445674
72FER0.78261752
73TTN0.77577437
74JAK20.77077032
75GSK3A0.76437591
76MAP3K50.76320905
77EGFR0.73287048
78LYN0.73106485
79ABL20.72202181
80IRAK20.68869519
81DDR20.67786651
82CSF1R0.67398526
83PAK20.66842326
84PRKD20.66456963
85MAP3K10.65988745
86TEC0.64994628
87ABL10.64763709
88STK30.64491331
89LATS10.63327671
90MAPK70.62548042
91IRAK10.59679320
92FGR0.59269278
93MAP3K90.58944879
94AKT30.58933723
95KSR20.58931487
96HIPK20.58928472
97LIMK10.58099632
98MYLK0.56308925
99HCK0.56061858
100CLK10.55130382
101MAP2K10.54656971
102PRKCD0.54238848
103PTK2B0.51887649
104PRKG20.51743238
105NTRK10.51212520
106MAPK40.49755429
107MAPK150.48379847
108PRKD10.48301156
109TRPM70.47744864
110PDPK10.46546618
111MARK30.45371169
112LCK0.45085540
113SYK0.44861466
114DAPK30.43960803
115TYRO30.43740652
116PTK20.42854811
117RPS6KA60.42652769
118PKN20.42309165
119PRKCQ0.42225459
120IGF1R0.41429384
121GRK50.40961090
122BTK0.39737688
123MAP2K20.39277665
124MAPKAPK20.39251259
125INSR0.37375705
126RPS6KL10.37264250
127RPS6KC10.37264250
128MELK0.34497716
129TGFBR10.34314176
130MAP3K130.34042139
131RPS6KA20.33927738
132PIK3CG0.31947864
133ADRBK10.30201791
134CAMKK20.26823944

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051502.64279493
2Malaria_Homo sapiens_hsa051442.57007616
3Leishmaniasis_Homo sapiens_hsa051402.56687910
4Pertussis_Homo sapiens_hsa051332.52766641
5Lysosome_Homo sapiens_hsa041422.47496418
6Phagosome_Homo sapiens_hsa041452.15237272
7Toll-like receptor signaling pathway_Homo sapiens_hsa046202.08474395
8Fatty acid biosynthesis_Homo sapiens_hsa000612.00610104
9Mineral absorption_Homo sapiens_hsa049781.94603389
10Legionellosis_Homo sapiens_hsa051341.93767350
11Rheumatoid arthritis_Homo sapiens_hsa053231.89565178
12Toxoplasmosis_Homo sapiens_hsa051451.77272863
13Tuberculosis_Homo sapiens_hsa051521.76641997
14Caffeine metabolism_Homo sapiens_hsa002321.76380139
15Osteoclast differentiation_Homo sapiens_hsa043801.75607489
16Graft-versus-host disease_Homo sapiens_hsa053321.71892613
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.69534220
18Type I diabetes mellitus_Homo sapiens_hsa049401.68405030
19TNF signaling pathway_Homo sapiens_hsa046681.67488492
20Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.64811436
21AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.62162630
22Leukocyte transendothelial migration_Homo sapiens_hsa046701.61834293
23Salmonella infection_Homo sapiens_hsa051321.60240538
24ECM-receptor interaction_Homo sapiens_hsa045121.60126065
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.54893599
26Amoebiasis_Homo sapiens_hsa051461.54827508
27Influenza A_Homo sapiens_hsa051641.47579900
28Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.46176251
29NOD-like receptor signaling pathway_Homo sapiens_hsa046211.44293519
30Glycosaminoglycan degradation_Homo sapiens_hsa005311.41670995
31Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.30725791
32African trypanosomiasis_Homo sapiens_hsa051431.29365413
33Measles_Homo sapiens_hsa051621.25014918
34Adherens junction_Homo sapiens_hsa045201.22180831
35Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.19995260
36Adipocytokine signaling pathway_Homo sapiens_hsa049201.18039338
37Hepatitis C_Homo sapiens_hsa051601.17327172
38Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.15458452
39Viral myocarditis_Homo sapiens_hsa054161.15359995
40Apoptosis_Homo sapiens_hsa042101.15074445
41RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.14609596
42PPAR signaling pathway_Homo sapiens_hsa033201.11428951
43Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.10608762
44Focal adhesion_Homo sapiens_hsa045101.06218200
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.05085702
46Intestinal immune network for IgA production_Homo sapiens_hsa046721.04043678
47Small cell lung cancer_Homo sapiens_hsa052221.00402056
48Asthma_Homo sapiens_hsa053101.00319134
49Shigellosis_Homo sapiens_hsa051310.99771566
50Antigen processing and presentation_Homo sapiens_hsa046120.99274139
51Hematopoietic cell lineage_Homo sapiens_hsa046400.96882386
52Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.94378340
53Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.90915736
54Proteoglycans in cancer_Homo sapiens_hsa052050.90322469
55B cell receptor signaling pathway_Homo sapiens_hsa046620.90320551
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.89806312
57Chemokine signaling pathway_Homo sapiens_hsa040620.88810363
58Allograft rejection_Homo sapiens_hsa053300.88775119
59Jak-STAT signaling pathway_Homo sapiens_hsa046300.88487259
60Acute myeloid leukemia_Homo sapiens_hsa052210.87732283
61Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.85429154
62Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.82742486
63Renin-angiotensin system_Homo sapiens_hsa046140.82350834
64Platelet activation_Homo sapiens_hsa046110.81882119
65ABC transporters_Homo sapiens_hsa020100.81872223
66Prion diseases_Homo sapiens_hsa050200.81571859
67Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.79204431
68Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.76859527
69Herpes simplex infection_Homo sapiens_hsa051680.74949520
70Chronic myeloid leukemia_Homo sapiens_hsa052200.74874539
71Pancreatic cancer_Homo sapiens_hsa052120.72618760
72Insulin resistance_Homo sapiens_hsa049310.71355680
73Hepatitis B_Homo sapiens_hsa051610.70852635
74Sulfur metabolism_Homo sapiens_hsa009200.69329783
75Complement and coagulation cascades_Homo sapiens_hsa046100.68532448
76Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.66699550
77VEGF signaling pathway_Homo sapiens_hsa043700.66417530
78Regulation of actin cytoskeleton_Homo sapiens_hsa048100.65164316
79Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.64841182
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.64749347
81Bladder cancer_Homo sapiens_hsa052190.63674371
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62955930
83Other glycan degradation_Homo sapiens_hsa005110.58324804
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57701096
85Collecting duct acid secretion_Homo sapiens_hsa049660.53647500
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.53509563
87Prolactin signaling pathway_Homo sapiens_hsa049170.53005394
88Endocytosis_Homo sapiens_hsa041440.52714496
89Vibrio cholerae infection_Homo sapiens_hsa051100.51975377
90Neurotrophin signaling pathway_Homo sapiens_hsa047220.51928687
91Renal cell carcinoma_Homo sapiens_hsa052110.51854190
92Autoimmune thyroid disease_Homo sapiens_hsa053200.50264259
93Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.50113499
94Glycerolipid metabolism_Homo sapiens_hsa005610.48019390
95Primary immunodeficiency_Homo sapiens_hsa053400.46609427
96HIF-1 signaling pathway_Homo sapiens_hsa040660.46563444
97Endometrial cancer_Homo sapiens_hsa052130.44770718
98Glutathione metabolism_Homo sapiens_hsa004800.44721337
99Tight junction_Homo sapiens_hsa045300.44218121
100Rap1 signaling pathway_Homo sapiens_hsa040150.43864015
101Pathways in cancer_Homo sapiens_hsa052000.43584172
102T cell receptor signaling pathway_Homo sapiens_hsa046600.42254995
103Primary bile acid biosynthesis_Homo sapiens_hsa001200.42205607
104Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41913900
105HTLV-I infection_Homo sapiens_hsa051660.41463922
106Epstein-Barr virus infection_Homo sapiens_hsa051690.40996737
107Fatty acid metabolism_Homo sapiens_hsa012120.39423355
108Fatty acid degradation_Homo sapiens_hsa000710.39406075
109Notch signaling pathway_Homo sapiens_hsa043300.37046198
110Dorso-ventral axis formation_Homo sapiens_hsa043200.37035605
111Galactose metabolism_Homo sapiens_hsa000520.36524630
112TGF-beta signaling pathway_Homo sapiens_hsa043500.35954989
113Sphingolipid metabolism_Homo sapiens_hsa006000.35824926
114Transcriptional misregulation in cancer_Homo sapiens_hsa052020.34425074
115Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30428345
116MAPK signaling pathway_Homo sapiens_hsa040100.24580218
117Systemic lupus erythematosus_Homo sapiens_hsa053220.22820059
118Tryptophan metabolism_Homo sapiens_hsa003800.22135970
119Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.20580552
120Type II diabetes mellitus_Homo sapiens_hsa049300.19836277
121PI3K-Akt signaling pathway_Homo sapiens_hsa041510.19304629

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