DRAM2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene binds microtubule-associated protein 1 light chain 3 and is required for autophagy. Defects in this gene are a cause of retinal dystrophy. In addition, two microRNAs (microRNA 125b-1 and microRNA 144) can bind to the mRNA of this gene and produce the disease state. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)5.18003941
2immunoglobulin mediated immune response (GO:0016064)4.40644572
3central nervous system myelination (GO:0022010)4.39042290
4axon ensheathment in central nervous system (GO:0032291)4.39042290
5L-phenylalanine catabolic process (GO:0006559)4.38778886
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.38778886
7L-phenylalanine metabolic process (GO:0006558)3.88444720
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.88444720
9aldehyde catabolic process (GO:0046185)3.82198091
10cholesterol biosynthetic process (GO:0006695)3.76589954
11B cell mediated immunity (GO:0019724)3.76172684
12positive regulation of gamma-delta T cell activation (GO:0046645)3.66516488
13aromatic amino acid family catabolic process (GO:0009074)3.55539271
14response to peptidoglycan (GO:0032494)3.49473369
15very long-chain fatty acid metabolic process (GO:0000038)3.47000621
16regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.45056040
17regulation of B cell receptor signaling pathway (GO:0050855)3.37905158
18long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.37484621
19negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.37397712
20mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.36128688
21nucleotide transmembrane transport (GO:1901679)3.35989537
22positive regulation of mast cell degranulation (GO:0043306)3.32318335
23positive regulation of mast cell activation involved in immune response (GO:0033008)3.32318335
24sterol biosynthetic process (GO:0016126)3.31787980
25positive regulation of mast cell activation (GO:0033005)3.28083459
26glyoxylate metabolic process (GO:0046487)3.27575257
27positive regulation of B cell differentiation (GO:0045579)3.27384540
28interferon-gamma-mediated signaling pathway (GO:0060333)3.26400149
29fatty-acyl-CoA biosynthetic process (GO:0046949)3.24855497
30negative regulation of interleukin-12 production (GO:0032695)3.22025976
31ribosomal small subunit assembly (GO:0000028)3.14903468
32detection of other organism (GO:0098543)3.13920168
33proteasome assembly (GO:0043248)3.11530236
34fatty-acyl-CoA metabolic process (GO:0035337)3.11256290
35neutrophil activation involved in immune response (GO:0002283)3.10431927
36amyloid precursor protein catabolic process (GO:0042987)3.10389645
37positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.07660213
38bile acid biosynthetic process (GO:0006699)3.07364943
39SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.06146832
40cotranslational protein targeting to membrane (GO:0006613)3.02323809
41long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.01636278
42protein targeting to ER (GO:0045047)3.00611201
43detection of bacterium (GO:0016045)2.99929585
44viral transcription (GO:0019083)2.98713873
45oligosaccharide catabolic process (GO:0009313)2.97232527
46fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.92224769
47ATP synthesis coupled proton transport (GO:0015986)2.92067492
48energy coupled proton transport, down electrochemical gradient (GO:0015985)2.92067492
49establishment of protein localization to endoplasmic reticulum (GO:0072599)2.89319858
50acyl-CoA biosynthetic process (GO:0071616)2.88960017
51thioester biosynthetic process (GO:0035384)2.88960017
52purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.88468168
53regulation of cytokine secretion involved in immune response (GO:0002739)2.88158908
54short-chain fatty acid metabolic process (GO:0046459)2.87133505
55protein localization to endoplasmic reticulum (GO:0070972)2.86172916
56positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.85976580
57translational termination (GO:0006415)2.84955075
58regulation of mast cell degranulation (GO:0043304)2.84283819
59cysteine metabolic process (GO:0006534)2.84276552
60amyloid precursor protein metabolic process (GO:0042982)2.84248688
61tryptophan metabolic process (GO:0006568)2.82194925
62modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.81121339
63positive regulation by organism of defense response of other organism involved in symbiotic interact2.81121339
64modulation by symbiont of host immune response (GO:0052553)2.81121339
65positive regulation by symbiont of host defense response (GO:0052509)2.81121339
66modulation by symbiont of host defense response (GO:0052031)2.81121339
67modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.81121339
68acyl-CoA metabolic process (GO:0006637)2.80806895
69thioester metabolic process (GO:0035383)2.80806895
70positive regulation of cellular amine metabolic process (GO:0033240)2.80233325
71tyrosine metabolic process (GO:0006570)2.78953824
72indole-containing compound catabolic process (GO:0042436)2.78709339
73indolalkylamine catabolic process (GO:0046218)2.78709339
74tryptophan catabolic process (GO:0006569)2.78709339
75isoprenoid biosynthetic process (GO:0008299)2.78698186
76plasma lipoprotein particle clearance (GO:0034381)2.78549514
77triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.78170410
78cofactor catabolic process (GO:0051187)2.78128806
79drug transmembrane transport (GO:0006855)2.77708675
80alpha-linolenic acid metabolic process (GO:0036109)2.77314475
81regulation of mast cell activation (GO:0033003)2.77152254
82regulation of antigen processing and presentation (GO:0002577)2.76958695
83cellular ketone body metabolic process (GO:0046950)2.75913065
84cellular response to interferon-gamma (GO:0071346)2.73222853
85antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.70546209
86response to lipoprotein particle (GO:0055094)2.70218263
87regulation of hypersensitivity (GO:0002883)2.69363288
88cell wall macromolecule catabolic process (GO:0016998)2.68653523
89glutathione derivative metabolic process (GO:1901685)2.68480271
90glutathione derivative biosynthetic process (GO:1901687)2.68480271
91glycerophospholipid catabolic process (GO:0046475)2.66618483
92detection of external biotic stimulus (GO:0098581)2.65849880
93positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.65559275
94neutrophil activation (GO:0042119)2.65527502
95response to interferon-beta (GO:0035456)2.65097946
96peptide catabolic process (GO:0043171)2.64711441
97macrophage activation involved in immune response (GO:0002281)2.64387555
98regulation of mast cell activation involved in immune response (GO:0033006)2.63460749
99granulocyte activation (GO:0036230)2.63267608
100fatty acid beta-oxidation (GO:0006635)2.62134031
101regulation of inflammatory response to antigenic stimulus (GO:0002861)2.61779355
102bile acid metabolic process (GO:0008206)2.61079138
103glycosphingolipid catabolic process (GO:0046479)2.60632091
104acetyl-CoA metabolic process (GO:0006084)2.59190775
105fatty acid catabolic process (GO:0009062)2.58622584
106uronic acid metabolic process (GO:0006063)2.58554062
107glucuronate metabolic process (GO:0019585)2.58554062
108response to phenylpropanoid (GO:0080184)2.57966809
109long-chain fatty acid biosynthetic process (GO:0042759)2.57653067
110complement activation, alternative pathway (GO:0006957)2.57357244
111B cell receptor signaling pathway (GO:0050853)2.56810949
112positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.56591642
113adhesion of symbiont to host cell (GO:0044650)2.56189118
114virion attachment to host cell (GO:0019062)2.56189118
115positive regulation of antigen processing and presentation (GO:0002579)2.55169915
116negative regulation of myeloid cell apoptotic process (GO:0033033)2.55116796
117protein carboxylation (GO:0018214)2.54470889
118peptidyl-glutamic acid carboxylation (GO:0017187)2.54470889
119coenzyme catabolic process (GO:0009109)2.54340639
120cholesterol efflux (GO:0033344)2.54301180
121aromatic amino acid family metabolic process (GO:0009072)2.54030883
122creatine metabolic process (GO:0006600)2.53541013
123detection of molecule of bacterial origin (GO:0032490)2.53174349
124opsonization (GO:0008228)2.52267015
125deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.52252296
126histamine secretion (GO:0001821)2.51310638
127response to interferon-gamma (GO:0034341)2.51196122
128amine catabolic process (GO:0009310)2.49746115
129cellular biogenic amine catabolic process (GO:0042402)2.49746115
130myeloid cell activation involved in immune response (GO:0002275)2.49637220
131lipid oxidation (GO:0034440)2.49619291
132fatty acid oxidation (GO:0019395)2.49550167
133T-helper 1 type immune response (GO:0042088)2.49211096
134regulation of cholesterol esterification (GO:0010872)2.48896433
135purine deoxyribonucleotide catabolic process (GO:0009155)2.48716656
136amino sugar catabolic process (GO:0046348)2.48579156
137cellular response to thyroid hormone stimulus (GO:0097067)2.48249568
138Arp2/3 complex-mediated actin nucleation (GO:0034314)2.47227162
139antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.44361598
140oxidative phosphorylation (GO:0006119)2.44109607
141glycolipid catabolic process (GO:0019377)2.43046806
142regulation of T-helper 1 cell differentiation (GO:0045625)2.42708700
143regulation of triglyceride catabolic process (GO:0010896)2.42527974
144platelet dense granule organization (GO:0060155)2.42294442
145respiratory electron transport chain (GO:0022904)2.42057656
146ensheathment of neurons (GO:0007272)2.41653430
147axon ensheathment (GO:0008366)2.41653430
148myelination (GO:0042552)2.41595782
149regulation of B cell differentiation (GO:0045577)2.41192658
150positive regulation of monocyte chemotaxis (GO:0090026)2.41157885
151monocarboxylic acid catabolic process (GO:0072329)2.40383835
152defense response to protozoan (GO:0042832)2.39982610
153mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.39319078
154myeloid dendritic cell activation (GO:0001773)2.39222521
155negative regulation of protein localization to cell surface (GO:2000009)2.38952733
156regulation of tolerance induction (GO:0002643)2.37119385
157ketone body metabolic process (GO:1902224)2.36335365
158positive regulation of triglyceride lipase activity (GO:0061365)2.36247835
159positive regulation of lipoprotein lipase activity (GO:0051006)2.36247835
160adhesion of symbiont to host (GO:0044406)2.35371906
161alkaloid metabolic process (GO:0009820)2.34772900
162fibrinolysis (GO:0042730)2.34712834
163nucleotide transport (GO:0006862)2.34687843
164signal peptide processing (GO:0006465)2.34371539
165indolalkylamine metabolic process (GO:0006586)2.34137193
166electron transport chain (GO:0022900)2.33906632
167regulation of cholesterol metabolic process (GO:0090181)2.33803383
168translational elongation (GO:0006414)2.33609841
169respiratory burst (GO:0045730)2.33539738
170import into cell (GO:0098657)2.32986369
171ethanol metabolic process (GO:0006067)2.32129661
172ethanol oxidation (GO:0006069)2.31180510
173deoxyribose phosphate catabolic process (GO:0046386)2.30265164
174cell wall macromolecule metabolic process (GO:0044036)2.29631018
175translational initiation (GO:0006413)2.29462155
176purine-containing compound salvage (GO:0043101)2.29438832
177sulfur amino acid catabolic process (GO:0000098)2.29207481
178steroid biosynthetic process (GO:0006694)2.28880246
179regulation of activation of Janus kinase activity (GO:0010533)2.28862024
180positive regulation of leukocyte degranulation (GO:0043302)2.28830871
181transcytosis (GO:0045056)2.28791622
182response to hydroperoxide (GO:0033194)2.27902554
183high-density lipoprotein particle remodeling (GO:0034375)2.27469167
184regulation of dendritic cell antigen processing and presentation (GO:0002604)2.27411318
185cellular glucuronidation (GO:0052695)2.26882219
186heme transport (GO:0015886)2.26648276
187pyrimidine-containing compound transmembrane transport (GO:0072531)2.26189705
188ribosomal large subunit biogenesis (GO:0042273)2.25386296
189regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.25010552
190detection of biotic stimulus (GO:0009595)2.24797388
191regulation of gamma-delta T cell activation (GO:0046643)2.24748447
192negative regulation of neurotransmitter secretion (GO:0046929)2.24446936
193response to protozoan (GO:0001562)2.24166704
194cholesterol metabolic process (GO:0008203)2.23232200
195L-ascorbic acid metabolic process (GO:0019852)2.23027606
196regulation of T cell tolerance induction (GO:0002664)2.22873369
197antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.22730721

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.93611842
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.36845392
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.35768654
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.22998122
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.19307296
6EGR1_23403033_ChIP-Seq_LIVER_Mouse3.02383687
7RXR_22158963_ChIP-Seq_LIVER_Mouse2.93375181
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.86587339
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.70257365
10LXR_22158963_ChIP-Seq_LIVER_Mouse2.66363841
11ELK1_19687146_ChIP-ChIP_HELA_Human2.61545392
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.34386890
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.27700484
14SPI1_23547873_ChIP-Seq_NB4_Human2.27309133
15VDR_23849224_ChIP-Seq_CD4+_Human2.24182919
16IRF8_22096565_ChIP-ChIP_GC-B_Human2.22512022
17PPARA_22158963_ChIP-Seq_LIVER_Mouse2.21960933
18FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.20886929
19PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.14193561
20CDX2_19796622_ChIP-Seq_MESCs_Mouse2.09406404
21Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.03572233
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.96174951
23CREB1_15753290_ChIP-ChIP_HEK293T_Human1.94490743
24HOXB4_20404135_ChIP-ChIP_EML_Mouse1.92375122
25GBX2_23144817_ChIP-Seq_PC3_Human1.91056003
26TAF15_26573619_Chip-Seq_HEK293_Human1.90759393
27* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.89585180
28SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.89499430
29MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.84840413
30CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.82708964
31FOXP3_21729870_ChIP-Seq_TREG_Human1.81369474
32NRF2_20460467_ChIP-Seq_MEFs_Mouse1.80109472
33NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.80109472
34SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.77615873
35TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.72894380
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70708176
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.67470725
38SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.66685921
39HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.66028242
40MYB_21317192_ChIP-Seq_ERMYB_Mouse1.64313008
41IRF8_27001747_Chip-Seq_BMDM_Mouse1.63689401
42CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.59688279
43STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.56679490
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55666290
45* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.55019705
46MYB_26560356_Chip-Seq_TH2_Human1.53299759
47FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.52774277
48ZFP57_27257070_Chip-Seq_ESCs_Mouse1.52014798
49POU3F2_20337985_ChIP-ChIP_501MEL_Human1.50386336
50JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.49951672
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.49024994
52ETS1_20019798_ChIP-Seq_JURKAT_Human1.48507137
53VDR_22108803_ChIP-Seq_LS180_Human1.47051945
54SRF_21415370_ChIP-Seq_HL-1_Mouse1.44305777
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.42968735
56SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.40869674
57* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.40230406
58CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.39981724
59ER_23166858_ChIP-Seq_MCF-7_Human1.38665823
60SOX2_20726797_ChIP-Seq_SW620_Human1.38151007
61PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37536334
62TFEB_21752829_ChIP-Seq_HELA_Human1.34785890
63STAT4_19710469_ChIP-ChIP_TH1__Mouse1.34084987
64GATA3_26560356_Chip-Seq_TH2_Human1.34024700
65NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.33958017
66PADI4_21655091_ChIP-ChIP_MCF-7_Human1.32689477
67OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31680614
68PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.31051050
69STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.30417552
70MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.28800366
71GATA2_21666600_ChIP-Seq_HMVEC_Human1.27718423
72TRIM28_21343339_ChIP-Seq_HEK293_Human1.27268453
73HTT_18923047_ChIP-ChIP_STHdh_Human1.26942722
74IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.26441550
75NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.25328066
76MYB_26560356_Chip-Seq_TH1_Human1.22645238
77CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.20624779
78RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.20554136
79E2F4_17652178_ChIP-ChIP_JURKAT_Human1.20488992
80EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.19206229
81DCP1A_22483619_ChIP-Seq_HELA_Human1.17976696
82P300_19829295_ChIP-Seq_ESCs_Human1.16330207
83NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.15800775
84FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.15295281
85SALL4_22934838_ChIP-ChIP_CD34+_Human1.15129787
86WT1_19549856_ChIP-ChIP_CCG9911_Human1.13496574
87NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.12025473
88VDR_24787735_ChIP-Seq_THP-1_Human1.11686795
89IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.09792927
90SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.09124248
91PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07522813
92ESR1_20079471_ChIP-ChIP_T-47D_Human1.07319209
93AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05187202
94CJUN_26792858_Chip-Seq_BT549_Human1.04490217
95ERG_20887958_ChIP-Seq_HPC-7_Mouse1.03657853
96RUNX_20019798_ChIP-Seq_JUKART_Human1.01921487
97GATA3_27048872_Chip-Seq_THYMUS_Human1.00788482
98EWS_26573619_Chip-Seq_HEK293_Human1.00391414
99E2F1_18555785_ChIP-Seq_MESCs_Mouse0.98900614
100EP300_21415370_ChIP-Seq_HL-1_Mouse0.98863091
101PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.97944950
102FOXA1_21572438_ChIP-Seq_LNCaP_Human0.97560181
103CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.97557734
104TAL1_26923725_Chip-Seq_HPCs_Mouse0.97201565
105BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95244474
106MYC_18555785_ChIP-Seq_MESCs_Mouse0.95129263
107ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.94807508
108SUZ12_18555785_Chip-Seq_ESCs_Mouse0.94709620
109ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94457299
110UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94141678
111NFE2_27457419_Chip-Seq_LIVER_Mouse0.93778850
112PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.93496846
113EZH2_27294783_Chip-Seq_NPCs_Mouse0.93050537
114SALL4_18804426_ChIP-ChIP_XEN_Mouse0.93044480
115GATA1_22025678_ChIP-Seq_K562_Human0.92242858
116CMYC_18555785_Chip-Seq_ESCs_Mouse0.92098438
117* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.91856603
118TP53_18474530_ChIP-ChIP_U2OS_Human0.90912108
119CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90363622
120SPI1_23127762_ChIP-Seq_K562_Human0.90305836
121SOX2_19829295_ChIP-Seq_ESCs_Human0.90205421
122NANOG_19829295_ChIP-Seq_ESCs_Human0.90205421
123EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.90145077
124ELF5_23300383_ChIP-Seq_T47D_Human0.90022262
125* NANOG_18555785_Chip-Seq_ESCs_Mouse0.89807905
126PCGF2_27294783_Chip-Seq_ESCs_Mouse0.89559379
127FLI1_27457419_Chip-Seq_LIVER_Mouse0.89131790
128TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.89076929
129TOP2B_26459242_ChIP-Seq_MCF-7_Human0.88273214
130PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88187098
131MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88178991
132HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.88041536
133SOX2_27498859_Chip-Seq_STOMACH_Mouse0.88012544
134RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.87531264
135P300_18555785_Chip-Seq_ESCs_Mouse0.87307713
136SMAD3_21741376_ChIP-Seq_EPCs_Human0.87260720
137* GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.87072881
138P53_22387025_ChIP-Seq_ESCs_Mouse0.87041292
139FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.87002552
140RUNX1_27457419_Chip-Seq_LIVER_Mouse0.86718886
141SMAD_19615063_ChIP-ChIP_OVARY_Human0.86416866
142GATA4_25053715_ChIP-Seq_YYC3_Human0.86331343
143SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.85613403
144* STAT3_18555785_Chip-Seq_ESCs_Mouse0.85350001
145LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.85340014
146SUZ12_27294783_Chip-Seq_NPCs_Mouse0.85089966
147CRX_20693478_ChIP-Seq_RETINA_Mouse0.84669367
148ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.84009600
149ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.82490414
150SMAD1_18555785_Chip-Seq_ESCs_Mouse0.82489339
151MYC_19030024_ChIP-ChIP_MESCs_Mouse0.82462154
152FUS_26573619_Chip-Seq_HEK293_Human0.82350244
153CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.82175305
154FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.82155048
155VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.81854351
156SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.81739429
157BCAT_22108803_ChIP-Seq_LS180_Human0.81597808
158EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.81337766
159E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.81217655
160* RBPJ_21746931_ChIP-Seq_IB4_Human0.80631714
161BMI1_23680149_ChIP-Seq_NPCS_Mouse0.80495495
162FOXM1_26456572_ChIP-Seq_MCF-7_Human0.80457271
163NELFA_20434984_ChIP-Seq_ESCs_Mouse0.80408756
164SOX2_18555785_Chip-Seq_ESCs_Mouse0.80301630
165FOXA1_25329375_ChIP-Seq_VCAP_Human0.79796092
166FOXA1_27270436_Chip-Seq_PROSTATE_Human0.79796092
167MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.79350293
168AR_20517297_ChIP-Seq_VCAP_Human0.79256298
169PU_27001747_Chip-Seq_BMDM_Mouse0.78627871
170* GATA6_21074721_ChIP-Seq_CACO-2_Human0.78255379

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.57930753
2MP0005360_urolithiasis4.03787839
3MP0005085_abnormal_gallbladder_physiolo3.30079791
4MP0003195_calcinosis3.23308420
5MP0008875_abnormal_xenobiotic_pharmacok3.04278351
6MP0005365_abnormal_bile_salt3.02069701
7MP0000920_abnormal_myelination2.71936245
8MP0003806_abnormal_nucleotide_metabolis2.69494214
9MP0003690_abnormal_glial_cell2.64644467
10MP0005058_abnormal_lysosome_morphology2.54003362
11MP0003191_abnormal_cellular_cholesterol2.53425306
12MP0003303_peritoneal_inflammation2.47062333
13MP0001800_abnormal_humoral_immune2.45013490
14MP0003724_increased_susceptibility_to2.42995226
15MP0006054_spinal_hemorrhage2.35918782
16MP0009840_abnormal_foam_cell2.31296680
17MP0000685_abnormal_immune_system2.30177679
18MP0002132_abnormal_respiratory_system2.26082126
19MP0005451_abnormal_body_composition2.17919530
20MP0006082_CNS_inflammation2.17771924
21MP0001666_abnormal_nutrient_absorption2.06047985
22MP0005083_abnormal_biliary_tract2.03506259
23MP0005332_abnormal_amino_acid2.03300437
24MP0002138_abnormal_hepatobiliary_system2.02576840
25MP0002420_abnormal_adaptive_immunity1.94748881
26MP0001819_abnormal_immune_cell1.94522595
27MP0001853_heart_inflammation1.93575714
28MP0003950_abnormal_plasma_membrane1.88708823
29MP0003252_abnormal_bile_duct1.86001478
30MP0003186_abnormal_redox_activity1.79525133
31MP0002148_abnormal_hypersensitivity_rea1.69605962
32MP0010329_abnormal_lipoprotein_level1.69450419
33MP0005408_hypopigmentation1.64591963
34MP0003300_gastrointestinal_ulcer1.64504927
35MP0005075_abnormal_melanosome_morpholog1.61107152
36MP0010155_abnormal_intestine_physiology1.58360821
37MP0002118_abnormal_lipid_homeostasis1.58226062
38MP0009785_altered_susceptibility_to1.56905137
39MP0000604_amyloidosis1.56527680
40MP0004019_abnormal_vitamin_homeostasis1.53490307
41MP0003172_abnormal_lysosome_physiology1.50685899
42MP0002419_abnormal_innate_immunity1.49708735
43MP0009764_decreased_sensitivity_to1.47929500
44MP0004147_increased_porphyrin_level1.46934272
45MP0000716_abnormal_immune_system1.45882232
46MP0002405_respiratory_system_inflammati1.45386824
47MP0005171_absent_coat_pigmentation1.44590120
48MP0004782_abnormal_surfactant_physiolog1.40014622
49MP0000689_abnormal_spleen_morphology1.39072107
50MP0004043_abnormal_pH_regulation1.37091082
51MP0009643_abnormal_urine_homeostasis1.36985264
52MP0009697_abnormal_copulation1.36375836
53MP0005310_abnormal_salivary_gland1.34900880
54MP0001835_abnormal_antigen_presentation1.34744623
55MP0005167_abnormal_blood-brain_barrier1.34250637
56MP0002398_abnormal_bone_marrow1.32967483
57MP0005584_abnormal_enzyme/coenzyme_acti1.32302151
58MP0002277_abnormal_respiratory_mucosa1.31126641
59MP0002295_abnormal_pulmonary_circulatio1.30592756
60MP0002166_altered_tumor_susceptibility1.22378832
61MP0002254_reproductive_system_inflammat1.21826751
62MP0000372_irregular_coat_pigmentation1.19461629
63MP0008260_abnormal_autophagy1.19422018
64MP0001905_abnormal_dopamine_level1.18385848
65MP0008469_abnormal_protein_level1.18085101
66MP0005025_abnormal_response_to1.16693142
67MP0002429_abnormal_blood_cell1.15172772
68MP0005084_abnormal_gallbladder_morpholo1.14657162
69MP0003183_abnormal_peptide_metabolism1.13115228
70MP0002722_abnormal_immune_system1.12893217
71MP0000609_abnormal_liver_physiology1.12621677
72MP0009333_abnormal_splenocyte_physiolog1.12470780
73MP0001879_abnormal_lymphatic_vessel1.10812123
74MP0003656_abnormal_erythrocyte_physiolo1.10483997
75MP0001764_abnormal_homeostasis1.08907017
76MP0000858_altered_metastatic_potential1.07646317
77MP0005000_abnormal_immune_tolerance1.07343176
78MP0003329_amyloid_beta_deposits1.04771599
79MP0005164_abnormal_response_to1.04549689
80MP0005636_abnormal_mineral_homeostasis1.03660112
81MP0001545_abnormal_hematopoietic_system1.03227619
82MP0005397_hematopoietic_system_phenotyp1.03227619
83MP0000465_gastrointestinal_hemorrhage1.02221070
84MP0005387_immune_system_phenotype1.01437334
85MP0001790_abnormal_immune_system1.01437334
86MP0003011_delayed_dark_adaptation1.01113168
87MP0002876_abnormal_thyroid_physiology1.00951141
88MP0010368_abnormal_lymphatic_system0.99684954
89MP0003436_decreased_susceptibility_to0.99077769
90MP0003868_abnormal_feces_composition0.98929800
91MP0008004_abnormal_stomach_pH0.95926200
92MP0000343_altered_response_to0.95018296
93MP0005535_abnormal_body_temperature0.94734861
94MP0005319_abnormal_enzyme/_coenzyme0.93651333
95MP0002006_tumorigenesis0.92926935
96MP0003136_yellow_coat_color0.92752757
97MP0003763_abnormal_thymus_physiology0.92210181
98MP0002837_dystrophic_cardiac_calcinosis0.91936214
99MP0001533_abnormal_skeleton_physiology0.90399882
100MP0008995_early_reproductive_senescence0.88688333
101MP0003634_abnormal_glial_cell0.87110741
102MP0009763_increased_sensitivity_to0.85137569
103MP0003448_altered_tumor_morphology0.84987435
104MP0003786_premature_aging0.83565786
105MP0000230_abnormal_systemic_arterial0.81764504
106MP0004742_abnormal_vestibular_system0.80208259
107MP0001845_abnormal_inflammatory_respons0.79229381
108MP0001661_extended_life_span0.77528132
109MP0001542_abnormal_bone_strength0.77422884
110MP0003075_altered_response_to0.76947341
111MP0002136_abnormal_kidney_physiology0.76122535
112MP0004381_abnormal_hair_follicle0.75449777
113MP0010386_abnormal_urinary_bladder0.75445276
114MP0001756_abnormal_urination0.73594608
115MP0003828_pulmonary_edema0.73484989
116MP0005165_increased_susceptibility_to0.73365942
117MP0005464_abnormal_platelet_physiology0.73188201
118MP0002332_abnormal_exercise_endurance0.72298127
119MP0009765_abnormal_xenobiotic_induced0.71297587
120MP0005379_endocrine/exocrine_gland_phen0.71147148
121MP0005409_darkened_coat_color0.69711300
122MP0002723_abnormal_immune_serum0.69704110
123MP0005166_decreased_susceptibility_to0.69650347
124MP0006036_abnormal_mitochondrial_physio0.69078962
125MP0005647_abnormal_sex_gland0.68609759
126MP0006035_abnormal_mitochondrial_morpho0.68574462
127MP0002163_abnormal_gland_morphology0.68421119
128MP0002998_abnormal_bone_remodeling0.67930926
129MP0000249_abnormal_blood_vessel0.67539283
130MP0004130_abnormal_muscle_cell0.66545858
131MP0005671_abnormal_response_to0.66468809
132MP0002009_preneoplasia0.66147230
133MP0002971_abnormal_brown_adipose0.66082109
134MP0009379_abnormal_foot_pigmentation0.65450291
135MP0002090_abnormal_vision0.65199316
136MP0002229_neurodegeneration0.63059921
137MP0005376_homeostasis/metabolism_phenot0.63034683
138MP0003633_abnormal_nervous_system0.62906875
139MP0004883_abnormal_blood_vessel0.61987169
140MP0002452_abnormal_antigen_presenting0.61201107
141MP0001851_eye_inflammation0.60529958
142MP0009642_abnormal_blood_homeostasis0.59535237

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of liposaccharide metabolism (HP:0010968)3.96475435
2Abnormality of glycosphingolipid metabolism (HP:0004343)3.96475435
3Abnormality of glycolipid metabolism (HP:0010969)3.96475435
4Abnormality of aromatic amino acid family metabolism (HP:0004338)3.90611737
5Intrahepatic cholestasis (HP:0001406)3.74694244
6Neurofibrillary tangles (HP:0002185)3.52862696
7Prolonged partial thromboplastin time (HP:0003645)3.51305387
8Vacuolated lymphocytes (HP:0001922)3.46408774
9Parakeratosis (HP:0001036)3.42220535
10Xanthomatosis (HP:0000991)3.26710908
11Systemic lupus erythematosus (HP:0002725)3.21617165
12Disinhibition (HP:0000734)3.18656377
13Hyperlipoproteinemia (HP:0010980)3.04753585
14Deep venous thrombosis (HP:0002625)2.98567681
15Complement deficiency (HP:0004431)2.97093173
16Nausea (HP:0002018)2.96309142
17Recurrent gram-negative bacterial infections (HP:0005420)2.89882690
18Recurrent sinusitis (HP:0011108)2.84695499
19Axonal loss (HP:0003447)2.82159157
20Abnormality of fatty-acid metabolism (HP:0004359)2.78664287
21Joint hemorrhage (HP:0005261)2.78116024
22Petechiae (HP:0000967)2.73194215
23Cerebral hemorrhage (HP:0001342)2.71799947
24Fat malabsorption (HP:0002630)2.70950918
25Acute encephalopathy (HP:0006846)2.70487573
26Glomerulonephritis (HP:0000099)2.69281392
27Abnormality of glycolysis (HP:0004366)2.67582230
28Increased serum pyruvate (HP:0003542)2.67582230
29Abnormality of aspartate family amino acid metabolism (HP:0010899)2.65891489
30Renal Fanconi syndrome (HP:0001994)2.64739626
31Obstructive lung disease (HP:0006536)2.63865634
32Chronic obstructive pulmonary disease (HP:0006510)2.63865634
33Generalized aminoaciduria (HP:0002909)2.62753461
34Abnormality of urine glucose concentration (HP:0011016)2.61383188
35Glycosuria (HP:0003076)2.61383188
36Recurrent bacterial skin infections (HP:0005406)2.61377451
37Mediastinal lymphadenopathy (HP:0100721)2.61326490
38Vasculitis (HP:0002633)2.58613475
39Conjugated hyperbilirubinemia (HP:0002908)2.57147692
40Steatorrhea (HP:0002570)2.55637644
41Recurrent abscess formation (HP:0002722)2.53131164
42Hepatosplenomegaly (HP:0001433)2.52352299
43Meningitis (HP:0001287)2.51599339
44Abnormality of methionine metabolism (HP:0010901)2.49836087
45Abnormality of macrophages (HP:0004311)2.49276473
46Methylmalonic acidemia (HP:0002912)2.48693893
47Stomatitis (HP:0010280)2.45596434
48Hypobetalipoproteinemia (HP:0003563)2.44176589
49Hypoglycemic coma (HP:0001325)2.43778144
50Cerebral edema (HP:0002181)2.42028675
51Acute necrotizing encephalopathy (HP:0006965)2.41723292
52Degeneration of the lateral corticospinal tracts (HP:0002314)2.41361396
53Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.41361396
54Abnormality of the prostate (HP:0008775)2.39720297
55Increased CSF lactate (HP:0002490)2.37720193
56Gastrointestinal stroma tumor (HP:0100723)2.36783400
57Eczematoid dermatitis (HP:0000976)2.35943114
58Abnormality of monocarboxylic acid metabolism (HP:0010996)2.35199964
59Hepatocellular necrosis (HP:0001404)2.32414731
60Abnormality of glutamine family amino acid metabolism (HP:0010902)2.32258411
61IgM deficiency (HP:0002850)2.31200475
62Abnormality of glycine metabolism (HP:0010895)2.30018760
63Abnormality of serine family amino acid metabolism (HP:0010894)2.30018760
64Ketosis (HP:0001946)2.29177085
65Hyperammonemia (HP:0001987)2.29089393
66Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.29019010
67Hypomagnesemia (HP:0002917)2.28707551
68Dicarboxylic aciduria (HP:0003215)2.28594993
69Abnormality of dicarboxylic acid metabolism (HP:0010995)2.28594993
70Hypokalemic alkalosis (HP:0001949)2.28339181
71Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.27441213
72Macrocytic anemia (HP:0001972)2.27075859
73Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.26521835
74Loss of speech (HP:0002371)2.24164338
75Chronic mucocutaneous candidiasis (HP:0002728)2.24035431
76Recurrent cutaneous fungal infections (HP:0011370)2.24035431
77Metabolic alkalosis (HP:0200114)2.21456356
78Chronic diarrhea (HP:0002028)2.21306153
79Reticulocytopenia (HP:0001896)2.20329812
80Cerebral inclusion bodies (HP:0100314)2.19916922
81Abnormality of renal resorption (HP:0011038)2.19502051
82Recurrent fungal infections (HP:0002841)2.18731736
83Vascular calcification (HP:0004934)2.17132494
84Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.16510239
85Increased cerebral lipofuscin (HP:0011813)2.15033251
86Myositis (HP:0100614)2.15022364
87Optic neuritis (HP:0100653)2.14366223
88Retrobulbar optic neuritis (HP:0100654)2.14366223
89Panhypogammaglobulinemia (HP:0003139)2.14034125
90Agammaglobulinemia (HP:0004432)2.12938431
91Spastic paraparesis (HP:0002313)2.12123992
92Hypophosphatemic rickets (HP:0004912)2.11056787
93Abnormality of complement system (HP:0005339)2.10997492
94Sensory axonal neuropathy (HP:0003390)2.10705438
95Proximal tubulopathy (HP:0000114)2.10616722
96Pulmonary infiltrates (HP:0002113)2.09931773
97Abnormal mitochondria in muscle tissue (HP:0008316)2.09719794
98Methylmalonic aciduria (HP:0012120)2.09271078
99Recurrent skin infections (HP:0001581)2.08709876
100Recurrent bronchitis (HP:0002837)2.08675350
101Congenital ichthyosiform erythroderma (HP:0007431)2.07131774
102Progressive macrocephaly (HP:0004481)2.06345483
103Epidermoid cyst (HP:0200040)2.06291529
104Recurrent viral infections (HP:0004429)2.06086480
105Lethargy (HP:0001254)2.05495640
106Recurrent pneumonia (HP:0006532)2.04883267
107Combined immunodeficiency (HP:0005387)2.04807328
108Hyperglycinuria (HP:0003108)2.03743445
109Malnutrition (HP:0004395)2.02544482
110Lymphopenia (HP:0001888)2.02102704
111Elevated erythrocyte sedimentation rate (HP:0003565)2.01691473
112Increased circulating renin level (HP:0000848)2.01407563
113Hepatic necrosis (HP:0002605)2.00960144
114Alkalosis (HP:0001948)1.99546429
115Mutism (HP:0002300)1.98235117
116Abnormality of purine metabolism (HP:0004352)1.98176424
117Mitochondrial inheritance (HP:0001427)1.97801287
118T lymphocytopenia (HP:0005403)1.97396758
119Abnormality of sulfur amino acid metabolism (HP:0004339)1.97360997
120Prolonged neonatal jaundice (HP:0006579)1.96790622
121Encephalitis (HP:0002383)1.96788324
122Amyloidosis (HP:0011034)1.95328816
123Ketoacidosis (HP:0001993)1.95298546
124Lipid accumulation in hepatocytes (HP:0006561)1.95158231
125Skin rash (HP:0000988)1.94783182
126Hemoptysis (HP:0002105)1.94754395
127Pulmonary fibrosis (HP:0002206)1.94380952
128Hypolipoproteinemia (HP:0010981)1.94380846
129Vomiting (HP:0002013)1.94169900
130Abnormality of the vitamin B12 metabolism (HP:0004341)1.92776497
131Abnormality of the vasculature of the conjunctiva (HP:0008054)1.92652819
132Leukodystrophy (HP:0002415)1.92400112
133Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.92289917
134Abnormality of the common coagulation pathway (HP:0010990)1.90739119
135Dysostosis multiplex (HP:0000943)1.90575576
136Orchitis (HP:0100796)1.89775904
137Hypercholesterolemia (HP:0003124)1.89528234
138Pustule (HP:0200039)1.89074899
139Bronchiectasis (HP:0002110)1.88140411
140Increased neuronal autofluorescent lipopigment (HP:0002074)1.88051720
141Urticaria (HP:0001025)1.87938817
142Neutropenia (HP:0001875)1.87497657
143Respiratory distress (HP:0002098)1.86969502
144Exertional dyspnea (HP:0002875)1.85568235
145Metabolic acidosis (HP:0001942)1.85129591
146Abnormality of T cell number (HP:0011839)1.85028793
147Rhinitis (HP:0012384)1.84182318
148Abnormality of vitamin B metabolism (HP:0004340)1.83832408
149Hyperglycinemia (HP:0002154)1.83602176
150Renal cortical cysts (HP:0000803)1.83451225
151Increased hepatocellular lipid droplets (HP:0006565)1.83150861
152B lymphocytopenia (HP:0010976)1.82957337
153Cardiovascular calcification (HP:0011915)1.82456902
154Polyneuropathy (HP:0001271)1.81221130
155Peripheral demyelination (HP:0011096)1.80647838
156Abolished electroretinogram (ERG) (HP:0000550)1.80067240
157Basal ganglia calcification (HP:0002135)1.79822545
158Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.79715849
1593-Methylglutaconic aciduria (HP:0003535)1.78400342
160Paraparesis (HP:0002385)1.77858718
161Inflammation of the large intestine (HP:0002037)1.77478035
162Purpura (HP:0000979)1.76908732
163Colitis (HP:0002583)1.76384427
164Abnormality of B cell number (HP:0010975)1.76245062
165Hypothermia (HP:0002045)1.76173568
166Respiratory failure (HP:0002878)1.75489118
167Hypoalphalipoproteinemia (HP:0003233)1.74161679

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.38438142
2ACVR1B3.59718225
3PBK3.49134920
4OXSR13.31515027
5EPHB13.20263132
6MST43.02458079
7MAP4K22.45910602
8EIF2AK32.43851662
9MAP4K12.32903124
10TIE12.29618971
11WNK42.29092247
12MAP3K122.28582406
13MAP3K142.24470032
14NME22.22330384
15BCR2.12957220
16NEK12.09769151
17FGFR21.92794677
18TNIK1.88606902
19BLK1.71166162
20INSRR1.69566656
21TRIM281.64071507
22PDK21.63785461
23BMPR1B1.63372879
24IRAK31.62329192
25PKN11.58317590
26CSF1R1.52861506
27IRAK41.51224240
28GRK71.50539659
29BCKDK1.48592406
30MAPKAPK51.43540997
31MATK1.40471764
32CDK191.38021184
33MET1.37720686
34ERBB41.34315652
35PIK3CG1.33922682
36FRK1.33539531
37FES1.27448025
38BMPR21.25225830
39JAK31.23944937
40SYK1.23427350
41TGFBR11.21612964
42TBK11.21551724
43BTK1.19105095
44ZAK1.18644377
45IRAK21.14540398
46PASK1.13914339
47SIK31.11988402
48IRAK11.11845102
49MAPK151.11471028
50CSNK1G31.09913112
51TGFBR21.09585116
52IKBKE1.08162866
53MST1R1.07450937
54FGR1.04569329
55ABL21.04264624
56KDR1.03369386
57NUAK11.03083119
58ERBB31.01597285
59CASK0.99236910
60PRKCQ0.98470411
61CSNK1A1L0.98167132
62CSNK1G10.96961169
63FLT30.94998758
64TAOK30.94492029
65FGFR40.92547059
66TYK20.91517434
67IKBKB0.90887712
68OBSCN0.90492910
69TRPM70.90303104
70RIPK40.89934419
71SGK2230.89099018
72SGK4940.89099018
73WNK10.88448853
74BUB10.88280249
75PRKCE0.88025270
76ADRBK20.87473968
77MKNK10.86511281
78MYLK0.85951175
79GRK10.85729455
80HCK0.82886024
81STK160.82619146
82NEK90.81098700
83CSK0.80986756
84KIT0.80218435
85LIMK10.77909530
86EPHA30.77470498
87NEK60.77203820
88STK240.76447146
89ZAP700.75020881
90GRK60.72912272
91DYRK20.72867431
92CAMK2D0.72391536
93STK100.72333915
94RPS6KA40.71899861
95VRK10.71099479
96PLK40.70364430
97CSNK1G20.69005887
98MAP2K20.68253781
99TEC0.67704918
100NLK0.66854140
101MUSK0.66482764
102ARAF0.66112059
103GSK3A0.65615159
104JAK20.65610891
105PIK3CA0.65271767
106CAMK2B0.63392260
107TXK0.63055024
108ITK0.62420215
109MAP3K130.61540610
110CCNB10.60360800
111DYRK30.59888370
112CAMK2G0.59604924
113PRKAA20.59157171
114NTRK10.58139340
115EIF2AK10.56628786
116CAMKK20.56186043
117LYN0.55793811
118LRRK20.55183922
119CLK10.52080647
120VRK20.51682593
121ABL10.50659597
122CAMK2A0.50420222
123JAK10.49158223
124IGF1R0.48344607
125MKNK20.47907154
126PTK2B0.47381049
127ROCK20.46400713
128WNK30.46097609
129PRKG20.45030795
130LCK0.44843801
131PRKD10.43998890
132PINK10.43897080
133PDPK10.43504078
134PRPF4B0.43471047
135MOS0.42912820
136BRSK20.42628437
137NEK20.42506586
138PRKCD0.42423662
139PRKG10.42167204
140PLK30.42083173
141CHUK0.40952490
142YES10.40637994
143MAP3K50.40607649
144AKT30.39705449
145GRK50.39280948
146CSNK2A10.38983944
147EGFR0.38027335
148MAP3K100.37511716
149MARK30.37328684
150EIF2AK20.36616801
151MAP3K30.36487942
152STK30.35877241
153TNK20.33317912

Predicted pathways (KEGG)

RankGene SetZ-score
1Intestinal immune network for IgA production_Homo sapiens_hsa046723.27837914
2Steroid biosynthesis_Homo sapiens_hsa001003.26963151
3Fatty acid elongation_Homo sapiens_hsa000623.23646801
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.00003718
5Type I diabetes mellitus_Homo sapiens_hsa049402.77178390
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.74582987
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.67616305
8Ribosome_Homo sapiens_hsa030102.48662113
9Primary bile acid biosynthesis_Homo sapiens_hsa001202.46768274
10Histidine metabolism_Homo sapiens_hsa003402.36008517
11Antigen processing and presentation_Homo sapiens_hsa046122.35681505
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.31734492
13Sulfur metabolism_Homo sapiens_hsa009202.22465320
14Proteasome_Homo sapiens_hsa030502.15732020
15Peroxisome_Homo sapiens_hsa041462.11439849
16Staphylococcus aureus infection_Homo sapiens_hsa051502.07854754
17Butanoate metabolism_Homo sapiens_hsa006502.05499041
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.04685461
19Propanoate metabolism_Homo sapiens_hsa006401.99061955
20Fatty acid degradation_Homo sapiens_hsa000711.94121308
21Complement and coagulation cascades_Homo sapiens_hsa046101.91828857
22Tryptophan metabolism_Homo sapiens_hsa003801.89428812
23Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.83408970
24Fatty acid metabolism_Homo sapiens_hsa012121.74230649
25Pentose and glucuronate interconversions_Homo sapiens_hsa000401.72127603
26Primary immunodeficiency_Homo sapiens_hsa053401.66631209
27Oxidative phosphorylation_Homo sapiens_hsa001901.64070613
28Viral myocarditis_Homo sapiens_hsa054161.58501171
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.58475007
30Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.55837373
31Protein export_Homo sapiens_hsa030601.53717413
32Chemical carcinogenesis_Homo sapiens_hsa052041.49195786
33Hematopoietic cell lineage_Homo sapiens_hsa046401.45134065
34PPAR signaling pathway_Homo sapiens_hsa033201.43362203
35beta-Alanine metabolism_Homo sapiens_hsa004101.42481071
36Steroid hormone biosynthesis_Homo sapiens_hsa001401.41040462
37Ether lipid metabolism_Homo sapiens_hsa005651.40651488
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.38945739
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.37472803
40Arginine biosynthesis_Homo sapiens_hsa002201.26594016
41Nitrogen metabolism_Homo sapiens_hsa009101.26542023
42Rheumatoid arthritis_Homo sapiens_hsa053231.22898491
43Vitamin digestion and absorption_Homo sapiens_hsa049771.22194012
44Retinol metabolism_Homo sapiens_hsa008301.20376968
45Arginine and proline metabolism_Homo sapiens_hsa003301.15969250
46Legionellosis_Homo sapiens_hsa051341.15686425
47Lysosome_Homo sapiens_hsa041421.13796262
48Pyruvate metabolism_Homo sapiens_hsa006201.08262962
49Caffeine metabolism_Homo sapiens_hsa002321.06904781
50Tyrosine metabolism_Homo sapiens_hsa003501.06283582
51NF-kappa B signaling pathway_Homo sapiens_hsa040641.05856215
52Glutathione metabolism_Homo sapiens_hsa004801.04668228
53Phenylalanine metabolism_Homo sapiens_hsa003601.03928715
54Sphingolipid metabolism_Homo sapiens_hsa006001.03878802
55Osteoclast differentiation_Homo sapiens_hsa043801.03591800
56NOD-like receptor signaling pathway_Homo sapiens_hsa046211.01941704
57Herpes simplex infection_Homo sapiens_hsa051680.99213141
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.99096915
59Toxoplasmosis_Homo sapiens_hsa051450.98604825
60Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.97769207
61Parkinsons disease_Homo sapiens_hsa050120.97416664
62Folate biosynthesis_Homo sapiens_hsa007900.97086535
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.95542179
64Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.94931045
65alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.94207760
66Maturity onset diabetes of the young_Homo sapiens_hsa049500.94138240
67Linoleic acid metabolism_Homo sapiens_hsa005910.93042680
68Collecting duct acid secretion_Homo sapiens_hsa049660.90057920
69ABC transporters_Homo sapiens_hsa020100.87668647
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.87017626
71Influenza A_Homo sapiens_hsa051640.86939467
72Alzheimers disease_Homo sapiens_hsa050100.86799338
73Phagosome_Homo sapiens_hsa041450.85673946
74Homologous recombination_Homo sapiens_hsa034400.85144616
75Non-homologous end-joining_Homo sapiens_hsa034500.84810153
76Malaria_Homo sapiens_hsa051440.84739352
77Starch and sucrose metabolism_Homo sapiens_hsa005000.84126137
78Fat digestion and absorption_Homo sapiens_hsa049750.82815369
79Arachidonic acid metabolism_Homo sapiens_hsa005900.77913845
80Mismatch repair_Homo sapiens_hsa034300.77150276
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.74760089
82Bile secretion_Homo sapiens_hsa049760.73869370
83Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.73046801
84Systemic lupus erythematosus_Homo sapiens_hsa053220.72751740
85Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.71501043
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.71443691
87Pertussis_Homo sapiens_hsa051330.71439810
88RNA degradation_Homo sapiens_hsa030180.70648355
89Other glycan degradation_Homo sapiens_hsa005110.69725394
90B cell receptor signaling pathway_Homo sapiens_hsa046620.67963751
91Glycerolipid metabolism_Homo sapiens_hsa005610.67386725
92Mineral absorption_Homo sapiens_hsa049780.66414488
93Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.65611965
94Measles_Homo sapiens_hsa051620.64959211
95Graft-versus-host disease_Homo sapiens_hsa053320.62532418
96Basal transcription factors_Homo sapiens_hsa030220.61778676
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61152955
98Vitamin B6 metabolism_Homo sapiens_hsa007500.60527018
99Epstein-Barr virus infection_Homo sapiens_hsa051690.59533165
100Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59139562
101Metabolic pathways_Homo sapiens_hsa011000.59108387
102Fatty acid biosynthesis_Homo sapiens_hsa000610.55196579
103Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.53382191
104Vibrio cholerae infection_Homo sapiens_hsa051100.51660999
105Galactose metabolism_Homo sapiens_hsa000520.47751680
106Renin-angiotensin system_Homo sapiens_hsa046140.47153092
107Allograft rejection_Homo sapiens_hsa053300.46705466
108Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.45385613
109Drug metabolism - other enzymes_Homo sapiens_hsa009830.43300112
110Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43260930
111Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.43123245
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43065097
113RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.42612329
114Salmonella infection_Homo sapiens_hsa051320.42015387
115Nucleotide excision repair_Homo sapiens_hsa034200.41712434
116Toll-like receptor signaling pathway_Homo sapiens_hsa046200.40730480
117Autoimmune thyroid disease_Homo sapiens_hsa053200.39900277
118Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.39578917
119Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38808616
120Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.38738095
121Asthma_Homo sapiens_hsa053100.37310832
122RNA polymerase_Homo sapiens_hsa030200.36813604
123African trypanosomiasis_Homo sapiens_hsa051430.36568104
124Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36504626
125Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36228372
126Leishmaniasis_Homo sapiens_hsa051400.34929290
127Tuberculosis_Homo sapiens_hsa051520.34692657
128Jak-STAT signaling pathway_Homo sapiens_hsa046300.33984895
129Glycerophospholipid metabolism_Homo sapiens_hsa005640.33746449
1302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.33566528
131Chemokine signaling pathway_Homo sapiens_hsa040620.32992148
132Glycosaminoglycan degradation_Homo sapiens_hsa005310.32673466
133Carbon metabolism_Homo sapiens_hsa012000.32051533
134RNA transport_Homo sapiens_hsa030130.31348391
135Shigellosis_Homo sapiens_hsa051310.30985631
136p53 signaling pathway_Homo sapiens_hsa041150.30405757
137Huntingtons disease_Homo sapiens_hsa050160.30300104
138Prion diseases_Homo sapiens_hsa050200.29767839
139Regulation of autophagy_Homo sapiens_hsa041400.29467731
140Ovarian steroidogenesis_Homo sapiens_hsa049130.29135047
141Hepatitis C_Homo sapiens_hsa051600.28119390

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