DRC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a central component of the nexin-dynein complex (N-DRC), which regulates the assembly of ciliary dynein. Mutations in this gene can cause ciliary dyskinesia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium movement (GO:0003341)9.79116271
2epithelial cilium movement (GO:0003351)9.30903013
3epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.28450367
4motile cilium assembly (GO:0044458)7.92792897
5sperm motility (GO:0030317)7.32010642
6regulation of cilium movement (GO:0003352)7.22805878
7fusion of sperm to egg plasma membrane (GO:0007342)7.02076836
8acrosome assembly (GO:0001675)6.83002857
9axoneme assembly (GO:0035082)6.42203683
10acrosome reaction (GO:0007340)6.38747159
11multicellular organism reproduction (GO:0032504)6.36710684
12primary alcohol catabolic process (GO:0034310)6.28182327
13ventricular system development (GO:0021591)6.09205957
14sperm-egg recognition (GO:0035036)6.07816720
15vitamin transmembrane transport (GO:0035461)5.73808450
16protein localization to cilium (GO:0061512)5.66567705
17plasma membrane fusion (GO:0045026)5.58747402
18male meiosis (GO:0007140)5.51221355
19piRNA metabolic process (GO:0034587)5.50614573
20binding of sperm to zona pellucida (GO:0007339)5.49404505
21spermatid development (GO:0007286)5.47426548
22cell-cell recognition (GO:0009988)5.40558446
23cell wall macromolecule metabolic process (GO:0044036)5.40166340
24cell wall macromolecule catabolic process (GO:0016998)5.40166340
25intraciliary transport (GO:0042073)5.30698863
26ethanol metabolic process (GO:0006067)5.23200936
27reproduction (GO:0000003)5.02510678
28diterpenoid biosynthetic process (GO:0016102)5.00829150
29lung epithelium development (GO:0060428)4.69193241
30single fertilization (GO:0007338)4.63010203
31synaptonemal complex organization (GO:0070193)4.62179990
32microtubule severing (GO:0051013)4.53656166
33negative regulation of inclusion body assembly (GO:0090084)4.49526671
34one-carbon compound transport (GO:0019755)4.48767862
35calcium ion-dependent exocytosis (GO:0017156)4.40222212
36nucleoside diphosphate phosphorylation (GO:0006165)4.39828964
37cilium organization (GO:0044782)4.37455650
38regulation of microtubule-based movement (GO:0060632)4.35910027
39response to xenobiotic stimulus (GO:0009410)4.33847855
40cilium assembly (GO:0042384)4.29136474
41tolerance induction (GO:0002507)4.25934289
42pyrimidine-containing compound transmembrane transport (GO:0072531)4.19955481
43glomerular epithelial cell development (GO:0072310)4.18850201
44GTP biosynthetic process (GO:0006183)4.18578484
45establishment of apical/basal cell polarity (GO:0035089)4.16681582
46synaptonemal complex assembly (GO:0007130)4.13373586
47negative regulation of T cell differentiation in thymus (GO:0033085)4.12069501
48negative regulation of immunoglobulin mediated immune response (GO:0002890)4.11075473
49negative regulation of B cell mediated immunity (GO:0002713)4.11075473
50cilium morphogenesis (GO:0060271)4.10532499
51male meiosis I (GO:0007141)4.00092298
52protein polyglutamylation (GO:0018095)3.99937230
53regulation of interleukin-5 production (GO:0032674)3.97761661
54ethanol oxidation (GO:0006069)3.97092683
55establishment of monopolar cell polarity (GO:0061162)3.96302891
56establishment or maintenance of monopolar cell polarity (GO:0061339)3.96302891
57sensory perception of smell (GO:0007608)3.85047269
58establishment of tissue polarity (GO:0007164)3.83102382
59establishment of planar polarity (GO:0001736)3.83102382
60negative regulation of humoral immune response (GO:0002921)3.82065103
61lateral ventricle development (GO:0021670)3.81984031
62fertilization (GO:0009566)3.79717276
63sperm capacitation (GO:0048240)3.75396341
64left/right axis specification (GO:0070986)3.72695582
65microtubule-based movement (GO:0007018)3.71846076
66regulation of inclusion body assembly (GO:0090083)3.67951208
67terpenoid biosynthetic process (GO:0016114)3.63512322
68microtubule polymerization or depolymerization (GO:0031109)3.62261579
69retinoic acid metabolic process (GO:0042573)3.61835375
70spermatogenesis (GO:0007283)3.60218560
71male gamete generation (GO:0048232)3.58688840
72cytoplasmic microtubule organization (GO:0031122)3.58107103
73cellular component assembly involved in morphogenesis (GO:0010927)3.58083134
74DNA methylation involved in gamete generation (GO:0043046)3.55977597
75UTP biosynthetic process (GO:0006228)3.54615545
76left/right pattern formation (GO:0060972)3.50559185
77regulation of interleukin-13 production (GO:0032656)3.48843204
78negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.48709250
79guanosine-containing compound biosynthetic process (GO:1901070)3.47691718
80positive regulation of tolerance induction (GO:0002645)3.46484843
81determination of left/right symmetry (GO:0007368)3.45113953
82smoothened signaling pathway (GO:0007224)3.43804582
83positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.36798314
84gamete generation (GO:0007276)3.34695713
85determination of bilateral symmetry (GO:0009855)3.32308302
86regulation of germinal center formation (GO:0002634)3.30136921
87cell recognition (GO:0008037)3.28371843
88lateral sprouting from an epithelium (GO:0060601)3.28266319
89meiosis I (GO:0007127)3.28170310
90specification of symmetry (GO:0009799)3.24995634
91regulation of short-term neuronal synaptic plasticity (GO:0048172)3.24156206
92microtubule bundle formation (GO:0001578)3.22587857
93retinal rod cell development (GO:0046548)3.17625945
94positive regulation of smoothened signaling pathway (GO:0045880)3.08984567
95detection of calcium ion (GO:0005513)3.04947539
96microtubule-based process (GO:0007017)3.04005236
97UTP metabolic process (GO:0046051)3.03380593
98exogenous drug catabolic process (GO:0042738)3.01889097
99cellular process involved in reproduction in multicellular organism (GO:0022412)3.00778890
100positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.99392252
101germ cell development (GO:0007281)2.99321482
102nonmotile primary cilium assembly (GO:0035058)2.95992893
103microtubule depolymerization (GO:0007019)2.95691987
104centriole assembly (GO:0098534)2.94956117
105apical protein localization (GO:0045176)2.93141438
106CTP metabolic process (GO:0046036)2.92803133
107CTP biosynthetic process (GO:0006241)2.92803133
108meiotic nuclear division (GO:0007126)2.92102945
109regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.89393667
110chromosome organization involved in meiosis (GO:0070192)2.89377082
111glutathione derivative metabolic process (GO:1901685)2.87365344
112glutathione derivative biosynthetic process (GO:1901687)2.87365344
113organelle assembly (GO:0070925)2.83797287
114vocalization behavior (GO:0071625)2.82718178
115spermatid nucleus differentiation (GO:0007289)2.80893316
116startle response (GO:0001964)2.79783276
117meiotic cell cycle (GO:0051321)2.79073633
118adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.78984849
119primary alcohol metabolic process (GO:0034308)2.78429277
120regulation of microtubule depolymerization (GO:0031114)2.76918482
121positive regulation of synaptic transmission, GABAergic (GO:0032230)2.75416489
122retinol metabolic process (GO:0042572)2.73799477
123cell projection assembly (GO:0030031)2.73760766
124regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.73637367
125aldehyde catabolic process (GO:0046185)2.73083955
126hydrogen peroxide biosynthetic process (GO:0050665)2.72883807
127neuron cell-cell adhesion (GO:0007158)2.72578706
128regulation of glutamate receptor signaling pathway (GO:1900449)2.71805024
129protein localization to synapse (GO:0035418)2.69849693
130multicellular organismal reproductive process (GO:0048609)2.66510141
131glutamate secretion (GO:0014047)2.65324269
132O-glycan processing (GO:0016266)2.65236828
133ionotropic glutamate receptor signaling pathway (GO:0035235)2.65142258
134sensory perception of chemical stimulus (GO:0007606)2.64904732
135centriole replication (GO:0007099)2.64298302
136organic cation transport (GO:0015695)2.62492080
137female mating behavior (GO:0060180)2.62148695
138heart looping (GO:0001947)2.61755799
139regulation of protein kinase A signaling (GO:0010738)2.59008089
140synaptic vesicle docking involved in exocytosis (GO:0016081)2.58889192
141carnitine metabolic process (GO:0009437)2.57098419
142membrane depolarization during action potential (GO:0086010)2.55898310
143synaptic transmission, glutamatergic (GO:0035249)2.54548258
144pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.54282001
145regulation of synaptic vesicle transport (GO:1902803)2.53757224
146regulation of synaptic vesicle exocytosis (GO:2000300)2.53527840
147regulation of collateral sprouting (GO:0048670)2.50566717
148nucleotide phosphorylation (GO:0046939)2.50232695
149regulation of autophagic vacuole assembly (GO:2000785)2.49978516
150photoreceptor cell maintenance (GO:0045494)2.49657773
151regulation of smoothened signaling pathway (GO:0008589)2.49615283
152negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.49614125
153calcium ion import (GO:0070509)2.48756279
154neuron-neuron synaptic transmission (GO:0007270)2.48540290
155regulation of tolerance induction (GO:0002643)2.47501175
156excretion (GO:0007588)2.42501765
157embryonic heart tube morphogenesis (GO:0003143)2.42484780
158asymmetric protein localization (GO:0008105)2.42126839
159reactive oxygen species biosynthetic process (GO:1903409)2.40412570
160embryonic camera-type eye development (GO:0031076)2.39913470
161dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.36288851
162phosphatidylcholine biosynthetic process (GO:0006656)2.35377386
163ear development (GO:0043583)2.32868677
164drug catabolic process (GO:0042737)2.31212533
165establishment or maintenance of apical/basal cell polarity (GO:0035088)2.29303491
166establishment or maintenance of bipolar cell polarity (GO:0061245)2.29303491
167phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.27378334
168* cilium or flagellum-dependent cell motility (GO:0001539)11.2113584
169* axonemal dynein complex assembly (GO:0070286)10.4965512

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.56326417
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.44524870
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.16435361
4MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.84637787
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.88031618
6FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.75424787
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.49363888
8GBX2_23144817_ChIP-Seq_PC3_Human2.45033591
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.30231700
10REST_21632747_ChIP-Seq_MESCs_Mouse2.25173760
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.18312850
12TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.10373185
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.09998317
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.08068352
15NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.07492876
16PIAS1_25552417_ChIP-Seq_VCAP_Human2.01024969
17CTBP2_25329375_ChIP-Seq_LNCAP_Human2.00032229
18TAF15_26573619_Chip-Seq_HEK293_Human1.93868092
19PCGF2_27294783_Chip-Seq_ESCs_Mouse1.88035589
20RNF2_27304074_Chip-Seq_NSC_Mouse1.86313614
21CBX2_27304074_Chip-Seq_ESCs_Mouse1.80734564
22ESR1_20079471_ChIP-ChIP_T-47D_Human1.79679141
23AHR_22903824_ChIP-Seq_MCF-7_Human1.74689957
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.74371282
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.67488255
26NR3C1_21868756_ChIP-Seq_MCF10A_Human1.66519736
27SMAD4_21799915_ChIP-Seq_A2780_Human1.64747614
28VDR_22108803_ChIP-Seq_LS180_Human1.64663251
29PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.63962965
30GATA1_26923725_Chip-Seq_HPCs_Mouse1.63260241
31CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.61245405
32POU3F2_20337985_ChIP-ChIP_501MEL_Human1.59494951
33TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.58977073
34ARNT_22903824_ChIP-Seq_MCF-7_Human1.57380739
35SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.56325360
36FOXM1_26456572_ChIP-Seq_MCF-7_Human1.53378729
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.51262879
38NANOG_18555785_Chip-Seq_ESCs_Mouse1.50675265
39REST_18959480_ChIP-ChIP_MESCs_Mouse1.49793866
40FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.49719358
41SUZ12_27294783_Chip-Seq_NPCs_Mouse1.47336152
42SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.47312737
43TP53_18474530_ChIP-ChIP_U2OS_Human1.46232407
44PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.46211533
45KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.45707713
46P300_19829295_ChIP-Seq_ESCs_Human1.45698501
47IKZF1_21737484_ChIP-ChIP_HCT116_Human1.45389785
48EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.44437958
49CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.44420365
50SMC4_20622854_ChIP-Seq_HELA_Human1.44163019
51ZNF274_21170338_ChIP-Seq_K562_Hela1.43967680
52SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.42927082
53TP63_23658742_ChIP-Seq_EP156T_Human1.42677330
54DROSHA_22980978_ChIP-Seq_HELA_Human1.42031021
55RUNX1_27514584_Chip-Seq_MCF-7_Human1.41604380
56NFE2_27457419_Chip-Seq_LIVER_Mouse1.39977668
57POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.39805828
58TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39805828
59PCGF2_27294783_Chip-Seq_NPCs_Mouse1.39354018
60BMI1_23680149_ChIP-Seq_NPCS_Mouse1.37556337
61EZH2_27294783_Chip-Seq_ESCs_Mouse1.36691372
62P53_22387025_ChIP-Seq_ESCs_Mouse1.35064064
63SUZ12_27294783_Chip-Seq_ESCs_Mouse1.34983366
64ETV1_20927104_ChIP-Seq_GIST48_Human1.34255292
65MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.34125203
66FUS_26573619_Chip-Seq_HEK293_Human1.33685291
67ER_23166858_ChIP-Seq_MCF-7_Human1.33157639
68TAL1_26923725_Chip-Seq_HPCs_Mouse1.32815590
69ZNF217_24962896_ChIP-Seq_MCF-7_Human1.31758438
70STAT1_20625510_ChIP-Seq_HELA_Human1.30275587
71TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.30118689
72PHF8_20622853_ChIP-Seq_HELA_Human1.28497627
73CTNNB1_20460455_ChIP-Seq_HCT116_Human1.28379468
74TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.28212214
75TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27842436
76KLF5_25053715_ChIP-Seq_YYC3_Human1.27378552
77SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.27040156
78SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26986136
79MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26539796
80CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26280606
81RBPJ_22232070_ChIP-Seq_NCS_Mouse1.25643919
82RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.24983571
83ELK4_26923725_Chip-Seq_MESODERM_Mouse1.24667376
84STAT3_18555785_Chip-Seq_ESCs_Mouse1.23822805
85TCF4_23295773_ChIP-Seq_U87_Human1.23517744
86MTF2_20144788_ChIP-Seq_MESCs_Mouse1.23462236
87SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.23175211
88SMAD3_21741376_ChIP-Seq_EPCs_Human1.23040376
89CMYC_18555785_Chip-Seq_ESCs_Mouse1.22975217
90CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.22822101
91STAT3_23295773_ChIP-Seq_U87_Human1.22777894
92E2F1_18555785_Chip-Seq_ESCs_Mouse1.22729833
93SOX2_18555785_Chip-Seq_ESCs_Mouse1.22398296
94AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.22191016
95HNFA_21074721_ChIP-Seq_CACO-2_Human1.22043078
96SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.21974830
97IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.21523954
98CBP_20019798_ChIP-Seq_JUKART_Human1.21523954
99PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.21347694
100AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20880388
101EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.20593504
102SUZ12_18555785_Chip-Seq_ESCs_Mouse1.19909592
103TP63_22573176_ChIP-Seq_HFKS_Human1.19323006
104ESR2_21235772_ChIP-Seq_MCF-7_Human1.19051049
105JARID2_20064375_ChIP-Seq_MESCs_Mouse1.18323767
106FLI1_21867929_ChIP-Seq_TH2_Mouse1.18275539
107SOX2_27498859_Chip-Seq_STOMACH_Mouse1.17983431
108EZH2_27304074_Chip-Seq_ESCs_Mouse1.17258516
109RAD21_21589869_ChIP-Seq_MESCs_Mouse1.17191016
110P300_18555785_Chip-Seq_ESCs_Mouse1.17105804
111FOXA1_25552417_ChIP-Seq_VCAP_Human1.16821492
112CTCF_27219007_Chip-Seq_Bcells_Human1.16204927
113ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.15873364
114OCT4_18555785_Chip-Seq_ESCs_Mouse1.15759422
115KAP1_22055183_ChIP-Seq_ESCs_Mouse1.15512220
116KDM2B_26808549_Chip-Seq_REH_Human1.15310534
117AR_21572438_ChIP-Seq_LNCaP_Human1.14814408
118TDRD3_21172665_ChIP-Seq_MCF-7_Human1.14477268
119PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.14341898
120RNF2_27304074_Chip-Seq_ESCs_Mouse1.13883641
121SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.13878076
122RARB_27405468_Chip-Seq_BRAIN_Mouse1.13870166
123SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.13764306
124TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13303413
125RUNX1_27457419_Chip-Seq_LIVER_Mouse1.12916076
126KLF4_18555785_Chip-Seq_ESCs_Mouse1.12914320
127CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.12907283
128TBL1_22424771_ChIP-Seq_293T_Human1.11824932
129EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.11587485
130UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10861510
131TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10139704
132NFYA_21822215_ChIP-Seq_K562_Human1.09633560
133AR_25329375_ChIP-Seq_VCAP_Human1.09553450
134SOX9_24532713_ChIP-Seq_HFSC_Mouse1.08815727
135EZH2_27294783_Chip-Seq_NPCs_Mouse1.08715458
136NMYC_18555785_Chip-Seq_ESCs_Mouse1.08306706
137SMRT_27268052_Chip-Seq_Bcells_Human1.08211161
138RBPJ_21746931_ChIP-Seq_IB4_Human1.08118973
139WDR5_24793694_ChIP-Seq_LNCAP_Human1.07280444
140ESRRB_18555785_Chip-Seq_ESCs_Mouse1.06784157
141ZFX_18555785_Chip-Seq_ESCs_Mouse1.06246742
142PU1_27457419_Chip-Seq_LIVER_Mouse1.05590272
143ESR1_21235772_ChIP-Seq_MCF-7_Human1.05241248
144CBX2_22325352_ChIP-Seq_293T-Rex_Human1.04873594
145NFYB_21822215_ChIP-Seq_K562_Human1.04806036
146SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.01602258
147GATA6_21074721_ChIP-Seq_CACO-2_Human1.00633293
148P63_26484246_Chip-Seq_KERATINOCYTES_Human0.99962700
149SMAD3_21741376_ChIP-Seq_HESCs_Human0.98777283
150CDX2_20551321_ChIP-Seq_CACO-2_Human0.97414713
151SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.96663794
152SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.95426945
153SOX2_20726797_ChIP-Seq_SW620_Human0.95242791
154JARID2_20075857_ChIP-Seq_MESCs_Mouse0.93730974
155ELF1_20517297_ChIP-Seq_JURKAT_Human0.93438408
156TCF4_22108803_ChIP-Seq_LS180_Human0.93294455
157TP53_16413492_ChIP-PET_HCT116_Human0.93169071
158GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.92652323
159CTCF_20526341_ChIP-Seq_ESCs_Human0.92490135
160BCAT_22108803_ChIP-Seq_LS180_Human0.90744233
161AR_19668381_ChIP-Seq_PC3_Human0.90740408
162YY1_22570637_ChIP-Seq_MALME-3M_Human0.89080636
163SMAD4_21741376_ChIP-Seq_EPCs_Human0.88822694
164EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.86810442
165SMAD4_21741376_ChIP-Seq_HESCs_Human0.85405947
166RUNX2_22187159_ChIP-Seq_PCA_Human0.84338654
167CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.84228859

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization6.97180425
2MP0008875_abnormal_xenobiotic_pharmacok5.44672709
3MP0001984_abnormal_olfaction4.47716982
4MP0002132_abnormal_respiratory_system4.44846430
5MP0000566_synostosis3.42863224
6MP0009780_abnormal_chondrocyte_physiolo3.20138612
7MP0002653_abnormal_ependyma_morphology3.19929735
8MP0003698_abnormal_male_reproductive3.09982194
9MP0008877_abnormal_DNA_methylation3.07719729
10MP0004859_abnormal_synaptic_plasticity3.05198674
11MP0003880_abnormal_central_pattern2.95285940
12MP0004043_abnormal_pH_regulation2.92301972
13MP0005377_hearing/vestibular/ear_phenot2.82420456
14MP0003878_abnormal_ear_physiology2.82420456
15MP0009046_muscle_twitch2.79142000
16MP0001929_abnormal_gametogenesis2.62089111
17MP0005645_abnormal_hypothalamus_physiol2.56260449
18MP0002282_abnormal_trachea_morphology2.55930836
19MP0003635_abnormal_synaptic_transmissio2.52499077
20MP0009745_abnormal_behavioral_response2.49349452
21MP0005423_abnormal_somatic_nervous2.42543090
22MP0001968_abnormal_touch/_nociception2.39734912
23MP0004270_analgesia2.26365322
24MP0005646_abnormal_pituitary_gland2.26288533
25MP0002822_catalepsy2.25692435
26MP0002572_abnormal_emotion/affect_behav2.24226214
27MP0002736_abnormal_nociception_after2.21362909
28MP0002063_abnormal_learning/memory/cond2.20733326
29MP0000383_abnormal_hair_follicle2.15376014
30MP0002734_abnormal_mechanical_nocicepti2.09026774
31MP0002064_seizures2.04499246
32MP0003879_abnormal_hair_cell2.03613326
33MP0004019_abnormal_vitamin_homeostasis1.99381505
34MP0001529_abnormal_vocalization1.98711292
35MP0001440_abnormal_grooming_behavior1.94131279
36MP0003787_abnormal_imprinting1.84490889
37MP0002909_abnormal_adrenal_gland1.84294414
38MP0002272_abnormal_nervous_system1.82067041
39MP0001486_abnormal_startle_reflex1.80689105
40MP0010030_abnormal_orbit_morphology1.80636562
41MP0002210_abnormal_sex_determination1.77552741
42MP0003136_yellow_coat_color1.73749014
43MP0002249_abnormal_larynx_morphology1.71963089
44MP0006276_abnormal_autonomic_nervous1.68661387
45MP0010678_abnormal_skin_adnexa1.67267014
46MP0002557_abnormal_social/conspecific_i1.66694770
47MP0005248_abnormal_Harderian_gland1.66301134
48MP0002161_abnormal_fertility/fecundity1.66010724
49MP0001501_abnormal_sleep_pattern1.58498029
50MP0002638_abnormal_pupillary_reflex1.55813911
51MP0001502_abnormal_circadian_rhythm1.54881905
52MP0002735_abnormal_chemical_nociception1.50648663
53MP0002184_abnormal_innervation1.49740744
54MP0010386_abnormal_urinary_bladder1.41634822
55MP0002168_other_aberrant_phenotype1.41228800
56MP0002160_abnormal_reproductive_system1.38740289
57MP0001145_abnormal_male_reproductive1.38266188
58MP0002067_abnormal_sensory_capabilities1.37448712
59MP0000013_abnormal_adipose_tissue1.34175700
60MP0001188_hyperpigmentation1.32943265
61MP0001970_abnormal_pain_threshold1.32932235
62MP0000778_abnormal_nervous_system1.32870200
63MP0001346_abnormal_lacrimal_gland1.32469101
64MP0002233_abnormal_nose_morphology1.31741407
65MP0001905_abnormal_dopamine_level1.30589329
66MP0000653_abnormal_sex_gland1.30026464
67MP0004742_abnormal_vestibular_system1.29338822
68MP0009379_abnormal_foot_pigmentation1.28944870
69MP0005083_abnormal_biliary_tract1.28537029
70MP0005379_endocrine/exocrine_gland_phen1.27218897
71MP0002733_abnormal_thermal_nociception1.25206935
72MP0005551_abnormal_eye_electrophysiolog1.24903319
73MP0005623_abnormal_meninges_morphology1.24168989
74MP0002928_abnormal_bile_duct1.19985619
75MP0004924_abnormal_behavior1.19981345
76MP0005386_behavior/neurological_phenoty1.19981345
77MP0006292_abnormal_olfactory_placode1.19171871
78MP0005499_abnormal_olfactory_system1.18353864
79MP0005394_taste/olfaction_phenotype1.18353864
80MP0003656_abnormal_erythrocyte_physiolo1.18346849
81MP0001485_abnormal_pinna_reflex1.16467272
82MP0001986_abnormal_taste_sensitivity1.15133551
83MP0004885_abnormal_endolymph1.12596768
84MP0004811_abnormal_neuron_physiology1.09734679
85MP0001293_anophthalmia1.07501826
86MP0003122_maternal_imprinting1.06963458
87MP0005409_darkened_coat_color1.04779862
88MP0000678_abnormal_parathyroid_gland1.04323150
89MP0000631_abnormal_neuroendocrine_gland1.03466203
90MP0002882_abnormal_neuron_morphology1.02321555
91MP0005389_reproductive_system_phenotype0.94209395
92MP0003633_abnormal_nervous_system0.94143691
93MP0002152_abnormal_brain_morphology0.92207518
94MP0003938_abnormal_ear_development0.90528245
95MP0001324_abnormal_eye_pigmentation0.89774852
96MP0001963_abnormal_hearing_physiology0.89520816
97MP0000955_abnormal_spinal_cord0.89326635
98MP0003937_abnormal_limbs/digits/tail_de0.89299550
99MP0003183_abnormal_peptide_metabolism0.88779195
100MP0000049_abnormal_middle_ear0.88314368
101MP0008995_early_reproductive_senescence0.87314467
102MP0001765_abnormal_ion_homeostasis0.86835024
103MP0008789_abnormal_olfactory_epithelium0.86610995
104MP0002066_abnormal_motor_capabilities/c0.86277765
105MP0004858_abnormal_nervous_system0.85660646
106MP0005395_other_phenotype0.82941529
107MP0000026_abnormal_inner_ear0.82567639
108MP0004133_heterotaxia0.81953278
109MP0002876_abnormal_thyroid_physiology0.80324055
110MP0002752_abnormal_somatic_nervous0.78373413
111MP0005636_abnormal_mineral_homeostasis0.77596502
112MP0002116_abnormal_craniofacial_bone0.77567963
113MP0005195_abnormal_posterior_eye0.77197295
114MP0005391_vision/eye_phenotype0.76296328
115MP0005503_abnormal_tendon_morphology0.74484045
116MP0003329_amyloid_beta_deposits0.74125793
117MP0002229_neurodegeneration0.73522831
118MP0001270_distended_abdomen0.73070405
119MP0003942_abnormal_urinary_system0.72909694
120MP0002069_abnormal_eating/drinking_beha0.72416253
121MP0006072_abnormal_retinal_apoptosis0.71588278
122MP0003121_genomic_imprinting0.70442012
123MP0008569_lethality_at_weaning0.70350362
124MP0001299_abnormal_eye_distance/0.70260307
125MP0002102_abnormal_ear_morphology0.70041109
126MP0003631_nervous_system_phenotype0.67142187
127MP0005085_abnormal_gallbladder_physiolo0.66457759
128MP0005365_abnormal_bile_salt0.66294221
129MP0001944_abnormal_pancreas_morphology0.64810166
130MP0002163_abnormal_gland_morphology0.64191988
131MP0005253_abnormal_eye_physiology0.62942503
132MP0003634_abnormal_glial_cell0.62841142
133MP0005084_abnormal_gallbladder_morpholo0.61592049
134MP0004883_abnormal_blood_vessel0.60136566
135MP0003646_muscle_fatigue0.60041487
136MP0002092_abnormal_eye_morphology0.59707096
137MP0002277_abnormal_respiratory_mucosa0.59294360
138MP0002693_abnormal_pancreas_physiology0.59217136
139MP0009703_decreased_birth_body0.56820335
140MP0005165_increased_susceptibility_to0.56416609
141MP0000681_abnormal_thyroid_gland0.55538808
142MP0003861_abnormal_nervous_system0.55083158
143MP0001177_atelectasis0.54481579
144MP0009765_abnormal_xenobiotic_induced0.54149309
145MP0003283_abnormal_digestive_organ0.53990227
146MP0000465_gastrointestinal_hemorrhage0.52317698
147MP0002098_abnormal_vibrissa_morphology0.51123726
148MP0001849_ear_inflammation0.50015933
149MP0009643_abnormal_urine_homeostasis0.49455696
150MP0002084_abnormal_developmental_patter0.48684679
151MP0005164_abnormal_response_to0.48633365
152MP0002136_abnormal_kidney_physiology0.48039096
153MP0005220_abnormal_exocrine_pancreas0.47798748

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.89600027
2Dynein arm defect of respiratory motile cilia (HP:0012255)9.53430052
3Absent/shortened dynein arms (HP:0200106)9.53430052
4Abnormal ciliary motility (HP:0012262)8.99154982
5Abnormal respiratory motile cilium morphology (HP:0005938)8.23576216
6Abnormal respiratory epithelium morphology (HP:0012253)8.23576216
7Rhinitis (HP:0012384)8.15031375
8Chronic bronchitis (HP:0004469)6.70442328
9* Bronchiectasis (HP:0002110)4.44559985
10Infertility (HP:0000789)4.31907307
11Nasal polyposis (HP:0100582)4.22288991
12Nephronophthisis (HP:0000090)3.95766230
13Medial flaring of the eyebrow (HP:0010747)3.68867894
14Molar tooth sign on MRI (HP:0002419)3.53043684
15Abnormality of midbrain morphology (HP:0002418)3.53043684
16Pancreatic fibrosis (HP:0100732)3.47236152
17Bronchitis (HP:0012387)3.36583156
18Abnormality of the nasal mucosa (HP:0000433)3.30841619
19Gait imbalance (HP:0002141)3.30342760
20Abnormality of the renal medulla (HP:0100957)3.21206422
21Congenital primary aphakia (HP:0007707)3.20335353
22True hermaphroditism (HP:0010459)2.97276014
23Nephrogenic diabetes insipidus (HP:0009806)2.95574325
24Chronic otitis media (HP:0000389)2.88868943
25Recurrent sinusitis (HP:0011108)2.77733809
26Tubulointerstitial nephritis (HP:0001970)2.73620230
27Median cleft lip (HP:0000161)2.72704905
28Focal motor seizures (HP:0011153)2.55947421
29Hyperactive renin-angiotensin system (HP:0000841)2.54995737
30Poor coordination (HP:0002370)2.50018648
31Chronic sinusitis (HP:0011109)2.49000520
32Pancreatic cysts (HP:0001737)2.46872812
33Genital tract atresia (HP:0001827)2.39684447
34Congenital hepatic fibrosis (HP:0002612)2.34843098
35Occipital encephalocele (HP:0002085)2.34772542
36Postaxial foot polydactyly (HP:0001830)2.34182070
37Vaginal atresia (HP:0000148)2.29382826
38Tubulointerstitial abnormality (HP:0001969)2.28385742
39* Recurrent otitis media (HP:0000403)2.26649154
40Postaxial hand polydactyly (HP:0001162)2.16626935
41Cystic liver disease (HP:0006706)2.16313403
42Fibular hypoplasia (HP:0003038)2.13859944
43Aplasia/Hypoplasia of the lens (HP:0008063)2.13023342
44* Atelectasis (HP:0100750)2.07390158
45Epileptic encephalopathy (HP:0200134)2.04185143
46Abnormal drinking behavior (HP:0030082)2.00939221
47Polydipsia (HP:0001959)2.00939221
48Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.0508417
49Bifid tongue (HP:0010297)1.99415727
50Male infertility (HP:0003251)1.97763632
51Chronic hepatic failure (HP:0100626)1.92303642
52Tubular atrophy (HP:0000092)1.92038232
53Oculomotor apraxia (HP:0000657)1.91530618
54Aplasia/Hypoplasia of the tongue (HP:0010295)1.91428228
55Retinal dysplasia (HP:0007973)1.90298662
56Sclerocornea (HP:0000647)1.90140661
57Tubulointerstitial fibrosis (HP:0005576)1.86193385
58Abnormal biliary tract physiology (HP:0012439)1.86066416
59Bile duct proliferation (HP:0001408)1.86066416
60Abnormality of the dental root (HP:0006486)1.82969983
61Taurodontia (HP:0000679)1.82969983
62Abnormality of permanent molar morphology (HP:0011071)1.82969983
63Recurrent bronchitis (HP:0002837)1.81126307
64Supernumerary spleens (HP:0009799)1.80967880
65Abnormality of the dental pulp (HP:0006479)1.76822627
66Papillary thyroid carcinoma (HP:0002895)1.76512902
67Absent frontal sinuses (HP:0002688)1.74602573
68Facial cleft (HP:0002006)1.73217659
69Abnormality of the renal cortex (HP:0011035)1.72843663
70Limb dystonia (HP:0002451)1.72578612
71Specific learning disability (HP:0001328)1.72109531
72Focal seizures (HP:0007359)1.70916051
73Myokymia (HP:0002411)1.70403852
74Aplasia/Hypoplasia of the spleen (HP:0010451)1.70309553
75Furrowed tongue (HP:0000221)1.69852184
76Abnormality of molar morphology (HP:0011070)1.69589017
77Abnormality of molar (HP:0011077)1.69589017
78Asplenia (HP:0001746)1.68416388
79Stage 5 chronic kidney disease (HP:0003774)1.67905128
80Abnormality of dentin (HP:0010299)1.66910271
81Atonic seizures (HP:0010819)1.65561725
82Decreased circulating renin level (HP:0003351)1.59784141
83Febrile seizures (HP:0002373)1.58017390
84Abnormality of the lower motor neuron (HP:0002366)1.57728196
85Aganglionic megacolon (HP:0002251)1.55654371
86Preaxial hand polydactyly (HP:0001177)1.54038163
87Nephropathy (HP:0000112)1.53877667
88Renal salt wasting (HP:0000127)1.51753077
89Progressive cerebellar ataxia (HP:0002073)1.51532144
90Broad foot (HP:0001769)1.51311109
91Hemiparesis (HP:0001269)1.49310148
92Retinitis pigmentosa (HP:0000510)1.48884354
93Bell-shaped thorax (HP:0001591)1.47449465
94Abnormality of renal excretion (HP:0011036)1.47396278
95Polyuria (HP:0000103)1.45389955
96Amyotrophic lateral sclerosis (HP:0007354)1.44245282
97Abnormal hair whorl (HP:0010721)1.43572889
98Hyperventilation (HP:0002883)1.42723094
99Decreased central vision (HP:0007663)1.42340008
100Gaze-evoked nystagmus (HP:0000640)1.40372658
101Hyperkalemia (HP:0002153)1.40011670
102Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.36550685
103Abnormal urine output (HP:0012590)1.36462771
104Visual hallucinations (HP:0002367)1.35701052
105Aplasia/Hypoplasia of the fibula (HP:0006492)1.34653290
106Abnormal spermatogenesis (HP:0008669)1.32812242
107Bony spicule pigmentary retinopathy (HP:0007737)1.31973678
108Anencephaly (HP:0002323)1.31913756
109Abnormality of macular pigmentation (HP:0008002)1.31615143
110Left ventricular hypertrophy (HP:0001712)1.31347215
111Absent rod-and cone-mediated responses on ERG (HP:0007688)1.29354954
112Male pseudohermaphroditism (HP:0000037)1.28724109
113Narrow forehead (HP:0000341)1.26904848
114Renal dysplasia (HP:0000110)1.26897691
115Short nail (HP:0001799)1.26553304
116Hyperaldosteronism (HP:0000859)1.26389219
117Cone-rod dystrophy (HP:0000548)1.22154726
118Short thorax (HP:0010306)1.21421965
119Bifid scrotum (HP:0000048)1.13909861
120Abnormality of renin-angiotensin system (HP:0000847)1.12944133
121Abnormality of chloride homeostasis (HP:0011422)1.09316042
122Abnormality of the frontal sinuses (HP:0002687)1.08204317
123Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.06123680
124Prominent nasal bridge (HP:0000426)1.04306019
125Fetal akinesia sequence (HP:0001989)1.03655997
126Multicystic kidney dysplasia (HP:0000003)1.01119445
127Short femoral neck (HP:0100864)0.98738121
128Hypokalemic alkalosis (HP:0001949)0.96574562

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK155.12063472
2PDK34.81393999
3PDK44.81393999
4MST44.52171626
5EPHA23.90624706
6PNCK2.90217629
7PDK22.82322433
8WNK32.81996590
9EPHA42.72546898
10PRKD32.59724437
11NTRK32.51912216
12CASK2.36989935
13BCR2.28221550
14NTRK22.24180973
15ICK2.00751700
16MAPKAPK31.91055395
17ARAF1.89943712
18MAP2K71.89835854
19WNK41.83250572
20DAPK21.73939107
21STK241.67754463
22PTK2B1.64718821
23MAP3K91.62178241
24TESK11.61743014
25MAP3K41.55741008
26NME11.54109700
27CAMKK21.45571416
28AKT31.43165494
29PINK11.40935156
30MARK11.39706255
31CCNB11.38397363
32GRK71.30624867
33PRKCG1.29196814
34STK381.24403618
35CSK1.24389373
36CAMKK11.23027743
37BRAF1.19981284
38MINK11.14977317
39ADRBK21.12441000
40TTK1.10057702
41PLK21.09772032
42EPHB11.08425752
43LRRK21.08078808
44RIPK41.07276645
45CDK31.05720041
46MAP3K31.05483890
47SIK31.05442236
48MAP3K121.04660546
49DAPK11.04396452
50BMPR1B1.02509117
51TYRO31.01683607
52MAP3K71.01383460
53EEF2K1.01033932
54TLK11.00528028
55EPHA31.00374716
56SMG10.98531439
57FRK0.96436543
58GRK50.94627303
59MAPK130.90006718
60DYRK1B0.86967873
61PRPF4B0.86878578
62ERBB20.83484580
63SGK20.83422131
64PAK60.80602641
65BMPR20.80412901
66NEK60.79678560
67KSR10.77300942
68MUSK0.76490825
69LMTK20.76185692
70STK390.74978352
71SGK2230.73533261
72SGK4940.73533261
73TNIK0.71804542
74CAMK1G0.71689451
75CAMK2A0.70749874
76CAMK2B0.67886767
77IRAK10.66571496
78DYRK30.65477401
79CDK50.64919095
80SGK30.64477482
81WNK10.64175904
82MAP2K40.63581173
83MAP3K130.61282338
84PRKCI0.61105070
85PDK10.59606827
86MAP3K20.58527689
87STK100.58292328
88PIK3CG0.56384049
89AURKA0.56071449
90KSR20.55801960
91MST1R0.54241917
92UHMK10.54237266
93BRSK20.53322778
94CDK190.51780473
95PHKG20.51102630
96PHKG10.51102630
97TRPM70.49569910
98EPHB20.49072914
99PRKCE0.48765418
100GRK10.48196751
101PRKCQ0.46176521
102STK38L0.46173597
103INSRR0.44273623
104PAK30.42341267
105MKNK20.41673614
106ROCK20.41365379
107WEE10.39986193
108DYRK20.39273243
109PLK30.39155672
110ERBB30.39031643
111BRSK10.38721908
112TBK10.37898767
113PRKCD0.37321587
114STK160.35879032
115ADRBK10.35875025
116TSSK60.35792207
117DYRK1A0.34691231
118FGFR20.33073276
119CAMK2G0.33071531
120CSNK1G20.32909121
121CAMK2D0.32260869
122PASK0.32129721
123PDPK10.31471549
124AKT20.29872453
125CDK180.29750068
126PLK40.29094773
127SIK20.28440554
128CAMK10.27956047
129RAF10.27130292
130MARK20.27097212
131PRKACA0.26319639
132PRKCZ0.26287813
133RPS6KA20.25981844
134FYN0.25680759
135ROCK10.25581795
136FER0.25034649
137RIPK10.24048311
138MAPK100.23521688
139CDK150.23364700
140SGK10.23112874
141PRKG10.22911269
142VRK10.22725239
143CHEK20.22623287
144RET0.21936167
145STK110.21736642
146PRKCA0.21563338
147MET0.21119550
148LATS10.21051286
149ABL10.20736693
150OXSR10.20028536
151NTRK10.20003365
152SRC0.19344793
153PLK10.18204234
154MAP3K60.18193958

Predicted pathways (KEGG)

RankGene SetZ-score
1Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009805.25383534
2Phenylalanine metabolism_Homo sapiens_hsa003604.56007520
3Chemical carcinogenesis_Homo sapiens_hsa052044.25693106
4Histidine metabolism_Homo sapiens_hsa003404.24360178
5Drug metabolism - cytochrome P450_Homo sapiens_hsa009824.03104680
6Olfactory transduction_Homo sapiens_hsa047404.01420747
7Tyrosine metabolism_Homo sapiens_hsa003503.57682503
8Nicotine addiction_Homo sapiens_hsa050333.09594330
9Vitamin B6 metabolism_Homo sapiens_hsa007502.94901024
10beta-Alanine metabolism_Homo sapiens_hsa004102.86199373
11Amphetamine addiction_Homo sapiens_hsa050312.83574686
12Insulin secretion_Homo sapiens_hsa049112.67953288
13Synaptic vesicle cycle_Homo sapiens_hsa047212.67277056
14Circadian entrainment_Homo sapiens_hsa047132.43155266
15Glutathione metabolism_Homo sapiens_hsa004802.39269920
16Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.33338087
17Morphine addiction_Homo sapiens_hsa050322.13761305
18Taste transduction_Homo sapiens_hsa047422.11759258
19Retinol metabolism_Homo sapiens_hsa008302.09691626
20Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.06259441
21Collecting duct acid secretion_Homo sapiens_hsa049662.04034713
22GABAergic synapse_Homo sapiens_hsa047272.03707568
23Long-term potentiation_Homo sapiens_hsa047202.01184124
24Renin secretion_Homo sapiens_hsa049242.00408325
25Glutamatergic synapse_Homo sapiens_hsa047242.00286988
26Caffeine metabolism_Homo sapiens_hsa002321.92417418
27Cocaine addiction_Homo sapiens_hsa050301.90626205
28Salivary secretion_Homo sapiens_hsa049701.83739820
29Phototransduction_Homo sapiens_hsa047441.77817005
30Dopaminergic synapse_Homo sapiens_hsa047281.76633205
31Dorso-ventral axis formation_Homo sapiens_hsa043201.68810306
32Calcium signaling pathway_Homo sapiens_hsa040201.64738811
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.60849150
34Type I diabetes mellitus_Homo sapiens_hsa049401.56297243
35Gastric acid secretion_Homo sapiens_hsa049711.53642941
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.53595022
37Aldosterone synthesis and secretion_Homo sapiens_hsa049251.52165576
38Huntingtons disease_Homo sapiens_hsa050161.50544883
39Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.46453674
40Tight junction_Homo sapiens_hsa045301.46286955
41Glucagon signaling pathway_Homo sapiens_hsa049221.42658223
42cAMP signaling pathway_Homo sapiens_hsa040241.42161172
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.38330210
44Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.38323868
45Steroid hormone biosynthesis_Homo sapiens_hsa001401.36808217
46Estrogen signaling pathway_Homo sapiens_hsa049151.33200311
47Vibrio cholerae infection_Homo sapiens_hsa051101.31775255
48Cholinergic synapse_Homo sapiens_hsa047251.27844756
49Basal transcription factors_Homo sapiens_hsa030221.27363819
50Serotonergic synapse_Homo sapiens_hsa047261.25922771
51Oocyte meiosis_Homo sapiens_hsa041141.24460471
52ABC transporters_Homo sapiens_hsa020101.23281720
53Basal cell carcinoma_Homo sapiens_hsa052171.22530388
54Oxytocin signaling pathway_Homo sapiens_hsa049211.17834659
55Peroxisome_Homo sapiens_hsa041461.17465736
56Notch signaling pathway_Homo sapiens_hsa043301.13936914
57cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08136739
58Circadian rhythm_Homo sapiens_hsa047101.06445527
59Vascular smooth muscle contraction_Homo sapiens_hsa042701.04340648
60Fatty acid degradation_Homo sapiens_hsa000711.01304436
61Regulation of autophagy_Homo sapiens_hsa041400.99101972
62GnRH signaling pathway_Homo sapiens_hsa049120.99075280
63Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.98859858
64Glycerophospholipid metabolism_Homo sapiens_hsa005640.97813132
65Phosphatidylinositol signaling system_Homo sapiens_hsa040700.94618695
66Long-term depression_Homo sapiens_hsa047300.93016080
67Thyroid hormone synthesis_Homo sapiens_hsa049180.92260737
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.91958155
69Gap junction_Homo sapiens_hsa045400.91573974
70Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.90772525
71Rheumatoid arthritis_Homo sapiens_hsa053230.89451817
72Maturity onset diabetes of the young_Homo sapiens_hsa049500.88215287
73Purine metabolism_Homo sapiens_hsa002300.87905558
74Ether lipid metabolism_Homo sapiens_hsa005650.86784261
75Cardiac muscle contraction_Homo sapiens_hsa042600.83169242
76Linoleic acid metabolism_Homo sapiens_hsa005910.79846884
77alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.79341167
78Melanogenesis_Homo sapiens_hsa049160.79099349
79Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.76705187
80Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.76318252
81Starch and sucrose metabolism_Homo sapiens_hsa005000.75889551
82Carbohydrate digestion and absorption_Homo sapiens_hsa049730.75237709
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74869665
84Pancreatic secretion_Homo sapiens_hsa049720.73885621
85Type II diabetes mellitus_Homo sapiens_hsa049300.73706558
86Primary bile acid biosynthesis_Homo sapiens_hsa001200.72533140
87Oxidative phosphorylation_Homo sapiens_hsa001900.71592335
88Fanconi anemia pathway_Homo sapiens_hsa034600.69632237
89Hippo signaling pathway_Homo sapiens_hsa043900.69130941
90Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67049754
91Pyruvate metabolism_Homo sapiens_hsa006200.64843515
92Butanoate metabolism_Homo sapiens_hsa006500.63039106
93SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62911004
94Fatty acid biosynthesis_Homo sapiens_hsa000610.61833913
95Ovarian steroidogenesis_Homo sapiens_hsa049130.61241262
96Alzheimers disease_Homo sapiens_hsa050100.60935020
97Prion diseases_Homo sapiens_hsa050200.59372562
98Adherens junction_Homo sapiens_hsa045200.59089496
99Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58505449
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57910249
101Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57658729
102Steroid biosynthesis_Homo sapiens_hsa001000.56063094
103Alcoholism_Homo sapiens_hsa050340.55827452
104Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55643304
105Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.55564038
106Inositol phosphate metabolism_Homo sapiens_hsa005620.53963555
107Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.52365029
108Glycosaminoglycan degradation_Homo sapiens_hsa005310.52286722
109Axon guidance_Homo sapiens_hsa043600.52011294
110Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50357890
111Wnt signaling pathway_Homo sapiens_hsa043100.50080309
112Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49941584
113Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.48700193
114Mineral absorption_Homo sapiens_hsa049780.48104307
115Sphingolipid metabolism_Homo sapiens_hsa006000.47602495
116Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42901484
117Leukocyte transendothelial migration_Homo sapiens_hsa046700.42578149
118Parkinsons disease_Homo sapiens_hsa050120.42493779
119Drug metabolism - other enzymes_Homo sapiens_hsa009830.40717853
120Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40556297
121Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.39845337
122ErbB signaling pathway_Homo sapiens_hsa040120.38329909
123MAPK signaling pathway_Homo sapiens_hsa040100.35702687
124Pentose phosphate pathway_Homo sapiens_hsa000300.34617264
125Arachidonic acid metabolism_Homo sapiens_hsa005900.33809092
126Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33521235
127Metabolic pathways_Homo sapiens_hsa011000.33342761
128Hepatitis C_Homo sapiens_hsa051600.33311499
129PPAR signaling pathway_Homo sapiens_hsa033200.33214888
130Graft-versus-host disease_Homo sapiens_hsa053320.32840190
131Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.32782409
132Nitrogen metabolism_Homo sapiens_hsa009100.32150314
133Bile secretion_Homo sapiens_hsa049760.32010530
134Arginine and proline metabolism_Homo sapiens_hsa003300.31589348
135Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.30817278
136Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.30737791
137Complement and coagulation cascades_Homo sapiens_hsa046100.29171372
138Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.27494325
139Hedgehog signaling pathway_Homo sapiens_hsa043400.27393117
140Transcriptional misregulation in cancer_Homo sapiens_hsa052020.27023354
141Glycerolipid metabolism_Homo sapiens_hsa005610.26051914
142Phospholipase D signaling pathway_Homo sapiens_hsa040720.24595170
143Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.23046049
144African trypanosomiasis_Homo sapiens_hsa051430.22262954
145Tryptophan metabolism_Homo sapiens_hsa003800.21652617
146Choline metabolism in cancer_Homo sapiens_hsa052310.21353456
147Amoebiasis_Homo sapiens_hsa051460.18808954
148Dilated cardiomyopathy_Homo sapiens_hsa054140.18600267
149Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.12007840
150Phagosome_Homo sapiens_hsa041450.11594547
151Vitamin digestion and absorption_Homo sapiens_hsa049770.10857644

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