DRC3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of cilium movement (GO:0003352)8.74340860
2left/right pattern formation (GO:0060972)8.28701851
3left/right axis specification (GO:0070986)7.04585021
4intraciliary transport (GO:0042073)6.67053813
5ventricular system development (GO:0021591)6.62632169
6cilium organization (GO:0044782)6.42105576
7microtubule bundle formation (GO:0001578)6.33762596
8primary alcohol catabolic process (GO:0034310)6.33540135
9cilium assembly (GO:0042384)6.24456299
10vitamin transmembrane transport (GO:0035461)6.15592240
11protein localization to cilium (GO:0061512)5.58088233
12ethanol metabolic process (GO:0006067)5.32726952
13regulation of microtubule-based movement (GO:0060632)5.31156748
14diterpenoid biosynthetic process (GO:0016102)5.28363090
15cellular component assembly involved in morphogenesis (GO:0010927)4.94113636
16cilium morphogenesis (GO:0060271)4.90758792
17pyrimidine-containing compound transmembrane transport (GO:0072531)4.79799924
18response to xenobiotic stimulus (GO:0009410)4.79106779
19centriole assembly (GO:0098534)4.74983819
20one-carbon compound transport (GO:0019755)4.69314127
21microtubule-based movement (GO:0007018)4.55906491
22negative regulation of T cell differentiation in thymus (GO:0033085)4.50173828
23cell projection assembly (GO:0030031)4.37175916
24lung epithelium development (GO:0060428)4.32581434
25tolerance induction (GO:0002507)4.30110934
26negative regulation of immunoglobulin mediated immune response (GO:0002890)4.23283148
27negative regulation of B cell mediated immunity (GO:0002713)4.23283148
28regulation of germinal center formation (GO:0002634)4.00528922
29terpenoid biosynthetic process (GO:0016114)3.98550250
30ethanol oxidation (GO:0006069)3.93382501
31retinoic acid metabolic process (GO:0042573)3.89959948
32negative regulation of humoral immune response (GO:0002921)3.89794971
33glomerular epithelial cell development (GO:0072310)3.86786021
34regulation of interleukin-5 production (GO:0032674)3.82239857
35exogenous drug catabolic process (GO:0042738)3.74327168
36sperm capacitation (GO:0048240)3.72280758
37nucleoside diphosphate phosphorylation (GO:0006165)3.67994928
38cytoplasmic microtubule organization (GO:0031122)3.59990156
39lateral ventricle development (GO:0021670)3.56237379
40establishment of apical/basal cell polarity (GO:0035089)3.40709695
41microtubule depolymerization (GO:0007019)3.39799067
42establishment or maintenance of monopolar cell polarity (GO:0061339)3.35056918
43establishment of monopolar cell polarity (GO:0061162)3.35056918
44microtubule polymerization or depolymerization (GO:0031109)3.28354852
45determination of left/right symmetry (GO:0007368)3.26674608
46sperm motility (GO:0030317)3.25477790
47regulation of interleukin-13 production (GO:0032656)3.25340559
48positive regulation of tolerance induction (GO:0002645)3.24283405
49retinal rod cell development (GO:0046548)3.20166646
50smoothened signaling pathway (GO:0007224)3.17521531
51glutathione derivative biosynthetic process (GO:1901687)3.12928819
52glutathione derivative metabolic process (GO:1901685)3.12928819
53determination of bilateral symmetry (GO:0009855)3.12471589
54drug catabolic process (GO:0042737)3.10175053
55photoreceptor cell maintenance (GO:0045494)3.09567073
56nonmotile primary cilium assembly (GO:0035058)3.06620558
57specification of symmetry (GO:0009799)3.03645865
58aldehyde catabolic process (GO:0046185)3.02964996
59axonemal dynein complex assembly (GO:0070286)20.1882077
60retinol metabolic process (GO:0042572)2.96009647
61centriole replication (GO:0007099)2.95140692
62cornea development in camera-type eye (GO:0061303)2.93453796
63lateral sprouting from an epithelium (GO:0060601)2.92861166
64primary alcohol metabolic process (GO:0034308)2.92250281
65negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.79926566
66regulation of collateral sprouting (GO:0048670)2.78008757
67carnitine metabolic process (GO:0009437)2.77221124
68organelle assembly (GO:0070925)2.75758801
69microtubule-based process (GO:0007017)2.74140581
70positive regulation of smoothened signaling pathway (GO:0045880)2.73893963
71establishment of planar polarity (GO:0001736)2.72389902
72establishment of tissue polarity (GO:0007164)2.72389902
73retinal cone cell development (GO:0046549)2.72294728
74negative regulation of inclusion body assembly (GO:0090084)2.69995125
75hydrogen peroxide biosynthetic process (GO:0050665)2.67332808
76O-glycan processing (GO:0016266)2.64536512
77phosphatidylcholine biosynthetic process (GO:0006656)2.61054024
78regulation of microtubule depolymerization (GO:0031114)2.60974969
79protein polyglutamylation (GO:0018095)2.59733048
80sialylation (GO:0097503)2.57907027
81phosphatidylethanolamine biosynthetic process (GO:0006646)2.45577937
82neurotransmitter biosynthetic process (GO:0042136)2.44455335
83carnitine transmembrane transport (GO:1902603)2.43138019
84reactive oxygen species biosynthetic process (GO:1903409)2.40656336
85regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.40010521
86excretion (GO:0007588)2.39995626
87neural tube formation (GO:0001841)2.38617123
88phosphatidylethanolamine metabolic process (GO:0046337)2.36614049
89intra-S DNA damage checkpoint (GO:0031573)2.35109365
90organic cation transport (GO:0015695)2.32738181
91oligosaccharide biosynthetic process (GO:0009312)2.32442042
92heart looping (GO:0001947)2.31728784
93calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.30350252
94neurotransmitter metabolic process (GO:0042133)2.30019120
95cilium or flagellum-dependent cell motility (GO:0001539)17.5498909
96cilium movement (GO:0003341)15.2249393
97epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)14.4070710
98motile cilium assembly (GO:0044458)13.7638751
99epithelial cilium movement (GO:0003351)13.3233567
100axoneme assembly (GO:0035082)10.3628923

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1DROSHA_22980978_ChIP-Seq_HELA_Human3.02421364
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.01117198
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.86793548
4VDR_22108803_ChIP-Seq_LS180_Human2.85259649
5FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.81029479
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.53876621
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.37229031
8PIAS1_25552417_ChIP-Seq_VCAP_Human2.20160295
9ZNF274_21170338_ChIP-Seq_K562_Hela1.93707538
10NR3C1_21868756_ChIP-Seq_MCF10A_Human1.85824522
11AHR_22903824_ChIP-Seq_MCF-7_Human1.82621139
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.73757687
13ESR1_20079471_ChIP-ChIP_T-47D_Human1.66332416
14ARNT_22903824_ChIP-Seq_MCF-7_Human1.64875004
15CTBP2_25329375_ChIP-Seq_LNCAP_Human1.64009369
16SMAD4_21799915_ChIP-Seq_A2780_Human1.63927003
17CTBP1_25329375_ChIP-Seq_LNCAP_Human1.60480727
18FOXM1_26456572_ChIP-Seq_MCF-7_Human1.56397729
19TOP2B_26459242_ChIP-Seq_MCF-7_Human1.56334262
20BCAT_22108803_ChIP-Seq_LS180_Human1.55237271
21PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.51748046
22AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.51230424
23TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.49953045
24POU3F2_20337985_ChIP-ChIP_501MEL_Human1.49496118
25FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.47240041
26AR_21572438_ChIP-Seq_LNCaP_Human1.44168397
27ETV1_20927104_ChIP-Seq_GIST48_Human1.42304746
28TP63_23658742_ChIP-Seq_EP156T_Human1.41216018
29ER_23166858_ChIP-Seq_MCF-7_Human1.40568845
30EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.40201914
31AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.39137117
32SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39003765
33SMRT_27268052_Chip-Seq_Bcells_Human1.38515682
34STAT3_23295773_ChIP-Seq_U87_Human1.38122373
35TP53_18474530_ChIP-ChIP_U2OS_Human1.36112421
36TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.35576336
37PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.35176123
38PHF8_20622853_ChIP-Seq_HELA_Human1.33286047
39ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.33094297
40SMAD3_21741376_ChIP-Seq_EPCs_Human1.32494733
41TCF4_22108803_ChIP-Seq_LS180_Human1.30995613
42IGF1R_20145208_ChIP-Seq_DFB_Human1.30141529
43STAT1_20625510_ChIP-Seq_HELA_Human1.29692692
44GBX2_23144817_ChIP-Seq_PC3_Human1.28381817
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28352086
46CBP_20019798_ChIP-Seq_JUKART_Human1.28352086
47ZNF217_24962896_ChIP-Seq_MCF-7_Human1.26665441
48ZFP57_27257070_Chip-Seq_ESCs_Mouse1.26206479
49CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.25955970
50FUS_26573619_Chip-Seq_HEK293_Human1.25599712
51CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25280440
52FOXA1_25552417_ChIP-Seq_VCAP_Human1.25217542
53TCF4_23295773_ChIP-Seq_U87_Human1.25017158
54TAF15_26573619_Chip-Seq_HEK293_Human1.24531674
55TDRD3_21172665_ChIP-Seq_MCF-7_Human1.23137849
56MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22849377
57SALL1_21062744_ChIP-ChIP_HESCs_Human1.20787433
58PCGF2_27294783_Chip-Seq_ESCs_Mouse1.20771188
59FOXA1_27270436_Chip-Seq_PROSTATE_Human1.20299577
60FOXA1_25329375_ChIP-Seq_VCAP_Human1.20299577
61HNFA_21074721_ChIP-Seq_CACO-2_Human1.20232787
62CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.19133614
63RBPJ_21746931_ChIP-Seq_IB4_Human1.18943389
64SMAD4_21741376_ChIP-Seq_EPCs_Human1.18932133
65TP53_16413492_ChIP-PET_HCT116_Human1.16136054
66P300_19829295_ChIP-Seq_ESCs_Human1.16025812
67EWS_26573619_Chip-Seq_HEK293_Human1.15935520
68TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15557795
69POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15557795
70CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.15155852
71AR_20517297_ChIP-Seq_VCAP_Human1.14703560
72SMAD3_21741376_ChIP-Seq_HESCs_Human1.13960012
73CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.13693101
74TBL1_22424771_ChIP-Seq_293T_Human1.13521688
75NFYA_21822215_ChIP-Seq_K562_Human1.13212674
76RUNX2_22187159_ChIP-Seq_PCA_Human1.12851547
77ESR1_21235772_ChIP-Seq_MCF-7_Human1.12691579
78PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.12388787
79CBX2_22325352_ChIP-Seq_293T-Rex_Human1.11767396
80NFYB_21822215_ChIP-Seq_K562_Human1.11525494
81FLI1_27457419_Chip-Seq_LIVER_Mouse1.09923481
82AR_25329375_ChIP-Seq_VCAP_Human1.08848372
83CTNNB1_20460455_ChIP-Seq_HCT116_Human1.07355958
84NCOR_22424771_ChIP-Seq_293T_Human1.04557139
85GATA6_21074721_ChIP-Seq_CACO-2_Human1.03875135
86TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03401196
87TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.03001131
88PRDM14_20953172_ChIP-Seq_ESCs_Human1.02832004
89FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.02434685
90CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.01628333
91CDX2_22108803_ChIP-Seq_LS180_Human1.01493524
92FOXA1_21572438_ChIP-Seq_LNCaP_Human1.01047670
93BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00982044
94KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00647358
95CEBPB_22108803_ChIP-Seq_LS180_Human0.99478969
96GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.99268038
97SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.98906847
98TRIM28_21343339_ChIP-Seq_HEK293_Human0.98243292
99TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97556464
100RAD21_21589869_ChIP-Seq_MESCs_Mouse0.97439632

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology6.39931261
2MP0008875_abnormal_xenobiotic_pharmacok6.31187904
3MP0001984_abnormal_olfaction4.27274645
4MP0002132_abnormal_respiratory_system4.19544720
5MP0004043_abnormal_pH_regulation3.98983962
6MP0004133_heterotaxia3.37667529
7MP0009780_abnormal_chondrocyte_physiolo3.33664409
8MP0008789_abnormal_olfactory_epithelium3.32429298
9MP0002277_abnormal_respiratory_mucosa3.23913095
10MP0000566_synostosis2.57921912
11MP0000383_abnormal_hair_follicle2.54921136
12MP0005394_taste/olfaction_phenotype2.26648939
13MP0005499_abnormal_olfactory_system2.26648939
14MP0002282_abnormal_trachea_morphology2.07998747
15MP0010678_abnormal_skin_adnexa2.02422891
16MP0005623_abnormal_meninges_morphology1.99078491
17MP0003878_abnormal_ear_physiology1.85426078
18MP0005377_hearing/vestibular/ear_phenot1.85426078
19MP0002160_abnormal_reproductive_system1.82603661
20MP0002909_abnormal_adrenal_gland1.81899316
21MP0002168_other_aberrant_phenotype1.73310183
22MP0002876_abnormal_thyroid_physiology1.71808229
23MP0004019_abnormal_vitamin_homeostasis1.68238975
24MP0005551_abnormal_eye_electrophysiolog1.66439115
25MP0002638_abnormal_pupillary_reflex1.58069491
26MP0001346_abnormal_lacrimal_gland1.57613068
27MP0009046_muscle_twitch1.53400578
28MP0005253_abnormal_eye_physiology1.49798354
29MP0001765_abnormal_ion_homeostasis1.46280673
30MP0005646_abnormal_pituitary_gland1.40667579
31MP0002735_abnormal_chemical_nociception1.40034017
32MP0002734_abnormal_mechanical_nocicepti1.39660930
33MP0003656_abnormal_erythrocyte_physiolo1.36230032
34MP0001485_abnormal_pinna_reflex1.30972404
35MP0003136_yellow_coat_color1.30573259
36MP0005395_other_phenotype1.23371874
37MP0005248_abnormal_Harderian_gland1.22135283
38MP0002233_abnormal_nose_morphology1.12719776
39MP0005636_abnormal_mineral_homeostasis1.11207974
40MP0000631_abnormal_neuroendocrine_gland1.10952076
41MP0003698_abnormal_male_reproductive1.07942530
42MP0002102_abnormal_ear_morphology1.05155751
43MP0008872_abnormal_physiological_respon1.04823337
44MP0003195_calcinosis1.04607413
45MP0005389_reproductive_system_phenotype1.04406950
46MP0001929_abnormal_gametogenesis1.01248217
47MP0005083_abnormal_biliary_tract0.99527664
48MP0005645_abnormal_hypothalamus_physiol0.98645576
49MP0005220_abnormal_exocrine_pancreas0.90804849
50MP0009745_abnormal_behavioral_response0.89989543
51MP0000026_abnormal_inner_ear0.87214932
52MP0001324_abnormal_eye_pigmentation0.86833877
53MP0001970_abnormal_pain_threshold0.86828958
54MP0005195_abnormal_posterior_eye0.85206060
55MP0001968_abnormal_touch/_nociception0.84903573
56MP0002229_neurodegeneration0.81461865
57MP0002557_abnormal_social/conspecific_i0.81376769
58MP0002928_abnormal_bile_duct0.80945313
59MP0004885_abnormal_endolymph0.80789931
60MP0001486_abnormal_startle_reflex0.80761729
61MP0005408_hypopigmentation0.78726693
62MP0002572_abnormal_emotion/affect_behav0.77459177
63MP0000465_gastrointestinal_hemorrhage0.76873261
64MP0005310_abnormal_salivary_gland0.75203517
65MP0001944_abnormal_pancreas_morphology0.73739145
66MP0001293_anophthalmia0.73484273
67MP0005391_vision/eye_phenotype0.72627274
68MP0002249_abnormal_larynx_morphology0.72006153
69MP0000681_abnormal_thyroid_gland0.71509116
70MP0001963_abnormal_hearing_physiology0.71158938
71MP0000427_abnormal_hair_cycle0.71077387
72MP0009643_abnormal_urine_homeostasis0.69559448
73MP0005365_abnormal_bile_salt0.69290746
74MP0000372_irregular_coat_pigmentation0.68138228
75MP0001270_distended_abdomen0.68068859
76MP0005085_abnormal_gallbladder_physiolo0.67789137
77MP0003937_abnormal_limbs/digits/tail_de0.67141687
78MP0000678_abnormal_parathyroid_gland0.66178168
79MP0003718_maternal_effect0.66055349
80MP0001502_abnormal_circadian_rhythm0.64031102
81MP0008995_early_reproductive_senescence0.63700202
82MP0002272_abnormal_nervous_system0.62858567
83MP0010030_abnormal_orbit_morphology0.61001808
84MP0001664_abnormal_digestion0.59972164
85MP0001986_abnormal_taste_sensitivity0.59884621
86MP0006072_abnormal_retinal_apoptosis0.59289182
87MP0005165_increased_susceptibility_to0.58396056
88MP0002136_abnormal_kidney_physiology0.56232909
89MP0004883_abnormal_blood_vessel0.55745614
90MP0003880_abnormal_central_pattern0.53514693
91MP0002752_abnormal_somatic_nervous0.53066116
92MP0006036_abnormal_mitochondrial_physio0.52395589
93MP0001529_abnormal_vocalization0.51738792
94MP0003633_abnormal_nervous_system0.51649546
95MP0003890_abnormal_embryonic-extraembry0.51331842
96MP0006276_abnormal_autonomic_nervous0.51152563
97MP0002098_abnormal_vibrissa_morphology0.51053401
98MP0002067_abnormal_sensory_capabilities0.50329416
99MP0009703_decreased_birth_body0.50303510
100MP0000955_abnormal_spinal_cord0.50107546

Predicted human phenotypes

RankGene SetZ-score
1Rhinitis (HP:0012384)9.65154318
2Chronic bronchitis (HP:0004469)7.32866094
3Bronchiectasis (HP:0002110)7.04898995
4Nasal polyposis (HP:0100582)5.99749659
5Abnormality of the nasal mucosa (HP:0000433)4.90280759
6Recurrent sinusitis (HP:0011108)4.21168714
7Pancreatic fibrosis (HP:0100732)4.10623646
8Bronchitis (HP:0012387)4.10208966
9True hermaphroditism (HP:0010459)4.01700655
10Infertility (HP:0000789)3.98842171
11Chronic sinusitis (HP:0011109)3.96469467
12Occipital encephalocele (HP:0002085)3.65056330
13Male infertility (HP:0003251)3.57924779
14Pancreatic cysts (HP:0001737)3.56306733
15Recurrent otitis media (HP:0000403)3.52821025
16Nephronophthisis (HP:0000090)3.39955775
17Molar tooth sign on MRI (HP:0002419)3.39640457
18Abnormality of midbrain morphology (HP:0002418)3.39640457
19Cystic liver disease (HP:0006706)3.19974295
20Chronic otitis media (HP:0000389)3.09895564
21Chronic hepatic failure (HP:0100626)2.94324354
22Postaxial foot polydactyly (HP:0001830)2.72457381
23Abnormality of the renal medulla (HP:0100957)2.70834778
24Hyperactive renin-angiotensin system (HP:0000841)2.65270528
25Atelectasis (HP:0100750)2.54474895
26Medial flaring of the eyebrow (HP:0010747)2.51460531
27Tubulointerstitial nephritis (HP:0001970)2.50460740
28Congenital hepatic fibrosis (HP:0002612)2.39192518
29Aplasia/Hypoplasia of the tongue (HP:0010295)2.28688306
30Anencephaly (HP:0002323)2.28515482
31Gait imbalance (HP:0002141)2.24871990
32Congenital primary aphakia (HP:0007707)2.23936996
33Male pseudohermaphroditism (HP:0000037)2.18121326
34Tubular atrophy (HP:0000092)2.10993917
35Aplasia/Hypoplasia of the spleen (HP:0010451)2.06146895
36Asplenia (HP:0001746)2.04764150
37Nephrogenic diabetes insipidus (HP:0009806)2.03131145
38Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.8760267
39Abnormal respiratory epithelium morphology (HP:0012253)10.9153019
40Abnormal respiratory motile cilium morphology (HP:0005938)10.9153019
41Dynein arm defect of respiratory motile cilia (HP:0012255)10.8040760
42Absent/shortened dynein arms (HP:0200106)10.8040760
43Abnormal respiratory motile cilium physiology (HP:0012261)10.5633527
44Abnormal ciliary motility (HP:0012262)10.4621334
45Sclerocornea (HP:0000647)1.97638722
46Decreased circulating renin level (HP:0003351)1.97357961
47Furrowed tongue (HP:0000221)1.91400536
48Bell-shaped thorax (HP:0001591)1.90289328
49Postaxial hand polydactyly (HP:0001162)1.88723845
50Recurrent bronchitis (HP:0002837)1.88382190
51Oculomotor apraxia (HP:0000657)1.83152263
52Absent rod-and cone-mediated responses on ERG (HP:0007688)1.80178064
53Renal salt wasting (HP:0000127)1.73511812
54Nephropathy (HP:0000112)1.73021660
55Absent frontal sinuses (HP:0002688)1.67843359
56Genital tract atresia (HP:0001827)1.65093549
57Vaginal atresia (HP:0000148)1.62968499
58Preaxial hand polydactyly (HP:0001177)1.59517754
59Decreased central vision (HP:0007663)1.59436775
60Tubulointerstitial abnormality (HP:0001969)1.56491665
61Poor coordination (HP:0002370)1.53003273
62Abnormal drinking behavior (HP:0030082)1.48180602
63Polydipsia (HP:0001959)1.48180602
64Hyperaldosteronism (HP:0000859)1.47053594
65Hyperkalemia (HP:0002153)1.46363455
66Abnormality of the renal cortex (HP:0011035)1.46036708
67Abnormal rod and cone electroretinograms (HP:0008323)1.45906495
68Abnormality of renin-angiotensin system (HP:0000847)1.43234850
69Median cleft lip (HP:0000161)1.40812549
70Absent speech (HP:0001344)1.37537978
71Bile duct proliferation (HP:0001408)1.35369235
72Abnormal biliary tract physiology (HP:0012439)1.35369235
73Hypokalemic alkalosis (HP:0001949)1.35346092
74Stage 5 chronic kidney disease (HP:0003774)1.34886902
75Abnormality of chloride homeostasis (HP:0011422)1.25560295
76Retinitis pigmentosa (HP:0000510)1.23567924
77Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.23251761
78Short thorax (HP:0010306)1.22527220
79Abnormality of macular pigmentation (HP:0008002)1.21233333
80Supernumerary spleens (HP:0009799)1.18234842
81Tubulointerstitial fibrosis (HP:0005576)1.16638452
82Narrow forehead (HP:0000341)1.14331685
83Cone-rod dystrophy (HP:0000548)1.14093876
84Prominent nasal bridge (HP:0000426)1.13520500
85Hip dysplasia (HP:0001385)1.11078574
86Fetal akinesia sequence (HP:0001989)1.08698567
87Multicystic kidney dysplasia (HP:0000003)1.08334483
88Aganglionic megacolon (HP:0002251)1.07175180
89Bifid scrotum (HP:0000048)1.06067652
90Abnormality of permanent molar morphology (HP:0011071)1.04406319
91Abnormality of the dental root (HP:0006486)1.04406319
92Taurodontia (HP:0000679)1.04406319
93Carpal bone hypoplasia (HP:0001498)1.03099928
94Aplasia/Hypoplasia of the lens (HP:0008063)1.02297044
95Abnormality of the frontal sinuses (HP:0002687)1.00805546
96Polyuria (HP:0000103)1.00732485
97Disproportionate short-trunk short stature (HP:0003521)1.00017841
98Broad foot (HP:0001769)0.96962905
99Glucose intolerance (HP:0000833)0.96930691
100Highly arched eyebrow (HP:0002553)0.96174923

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST45.27982643
2EPHA23.41112352
3FRK3.03920128
4BCR2.10846930
5NME12.07397109
6MAPK1510.5805535
7MAPKAPK31.98348736
8PNCK1.83053761
9MAP4K21.72535926
10MAP3K41.72187402
11PTK2B1.63916734
12WNK31.59614562
13MAP3K21.52400427
14ADRBK21.45974932
15ERBB31.35981848
16MAPK131.34091365
17TLK11.30302062
18STK241.17573148
19GRK11.16843659
20EPHA31.13201016
21MAP2K71.07486730
22TTK1.04561411
23TRPM71.03152347
24CASK0.97740507
25TRIM280.94983657
26INSRR0.94257816
27STK160.93349840
28BMPR1B0.93076601
29BRSK20.91100634
30MAP3K70.90304093
31PINK10.89096410
32CSK0.86521531
33IRAK10.86150928
34PRKCI0.83205588
35NEK60.81386561
36FGFR20.81354175
37OXSR10.80473994
38EPHA40.78789941
39CAMKK20.78076984
40ERBB20.74254298
41LATS10.74174958
42MAP3K30.70284593
43ADRBK10.69112086
44MUSK0.68253247
45EEF2K0.67446170
46FER0.66762654
47ACVR1B0.65274909
48MARK10.64931094
49STK100.63745181
50CAMKK10.63284872
51PRKCQ0.58680718
52NTRK30.58009131
53PAK30.57688806
54STK390.57111638
55STK380.55895209
56PRKAA20.54728437
57STK38L0.54331431
58NLK0.51089241
59PRKCE0.50256006
60DYRK1A0.49772939
61EPHB10.46613727
62MAP2K40.45802410
63LRRK20.45669417
64PRKACA0.42637563
65MAPKAPK50.41922542
66DYRK20.38727139
67CSNK1G20.38558971
68TBK10.38275740
69ABL10.37799329
70PRKCZ0.37077272
71CAMK2A0.36295707
72SGK10.36053667
73PRKCD0.34879003
74MARK20.31776951
75PRKCA0.31558072
76RIPK40.31296169
77HIPK20.30830303
78PRKAA10.29361045
79WNK40.27691651
80NUAK10.27404033
81PASK0.27300777
82MAP2K60.26392541
83STK110.25968113
84CSNK1A1L0.25647553
85GRK60.25608105
86ROCK10.25134298
87CAMK2G0.24497099
88SMG10.24179305
89IGF1R0.23237494
90PRKCG0.22415632
91PKN10.21501743
92CSNK1G10.20974049
93DYRK1B0.20287053
94CSNK1G30.20252375
95PLK20.20129822
96TEC0.19412530
97CSNK1A10.19098501
98MAP3K120.18827632
99PRKG10.18655157
100SGK20.17727782

Predicted pathways (KEGG)

RankGene SetZ-score
1Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009804.80077055
2Chemical carcinogenesis_Homo sapiens_hsa052044.09269368
3Histidine metabolism_Homo sapiens_hsa003403.95881707
4Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.92230360
5Phenylalanine metabolism_Homo sapiens_hsa003603.70950013
6Tyrosine metabolism_Homo sapiens_hsa003503.11195090
7beta-Alanine metabolism_Homo sapiens_hsa004102.84971551
8Huntingtons disease_Homo sapiens_hsa050162.66998934
9Caffeine metabolism_Homo sapiens_hsa002322.59985488
10Linoleic acid metabolism_Homo sapiens_hsa005912.56202914
11Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.14580063
12Retinol metabolism_Homo sapiens_hsa008302.14392525
13Glutathione metabolism_Homo sapiens_hsa004802.12825323
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.83848333
15ABC transporters_Homo sapiens_hsa020101.75432738
16Steroid hormone biosynthesis_Homo sapiens_hsa001401.58186874
17Phototransduction_Homo sapiens_hsa047441.57641150
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.53695079
19Sphingolipid metabolism_Homo sapiens_hsa006001.51825245
20Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.49672291
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.45829371
22Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.43755206
23Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.40356926
24Peroxisome_Homo sapiens_hsa041461.35614709
25Fatty acid degradation_Homo sapiens_hsa000711.28915409
26Salivary secretion_Homo sapiens_hsa049701.25980672
27Butanoate metabolism_Homo sapiens_hsa006501.25018459
28Taste transduction_Homo sapiens_hsa047421.24615676
29Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.22391226
30Nicotine addiction_Homo sapiens_hsa050331.21388099
31Circadian rhythm_Homo sapiens_hsa047101.19701242
32Arachidonic acid metabolism_Homo sapiens_hsa005901.17129946
33alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.17032891
34Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.14303028
35Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.12497342
36Collecting duct acid secretion_Homo sapiens_hsa049661.09930172
37Olfactory transduction_Homo sapiens_hsa047401.06539502
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.06145725
39Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.02706715
40Tight junction_Homo sapiens_hsa045300.96386811
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.94230284
42Tryptophan metabolism_Homo sapiens_hsa003800.88181762
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.86590000
44Carbohydrate digestion and absorption_Homo sapiens_hsa049730.80732452
45Nitrogen metabolism_Homo sapiens_hsa009100.79613283
46Regulation of autophagy_Homo sapiens_hsa041400.78997850
47Ether lipid metabolism_Homo sapiens_hsa005650.78280187
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.76001906
49Maturity onset diabetes of the young_Homo sapiens_hsa049500.71586634
50Glycerophospholipid metabolism_Homo sapiens_hsa005640.71553442
51Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69051798
52Primary bile acid biosynthesis_Homo sapiens_hsa001200.68684974
53Hedgehog signaling pathway_Homo sapiens_hsa043400.67368213
54Starch and sucrose metabolism_Homo sapiens_hsa005000.62389928
55Serotonergic synapse_Homo sapiens_hsa047260.62347890
56Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62237746
57Propanoate metabolism_Homo sapiens_hsa006400.58379199
58Drug metabolism - other enzymes_Homo sapiens_hsa009830.56188197
59Cocaine addiction_Homo sapiens_hsa050300.54324128
60Ovarian steroidogenesis_Homo sapiens_hsa049130.52858066
61Calcium signaling pathway_Homo sapiens_hsa040200.49756432
62Type I diabetes mellitus_Homo sapiens_hsa049400.49253680
63Metabolic pathways_Homo sapiens_hsa011000.48651094
64Choline metabolism in cancer_Homo sapiens_hsa052310.47313641
65Glycerolipid metabolism_Homo sapiens_hsa005610.45254851
66Intestinal immune network for IgA production_Homo sapiens_hsa046720.41279977
67Amphetamine addiction_Homo sapiens_hsa050310.38819348
68Basal cell carcinoma_Homo sapiens_hsa052170.38743649
69cAMP signaling pathway_Homo sapiens_hsa040240.38135606
70Oxidative phosphorylation_Homo sapiens_hsa001900.33505538
71Asthma_Homo sapiens_hsa053100.32099397
72Insulin secretion_Homo sapiens_hsa049110.30267640
73Protein export_Homo sapiens_hsa030600.30024008
74Glutamatergic synapse_Homo sapiens_hsa047240.29581390
75Cyanoamino acid metabolism_Homo sapiens_hsa004600.28957648
76Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.28548249
77Steroid biosynthesis_Homo sapiens_hsa001000.27584563
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.26995244
79Hematopoietic cell lineage_Homo sapiens_hsa046400.26124465
80Arginine and proline metabolism_Homo sapiens_hsa003300.25429085
81Cardiac muscle contraction_Homo sapiens_hsa042600.25021809
82Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.24757207
83Glycosaminoglycan degradation_Homo sapiens_hsa005310.24535779
84Circadian entrainment_Homo sapiens_hsa047130.24054849
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.23137233
86Purine metabolism_Homo sapiens_hsa002300.22937624
87PPAR signaling pathway_Homo sapiens_hsa033200.22651168
88Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.21618229
89Vitamin digestion and absorption_Homo sapiens_hsa049770.20765474
90Pancreatic secretion_Homo sapiens_hsa049720.18344431
91Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.17227286
92Allograft rejection_Homo sapiens_hsa053300.16549451
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.16547047
94Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.16517301
95Autoimmune thyroid disease_Homo sapiens_hsa053200.14703659
96Oxytocin signaling pathway_Homo sapiens_hsa049210.14588181
97Mineral absorption_Homo sapiens_hsa049780.14178171
98Basal transcription factors_Homo sapiens_hsa030220.14159058
99Axon guidance_Homo sapiens_hsa043600.13149958
100Complement and coagulation cascades_Homo sapiens_hsa046100.11936866

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