DRD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cerebellar granule cell differentiation (GO:0021707)7.28937382
2positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.98159427
3regulation of synapse structural plasticity (GO:0051823)5.80182767
4negative regulation of cytosolic calcium ion concentration (GO:0051481)5.68208688
5regulation of short-term neuronal synaptic plasticity (GO:0048172)5.52454548
6* synaptic transmission, dopaminergic (GO:0001963)5.50490374
7neurotransmitter-gated ion channel clustering (GO:0072578)5.47375810
8* prepulse inhibition (GO:0060134)5.24046833
9membrane depolarization during cardiac muscle cell action potential (GO:0086012)5.00488139
10synaptic vesicle maturation (GO:0016188)4.99932875
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.90944636
12* striatum development (GO:0021756)4.88849587
13synaptic vesicle exocytosis (GO:0016079)4.88269046
14vocalization behavior (GO:0071625)4.85471297
15negative regulation of synaptic transmission, glutamatergic (GO:0051967)4.81346945
16regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.76598199
17regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.64577729
18locomotory exploration behavior (GO:0035641)4.60579454
19regulation of glutamate receptor signaling pathway (GO:1900449)4.53843731
20regulation of long-term neuronal synaptic plasticity (GO:0048169)4.53196262
21regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.52921452
22regulation of synaptic vesicle exocytosis (GO:2000300)4.52281629
23protein localization to synapse (GO:0035418)4.49181367
24* neuron-neuron synaptic transmission (GO:0007270)4.41198373
25auditory behavior (GO:0031223)4.41104515
26cochlea development (GO:0090102)4.37598171
27positive regulation of synaptic transmission, GABAergic (GO:0032230)4.37121254
28cAMP catabolic process (GO:0006198)4.31744717
29response to histamine (GO:0034776)4.31718659
30* transmission of nerve impulse (GO:0019226)4.25631771
31positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.23929633
32cell differentiation in hindbrain (GO:0021533)4.22420608
33* response to amphetamine (GO:0001975)4.20302713
34positive regulation of neurotransmitter transport (GO:0051590)4.20149562
35adenosine receptor signaling pathway (GO:0001973)4.19991099
36regulation of neuronal synaptic plasticity (GO:0048168)4.18017254
37regulation of dendritic spine morphogenesis (GO:0061001)4.16952125
38G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.13159290
39ionotropic glutamate receptor signaling pathway (GO:0035235)4.11829388
40regulation of glutamate secretion (GO:0014048)4.11001636
41response to auditory stimulus (GO:0010996)4.09336921
42synaptic vesicle docking involved in exocytosis (GO:0016081)4.09127480
43glutamate receptor signaling pathway (GO:0007215)4.07468575
44* regulation of synaptic transmission, glutamatergic (GO:0051966)4.07241834
45synaptic transmission, glutamatergic (GO:0035249)4.04433726
46regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.04092362
47regulation of excitatory postsynaptic membrane potential (GO:0060079)4.03724094
48neurotransmitter secretion (GO:0007269)4.03567717
49sodium ion export (GO:0071436)4.01358059
50cellular potassium ion homeostasis (GO:0030007)4.00690465
51long-term memory (GO:0007616)3.99565163
52positive regulation of synapse maturation (GO:0090129)3.99216624
53serotonin metabolic process (GO:0042428)3.99162535
54* positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.98083010
55positive regulation of membrane potential (GO:0045838)3.96445274
56cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.94160824
57* dopamine receptor signaling pathway (GO:0007212)3.93434255
58presynaptic membrane organization (GO:0097090)3.91986291
59membrane hyperpolarization (GO:0060081)3.91615613
60regulation of female receptivity (GO:0045924)3.90618292
61regulation of synaptic vesicle transport (GO:1902803)3.90616375
62cerebellar Purkinje cell differentiation (GO:0021702)3.86181692
63neuron recognition (GO:0008038)3.85018644
64* behavioral response to cocaine (GO:0048148)3.84546745
65* adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.82871179
66cyclic nucleotide catabolic process (GO:0009214)3.81787919
67* adult walking behavior (GO:0007628)3.79741084
68regulation of postsynaptic membrane potential (GO:0060078)3.77725838
69regulation of voltage-gated calcium channel activity (GO:1901385)3.76798215
70positive regulation of synapse assembly (GO:0051965)3.75442726
71regulation of protein kinase A signaling (GO:0010738)3.72747250
72detection of calcium ion (GO:0005513)3.71752364
73female mating behavior (GO:0060180)3.67778130
74positive regulation of dendritic spine morphogenesis (GO:0061003)3.65331522
75G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.64857855
76cGMP metabolic process (GO:0046068)3.62522452
77neuromuscular process controlling balance (GO:0050885)3.61785397
78positive regulation of neurotransmitter secretion (GO:0001956)3.59731232
79negative regulation of amino acid transport (GO:0051956)3.56714654
80layer formation in cerebral cortex (GO:0021819)3.56675438
81* regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.54225930
82* regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.54225930
83gamma-aminobutyric acid signaling pathway (GO:0007214)3.51276106
84cellular sodium ion homeostasis (GO:0006883)3.50537109
85neuronal action potential propagation (GO:0019227)3.49034343
86neuron cell-cell adhesion (GO:0007158)3.48175559
87proline transport (GO:0015824)3.44916228
88membrane depolarization during action potential (GO:0086010)3.44758253
89lens fiber cell development (GO:0070307)3.44694989
90dendritic spine morphogenesis (GO:0060997)3.44302716
91glutamate secretion (GO:0014047)3.41898895
92regulation of synaptic transmission, GABAergic (GO:0032228)3.41333053
93L-amino acid import (GO:0043092)3.40417044
94primary amino compound metabolic process (GO:1901160)3.40022646
95cAMP metabolic process (GO:0046058)3.39146352
96* regulation of synaptic plasticity (GO:0048167)3.38548354
97* long-term synaptic potentiation (GO:0060291)3.38081820
98mechanosensory behavior (GO:0007638)3.34958301
99negative regulation of dendrite morphogenesis (GO:0050774)3.34566205
100negative regulation of dendrite development (GO:2000171)3.34071094
101* visual learning (GO:0008542)3.34054700
102exploration behavior (GO:0035640)3.32033838
103drinking behavior (GO:0042756)3.31295263
104membrane depolarization (GO:0051899)3.30991310
105* behavioral fear response (GO:0001662)3.29893238
106* behavioral defense response (GO:0002209)3.29893238
107regulation of neurotransmitter secretion (GO:0046928)3.28427507
108* learning (GO:0007612)3.27476562
109* regulation of neurotransmitter uptake (GO:0051580)3.27442835
110regulation of neurotransmitter levels (GO:0001505)3.27432719
111* regulation of neurotransmitter transport (GO:0051588)3.26939523
112cell communication by electrical coupling (GO:0010644)3.24772988
113neurotransmitter transport (GO:0006836)3.23759509
114neuronal ion channel clustering (GO:0045161)3.23363081
115synaptic vesicle endocytosis (GO:0048488)3.23338597
116central nervous system myelination (GO:0022010)3.20976637
117axon ensheathment in central nervous system (GO:0032291)3.20976637
118retinal cone cell development (GO:0046549)3.20903421
119asymmetric protein localization (GO:0008105)3.20530376
120negative regulation of synaptic transmission, GABAergic (GO:0032229)3.18485217
121* visual behavior (GO:0007632)3.17576454
122regulation of synapse maturation (GO:0090128)3.17491541
123regulation of dendritic spine development (GO:0060998)3.16784114
124potassium ion homeostasis (GO:0055075)3.16456780
125* positive regulation of synaptic transmission (GO:0050806)3.15382689
126gamma-aminobutyric acid transport (GO:0015812)3.14570910
127regulation of synapse assembly (GO:0051963)3.13728932
128positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.11956644
129positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.10876305
130postsynaptic membrane organization (GO:0001941)3.08787981
131innervation (GO:0060384)3.06651216
132* multicellular organismal signaling (GO:0035637)3.01542829
133relaxation of smooth muscle (GO:0044557)3.01356364
134regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.00910577
135regulation of vesicle fusion (GO:0031338)3.00540519
136positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.96920630
137cell communication involved in cardiac conduction (GO:0086065)2.95623346
138neuromuscular process (GO:0050905)2.90366336
139ephrin receptor signaling pathway (GO:0048013)2.88752056
140startle response (GO:0001964)2.88424355
141* synaptic transmission (GO:0007268)2.88286707
142regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.87346413
143cell morphogenesis involved in neuron differentiation (GO:0048667)2.87333785
144* adult locomotory behavior (GO:0008344)2.84383791
145positive regulation of potassium ion transmembrane transport (GO:1901381)2.82215696
146amino acid import (GO:0043090)2.79560722
147cardiac muscle adaptation (GO:0014887)2.79398243
148cardiac muscle hypertrophy in response to stress (GO:0014898)2.79398243
149muscle hypertrophy in response to stress (GO:0003299)2.79398243

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.21090261
2GBX2_23144817_ChIP-Seq_PC3_Human3.92418577
3RARB_27405468_Chip-Seq_BRAIN_Mouse3.58032458
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.20212441
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.12494995
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.97588459
7JARID2_20075857_ChIP-Seq_MESCs_Mouse2.72280033
8REST_21632747_ChIP-Seq_MESCs_Mouse2.70579393
9DROSHA_22980978_ChIP-Seq_HELA_Human2.69322442
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.64035189
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.64035189
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.60589005
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.55484011
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.54436518
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.49555389
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.47812350
17AR_21572438_ChIP-Seq_LNCaP_Human2.36639173
18SUZ12_27294783_Chip-Seq_ESCs_Mouse2.33791340
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.33566748
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.28185565
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.28080452
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.26494960
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.19636302
24REST_18959480_ChIP-ChIP_MESCs_Mouse2.18903768
25IKZF1_21737484_ChIP-ChIP_HCT116_Human2.12279388
26MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.07554039
27TAF15_26573619_Chip-Seq_HEK293_Human2.04223448
28EED_16625203_ChIP-ChIP_MESCs_Mouse2.03708570
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.99459643
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.91169444
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.86085793
32RBPJ_22232070_ChIP-Seq_NCS_Mouse1.81611470
33* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.77726698
34CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.70871517
35PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.70413526
36SMAD4_21799915_ChIP-Seq_A2780_Human1.67363185
37ERG_21242973_ChIP-ChIP_JURKAT_Human1.55860005
38P53_22127205_ChIP-Seq_FIBROBLAST_Human1.54222000
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54204514
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52573884
41ZFP57_27257070_Chip-Seq_ESCs_Mouse1.50435642
42* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.50250686
43SMAD3_21741376_ChIP-Seq_EPCs_Human1.48274336
44SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46040810
45NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.44288421
46VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.42525681
47EP300_21415370_ChIP-Seq_HL-1_Mouse1.38543024
48CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38386262
49P300_19829295_ChIP-Seq_ESCs_Human1.38128551
50THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.31803069
51* SOX2_21211035_ChIP-Seq_LN229_Gbm1.30589667
52STAT3_23295773_ChIP-Seq_U87_Human1.29899645
53TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27450803
54BMI1_23680149_ChIP-Seq_NPCS_Mouse1.26063543
55AR_19668381_ChIP-Seq_PC3_Human1.24116368
56RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.21639784
57WT1_25993318_ChIP-Seq_PODOCYTE_Human1.20890877
58SMAD_19615063_ChIP-ChIP_OVARY_Human1.19795624
59RING1B_27294783_Chip-Seq_ESCs_Mouse1.19712848
60AR_25329375_ChIP-Seq_VCAP_Human1.19118509
61CBX2_27304074_Chip-Seq_ESCs_Mouse1.18593556
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.16785600
63PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.16567551
64DNAJC2_21179169_ChIP-ChIP_NT2_Human1.16555720
65TCF4_23295773_ChIP-Seq_U87_Human1.16055074
66ESR1_20079471_ChIP-ChIP_T-47D_Human1.13694733
67SMAD3_21741376_ChIP-Seq_HESCs_Human1.13329001
68CTNNB1_20460455_ChIP-Seq_HCT116_Human1.13277717
69RING1B_27294783_Chip-Seq_NPCs_Mouse1.12629643
70* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11698606
71CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.09204459
72* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09136340
73NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09009234
74SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08087920
75TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07604645
76LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05875161
77MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05139498
78RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.04976606
79RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04854400
80RNF2_27304074_Chip-Seq_NSC_Mouse1.03227123
81YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02723513
82RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02188160
83OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01448955
84* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01293506
85UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01047114
86POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99955652
87TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99955652
88GATA1_26923725_Chip-Seq_HPCs_Mouse0.99725474
89SMAD4_21741376_ChIP-Seq_HESCs_Human0.99301713
90RXR_22108803_ChIP-Seq_LS180_Human0.99254005
91SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.98934915
92VDR_22108803_ChIP-Seq_LS180_Human0.98090930
93TP53_16413492_ChIP-PET_HCT116_Human0.98027136
94AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97753622
95* RUNX2_22187159_ChIP-Seq_PCA_Human0.97722532
96TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.96818963
97CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.95991789
98* AHR_22903824_ChIP-Seq_MCF-7_Human0.95328839
99GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95074846
100EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.95062052
101PRDM14_20953172_ChIP-Seq_ESCs_Human0.94944766
102TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.94680935
103CTCF_27219007_Chip-Seq_Bcells_Human0.94394398
104NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93967162
105ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93637997
106POU3F2_20337985_ChIP-ChIP_501MEL_Human0.93563144
107FUS_26573619_Chip-Seq_HEK293_Human0.93439026
108KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.92667473
109CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.92494965
110HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.91884857
111SMAD3_21741376_ChIP-Seq_ESCs_Human0.91495119
112TP53_18474530_ChIP-ChIP_U2OS_Human0.91374107
113* ARNT_22903824_ChIP-Seq_MCF-7_Human0.91153459
114KDM2B_26808549_Chip-Seq_K562_Human0.91131414
115FLI1_21867929_ChIP-Seq_TH2_Mouse0.91101647
116ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.90625689
117TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90065755
118BCAT_22108803_ChIP-Seq_LS180_Human0.89927440
119CDX2_19796622_ChIP-Seq_MESCs_Mouse0.89103803
120BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.87489746
121WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.87390614
122* SMAD4_21741376_ChIP-Seq_EPCs_Human0.87058999

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy8.94548500
2MP0004859_abnormal_synaptic_plasticity5.36616647
3MP0003880_abnormal_central_pattern4.16904518
4MP0003635_abnormal_synaptic_transmissio3.91088135
5MP0009745_abnormal_behavioral_response3.61551473
6MP0002063_abnormal_learning/memory/cond3.37834117
7MP0001529_abnormal_vocalization3.05658593
8MP0002064_seizures2.92562188
9MP0009046_muscle_twitch2.90432290
10MP0001486_abnormal_startle_reflex2.82626872
11MP0004270_analgesia2.78032890
12MP0002572_abnormal_emotion/affect_behav2.71954862
13MP0002272_abnormal_nervous_system2.53099420
14MP0001968_abnormal_touch/_nociception2.42751357
15MP0001984_abnormal_olfaction2.34432631
16MP0005423_abnormal_somatic_nervous2.17673001
17MP0002909_abnormal_adrenal_gland2.14906951
18MP0005551_abnormal_eye_electrophysiolog2.12733285
19MP0000566_synostosis2.08315470
20MP0001188_hyperpigmentation2.03171495
21MP0005646_abnormal_pituitary_gland2.01831132
22MP0005386_behavior/neurological_phenoty1.96574949
23MP0004924_abnormal_behavior1.96574949
24MP0001501_abnormal_sleep_pattern1.93848466
25MP0002734_abnormal_mechanical_nocicepti1.93445431
26MP0002090_abnormal_vision1.79347286
27MP0002067_abnormal_sensory_capabilities1.73931289
28MP0008569_lethality_at_weaning1.71269547
29MP0002557_abnormal_social/conspecific_i1.65331282
30MP0001970_abnormal_pain_threshold1.60138961
31MP0005409_darkened_coat_color1.57696393
32MP0003879_abnormal_hair_cell1.55296235
33MP0002736_abnormal_nociception_after1.53108223
34MP0003136_yellow_coat_color1.51997706
35MP0004811_abnormal_neuron_physiology1.50374482
36MP0001440_abnormal_grooming_behavior1.50067376
37MP0001502_abnormal_circadian_rhythm1.46737576
38MP0002184_abnormal_innervation1.46152984
39MP0002733_abnormal_thermal_nociception1.42181753
40MP0003938_abnormal_ear_development1.28897074
41MP0008872_abnormal_physiological_respon1.28853705
42MP0002066_abnormal_motor_capabilities/c1.23341630
43MP0001905_abnormal_dopamine_level1.22844908
44MP0002882_abnormal_neuron_morphology1.22670531
45MP0002735_abnormal_chemical_nociception1.21593346
46MP0005394_taste/olfaction_phenotype1.21133198
47MP0005499_abnormal_olfactory_system1.21133198
48MP0001346_abnormal_lacrimal_gland1.21007361
49MP0006072_abnormal_retinal_apoptosis1.17355173
50MP0004885_abnormal_endolymph1.16900241
51MP0000955_abnormal_spinal_cord1.16839173
52MP0003633_abnormal_nervous_system1.14710476
53MP0008874_decreased_physiological_sensi1.14243903
54MP0001177_atelectasis1.13950871
55MP0004233_abnormal_muscle_weight1.12562393
56MP0003075_altered_response_to1.10046329
57MP0000026_abnormal_inner_ear1.09103363
58MP0000778_abnormal_nervous_system1.08381191
59MP0009780_abnormal_chondrocyte_physiolo1.08089927
60MP0003122_maternal_imprinting1.06406455
61MP0002229_neurodegeneration1.05874573
62MP0000013_abnormal_adipose_tissue1.05548659
63MP0003329_amyloid_beta_deposits1.04023756
64MP0004085_abnormal_heartbeat1.00800542
65MP0009379_abnormal_foot_pigmentation0.98322432
66MP0008961_abnormal_basal_metabolism0.98288839
67MP0010386_abnormal_urinary_bladder0.97382473
68MP0002069_abnormal_eating/drinking_beha0.96905446
69MP0000631_abnormal_neuroendocrine_gland0.91858839
70MP0005167_abnormal_blood-brain_barrier0.91693760
71MP0006292_abnormal_olfactory_placode0.90639669
72MP0004142_abnormal_muscle_tone0.90451766
73MP0002653_abnormal_ependyma_morphology0.90140261
74MP0003632_abnormal_nervous_system0.88695608
75MP0003787_abnormal_imprinting0.87541280
76MP0002152_abnormal_brain_morphology0.85872870
77MP0003011_delayed_dark_adaptation0.85672968
78MP0003631_nervous_system_phenotype0.84853126
79MP0005253_abnormal_eye_physiology0.84442054
80MP0005248_abnormal_Harderian_gland0.81162922
81MP0004043_abnormal_pH_regulation0.80323212
82MP0005535_abnormal_body_temperature0.78647180
83MP0004742_abnormal_vestibular_system0.78090103
84MP0000579_abnormal_nail_morphology0.77629567
85MP0003137_abnormal_impulse_conducting0.76795369
86MP0002837_dystrophic_cardiac_calcinosis0.76570867
87MP0002752_abnormal_somatic_nervous0.76391906
88MP0004036_abnormal_muscle_relaxation0.75968403
89MP0000751_myopathy0.75917829
90MP0008877_abnormal_DNA_methylation0.73762221
91MP0010234_abnormal_vibrissa_follicle0.71447668
92MP0002928_abnormal_bile_duct0.70760633
93MP0004215_abnormal_myocardial_fiber0.68927784
94MP0003861_abnormal_nervous_system0.68709375
95MP0005195_abnormal_posterior_eye0.67861135
96MP0006276_abnormal_autonomic_nervous0.66117998
97MP0002638_abnormal_pupillary_reflex0.65828800
98MP0000537_abnormal_urethra_morphology0.65758189
99MP0000462_abnormal_digestive_system0.64976747
100MP0004858_abnormal_nervous_system0.64670131
101MP0005645_abnormal_hypothalamus_physiol0.64162443
102MP0004510_myositis0.63885632
103MP0000569_abnormal_digit_pigmentation0.63832405
104MP0000920_abnormal_myelination0.62336191
105MP0005623_abnormal_meninges_morphology0.61850204
106MP0003634_abnormal_glial_cell0.61828658
107MP0003690_abnormal_glial_cell0.61014694
108MP0010030_abnormal_orbit_morphology0.60348091
109MP0004084_abnormal_cardiac_muscle0.59926752
110MP0000534_abnormal_ureter_morphology0.58112169
111MP0009250_abnormal_appendicular_skeleto0.57159213
112MP0005595_abnormal_vascular_smooth0.56931733
113MP0000383_abnormal_hair_follicle0.56573637
114MP0001664_abnormal_digestion0.55896232
115MP0004147_increased_porphyrin_level0.54818316
116MP0002089_abnormal_postnatal_growth/wei0.54045435
117MP0010770_preweaning_lethality0.53795972
118MP0002082_postnatal_lethality0.53795972
119MP0001963_abnormal_hearing_physiology0.52308767
120MP0005620_abnormal_muscle_contractility0.51043722
121MP0008789_abnormal_olfactory_epithelium0.50697232
122MP0003283_abnormal_digestive_organ0.50669221
123MP0004145_abnormal_muscle_electrophysio0.48631702
124MP0002332_abnormal_exercise_endurance0.48144396
125MP0001485_abnormal_pinna_reflex0.47008730
126MP0000230_abnormal_systemic_arterial0.46416802
127MP0002234_abnormal_pharynx_morphology0.45357657

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)8.19868168
2Focal motor seizures (HP:0011153)7.51737800
3Congenital stationary night blindness (HP:0007642)5.76609061
4Focal seizures (HP:0007359)5.33979892
5Split foot (HP:0001839)4.89530951
6Oligodactyly (hands) (HP:0001180)4.79149557
7Epileptic encephalopathy (HP:0200134)4.61068083
8Synostosis involving the elbow (HP:0003938)4.43387362
9Humeroradial synostosis (HP:0003041)4.43387362
10Annular pancreas (HP:0001734)4.39302856
11Febrile seizures (HP:0002373)4.36516114
12Central scotoma (HP:0000603)4.16208883
13Torticollis (HP:0000473)4.15715388
14Absence seizures (HP:0002121)4.08446333
15Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.94293770
16Dysdiadochokinesis (HP:0002075)3.89347551
17Visual hallucinations (HP:0002367)3.88326052
18Dialeptic seizures (HP:0011146)3.77253258
19Hypoplastic pelvis (HP:0008839)3.72134032
20Generalized tonic-clonic seizures (HP:0002069)3.69743512
21Resting tremor (HP:0002322)3.69344132
22Severe visual impairment (HP:0001141)3.68534708
23Dysmetric saccades (HP:0000641)3.65481667
24Gaze-evoked nystagmus (HP:0000640)3.63332361
25Anxiety (HP:0000739)3.54814421
26Focal dystonia (HP:0004373)3.53933483
27Prolonged QT interval (HP:0001657)3.53010982
28Action tremor (HP:0002345)3.49625216
29Craniofacial dystonia (HP:0012179)3.49114604
30Poor eye contact (HP:0000817)3.47778559
31Depression (HP:0000716)3.47748311
32Broad-based gait (HP:0002136)3.45573372
33Ankle clonus (HP:0011448)3.44685942
34Progressive cerebellar ataxia (HP:0002073)3.44482780
35Abnormality of macular pigmentation (HP:0008002)3.43609894
36Oligodactyly (HP:0012165)3.40358987
37Abnormal social behavior (HP:0012433)3.24161777
38Impaired social interactions (HP:0000735)3.24161777
39Scanning speech (HP:0002168)3.22961724
40Fibular aplasia (HP:0002990)3.21576253
41Impaired vibration sensation in the lower limbs (HP:0002166)3.21455407
42Abnormal ciliary motility (HP:0012262)3.13889945
43Dynein arm defect of respiratory motile cilia (HP:0012255)3.11517298
44Absent/shortened dynein arms (HP:0200106)3.11517298
45Abnormality of binocular vision (HP:0011514)3.10849341
46Diplopia (HP:0000651)3.10849341
47Atonic seizures (HP:0010819)3.09557497
48Truncal ataxia (HP:0002078)3.04671690
49Stereotypic behavior (HP:0000733)3.01210133
50Degeneration of the lateral corticospinal tracts (HP:0002314)2.99814408
51Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.99814408
52Urinary bladder sphincter dysfunction (HP:0002839)2.99352749
53Dysmetria (HP:0001310)2.92869830
54Abnormal respiratory epithelium morphology (HP:0012253)2.90835041
55Abnormal respiratory motile cilium morphology (HP:0005938)2.90835041
56Abnormality of the corticospinal tract (HP:0002492)2.88982877
57Hyperventilation (HP:0002883)2.83401802
58Abnormal EKG (HP:0003115)2.81924113
59Ankyloglossia (HP:0010296)2.81446094
60Abnormal eating behavior (HP:0100738)2.79633571
61Postural instability (HP:0002172)2.74898394
62Radial bowing (HP:0002986)2.73320953
63Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.68859753
64Pointed chin (HP:0000307)2.68757141
65Mutism (HP:0002300)2.68457038
66Scotoma (HP:0000575)2.67774748
67Symphalangism affecting the phalanges of the hand (HP:0009773)2.64007542
68Bowing of the arm (HP:0006488)2.60979771
69Bowed forearm bones (HP:0003956)2.60979771
70Abnormal respiratory motile cilium physiology (HP:0012261)2.60120247
71Impaired smooth pursuit (HP:0007772)2.55797626
72Urinary urgency (HP:0000012)2.48252109
73Epileptiform EEG discharges (HP:0011182)2.47168085
74EEG with generalized epileptiform discharges (HP:0011198)2.45292185
75Sleep apnea (HP:0010535)2.42287085
76Lower limb amyotrophy (HP:0007210)2.42058770
77Impaired vibratory sensation (HP:0002495)2.40932810
78Broad ribs (HP:0000885)2.40734410
79Spastic gait (HP:0002064)2.38224578
80Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.38181796
81Hemiparesis (HP:0001269)2.37467533
82Incomplete penetrance (HP:0003829)2.31656172
83Ventricular fibrillation (HP:0001663)2.30992021
84Bradykinesia (HP:0002067)2.30561585
85Abnormal rod and cone electroretinograms (HP:0008323)2.29315135
86Neurofibrillary tangles (HP:0002185)2.27078738
87Amblyopia (HP:0000646)2.26465670
88Abnormality of ocular smooth pursuit (HP:0000617)2.26410223
89Limb dystonia (HP:0002451)2.23391488
90Adactyly (HP:0009776)2.21788644
91Gait imbalance (HP:0002141)2.21360090
92Drooling (HP:0002307)2.19204831
93Excessive salivation (HP:0003781)2.19204831
94Supranuclear gaze palsy (HP:0000605)2.17280517
95Decreased central vision (HP:0007663)2.16335240
96Intention tremor (HP:0002080)2.16271857
97Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.15455655
98Genetic anticipation (HP:0003743)2.14394302
99Abnormality of the pubic bones (HP:0003172)2.13452096
100Abnormal finger flexion creases (HP:0006143)2.13219770
101Hypoplastic nipples (HP:0002557)2.12149344
102Rhinitis (HP:0012384)2.12070160
103Status epilepticus (HP:0002133)2.09310819
104Hypsarrhythmia (HP:0002521)2.07553043
105Progressive inability to walk (HP:0002505)2.07004354
106Aplasia/hypoplasia of the uterus (HP:0008684)2.03720728
107Congenital primary aphakia (HP:0007707)2.03134947
108Sudden death (HP:0001699)2.01607531
109Atrial fibrillation (HP:0005110)2.01543293
110Syncope (HP:0001279)2.00128709
111Clonus (HP:0002169)1.98971738
112Distal lower limb amyotrophy (HP:0008944)1.96990131
113Primary atrial arrhythmia (HP:0001692)1.96313010
114Abnormality of oral frenula (HP:0000190)1.96073510
115Abnormality of the lower motor neuron (HP:0002366)1.94361502
116Abnormality of saccadic eye movements (HP:0000570)1.94003788
117Fetal akinesia sequence (HP:0001989)1.93133970
118Megalencephaly (HP:0001355)1.92747103
119Bundle branch block (HP:0011710)1.90586550
120Papilledema (HP:0001085)1.90482996
121Tetraplegia (HP:0002445)1.87707193
122Absent speech (HP:0001344)1.87599995
123Septo-optic dysplasia (HP:0100842)1.87430229
124Morphological abnormality of the pyramidal tract (HP:0002062)1.86758694
125Lower limb muscle weakness (HP:0007340)1.86569541
126Hemiplegia (HP:0002301)1.86069630
127Neuronal loss in central nervous system (HP:0002529)1.84776143
128Dysphonia (HP:0001618)1.84058793
129Inability to walk (HP:0002540)1.83191707
130Medial flaring of the eyebrow (HP:0010747)1.82929902
131Supraventricular tachycardia (HP:0004755)1.82758204
132Cerebral inclusion bodies (HP:0100314)1.81862105
133Exercise-induced myalgia (HP:0003738)1.81395339
134Type II lissencephaly (HP:0007260)1.79730019
135Nephrogenic diabetes insipidus (HP:0009806)1.79434193
136Spinal canal stenosis (HP:0003416)1.78907701
137Lower limb asymmetry (HP:0100559)1.77729478
138Polygenic inheritance (HP:0010982)1.75097518
139Gait ataxia (HP:0002066)1.74916694
140Atrioventricular block (HP:0001678)1.74871954
141Supraventricular arrhythmia (HP:0005115)1.74392571
142Deeply set eye (HP:0000490)1.74303108
143Generalized myoclonic seizures (HP:0002123)1.73963530
144Barrel-shaped chest (HP:0001552)1.68820401

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA47.27876022
2NTRK33.76222812
3MAP3K93.36326624
4MAP3K42.75702265
5RIPK42.51275612
6MINK12.43967514
7KSR22.42058407
8CAMKK12.37586574
9DAPK22.35052162
10KSR12.27864878
11CAMKK22.15016736
12MAP3K132.03963739
13FES2.03901501
14SIK32.02700716
15ARAF2.00630407
16PAK61.98777655
17PRKD31.84581176
18MARK11.79204457
19TNIK1.71495649
20FGFR21.71027469
21MAP2K71.65708859
22NTRK21.61299741
23PRPF4B1.57380710
24CASK1.57302565
25TAOK11.56523791
26NTRK11.55484939
27LATS21.54774854
28CDK51.50833158
29SIK21.41983620
30SGK2231.41392265
31SGK4941.41392265
32PNCK1.33264895
33MAPK151.32147896
34NEK11.30228151
35SGK21.28195512
36DAPK11.18070261
37BMPR21.17046552
38RAF11.14947882
39STK381.14235142
40MAP3K21.13445951
41PINK11.12206800
42PAK31.11073588
43MAP2K41.03181620
44SGK31.02982538
45PKN10.99631289
46BMPR1B0.96532989
47PRKCG0.91377993
48CAMK10.89913904
49CDK180.89756697
50SGK10.88018707
51CAMK2A0.87232296
52TNK20.83597889
53CDK140.81149301
54PRKCH0.78831065
55CDK150.78751841
56TYRO30.76543506
57STK110.74538699
58DYRK1A0.73128598
59MARK20.72190873
60PLK20.71659809
61BCR0.71299204
62BRAF0.70818887
63GRK50.70536630
64STK160.70174633
65MAPK130.70027650
66WNK10.68472584
67CDK11A0.67875465
68AKT30.67597828
69NEK60.67571718
70MAPK120.66227352
71PIK3CA0.66154428
72CAMK2B0.65732589
73TRIB30.64065762
74PHKG20.63852969
75PHKG10.63852969
76MAP3K10.62916201
77MAP2K10.61247526
78PDPK10.59925348
79SCYL20.59693495
80CAMK40.59307962
81STK38L0.58657514
82RIPK10.58203124
83RPS6KA30.57465512
84PDK10.57331780
85LATS10.57225319
86PRKCZ0.56005625
87CAMK2D0.54802752
88PTK2B0.51967510
89NME10.51670886
90PRKCE0.49801855
91ERBB20.49735390
92RET0.49548778
93UHMK10.49069850
94MOS0.48833382
95MAPK100.48043597
96IRAK20.47977940
97FYN0.47726426
98OBSCN0.47096267
99PRKG10.46469198
100FER0.44814345
101PRKCQ0.44572626
102RPS6KB10.44501699
103TESK10.43782948
104LIMK10.42835437
105PRKACA0.42346066
106PRKD20.41499216
107WNK40.40767897
108* PRKCB0.40619968
109TAOK20.40198370
110PRKCI0.39359469
111ROCK10.38851144
112MET0.38818313
113MAP3K120.37312901
114ADRBK20.37295630
115TSSK60.37249715
116STK390.36603534
117CDK190.36283270
118WNK30.34504677
119MUSK0.34470501
120CSNK1G20.34221627
121PRKACG0.33669462
122PRKCA0.33531644
123MAP3K70.33254414
124DAPK30.32718690
125CSNK1A10.30733608
126CAMK2G0.30331405
127MAPK80.29628484
128CDK30.28206994
129OXSR10.26525591

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047403.73614025
2Nicotine addiction_Homo sapiens_hsa050333.51610150
3GABAergic synapse_Homo sapiens_hsa047273.26137017
4* Morphine addiction_Homo sapiens_hsa050323.17975812
5Synaptic vesicle cycle_Homo sapiens_hsa047213.15979812
6Circadian entrainment_Homo sapiens_hsa047132.90472618
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.83071580
8Glutamatergic synapse_Homo sapiens_hsa047242.47317887
9Long-term potentiation_Homo sapiens_hsa047202.36870913
10* Amphetamine addiction_Homo sapiens_hsa050312.34282082
11Renin secretion_Homo sapiens_hsa049242.30902821
12* Dopaminergic synapse_Homo sapiens_hsa047282.29709920
13Cholinergic synapse_Homo sapiens_hsa047252.25457303
14Salivary secretion_Homo sapiens_hsa049702.20727753
15* Cocaine addiction_Homo sapiens_hsa050302.10080920
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.94021161
17Phototransduction_Homo sapiens_hsa047441.91295039
18Insulin secretion_Homo sapiens_hsa049111.91253546
19Oxytocin signaling pathway_Homo sapiens_hsa049211.85680927
20Serotonergic synapse_Homo sapiens_hsa047261.83964180
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.69539181
22* Calcium signaling pathway_Homo sapiens_hsa040201.67276511
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.66717397
24Gastric acid secretion_Homo sapiens_hsa049711.58331689
25Taste transduction_Homo sapiens_hsa047421.57059033
26Long-term depression_Homo sapiens_hsa047301.50573715
27* Gap junction_Homo sapiens_hsa045401.35551311
28* cAMP signaling pathway_Homo sapiens_hsa040241.34559219
29GnRH signaling pathway_Homo sapiens_hsa049121.33965926
30Collecting duct acid secretion_Homo sapiens_hsa049661.29842482
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.21620372
32cGMP-PKG signaling pathway_Homo sapiens_hsa040221.19168366
33* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.17438234
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.16512147
35Vascular smooth muscle contraction_Homo sapiens_hsa042701.14803986
36Phosphatidylinositol signaling system_Homo sapiens_hsa040701.14772780
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.03459324
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.99616417
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.97348436
40Cardiac muscle contraction_Homo sapiens_hsa042600.95075746
41Glioma_Homo sapiens_hsa052140.93572696
42Type II diabetes mellitus_Homo sapiens_hsa049300.91673291
43Dilated cardiomyopathy_Homo sapiens_hsa054140.86909239
44Phospholipase D signaling pathway_Homo sapiens_hsa040720.84707106
45Estrogen signaling pathway_Homo sapiens_hsa049150.82065022
46Circadian rhythm_Homo sapiens_hsa047100.81036592
47Hedgehog signaling pathway_Homo sapiens_hsa043400.79780756
48* Alcoholism_Homo sapiens_hsa050340.78986407
49Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.78158322
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77581354
51ErbB signaling pathway_Homo sapiens_hsa040120.77515455
52Nitrogen metabolism_Homo sapiens_hsa009100.76277862
53Melanogenesis_Homo sapiens_hsa049160.75938956
54Alzheimers disease_Homo sapiens_hsa050100.74546111
55Oocyte meiosis_Homo sapiens_hsa041140.74489953
56Pancreatic secretion_Homo sapiens_hsa049720.73843048
57Non-small cell lung cancer_Homo sapiens_hsa052230.73312743
58Hippo signaling pathway_Homo sapiens_hsa043900.73205140
59Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68854218
60Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.68066453
61Axon guidance_Homo sapiens_hsa043600.67910001
62MAPK signaling pathway_Homo sapiens_hsa040100.65144229
63Rap1 signaling pathway_Homo sapiens_hsa040150.64134600
64Vibrio cholerae infection_Homo sapiens_hsa051100.64021971
65Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63198558
66Type I diabetes mellitus_Homo sapiens_hsa049400.63195536
67Basal cell carcinoma_Homo sapiens_hsa052170.62780026
68Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.62745690
69Choline metabolism in cancer_Homo sapiens_hsa052310.61039810
70Wnt signaling pathway_Homo sapiens_hsa043100.60330830
71Thyroid hormone synthesis_Homo sapiens_hsa049180.58576691
72Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51807728
73Ras signaling pathway_Homo sapiens_hsa040140.51558475
74Tight junction_Homo sapiens_hsa045300.51280855
75Inositol phosphate metabolism_Homo sapiens_hsa005620.50740189
76Chemokine signaling pathway_Homo sapiens_hsa040620.50412332
77Glucagon signaling pathway_Homo sapiens_hsa049220.50111165
78Dorso-ventral axis formation_Homo sapiens_hsa043200.49927941
79Vitamin B6 metabolism_Homo sapiens_hsa007500.49604785
80Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49195499
81mTOR signaling pathway_Homo sapiens_hsa041500.48389117
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46130941
83Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.46018277
84Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.45380476
85Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44304610
86Neurotrophin signaling pathway_Homo sapiens_hsa047220.42033011
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.41540858
88Bile secretion_Homo sapiens_hsa049760.40693859
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.40550359
90Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39949199
91VEGF signaling pathway_Homo sapiens_hsa043700.39191371
92African trypanosomiasis_Homo sapiens_hsa051430.36937028
93Histidine metabolism_Homo sapiens_hsa003400.35411857
94Endometrial cancer_Homo sapiens_hsa052130.33709673
95Renal cell carcinoma_Homo sapiens_hsa052110.33699733
96Ovarian steroidogenesis_Homo sapiens_hsa049130.31651679
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30724167
98Endocytosis_Homo sapiens_hsa041440.30485686
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.29182970
100Fructose and mannose metabolism_Homo sapiens_hsa000510.29130644
101Huntingtons disease_Homo sapiens_hsa050160.28544643
102Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.28374220
103Platelet activation_Homo sapiens_hsa046110.27848219
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.27748180
105Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.25934253
106Ether lipid metabolism_Homo sapiens_hsa005650.25841030
107Mineral absorption_Homo sapiens_hsa049780.25701857
108Prion diseases_Homo sapiens_hsa050200.25151199
109Insulin signaling pathway_Homo sapiens_hsa049100.24903999
110Butanoate metabolism_Homo sapiens_hsa006500.24223131
111Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.20273726
112Regulation of autophagy_Homo sapiens_hsa041400.19757421
113Protein digestion and absorption_Homo sapiens_hsa049740.18904723
114Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.18822467
115TGF-beta signaling pathway_Homo sapiens_hsa043500.18564306
116Parkinsons disease_Homo sapiens_hsa050120.18332648
117Oxidative phosphorylation_Homo sapiens_hsa001900.16683367
118AMPK signaling pathway_Homo sapiens_hsa041520.15968083
119Renin-angiotensin system_Homo sapiens_hsa046140.14436624
120Maturity onset diabetes of the young_Homo sapiens_hsa049500.14149970
121Linoleic acid metabolism_Homo sapiens_hsa005910.13753390

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