DRD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)6.79795122
2pyrimidine nucleobase catabolic process (GO:0006208)5.99805041
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.74620796
4* synaptic transmission, dopaminergic (GO:0001963)5.70862520
5regulation of short-term neuronal synaptic plasticity (GO:0048172)5.67870518
6synaptic vesicle maturation (GO:0016188)5.59552234
7* prepulse inhibition (GO:0060134)5.50488289
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.47547222
9locomotory exploration behavior (GO:0035641)5.36481807
10adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)5.24092564
11synaptic vesicle exocytosis (GO:0016079)5.18479367
12vocalization behavior (GO:0071625)5.13092382
13membrane depolarization during cardiac muscle cell action potential (GO:0086012)5.07863517
14neurofilament cytoskeleton organization (GO:0060052)5.05447986
15presynaptic membrane organization (GO:0097090)5.03917756
16cell migration in hindbrain (GO:0021535)4.98035614
17adenosine receptor signaling pathway (GO:0001973)4.98019053
18* regulation of synapse structural plasticity (GO:0051823)4.78054165
19neuromuscular synaptic transmission (GO:0007274)4.77472455
20* response to amphetamine (GO:0001975)4.77363618
21regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.75145925
22regulation of glutamate receptor signaling pathway (GO:1900449)4.54423133
23neurotransmitter secretion (GO:0007269)4.54243578
24mating behavior (GO:0007617)4.53437404
25nucleobase catabolic process (GO:0046113)4.52210061
26axonal fasciculation (GO:0007413)4.49074237
27neuron recognition (GO:0008038)4.48388741
28positive regulation of synaptic transmission, GABAergic (GO:0032230)4.45614298
29positive regulation of synaptic transmission, glutamatergic (GO:0051968)4.45191221
30* regulation of long-term neuronal synaptic plasticity (GO:0048169)4.43181449
31regulation of synaptic vesicle exocytosis (GO:2000300)4.40470374
32neurotransmitter-gated ion channel clustering (GO:0072578)4.38300851
33regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.31618237
34* regulation of neuronal synaptic plasticity (GO:0048168)4.31312682
35cAMP catabolic process (GO:0006198)4.28312668
36synaptic vesicle docking involved in exocytosis (GO:0016081)4.26858339
37regulation of dendritic spine morphogenesis (GO:0061001)4.22104003
38* dopamine receptor signaling pathway (GO:0007212)4.21689622
39glutamate secretion (GO:0014047)4.20352997
40regulation of dopamine metabolic process (GO:0042053)4.10930823
41regulation of catecholamine metabolic process (GO:0042069)4.10930823
42ganglion development (GO:0061548)4.09781932
43neuromuscular process controlling balance (GO:0050885)4.09677982
44* striatum development (GO:0021756)4.09057732
45mitochondrion transport along microtubule (GO:0047497)4.05490994
46establishment of mitochondrion localization, microtubule-mediated (GO:0034643)4.05490994
47dendritic spine morphogenesis (GO:0060997)4.03004625
48peripheral nervous system neuron development (GO:0048935)3.99233722
49positive regulation of neurotransmitter secretion (GO:0001956)3.98529984
50exploration behavior (GO:0035640)3.97457598
51protein localization to synapse (GO:0035418)3.97054458
52presynaptic membrane assembly (GO:0097105)3.96970988
53ionotropic glutamate receptor signaling pathway (GO:0035235)3.96395316
54regulation of protein kinase A signaling (GO:0010738)3.93654862
55transmission of nerve impulse (GO:0019226)3.92482127
56regulation of synaptic vesicle transport (GO:1902803)3.91521271
57establishment of mitochondrion localization (GO:0051654)3.91505340
58regulation of excitatory postsynaptic membrane potential (GO:0060079)3.91232611
59* neuron-neuron synaptic transmission (GO:0007270)3.90884323
60regulation of glutamate secretion (GO:0014048)3.89225631
61activation of protein kinase A activity (GO:0034199)3.86520058
62layer formation in cerebral cortex (GO:0021819)3.85693235
63neuron cell-cell adhesion (GO:0007158)3.85111289
64membrane hyperpolarization (GO:0060081)3.83653594
65positive regulation of membrane potential (GO:0045838)3.81078829
66G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.79152443
67cyclic nucleotide catabolic process (GO:0009214)3.77073112
68synaptic transmission, cholinergic (GO:0007271)3.75402174
69neuronal ion channel clustering (GO:0045161)3.74969073
70regulation of female receptivity (GO:0045924)3.73813281
71regulation of neurotransmitter levels (GO:0001505)3.73754302
72gamma-aminobutyric acid transport (GO:0015812)3.72093464
73regulation of postsynaptic membrane potential (GO:0060078)3.69831144
74synaptic transmission, glutamatergic (GO:0035249)3.67836024
75neurotransmitter transport (GO:0006836)3.66566745
76neuronal action potential propagation (GO:0019227)3.64043367
77* regulation of synaptic transmission, glutamatergic (GO:0051966)3.63429718
78* positive regulation of neurotransmitter transport (GO:0051590)3.61662374
79dendrite morphogenesis (GO:0048813)3.56712509
80* behavioral response to cocaine (GO:0048148)3.55785021
81neuron maturation (GO:0042551)3.54024136
82cAMP metabolic process (GO:0046058)3.51839721
83glutamate receptor signaling pathway (GO:0007215)3.50361636
84cellular potassium ion homeostasis (GO:0030007)3.49076803
85long-term synaptic potentiation (GO:0060291)3.47408467
86regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.44154723
87sympathetic nervous system development (GO:0048485)3.43834933
88* regulation of synaptic plasticity (GO:0048167)3.42888695
89behavioral defense response (GO:0002209)3.42765667
90behavioral fear response (GO:0001662)3.42765667
91* negative regulation of cytosolic calcium ion concentration (GO:0051481)3.41725374
92membrane depolarization during action potential (GO:0086010)3.38929965
93glycine transport (GO:0015816)3.38749112
94neurotransmitter catabolic process (GO:0042135)3.37586923
95cerebellar granule cell differentiation (GO:0021707)3.35967737
96postsynaptic membrane organization (GO:0001941)3.34661488
97female mating behavior (GO:0060180)3.34334435
98regulation of vesicle fusion (GO:0031338)3.33760960
99* long-term memory (GO:0007616)3.33419037
100* response to amine (GO:0014075)3.32403655
101membrane depolarization (GO:0051899)3.31711228
102negative regulation of dendrite development (GO:2000171)3.31075250
103* visual learning (GO:0008542)3.30019039
104cell differentiation in hindbrain (GO:0021533)3.29414729
105cranial nerve development (GO:0021545)3.29291129
106serotonin metabolic process (GO:0042428)3.29024570
107neuromuscular process controlling posture (GO:0050884)3.26548826
108positive regulation of synapse maturation (GO:0090129)3.26234500
109catecholamine transport (GO:0051937)3.25386060
110retinal ganglion cell axon guidance (GO:0031290)3.25071921
111regulation of dendritic spine development (GO:0060998)3.24911652
112drinking behavior (GO:0042756)3.23902173
113positive regulation of gastrulation (GO:2000543)3.22612965
114left/right pattern formation (GO:0060972)3.22239033
115dopamine transport (GO:0015872)3.22218970
116* regulation of neurotransmitter transport (GO:0051588)3.22111367
117regulation of neurotransmitter secretion (GO:0046928)3.21076111
118* synapse assembly (GO:0007416)3.20618142
119urinary tract smooth muscle contraction (GO:0014848)3.18860097
120cGMP metabolic process (GO:0046068)3.17825186
121cellular response to nicotine (GO:0071316)3.17152780
122negative regulation of neurotransmitter secretion (GO:0046929)3.16572344
123* visual behavior (GO:0007632)3.15751680
124regulation of norepinephrine secretion (GO:0014061)3.15142912
125fear response (GO:0042596)3.14057503
126cAMP biosynthetic process (GO:0006171)3.13835541
127* learning (GO:0007612)3.12925923
128neuron remodeling (GO:0016322)3.12382902
129epithelial cilium movement (GO:0003351)3.08517529
130detection of temperature stimulus (GO:0016048)3.08153837
131neuromuscular process (GO:0050905)3.07927977
132spinal cord association neuron differentiation (GO:0021527)3.07065332
133regulation of membrane repolarization (GO:0060306)3.06595616
134positive regulation of dendritic spine development (GO:0060999)3.06478429
135body morphogenesis (GO:0010171)3.03697594
136negative regulation of microtubule polymerization (GO:0031115)3.02762283
137cerebellar Purkinje cell differentiation (GO:0021702)3.02369666
138positive regulation of synapse assembly (GO:0051965)3.02266172
139phenol-containing compound catabolic process (GO:0019336)3.00680711
140catecholamine biosynthetic process (GO:0042423)3.00327872
141catechol-containing compound biosynthetic process (GO:0009713)3.00327872
142norepinephrine metabolic process (GO:0042415)2.97584275
143protein localization to microtubule (GO:0035372)2.95195558
144cerebral cortex radially oriented cell migration (GO:0021799)2.94890701
145innervation (GO:0060384)2.93453427
146forebrain neuron differentiation (GO:0021879)2.93400344
147axon extension (GO:0048675)2.88469783
148cranial nerve morphogenesis (GO:0021602)2.87912960
149regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.83817191
150central nervous system projection neuron axonogenesis (GO:0021952)2.79287325
151* neuron migration (GO:0001764)2.79184881
152central nervous system myelination (GO:0022010)2.78219681
153axon ensheathment in central nervous system (GO:0032291)2.78219681
154calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.77785138
155* adult walking behavior (GO:0007628)2.77579974
156* synapse organization (GO:0050808)2.77145801
157* substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.76948816
158* substrate-independent telencephalic tangential migration (GO:0021826)2.76948816
159paraxial mesoderm development (GO:0048339)2.75277395
160embryonic body morphogenesis (GO:0010172)2.73410881
161negative regulation of neurotransmitter transport (GO:0051589)2.73378168
162regulation of axonogenesis (GO:0050770)2.72994111
163* response to nicotine (GO:0035094)2.72227570
164membrane repolarization (GO:0086009)2.71676599
165membrane repolarization during action potential (GO:0086011)2.70232799
166regulation of glucocorticoid secretion (GO:2000849)2.68395792
167* positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.68008913
168short-term memory (GO:0007614)2.67421256
169G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.66258220
170negative regulation of axonogenesis (GO:0050771)2.65407861
171axon extension involved in axon guidance (GO:0048846)2.62507122
172neuron projection extension involved in neuron projection guidance (GO:1902284)2.62507122
173cilium movement (GO:0003341)2.61049781
174dopamine biosynthetic process (GO:0042416)2.59283431
175spinal cord development (GO:0021510)2.56468069

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.77545788
2RARB_27405468_Chip-Seq_BRAIN_Mouse3.86451722
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.12993456
4GBX2_23144817_ChIP-Seq_PC3_Human3.12801082
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.12442869
6DROSHA_22980978_ChIP-Seq_HELA_Human2.92474892
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.90721606
8CBX2_27304074_Chip-Seq_ESCs_Mouse2.80531354
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.71956093
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.71956093
11* REST_21632747_ChIP-Seq_MESCs_Mouse2.70766675
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.69637829
13MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.65766022
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.63244531
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.60561128
16* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.55800089
17TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.55693756
18* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.46505148
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.42229622
20IKZF1_21737484_ChIP-ChIP_HCT116_Human2.39757353
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.39542450
22EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.28769740
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.28733003
24RBPJ_22232070_ChIP-Seq_NCS_Mouse2.28077063
25* REST_18959480_ChIP-ChIP_MESCs_Mouse2.25136187
26SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.22185656
27RNF2_27304074_Chip-Seq_ESCs_Mouse2.13198742
28RNF2_27304074_Chip-Seq_NSC_Mouse2.08277497
29AR_21572438_ChIP-Seq_LNCaP_Human2.06635332
30* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.98010115
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.95002526
32EED_16625203_ChIP-ChIP_MESCs_Mouse1.90763428
33ERG_21242973_ChIP-ChIP_JURKAT_Human1.86754927
34TP53_20018659_ChIP-ChIP_R1E_Mouse1.86058217
35NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.84806032
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.83235125
37HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.80022779
38TAF15_26573619_Chip-Seq_HEK293_Human1.79191334
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.76790616
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.57939696
41DNAJC2_21179169_ChIP-ChIP_NT2_Human1.49016407
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.48714234
43PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.46781644
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.45991112
45EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.42305357
46SMAD4_21799915_ChIP-Seq_A2780_Human1.40690893
47* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.38899158
48KDM2B_26808549_Chip-Seq_K562_Human1.36348492
49WT1_25993318_ChIP-Seq_PODOCYTE_Human1.34426882
50P53_22127205_ChIP-Seq_FIBROBLAST_Human1.33058685
51TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.32268206
52CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.30355854
53PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30080362
54RING1B_27294783_Chip-Seq_ESCs_Mouse1.29936955
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28678782
56NR3C1_23031785_ChIP-Seq_PC12_Mouse1.27781225
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.27321492
58SOX2_21211035_ChIP-Seq_LN229_Gbm1.27145854
59* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.25729146
60* SMAD3_21741376_ChIP-Seq_EPCs_Human1.20479706
61ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.20256136
62STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.19949000
63* AR_19668381_ChIP-Seq_PC3_Human1.19300920
64STAT3_23295773_ChIP-Seq_U87_Human1.18321700
65ZFP281_18757296_ChIP-ChIP_E14_Mouse1.17978716
66GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17182074
67POU5F1_16153702_ChIP-ChIP_HESCs_Human1.14355727
68VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.12558854
69RING1B_27294783_Chip-Seq_NPCs_Mouse1.12305318
70WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.12214030
71* CTCF_27219007_Chip-Seq_Bcells_Human1.12030837
72ISL1_27105846_Chip-Seq_CPCs_Mouse1.06387470
73TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05466440
74POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05466440
75ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05057888
76TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04491639
77ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.04435195
78CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03715778
79THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.02802545
80P300_19829295_ChIP-Seq_ESCs_Human1.02050761
81TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01969422
82* SMAD3_21741376_ChIP-Seq_HESCs_Human1.00836495
83TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00640163
84PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.00041599
85TCF4_23295773_ChIP-Seq_U87_Human0.99862495
86VDR_22108803_ChIP-Seq_LS180_Human0.98966864
87ZFP57_27257070_Chip-Seq_ESCs_Mouse0.97800899
88SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95083759
89SMAD_19615063_ChIP-ChIP_OVARY_Human0.94781116
90AR_25329375_ChIP-Seq_VCAP_Human0.94345874
91KLF4_19829295_ChIP-Seq_ESCs_Human0.94144944
92ZFP281_27345836_Chip-Seq_ESCs_Mouse0.93538723
93PIAS1_25552417_ChIP-Seq_VCAP_Human0.92607788
94RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.92604951
95GATA1_26923725_Chip-Seq_HPCs_Mouse0.92285982
96* SMAD4_21741376_ChIP-Seq_HESCs_Human0.91703269
97* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91347839
98NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91032056
99CDX2_19796622_ChIP-Seq_MESCs_Mouse0.90584347
100* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.90562961
101* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.90544029
102TOP2B_26459242_ChIP-Seq_MCF-7_Human0.90531077
103KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.89679774
104TET1_21490601_ChIP-Seq_MESCs_Mouse0.89347340
105BMI1_23680149_ChIP-Seq_NPCS_Mouse0.89325169
106RUNX2_22187159_ChIP-Seq_PCA_Human0.89082194
107SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.88923620
108SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88841954
109PRDM14_20953172_ChIP-Seq_ESCs_Human0.88726228
110OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87946403
111AHR_22903824_ChIP-Seq_MCF-7_Human0.87871210
112DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.87404083
113RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.87296409
114WT1_19549856_ChIP-ChIP_CCG9911_Human0.86817788
115AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.86351475
116ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.86229068
117SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.86129951
118SMAD3_21741376_ChIP-Seq_ESCs_Human0.86114572
119ESR1_20079471_ChIP-ChIP_T-47D_Human0.86050059
120STAT3_18555785_ChIP-Seq_MESCs_Mouse0.83869817
121SMAD4_21741376_ChIP-Seq_EPCs_Human0.83786211
122ZNF274_21170338_ChIP-Seq_K562_Hela0.83022196
123TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.82269846
124SOX2_18555785_ChIP-Seq_MESCs_Mouse0.77560749
125POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.77028917
126LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.76361791
127CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.74616282
128NFIB_24661679_ChIP-Seq_LUNG_Mouse0.73290205
129FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.72198976
130PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.72143651
131* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.71067056
132MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.70768137

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0002822_catalepsy6.71714030
2MP0004859_abnormal_synaptic_plasticity6.21796415
3MP0003880_abnormal_central_pattern5.04731646
4* MP0003635_abnormal_synaptic_transmissio4.18267195
5* MP0009745_abnormal_behavioral_response3.71017625
6* MP0002063_abnormal_learning/memory/cond3.41624537
7MP0004270_analgesia3.19655717
8* MP0002064_seizures3.12619293
9MP0009046_muscle_twitch3.12360177
10MP0001984_abnormal_olfaction2.95080309
11MP0005423_abnormal_somatic_nervous2.89759365
12* MP0002572_abnormal_emotion/affect_behav2.82840441
13* MP0001486_abnormal_startle_reflex2.70005673
14* MP0002272_abnormal_nervous_system2.53271454
15MP0001968_abnormal_touch/_nociception2.41236178
16MP0001501_abnormal_sleep_pattern2.32805511
17* MP0001529_abnormal_vocalization2.31448589
18MP0003123_paternal_imprinting2.25382494
19MP0002734_abnormal_mechanical_nocicepti2.23403885
20MP0002653_abnormal_ependyma_morphology2.20176797
21* MP0005386_behavior/neurological_phenoty2.06739043
22* MP0004924_abnormal_behavior2.06739043
23MP0008789_abnormal_olfactory_epithelium2.05455108
24MP0000537_abnormal_urethra_morphology1.99210711
25MP0001970_abnormal_pain_threshold1.93532061
26MP0009053_abnormal_anal_canal1.91634166
27MP0002751_abnormal_autonomic_nervous1.89228861
28MP0002733_abnormal_thermal_nociception1.89061469
29* MP0002909_abnormal_adrenal_gland1.82119393
30* MP0001905_abnormal_dopamine_level1.81285535
31MP0008569_lethality_at_weaning1.80256824
32* MP0004811_abnormal_neuron_physiology1.75140303
33* MP0002557_abnormal_social/conspecific_i1.73846734
34MP0001440_abnormal_grooming_behavior1.65954551
35MP0008872_abnormal_physiological_respon1.65803661
36MP0002067_abnormal_sensory_capabilities1.65310736
37MP0003315_abnormal_perineum_morphology1.60710313
38MP0002090_abnormal_vision1.57667347
39MP0002184_abnormal_innervation1.54154660
40MP0002736_abnormal_nociception_after1.51321613
41MP0005187_abnormal_penis_morphology1.49094725
42MP0006276_abnormal_autonomic_nervous1.48479698
43MP0010030_abnormal_orbit_morphology1.46007602
44MP0002102_abnormal_ear_morphology1.45058050
45MP0000538_abnormal_urinary_bladder1.43722539
46MP0003879_abnormal_hair_cell1.40675923
47MP0003633_abnormal_nervous_system1.40546186
48MP0003121_genomic_imprinting1.39538622
49* MP0002066_abnormal_motor_capabilities/c1.38218656
50MP0001177_atelectasis1.34745416
51MP0003890_abnormal_embryonic-extraembry1.33667418
52* MP0003861_abnormal_nervous_system1.32429318
53MP0000955_abnormal_spinal_cord1.32415030
54MP0009780_abnormal_chondrocyte_physiolo1.31777584
55* MP0002882_abnormal_neuron_morphology1.27918743
56MP0005551_abnormal_eye_electrophysiolog1.25954789
57MP0002928_abnormal_bile_duct1.25720102
58MP0003075_altered_response_to1.25550275
59MP0002735_abnormal_chemical_nociception1.25430692
60MP0005377_hearing/vestibular/ear_phenot1.25060344
61MP0003878_abnormal_ear_physiology1.25060344
62MP0004885_abnormal_endolymph1.24596911
63MP0001502_abnormal_circadian_rhythm1.23304502
64MP0003119_abnormal_digestive_system1.21196417
65MP0000013_abnormal_adipose_tissue1.21011367
66* MP0008874_decreased_physiological_sensi1.20504920
67MP0005499_abnormal_olfactory_system1.19130173
68MP0005394_taste/olfaction_phenotype1.19130173
69MP0000566_synostosis1.18310420
70MP0003329_amyloid_beta_deposits1.17688766
71MP0003942_abnormal_urinary_system1.17567492
72MP0005670_abnormal_white_adipose1.12912021
73MP0003631_nervous_system_phenotype1.11742817
74MP0005167_abnormal_blood-brain_barrier1.11725949
75MP0004142_abnormal_muscle_tone1.11441230
76MP0000778_abnormal_nervous_system1.09721066
77MP0000569_abnormal_digit_pigmentation1.08462690
78MP0002163_abnormal_gland_morphology1.03242023
79* MP0005646_abnormal_pituitary_gland1.02946992
80MP0008961_abnormal_basal_metabolism1.02849019
81MP0003690_abnormal_glial_cell1.02820727
82MP0004858_abnormal_nervous_system1.01484662
83MP0006292_abnormal_olfactory_placode1.00312235
84MP0000751_myopathy1.00221039
85* MP0004085_abnormal_heartbeat0.99856276
86MP0002229_neurodegeneration0.99826034
87MP0001348_abnormal_lacrimal_gland0.99154840
88MP0003283_abnormal_digestive_organ0.98843980
89* MP0002069_abnormal_eating/drinking_beha0.95932832
90* MP0002152_abnormal_brain_morphology0.95604411
91MP0002160_abnormal_reproductive_system0.94590848
92* MP0005535_abnormal_body_temperature0.93632218
93MP0010234_abnormal_vibrissa_follicle0.92844718
94MP0000026_abnormal_inner_ear0.88516000
95MP0000516_abnormal_urinary_system0.88264662
96MP0005367_renal/urinary_system_phenotyp0.88264662
97MP0004133_heterotaxia0.86739999
98MP0003787_abnormal_imprinting0.86608013
99MP0000920_abnormal_myelination0.86192140
100MP0002697_abnormal_eye_size0.86083469
101MP0003011_delayed_dark_adaptation0.84193627
102MP0005645_abnormal_hypothalamus_physiol0.82694684
103MP0003385_abnormal_body_wall0.82478247
104MP0005248_abnormal_Harderian_gland0.82063732
105MP0003137_abnormal_impulse_conducting0.80496232
106MP0002233_abnormal_nose_morphology0.80129235
107MP0003634_abnormal_glial_cell0.79623557
108MP0010386_abnormal_urinary_bladder0.79266860
109MP0002081_perinatal_lethality0.79072486
110MP0005257_abnormal_intraocular_pressure0.77114066
111MP0006072_abnormal_retinal_apoptosis0.75533048
112MP0003937_abnormal_limbs/digits/tail_de0.75435158
113MP0000372_irregular_coat_pigmentation0.75277562
114MP0001286_abnormal_eye_development0.73580152
115* MP0001188_hyperpigmentation0.73391314
116MP0003122_maternal_imprinting0.73222346
117MP0002638_abnormal_pupillary_reflex0.73028850
118MP0003567_abnormal_fetal_cardiomyocyte0.70852167
119MP0003948_abnormal_gas_homeostasis0.70174323
120MP0005195_abnormal_posterior_eye0.69913366
121MP0002752_abnormal_somatic_nervous0.66593048
122MP0004742_abnormal_vestibular_system0.64797943
123MP0003632_abnormal_nervous_system0.64085864
124* MP0000631_abnormal_neuroendocrine_gland0.62104743
125MP0004215_abnormal_myocardial_fiber0.59841838
126MP0004233_abnormal_muscle_weight0.57667017
127MP0004043_abnormal_pH_regulation0.56010281
128MP0000534_abnormal_ureter_morphology0.55999422
129* MP0001943_abnormal_respiration0.52796640
130MP0001485_abnormal_pinna_reflex0.51406494
131* MP0003956_abnormal_body_size0.51033876
132MP0004036_abnormal_muscle_relaxation0.50900974
133MP0004145_abnormal_muscle_electrophysio0.48618463
134MP0001299_abnormal_eye_distance/0.48230705
135MP0005620_abnormal_muscle_contractility0.47735351
136MP0005166_decreased_susceptibility_to0.47036681
137MP0001963_abnormal_hearing_physiology0.46449976
138MP0000003_abnormal_adipose_tissue0.46327790
139MP0000747_muscle_weakness0.46212855
140* MP0010769_abnormal_survival0.45952465
141* MP0001664_abnormal_digestion0.45925492
142MP0005584_abnormal_enzyme/coenzyme_acti0.44895994
143* MP0010770_preweaning_lethality0.44757747

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)9.39905836
2Focal motor seizures (HP:0011153)7.02970947
3Limb dystonia (HP:0002451)5.65133068
4Focal seizures (HP:0007359)5.64599744
5Neonatal hypoglycemia (HP:0001998)4.72455434
6Visual hallucinations (HP:0002367)4.46156552
7Resting tremor (HP:0002322)4.34819970
8Action tremor (HP:0002345)4.10336069
9Ankle clonus (HP:0011448)4.08715183
10Hepatoblastoma (HP:0002884)4.01195573
11Poor eye contact (HP:0000817)3.73055860
12Annular pancreas (HP:0001734)3.70631138
13Abnormal pancreas size (HP:0012094)3.67462580
14Epileptic encephalopathy (HP:0200134)3.63156414
15Generalized tonic-clonic seizures (HP:0002069)3.60610921
16Febrile seizures (HP:0002373)3.57546815
17Absence seizures (HP:0002121)3.57423494
18* Torticollis (HP:0000473)3.56379303
19Impaired social interactions (HP:0000735)3.45194386
20Abnormal social behavior (HP:0012433)3.45194386
21Impaired vibration sensation in the lower limbs (HP:0002166)3.42401384
22Prolonged QT interval (HP:0001657)3.42191509
23* Anxiety (HP:0000739)3.34616144
24Progressive cerebellar ataxia (HP:0002073)3.33459762
25Dysdiadochokinesis (HP:0002075)3.32371889
26Broad-based gait (HP:0002136)3.31830453
27Urinary bladder sphincter dysfunction (HP:0002839)3.29120950
28Dialeptic seizures (HP:0011146)3.23683972
29Gaze-evoked nystagmus (HP:0000640)3.23514588
30Rib fusion (HP:0000902)3.15326231
31Limb hypertonia (HP:0002509)3.13460483
32Ankyloglossia (HP:0010296)3.10628027
33Postural instability (HP:0002172)3.10181584
34* Focal dystonia (HP:0004373)3.01526562
35* Depression (HP:0000716)2.99767465
36Abnormal EKG (HP:0003115)2.97851590
37* Craniofacial dystonia (HP:0012179)2.97202787
38Urinary urgency (HP:0000012)2.94928452
39Truncal ataxia (HP:0002078)2.93935935
40Supranuclear gaze palsy (HP:0000605)2.93250317
41Dysmetria (HP:0001310)2.91327706
42Atonic seizures (HP:0010819)2.86973931
43Papilledema (HP:0001085)2.86966650
44Stereotypic behavior (HP:0000733)2.83006471
45Dysmetric saccades (HP:0000641)2.80492445
46Scanning speech (HP:0002168)2.79555418
47Lower limb amyotrophy (HP:0007210)2.78994063
48Anomalous pulmonary venous return (HP:0010772)2.78508047
49Spastic gait (HP:0002064)2.76780494
50Abnormality of the intervertebral disk (HP:0005108)2.75728169
51Pointed chin (HP:0000307)2.74039940
52Bradykinesia (HP:0002067)2.73781028
53Fetal akinesia sequence (HP:0001989)2.72589396
54Pheochromocytoma (HP:0002666)2.66682880
55Atrioventricular block (HP:0001678)2.63595954
56Short 4th metacarpal (HP:0010044)2.61180394
57Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.61180394
58Hypothermia (HP:0002045)2.59947693
59Abnormal eating behavior (HP:0100738)2.59305822
60Oligodactyly (hands) (HP:0001180)2.58505550
61Mutism (HP:0002300)2.53635431
62Gait imbalance (HP:0002141)2.49208548
63Intention tremor (HP:0002080)2.47945714
64Impaired smooth pursuit (HP:0007772)2.46913370
65Drooling (HP:0002307)2.45925775
66Ventricular fibrillation (HP:0001663)2.45757760
67Agitation (HP:0000713)2.44817140
68Polygenic inheritance (HP:0010982)2.44014881
69Adrenal hypoplasia (HP:0000835)2.41522505
70Clonus (HP:0002169)2.41009077
71Anosmia (HP:0000458)2.38852561
72Progressive inability to walk (HP:0002505)2.37702081
73Abnormality of the pulmonary veins (HP:0011718)2.36836802
74Orthostatic hypotension (HP:0001278)2.34753314
75Megalencephaly (HP:0001355)2.34147491
76Self-mutilation (HP:0000742)2.33382938
77Central scotoma (HP:0000603)2.32831760
78Impaired vibratory sensation (HP:0002495)2.29760972
79Neuroendocrine neoplasm (HP:0100634)2.29494748
80Rigidity (HP:0002063)2.27617565
81Abnormality of ocular smooth pursuit (HP:0000617)2.27113614
82Abnormality of oral frenula (HP:0000190)2.25141353
83Lower limb muscle weakness (HP:0007340)2.24866232
84Amblyopia (HP:0000646)2.23746294
85Excessive salivation (HP:0003781)2.20172622
86Distal lower limb amyotrophy (HP:0008944)2.19266101
87Vaginal atresia (HP:0000148)2.19111003
88Cortical dysplasia (HP:0002539)2.16155358
89Heart block (HP:0012722)2.15587457
90Upper limb amyotrophy (HP:0009129)2.13342583
91Distal upper limb amyotrophy (HP:0007149)2.13342583
92Hypoplasia of the brainstem (HP:0002365)2.13093224
93Aplasia/Hypoplasia of the brainstem (HP:0007362)2.13093224
94Primary atrial arrhythmia (HP:0001692)2.11720177
95Neoplasm of the peripheral nervous system (HP:0100007)2.11685124
96Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.11638884
97Genetic anticipation (HP:0003743)2.11017545
98Anencephaly (HP:0002323)2.10340210
99Insidious onset (HP:0003587)2.08837030
100Termporal pattern (HP:0011008)2.08837030
101Renal hypoplasia (HP:0000089)2.08384922
102Abnormality of the 4th metacarpal (HP:0010012)2.07298405
103Genital tract atresia (HP:0001827)2.06479398
104Atrial fibrillation (HP:0005110)2.06095496
105Cerebral inclusion bodies (HP:0100314)2.05030058
106Abnormality of the corticospinal tract (HP:0002492)2.03849176
107Hemiparesis (HP:0001269)2.03634513
108EEG with generalized epileptiform discharges (HP:0011198)2.02329695
109Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.00541529
110Neurofibrillary tangles (HP:0002185)1.99525966
111Supraventricular tachycardia (HP:0004755)1.99425618
112Diastasis recti (HP:0001540)1.99421938
113Status epilepticus (HP:0002133)1.99356514
114Epileptiform EEG discharges (HP:0011182)1.98988994
115Neuronal loss in central nervous system (HP:0002529)1.98727382
116Polyphagia (HP:0002591)1.98209018
117Congenital primary aphakia (HP:0007707)1.97333577
118Hemiplegia (HP:0002301)1.97059346
119Abnormality of the lower motor neuron (HP:0002366)1.96308700
120Growth hormone deficiency (HP:0000824)1.95431749
121Congenital stationary night blindness (HP:0007642)1.95203379
122Poor suck (HP:0002033)1.94794538
123Labial hypoplasia (HP:0000066)1.93894744
124Aqueductal stenosis (HP:0002410)1.93647843
125Abnormal atrioventricular conduction (HP:0005150)1.93503276
126Nephrogenic diabetes insipidus (HP:0009806)1.93108734
127Dysphonia (HP:0001618)1.93022880
128Medial flaring of the eyebrow (HP:0010747)1.92803394
129Cutaneous finger syndactyly (HP:0010554)1.92674074
130Hyperventilation (HP:0002883)1.92566166
131Oligodactyly (HP:0012165)1.92553377
132Truncus arteriosus (HP:0001660)1.92360325
133Abnormality of the aortic arch (HP:0012303)1.91746383
134Supraventricular arrhythmia (HP:0005115)1.91679265
135Failure to thrive in infancy (HP:0001531)1.91580376
136Muscular hypotonia of the trunk (HP:0008936)1.89857294
137Abnormality of saccadic eye movements (HP:0000570)1.89169744
138Hypoventilation (HP:0002791)1.88603343
139Postural tremor (HP:0002174)1.87960761
140Neoplasm of the adrenal cortex (HP:0100641)1.87705591
141Morphological abnormality of the pyramidal tract (HP:0002062)1.87051388
142Hypsarrhythmia (HP:0002521)1.86937734
143Hemivertebrae (HP:0002937)1.85334276
144Bowel incontinence (HP:0002607)1.85286901
145* Incomplete penetrance (HP:0003829)1.83816337
146Bicornuate uterus (HP:0000813)1.83242507
147Retinal dysplasia (HP:0007973)1.82329263
148Overgrowth (HP:0001548)1.81850077
149Omphalocele (HP:0001539)1.81236670
150Amyotrophic lateral sclerosis (HP:0007354)1.80251241
151Arthropathy (HP:0003040)1.79560763
152High anterior hairline (HP:0009890)1.79108573
153Poor coordination (HP:0002370)1.78432816
154Alacrima (HP:0000522)1.77125153
155Optic nerve coloboma (HP:0000588)1.76087305
156Meningocele (HP:0002435)1.75367145
157Intestinal atresia (HP:0011100)1.74138111
158Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.73485793
159Congenital diaphragmatic hernia (HP:0000776)1.71272204
160Nephronophthisis (HP:0000090)1.70635284
161Bony spicule pigmentary retinopathy (HP:0007737)1.70026711
162Deep palmar crease (HP:0006191)1.69561127
163Cutaneous syndactyly (HP:0012725)1.69287661
164Specific learning disability (HP:0001328)1.69099663
165Hypoplastic female external genitalia (HP:0012815)1.68970160
166Down-sloping shoulders (HP:0200021)1.68686710
167Exotropia (HP:0000577)1.68203193
168Chorioretinal coloboma (HP:0000567)1.67246260
169Hypogonadotrophic hypogonadism (HP:0000044)1.66791592
170Molar tooth sign on MRI (HP:0002419)1.66531072
171Abnormality of midbrain morphology (HP:0002418)1.66531072
172Abnormality of the pubic bones (HP:0003172)1.65877343
173Chronic hepatic failure (HP:0100626)1.65652793
174Intellectual disability, moderate (HP:0002342)1.65195624
175Esophageal atresia (HP:0002032)1.64304406
176Recurrent corneal erosions (HP:0000495)1.64071551

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA47.47419866
2CASK4.66510265
3STK163.89165579
4NTRK33.79778906
5MAP3K93.41637855
6INSRR2.76270737
7KSR22.67561072
8DAPK22.56577435
9PRKD32.53167308
10DYRK22.40649597
11CAMKK12.32736465
12RIPK42.32658067
13NTRK12.22262369
14MAP3K42.21571945
15MINK12.20854569
16ICK2.20121287
17CAMK1D2.18718537
18FES1.97050705
19ARAF1.95751831
20NTRK21.88012654
21PAK61.82533462
22MARK11.75118749
23MAP3K131.73794927
24MATK1.72336227
25MAPK151.62022109
26TAOK11.57909516
27MAP2K71.54504231
28CAMKK21.52244167
29KSR11.48562529
30* CDK51.46441290
31EPHB21.46425274
32TNIK1.41009437
33TYRO31.38060396
34MAP3K21.37449252
35SIK21.33850074
36DAPK11.30021325
37MAP2K41.29393911
38DYRK1B1.28985259
39STK381.28858856
40PKN21.25151797
41DYRK31.21786812
42BCR1.21473804
43ERBB21.16326544
44MAP3K121.13248685
45PRPF4B1.10165807
46PINK11.08658162
47GRK51.06864608
48RAF11.05950318
49NEK11.05608205
50SGK2231.05054235
51SGK4941.05054235
52LATS21.04403695
53PRKCH1.01471927
54RIPK10.98395803
55RET0.97652240
56CDK150.94907337
57CDK180.93583134
58CDK140.90486870
59DDR20.90301571
60CAMK2B0.90095981
61CAMK2A0.89694366
62PRKCG0.89686864
63UHMK10.88203395
64PLK40.87499803
65MAP3K60.87452282
66STK110.87449752
67MAPKAPK50.87111450
68CSNK1A1L0.85987385
69BMPR20.84928220
70SGK20.83902510
71CDK11A0.83223639
72MARK20.81705072
73SGK30.80925157
74MAP3K10.77403478
75CSNK1G10.77247247
76CSNK1G20.76389067
77LMTK20.76226888
78TNK20.76141536
79WNK30.75819055
80CAMK10.74925249
81SGK10.74079814
82PHKG20.73704736
83PHKG10.73704736
84PDPK10.71982533
85PRKAA10.71294454
86PTK2B0.70517727
87PDK10.70289762
88CAMK2D0.69848862
89ALK0.69588210
90WNK10.68075359
91PKN10.65979005
92PNCK0.65936777
93MAP3K110.64934260
94CSNK1E0.62948904
95MAPK130.61263829
96PRKCZ0.59597373
97MAP2K10.59487329
98NME10.59262399
99CAMK2G0.57459678
100RPS6KA30.55948854
101FYN0.55546807
102MUSK0.55458768
103NEK60.54621083
104GRK10.54604215
105MAP3K70.53370309
106PRKD20.52090508
107PLK20.50901861
108MAPK100.50500803
109TRIB30.49346171
110DAPK30.47899794
111LIMK10.47290887
112PAK30.45325754
113BRSK10.42227388
114CAMK40.41980377
115MTOR0.41274088
116DYRK1A0.40957662
117PRKCB0.40522191
118MAPK80.38736696
119BRAF0.38057460
120MOS0.37761310
121CDC42BPA0.37094022
122CAMK1G0.36517715
123PRKD10.36257012
124CSNK1G30.35792178
125PRKCE0.35637417
126SCYL20.34064524
127FGFR20.33520732
128PRKG10.33382766
129PRKACA0.33370972
130CSNK1A10.32516612
131GSK3B0.31812945
132PRKACG0.31498688
133PTK20.31030398
134RPS6KA20.30370307
135WNK40.30370064
136PRKCA0.29546736
137PRKDC0.29342659
138STK390.29036386

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047404.14896300
2Synaptic vesicle cycle_Homo sapiens_hsa047213.12020458
3Morphine addiction_Homo sapiens_hsa050322.92823824
4Amphetamine addiction_Homo sapiens_hsa050312.91480743
5Nicotine addiction_Homo sapiens_hsa050332.85277883
6GABAergic synapse_Homo sapiens_hsa047272.84970997
7* Cocaine addiction_Homo sapiens_hsa050302.82385476
8Circadian entrainment_Homo sapiens_hsa047132.74040327
9* Dopaminergic synapse_Homo sapiens_hsa047282.51994884
10Glutamatergic synapse_Homo sapiens_hsa047242.42921678
11Cholinergic synapse_Homo sapiens_hsa047252.40395845
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.38875024
13Long-term potentiation_Homo sapiens_hsa047202.33734552
14Salivary secretion_Homo sapiens_hsa049702.04633510
15Renin secretion_Homo sapiens_hsa049241.99132109
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.92538366
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.89392410
18Insulin secretion_Homo sapiens_hsa049111.87135803
19Hedgehog signaling pathway_Homo sapiens_hsa043401.83298639
20Serotonergic synapse_Homo sapiens_hsa047261.81254728
21Oxidative phosphorylation_Homo sapiens_hsa001901.77113490
22Gastric acid secretion_Homo sapiens_hsa049711.73001087
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.70939737
24Oxytocin signaling pathway_Homo sapiens_hsa049211.68212280
25Calcium signaling pathway_Homo sapiens_hsa040201.64955299
26Notch signaling pathway_Homo sapiens_hsa043301.62199584
27Nitrogen metabolism_Homo sapiens_hsa009101.57591050
28Basal cell carcinoma_Homo sapiens_hsa052171.56542459
29GnRH signaling pathway_Homo sapiens_hsa049121.47769491
30Long-term depression_Homo sapiens_hsa047301.46289126
31* Gap junction_Homo sapiens_hsa045401.42960020
32Taste transduction_Homo sapiens_hsa047421.40601814
33Steroid biosynthesis_Homo sapiens_hsa001001.33252778
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.30170461
35Huntingtons disease_Homo sapiens_hsa050161.28682176
36* cAMP signaling pathway_Homo sapiens_hsa040241.26166589
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.22500594
38Phototransduction_Homo sapiens_hsa047441.20906742
39Alzheimers disease_Homo sapiens_hsa050101.20441899
40Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.15556773
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.15505429
42Hippo signaling pathway_Homo sapiens_hsa043901.11120496
43Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.08674461
44Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.05587433
45Vascular smooth muscle contraction_Homo sapiens_hsa042701.03527430
46Glioma_Homo sapiens_hsa052141.03206378
47Estrogen signaling pathway_Homo sapiens_hsa049151.02341237
48cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01701534
49Phosphatidylinositol signaling system_Homo sapiens_hsa040700.99712480
50* Alcoholism_Homo sapiens_hsa050340.99365463
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.99099621
52Type II diabetes mellitus_Homo sapiens_hsa049300.96780782
53Collecting duct acid secretion_Homo sapiens_hsa049660.95660712
54Cardiac muscle contraction_Homo sapiens_hsa042600.93928319
55Phospholipase D signaling pathway_Homo sapiens_hsa040720.92509711
56Wnt signaling pathway_Homo sapiens_hsa043100.90136122
57* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.87981874
58Melanogenesis_Homo sapiens_hsa049160.87597692
59Dilated cardiomyopathy_Homo sapiens_hsa054140.83696220
60Thyroid hormone synthesis_Homo sapiens_hsa049180.81998818
61ErbB signaling pathway_Homo sapiens_hsa040120.81846072
62Pancreatic secretion_Homo sapiens_hsa049720.80755577
63Dorso-ventral axis formation_Homo sapiens_hsa043200.79353331
64Oocyte meiosis_Homo sapiens_hsa041140.76726336
65Non-small cell lung cancer_Homo sapiens_hsa052230.75801942
66Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.73016963
67Axon guidance_Homo sapiens_hsa043600.68395261
68Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.68005373
69Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.66247105
70Vibrio cholerae infection_Homo sapiens_hsa051100.66194943
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65210275
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65141146
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64997147
74MAPK signaling pathway_Homo sapiens_hsa040100.61959896
75* Rap1 signaling pathway_Homo sapiens_hsa040150.61526823
76Choline metabolism in cancer_Homo sapiens_hsa052310.60875655
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60537893
78Bile secretion_Homo sapiens_hsa049760.58718950
79Maturity onset diabetes of the young_Homo sapiens_hsa049500.58650550
80Tight junction_Homo sapiens_hsa045300.57051929
81Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.56988004
82VEGF signaling pathway_Homo sapiens_hsa043700.56267476
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.54998349
84mTOR signaling pathway_Homo sapiens_hsa041500.54421440
85Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.53610659
86Type I diabetes mellitus_Homo sapiens_hsa049400.52923725
87Chemokine signaling pathway_Homo sapiens_hsa040620.52334339
88Circadian rhythm_Homo sapiens_hsa047100.49991360
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.49526868
90Tyrosine metabolism_Homo sapiens_hsa003500.48987077
91Glucagon signaling pathway_Homo sapiens_hsa049220.48734933
92Ras signaling pathway_Homo sapiens_hsa040140.47829966
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47292717
94Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.45174283
95Ribosome_Homo sapiens_hsa030100.44876895
96Ovarian steroidogenesis_Homo sapiens_hsa049130.44447071
97African trypanosomiasis_Homo sapiens_hsa051430.44244459
98Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.44184288
99Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43990452
100Endocytosis_Homo sapiens_hsa041440.43569586
101Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43132418
102Colorectal cancer_Homo sapiens_hsa052100.42060673
103Prolactin signaling pathway_Homo sapiens_hsa049170.41060435
104Parkinsons disease_Homo sapiens_hsa050120.40459273
105Prion diseases_Homo sapiens_hsa050200.39744177
106Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38070550
107Platelet activation_Homo sapiens_hsa046110.37670303
108Inositol phosphate metabolism_Homo sapiens_hsa005620.37491782
109Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36995544
110Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.36691959
111Renal cell carcinoma_Homo sapiens_hsa052110.36439300
112Endometrial cancer_Homo sapiens_hsa052130.35901542
113Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.35523179
114Pathways in cancer_Homo sapiens_hsa052000.35371574
115Glycerophospholipid metabolism_Homo sapiens_hsa005640.34524087
116Arginine biosynthesis_Homo sapiens_hsa002200.32971364
117Insulin signaling pathway_Homo sapiens_hsa049100.32104151
118Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31845704
119Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.31151472
120Thyroid cancer_Homo sapiens_hsa052160.30730199
121Fatty acid biosynthesis_Homo sapiens_hsa000610.30497149
122Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.30079856
123Butanoate metabolism_Homo sapiens_hsa006500.29419656
124Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.27606584
125Central carbon metabolism in cancer_Homo sapiens_hsa052300.24894944

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