DRD5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the D5 subtype of the dopamine receptor. The D5 subtype is a G-protein coupled receptor which stimulates adenylyl cyclase. This receptor is expressed in neurons in the limbic regions of the brain. It has a 10-fold higher affinity for dopamine than the D1 subtype. Pseudogenes related to this gene reside on chromosomes 1 and 2. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* regulation of female receptivity (GO:0045924)7.21138180
2ionotropic glutamate receptor signaling pathway (GO:0035235)6.35617323
3* female mating behavior (GO:0060180)6.33083838
4glutamate receptor signaling pathway (GO:0007215)5.83801615
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.24644779
6gamma-aminobutyric acid signaling pathway (GO:0007214)5.15676215
7vocalization behavior (GO:0071625)5.12036923
8protein localization to synapse (GO:0035418)5.01004393
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.95521671
10synaptic transmission, glutamatergic (GO:0035249)4.88871039
11regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)4.84801132
12primary amino compound metabolic process (GO:1901160)4.83569239
13synapsis (GO:0007129)4.82714846
14regulation of glutamate receptor signaling pathway (GO:1900449)4.82344430
15regulation of long-term neuronal synaptic plasticity (GO:0048169)4.78989925
16serotonin metabolic process (GO:0042428)4.77119428
17neuron recognition (GO:0008038)4.69015393
18neuron cell-cell adhesion (GO:0007158)4.64200437
19neuronal action potential propagation (GO:0019227)4.62227590
20fat-soluble vitamin catabolic process (GO:0042363)4.61366408
21vitamin catabolic process (GO:0009111)4.61366408
22synaptic vesicle exocytosis (GO:0016079)4.61340462
23regulation of short-term neuronal synaptic plasticity (GO:0048172)4.58687923
24regulation of DNA endoreduplication (GO:0032875)4.47718359
25sensory perception of taste (GO:0050909)4.39915464
26behavioral fear response (GO:0001662)4.39670315
27behavioral defense response (GO:0002209)4.39670315
28* neuron-neuron synaptic transmission (GO:0007270)4.38629448
29regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.38489658
30regulation of excitatory postsynaptic membrane potential (GO:0060079)4.36387482
31positive regulation of dendritic spine morphogenesis (GO:0061003)4.26182229
32response to histamine (GO:0034776)4.25817397
33axonal fasciculation (GO:0007413)4.25077061
34regulation of neuronal synaptic plasticity (GO:0048168)4.23391446
35detection of light stimulus involved in sensory perception (GO:0050962)4.23259311
36detection of light stimulus involved in visual perception (GO:0050908)4.23259311
37G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.17623070
38long-term synaptic potentiation (GO:0060291)4.16329846
39positive regulation of synapse maturation (GO:0090129)4.14981998
40chromosome organization involved in meiosis (GO:0070192)4.13279390
41regulation of dendritic spine morphogenesis (GO:0061001)4.12883855
42locomotory exploration behavior (GO:0035641)4.10366942
43fear response (GO:0042596)4.07488494
44inner ear receptor cell development (GO:0060119)4.07295359
45long-term memory (GO:0007616)4.05042009
46regulation of postsynaptic membrane potential (GO:0060078)4.04581879
47negative regulation of synaptic transmission, GABAergic (GO:0032229)4.03626063
48regulation of glutamate secretion (GO:0014048)4.02451109
49membrane depolarization during action potential (GO:0086010)4.01810659
50exploration behavior (GO:0035640)4.01789483
51membrane repolarization during action potential (GO:0086011)4.01610890
52neuronal action potential (GO:0019228)4.00575754
53glutamate secretion (GO:0014047)3.99842018
54synaptonemal complex assembly (GO:0007130)3.99111609
55positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.98372204
56* regulation of synaptic plasticity (GO:0048167)3.96870691
57male meiosis I (GO:0007141)3.93348463
58innervation (GO:0060384)3.86433746
59DNA methylation involved in gamete generation (GO:0043046)3.83216533
60regulation of neuron projection regeneration (GO:0070570)3.82597021
61regulation of axon regeneration (GO:0048679)3.82597021
62coenzyme catabolic process (GO:0009109)3.80362587
63cochlea development (GO:0090102)3.80158422
64gamma-aminobutyric acid transport (GO:0015812)3.77866264
65positive regulation of dendritic spine development (GO:0060999)3.73014797
66G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.72761907
67dendritic spine organization (GO:0097061)3.67057329
68* transmission of nerve impulse (GO:0019226)3.64310398
69synaptonemal complex organization (GO:0070193)3.63068085
70regulation of inositol phosphate biosynthetic process (GO:0010919)3.60866192
71cellular potassium ion homeostasis (GO:0030007)3.60726136
72negative regulation of appetite (GO:0032099)3.60338340
73negative regulation of response to food (GO:0032096)3.60338340
74synaptic vesicle endocytosis (GO:0048488)3.58448822
75regulation of dendritic spine development (GO:0060998)3.58102025
76regulation of synaptic vesicle exocytosis (GO:2000300)3.56125827
77indolalkylamine metabolic process (GO:0006586)3.55393511
78membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.49816091
79sensory perception of chemical stimulus (GO:0007606)3.49219814
80neurotransmitter-gated ion channel clustering (GO:0072578)3.48902192
81presynaptic membrane assembly (GO:0097105)3.43525287
82regulation of synaptic vesicle transport (GO:1902803)3.43502364
83regulation of vesicle fusion (GO:0031338)3.43169388
84negative regulation of T cell receptor signaling pathway (GO:0050860)3.41743991
85regulation of sensory perception of pain (GO:0051930)3.38621941
86regulation of sensory perception (GO:0051931)3.38621941
87positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.37341580
88piRNA metabolic process (GO:0034587)3.37161921
89kynurenine metabolic process (GO:0070189)3.36495501
90indole-containing compound metabolic process (GO:0042430)3.36095477
91positive regulation of membrane potential (GO:0045838)3.35179698
92dendritic spine morphogenesis (GO:0060997)3.33130116
93male meiosis (GO:0007140)3.30637712
94regulation of actin nucleation (GO:0051125)3.29676775
95regulation of synapse structural plasticity (GO:0051823)3.29203656
96membrane repolarization (GO:0086009)3.26294444
97presynaptic membrane organization (GO:0097090)3.26198309
98* learning (GO:0007612)3.26075696
99glycosphingolipid biosynthetic process (GO:0006688)3.23096633
100negative regulation of amino acid transport (GO:0051956)3.22933406
101cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.22477918
102meiosis I (GO:0007127)3.21490279
103positive regulation of neurotransmitter secretion (GO:0001956)3.20510917
104positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.20151939
105membrane depolarization (GO:0051899)3.20060893
106regulation of Rac GTPase activity (GO:0032314)3.18620490
107postsynaptic membrane organization (GO:0001941)3.18253078
108regulation of gonadotropin secretion (GO:0032276)3.18073212
109regulation of synapse maturation (GO:0090128)3.16895009
110chemosensory behavior (GO:0007635)3.16124709
111regulation of synaptic transmission, glutamatergic (GO:0051966)3.13233127
112sodium ion transmembrane transport (GO:0035725)3.12574613
113ephrin receptor signaling pathway (GO:0048013)3.12295519
114cerebellar Purkinje cell differentiation (GO:0021702)3.10489192
115calcium-mediated signaling using intracellular calcium source (GO:0035584)3.10479674
116startle response (GO:0001964)3.10098400
117behavioral response to cocaine (GO:0048148)3.09300338
118detection of calcium ion (GO:0005513)3.08108368
119meiotic nuclear division (GO:0007126)3.07670694
120membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.07044356
121synaptic vesicle maturation (GO:0016188)3.06636129
122serotonin receptor signaling pathway (GO:0007210)3.05927724
123cAMP-mediated signaling (GO:0019933)3.05234072
124neurotransmitter secretion (GO:0007269)3.03062532
125positive regulation of response to oxidative stress (GO:1902884)3.01301255
126positive regulation of cellular response to oxidative stress (GO:1900409)3.01301255
127* multicellular organismal signaling (GO:0035637)3.00856460
128relaxation of smooth muscle (GO:0044557)3.00393286
129protein-chromophore linkage (GO:0018298)3.00365947
130negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.00052569
131negative regulation of cell killing (GO:0031342)3.00052569
132negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.99180948
133neuron remodeling (GO:0016322)2.98024944
134cell communication by electrical coupling (GO:0010644)2.96877872
135regulation of heart rate by cardiac conduction (GO:0086091)2.96215921
136layer formation in cerebral cortex (GO:0021819)2.95929728
137* regulation of synaptic transmission (GO:0050804)2.95316578
138regulation of membrane repolarization (GO:0060306)2.93672703
139regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.93517615
140vesicle transport along microtubule (GO:0047496)2.93012655
141synaptic vesicle docking involved in exocytosis (GO:0016081)2.92834702
142positive regulation of fibroblast migration (GO:0010763)2.92652047
143* synaptic transmission (GO:0007268)2.92189499
144proline transport (GO:0015824)2.91699810
145behavioral response to nicotine (GO:0035095)2.90235566
146regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.89368565
147negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.88706949
148Rac protein signal transduction (GO:0016601)2.88620175
149neuronal ion channel clustering (GO:0045161)2.88464156
150potassium ion export (GO:0071435)2.84158551
151cardiac conduction (GO:0061337)2.83171642
152action potential (GO:0001508)2.79567546
153positive regulation of growth hormone secretion (GO:0060124)2.79241651
154regulation of response to food (GO:0032095)2.79009930
155potassium ion import (GO:0010107)2.78862910
156meiotic chromosome segregation (GO:0045132)2.77269961
157regulation of cholesterol esterification (GO:0010872)2.77125125
158cGMP metabolic process (GO:0046068)2.75965738
159* multicellular organismal reproductive behavior (GO:0033057)2.75068979
160reciprocal meiotic recombination (GO:0007131)2.74240384
161reciprocal DNA recombination (GO:0035825)2.74240384
162acid secretion (GO:0046717)2.72712636
163NIK/NF-kappaB signaling (GO:0038061)2.72641525
164negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.71857777
165regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.71122683
166regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.68715868
167adult walking behavior (GO:0007628)2.68204834
168potassium ion transmembrane transport (GO:0071805)2.68103453
169cellular potassium ion transport (GO:0071804)2.68103453
170regulation of hydrogen peroxide metabolic process (GO:0010310)2.65507425
171tryptophan catabolic process (GO:0006569)2.65119088
172indole-containing compound catabolic process (GO:0042436)2.65119088
173indolalkylamine catabolic process (GO:0046218)2.65119088
174otic vesicle formation (GO:0030916)2.64654329
175thyroid gland development (GO:0030878)2.62892308
176snRNA transcription (GO:0009301)2.61076084
177negative regulation of cytosolic calcium ion concentration (GO:0051481)2.61064777

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.77844585
2GBX2_23144817_ChIP-Seq_PC3_Human4.19054182
3* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.27608396
4* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.18569211
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.17330948
6* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.88305094
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.70743061
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.70743061
9SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.68696653
10* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.58987337
11EED_16625203_ChIP-ChIP_MESCs_Mouse2.52239041
12* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.48502989
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.47886464
14REST_21632747_ChIP-Seq_MESCs_Mouse2.44568399
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.43136281
16IKZF1_21737484_ChIP-ChIP_HCT116_Human2.38590125
17RARB_27405468_Chip-Seq_BRAIN_Mouse2.34802451
18* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.33430543
19CTBP1_25329375_ChIP-Seq_LNCAP_Human2.32837841
20RNF2_27304074_Chip-Seq_ESCs_Mouse2.11168363
21TAF15_26573619_Chip-Seq_HEK293_Human2.09816265
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.08013901
23CTBP2_25329375_ChIP-Seq_LNCAP_Human2.07722456
24SUZ12_27294783_Chip-Seq_ESCs_Mouse2.05653208
25P300_19829295_ChIP-Seq_ESCs_Human1.96002841
26SMAD4_21799915_ChIP-Seq_A2780_Human1.93475752
27FUS_26573619_Chip-Seq_HEK293_Human1.93239427
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.93123706
29CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.92075136
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.86481078
31* REST_18959480_ChIP-ChIP_MESCs_Mouse1.84540464
32VDR_22108803_ChIP-Seq_LS180_Human1.84063901
33AR_21572438_ChIP-Seq_LNCaP_Human1.78776507
34ZNF274_21170338_ChIP-Seq_K562_Hela1.77987223
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.75594258
36DROSHA_22980978_ChIP-Seq_HELA_Human1.75586369
37POU3F2_20337985_ChIP-ChIP_501MEL_Human1.75579251
38ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.75445761
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.72299687
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.70856867
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66303406
42TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.63099918
43* CTCF_27219007_Chip-Seq_Bcells_Human1.58589562
44* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.55901658
45PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.55659807
46* SMAD3_21741376_ChIP-Seq_EPCs_Human1.54612392
47BMI1_23680149_ChIP-Seq_NPCS_Mouse1.53807560
48RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.48245256
49* AR_25329375_ChIP-Seq_VCAP_Human1.47698722
50NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.47297929
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.47148480
52MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.46866805
53NR3C1_23031785_ChIP-Seq_PC12_Mouse1.46667411
54RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.46068140
55RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.45372415
56CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.44145462
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43497457
58UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.41276970
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.38658028
60* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38079364
61TP53_18474530_ChIP-ChIP_U2OS_Human1.37658255
62TP53_22573176_ChIP-Seq_HFKS_Human1.35387101
63TP53_16413492_ChIP-PET_HCT116_Human1.35257257
64ERG_21242973_ChIP-ChIP_JURKAT_Human1.34071055
65CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.32704549
66SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32291544
67* PRDM14_20953172_ChIP-Seq_ESCs_Human1.32200354
68BCAT_22108803_ChIP-Seq_LS180_Human1.30170962
69* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.26191494
70JUN_21703547_ChIP-Seq_K562_Human1.25784683
71STAT3_23295773_ChIP-Seq_U87_Human1.22010629
72RING1B_27294783_Chip-Seq_ESCs_Mouse1.21632600
73SOX2_21211035_ChIP-Seq_LN229_Gbm1.21009510
74THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.17029558
75NANOG_18555785_Chip-Seq_ESCs_Mouse1.13977992
76TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13572859
77* TCF4_23295773_ChIP-Seq_U87_Human1.12853062
78* RUNX2_22187159_ChIP-Seq_PCA_Human1.12819344
79ARNT_22903824_ChIP-Seq_MCF-7_Human1.12237184
80IGF1R_20145208_ChIP-Seq_DFB_Human1.11344416
81OCT4_20526341_ChIP-Seq_ESCs_Human1.10031290
82AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10023610
83CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09694440
84RAD21_21589869_ChIP-Seq_MESCs_Mouse1.09259892
85TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08491702
86POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08491702
87NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08409186
88FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.08327449
89SMAD_19615063_ChIP-ChIP_OVARY_Human1.07764890
90ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07532535
91* AR_19668381_ChIP-Seq_PC3_Human1.06463831
92CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.05375283
93PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05043982
94MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04723896
95* RING1B_27294783_Chip-Seq_NPCs_Mouse1.04246747
96NCOR_22424771_ChIP-Seq_293T_Human1.04139971
97KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03387449
98RNF2_27304074_Chip-Seq_NSC_Mouse1.03171823
99ERA_21632823_ChIP-Seq_H3396_Human1.02044302
100SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.01967630
101EWS_26573619_Chip-Seq_HEK293_Human1.01352412
102ER_23166858_ChIP-Seq_MCF-7_Human1.01323151
103TCF4_22108803_ChIP-Seq_LS180_Human1.00997655
104BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.99814721
105SMAD3_21741376_ChIP-Seq_HESCs_Human0.99809730
106GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.99447028
107EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.99309170
108EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98218375
109YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98031436
110P53_21459846_ChIP-Seq_SAOS-2_Human0.97271139
111CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.97243288
112AUTS2_25519132_ChIP-Seq_293T-REX_Human0.95156314
113LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.94712516
114E2F1_18555785_Chip-Seq_ESCs_Mouse0.94669260
115* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.94625377
116PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.94482304
117E2F1_20622854_ChIP-Seq_HELA_Human0.94297988
118SOX2_21211035_ChIP-Seq_LN229_Human0.94163925
119HOXB7_26014856_ChIP-Seq_BT474_Human0.93904942
120EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.93727526
121KDM2B_26808549_Chip-Seq_REH_Human0.93278644
122FOXA1_21572438_ChIP-Seq_LNCaP_Human0.93206106
123P53_22387025_ChIP-Seq_ESCs_Mouse0.92619921
124WT1_25993318_ChIP-Seq_PODOCYTE_Human0.92533001
125P53_22127205_ChIP-Seq_FIBROBLAST_Human0.92330776
126TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.91549973
127MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91154000
128* GATA3_21878914_ChIP-Seq_MCF-7_Human0.90855951
129WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.90091169
130PHF8_20622854_ChIP-Seq_HELA_Human0.88778776
131EGR1_19032775_ChIP-ChIP_M12_Human0.88012419
132* SMAD4_21741376_ChIP-Seq_EPCs_Human0.87274982
133* FOXH1_21741376_ChIP-Seq_EPCs_Human0.86584099
134SOX2_19829295_ChIP-Seq_ESCs_Human0.86402688
135NANOG_19829295_ChIP-Seq_ESCs_Human0.86402688
136P68_20966046_ChIP-Seq_HELA_Human0.86288087
137SA1_27219007_Chip-Seq_Bcells_Human0.84991680
138PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.84193172
139RAC3_21632823_ChIP-Seq_H3396_Human0.83767053
140ETV2_25802403_ChIP-Seq_MESCs_Mouse0.82724282
141SMAD3_21741376_ChIP-Seq_ESCs_Human0.82670842
142TP53_20018659_ChIP-ChIP_R1E_Mouse0.82656746
143SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82481627

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.88381930
2MP0003880_abnormal_central_pattern6.86361589
3MP0003635_abnormal_synaptic_transmissio4.28871819
4MP0009745_abnormal_behavioral_response3.67945436
5MP0002063_abnormal_learning/memory/cond3.64677111
6MP0001986_abnormal_taste_sensitivity3.62466734
7MP0008004_abnormal_stomach_pH3.46098442
8MP0004270_analgesia3.23691455
9MP0001968_abnormal_touch/_nociception3.22738792
10MP0002064_seizures3.15711263
11MP0002736_abnormal_nociception_after3.14503004
12MP0003136_yellow_coat_color3.04400621
13MP0002653_abnormal_ependyma_morphology2.97503797
14MP0001501_abnormal_sleep_pattern2.96638862
15MP0002572_abnormal_emotion/affect_behav2.96313184
16MP0001440_abnormal_grooming_behavior2.81622671
17MP0002272_abnormal_nervous_system2.75884706
18MP0002735_abnormal_chemical_nociception2.65278108
19MP0008877_abnormal_DNA_methylation2.48361417
20MP0001486_abnormal_startle_reflex2.23156787
21MP0003329_amyloid_beta_deposits2.21976968
22MP0009046_muscle_twitch2.07748028
23MP0002067_abnormal_sensory_capabilities1.98530268
24MP0000778_abnormal_nervous_system1.96779464
25MP0002132_abnormal_respiratory_system1.93618880
26MP0002837_dystrophic_cardiac_calcinosis1.93420884
27MP0002734_abnormal_mechanical_nocicepti1.93207973
28MP0001661_extended_life_span1.80316687
29MP0002733_abnormal_thermal_nociception1.79359854
30MP0002184_abnormal_innervation1.76166418
31MP0003119_abnormal_digestive_system1.74920756
32MP0003283_abnormal_digestive_organ1.71696612
33MP0001970_abnormal_pain_threshold1.67353161
34MP0009780_abnormal_chondrocyte_physiolo1.66801677
35MP0001529_abnormal_vocalization1.58392093
36MP0005423_abnormal_somatic_nervous1.52633061
37MP0002822_catalepsy1.52306287
38MP0002557_abnormal_social/conspecific_i1.46441774
39MP0001905_abnormal_dopamine_level1.46419410
40MP0004924_abnormal_behavior1.45018776
41MP0005386_behavior/neurological_phenoty1.45018776
42MP0002163_abnormal_gland_morphology1.40928353
43MP0003787_abnormal_imprinting1.39381128
44MP0003879_abnormal_hair_cell1.38219828
45* MP0006276_abnormal_autonomic_nervous1.38051217
46MP0002102_abnormal_ear_morphology1.35372552
47MP0006292_abnormal_olfactory_placode1.34505911
48MP0000955_abnormal_spinal_cord1.32253133
49MP0002066_abnormal_motor_capabilities/c1.32165022
50MP0004811_abnormal_neuron_physiology1.30904894
51MP0002882_abnormal_neuron_morphology1.29261944
52MP0004484_altered_response_of1.28266744
53MP0001188_hyperpigmentation1.25585821
54MP0001502_abnormal_circadian_rhythm1.24885606
55MP0002876_abnormal_thyroid_physiology1.24661616
56MP0004885_abnormal_endolymph1.23978211
57MP0003718_maternal_effect1.23904623
58MP0005646_abnormal_pituitary_gland1.23574634
59MP0004043_abnormal_pH_regulation1.23216184
60MP0005360_urolithiasis1.23146973
61MP0008569_lethality_at_weaning1.19566899
62MP0002160_abnormal_reproductive_system1.18340207
63MP0004858_abnormal_nervous_system1.16520946
64MP0003646_muscle_fatigue1.16371907
65MP0005409_darkened_coat_color1.16270163
66MP0000604_amyloidosis1.15813677
67MP0003633_abnormal_nervous_system1.12392371
68MP0004510_myositis1.11728377
69MP0010386_abnormal_urinary_bladder1.07775449
70MP0002210_abnormal_sex_determination1.07678989
71MP0004145_abnormal_muscle_electrophysio1.06534690
72MP0000751_myopathy1.05227915
73MP0001984_abnormal_olfaction1.02972577
74MP0008874_decreased_physiological_sensi1.01615882
75MP0002152_abnormal_brain_morphology1.01608365
76MP0009840_abnormal_foam_cell1.01595950
77MP0003631_nervous_system_phenotype0.98722083
78MP0004142_abnormal_muscle_tone0.98430620
79MP0000372_irregular_coat_pigmentation0.97424561
80MP0005645_abnormal_hypothalamus_physiol0.97161104
81MP0001963_abnormal_hearing_physiology0.95782656
82MP0009379_abnormal_foot_pigmentation0.95437694
83MP0004215_abnormal_myocardial_fiber0.94112908
84MP0004147_increased_porphyrin_level0.91976041
85MP0005551_abnormal_eye_electrophysiolog0.91888160
86MP0002229_neurodegeneration0.89148390
87MP0004130_abnormal_muscle_cell0.87659229
88MP0004085_abnormal_heartbeat0.85679492
89MP0001765_abnormal_ion_homeostasis0.85664367
90MP0002069_abnormal_eating/drinking_beha0.85610137
91MP0003938_abnormal_ear_development0.85343326
92MP0003698_abnormal_male_reproductive0.85147388
93MP0005535_abnormal_body_temperature0.84956373
94MP0000538_abnormal_urinary_bladder0.84164117
95MP0005171_absent_coat_pigmentation0.83610612
96MP0002234_abnormal_pharynx_morphology0.82324858
97MP0003638_abnormal_response/metabolism_0.81761333
98MP0003075_altered_response_to0.81117746
99MP0000678_abnormal_parathyroid_gland0.80601686
100MP0004742_abnormal_vestibular_system0.79273879
101MP0008872_abnormal_physiological_respon0.78520409
102MP0001177_atelectasis0.77562646
103MP0001664_abnormal_digestion0.76766556
104MP0000026_abnormal_inner_ear0.75226444
105MP0003122_maternal_imprinting0.74927553
106MP0010234_abnormal_vibrissa_follicle0.73499825
107MP0002752_abnormal_somatic_nervous0.73052860
108MP0005499_abnormal_olfactory_system0.71126015
109MP0005394_taste/olfaction_phenotype0.71126015
110MP0005595_abnormal_vascular_smooth0.70937585
111* MP0002909_abnormal_adrenal_gland0.69704696
112MP0003121_genomic_imprinting0.68784822
113MP0009697_abnormal_copulation0.68586547
114MP0003123_paternal_imprinting0.67669178
115MP0000653_abnormal_sex_gland0.67448994
116MP0001929_abnormal_gametogenesis0.67183842
117MP0001485_abnormal_pinna_reflex0.67086074
118MP0008789_abnormal_olfactory_epithelium0.64983504
119MP0009384_cardiac_valve_regurgitation0.63832764
120MP0002090_abnormal_vision0.63785428
121MP0003632_abnormal_nervous_system0.63673046
122MP0003137_abnormal_impulse_conducting0.62985287
123MP0000631_abnormal_neuroendocrine_gland0.62842378
124MP0001145_abnormal_male_reproductive0.62705765
125* MP0000230_abnormal_systemic_arterial0.62413375
126MP0003634_abnormal_glial_cell0.61843707
127MP0000639_abnormal_adrenal_gland0.61503785
128MP0005187_abnormal_penis_morphology0.60999141
129MP0005389_reproductive_system_phenotype0.60670437
130MP0010329_abnormal_lipoprotein_level0.60433992
131MP0004019_abnormal_vitamin_homeostasis0.59548851
132MP0003690_abnormal_glial_cell0.59020085
133MP0005623_abnormal_meninges_morphology0.56410693
134MP0006072_abnormal_retinal_apoptosis0.54123990
135MP0003861_abnormal_nervous_system0.51700711
136MP0005620_abnormal_muscle_contractility0.50709045
137MP0000920_abnormal_myelination0.50550922
138MP0005410_abnormal_fertilization0.50383516

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)9.64419031
2Focal seizures (HP:0007359)6.05501737
3Atonic seizures (HP:0010819)5.74025259
4Visual hallucinations (HP:0002367)5.71335556
5Absence seizures (HP:0002121)5.27726933
6Epileptic encephalopathy (HP:0200134)5.21217757
7Myokymia (HP:0002411)5.13531673
8Hyperventilation (HP:0002883)5.13364131
9Dialeptic seizures (HP:0011146)5.05550464
10Cerebral inclusion bodies (HP:0100314)5.00194480
11Febrile seizures (HP:0002373)4.97740521
12Generalized tonic-clonic seizures (HP:0002069)4.22611327
13Cerebral hypomyelination (HP:0006808)4.21769162
14Abnormality of cochlea (HP:0000375)4.07789936
15Severe visual impairment (HP:0001141)3.99218498
16Tinnitus (HP:0000360)3.97752272
17Amblyopia (HP:0000646)3.94768137
18Neurofibrillary tangles (HP:0002185)3.92868661
19Broad-based gait (HP:0002136)3.67637060
20Drooling (HP:0002307)3.54971291
21Excessive salivation (HP:0003781)3.54971291
22Supranuclear gaze palsy (HP:0000605)3.52340611
23Spontaneous abortion (HP:0005268)3.43255256
24Bony spicule pigmentary retinopathy (HP:0007737)3.40846477
25Progressive cerebellar ataxia (HP:0002073)3.39199532
26Gonadotropin excess (HP:0000837)3.37890999
27Decreased central vision (HP:0007663)3.37038421
28Delusions (HP:0000746)3.34441354
29Abnormality of the lower motor neuron (HP:0002366)3.33506746
30Dysmetria (HP:0001310)3.26976134
31Abolished electroretinogram (ERG) (HP:0000550)3.25037990
32Ventricular fibrillation (HP:0001663)3.21589358
33Decreased electroretinogram (ERG) amplitude (HP:0000654)3.13652742
34Congenital stationary night blindness (HP:0007642)3.09980625
35Tubular atrophy (HP:0000092)3.09155191
36Morphological abnormality of the inner ear (HP:0011390)3.08497549
37Testicular atrophy (HP:0000029)3.05581441
38Diplopia (HP:0000651)3.03778732
39Abnormality of binocular vision (HP:0011514)3.03778732
40Hemiparesis (HP:0001269)3.01600884
41Aplasia/Hypoplasia of the tibia (HP:0005772)2.99837009
42Epileptiform EEG discharges (HP:0011182)2.96068715
43Truncal ataxia (HP:0002078)2.94524432
44CNS hypomyelination (HP:0003429)2.91945415
45Protruding tongue (HP:0010808)2.90498619
46Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.89111795
47Metabolic alkalosis (HP:0200114)2.88867723
4811 pairs of ribs (HP:0000878)2.85995661
49Absent speech (HP:0001344)2.84856167
50Anxiety (HP:0000739)2.79007145
51Attenuation of retinal blood vessels (HP:0007843)2.72956700
52Concave nail (HP:0001598)2.72529769
53Dysdiadochokinesis (HP:0002075)2.71621658
54Scanning speech (HP:0002168)2.68967971
55Poor eye contact (HP:0000817)2.68879919
56Failure to thrive in infancy (HP:0001531)2.65120168
57True hermaphroditism (HP:0010459)2.57451538
58Congenital malformation of the right heart (HP:0011723)2.55859496
59Double outlet right ventricle (HP:0001719)2.55859496
60Hydroureter (HP:0000072)2.55539616
61Generalized myoclonic seizures (HP:0002123)2.55456239
62Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.51992901
63Abnormality of salivation (HP:0100755)2.51902950
64Progressive inability to walk (HP:0002505)2.51465136
65Status epilepticus (HP:0002133)2.49508098
66Impaired vibration sensation in the lower limbs (HP:0002166)2.44265857
67Thickened helices (HP:0000391)2.43645389
68Oligodactyly (hands) (HP:0001180)2.43495426
69Impaired smooth pursuit (HP:0007772)2.42484288
70EEG with generalized epileptiform discharges (HP:0011198)2.40204154
71Prominent supraorbital ridges (HP:0000336)2.39872683
72Gaze-evoked nystagmus (HP:0000640)2.39611887
73Inability to walk (HP:0002540)2.37027567
74Abnormal biliary tract physiology (HP:0012439)2.36473637
75Bile duct proliferation (HP:0001408)2.36473637
76Global brain atrophy (HP:0002283)2.35892887
77Abnormal social behavior (HP:0012433)2.34537712
78Impaired social interactions (HP:0000735)2.34537712
79Pigmentary retinal degeneration (HP:0001146)2.32049693
80Rapidly progressive (HP:0003678)2.30786106
81Action tremor (HP:0002345)2.29285414
82Acute necrotizing encephalopathy (HP:0006965)2.28090655
83Retinal dysplasia (HP:0007973)2.27736050
84Shoulder girdle muscle weakness (HP:0003547)2.25911513
85Depression (HP:0000716)2.24955396
86Mesangial abnormality (HP:0001966)2.23566786
87Short tibia (HP:0005736)2.23471579
88Psychosis (HP:0000709)2.16930980
89Horizontal nystagmus (HP:0000666)2.14518596
90Constricted visual fields (HP:0001133)2.13728051
91Dysautonomia (HP:0002459)2.11017030
92Stereotypic behavior (HP:0000733)2.10754426
93Palpebral edema (HP:0100540)2.10055804
94Fair hair (HP:0002286)2.09647108
95Amyotrophic lateral sclerosis (HP:0007354)2.09277953
96Widely spaced teeth (HP:0000687)2.08142496
97Congenital sensorineural hearing impairment (HP:0008527)2.07447968
98Pancreatic fibrosis (HP:0100732)2.07447896
99Sensory axonal neuropathy (HP:0003390)2.07388386
100Abnormal respiratory epithelium morphology (HP:0012253)2.07048154
101Abnormal respiratory motile cilium morphology (HP:0005938)2.07048154
102Papilledema (HP:0001085)2.07047390
103Hypoplasia of the radius (HP:0002984)2.06898616
104Goiter (HP:0000853)2.06413369
105Blue irides (HP:0000635)2.06354167
106Hypsarrhythmia (HP:0002521)2.05944737
107Follicular hyperkeratosis (HP:0007502)2.05108730
108Progressive macrocephaly (HP:0004481)2.05060599
109Abnormality of renin-angiotensin system (HP:0000847)2.05017397
110Confusion (HP:0001289)2.04263268
111Retinitis pigmentosa (HP:0000510)2.04239269
112Prolonged QT interval (HP:0001657)2.02775462
113Decreased circulating renin level (HP:0003351)2.02487542
114Conical tooth (HP:0000698)2.01850791
115Retinal atrophy (HP:0001105)1.99247003
116Fibular hypoplasia (HP:0003038)1.98626746
117Syncope (HP:0001279)1.95746764
118Absent eyebrow (HP:0002223)1.95594056
119Absent phalangeal crease (HP:0006109)1.95061568
120Abnormal mitochondria in muscle tissue (HP:0008316)1.92401119
121Dynein arm defect of respiratory motile cilia (HP:0012255)1.90755931
122Absent/shortened dynein arms (HP:0200106)1.90755931
123Rimmed vacuoles (HP:0003805)1.89718928
124Intention tremor (HP:0002080)1.89346898
125Bradykinesia (HP:0002067)1.88533007
126Spastic gait (HP:0002064)1.88013776
127Abnormality of ocular smooth pursuit (HP:0000617)1.87834573
128Unsteady gait (HP:0002317)1.86748851
129Heterochromia iridis (HP:0001100)1.86550027
130Clumsiness (HP:0002312)1.85751049
131Generalized hypopigmentation of hair (HP:0011358)1.84725326
132Delayed CNS myelination (HP:0002188)1.84137390
133Abnormal ciliary motility (HP:0012262)1.83466415
134Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.83063155
135Abnormality of alanine metabolism (HP:0010916)1.83063155
136Hyperalaninemia (HP:0003348)1.83063155
137Deep palmar crease (HP:0006191)1.82681333
138Abnormal eating behavior (HP:0100738)1.81966688
139Fetal akinesia sequence (HP:0001989)1.81436631
140Nephronophthisis (HP:0000090)1.80930597
141Abnormal rod and cone electroretinograms (HP:0008323)1.80799969
142Hypoplasia of the ulna (HP:0003022)1.80220420
143Gait imbalance (HP:0002141)1.78819261
144Exotropia (HP:0000577)1.78761392
145Incomplete penetrance (HP:0003829)1.77369197
146X-linked dominant inheritance (HP:0001423)1.77032105
147Mutism (HP:0002300)1.76818225
148Type II lissencephaly (HP:0007260)1.75527752
149Mitochondrial inheritance (HP:0001427)1.75235118
150Urinary bladder sphincter dysfunction (HP:0002839)1.75202974
151Aqueductal stenosis (HP:0002410)1.74021099
152Male pseudohermaphroditism (HP:0000037)1.73903970
153Pancreatic cysts (HP:0001737)1.73247705
154Gait ataxia (HP:0002066)1.72653137
155Choroideremia (HP:0001139)1.71597566
156Abnormality of the proximal phalanges of the hand (HP:0009834)1.70970378
157Postural instability (HP:0002172)1.70935597
158Genetic anticipation (HP:0003743)1.70772178
159Increased circulating renin level (HP:0000848)1.70232229
160Abnormality of the middle phalanges of the toes (HP:0010183)1.69779800
161Inappropriate behavior (HP:0000719)1.69180161
162Urinary urgency (HP:0000012)1.68895668
163Poor suck (HP:0002033)1.68603641
164Insidious onset (HP:0003587)1.68268901
165Termporal pattern (HP:0011008)1.68268901
166Ankle clonus (HP:0011448)1.67591269
167Lower limb asymmetry (HP:0100559)1.67566779
168Impaired pain sensation (HP:0007328)1.66912921
169Abnormality of pain sensation (HP:0010832)1.66912921
170Increased neuronal autofluorescent lipopigment (HP:0002074)1.65433199
171Abnormal finger flexion creases (HP:0006143)1.64723499
172Congenital primary aphakia (HP:0007707)1.61600037

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA46.41115856
2RIPK45.31531928
3FRK4.91205487
4NTRK34.85755006
5TEC2.70391738
6PDK22.65289945
7MAP3K92.63537149
8BMPR22.62310676
9MAP3K42.58364699
10ITK2.50876198
11MAP3K122.48923594
12PLK22.42151224
13MAP2K72.35813885
14MINK12.34882087
15PNCK2.29194603
16NME12.17320052
17PTK22.15605689
18CASK2.09041321
19PTK2B2.06112338
20MAP2K42.01627347
21TESK21.93028231
22FES1.89940781
23FGR1.83805654
24GRK51.81966101
25DAPK11.81028194
26KDR1.77347609
27MAP3K131.70742715
28ARAF1.67333196
29SIK21.64891705
30TNIK1.62144667
31CAMK2B1.59779569
32MAPKAPK51.56149927
33KSR21.54311507
34VRK21.53365594
35KSR11.51849024
36STK161.49752603
37GRK61.49722569
38CAMK2A1.47813160
39DAPK21.46348768
40NTRK11.46012215
41NUAK11.35143311
42MAP2K21.29136968
43PRKCG1.27552389
44CDK51.26337813
45GRK71.22893309
46MAP4K21.21815690
47GRK11.21808330
48ERBB21.21629646
49BUB11.18655915
50NTRK21.16760286
51CAMK1G1.16595129
52MARK11.13351768
53PINK11.10567951
54RAF11.09320623
55BMPR1B1.07311945
56BTK1.03637688
57MKNK10.99491935
58PAK60.96321948
59FER0.93922262
60LIMK10.93662688
61DYRK1A0.92451691
62TAF10.90613888
63PRPF4B0.87912588
64CDK120.87276504
65PRKCI0.86492739
66MAPK130.84268492
67CAMK2D0.83046535
68CSF1R0.81013467
69PRKD30.76920677
70MAP3K70.73251903
71MKNK20.73141390
72BMX0.68317137
73CDK190.66945023
74PIK3CA0.64619219
75PRKCE0.64265140
76CAMK10.64159156
77ROCK20.63707291
78SGK10.63029795
79DMPK0.62714270
80MAP3K20.61817072
81STK380.59939027
82TNK20.59777685
83MAPK40.59040007
84CDK140.58387986
85PRKCQ0.58092285
86CDK180.57755949
87CAMK2G0.56756484
88MAP3K60.56603371
89PRKAA20.56327210
90BRSK10.56204325
91CAMKK10.55641613
92MARK20.55584166
93DYRK20.53861268
94KIT0.53676143
95CDK150.53494969
96SIK30.53044844
97PLK10.52133966
98TYRO30.51663544
99SYK0.50476970
100BCR0.49448704
101LATS20.49414058
102PAK30.48840704
103ROCK10.47072522
104CDK11A0.46592463
105OXSR10.46232563
106ADRBK10.45907786
107FYN0.44322262
108MET0.44067613
109CSNK1G30.43655743
110CAMK1D0.43462500
111MOS0.43096083
112MAPK120.42911755
113MAP3K10.42049463
114UHMK10.40670795
115MUSK0.40453084
116CDK40.40338874
117LMTK20.39848620
118MAPK100.39764044
119PRKACA0.39751396
120NEK60.39562299
121DAPK30.39377131
122IKBKE0.38618256
123PDK10.37784271
124CAMK40.37470141
125BCKDK0.37439308
126IGF1R0.37073390
127BRAF0.36540590
128PRKCZ0.36513933
129STK110.36390114
130STK38L0.35885517
131PDPK10.35778760
132PRKCA0.34399756
133MAP2K10.32707610
134CSNK1E0.31219802
135RPS6KA30.30688576
136ADRBK20.26705918
137CSNK1G20.25236710
138PRKCB0.25177743
139ABL20.23248950
140STK390.22942736
141SGK2230.22928523
142SGK4940.22928523
143DDR20.22441217
144CDK30.22435996
145CAMKK20.21792053
146RET0.21717235
147PRKG10.20054384
148CSNK1A10.19668201

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.89411851
2Long-term potentiation_Homo sapiens_hsa047203.56182113
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.14969094
4Amphetamine addiction_Homo sapiens_hsa050312.90746450
5Glutamatergic synapse_Homo sapiens_hsa047242.86742146
6Circadian entrainment_Homo sapiens_hsa047132.85440281
7Tryptophan metabolism_Homo sapiens_hsa003802.63811582
8Morphine addiction_Homo sapiens_hsa050322.58436887
9GABAergic synapse_Homo sapiens_hsa047272.53400107
10Salivary secretion_Homo sapiens_hsa049702.45497821
11Taste transduction_Homo sapiens_hsa047422.30249525
12Synaptic vesicle cycle_Homo sapiens_hsa047212.24755889
13Olfactory transduction_Homo sapiens_hsa047402.23464143
14* Dopaminergic synapse_Homo sapiens_hsa047282.10361911
15Sulfur relay system_Homo sapiens_hsa041222.07737943
16Renin secretion_Homo sapiens_hsa049242.04721640
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.04673685
18Serotonergic synapse_Homo sapiens_hsa047261.92663466
19Long-term depression_Homo sapiens_hsa047301.91844188
20* Calcium signaling pathway_Homo sapiens_hsa040201.91210039
21Gastric acid secretion_Homo sapiens_hsa049711.85935165
22Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.85023428
23Arginine and proline metabolism_Homo sapiens_hsa003301.84238840
24Collecting duct acid secretion_Homo sapiens_hsa049661.83411961
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.77095154
26Oxytocin signaling pathway_Homo sapiens_hsa049211.76717937
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.73870565
28Histidine metabolism_Homo sapiens_hsa003401.71946792
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.69883037
30Insulin secretion_Homo sapiens_hsa049111.66086176
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.57057818
32Pentose and glucuronate interconversions_Homo sapiens_hsa000401.54564727
33Alzheimers disease_Homo sapiens_hsa050101.52959461
34Cholinergic synapse_Homo sapiens_hsa047251.52475868
35GnRH signaling pathway_Homo sapiens_hsa049121.49614316
36Retinol metabolism_Homo sapiens_hsa008301.48542383
37Oxidative phosphorylation_Homo sapiens_hsa001901.48058009
38Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.45198583
39beta-Alanine metabolism_Homo sapiens_hsa004101.43758188
40Ether lipid metabolism_Homo sapiens_hsa005651.40729171
41Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.37498902
42Homologous recombination_Homo sapiens_hsa034401.35522509
43Cardiac muscle contraction_Homo sapiens_hsa042601.32955565
44* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.30540638
45Sulfur metabolism_Homo sapiens_hsa009201.29728155
46Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.29440626
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.27752414
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.27009342
49* cAMP signaling pathway_Homo sapiens_hsa040241.25487018
50Chemical carcinogenesis_Homo sapiens_hsa052041.24942306
51Phosphatidylinositol signaling system_Homo sapiens_hsa040701.24037299
52Phototransduction_Homo sapiens_hsa047441.20356721
53Cocaine addiction_Homo sapiens_hsa050301.18831445
54Gap junction_Homo sapiens_hsa045401.17439666
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.16636742
56Axon guidance_Homo sapiens_hsa043601.16482244
57Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.15899715
58Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.15782999
59cGMP-PKG signaling pathway_Homo sapiens_hsa040221.12044599
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.11904874
61Glycerolipid metabolism_Homo sapiens_hsa005611.11489735
62Melanogenesis_Homo sapiens_hsa049161.09093479
63Non-homologous end-joining_Homo sapiens_hsa034501.07701870
64Fat digestion and absorption_Homo sapiens_hsa049751.05007749
65Vibrio cholerae infection_Homo sapiens_hsa051101.04286922
66Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.04246190
67Estrogen signaling pathway_Homo sapiens_hsa049151.03236459
68Vascular smooth muscle contraction_Homo sapiens_hsa042701.01773180
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.01471829
70Pancreatic secretion_Homo sapiens_hsa049721.01147795
71Glioma_Homo sapiens_hsa052141.00258935
72Vitamin digestion and absorption_Homo sapiens_hsa049770.96556154
73Linoleic acid metabolism_Homo sapiens_hsa005910.95893228
74Butanoate metabolism_Homo sapiens_hsa006500.95858877
75Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.93670910
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.92896227
77Choline metabolism in cancer_Homo sapiens_hsa052310.92752979
78African trypanosomiasis_Homo sapiens_hsa051430.91843215
79Lysine degradation_Homo sapiens_hsa003100.91667328
80Parkinsons disease_Homo sapiens_hsa050120.89730268
81Oocyte meiosis_Homo sapiens_hsa041140.86273246
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.85880639
83VEGF signaling pathway_Homo sapiens_hsa043700.85645583
84Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.85371434
85Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.85329699
86Arachidonic acid metabolism_Homo sapiens_hsa005900.84486887
87ABC transporters_Homo sapiens_hsa020100.84009212
88Fatty acid biosynthesis_Homo sapiens_hsa000610.83005848
89Primary bile acid biosynthesis_Homo sapiens_hsa001200.80690854
90Huntingtons disease_Homo sapiens_hsa050160.79169419
91Starch and sucrose metabolism_Homo sapiens_hsa005000.78953633
92Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71143799
93Thyroid hormone synthesis_Homo sapiens_hsa049180.70168713
94Fatty acid metabolism_Homo sapiens_hsa012120.69632267
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69357266
96Dorso-ventral axis formation_Homo sapiens_hsa043200.69071597
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67200750
98Propanoate metabolism_Homo sapiens_hsa006400.66868987
99Steroid biosynthesis_Homo sapiens_hsa001000.66573614
100Glucagon signaling pathway_Homo sapiens_hsa049220.66473685
101Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.65965538
102Phospholipase D signaling pathway_Homo sapiens_hsa040720.65957313
103Fatty acid degradation_Homo sapiens_hsa000710.64883941
104ErbB signaling pathway_Homo sapiens_hsa040120.63833951
105Type II diabetes mellitus_Homo sapiens_hsa049300.63448246
106Peroxisome_Homo sapiens_hsa041460.58856779
107Protein digestion and absorption_Homo sapiens_hsa049740.58422371
108Drug metabolism - other enzymes_Homo sapiens_hsa009830.57487093
109MAPK signaling pathway_Homo sapiens_hsa040100.54905639
110Dilated cardiomyopathy_Homo sapiens_hsa054140.54148689
111Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.52862578
112Rap1 signaling pathway_Homo sapiens_hsa040150.52644459
113Pyruvate metabolism_Homo sapiens_hsa006200.51914565
114Ras signaling pathway_Homo sapiens_hsa040140.49222476
115Metabolic pathways_Homo sapiens_hsa011000.48889213
116Inositol phosphate metabolism_Homo sapiens_hsa005620.48065862
117Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46047667
118Wnt signaling pathway_Homo sapiens_hsa043100.44694883
119SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44085395
120Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.41784783
121Prion diseases_Homo sapiens_hsa050200.41567703
122Cysteine and methionine metabolism_Homo sapiens_hsa002700.40734464
123RNA polymerase_Homo sapiens_hsa030200.40668788
124Mineral absorption_Homo sapiens_hsa049780.39653499
125Arginine biosynthesis_Homo sapiens_hsa002200.39499683
126Nitrogen metabolism_Homo sapiens_hsa009100.39048805
127PPAR signaling pathway_Homo sapiens_hsa033200.37100182
128Phenylalanine metabolism_Homo sapiens_hsa003600.36809001
129Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.36369402
130Proteasome_Homo sapiens_hsa030500.36130326
131Rheumatoid arthritis_Homo sapiens_hsa053230.36055332
132Circadian rhythm_Homo sapiens_hsa047100.34145784
133Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.34004818
134Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.32419150
135Sphingolipid signaling pathway_Homo sapiens_hsa040710.32146191
136Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.31048335
137Bile secretion_Homo sapiens_hsa049760.30811561
138Regulation of actin cytoskeleton_Homo sapiens_hsa048100.28041413
139Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.27913749
140Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.25795877
141Salmonella infection_Homo sapiens_hsa051320.24816290
142B cell receptor signaling pathway_Homo sapiens_hsa046620.23453310
143Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.23065103
144Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.22909349
145Neurotrophin signaling pathway_Homo sapiens_hsa047220.22529833
146Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.21953613
147Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.21914691
148Non-small cell lung cancer_Homo sapiens_hsa052230.21307914
149Alcoholism_Homo sapiens_hsa050340.20949847
150Shigellosis_Homo sapiens_hsa051310.16932905
151Ovarian steroidogenesis_Homo sapiens_hsa049130.15233611
152Thyroid hormone signaling pathway_Homo sapiens_hsa049190.14479606
153Tuberculosis_Homo sapiens_hsa051520.14114283
154Type I diabetes mellitus_Homo sapiens_hsa049400.12871173

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